SUB158 >= 3 any ring size 5 1.5792 PF01126 Heme oxygenase 0.5000 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.4806 PF08240 Alcohol dehydrogenase GroES-like domain 0.4624 PF00067 Cytochrome P450 0.4580 PF00106 short chain dehydrogenase 0.4081 PF00170 bZIP transcription factor 0.3939 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.3620 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.3509 PF08040 MNLL subunit 0.3395 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.3277 PF09166 Biliverdin reductase, catalytic 0.3223 PF00676 Dehydrogenase E1 component 0.3071 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.3046 PF03949 Malic enzyme, NAD binding domain 0.3038 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.3005 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.2870 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.2757 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.2739 PF10276 Zinc-finger domain 0.2503 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.2452 PF00390 Malic enzyme, N-terminal domain 0.2168 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.2124 PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 0.1899 PF06212 GRIM-19 protein 0.1654 PF04116 Fatty acid hydroxylase superfamily 0.1596 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.1574 PF03404 Mo-co oxidoreductase dimerisation domain 0.1530 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.1500 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.1491 PF05347 Complex 1 protein (LYR family), 0.1441 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0795 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0693 PF04716 ETC complex I subunit conserved region 0.0597 PF00171 Aldehyde dehydrogenase family 0.0416 PF00175 Oxidoreductase NAD-binding domain 0.0355 PF00384 Molybdopterin oxidoreductase 0.0327 PF02466 Tim17/Tim22/Tim23 family 0.0117 PF10531 SLBB domain 0.0050 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0024 PF00209 Sodium:neurotransmitter symporter family 0.0002 PF02779 Transketolase, pyrimidine binding domain SUB387 C(:C)(:C)(:N) 1.5630 PF00042 Globin 0.8648 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.3078 PF01387 Synuclein 0.2976 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.2282 PF00001 7 transmembrane receptor (rhodopsin family), 0.0485 PF00005 ABC transporter 0.0472 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0422 PF00962 Adenosine/AMP deaminase 0.0364 PF05347 Complex 1 protein (LYR family), 0.0356 PF00501 AMP-binding enzyme 0.0001 PF00061 Lipocalin / cytosolic fatty-acid binding protein family SUB840 CC1CC(C)CC1 1.3732 PF00191 Annexin 1.0170 PF01735 Lysophospholipase catalytic domain 0.4527 PF00105 Zinc finger, C4 type (two domains), 0.2031 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1684 PF02161 Progesterone receptor 0.1600 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0973 PF00001 7 transmembrane receptor (rhodopsin family), 0.0023 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase SUB414 S(~C)(~H) 1.2767 PF01124 MAPEG family 1.0204 PF00255 Glutathione peroxidase 0.8825 PF00462 Glutaredoxin 0.7500 PF01406 tRNA synthetases class I (C), catalytic domain 0.7094 PF00656 Caspase domain 0.6491 PF07686 Immunoglobulin V-set domain 0.5138 PF00149 Calcineurin-like phosphoesterase 0.5000 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.5000 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.5000 PF07722 Peptidase C26 0.4506 PF05995 Cysteine dioxygenase type I 0.4413 PF00806 Pumilio-family RNA binding repeat 0.4370 PF03002 Somatostatin/Cortistatin family 0.3120 PF00619 Caspase recruitment domain 0.3011 PF00778 DIX domain 0.2208 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.1286 PF05649 Peptidase family M13 0.1113 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0574 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0393 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0138 PF01431 Peptidase family M13 SUB32 >= 2 P 1.2402 PF00025 ADP-ribosylation factor family 1.1032 PF01370 NAD dependent epimerase/dehydratase family 1.0178 PF00334 Nucleoside diphosphate kinase 0.8892 PF00348 Polyprenyl synthetase 0.5000 PF00629 MAM domain 0.4698 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.4337 PF05347 Complex 1 protein (LYR family), 0.4151 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.3795 PF00153 Mitochondrial carrier protein 0.3527 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.3333 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.3161 PF00248 Aldo/keto reductase family 0.2896 PF00373 FERM central domain 0.2550 PF00378 Enoyl-CoA hydratase/isomerase family 0.2543 PF01363 FYVE zinc finger 0.2321 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.1594 PF08040 MNLL subunit 0.1391 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.1379 PF02770 Acyl-CoA dehydrogenase, middle domain 0.1364 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.1247 PF01064 Activin types I and II receptor domain 0.1192 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.1102 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.1043 PF10509 Galactokinase galactose-binding signature 0.0760 PF00074 Pancreatic ribonuclease 0.0749 PF00619 Caspase recruitment domain 0.0673 PF00288 GHMP kinases N terminal domain 0.0612 PF00071 Ras family 0.0603 PF08544 GHMP kinases C terminal 0.0600 PF01467 Cytidylyltransferase 0.0561 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0436 PF00069 Protein kinase domain 0.0184 PF00004 ATPase family associated with various cellular activities (AAA), 0.0111 PF00692 dUTPase 0.0076 PF01571 Aminomethyltransferase folate-binding domain 0.0013 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0002 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain SUB190 >= 2 unsaturated non-aromatic carbon-only ring size 6 1.0937 PF00020 TNFR/NGFR cysteine-rich region 0.7968 PF00071 Ras family 0.6183 PF00069 Protein kinase domain 0.6001 PF00432 Prenyltransferase and squalene oxidase repeat 0.5000 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.2959 PF00688 TGF-beta propeptide 0.0883 PF00362 Integrin, beta chain 0.0497 PF00001 7 transmembrane receptor (rhodopsin family), SUB410 O(:C)(:C) 1.0861 PF00001 7 transmembrane receptor (rhodopsin family), SUB670 Cl-C:C-C=O 1.0802 PF00069 Protein kinase domain 0.0963 PF00043 Glutathione S-transferase, C-terminal domain 0.0002 PF02798 Glutathione S-transferase, N-terminal domain SUB778 CC1CCC(O)CC1 1.0793 PF12497 Estrogen receptor beta 0.1021 PF00079 Serpin (serine protease inhibitor), 0.0151 PF00702 haloacid dehalogenase-like hydrolase SUB706 O=C-C-C-C-C(O)-C 1.0608 PF01391 Collagen triple helix repeat (20 copies), 0.8729 PF00079 Serpin (serine protease inhibitor), 0.7850 PF00229 TNF(Tumour Necrosis Factor), family 0.6786 PF03062 MBOAT family 0.4383 PF00104 Ligand-binding domain of nuclear hormone receptor 0.3275 PF00067 Cytochrome P450 0.2841 PF01347 Lipoprotein amino terminal region 0.2666 PF00071 Ras family 0.1760 PF02898 Nitric oxide synthase, oxygenase domain 0.1464 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.1437 PF00354 Pentaxin family 0.1116 PF00341 Platelet-derived growth factor (PDGF), 0.0759 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0163 PF00005 ABC transporter 0.0160 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like SUB503 N-C=C-[#1] 1.0525 PF00069 Protein kinase domain 0.4850 PF00067 Cytochrome P450 0.3671 PF07885 Ion channel 0.3214 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.1926 PF03098 Animal haem peroxidase 0.0754 PF03949 Malic enzyme, NAD binding domain 0.0597 PF00264 Common central domain of tyrosinase 0.0232 PF00390 Malic enzyme, N-terminal domain 0.0069 PF01007 Inward rectifier potassium channel SUB17 >= 4 N 1.0413 PF01916 Deoxyhypusine synthase 0.7597 PF00186 Dihydrofolate reductase 0.2958 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.2541 PF00067 Cytochrome P450 0.2485 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.1870 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.1401 PF00211 Adenylate and Guanylate cyclase catalytic domain 0.1109 PF00005 ABC transporter 0.1092 PF00175 Oxidoreductase NAD-binding domain 0.1056 PF01564 Spermine/spermidine synthase 0.0423 PF00206 Lyase 0.0324 PF00001 7 transmembrane receptor (rhodopsin family), SUB409 O(~H)(~S) 1.0341 PF00167 Fibroblast growth factor 0.5000 PF00188 Cysteine-rich secretory protein family 0.4615 PF00001 7 transmembrane receptor (rhodopsin family), 0.2378 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.2014 PF00578 AhpC/TSA family 0.1725 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0271 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0258 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0192 PF09193 Cholecystokinin A receptor, N-terminal 0.0008 PF02146 Sir2 family SUB656 O-C-C-C:C 1.0209 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.6377 PF00576 HIUase/Transthyretin family 0.2413 PF00001 7 transmembrane receptor (rhodopsin family), 0.1079 PF00027 Cyclic nucleotide-binding domain 0.1012 PF00625 Guanylate kinase SUB360 C(~C)(:N)(:N) 1.0113 PF05761 5" nucleotidase family 0.7061 PF00074 Pancreatic ribonuclease 0.5105 PF00017 SH2 domain 0.2422 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.2162 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.2085 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.2075 PF00156 Phosphoribosyl transferase domain 0.2066 PF00001 7 transmembrane receptor (rhodopsin family), 0.1904 PF00170 bZIP transcription factor 0.1696 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.1395 PF00106 short chain dehydrogenase 0.1007 PF08240 Alcohol dehydrogenase GroES-like domain 0.0935 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0877 PF01747 ATP-sulfurylase 0.0646 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0642 PF00300 Phosphoglycerate mutase family 0.0584 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0501 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0401 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0399 PF00041 Fibronectin type III domain 0.0318 PF12062 heparan sulfate-N-deacetylase 0.0087 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain SUB193 >= 3 any ring size 6 1.0006 PF09396 Thrombin light chain 0.4304 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.3724 PF04622 ERG2 and Sigma1 receptor like protein 0.2666 PF00017 SH2 domain 0.1826 PF00001 7 transmembrane receptor (rhodopsin family), 0.1249 PF00045 Hemopexin 0.1150 PF01471 Putative peptidoglycan binding domain 0.1029 PF00005 ABC transporter 0.0965 PF00018 SH3 domain SUB364 C(~F)(~F) 1.0005 PF00654 Voltage gated chloride channel 0.7152 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.5143 PF00146 NADH dehydrogenase 0.3530 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.1199 PF00173 Cytochrome b5-like Heme/Steroid binding domain SUB704 O-C-C-C-C-C(N)-C 0.9958 PF00214 Calcitonin / CGRP / IAPP family 0.4272 PF00040 Fibronectin type II domain 0.1692 PF00084 Sushi domain (SCR repeat), 0.1654 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.1267 PF00702 haloacid dehalogenase-like hydrolase 0.1244 PF00273 Serum albumin family 0.1053 PF00291 Pyridoxal-phosphate dependent enzyme 0.0939 PF00092 von Willebrand factor type A domain 0.0790 PF08742 C8 domain 0.0692 PF00094 von Willebrand factor type D domain 0.0528 PF00622 SPRY domain 0.0429 PF01869 BadF/BadG/BcrA/BcrD ATPase family SUB657 C-C-N-C-C 0.9904 PF07562 Nine Cysteines Domain of family 3 GPCR 0.2561 PF00822 PMP-22/EMP/MP20/Claudin family 0.1309 PF00084 Sushi domain (SCR repeat), 0.1160 PF00209 Sodium:neurotransmitter symporter family 0.1151 PF01007 Inward rectifier potassium channel 0.1012 PF01234 NNMT/PNMT/TEMT family 0.0841 PF00689 Cation transporting ATPase, C-terminus 0.0774 PF00194 Eukaryotic-type carbonic anhydrase 0.0609 PF00690 Cation transporter/ATPase, N-terminus 0.0249 PF00999 Sodium/hydrogen exchanger family 0.0199 PF00001 7 transmembrane receptor (rhodopsin family), 0.0161 PF00233 3"5"-cyclic nucleotide phosphodiesterase SUB38 >= 1 Cl 0.9790 PF08403 Amino acid permease N-terminal 0.4720 PF03630 Fumble 0.2012 PF00324 Amino acid permease 0.1066 PF03530 Calcium-activated SK potassium channel 0.0680 PF00689 Cation transporting ATPase, C-terminus 0.0423 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0048 PF00690 Cation transporter/ATPase, N-terminus 0.0013 PF03073 TspO/MBR family SUB498 O-C:C:N 0.9686 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.6007 PF00155 Aminotransferase class I and II 0.3709 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.3280 PF00266 Aminotransferase class-V 0.1739 PF00294 pfkB family carbohydrate kinase SUB537 O=C-C-N 0.9578 PF00375 Sodium:dicarboxylate symporter family 0.9255 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 0.6317 PF00579 tRNA synthetases class I (W and Y), 0.5787 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.5485 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.3835 PF00248 Aldo/keto reductase family 0.3238 PF01490 Transmembrane amino acid transporter protein 0.3074 PF00999 Sodium/hydrogen exchanger family 0.2879 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.2543 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.2538 PF00079 Serpin (serine protease inhibitor), 0.2400 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.2372 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.2125 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.2083 PF03034 Phosphatidyl serine synthase 0.1937 PF01841 Transglutaminase-like superfamily 0.1811 PF03074 Glutamate-cysteine ligase 0.1599 PF01266 FAD dependent oxidoreductase 0.1549 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.1468 PF02772 S-adenosylmethionine synthetase, central domain 0.1416 PF00102 Protein-tyrosine phosphatase 0.1358 PF01641 SelR domain 0.1352 PF00586 AIR synthase related protein, N-terminal domain 0.1305 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1274 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.1268 PF04775 Acyl-CoA thioester hydrolase/BAAT N-terminal region 0.1209 PF02769 AIR synthase related protein, C-terminal domain 0.1181 PF00155 Aminotransferase class I and II 0.1124 PF01471 Putative peptidoglycan binding domain 0.1093 PF08444 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region 0.1035 PF01597 Glycine cleavage H-protein 0.0743 PF00045 Hemopexin 0.0638 PF00291 Pyridoxal-phosphate dependent enzyme 0.0597 PF03483 B3/4 domain 0.0589 PF00458 WHEP-TRS domain 0.0577 PF00491 Arginase family 0.0549 PF00096 Zinc finger, C2H2 type 0.0489 PF02100 Ornithine decarboxylase antizyme 0.0460 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0445 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0394 PF03484 tRNA synthetase B5 domain 0.0228 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0228 PF00868 Transglutaminase family 0.0201 PF00343 Carbohydrate phosphorylase 0.0191 PF00856 SET domain 0.0183 PF01279 Parathyroid hormone family 0.0144 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0139 PF03199 Eukaryotic glutathione synthase 0.0088 PF05544 Proline racemase 0.0003 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase SUB253 >= 1 unsaturated non-aromatic carbon-only ring size 10 0.9464 PF00656 Caspase domain 0.3654 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.1797 PF02161 Progesterone receptor 0.1610 PF00191 Annexin 0.0850 PF00664 ABC transporter transmembrane region SUB369 C(~H)(~S) 0.9424 PF01770 Reduced folate carrier 0.3856 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.3538 PF00184 Neurohypophysial hormones, C-terminal Domain 0.2936 PF00248 Aldo/keto reductase family 0.2668 PF00084 Sushi domain (SCR repeat), 0.2443 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.2240 PF00576 HIUase/Transthyretin family 0.2240 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.2232 PF00079 Serpin (serine protease inhibitor), 0.2019 PF00756 Putative esterase 0.1710 PF06617 M-phase inducer phosphatase 0.1581 PF00581 Rhodanese-like domain 0.1478 PF00069 Protein kinase domain 0.1393 PF12497 Estrogen receptor beta 0.1358 PF00362 Integrin, beta chain 0.1310 PF00245 Alkaline phosphatase 0.1098 PF01471 Putative peptidoglycan binding domain 0.1005 PF00209 Sodium:neurotransmitter symporter family 0.0905 PF00045 Hemopexin 0.0187 PF07965 Integrin beta tail domain 0.0058 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0050 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0030 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0020 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0009 PF09334 tRNA synthetases class I (M), 0.0001 PF08725 Integrin beta cytoplasmic domain SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 0.9382 PF01429 Methyl-CpG binding domain 0.6021 PF00183 Hsp90 protein 0.5350 PF00106 short chain dehydrogenase 0.4673 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.3510 PF06907 Latexin 0.3253 PF00890 FAD binding domain 0.3092 PF03572 Peptidase family S41 0.2636 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1746 PF02525 Flavodoxin-like fold 0.1530 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0153 PF00128 Alpha amylase, catalytic domain 0.0131 PF02806 Alpha amylase, C-terminal all-beta domain SUB687 O=C-C-C-C-O 0.9277 PF03171 2OG-Fe(II), oxygenase superfamily 0.8365 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.6489 PF00939 Sodium:sulfate symporter transmembrane region 0.5051 PF01112 Asparaginase 0.5000 PF05328 CybS 0.2385 PF05193 Peptidase M16 inactive domain 0.2119 PF00274 Fructose-bisphosphate aldolase class-I 0.1916 PF01336 OB-fold nucleic acid binding domain 0.1873 PF00675 Insulinase (Peptidase family M16), 0.0931 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0897 PF04952 Succinylglutamate desuccinylase / Aspartoacylase family 0.0647 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0486 PF00571 CBS domain 0.0480 PF00105 Zinc finger, C4 type (two domains), 0.0342 PF00549 CoA-ligase 0.0018 PF00149 Calcineurin-like phosphoesterase SUB720 Oc1ccc(O)cc1 0.9235 PF00079 Serpin (serine protease inhibitor), 0.3841 PF00105 Zinc finger, C4 type (two domains), 0.0959 PF00501 AMP-binding enzyme 0.0473 PF01733 Nucleoside transporter SUB339 C(~C)(~C)(~H)(~N) 0.8717 PF00128 Alpha amylase, catalytic domain 0.4095 PF07690 Major Facilitator Superfamily 0.3729 PF07562 Nine Cysteines Domain of family 3 GPCR 0.3190 PF00155 Aminotransferase class I and II 0.3036 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.2840 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.2792 PF01409 tRNA synthetases class II core domain (F), 0.2773 PF01401 Angiotensin-converting enzyme 0.2694 PF00023 Ankyrin repeat 0.2661 PF03074 Glutamate-cysteine ligase 0.2357 PF00176 SNF2 family N-terminal domain 0.2248 PF00018 SH3 domain 0.2170 PF00667 FAD binding domain 0.2047 PF00152 tRNA synthetases class II (D, K and N), 0.1960 PF00375 Sodium:dicarboxylate symporter family 0.1936 PF00040 Fibronectin type II domain 0.1800 PF00133 tRNA synthetases class I (I, L, M and V), 0.1795 PF02574 Homocysteine S-methyltransferase 0.1754 PF02798 Glutathione S-transferase, N-terminal domain 0.1747 PF01039 Carboxyl transferase domain 0.1691 PF00324 Amino acid permease 0.1556 PF00258 Flavodoxin 0.1468 PF01641 SelR domain 0.1440 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.1435 PF06373 Cocaine and amphetamine regulated transcript protein (CART), 0.1345 PF01336 OB-fold nucleic acid binding domain 0.1207 PF00764 Arginosuccinate synthase 0.1205 PF00520 Ion transport protein 0.1043 PF00168 C2 domain 0.1023 PF00557 Metallopeptidase family M24 0.0896 PF00579 tRNA synthetases class I (W and Y), 0.0796 PF05649 Peptidase family M13 0.0747 PF04072 Leucine carboxyl methyltransferase 0.0617 PF04952 Succinylglutamate desuccinylase / Aspartoacylase family 0.0522 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0470 PF01431 Peptidase family M13 0.0408 PF02310 B12 binding domain 0.0254 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.0216 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 0.0152 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0126 PF00749 tRNA synthetases class I (E and Q), , catalytic domain 0.0091 PF03483 B3/4 domain 0.0070 PF00186 Dihydrofolate reductase 0.0056 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0052 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0007 PF00085 Thioredoxin SUB337 C(~C)(~C)(~C)(~N) 0.8707 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.4577 PF00431 CUB domain 0.3946 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.2080 PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain 0.1973 PF00243 Nerve growth factor family 0.1918 PF03308 ArgK protein 0.1461 PF01094 Receptor family ligand binding region 0.1293 PF09292 Endonuclease VIII-like 1, DNA bind 0.0959 PF00229 TNF(Tumour Necrosis Factor), family 0.0505 PF00273 Serum albumin family 0.0347 PF00001 7 transmembrane receptor (rhodopsin family), 0.0012 PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain SUB686 O=C-C-C-C-N 0.8648 PF02798 Glutathione S-transferase, N-terminal domain 0.5352 PF00060 Ligand-gated ion channel 0.5173 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.4655 PF00755 Choline/Carnitine o-acyltransferase 0.4543 PF01094 Receptor family ligand binding region 0.4507 PF00023 Ankyrin repeat 0.4139 PF01323 DSBA-like thioredoxin domain 0.3489 PF08763 Voltage gated calcium channel IQ domain 0.3486 PF04961 Formiminotransferase-cyclodeaminase 0.3129 PF00464 Serine hydroxymethyltransferase 0.2624 PF00068 Phospholipase A2 0.2485 PF07686 Immunoglobulin V-set domain 0.2467 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.2424 PF02971 Formiminotransferase domain 0.2142 PF00149 Calcineurin-like phosphoesterase 0.1972 PF07837 Formiminotransferase domain, N-terminal subdomain 0.1913 PF00255 Glutathione peroxidase 0.1772 PF00069 Protein kinase domain 0.1743 PF00413 Matrixin 0.1636 PF00310 Glutamine amidotransferases class-II 0.1582 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1576 PF00153 Mitochondrial carrier protein 0.1522 PF00493 MCM2/3/5 family 0.1490 PF00155 Aminotransferase class I and II 0.1451 PF07690 Major Facilitator Superfamily 0.1217 PF02934 GatB/GatE catalytic domain 0.0982 PF00375 Sodium:dicarboxylate symporter family 0.0778 PF02637 GatB domain 0.0730 PF00202 Aminotransferase class-III 0.0493 PF01124 MAPEG family 0.0478 PF02310 B12 binding domain 0.0039 PF00028 Cadherin domain SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 0.8538 PF01039 Carboxyl transferase domain 0.3275 PF00364 Biotin-requiring enzyme 0.2459 PF00643 B-box zinc finger 0.2253 PF00097 Zinc finger, C3HC4 type (RING finger), 0.1964 PF00918 Gastrin/cholecystokinin family 0.1878 PF04622 ERG2 and Sigma1 receptor like protein 0.1118 PF00001 7 transmembrane receptor (rhodopsin family), 0.0787 PF00341 Platelet-derived growth factor (PDGF), 0.0003 PF02785 Biotin carboxylase C-terminal domain 0.0002 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0002 PF01437 Plexin repeat 0.0001 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain SUB4 >= 32 H 0.8494 PF00625 Guanylate kinase 0.5095 PF08725 Integrin beta cytoplasmic domain 0.4740 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.3353 PF04051 Transport protein particle (TRAPP), component 0.2875 PF03765 CRAL/TRIO, N-terminus 0.2573 PF08441 Integrin alpha 0.2427 PF00068 Phospholipase A2 0.2007 PF00026 Eukaryotic aspartyl protease 0.2000 PF00357 Integrin alpha cytoplasmic region 0.1810 PF00650 CRAL/TRIO domain 0.1555 PF07965 Integrin beta tail domain 0.0997 PF00520 Ion transport protein 0.0913 PF00362 Integrin, beta chain 0.0831 PF01118 Semialdehyde dehydrogenase, NAD binding domain 0.0647 PF00273 Serum albumin family 0.0569 PF00102 Protein-tyrosine phosphatase 0.0543 PF00017 SH2 domain 0.0541 PF00653 Inhibitor of Apoptosis domain 0.0245 PF01007 Inward rectifier potassium channel SUB309 O-H 0.8485 PF00102 Protein-tyrosine phosphatase 0.6983 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.2810 PF00354 Pentaxin family 0.2780 PF06079 Apyrase 0.2097 PF00018 SH3 domain 0.1915 PF00106 short chain dehydrogenase 0.1467 PF00167 Fibroblast growth factor 0.1323 PF03098 Animal haem peroxidase 0.1322 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0923 PF03199 Eukaryotic glutathione synthase 0.0869 PF00474 Sodium:solute symporter family 0.0856 PF00850 Histone deacetylase domain 0.0853 PF00328 Histidine acid phosphatase 0.0234 PF01223 DNA/RNA non-specific endonuclease 0.0105 PF01033 Somatomedin B domain 0.0041 PF01471 Putative peptidoglycan binding domain 0.0041 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 0.0033 PF01063 Aminotransferase class IV 0.0007 PF07706 Aminotransferase ubiquitination site SUB567 O-C-C-N 0.8426 PF00464 Serine hydroxymethyltransferase 0.6385 PF00155 Aminotransferase class I and II 0.5500 PF00153 Mitochondrial carrier protein 0.5272 PF03489 Saposin-like type B, region 2 0.5070 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.4684 PF00557 Metallopeptidase family M24 0.4527 PF00266 Aminotransferase class-V 0.4342 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.3866 PF00248 Aldo/keto reductase family 0.3363 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.2904 PF04072 Leucine carboxyl methyltransferase 0.2312 PF00664 ABC transporter transmembrane region 0.2262 PF00764 Arginosuccinate synthase 0.1809 PF05995 Cysteine dioxygenase type I 0.1804 PF01409 tRNA synthetases class II core domain (F), 0.1647 PF01212 Beta-eliminating lyase 0.1252 PF01490 Transmembrane amino acid transporter protein 0.1230 PF00005 ABC transporter 0.1223 PF06021 Aralkyl acyl-CoA:amino acid N-acyltransferase 0.1217 PF03199 Eukaryotic glutathione synthase 0.1088 PF08444 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region 0.0983 PF02347 Glycine cleavage system P-protein 0.0973 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0959 PF00176 SNF2 family N-terminal domain 0.0921 PF00060 Ligand-gated ion channel 0.0832 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0642 PF01597 Glycine cleavage H-protein 0.0612 PF00458 WHEP-TRS domain 0.0513 PF00324 Amino acid permease 0.0482 PF03484 tRNA synthetase B5 domain 0.0443 PF00787 PX domain 0.0440 PF00079 Serpin (serine protease inhibitor), 0.0363 PF01336 OB-fold nucleic acid binding domain 0.0355 PF01641 SelR domain 0.0341 PF00375 Sodium:dicarboxylate symporter family 0.0301 PF03483 B3/4 domain 0.0262 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0183 PF00152 tRNA synthetases class II (D, K and N), 0.0182 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0156 PF00614 Phospholipase D Active site motif 0.0122 PF02574 Homocysteine S-methyltransferase 0.0088 PF02666 Phosphatidylserine decarboxylase 0.0072 PF00017 SH2 domain 0.0044 PF00795 Carbon-nitrogen hydrolase SUB5 >= 1 Li 0.8333 PF00459 Inositol monophosphatase family 0.5000 PF00514 Armadillo/beta-catenin-like repeat 0.2500 PF00069 Protein kinase domain SUB348 C(~C)(~H)(~O)(~O) 0.8333 PF00143 Interferon alpha/beta domain 0.6055 PF03414 Glycosyltransferase family 6 0.5410 PF00293 NUDIX domain 0.5000 PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), 0.4536 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 0.4132 PF04711 Apolipoprotein A-II (ApoA-II), 0.4085 PF07654 Immunoglobulin C1-set domain 0.3907 PF00337 Galactoside-binding lectin 0.2850 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.2338 PF08702 Fibrinogen alpha/beta chain family 0.2335 PF00200 Disintegrin 0.2250 PF01869 BadF/BadG/BcrA/BcrD ATPase family 0.2141 PF01562 Reprolysin family propeptide 0.2088 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.1727 PF07686 Immunoglobulin V-set domain 0.1464 PF00703 domain 0.0907 PF00041 Fibronectin type III domain 0.0905 PF00089 Trypsin 0.0697 PF00236 Glycoprotein hormone 0.0468 PF00079 Serpin (serine protease inhibitor), 0.0204 PF07645 Calcium-binding EGF domain SUB172 >= 5 any ring size 5 0.8284 PF07645 Calcium-binding EGF domain 0.5652 PF01122 Eukaryotic cobalamin-binding protein 0.2375 PF03308 ArgK protein 0.0328 PF01923 Cobalamin adenosyltransferase 0.0002 PF02310 B12 binding domain SUB680 C-C-C-C-C-C 0.8000 PF08718 Glycolipid transfer protein (GLTP), 0.4622 PF08534 Redoxin 0.3168 PF00089 Trypsin 0.1839 PF00337 Galactoside-binding lectin 0.1129 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0253 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0044 PF02932 Neurotransmitter-gated ion-channel transmembrane region SUB398 N(~C)(:C)(:C) 0.7906 PF02525 Flavodoxin-like fold 0.7182 PF00067 Cytochrome P450 0.6570 PF00071 Ras family 0.2096 PF10276 Zinc-finger domain 0.2015 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.1456 PF03308 ArgK protein 0.1161 PF00856 SET domain 0.0964 PF02493 MORN repeat 0.0953 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0864 PF10509 Galactokinase galactose-binding signature 0.0845 PF00501 AMP-binding enzyme 0.0736 PF08544 GHMP kinases C terminal 0.0700 PF00354 Pentaxin family 0.0470 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0318 PF01923 Cobalamin adenosyltransferase 0.0177 PF01770 Reduced folate carrier 0.0174 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0020 PF12605 Casein kinase 1 gamma C terminal SUB306 N-S 0.7896 PF00194 Eukaryotic-type carbonic anhydrase 0.6430 PF01007 Inward rectifier potassium channel 0.0118 PF07885 Ion channel 0.0061 PF00520 Ion transport protein SUB529 [#1]-N-C-[#1] 0.7886 PF00709 Adenylosuccinate synthetase 0.4431 PF00117 Glutamine amidotransferase class-I 0.3845 PF01490 Transmembrane amino acid transporter protein 0.3172 PF00155 Aminotransferase class I and II 0.3166 PF00112 Papain family cysteine protease 0.3016 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.2605 PF00989 PAS fold 0.2266 PF00586 AIR synthase related protein, N-terminal domain 0.2067 PF00206 Lyase 0.1962 PF00001 7 transmembrane receptor (rhodopsin family), 0.1908 PF01564 Spermine/spermidine synthase 0.1757 PF03372 Endonuclease/Exonuclease/phosphatase family 0.1429 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.1385 PF00051 Kringle domain 0.1268 PF04775 Acyl-CoA thioester hydrolase/BAAT N-terminal region 0.1133 PF00324 Amino acid permease 0.1113 PF01409 tRNA synthetases class II core domain (F), 0.1070 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.1036 PF00168 C2 domain 0.0865 PF01593 Flavin containing amine oxidoreductase 0.0841 PF00069 Protein kinase domain 0.0788 PF01597 Glycine cleavage H-protein 0.0611 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.0592 PF08444 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region 0.0541 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0507 PF06021 Aralkyl acyl-CoA:amino acid N-acyltransferase 0.0300 PF00005 ABC transporter 0.0284 PF00156 Phosphoribosyl transferase domain 0.0242 PF00145 C-5 cytosine-specific DNA methylase 0.0201 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0115 PF01842 ACT domain 0.0031 PF00214 Calcitonin / CGRP / IAPP family 0.0012 PF08441 Integrin alpha SUB681 O-C-C-C-C-C 0.7884 PF00023 Ankyrin repeat 0.3102 PF00501 AMP-binding enzyme 0.2572 PF00058 Low-density lipoprotein receptor repeat class B 0.2134 PF00107 Zinc-binding dehydrogenase 0.1622 PF00060 Ligand-gated ion channel 0.1397 PF00067 Cytochrome P450 0.0902 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0868 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0839 PF00324 Amino acid permease 0.0837 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0796 PF01094 Receptor family ligand binding region 0.0449 PF00487 Fatty acid desaturase 0.0385 PF00105 Zinc finger, C4 type (two domains), 0.0094 PF00413 Matrixin SUB664 O-C-C-O-[#1] 0.7878 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.5630 PF02065 Melibiase 0.5376 PF00328 Histidine acid phosphatase 0.5210 PF00265 Thymidine kinase 0.4370 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.3720 PF01370 NAD dependent epimerase/dehydratase family 0.3519 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.3156 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.3074 PF00043 Glutathione S-transferase, C-terminal domain 0.2873 PF01842 ACT domain 0.2859 PF03414 Glycosyltransferase family 6 0.2733 PF00405 Transferrin 0.2460 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 0.1901 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.1521 PF03360 Glycosyltransferase family 43 0.1441 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.1278 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.1074 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.1038 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.1026 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0727 PF01712 Deoxynucleoside kinase 0.0725 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0640 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0639 PF00535 Glycosyl transferase family 2 0.0599 PF03351 DOMON domain 0.0549 PF03949 Malic enzyme, NAD binding domain 0.0524 PF05790 Immunoglobulin C2-set domain 0.0438 PF00390 Malic enzyme, N-terminal domain 0.0359 PF01118 Semialdehyde dehydrogenase, NAD binding domain 0.0101 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0064 PF02806 Alpha amylase, C-terminal all-beta domain SUB695 O=C-C-C-C-C=O 0.7876 PF00551 Formyl transferase 0.7438 PF08240 Alcohol dehydrogenase GroES-like domain 0.6708 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.5824 PF04389 Peptidase family M28 0.5655 PF03951 Glutamine synthetase, beta-Grasp domain 0.5242 PF02059 Interleukin-3 0.5161 PF08763 Voltage gated calcium channel IQ domain 0.5000 PF01019 Gamma-glutamyltranspeptidase 0.4049 PF02934 GatB/GatE catalytic domain 0.3242 PF00795 Carbon-nitrogen hydrolase 0.3162 PF02127 Aminopeptidase I zinc metalloprotease (M18), 0.2898 PF00696 Amino acid kinase family 0.2890 PF00067 Cytochrome P450 0.2584 PF00749 tRNA synthetases class I (E and Q), , catalytic domain 0.2458 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.2406 PF00120 Glutamine synthetase, catalytic domain 0.2356 PF02769 AIR synthase related protein, C-terminal domain 0.2193 PF02793 Hormone receptor domain 0.1971 PF01590 GAF domain 0.1862 PF00255 Glutathione peroxidase 0.1821 PF07722 Peptidase C26 0.1674 PF00462 Glutaredoxin 0.1467 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.1418 PF00117 Glutamine amidotransferase class-I 0.1323 PF00246 Zinc carboxypeptidase 0.1144 PF00266 Aminotransferase class-V 0.1051 PF07654 Immunoglobulin C1-set domain 0.1012 PF00682 HMGL-like 0.0928 PF00756 Putative esterase 0.0816 PF00023 Ankyrin repeat 0.0767 PF02637 GatB domain 0.0758 PF03024 Folate receptor family 0.0233 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0222 PF01124 MAPEG family 0.0022 PF00310 Glutamine amidotransferases class-II 0.0002 PF00586 AIR synthase related protein, N-terminal domain SUB629 C-N-C-C:C 0.7846 PF00248 Aldo/keto reductase family 0.7083 PF00225 Kinesin motor domain 0.5139 PF02180 Bcl-2 homology region 4 0.4179 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.2355 PF01234 NNMT/PNMT/TEMT family 0.2187 PF00105 Zinc finger, C4 type (two domains), 0.2162 PF00001 7 transmembrane receptor (rhodopsin family), 0.1691 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1361 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.1090 PF00702 haloacid dehalogenase-like hydrolase 0.0685 PF00069 Protein kinase domain 0.0517 PF00005 ABC transporter 0.0230 PF08674 Acetylcholinesterase tetramerisation domain SUB424 N=O 0.7804 PF00211 Adenylate and Guanylate cyclase catalytic domain SUB703 O-C-C-C-C-C-N-C 0.7802 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.5518 PF02159 Oestrogen receptor 0.3827 PF01401 Angiotensin-converting enzyme 0.3384 PF08527 Protein-arginine deiminase (PAD), middle domain 0.3366 PF00211 Adenylate and Guanylate cyclase catalytic domain 0.2825 PF00069 Protein kinase domain 0.2621 PF02223 Thymidylate kinase 0.2019 PF01687 Riboflavin kinase 0.1950 PF00702 haloacid dehalogenase-like hydrolase 0.1940 PF01467 Cytidylyltransferase 0.1627 PF00175 Oxidoreductase NAD-binding domain 0.1609 PF00079 Serpin (serine protease inhibitor), 0.1396 PF08526 Protein-arginine deiminase (PAD), N-terminal domain 0.1333 PF03068 Protein-arginine deiminase (PAD), 0.1297 PF00643 B-box zinc finger 0.1101 PF00406 Adenylate kinase 0.1050 PF00255 Glutathione peroxidase 0.1050 PF00105 Zinc finger, C4 type (two domains), 0.0864 PF00017 SH2 domain 0.0741 PF02274 Amidinotransferase 0.0681 PF00214 Calcitonin / CGRP / IAPP family 0.0628 PF00571 CBS domain 0.0612 PF01323 DSBA-like thioredoxin domain 0.0414 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0252 PF00619 Caspase recruitment domain 0.0081 PF00071 Ras family 0.0013 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), SUB691 O-C-C-C-C-C-O 0.7753 PF02806 Alpha amylase, C-terminal all-beta domain 0.6225 PF01094 Receptor family ligand binding region 0.4624 PF00005 ABC transporter 0.4516 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.4005 PF01571 Aminomethyltransferase folate-binding domain 0.3547 PF01230 HIT domain 0.3252 PF00229 TNF(Tumour Necrosis Factor), family 0.3141 PF00551 Formyl transferase 0.3035 PF07654 Immunoglobulin C1-set domain 0.2988 PF01187 Macrophage migration inhibitory factor (MIF), 0.2879 PF00248 Aldo/keto reductase family 0.2844 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.2536 PF02310 B12 binding domain 0.2475 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.2461 PF03623 Focal adhesion targeting region 0.1976 PF02574 Homocysteine S-methyltransferase 0.1539 PF00349 Hexokinase 0.1514 PF04768 Protein of unknown function (DUF619), 0.1466 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.1222 PF02525 Flavodoxin-like fold 0.1127 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.1070 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.1053 PF01347 Lipoprotein amino terminal region 0.0998 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0951 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0695 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0553 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0517 PF00478 IMP dehydrogenase / GMP reductase domain SUB722 Oc1ccc(N)cc1 0.7736 PF00068 Phospholipase A2 0.2115 PF00656 Caspase domain 0.0756 PF06512 Sodium ion transport-associated SUB506 Cl-C:C-O 0.7734 PF00069 Protein kinase domain 0.0336 PF00001 7 transmembrane receptor (rhodopsin family), SUB330 C(~Br)(~H) 0.7574 PF00001 7 transmembrane receptor (rhodopsin family), 0.7500 PF01007 Inward rectifier potassium channel 0.5000 PF00631 GGL domain SUB208 >= 5 saturated or aromatic carbon-only ring size 6 0.7468 PF01160 Vertebrate endogenous opioids neuropeptide 0.5446 PF00089 Trypsin SUB336 C(~C)(~C)(~C)(~H) 0.7429 PF00133 tRNA synthetases class I (I, L, M and V), 0.5692 PF01007 Inward rectifier potassium channel 0.5235 PF01425 Amidase 0.4623 PF00005 ABC transporter 0.4135 PF01462 Leucine rich repeat N-terminal domain 0.2924 PF00051 Kringle domain 0.2748 PF00089 Trypsin 0.2392 PF04072 Leucine carboxyl methyltransferase 0.1873 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.1708 PF08763 Voltage gated calcium channel IQ domain 0.1171 PF00045 Hemopexin 0.1090 PF02166 Androgen receptor 0.1021 PF00341 Platelet-derived growth factor (PDGF), 0.0935 PF08441 Integrin alpha 0.0847 PF01471 Putative peptidoglycan binding domain 0.0813 PF01039 Carboxyl transferase domain 0.0671 PF04704 Zfx / Zfy transcription activation region 0.0514 PF05193 Peptidase M16 inactive domain 0.0369 PF00149 Calcineurin-like phosphoesterase 0.0330 PF00755 Choline/Carnitine o-acyltransferase 0.0309 PF00096 Zinc finger, C2H2 type 0.0308 PF08264 Anticodon-binding domain 0.0277 PF00675 Insulinase (Peptidase family M16), 0.0122 PF00194 Eukaryotic-type carbonic anhydrase 0.0119 PF01431 Peptidase family M13 0.0093 PF00520 Ion transport protein 0.0074 PF05649 Peptidase family M13 0.0068 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0065 PF01433 Peptidase family M1 0.0004 PF00690 Cation transporter/ATPase, N-terminus SUB389 C(:C)(:N)(:N) 0.7374 PF00106 short chain dehydrogenase 0.4229 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.3982 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.3277 PF00136 DNA polymerase family B 0.3069 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.2634 PF10531 SLBB domain 0.2395 PF02770 Acyl-CoA dehydrogenase, middle domain 0.2180 PF05347 Complex 1 protein (LYR family), 0.2125 PF02493 MORN repeat 0.2118 PF00899 ThiF family 0.1883 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.1581 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.1515 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.1217 PF00378 Enoyl-CoA hydratase/isomerase family 0.1130 PF12062 heparan sulfate-N-deacetylase 0.0962 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0937 PF04116 Fatty acid hydroxylase superfamily 0.0891 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0784 PF00300 Phosphoglycerate mutase family 0.0710 PF00248 Aldo/keto reductase family 0.0559 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0530 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0520 PF08544 GHMP kinases C terminal 0.0468 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0448 PF04716 ETC complex I subunit conserved region 0.0441 PF00316 Fructose-1-6-bisphosphatase 0.0438 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0379 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0285 PF10509 Galactokinase galactose-binding signature 0.0277 PF00288 GHMP kinases N terminal domain 0.0255 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0171 PF00501 AMP-binding enzyme 0.0093 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0047 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0024 PF00156 Phosphoribosyl transferase domain 0.0001 PF02817 e3 binding domain 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain SUB702 O-C-C-C-C-C(O)-C 0.7307 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.5374 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.4669 PF02055 O-Glycosyl hydrolase family 30 0.4598 PF01347 Lipoprotein amino terminal region 0.4479 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.2747 PF01391 Collagen triple helix repeat (20 copies), 0.2298 PF00762 Ferrochelatase 0.1246 PF00090 Thrombospondin type 1 domain 0.1182 PF00354 Pentaxin family 0.1054 PF03953 Tubulin C-terminal domain 0.0940 PF07645 Calcium-binding EGF domain 0.0899 PF00105 Zinc finger, C4 type (two domains), 0.0838 PF01055 Glycosyl hydrolases family 31 0.0784 PF00088 Trefoil (P-type), domain 0.0675 PF00236 Glycoprotein hormone 0.0414 PF00093 von Willebrand factor type C domain 0.0060 PF00560 Leucine Rich Repeat 0.0014 PF04711 Apolipoprotein A-II (ApoA-II), SUB449 C(-H)(=O) 0.7302 PF00107 Zinc-binding dehydrogenase 0.5000 PF03453 MoeA N-terminal region (domain I and II), 0.1290 PF00574 Clp protease 0.0739 PF00112 Papain family cysteine protease 0.0025 PF08246 Cathepsin propeptide inhibitor domain (I29), SUB252 >= 1 saturated or aromatic heteroatom-containing ring size 10 0.7300 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.5561 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.3115 PF01582 TIR domain 0.2248 PF01401 Angiotensin-converting enzyme 0.1756 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0380 PF00001 7 transmembrane receptor (rhodopsin family), SUB407 O(~C)(~H) 0.7294 PF00303 Thymidylate synthase 0.4571 PF00079 Serpin (serine protease inhibitor), 0.4283 PF00576 HIUase/Transthyretin family 0.4123 PF08240 Alcohol dehydrogenase GroES-like domain 0.3412 PF00169 PH domain 0.3132 PF01023 S-100/ICaBP type calcium binding domain 0.3116 PF00041 Fibronectin type III domain 0.2772 PF02898 Nitric oxide synthase, oxygenase domain 0.2476 PF00273 Serum albumin family 0.2399 PF00225 Kinesin motor domain 0.2319 PF00018 SH3 domain 0.2238 PF00929 Exonuclease 0.2060 PF06079 Apyrase 0.1949 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.1915 PF03949 Malic enzyme, NAD binding domain 0.1821 PF00202 Aminotransferase class-III 0.1667 PF01180 Dihydroorotate dehydrogenase 0.1468 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.1451 PF00106 short chain dehydrogenase 0.1446 PF01063 Aminotransferase class IV 0.1424 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.1412 PF02347 Glycine cleavage system P-protein 0.1348 PF01268 Formate--tetrahydrofolate ligase 0.1194 PF00343 Carbohydrate phosphorylase 0.0836 PF00474 Sodium:solute symporter family 0.0800 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0787 PF00175 Oxidoreductase NAD-binding domain 0.0598 PF00821 Phosphoenolpyruvate carboxykinase 0.0486 PF00248 Aldo/keto reductase family 0.0448 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0422 PF00560 Leucine Rich Repeat 0.0411 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0135 PF01212 Beta-eliminating lyase 0.0101 PF00557 Metallopeptidase family M24 SUB16 >= 2 N 0.7279 PF00194 Eukaryotic-type carbonic anhydrase 0.3077 PF02898 Nitric oxide synthase, oxygenase domain 0.2386 PF00324 Amino acid permease 0.2159 PF00171 Aldehyde dehydrogenase family 0.1935 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1715 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0866 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 0.0852 PF01033 Somatomedin B domain 0.0802 PF01223 DNA/RNA non-specific endonuclease 0.0630 PF00822 PMP-22/EMP/MP20/Claudin family 0.0476 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0460 PF00152 tRNA synthetases class II (D, K and N), 0.0156 PF00023 Ankyrin repeat 0.0063 PF01336 OB-fold nucleic acid binding domain SUB338 C(~C)(~C)(~C)(~O) 0.7260 PF00557 Metallopeptidase family M24 0.4642 PF00149 Calcineurin-like phosphoesterase 0.3285 PF00246 Zinc carboxypeptidase 0.3266 PF08384 Pro-opiomelanocortin, N-terminal region 0.2649 PF01733 Nucleoside transporter 0.2476 PF02161 Progesterone receptor 0.2287 PF00001 7 transmembrane receptor (rhodopsin family), 0.1705 PF02188 GoLoco motif 0.1584 PF02145 Rap/ran-GAP 0.0868 PF02898 Nitric oxide synthase, oxygenase domain 0.0617 PF00068 Phospholipase A2 0.0524 PF01477 PLAT/LH2 domain 0.0410 PF08035 Opioids neuropeptide 0.0083 PF00091 Tubulin/FtsZ family, GTPase domain SUB246 >= 1 unsaturated non-aromatic carbon-only ring size 9 0.7195 PF00071 Ras family SUB441 C(-C)(-O)(=O) 0.7149 PF00324 Amino acid permease 0.4804 PF01063 Aminotransferase class IV 0.4563 PF00092 von Willebrand factor type A domain 0.4203 PF00354 Pentaxin family 0.3983 PF00682 HMGL-like 0.3833 PF00151 Lipase 0.3778 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.3059 PF01433 Peptidase family M1 0.2829 PF00001 7 transmembrane receptor (rhodopsin family), 0.2700 PF06628 Catalase-related immune-responsive 0.2512 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.2298 PF00762 Ferrochelatase 0.2128 PF06021 Aralkyl acyl-CoA:amino acid N-acyltransferase 0.2122 PF01401 Angiotensin-converting enzyme 0.2077 PF02785 Biotin carboxylase C-terminal domain 0.1981 PF01699 Sodium/calcium exchanger protein 0.1953 PF01151 GNS1/SUR4 family 0.1951 PF07648 Kazal-type serine protease inhibitor domain 0.1748 PF01731 Arylesterase 0.1703 PF02970 Tubulin binding cofactor A 0.1604 PF08725 Integrin beta cytoplasmic domain 0.1590 PF01268 Formate--tetrahydrofolate ligase 0.1514 PF00689 Cation transporting ATPase, C-terminus 0.1437 PF00690 Cation transporter/ATPase, N-terminus 0.1240 PF03074 Glutamate-cysteine ligase 0.1194 PF00266 Aminotransferase class-V 0.1154 PF00571 CBS domain 0.1144 PF09127 Leukotriene A4 hydrolase, C-terminal 0.1142 PF02100 Ornithine decarboxylase antizyme 0.1079 PF00071 Ras family 0.0985 PF00122 E1-E2 ATPase 0.0916 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0900 PF03098 Animal haem peroxidase 0.0707 PF00105 Zinc finger, C4 type (two domains), 0.0654 PF00074 Pancreatic ribonuclease 0.0631 PF02807 ATP:guanido phosphotransferase, N-terminal domain 0.0537 PF08763 Voltage gated calcium channel IQ domain 0.0475 PF00084 Sushi domain (SCR repeat), 0.0464 PF11825 Protein of unknown function (DUF3345), 0.0430 PF00217 ATP:guanido phosphotransferase, C-terminal catalytic domain 0.0420 PF01023 S-100/ICaBP type calcium binding domain 0.0361 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0321 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0202 PF02772 S-adenosylmethionine synthetase, central domain 0.0144 PF01042 Endoribonuclease L-PSP 0.0079 PF01234 NNMT/PNMT/TEMT family SUB618 C-C-C-O-[#1] 0.7131 PF02155 Glucocorticoid receptor 0.6425 PF00310 Glutamine amidotransferases class-II 0.2820 PF00927 Transglutaminase family, C-terminal ig like domain 0.2560 PF00490 Delta-aminolevulinic acid dehydratase 0.2272 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.1771 PF00868 Transglutaminase family 0.1486 PF00884 Sulfatase 0.1432 PF00071 Ras family 0.1429 PF01841 Transglutaminase-like superfamily 0.0899 PF01532 Glycosyl hydrolase family 47 0.0894 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0760 PF00079 Serpin (serine protease inhibitor), 0.0731 PF00128 Alpha amylase, catalytic domain 0.0654 PF00224 Pyruvate kinase, barrel domain 0.0640 PF02574 Homocysteine S-methyltransferase 0.0617 PF01279 Parathyroid hormone family 0.0582 PF00571 CBS domain 0.0577 PF00764 Arginosuccinate synthase 0.0157 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0064 PF00487 Fatty acid desaturase 0.0046 PF00343 Carbohydrate phosphorylase 0.0043 PF07706 Aminotransferase ubiquitination site 0.0020 PF10420 Cytokine interleukin-12p40 C-terminus SUB694 O=C-C-C-C-C-O 0.7130 PF07654 Immunoglobulin C1-set domain 0.5884 PF07722 Peptidase C26 0.5513 PF00074 Pancreatic ribonuclease 0.5286 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.4566 PF00229 TNF(Tumour Necrosis Factor), family 0.4173 PF05378 Hydantoinase/oxoprolinase N-terminal region 0.3511 PF03024 Folate receptor family 0.3473 PF00696 Amino acid kinase family 0.3415 PF00749 tRNA synthetases class I (E and Q), , catalytic domain 0.3365 PF02798 Glutathione S-transferase, N-terminal domain 0.3356 PF01433 Peptidase family M1 0.3264 PF00795 Carbon-nitrogen hydrolase 0.2746 PF04768 Protein of unknown function (DUF619), 0.2660 PF07690 Major Facilitator Superfamily 0.2362 PF02127 Aminopeptidase I zinc metalloprotease (M18), 0.2175 PF00675 Insulinase (Peptidase family M16), 0.2119 PF00274 Fructose-bisphosphate aldolase class-I 0.1526 PF00255 Glutathione peroxidase 0.1417 PF00171 Aldehyde dehydrogenase family 0.1275 PF04389 Peptidase family M28 0.1241 PF05193 Peptidase M16 inactive domain 0.1154 PF00324 Amino acid permease 0.0991 PF01477 PLAT/LH2 domain 0.0659 PF00023 Ankyrin repeat 0.0459 PF00462 Glutaredoxin 0.0416 PF00060 Ligand-gated ion channel 0.0381 PF00005 ABC transporter 0.0239 PF02538 Hydantoinase B/oxoprolinase 0.0201 PF02637 GatB domain 0.0197 PF02934 GatB/GatE catalytic domain 0.0110 PF00155 Aminotransferase class I and II 0.0100 PF02219 Methylenetetrahydrofolate reductase 0.0081 PF00104 Ligand-binding domain of nuclear hormone receptor SUB133 >= 1 saturated or aromatic heteroatom-containing ring size 4 0.7125 PF00854 POT family 0.5000 PF12126 Protein of unknown function (DUF3583), 0.0386 PF00664 ABC transporter transmembrane region 0.0288 PF02460 Patched family SUB682 O-C-C-C-C-O 0.7104 PF01532 Glycosyl hydrolase family 47 0.5263 PF03360 Glycosyltransferase family 43 0.3789 PF00079 Serpin (serine protease inhibitor), 0.3056 PF00478 IMP dehydrogenase / GMP reductase domain 0.2643 PF00349 Hexokinase 0.2316 PF01259 SAICAR synthetase 0.2302 PF00171 Aldehyde dehydrogenase family 0.2209 PF00169 PH domain 0.2195 PF00175 Oxidoreductase NAD-binding domain 0.2016 PF05118 Aspartyl/Asparaginyl beta-hydroxylase 0.1974 PF00549 CoA-ligase 0.1725 PF00017 SH2 domain 0.1507 PF00343 Carbohydrate phosphorylase 0.1173 PF01144 Coenzyme A transferase 0.1090 PF00501 AMP-binding enzyme 0.0746 PF04952 Succinylglutamate desuccinylase / Aspartoacylase family 0.0461 PF03414 Glycosyltransferase family 6 0.0418 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0410 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0259 PF02910 domain 0.0192 PF00001 7 transmembrane receptor (rhodopsin family), SUB242 >= 1 any ring size 9 0.7051 PF01048 Phosphorylase superfamily 0.4282 PF00212 Atrial natriuretic peptide 0.2328 PF00478 IMP dehydrogenase / GMP reductase domain 0.2082 PF01590 GAF domain 0.1990 PF05649 Peptidase family M13 0.1694 PF00156 Phosphoribosyl transferase domain 0.1436 PF01431 Peptidase family M13 0.1168 PF00069 Protein kinase domain 0.0649 PF00067 Cytochrome P450 0.0125 PF00071 Ras family SUB515 O-N-C-C 0.7030 PF00305 Lipoxygenase 0.1529 PF01327 Polypeptide deformylase 0.1459 PF01471 Putative peptidoglycan binding domain 0.1446 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.1330 PF00045 Hemopexin 0.1004 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0642 PF01180 Dihydroorotate dehydrogenase SUB499 O-C=C-C 0.6964 PF00069 Protein kinase domain 0.2948 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.1959 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.1755 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0103 PF01477 PLAT/LH2 domain 0.0020 PF03098 Animal haem peroxidase 0.0001 PF00001 7 transmembrane receptor (rhodopsin family), SUB49 >= 4 I 0.6963 PF02423 Ornithine cyclodeaminase/mu-crystallin family SUB541 C-N-C-[#1] 0.6909 PF00755 Choline/Carnitine o-acyltransferase 0.0962 PF00005 ABC transporter 0.0658 PF00209 Sodium:neurotransmitter symporter family 0.0440 PF00474 Sodium:solute symporter family 0.0231 PF00194 Eukaryotic-type carbonic anhydrase 0.0066 PF00102 Protein-tyrosine phosphatase SUB433 C(-C)(-C)(=O) 0.6893 PF07884 Vitamin K epoxide reductase family 0.6389 PF00648 Calpain family cysteine protease 0.5817 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.5163 PF01067 Calpain large subunit, domain III 0.2698 PF00622 SPRY domain 0.2690 PF00089 Trypsin 0.2283 PF07690 Major Facilitator Superfamily 0.1329 PF02525 Flavodoxin-like fold 0.1092 PF00091 Tubulin/FtsZ family, GTPase domain 0.0882 PF03953 Tubulin C-terminal domain 0.0471 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0287 PF03098 Animal haem peroxidase 0.0257 PF08771 Rapamycin binding domain 0.0229 PF02259 FAT domain 0.0182 PF02260 FATC domain 0.0133 PF00273 Serum albumin family SUB448 C(-H)(=N) 0.6875 PF02267 ADP-ribosyl cyclase 0.0566 PF00105 Zinc finger, C4 type (two domains), 0.0476 PF08418 DNA polymerase alpha subunit B N-terminal 0.0188 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0061 PF08127 Peptidase family C1 propeptide SUB674 O=C-C=C-N 0.6793 PF00303 Thymidylate synthase 0.5852 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.5823 PF02219 Methylenetetrahydrofolate reductase 0.5201 PF01808 AICARFT/IMPCHase bienzyme 0.4342 PF02142 MGS-like domain 0.4323 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.3687 PF00550 Phosphopantetheine attachment site 0.3056 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.3031 PF00106 short chain dehydrogenase 0.1609 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.1515 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.1488 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.1044 PF00822 PMP-22/EMP/MP20/Claudin family 0.1043 PF00069 Protein kinase domain 0.1000 PF00105 Zinc finger, C4 type (two domains), 0.0897 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0751 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0571 PF00464 Serine hydroxymethyltransferase 0.0380 PF08063 PADR1 (NUC008), domain 0.0220 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0006 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0003 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain SUB288 C-F 0.6788 PF03477 ATP cone domain 0.3099 PF07686 Immunoglobulin V-set domain 0.2002 PF00520 Ion transport protein 0.1829 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1611 PF01094 Receptor family ligand binding region 0.1510 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1142 PF00248 Aldo/keto reductase family 0.0743 PF08996 DNA Polymerase alpha zinc finger 0.0567 PF01180 Dihydroorotate dehydrogenase 0.0543 PF00989 PAS fold 0.0538 PF02867 Ribonucleotide reductase, barrel domain 0.0232 PF03104 DNA polymerase family B, exonuclease domain SUB140 >= 2 saturated or aromatic heteroatom-containing ring size 4 0.6759 PF00069 Protein kinase domain 0.5000 PF02984 Cyclin, C-terminal domain 0.4928 PF00702 haloacid dehalogenase-like hydrolase 0.3885 PF00489 Interleukin-6/G-CSF/MGF family 0.0473 PF00122 E1-E2 ATPase 0.0287 PF00689 Cation transporting ATPase, C-terminus 0.0089 PF00690 Cation transporter/ATPase, N-terminus 0.0034 PF00005 ABC transporter 0.0009 PF00664 ABC transporter transmembrane region SUB194 >= 3 saturated or aromatic carbon-only ring size 6 0.6757 PF01180 Dihydroorotate dehydrogenase 0.2906 PF01094 Receptor family ligand binding region 0.2203 PF00493 MCM2/3/5 family 0.1998 PF00106 short chain dehydrogenase 0.1718 PF00702 haloacid dehalogenase-like hydrolase 0.1374 PF00069 Protein kinase domain 0.1068 PF00520 Ion transport protein 0.0922 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0804 PF00341 Platelet-derived growth factor (PDGF), 0.0664 PF00204 DNA gyrase B 0.0460 PF00005 ABC transporter 0.0056 PF05790 Immunoglobulin C2-set domain 0.0039 PF08070 DTHCT (NUC029), region SUB622 N-C:C:C:N 0.6742 PF00175 Oxidoreductase NAD-binding domain 0.5828 PF08240 Alcohol dehydrogenase GroES-like domain 0.5339 PF06628 Catalase-related immune-responsive 0.2395 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.1486 PF00023 Ankyrin repeat 0.1021 PF00005 ABC transporter 0.0981 PF00106 short chain dehydrogenase 0.0911 PF00107 Zinc-binding dehydrogenase 0.0907 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0892 PF00017 SH2 domain 0.0798 PF01017 STAT protein, all-alpha domain 0.0683 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0590 PF12062 heparan sulfate-N-deacetylase 0.0468 PF02817 e3 binding domain 0.0379 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0358 PF00300 Phosphoglycerate mutase family 0.0185 PF01582 TIR domain 0.0040 PF01591 6-phosphofructo-2-kinase 0.0007 PF02865 STAT protein, protein interaction domain 0.0001 PF02864 STAT protein, DNA binding domain SUB42 >= 1 K 0.6738 PF00324 Amino acid permease SUB216 >= 1 saturated or aromatic nitrogen-containing ring size 7 0.6701 PF00069 Protein kinase domain 0.2464 PF00169 PH domain 0.2117 PF00149 Calcineurin-like phosphoesterase SUB519 O=C-N-N 0.6700 PF00209 Sodium:neurotransmitter symporter family 0.2852 PF00664 ABC transporter transmembrane region SUB613 N-C-O-C-C 0.6653 PF02223 Thymidylate kinase 0.5000 PF00012 Hsp70 protein 0.3317 PF01712 Deoxynucleoside kinase 0.2057 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.1875 PF02267 ADP-ribosyl cyclase 0.1754 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 0.1561 PF10391 Fingers domain of DNA polymerase lambda 0.1140 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.1107 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0717 PF00211 Adenylate and Guanylate cyclase catalytic domain 0.0695 PF00001 7 transmembrane receptor (rhodopsin family), 0.0627 PF00316 Fructose-1-6-bisphosphatase 0.0378 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0356 PF00400 WD domain, G-beta repeat 0.0339 PF01467 Cytidylyltransferase 0.0006 PF00300 Phosphoglycerate mutase family 0.0001 PF02771 Acyl-CoA dehydrogenase, N-terminal domain SUB536 O=C-C-C 0.6620 PF07690 Major Facilitator Superfamily 0.6268 PF00264 Common central domain of tyrosinase 0.2383 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.1999 PF00071 Ras family 0.1667 PF00202 Aminotransferase class-III 0.1281 PF02780 Transketolase, C-terminal domain 0.1245 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.1185 PF00364 Biotin-requiring enzyme 0.0529 PF02779 Transketolase, pyrimidine binding domain 0.0462 PF00175 Oxidoreductase NAD-binding domain 0.0460 PF00291 Pyridoxal-phosphate dependent enzyme 0.0281 PF00001 7 transmembrane receptor (rhodopsin family), 0.0274 PF01590 GAF domain 0.0202 PF00520 Ion transport protein 0.0006 PF07706 Aminotransferase ubiquitination site SUB640 O-C-C-C-O 0.6548 PF00343 Carbohydrate phosphorylase 0.6441 PF00341 Platelet-derived growth factor (PDGF), 0.3537 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.3495 PF01230 HIT domain 0.2896 PF00069 Protein kinase domain 0.2415 PF00305 Lipoxygenase 0.2255 PF00084 Sushi domain (SCR repeat), 0.2152 PF03781 Formylglycine-generating sulfatase enzyme 0.1716 PF02055 O-Glycosyl hydrolase family 30 0.1647 PF01712 Deoxynucleoside kinase 0.1394 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1314 PF00079 Serpin (serine protease inhibitor), 0.1261 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0980 PF07654 Immunoglobulin C1-set domain 0.0946 PF00390 Malic enzyme, N-terminal domain 0.0728 PF00714 Interferon gamma 0.0690 PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain 0.0587 PF01536 Adenosylmethionine decarboxylase 0.0499 PF00068 Phospholipase A2 0.0354 PF03623 Focal adhesion targeting region 0.0329 PF06079 Apyrase 0.0097 PF02180 Bcl-2 homology region 4 0.0087 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0029 PF00149 Calcineurin-like phosphoesterase 0.0023 PF09292 Endonuclease VIII-like 1, DNA bind SUB631 O-C:C-O-C 0.6534 PF07690 Major Facilitator Superfamily 0.4879 PF00643 B-box zinc finger 0.3092 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.2196 PF00918 Gastrin/cholecystokinin family SUB277 B-O 0.6525 PF00227 Proteasome subunit SUB20 >= 2 O 0.6502 PF00821 Phosphoenolpyruvate carboxykinase 0.2675 PF03098 Animal haem peroxidase 0.2513 PF00625 Guanylate kinase 0.2052 PF00225 Kinesin motor domain 0.1496 PF00574 Clp protease 0.1302 PF00043 Glutathione S-transferase, C-terminal domain 0.1252 PF00084 Sushi domain (SCR repeat), 0.1242 PF00194 Eukaryotic-type carbonic anhydrase 0.1115 PF00489 Interleukin-6/G-CSF/MGF family 0.0609 PF00092 von Willebrand factor type A domain 0.0477 PF00337 Galactoside-binding lectin 0.0302 PF00520 Ion transport protein 0.0001 PF00001 7 transmembrane receptor (rhodopsin family), SUB379 C(~N)(:C)(:N) 0.6473 PF00186 Dihydrofolate reductase 0.3614 PF00858 Amiloride-sensitive sodium channel 0.3276 PF00156 Phosphoribosyl transferase domain 0.2771 PF03024 Folate receptor family 0.2461 PF01747 ATP-sulfurylase 0.2432 PF00962 Adenosine/AMP deaminase 0.0769 PF02803 Thiolase, C-terminal domain 0.0648 PF00069 Protein kinase domain 0.0233 PF02817 e3 binding domain 0.0005 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), SUB457 P(-O)(=O) 0.6415 PF01852 START domain 0.2533 PF00224 Pyruvate kinase, barrel domain 0.1305 PF00146 NADH dehydrogenase 0.1288 PF02441 Flavoprotein 0.1060 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.1030 PF00316 Fructose-1-6-bisphosphatase 0.1026 PF02666 Phosphatidylserine decarboxylase 0.0760 PF02886 LBP / BPI / CETP family, C-terminal domain 0.0588 PF00018 SH3 domain 0.0441 PF01467 Cytidylyltransferase 0.0223 PF00074 Pancreatic ribonuclease 0.0039 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0015 PF11404 Potassium voltage-gated channel SUB18 >= 8 N 0.6373 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.5460 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.3883 PF00184 Neurohypophysial hormones, C-terminal Domain 0.3097 PF00704 Glycosyl hydrolases family 18 0.1347 PF03308 ArgK protein 0.1178 PF02793 Hormone receptor domain 0.0061 PF00001 7 transmembrane receptor (rhodopsin family), 0.0003 PF01607 Chitin binding Peritrophin-A domain 0.0002 PF02310 B12 binding domain 0.0001 PF09193 Cholecystokinin A receptor, N-terminal 0.0001 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SUB7 >= 1 B 0.6357 PF00227 Proteasome subunit SUB644 [#1]-C-C-N-[#1] 0.6328 PF01536 Adenosylmethionine decarboxylase 0.3450 PF02166 Androgen receptor 0.3094 PF00324 Amino acid permease 0.2684 PF00074 Pancreatic ribonuclease 0.1518 PF00105 Zinc finger, C4 type (two domains), 0.1156 PF00209 Sodium:neurotransmitter symporter family 0.0944 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0872 PF00051 Kringle domain 0.0826 PF00204 DNA gyrase B 0.0630 PF03002 Somatostatin/Cortistatin family 0.0610 PF00089 Trypsin 0.0537 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0441 PF00112 Papain family cysteine protease 0.0423 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0199 PF00069 Protein kinase domain 0.0191 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0168 PF08070 DTHCT (NUC029), region 0.0155 PF01593 Flavin containing amine oxidoreductase 0.0143 PF00152 tRNA synthetases class II (D, K and N), 0.0118 PF01336 OB-fold nucleic acid binding domain 0.0001 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain SUB713 C-C(C)-C(C)-C 0.6289 PF00341 Platelet-derived growth factor (PDGF), 0.2644 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.2471 PF00079 Serpin (serine protease inhibitor), 0.2074 PF00291 Pyridoxal-phosphate dependent enzyme 0.1908 PF00489 Interleukin-6/G-CSF/MGF family 0.1420 PF00248 Aldo/keto reductase family 0.1148 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0977 PF00067 Cytochrome P450 0.0864 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0349 PF00571 CBS domain 0.0347 PF04622 ERG2 and Sigma1 receptor like protein 0.0320 PF02180 Bcl-2 homology region 4 0.0092 PF00497 Bacterial extracellular solute-binding proteins, family 3 SUB392 N(~C)(~C)(~C) 0.6269 PF08674 Acetylcholinesterase tetramerisation domain 0.2804 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.2580 PF00001 7 transmembrane receptor (rhodopsin family), 0.2507 PF00170 bZIP transcription factor 0.2457 PF01370 NAD dependent epimerase/dehydratase family 0.2456 PF00625 Guanylate kinase 0.2185 PF01467 Cytidylyltransferase 0.1835 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1777 PF00614 Phospholipase D Active site motif 0.1485 PF00145 C-5 cytosine-specific DNA methylase 0.1388 PF01633 Choline/ethanolamine kinase 0.1336 PF00209 Sodium:neurotransmitter symporter family 0.1019 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1014 PF00520 Ion transport protein 0.0850 PF00149 Calcineurin-like phosphoesterase 0.0517 PF06512 Sodium ion transport-associated 0.0454 PF01007 Inward rectifier potassium channel 0.0438 PF01569 PAP2 superfamily 0.0360 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0346 PF06888 Putative Phosphatase 0.0266 PF04515 Plasma-membrane choline transporter 0.0098 PF00105 Zinc finger, C4 type (two domains), 0.0001 PF00104 Ligand-binding domain of nuclear hormone receptor SUB14 >= 32 C 0.6245 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.5886 PF00493 MCM2/3/5 family 0.5137 PF00149 Calcineurin-like phosphoesterase 0.3554 PF08983 Domain of unknown function (DUF1856), 0.2813 PF02121 Phosphatidylinositol transfer protein 0.2661 PF00105 Zinc finger, C4 type (two domains), 0.2168 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.2004 PF02886 LBP / BPI / CETP family, C-terminal domain 0.1112 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0942 PF01273 LBP / BPI / CETP family, N-terminal domain 0.0806 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0762 PF06448 Domain of Unknown Function (DUF1081), 0.0526 PF00026 Eukaryotic aspartyl protease 0.0401 PF00067 Cytochrome P450 0.0287 PF00001 7 transmembrane receptor (rhodopsin family), 0.0001 PF09193 Cholecystokinin A receptor, N-terminal SUB594 N-C-C-C-N 0.6236 PF00583 Acetyltransferase (GNAT), family 0.4775 PF00149 Calcineurin-like phosphoesterase 0.4535 PF00089 Trypsin 0.4248 PF01564 Spermine/spermidine synthase 0.4043 PF00026 Eukaryotic aspartyl protease 0.1794 PF00067 Cytochrome P450 0.1626 PF00069 Protein kinase domain 0.0688 PF00057 Low-density lipoprotein receptor domain class A 0.0191 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0176 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0166 PF01571 Aminomethyltransferase folate-binding domain 0.0114 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0056 PF07966 A1 Propeptide 0.0021 PF02932 Neurotransmitter-gated ion-channel transmembrane region SUB96 >= 1 Hg 0.6224 PF00194 Eukaryotic-type carbonic anhydrase 0.3428 PF00171 Aldehyde dehydrogenase family 0.2945 PF06617 M-phase inducer phosphatase 0.2535 PF00754 F5/8 type C domain 0.2465 PF07732 Multicopper oxidase 0.1847 PF00337 Galactoside-binding lectin SUB408 O(~C)(~P) 0.6207 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.5928 PF00069 Protein kinase domain 0.5806 PF00168 C2 domain 0.5129 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.3878 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.3488 PF01130 CD36 family 0.2634 PF00343 Carbohydrate phosphorylase 0.2427 PF04716 ETC complex I subunit conserved region 0.2173 PF00459 Inositol monophosphatase family 0.1545 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.1028 PF01852 START domain 0.0825 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0778 PF02441 Flavoprotein 0.0738 PF00316 Fructose-1-6-bisphosphatase 0.0594 PF00169 PH domain 0.0386 PF01467 Cytidylyltransferase 0.0372 PF01023 S-100/ICaBP type calcium binding domain 0.0143 PF00074 Pancreatic ribonuclease 0.0129 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0056 PF00155 Aminotransferase class I and II 0.0046 PF02214 K+ channel tetramerisation domain 0.0044 PF00692 dUTPase 0.0022 PF11404 Potassium voltage-gated channel 0.0014 PF00248 Aldo/keto reductase family SUB757 Cc1c(O)cccc1 0.6197 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.4425 PF00005 ABC transporter 0.3680 PF00001 7 transmembrane receptor (rhodopsin family), 0.2999 PF01023 S-100/ICaBP type calcium binding domain 0.1813 PF00091 Tubulin/FtsZ family, GTPase domain 0.1408 PF00643 B-box zinc finger 0.1343 PF03953 Tubulin C-terminal domain 0.0688 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0412 PF02932 Neurotransmitter-gated ion-channel transmembrane region SUB200 >= 4 any ring size 6 0.6197 PF00520 Ion transport protein 0.4100 PF00043 Glutathione S-transferase, C-terminal domain 0.4064 PF00089 Trypsin 0.3241 PF00069 Protein kinase domain 0.2881 PF00170 bZIP transcription factor 0.2124 PF00357 Integrin alpha cytoplasmic region 0.1795 PF02525 Flavodoxin-like fold 0.1777 PF00689 Cation transporting ATPase, C-terminus 0.1547 PF00690 Cation transporter/ATPase, N-terminus 0.1448 PF01593 Flavin containing amine oxidoreductase 0.1334 PF08384 Pro-opiomelanocortin, N-terminal region 0.1232 PF00122 E1-E2 ATPase 0.0706 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0653 PF08763 Voltage gated calcium channel IQ domain 0.0201 PF00976 Corticotropin ACTH domain 0.0177 PF00001 7 transmembrane receptor (rhodopsin family), SUB437 C(-C)(-H)(=O) 0.6185 PF00089 Trypsin 0.2509 PF00702 haloacid dehalogenase-like hydrolase 0.1496 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0053 PF00291 Pyridoxal-phosphate dependent enzyme SUB692 O-C-C-C-C-C-N 0.6148 PF01168 Alanine racemase, N-terminal domain 0.5234 PF00085 Thioredoxin 0.4749 PF00209 Sodium:neurotransmitter symporter family 0.4192 PF00491 Arginase family 0.2353 PF03807 NADP oxidoreductase coenzyme F420-dependent 0.2283 PF00337 Galactoside-binding lectin 0.1400 PF02100 Ornithine decarboxylase antizyme 0.1264 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.1252 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.1106 PF00927 Transglutaminase family, C-terminal ig like domain 0.0999 PF00001 7 transmembrane receptor (rhodopsin family), 0.0961 PF01842 ACT domain 0.0213 PF00764 Arginosuccinate synthase 0.0197 PF03950 tRNA synthetases class I (E and Q), , anti-codon binding domain 0.0001 PF00619 Caspase recruitment domain SUB460 S(=O)(=O) 0.6140 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.5546 PF00520 Ion transport protein 0.4142 PF08399 VWA N-terminal 0.0782 PF03098 Animal haem peroxidase 0.0377 PF00092 von Willebrand factor type A domain 0.0196 PF00625 Guanylate kinase 0.0023 PF00822 PMP-22/EMP/MP20/Claudin family SUB633 C-C-O-C:C 0.6135 PF08441 Integrin alpha 0.3353 PF01023 S-100/ICaBP type calcium binding domain 0.3026 PF00105 Zinc finger, C4 type (two domains), 0.1328 PF00102 Protein-tyrosine phosphatase 0.0943 PF00650 CRAL/TRIO domain 0.0921 PF00149 Calcineurin-like phosphoesterase 0.0850 PF02885 Glycosyl transferase family, helical bundle domain 0.0846 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0719 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0492 PF00001 7 transmembrane receptor (rhodopsin family), 0.0487 PF07831 Pyrimidine nucleoside phosphorylase C-terminal domain 0.0313 PF00591 Glycosyl transferase family, a/b domain 0.0295 PF00079 Serpin (serine protease inhibitor), 0.0112 PF00248 Aldo/keto reductase family 0.0077 PF03765 CRAL/TRIO, N-terminus 0.0077 PF00561 alpha/beta hydrolase fold 0.0036 PF01030 Receptor L domain SUB302 N-O 0.6107 PF00850 Histone deacetylase domain 0.0825 PF01327 Polypeptide deformylase 0.0040 PF01180 Dihydroorotate dehydrogenase 0.0005 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like SUB759 Cc1c(N)cccc1 0.6082 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.3537 PF00305 Lipoxygenase 0.2314 PF01582 TIR domain 0.2216 PF00017 SH2 domain 0.1596 PF00005 ABC transporter 0.1538 PF01231 Indoleamine 2,3-dioxygenase 0.0963 PF00001 7 transmembrane receptor (rhodopsin family), 0.0773 PF01401 Angiotensin-converting enzyme 0.0624 PF00579 tRNA synthetases class I (W and Y), 0.0430 PF01030 Receptor L domain 0.0149 PF01387 Synuclein 0.0002 PF01404 Ephrin receptor ligand binding domain SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 0.6060 PF00676 Dehydrogenase E1 component 0.5910 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.5116 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.4750 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.4143 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.4083 PF02466 Tim17/Tim22/Tim23 family 0.4049 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.3421 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.3180 PF06212 GRIM-19 protein 0.3002 PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 0.2897 PF09166 Biliverdin reductase, catalytic 0.2806 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.2128 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.2088 PF00146 NADH dehydrogenase 0.2062 PF05347 Complex 1 protein (LYR family), 0.1950 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.1912 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.1888 PF04116 Fatty acid hydroxylase superfamily 0.1801 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.1653 PF10276 Zinc-finger domain 0.1503 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.1461 PF10531 SLBB domain 0.1436 PF09326 Domain of unknown function (DUF1982), 0.1366 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.1278 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.1252 PF00175 Oxidoreductase NAD-binding domain 0.1251 PF00171 Aldehyde dehydrogenase family 0.1016 PF02779 Transketolase, pyrimidine binding domain 0.0919 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0908 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0849 PF04800 ETC complex I subunit conserved region 0.0719 PF00248 Aldo/keto reductase family 0.0614 PF03807 NADP oxidoreductase coenzyme F420-dependent 0.0534 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0436 PF00067 Cytochrome P450 0.0357 PF08040 MNLL subunit 0.0250 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0207 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0201 PF03404 Mo-co oxidoreductase dimerisation domain 0.0133 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0038 PF00209 Sodium:neurotransmitter symporter family SUB603 O=C-C-N-C 0.6052 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 0.4791 PF00089 Trypsin 0.3980 PF00151 Lipase 0.2296 PF03171 2OG-Fe(II), oxygenase superfamily 0.2245 PF01619 Proline dehydrogenase 0.2099 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.2038 PF00102 Protein-tyrosine phosphatase 0.1999 PF00999 Sodium/hydrogen exchanger family 0.1310 PF01327 Polypeptide deformylase 0.1119 PF00217 ATP:guanido phosphotransferase, C-terminal catalytic domain 0.1079 PF00149 Calcineurin-like phosphoesterase 0.1027 PF00653 Inhibitor of Apoptosis domain 0.0899 PF00045 Hemopexin 0.0820 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0704 PF00413 Matrixin 0.0688 PF02798 Glutathione S-transferase, N-terminal domain 0.0145 PF06512 Sodium ion transport-associated 0.0044 PF02807 ATP:guanido phosphotransferase, N-terminal domain SUB642 O-C-C-C=C 0.6044 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.2290 PF00989 PAS fold 0.2221 PF00069 Protein kinase domain 0.2128 PF00149 Calcineurin-like phosphoesterase 0.0770 PF03098 Animal haem peroxidase 0.0463 PF00027 Cyclic nucleotide-binding domain 0.0325 PF00362 Integrin, beta chain 0.0274 PF08725 Integrin beta cytoplasmic domain 0.0245 PF00413 Matrixin 0.0058 PF00071 Ras family 0.0003 PF07965 Integrin beta tail domain SUB576 O-C-C:C-O 0.6010 PF00171 Aldehyde dehydrogenase family 0.0904 PF00656 Caspase domain 0.0738 PF00571 CBS domain 0.0008 PF00001 7 transmembrane receptor (rhodopsin family), SUB484 N-S-C:C 0.5997 PF00324 Amino acid permease 0.2003 PF00194 Eukaryotic-type carbonic anhydrase 0.1657 PF08403 Amino acid permease N-terminal SUB548 N-C:C-N 0.5992 PF01687 Riboflavin kinase 0.3082 PF00962 Adenosine/AMP deaminase 0.1184 PF01590 GAF domain 0.1060 PF04389 Peptidase family M28 0.0859 PF05995 Cysteine dioxygenase type I 0.0733 PF01923 Cobalamin adenosyltransferase 0.0694 PF00156 Phosphoribosyl transferase domain 0.0687 PF00221 Phenylalanine and histidine ammonia-lyase 0.0635 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0603 PF00501 AMP-binding enzyme 0.0574 PF00001 7 transmembrane receptor (rhodopsin family), 0.0061 PF00153 Mitochondrial carrier protein SUB341 C(~C)(~C)(~N) 0.5970 PF00291 Pyridoxal-phosphate dependent enzyme 0.2656 PF06512 Sodium ion transport-associated 0.1536 PF00117 Glutamine amidotransferase class-I 0.1347 PF00310 Glutamine amidotransferases class-II 0.1286 PF00156 Phosphoribosyl transferase domain 0.1032 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.1020 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1014 PF00155 Aminotransferase class I and II 0.0769 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0569 PF07686 Immunoglobulin V-set domain 0.0265 PF00709 Adenylosuccinate synthetase 0.0098 PF00324 Amino acid permease SUB698 C-C-C-C-C-C(C)-C 0.5966 PF00149 Calcineurin-like phosphoesterase 0.4486 PF00413 Matrixin 0.3973 PF00106 short chain dehydrogenase 0.2658 PF08127 Peptidase family C1 propeptide 0.2408 PF00664 ABC transporter transmembrane region 0.2025 PF00520 Ion transport protein 0.1516 PF00005 ABC transporter 0.0810 PF00092 von Willebrand factor type A domain 0.0622 PF00026 Eukaryotic aspartyl protease 0.0504 PF03765 CRAL/TRIO, N-terminus 0.0463 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0091 PF00209 Sodium:neurotransmitter symporter family 0.0034 PF00650 CRAL/TRIO domain SUB727 Sc1ccc(Cl)cc1 0.5959 PF00067 Cytochrome P450 SUB520 N=C-N-C 0.5953 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.3171 PF01048 Phosphorylase superfamily 0.3003 PF02310 B12 binding domain 0.0424 PF00209 Sodium:neurotransmitter symporter family SUB444 C(-C)(=O) 0.5948 PF02166 Androgen receptor 0.4385 PF00202 Aminotransferase class-III 0.3273 PF00266 Aminotransferase class-V 0.3101 PF00074 Pancreatic ribonuclease 0.2534 PF00413 Matrixin 0.2148 PF00390 Malic enzyme, N-terminal domain 0.1937 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.1581 PF00248 Aldo/keto reductase family 0.1501 PF01433 Peptidase family M1 0.1452 PF00001 7 transmembrane receptor (rhodopsin family), 0.1282 PF06512 Sodium ion transport-associated 0.1202 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1083 PF08070 DTHCT (NUC029), region 0.0893 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0725 PF00557 Metallopeptidase family M24 0.0661 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0578 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0538 PF00571 CBS domain 0.0538 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0487 PF03949 Malic enzyme, NAD binding domain 0.0407 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0290 PF00089 Trypsin 0.0263 PF00929 Exonuclease 0.0194 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0178 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0040 PF00273 Serum albumin family 0.0032 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0016 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0008 PF02347 Glycine cleavage system P-protein 0.0004 PF01212 Beta-eliminating lyase SUB606 O=C-C-O-C 0.5921 PF00354 Pentaxin family 0.5000 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.4310 PF00001 7 transmembrane receptor (rhodopsin family), 0.3001 PF00520 Ion transport protein 0.1819 PF08429 PLU-1-like protein 0.1287 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.1106 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0757 PF01388 ARID/BRIGHT DNA binding domain 0.0680 PF03171 2OG-Fe(II), oxygenase superfamily 0.0598 PF02928 C5HC2 zinc finger 0.0575 PF00628 PHD-finger 0.0541 PF02375 jmjN domain 0.0205 PF02260 FATC domain 0.0014 PF02373 JmjC domain 0.0002 PF08771 Rapamycin binding domain SUB554 O=C-C=C 0.5915 PF00464 Serine hydroxymethyltransferase 0.1752 PF02525 Flavodoxin-like fold 0.1016 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0891 PF00821 Phosphoenolpyruvate carboxykinase 0.0779 PF00171 Aldehyde dehydrogenase family 0.0572 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0454 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0080 PF08403 Amino acid permease N-terminal SUB814 NC1CC(Cl)CCC1 0.5906 PF00043 Glutathione S-transferase, C-terminal domain 0.2018 PF02254 TrkA-N domain 0.0404 PF00209 Sodium:neurotransmitter symporter family 0.0016 PF00168 C2 domain 0.0015 PF03493 Calcium-activated BK potassium channel alpha subunit SUB13 >= 16 C 0.5890 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.4591 PF00171 Aldehyde dehydrogenase family 0.2664 PF00104 Ligand-binding domain of nuclear hormone receptor 0.2257 PF00067 Cytochrome P450 0.2140 PF00501 AMP-binding enzyme 0.1854 PF03765 CRAL/TRIO, N-terminus 0.1317 PF00001 7 transmembrane receptor (rhodopsin family), 0.1188 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.1137 PF00489 Interleukin-6/G-CSF/MGF family 0.0945 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0923 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0845 PF00106 short chain dehydrogenase 0.0759 PF00650 CRAL/TRIO domain 0.0552 PF00487 Fatty acid desaturase 0.0528 PF00043 Glutathione S-transferase, C-terminal domain 0.0304 PF00248 Aldo/keto reductase family SUB598 O=C-C-C:C 0.5865 PF06512 Sodium ion transport-associated 0.1979 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1928 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0518 PF07884 Vitamin K epoxide reductase family 0.0308 PF03098 Animal haem peroxidase 0.0102 PF08403 Amino acid permease N-terminal 0.0011 PF00089 Trypsin SUB588 N-C:C-O-[#1] 0.5850 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.5688 PF00266 Aminotransferase class-V 0.5037 PF00001 7 transmembrane receptor (rhodopsin family), 0.5029 PF00294 pfkB family carbohydrate kinase 0.4509 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.4327 PF00155 Aminotransferase class I and II 0.0001 PF02347 Glycine cleavage system P-protein SUB841 CC1CC(O)CC1 0.5810 PF00001 7 transmembrane receptor (rhodopsin family), 0.1834 PF08377 MAP2/Tau projection domain 0.0020 PF00418 Tau and MAP protein, tubulin-binding repeat SUB688 O=C-C-C-C=O 0.5780 PF00549 CoA-ligase 0.5729 PF00271 Helicase conserved C-terminal domain 0.5724 PF01144 Coenzyme A transferase 0.5169 PF05118 Aspartyl/Asparaginyl beta-hydroxylase 0.4404 PF00229 TNF(Tumour Necrosis Factor), family 0.3661 PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit 0.3659 PF01112 Asparaginase 0.3379 PF01546 Peptidase family M20/M25/M40 0.3359 PF04952 Succinylglutamate desuccinylase / Aspartoacylase family 0.2655 PF00890 FAD binding domain 0.2270 PF00005 ABC transporter 0.1947 PF00731 AIR carboxylase 0.1637 PF00939 Sodium:sulfate symporter transmembrane region 0.1621 PF07687 Peptidase dimerisation domain 0.1541 PF00106 short chain dehydrogenase 0.1333 PF02910 domain 0.1091 PF04756 OST3 / OST6 family 0.1013 PF00001 7 transmembrane receptor (rhodopsin family), 0.0369 PF01259 SAICAR synthetase 0.0322 PF00023 Ankyrin repeat 0.0214 PF00709 Adenylosuccinate synthetase SUB386 C(:C)(:C)(:C) 0.5770 PF01387 Synuclein 0.5051 PF01582 TIR domain 0.4152 PF00989 PAS fold 0.2695 PF08491 Squalene epoxidase 0.2199 PF00001 7 transmembrane receptor (rhodopsin family), 0.0589 PF00305 Lipoxygenase 0.0441 PF00051 Kringle domain SUB572 [#1]-C-O-[#1] 0.5759 PF00342 Phosphoglucose isomerase 0.5435 PF01066 CDP-alcohol phosphatidyltransferase 0.4498 PF01607 Chitin binding Peritrophin-A domain 0.4459 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.3856 PF04515 Plasma-membrane choline transporter 0.3764 PF07653 Variant SH3 domain 0.2998 PF00400 WD domain, G-beta repeat 0.2857 PF00191 Annexin 0.2765 PF00704 Glycosyl hydrolases family 18 0.2550 PF00145 C-5 cytosine-specific DNA methylase 0.2440 PF01633 Choline/ethanolamine kinase 0.2426 PF00714 Interferon gamma 0.2408 PF00167 Fibroblast growth factor 0.2329 PF00069 Protein kinase domain 0.2286 PF00212 Atrial natriuretic peptide 0.2202 PF06888 Putative Phosphatase 0.2170 PF02065 Melibiase 0.2109 PF00931 NB-ARC domain 0.2092 PF01462 Leucine rich repeat N-terminal domain 0.2058 PF00019 Transforming growth factor beta like domain 0.1566 PF00059 Lectin C-type domain 0.1527 PF01467 Cytidylyltransferase 0.1484 PF00614 Phospholipase D Active site motif 0.1449 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.1390 PF00688 TGF-beta propeptide 0.1278 PF00265 Thymidine kinase 0.1263 PF01569 PAP2 superfamily 0.1262 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.1131 PF00001 7 transmembrane receptor (rhodopsin family), 0.1049 PF01370 NAD dependent epimerase/dehydratase family 0.1019 PF08240 Alcohol dehydrogenase GroES-like domain 0.0923 PF00520 Ion transport protein 0.0891 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0839 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0838 PF01369 Sec7 domain 0.0748 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0656 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0580 PF03781 Formylglycine-generating sulfatase enzyme 0.0566 PF00079 Serpin (serine protease inhibitor), 0.0496 PF07686 Immunoglobulin V-set domain 0.0385 PF00041 Fibronectin type III domain 0.0384 PF00236 Glycoprotein hormone 0.0282 PF01048 Phosphorylase superfamily 0.0153 PF00732 GMC oxidoreductase 0.0145 PF00303 Thymidylate synthase 0.0132 PF05199 GMC oxidoreductase 0.0100 PF01433 Peptidase family M1 0.0034 PF03572 Peptidase family S41 0.0006 PF00005 ABC transporter 0.0005 PF02806 Alpha amylase, C-terminal all-beta domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain SUB346 C(~C)(~H)(~N) 0.5755 PF00209 Sodium:neurotransmitter symporter family 0.3982 PF02159 Oestrogen receptor 0.2218 PF03073 TspO/MBR family 0.1234 PF00001 7 transmembrane receptor (rhodopsin family), 0.1207 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 0.1077 PF00664 ABC transporter transmembrane region 0.1062 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0969 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0529 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0446 PF00194 Eukaryotic-type carbonic anhydrase 0.0334 PF00005 ABC transporter 0.0318 PF04389 Peptidase family M28 0.0290 PF00464 Serine hydroxymethyltransferase 0.0155 PF00024 PAN domain SUB413 S(~C)(~C) 0.5736 PF04321 RmlD substrate binding domain 0.4533 PF00186 Dihydrofolate reductase 0.3638 PF01625 Peptide methionine sulfoxide reductase 0.3213 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.2672 PF09334 tRNA synthetases class I (M), 0.1332 PF02574 Homocysteine S-methyltransferase 0.1257 PF12497 Estrogen receptor beta 0.1077 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0458 PF01641 SelR domain SUB799 CC1CC(O)CCC1 0.5727 PF00520 Ion transport protein 0.5124 PF00168 C2 domain 0.1483 PF00305 Lipoxygenase 0.0272 PF00225 Kinesin motor domain 0.0255 PF01735 Lysophospholipase catalytic domain 0.0189 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0157 PF02180 Bcl-2 homology region 4 0.0104 PF00209 Sodium:neurotransmitter symporter family SUB469 O=S-C-N 0.5681 PF00287 Sodium / potassium ATPase beta chain SUB132 >= 1 saturated or aromatic nitrogen-containing ring size 4 0.5642 PF00854 POT family 0.4788 PF02460 Patched family 0.0528 PF01433 Peptidase family M1 SUB365 C(~F)(:C) 0.5642 PF00069 Protein kinase domain 0.3662 PF00493 MCM2/3/5 family 0.0683 PF00071 Ras family SUB783 OC1CCC(O)CC1 0.5636 PF00459 Inositol monophosphatase family 0.5000 PF00031 Cystatin domain 0.2457 PF01363 FYVE zinc finger 0.2176 PF01733 Nucleoside transporter 0.2093 PF00501 AMP-binding enzyme SUB636 N-N-C-N-[#1] 0.5635 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 0.0483 PF00520 Ion transport protein SUB422 C=S 0.5630 PF07645 Calcium-binding EGF domain 0.0238 PF00001 7 transmembrane receptor (rhodopsin family), SUB715 Cc1ccc(O)cc1 0.5611 PF00105 Zinc finger, C4 type (two domains), 0.4783 PF00017 SH2 domain 0.2978 PF03062 MBOAT family 0.1967 PF00018 SH3 domain 0.1058 PF08441 Integrin alpha 0.0551 PF00001 7 transmembrane receptor (rhodopsin family), SUB381 C(~O)(~O) 0.5576 PF00405 Transferrin 0.4964 PF01401 Angiotensin-converting enzyme 0.4873 PF10420 Cytokine interleukin-12p40 C-terminus 0.4595 PF00058 Low-density lipoprotein receptor repeat class B 0.2380 PF00224 Pyruvate kinase, barrel domain 0.2340 PF00105 Zinc finger, C4 type (two domains), 0.1816 PF07654 Immunoglobulin C1-set domain 0.1771 PF00051 Kringle domain 0.1576 PF00248 Aldo/keto reductase family 0.1350 PF00560 Leucine Rich Repeat 0.1314 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.1000 PF00128 Alpha amylase, catalytic domain 0.0703 PF00209 Sodium:neurotransmitter symporter family 0.0478 PF00005 ABC transporter 0.0360 PF07686 Immunoglobulin V-set domain 0.0358 PF00001 7 transmembrane receptor (rhodopsin family), 0.0269 PF00067 Cytochrome P450 0.0244 PF01590 GAF domain 0.0001 PF07706 Aminotransferase ubiquitination site SUB36 >= 4 S 0.5528 PF00171 Aldehyde dehydrogenase family 0.3477 PF00089 Trypsin 0.1891 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.1068 PF03073 TspO/MBR family SUB367 C(~H)(~O) 0.5520 PF02214 K+ channel tetramerisation domain 0.3190 PF00107 Zinc-binding dehydrogenase 0.2390 PF00069 Protein kinase domain 0.2214 PF00574 Clp protease 0.2083 PF00059 Lectin C-type domain 0.0812 PF00043 Glutathione S-transferase, C-terminal domain 0.0386 PF06512 Sodium ion transport-associated 0.0343 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0018 PF00084 Sushi domain (SCR repeat), SUB696 O=C-C-C-C-C-N 0.5514 PF00026 Eukaryotic aspartyl protease 0.4548 PF00490 Delta-aminolevulinic acid dehydratase 0.4232 PF02100 Ornithine decarboxylase antizyme 0.3859 PF00653 Inhibitor of Apoptosis domain 0.3181 PF05544 Proline racemase 0.2973 PF02274 Amidinotransferase 0.2692 PF00491 Arginase family 0.2272 PF08983 Domain of unknown function (DUF1856), 0.1935 PF00756 Putative esterase 0.1883 PF00153 Mitochondrial carrier protein 0.0997 PF08527 Protein-arginine deiminase (PAD), middle domain 0.0724 PF03068 Protein-arginine deiminase (PAD), 0.0694 PF08526 Protein-arginine deiminase (PAD), N-terminal domain 0.0688 PF01467 Cytidylyltransferase 0.0649 PF00058 Low-density lipoprotein receptor repeat class B 0.0618 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0562 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0483 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0280 PF07645 Calcium-binding EGF domain 0.0249 PF00079 Serpin (serine protease inhibitor), 0.0137 PF01124 MAPEG family 0.0095 PF00149 Calcineurin-like phosphoesterase SUB535 S-C:C-O 0.5502 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0740 PF00001 7 transmembrane receptor (rhodopsin family), SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 0.5480 PF00106 short chain dehydrogenase 0.5226 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.2377 PF01234 NNMT/PNMT/TEMT family 0.2210 PF00531 Death domain 0.1749 PF00001 7 transmembrane receptor (rhodopsin family), 0.1593 PF07690 Major Facilitator Superfamily 0.1553 PF04622 ERG2 and Sigma1 receptor like protein 0.0541 PF03171 2OG-Fe(II), oxygenase superfamily 0.0502 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0003 PF02196 Raf-like Ras-binding domain 0.0001 PF02173 pKID domain SUB660 O-C-C-N-C 0.5477 PF01467 Cytidylyltransferase 0.3767 PF04515 Plasma-membrane choline transporter 0.3754 PF00067 Cytochrome P450 0.2980 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 0.2906 PF00614 Phospholipase D Active site motif 0.2206 PF01401 Angiotensin-converting enzyme 0.2182 PF00551 Formyl transferase 0.2052 PF05199 GMC oxidoreductase 0.1936 PF01633 Choline/ethanolamine kinase 0.1762 PF00755 Choline/Carnitine o-acyltransferase 0.1682 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.1373 PF00702 haloacid dehalogenase-like hydrolase 0.1330 PF02807 ATP:guanido phosphotransferase, N-terminal domain 0.0931 PF00001 7 transmembrane receptor (rhodopsin family), 0.0866 PF01619 Proline dehydrogenase 0.0718 PF01569 PAP2 superfamily 0.0495 PF00664 ABC transporter transmembrane region 0.0434 PF06888 Putative Phosphatase 0.0361 PF00005 ABC transporter 0.0272 PF00255 Glutathione peroxidase 0.0059 PF00209 Sodium:neurotransmitter symporter family SUB714 Cc1ccc(C)cc1 0.5477 PF00017 SH2 domain 0.2081 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.1202 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0822 PF00754 F5/8 type C domain 0.0594 PF00018 SH3 domain 0.0020 PF00105 Zinc finger, C4 type (two domains), SUB708 O=C-C-C-C-C(N)-C 0.5450 PF02219 Methylenetetrahydrofolate reductase 0.4533 PF02310 B12 binding domain 0.3759 PF01426 BAH domain 0.3251 PF03024 Folate receptor family 0.3170 PF00850 Histone deacetylase domain 0.2933 PF07690 Major Facilitator Superfamily 0.0674 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0652 PF01403 Sema domain 0.0570 PF00017 SH2 domain 0.0346 PF00084 Sushi domain (SCR repeat), 0.0297 PF01571 Aminomethyltransferase folate-binding domain 0.0220 PF01437 Plexin repeat 0.0218 PF00092 von Willebrand factor type A domain 0.0155 PF00464 Serine hydroxymethyltransferase 0.0111 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0083 PF01833 IPT/TIG domain SUB673 O=C-C=C-[#1] 0.5429 PF00531 Death domain 0.2665 PF00171 Aldehyde dehydrogenase family 0.2638 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.1738 PF07884 Vitamin K epoxide reductase family 0.1568 PF01042 Endoribonuclease L-PSP 0.1457 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.1329 PF01571 Aminomethyltransferase folate-binding domain 0.1270 PF00229 TNF(Tumour Necrosis Factor), family 0.1181 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0863 PF00001 7 transmembrane receptor (rhodopsin family), 0.0856 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0706 PF00089 Trypsin 0.0594 PF01467 Cytidylyltransferase 0.0558 PF07686 Immunoglobulin V-set domain 0.0472 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0062 PF00622 SPRY domain 0.0030 PF00194 Eukaryotic-type carbonic anhydrase 0.0026 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0020 PF00056 lactate/malate dehydrogenase, NAD binding domain SUB834 NC1C(N)CCCC1 0.5398 PF01923 Cobalamin adenosyltransferase 0.0732 PF00001 7 transmembrane receptor (rhodopsin family), 0.0724 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0050 PF01403 Sema domain SUB707 O=C-C-C-C-C(=O)-C 0.5388 PF02059 Interleukin-3 0.4996 PF00001 7 transmembrane receptor (rhodopsin family), 0.3402 PF00377 Prion/Doppel alpha-helical domain SUB201 >= 4 saturated or aromatic carbon-only ring size 6 0.5352 PF00001 7 transmembrane receptor (rhodopsin family), 0.2063 PF00105 Zinc finger, C4 type (two domains), 0.1744 PF01160 Vertebrate endogenous opioids neuropeptide 0.0622 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0080 PF02932 Neurotransmitter-gated ion-channel transmembrane region SUB623 O=C-O-C:C 0.5340 PF00067 Cytochrome P450 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 0.5320 PF00069 Protein kinase domain 0.4715 PF00229 TNF(Tumour Necrosis Factor), family 0.4561 PF00041 Fibronectin type III domain 0.4217 PF00059 Lectin C-type domain 0.3354 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.2964 PF00501 AMP-binding enzyme 0.2949 PF00560 Leucine Rich Repeat 0.2439 PF00248 Aldo/keto reductase family 0.2112 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.2054 PF07654 Immunoglobulin C1-set domain 0.1911 PF00135 Carboxylesterase 0.1622 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1525 PF00714 Interferon gamma 0.1290 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1207 PF03727 Hexokinase 0.1174 PF00045 Hemopexin 0.1128 PF00349 Hexokinase 0.1035 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0861 PF01471 Putative peptidoglycan binding domain 0.0725 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0617 PF08070 DTHCT (NUC029), region 0.0402 PF00089 Trypsin 0.0221 PF08725 Integrin beta cytoplasmic domain 0.0081 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0043 PF02173 pKID domain 0.0039 PF00405 Transferrin SUB431 C(-C)(-C)(=C) 0.5319 PF00171 Aldehyde dehydrogenase family 0.4168 PF01593 Flavin containing amine oxidoreductase 0.2950 PF02525 Flavodoxin-like fold 0.1248 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.1145 PF00069 Protein kinase domain 0.0926 PF00175 Oxidoreductase NAD-binding domain 0.0795 PF00667 FAD binding domain 0.0756 PF00067 Cytochrome P450 0.0427 PF00079 Serpin (serine protease inhibitor), SUB356 C(~C)(:C) 0.5316 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.3503 PF00001 7 transmembrane receptor (rhodopsin family), SUB516 N-N-C-C 0.5295 PF00664 ABC transporter transmembrane region 0.3609 PF00079 Serpin (serine protease inhibitor), 0.1541 PF02025 Interleukin 5 SUB359 C(~C)(:N) 0.5282 PF00001 7 transmembrane receptor (rhodopsin family), 0.0446 PF00531 Death domain 0.0139 PF00229 TNF(Tumour Necrosis Factor), family SUB735 Cc1cc(C)ccc1 0.5269 PF01030 Receptor L domain 0.3629 PF00757 Furin-like cysteine rich region 0.2480 PF00105 Zinc finger, C4 type (two domains), 0.1484 PF00089 Trypsin 0.0865 PF03098 Animal haem peroxidase 0.0846 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0753 PF08491 Squalene epoxidase 0.0750 PF00069 Protein kinase domain 0.0394 PF00664 ABC transporter transmembrane region 0.0164 PF00501 AMP-binding enzyme SUB651 O=C-N-C=O 0.5189 PF00520 Ion transport protein 0.2235 PF00343 Carbohydrate phosphorylase 0.2037 PF03360 Glycosyltransferase family 43 0.1947 PF00001 7 transmembrane receptor (rhodopsin family), SUB187 >= 2 saturated or aromatic carbon-only ring size 6 0.5144 PF02159 Oestrogen receptor 0.2742 PF00561 alpha/beta hydrolase fold 0.2275 PF03520 KCNQ voltage-gated potassium channel 0.1953 PF00664 ABC transporter transmembrane region 0.1314 PF00001 7 transmembrane receptor (rhodopsin family), 0.1166 PF08035 Opioids neuropeptide 0.1047 PF01030 Receptor L domain 0.1043 PF00989 PAS fold 0.0582 PF00576 HIUase/Transthyretin family 0.0507 PF00112 Papain family cysteine protease 0.0499 PF00976 Corticotropin ACTH domain 0.0211 PF00204 DNA gyrase B 0.0209 PF08384 Pro-opiomelanocortin, N-terminal region 0.0103 PF00248 Aldo/keto reductase family 0.0070 PF00757 Furin-like cysteine rich region SUB439 C(-C)(-N)(=N) 0.5129 PF00406 Adenylate kinase 0.1561 PF10391 Fingers domain of DNA polymerase lambda 0.1491 PF03171 2OG-Fe(II), oxygenase superfamily 0.1382 PF00571 CBS domain 0.1194 PF01687 Riboflavin kinase 0.1190 PF00089 Trypsin 0.0752 PF01747 ATP-sulfurylase 0.0266 PF04042 DNA polymerase alpha/epsilon subunit B 0.0210 PF08418 DNA polymerase alpha subunit B N-terminal 0.0190 PF01591 6-phosphofructo-2-kinase 0.0137 PF00931 NB-ARC domain 0.0074 PF00300 Phosphoglycerate mutase family SUB490 N-C-S-C 0.5112 PF02189 Immunoreceptor tyrosine-based activation motif 0.4888 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.3152 PF01733 Nucleoside transporter 0.3053 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0900 PF04679 ATP dependent DNA ligase C terminal region 0.0560 PF01068 ATP dependent DNA ligase domain SUB250 >= 1 saturated or aromatic carbon-only ring size 10 0.5103 PF06327 Domain of Unknown Function (DUF1053), 0.4627 PF08491 Squalene epoxidase 0.0415 PF00092 von Willebrand factor type A domain 0.0343 PF00248 Aldo/keto reductase family 0.0200 PF00067 Cytochrome P450 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 0.5099 PF00364 Biotin-requiring enzyme 0.1689 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.1635 PF00005 ABC transporter 0.1330 PF01234 NNMT/PNMT/TEMT family 0.1151 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0976 PF00571 CBS domain 0.0846 PF08040 MNLL subunit 0.0716 PF00001 7 transmembrane receptor (rhodopsin family), 0.0679 PF00211 Adenylate and Guanylate cyclase catalytic domain 0.0207 PF00664 ABC transporter transmembrane region 0.0005 PF01591 6-phosphofructo-2-kinase SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 0.5081 PF00501 AMP-binding enzyme 0.5059 PF03807 NADP oxidoreductase coenzyme F420-dependent 0.3732 PF00069 Protein kinase domain 0.1509 PF00520 Ion transport protein 0.1113 PF00341 Platelet-derived growth factor (PDGF), 0.0917 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 0.0760 PF01731 Arylesterase 0.0495 PF05544 Proline racemase 0.0192 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0007 PF02932 Neurotransmitter-gated ion-channel transmembrane region SUB705 O=C-C-C-C-C-C-C 0.5065 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.2537 PF00092 von Willebrand factor type A domain 0.2296 PF01431 Peptidase family M13 0.1919 PF08127 Peptidase family C1 propeptide 0.1351 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.1275 PF00579 tRNA synthetases class I (W and Y), 0.0809 PF03099 Biotin/lipoate A/B protein ligase family 0.0771 PF00474 Sodium:solute symporter family 0.0600 PF00026 Eukaryotic aspartyl protease 0.0495 PF04704 Zfx / Zfy transcription activation region 0.0462 PF00362 Integrin, beta chain 0.0439 PF08725 Integrin beta cytoplasmic domain 0.0247 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0246 PF00096 Zinc finger, C2H2 type 0.0087 PF07965 Integrin beta tail domain SUB350 C(~C)(~H)(~S) 0.5018 PF00245 Alkaline phosphatase 0.4363 PF02798 Glutathione S-transferase, N-terminal domain 0.3195 PF09334 tRNA synthetases class I (M), 0.3191 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.2853 PF01641 SelR domain 0.2835 PF00184 Neurohypophysial hormones, C-terminal Domain 0.2722 PF12497 Estrogen receptor beta 0.2460 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.2418 PF00059 Lectin C-type domain 0.2182 PF08725 Integrin beta cytoplasmic domain 0.2130 PF01323 DSBA-like thioredoxin domain 0.1959 PF03099 Biotin/lipoate A/B protein ligase family 0.1496 PF00474 Sodium:solute symporter family 0.0851 PF06617 M-phase inducer phosphatase 0.0840 PF00557 Metallopeptidase family M24 0.0708 PF08441 Integrin alpha 0.0699 PF00581 Rhodanese-like domain 0.0566 PF05995 Cysteine dioxygenase type I 0.0417 PF00043 Glutathione S-transferase, C-terminal domain 0.0265 PF00084 Sushi domain (SCR repeat), 0.0118 PF00756 Putative esterase 0.0036 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0033 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0033 PF00362 Integrin, beta chain 0.0032 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF07965 Integrin beta tail domain SUB771 Nc1c(N)cccc1 0.5007 PF00792 Phosphoinositide 3-kinase C2 0.2905 PF01687 Riboflavin kinase 0.1025 PF01437 Plexin repeat 0.0746 PF01923 Cobalamin adenosyltransferase 0.0721 PF01833 IPT/TIG domain 0.0660 PF00175 Oxidoreductase NAD-binding domain 0.0001 PF00454 Phosphatidylinositol 3- and 4-kinase SUB66 >= 1 As 0.5000 PF07970 Endoplasmic reticulum vesicle transporter 0.5000 PF00170 bZIP transcription factor 0.4495 PF00005 ABC transporter 0.3266 PF08240 Alcohol dehydrogenase GroES-like domain 0.1425 PF01161 Phosphatidylethanolamine-binding protein 0.0241 PF00690 Cation transporter/ATPase, N-terminus 0.0217 PF00122 E1-E2 ATPase 0.0123 PF00702 haloacid dehalogenase-like hydrolase 0.0059 PF00107 Zinc-binding dehydrogenase 0.0044 PF00664 ABC transporter transmembrane region 0.0024 PF00689 Cation transporting ATPase, C-terminus 0.0010 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0009 PF00248 Aldo/keto reductase family SUB809 SC1CC(S)CCC1 0.5000 PF02038 ATP1G1/PLM/MAT8 family 0.1457 PF02146 Sir2 family 0.0259 PF00194 Eukaryotic-type carbonic anhydrase SUB611 C-O-C-O-C 0.5000 PF00403 Heavy-metal-associated domain 0.3514 PF00884 Sulfatase 0.0188 PF00001 7 transmembrane receptor (rhodopsin family), 0.0154 PF04711 Apolipoprotein A-II (ApoA-II), SUB589 O=C-C-C=O 0.5000 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.4277 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.2599 PF00377 Prion/Doppel alpha-helical domain 0.0654 PF00405 Transferrin 0.0381 PF03098 Animal haem peroxidase SUB215 >= 1 saturated or aromatic carbon-only ring size 7 0.5000 PF00717 Peptidase S24-like 0.2906 PF00135 Carboxylesterase 0.0636 PF00520 Ion transport protein 0.0196 PF00001 7 transmembrane receptor (rhodopsin family), SUB333 C(~C)(~C) 0.5000 PF01227 GTP cyclohydrolase I 0.0867 PF00958 GMP synthase C terminal domain 0.0209 PF00337 Galactoside-binding lectin 0.0002 PF03171 2OG-Fe(II), oxygenase superfamily SUB52 >= 1 Al 0.5000 PF00273 Serum albumin family 0.4287 PF00405 Transferrin 0.3896 PF01459 Eukaryotic porin 0.3636 PF00702 haloacid dehalogenase-like hydrolase SUB762 Oc1c(O)cccc1 0.4995 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.2181 PF01596 O-methyltransferase 0.2022 PF00918 Gastrin/cholecystokinin family 0.0897 PF00001 7 transmembrane receptor (rhodopsin family), SUB340 C(~C)(~C)(~H)(~O) 0.4972 PF01433 Peptidase family M1 0.3870 PF07686 Immunoglobulin V-set domain 0.3626 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.3394 PF02898 Nitric oxide synthase, oxygenase domain 0.2717 PF00001 7 transmembrane receptor (rhodopsin family), 0.2200 PF00341 Platelet-derived growth factor (PDGF), 0.1501 PF01462 Leucine rich repeat N-terminal domain 0.1242 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.1228 PF00084 Sushi domain (SCR repeat), 0.1105 PF00175 Oxidoreductase NAD-binding domain 0.0854 PF00520 Ion transport protein 0.0670 PF00248 Aldo/keto reductase family 0.0430 PF00135 Carboxylesterase 0.0382 PF03062 MBOAT family 0.0351 PF00019 Transforming growth factor beta like domain 0.0316 PF00027 Cyclic nucleotide-binding domain 0.0295 PF00688 TGF-beta propeptide SUB334 C(~C)(~C)(~C) 0.4940 PF00248 Aldo/keto reductase family 0.2495 PF02770 Acyl-CoA dehydrogenase, middle domain 0.2088 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.2072 PF01063 Aminotransferase class IV 0.1541 PF00689 Cation transporting ATPase, C-terminus 0.1539 PF00690 Cation transporter/ATPase, N-terminus 0.1501 PF00441 Acyl-CoA dehydrogenase, C-terminal domain SUB23 >= 16 O 0.4927 PF00002 7 transmembrane receptor (Secretin family), 0.4729 PF01835 MG2 domain 0.4666 PF07703 Alpha-2-macroglobulin family N-terminal region 0.4534 PF02793 Hormone receptor domain 0.3365 PF00248 Aldo/keto reductase family 0.1978 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.1168 PF08702 Fibrinogen alpha/beta chain family 0.0915 PF00378 Enoyl-CoA hydratase/isomerase family 0.0843 PF00675 Insulinase (Peptidase family M16), 0.0055 PF00088 Trefoil (P-type), domain 0.0052 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0021 PF01055 Glycosyl hydrolases family 31 SUB718 Cc1ccc(Cl)cc1 0.4898 PF00168 C2 domain 0.3600 PF01094 Receptor family ligand binding region 0.1482 PF00032 Cytochrome b(C-terminal), /b6/petD 0.1014 PF00001 7 transmembrane receptor (rhodopsin family), 0.0030 PF00043 Glutathione S-transferase, C-terminal domain SUB60 >= 1 Co 0.4889 PF01122 Eukaryotic cobalamin-binding protein 0.2304 PF03308 ArgK protein 0.1346 PF01923 Cobalamin adenosyltransferase 0.0001 PF02310 B12 binding domain SUB249 >= 1 any ring size 10 0.4853 PF03493 Calcium-activated BK potassium channel alpha subunit 0.4389 PF02254 TrkA-N domain 0.2646 PF07690 Major Facilitator Superfamily 0.2554 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.2067 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.2017 PF00067 Cytochrome P450 0.1342 PF00204 DNA gyrase B 0.1108 PF08070 DTHCT (NUC029), region 0.1092 PF02219 Methylenetetrahydrofolate reductase 0.0881 PF00229 TNF(Tumour Necrosis Factor), family 0.0448 PF00069 Protein kinase domain 0.0363 PF00051 Kringle domain 0.0039 PF02161 Progesterone receptor SUB756 Cc1c(C)cccc1 0.4836 PF07645 Calcium-binding EGF domain 0.3962 PF11956 Ankyrin-G binding motif of KCNQ2-3 0.3387 PF00433 Protein kinase C terminal domain 0.3066 PF04756 OST3 / OST6 family 0.2512 PF01234 NNMT/PNMT/TEMT family 0.1340 PF00170 bZIP transcription factor 0.1277 PF00043 Glutathione S-transferase, C-terminal domain 0.1228 PF00643 B-box zinc finger 0.1120 PF02798 Glutathione S-transferase, N-terminal domain 0.0927 PF00209 Sodium:neurotransmitter symporter family 0.0870 PF03098 Animal haem peroxidase 0.0597 PF00040 Fibronectin type II domain 0.0393 PF00105 Zinc finger, C4 type (two domains), 0.0216 PF01593 Flavin containing amine oxidoreductase SUB261 >= 3 hetero-aromatic rings 0.4816 PF01434 Peptidase family M41 0.3457 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.3251 PF00005 ABC transporter 0.3219 PF00018 SH3 domain 0.2830 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.2270 PF00106 short chain dehydrogenase 0.1971 PF12062 heparan sulfate-N-deacetylase 0.1776 PF00023 Ankyrin repeat 0.1628 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.1118 PF00212 Atrial natriuretic peptide 0.1118 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.1068 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0989 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0979 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0936 PF08996 DNA Polymerase alpha zinc finger 0.0888 PF04716 ETC complex I subunit conserved region 0.0857 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0715 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0508 PF00017 SH2 domain 0.0462 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0174 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0114 PF00378 Enoyl-CoA hydratase/isomerase family 0.0072 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit SUB51 >= 1 Mg 0.4791 PF00625 Guanylate kinase 0.2568 PF00690 Cation transporter/ATPase, N-terminus 0.0709 PF08763 Voltage gated calcium channel IQ domain 0.0063 PF00702 haloacid dehalogenase-like hydrolase 0.0035 PF00689 Cation transporting ATPase, C-terminus 0.0031 PF00122 E1-E2 ATPase SUB730 Nc1ccc(Cl)cc1 0.4767 PF00343 Carbohydrate phosphorylase 0.2807 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1631 PF03073 TspO/MBR family 0.0597 PF07686 Immunoglobulin V-set domain 0.0171 PF02931 Neurotransmitter-gated ion-channel ligand binding domain SUB719 Cc1ccc(Br)cc1 0.4763 PF00432 Prenyltransferase and squalene oxidase repeat 0.0237 PF00641 Zn-finger in Ran binding protein and others SUB683 O-C-C-C-C-N 0.4761 PF07885 Ion channel 0.3499 PF00225 Kinesin motor domain 0.3437 PF01607 Chitin binding Peritrophin-A domain 0.3185 PF00266 Aminotransferase class-V 0.3146 PF01063 Aminotransferase class IV 0.3058 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.2963 PF02743 Cache domain 0.2824 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.2732 PF01055 Glycosyl hydrolases family 31 0.2111 PF00106 short chain dehydrogenase 0.2099 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.2034 PF00535 Glycosyl transferase family 2 0.1545 PF00153 Mitochondrial carrier protein 0.1461 PF02971 Formiminotransferase domain 0.1188 PF04961 Formiminotransferase-cyclodeaminase 0.1134 PF07654 Immunoglobulin C1-set domain 0.0897 PF00619 Caspase recruitment domain 0.0833 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0829 PF02310 B12 binding domain 0.0826 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0798 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0655 PF01571 Aminomethyltransferase folate-binding domain 0.0647 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0501 PF00171 Aldehyde dehydrogenase family 0.0460 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0420 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0364 PF00068 Phospholipase A2 0.0341 PF00069 Protein kinase domain 0.0304 PF00375 Sodium:dicarboxylate symporter family 0.0252 PF01030 Receptor L domain 0.0159 PF00023 Ankyrin repeat 0.0151 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0049 PF00088 Trefoil (P-type), domain 0.0019 PF00704 Glycosyl hydrolases family 18 0.0008 PF00757 Furin-like cysteine rich region 0.0001 PF08399 VWA N-terminal SUB736 Cc1cc(O)ccc1 0.4730 PF00001 7 transmembrane receptor (rhodopsin family), 0.2603 PF02159 Oestrogen receptor 0.2218 PF00225 Kinesin motor domain 0.1823 PF00643 B-box zinc finger 0.0937 PF00209 Sodium:neurotransmitter symporter family 0.0171 PF00884 Sulfatase SUB3 >= 16 H 0.4717 PF00005 ABC transporter 0.3592 PF00001 7 transmembrane receptor (rhodopsin family), 0.2650 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.2515 PF00169 PH domain 0.2321 PF00432 Prenyltransferase and squalene oxidase repeat 0.2277 PF08763 Voltage gated calcium channel IQ domain 0.2146 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.1855 PF00017 SH2 domain 0.1597 PF00067 Cytochrome P450 0.0825 PF00106 short chain dehydrogenase 0.0408 PF00664 ABC transporter transmembrane region 0.0136 PF00168 C2 domain 0.0044 PF00023 Ankyrin repeat 0.0037 PF00536 SAM domain (Sterile alpha motif), 0.0034 PF01404 Ephrin receptor ligand binding domain SUB815 NC1CC(Br)CCC1 0.4708 PF00001 7 transmembrane receptor (rhodopsin family), SUB287 C-O 0.4672 PF00145 C-5 cytosine-specific DNA methylase 0.1534 PF00194 Eukaryotic-type carbonic anhydrase 0.0204 PF00520 Ion transport protein SUB624 O=C-C:C-C 0.4670 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.4357 PF01347 Lipoprotein amino terminal region 0.2132 PF01467 Cytidylyltransferase 0.1547 PF00571 CBS domain 0.1422 PF00354 Pentaxin family 0.1115 PF00464 Serine hydroxymethyltransferase 0.0386 PF02971 Formiminotransferase domain 0.0293 PF00343 Carbohydrate phosphorylase 0.0217 PF00520 Ion transport protein 0.0069 PF00273 Serum albumin family 0.0002 PF08403 Amino acid permease N-terminal SUB545 O-C:C-O 0.4654 PF01596 O-methyltransferase 0.3091 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.2141 PF00918 Gastrin/cholecystokinin family SUB39 >= 2 Cl 0.4633 PF00067 Cytochrome P450 0.2456 PF00689 Cation transporting ATPase, C-terminus 0.2058 PF00702 haloacid dehalogenase-like hydrolase 0.1553 PF00690 Cation transporter/ATPase, N-terminus SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 0.4631 PF00211 Adenylate and Guanylate cyclase catalytic domain 0.2778 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.2415 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.2083 PF02173 pKID domain 0.1939 PF00170 bZIP transcription factor 0.1639 PF00571 CBS domain 0.1103 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0567 PF00069 Protein kinase domain 0.0070 PF02872 5"-nucleotidase, C-terminal domain SUB712 C-C(C)(C)-C-C 0.4622 PF00104 Ligand-binding domain of nuclear hormone receptor 0.3490 PF03953 Tubulin C-terminal domain 0.3228 PF00091 Tubulin/FtsZ family, GTPase domain 0.2409 PF00001 7 transmembrane receptor (rhodopsin family), 0.2212 PF00106 short chain dehydrogenase 0.1723 PF08035 Opioids neuropeptide 0.1708 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1311 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.1159 PF00520 Ion transport protein 0.1156 PF08384 Pro-opiomelanocortin, N-terminal region 0.0810 PF00653 Inhibitor of Apoptosis domain 0.0215 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0047 PF00497 Bacterial extracellular solute-binding proteins, family 3 SUB59 >= 1 Fe 0.4620 PF00061 Lipocalin / cytosolic fatty-acid binding protein family SUB286 C-N 0.4584 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0320 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus SUB801 CC1CC(N)CCC1 0.4578 PF02394 Interleukin-1 propeptide 0.4497 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.3071 PF01122 Eukaryotic cobalamin-binding protein 0.2915 PF01061 ABC-2 type transporter 0.1692 PF06327 Domain of Unknown Function (DUF1053), 0.1435 PF00340 Interleukin-1 / 18 0.1306 PF01923 Cobalamin adenosyltransferase 0.1003 PF02310 B12 binding domain 0.0766 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0721 PF01833 IPT/TIG domain 0.0570 PF00001 7 transmembrane receptor (rhodopsin family), 0.0367 PF00324 Amino acid permease 0.0141 PF02932 Neurotransmitter-gated ion-channel transmembrane region SUB615 C-C-O-C-C 0.4572 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.3774 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.1410 PF06512 Sodium ion transport-associated 0.0904 PF07654 Immunoglobulin C1-set domain 0.0898 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0816 PF00714 Interferon gamma 0.0761 PF00079 Serpin (serine protease inhibitor), 0.0716 PF00571 CBS domain 0.0496 PF00106 short chain dehydrogenase 0.0473 PF01401 Angiotensin-converting enzyme 0.0085 PF01841 Transglutaminase-like superfamily 0.0041 PF00927 Transglutaminase family, C-terminal ig like domain 0.0031 PF00757 Furin-like cysteine rich region 0.0025 PF00868 Transglutaminase family 0.0004 PF02931 Neurotransmitter-gated ion-channel ligand binding domain SUB349 C(~C)(~H)(~P) 0.4538 PF12179 I-kappa-kinase-beta NEMO binding domain 0.3978 PF00328 Histidine acid phosphatase SUB578 C:C-N-C:C 0.4537 PF07686 Immunoglobulin V-set domain 0.4295 PF00343 Carbohydrate phosphorylase 0.4116 PF00043 Glutathione S-transferase, C-terminal domain 0.3261 PF00858 Amiloride-sensitive sodium channel 0.1290 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.1159 PF00291 Pyridoxal-phosphate dependent enzyme 0.0240 PF07690 Major Facilitator Superfamily 0.0133 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB581 O=C-C-C-N 0.4531 PF01731 Arylesterase 0.3154 PF01593 Flavin containing amine oxidoreductase 0.2145 PF06512 Sodium ion transport-associated 0.1924 PF01336 OB-fold nucleic acid binding domain 0.0933 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0274 PF00153 Mitochondrial carrier protein 0.0198 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0037 PF00536 SAM domain (Sterile alpha motif), 0.0003 PF02932 Neurotransmitter-gated ion-channel transmembrane region SUB580 O=C-C-C-C 0.4526 PF00153 Mitochondrial carrier protein 0.4353 PF00106 short chain dehydrogenase 0.3813 PF03807 NADP oxidoreductase coenzyme F420-dependent 0.2230 PF02574 Homocysteine S-methyltransferase 0.2183 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.1715 PF03372 Endonuclease/Exonuclease/phosphatase family 0.1673 PF02798 Glutathione S-transferase, N-terminal domain 0.1581 PF00069 Protein kinase domain 0.1243 PF01023 S-100/ICaBP type calcium binding domain 0.1128 PF00067 Cytochrome P450 0.0893 PF03171 2OG-Fe(II), oxygenase superfamily 0.0605 PF00202 Aminotransferase class-III 0.0291 PF00413 Matrixin 0.0256 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0169 PF01061 ABC-2 type transporter 0.0153 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0005 PF07706 Aminotransferase ubiquitination site SUB207 >= 5 any ring size 6 0.4508 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.4308 PF02931 Neurotransmitter-gated ion-channel ligand binding domain SUB792 NC1CCC(N)CC1 0.4507 PF00001 7 transmembrane receptor (rhodopsin family), 0.1893 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase SUB421 C=O 0.4506 PF00107 Zinc-binding dehydrogenase 0.2758 PF00001 7 transmembrane receptor (rhodopsin family), 0.2529 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.1948 PF00202 Aminotransferase class-III 0.0584 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0313 PF00248 Aldo/keto reductase family 0.0297 PF08240 Alcohol dehydrogenase GroES-like domain 0.0040 PF02166 Androgen receptor 0.0021 PF00051 Kringle domain 0.0017 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0011 PF02347 Glycine cleavage system P-protein 0.0009 PF01212 Beta-eliminating lyase SUB458 S(-C)(=O) 0.4503 PF00230 Major intrinsic protein 0.2472 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.1464 PF01007 Inward rectifier potassium channel 0.0277 PF00186 Dihydrofolate reductase 0.0119 PF03098 Animal haem peroxidase 0.0003 PF01590 GAF domain 0.0003 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SUB782 CC1CCC(Br)CC1 0.4502 PF00432 Prenyltransferase and squalene oxidase repeat SUB160 >= 3 saturated or aromatic nitrogen-containing ring size 5 0.4497 PF03002 Somatostatin/Cortistatin family 0.1566 PF00209 Sodium:neurotransmitter symporter family 0.0637 PF04679 ATP dependent DNA ligase C terminal region SUB456 N(-O)(=O) 0.4474 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0012 PF02166 Androgen receptor 0.0002 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily SUB299 C-I 0.4473 PF12605 Casein kinase 1 gamma C terminal 0.2625 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0023 PF00079 Serpin (serine protease inhibitor), SUB313 O-Al 0.4438 PF01459 Eukaryotic porin SUB189 >= 2 saturated or aromatic heteroatom-containing ring size 6 0.4432 PF02259 FAT domain 0.1610 PF00001 7 transmembrane receptor (rhodopsin family), 0.0553 PF00689 Cation transporting ATPase, C-terminus 0.0509 PF00122 E1-E2 ATPase 0.0448 PF00690 Cation transporter/ATPase, N-terminus 0.0003 PF02260 FATC domain SUB459 S(-O)(=O) 0.4430 PF01530 Zinc finger, C2HC type 0.3773 PF00822 PMP-22/EMP/MP20/Claudin family 0.2197 PF00089 Trypsin 0.1429 PF03098 Animal haem peroxidase 0.0688 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0560 PF07885 Ion channel 0.0497 PF00230 Major intrinsic protein 0.0171 PF00520 Ion transport protein SUB186 >= 2 any ring size 6 0.4406 PF00067 Cytochrome P450 0.2352 PF01007 Inward rectifier potassium channel 0.1793 PF03098 Animal haem peroxidase 0.1234 PF00204 DNA gyrase B 0.1108 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0935 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0583 PF00069 Protein kinase domain 0.0504 PF00106 short chain dehydrogenase 0.0342 PF08070 DTHCT (NUC029), region SUB825 OC1C(O)CCCC1 0.4395 PF01596 O-methyltransferase 0.3294 PF03953 Tubulin C-terminal domain 0.3127 PF00091 Tubulin/FtsZ family, GTPase domain 0.2442 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.2323 PF00664 ABC transporter transmembrane region 0.0895 PF00001 7 transmembrane receptor (rhodopsin family), 0.0002 PF02931 Neurotransmitter-gated ion-channel ligand binding domain SUB31 >= 1 P 0.4384 PF03770 Inositol polyphosphate kinase 0.2389 PF02441 Flavoprotein 0.1122 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0889 PF00074 Pancreatic ribonuclease 0.0864 PF00017 SH2 domain 0.0660 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 0.0399 PF01130 CD36 family 0.0339 PF00316 Fructose-1-6-bisphosphatase 0.0336 PF00929 Exonuclease 0.0327 PF02666 Phosphatidylserine decarboxylase 0.0217 PF00692 dUTPase 0.0213 PF01033 Somatomedin B domain 0.0163 PF11404 Potassium voltage-gated channel 0.0143 PF02214 K+ channel tetramerisation domain 0.0057 PF01852 START domain 0.0010 PF00018 SH3 domain SUB779 CC1CCC(S)CC1 0.4384 PF00005 ABC transporter 0.0394 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0230 PF00105 Zinc finger, C4 type (two domains), SUB295 C-Cl 0.4380 PF02888 Calmodulin binding domain 0.1749 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1045 PF00043 Glutathione S-transferase, C-terminal domain 0.0908 PF02254 TrkA-N domain 0.0398 PF03073 TspO/MBR family 0.0201 PF00690 Cation transporter/ATPase, N-terminus 0.0005 PF03530 Calcium-activated SK potassium channel 0.0002 PF00001 7 transmembrane receptor (rhodopsin family), SUB486 N:C:C:N 0.4365 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.4020 PF00858 Amiloride-sensitive sodium channel 0.3478 PF04389 Peptidase family M28 0.1986 PF00520 Ion transport protein 0.1950 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.1929 PF01923 Cobalamin adenosyltransferase 0.1804 PF00821 Phosphoenolpyruvate carboxykinase 0.1515 PF00221 Phenylalanine and histidine ammonia-lyase 0.1474 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1107 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1099 PF00153 Mitochondrial carrier protein 0.1093 PF05995 Cysteine dioxygenase type I 0.1054 PF04800 ETC complex I subunit conserved region 0.0673 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0513 PF00962 Adenosine/AMP deaminase 0.0391 PF00067 Cytochrome P450 0.0200 PF00156 Phosphoribosyl transferase domain 0.0060 PF00233 3"5"-cyclic nucleotide phosphodiesterase SUB793 NC1CCC(Cl)CC1 0.4364 PF00343 Carbohydrate phosphorylase 0.1075 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0969 PF07686 Immunoglobulin V-set domain 0.0719 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0001 PF03073 TspO/MBR family SUB550 N-C-C:C 0.4354 PF00229 TNF(Tumour Necrosis Factor), family 0.1517 PF00089 Trypsin 0.0632 PF01234 NNMT/PNMT/TEMT family SUB256 >= 1 aromatic ring 0.4350 PF00001 7 transmembrane receptor (rhodopsin family), 0.1199 PF00478 IMP dehydrogenase / GMP reductase domain 0.0294 PF00233 3"5"-cyclic nucleotide phosphodiesterase SUB711 C-C-C(C)-C-C 0.4348 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.1936 PF00520 Ion transport protein 0.0634 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0617 PF00229 TNF(Tumour Necrosis Factor), family SUB406 O(~C)(~C) 0.4321 PF00122 E1-E2 ATPase 0.4029 PF00001 7 transmembrane receptor (rhodopsin family), 0.2479 PF00337 Galactoside-binding lectin 0.2130 PF00059 Lectin C-type domain 0.2091 PF07645 Calcium-binding EGF domain 0.1625 PF00135 Carboxylesterase 0.0677 PF00057 Low-density lipoprotein receptor domain class A 0.0655 PF00168 C2 domain 0.0404 PF00146 NADH dehydrogenase SUB602 N-C:C:C-N 0.4312 PF00069 Protein kinase domain 0.2955 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.2760 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.2085 PF00041 Fibronectin type III domain 0.1050 PF00023 Ankyrin repeat 0.1020 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0991 PF12062 heparan sulfate-N-deacetylase 0.0913 PF02817 e3 binding domain 0.0783 PF00017 SH2 domain 0.0541 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0506 PF00106 short chain dehydrogenase 0.0420 PF02865 STAT protein, protein interaction domain 0.0325 PF00300 Phosphoglycerate mutase family 0.0311 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0075 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0063 PF01591 6-phosphofructo-2-kinase 0.0019 PF01017 STAT protein, all-alpha domain SUB751 Nc1cc(Cl)ccc1 0.4309 PF00043 Glutathione S-transferase, C-terminal domain 0.2286 PF00168 C2 domain 0.0843 PF00209 Sodium:neurotransmitter symporter family 0.0162 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0125 PF02254 TrkA-N domain SUB862 CC1C(O)CCC1 0.4301 PF00001 7 transmembrane receptor (rhodopsin family), 0.1979 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.1498 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0967 PF08377 MAP2/Tau projection domain SUB547 N-C:C-[#1] 0.4297 PF07885 Ion channel 0.0202 PF00091 Tubulin/FtsZ family, GTPase domain 0.0182 PF03953 Tubulin C-terminal domain 0.0011 PF00001 7 transmembrane receptor (rhodopsin family), SUB447 C(-H)(=C) 0.4265 PF03098 Animal haem peroxidase 0.0193 PF00067 Cytochrome P450 SUB368 C(~H)(~O)(~O) 0.4227 PF00090 Thrombospondin type 1 domain 0.2566 PF00041 Fibronectin type III domain 0.1900 PF07686 Immunoglobulin V-set domain 0.1780 PF01869 BadF/BadG/BcrA/BcrD ATPase family 0.1750 PF00167 Fibroblast growth factor 0.1685 PF00293 NUDIX domain 0.1631 PF00236 Glycoprotein hormone 0.1559 PF00079 Serpin (serine protease inhibitor), 0.0464 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 0.0201 PF07645 Calcium-binding EGF domain 0.0152 PF00089 Trypsin SUB614 C-N-C-C-C 0.4225 PF01007 Inward rectifier potassium channel 0.0910 PF00135 Carboxylesterase 0.0653 PF00520 Ion transport protein 0.0527 PF00755 Choline/Carnitine o-acyltransferase 0.0020 PF00001 7 transmembrane receptor (rhodopsin family), SUB275 B-C 0.4201 PF00227 Proteasome subunit SUB781 CC1CCC(Cl)CC1 0.4169 PF01094 Receptor family ligand binding region 0.3017 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0501 PF00032 Cytochrome b(C-terminal), /b6/petD SUB813 NC1CC(N)CCC1 0.4144 PF00754 F5/8 type C domain 0.1871 PF00005 ABC transporter 0.0563 PF00091 Tubulin/FtsZ family, GTPase domain 0.0532 PF03953 Tubulin C-terminal domain 0.0039 PF00405 Transferrin SUB352 C(~C)(~N) 0.4137 PF00001 7 transmembrane receptor (rhodopsin family), SUB690 O-C-C-C-C-C-C 0.4126 PF08763 Voltage gated calcium channel IQ domain 0.1614 PF01094 Receptor family ligand binding region 0.1328 PF00413 Matrixin 0.1288 PF01279 Parathyroid hormone family 0.0648 PF07706 Aminotransferase ubiquitination site 0.0479 PF00520 Ion transport protein 0.0209 PF10420 Cytokine interleukin-12p40 C-terminus 0.0202 PF00089 Trypsin 0.0097 PF01151 GNS1/SUR4 family SUB35 >= 2 S 0.4125 PF04055 Radical SAM superfamily 0.3270 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.2981 PF00001 7 transmembrane receptor (rhodopsin family), 0.2023 PF00778 DIX domain 0.0764 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0400 PF08833 Axin beta-catenin binding domain 0.0327 PF00324 Amino acid permease 0.0186 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0128 PF00079 Serpin (serine protease inhibitor), 0.0029 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0015 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain SUB440 C(-C)(-N)(=O) 0.4114 PF00068 Phospholipase A2 0.3689 PF03073 TspO/MBR family 0.3209 PF00079 Serpin (serine protease inhibitor), 0.2838 PF00337 Galactoside-binding lectin 0.2818 PF00868 Transglutaminase family 0.2790 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.2772 PF00927 Transglutaminase family, C-terminal ig like domain 0.2420 PF01007 Inward rectifier potassium channel 0.2229 PF01841 Transglutaminase-like superfamily 0.1921 PF01471 Putative peptidoglycan binding domain 0.1426 PF00045 Hemopexin 0.0871 PF00105 Zinc finger, C4 type (two domains), 0.0697 PF00622 SPRY domain 0.0492 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0260 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0113 PF00533 BRCA1 C Terminus (BRCT), domain SUB451 C(-N)(=N) 0.4094 PF00069 Protein kinase domain 0.3671 PF00001 7 transmembrane receptor (rhodopsin family), 0.1498 PF01048 Phosphorylase superfamily 0.1206 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0995 PF00089 Trypsin SUB568 O-C-C-O 0.4092 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.2884 PF00017 SH2 domain 0.1706 PF00018 SH3 domain 0.1015 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0864 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain SUB677 N#C-C-C-C 0.4089 PF00520 Ion transport protein 0.3863 PF00194 Eukaryotic-type carbonic anhydrase 0.2012 PF00001 7 transmembrane receptor (rhodopsin family), 0.1041 PF00105 Zinc finger, C4 type (two domains), 0.0790 PF00104 Ligand-binding domain of nuclear hormone receptor SUB666 N-C:C-C-C 0.4055 PF00520 Ion transport protein 0.0406 PF00273 Serum albumin family 0.0038 PF06512 Sodium ion transport-associated SUB663 O-C-C-O-C 0.3984 PF00089 Trypsin 0.3634 PF00454 Phosphatidylinositol 3- and 4-kinase 0.2272 PF00135 Carboxylesterase 0.2193 PF00176 SNF2 family N-terminal domain 0.0975 PF03727 Hexokinase 0.0583 PF00041 Fibronectin type III domain 0.0544 PF00349 Hexokinase 0.0297 PF00001 7 transmembrane receptor (rhodopsin family), 0.0284 PF00625 Guanylate kinase SUB144 >= 1 any ring size 5 0.3980 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.3148 PF02166 Androgen receptor 0.2538 PF00554 Rel homology domain (RHD), 0.2397 PF00079 Serpin (serine protease inhibitor), 0.2078 PF00067 Cytochrome P450 0.1818 PF03171 2OG-Fe(II), oxygenase superfamily 0.1645 PF02159 Oestrogen receptor 0.1508 PF00689 Cation transporting ATPase, C-terminus 0.1057 PF00690 Cation transporter/ATPase, N-terminus 0.0531 PF00001 7 transmembrane receptor (rhodopsin family), 0.0442 PF00069 Protein kinase domain 0.0180 PF00209 Sodium:neurotransmitter symporter family SUB332 C(~Br)(:N) 0.3978 PF03002 Somatostatin/Cortistatin family SUB196 >= 3 saturated or aromatic heteroatom-containing ring size 6 0.3967 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0034 PF01068 ATP dependent DNA ligase domain 0.0031 PF01055 Glycosyl hydrolases family 31 SUB376 C(~N)(~N) 0.3952 PF01007 Inward rectifier potassium channel 0.3007 PF00171 Aldehyde dehydrogenase family 0.2050 PF00531 Death domain 0.1903 PF00051 Kringle domain 0.1489 PF00317 Ribonucleotide reductase, all-alpha domain 0.0955 PF03477 ATP cone domain 0.0813 PF02867 Ribonucleotide reductase, barrel domain 0.0474 PF00303 Thymidylate synthase SUB662 O-C-O-C-C 0.3936 PF00209 Sodium:neurotransmitter symporter family 0.2739 PF00860 Permease family 0.2657 PF00021 u-PAR/Ly-6 domain 0.1436 PF01094 Receptor family ligand binding region 0.1196 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0771 PF00041 Fibronectin type III domain 0.0360 PF07654 Immunoglobulin C1-set domain 0.0219 PF03171 2OG-Fe(II), oxygenase superfamily 0.0072 PF00067 Cytochrome P450 0.0045 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0040 PF04711 Apolipoprotein A-II (ApoA-II), SUB130 >= 1 any ring size 4 0.3924 PF00854 POT family 0.1282 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0984 PF02460 Patched family SUB345 C(~C)(~H) 0.3891 PF00045 Hemopexin 0.3407 PF00060 Ligand-gated ion channel 0.2038 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1984 PF00273 Serum albumin family 0.1950 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1448 PF09127 Leukotriene A4 hydrolase, C-terminal 0.0869 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0276 PF00102 Protein-tyrosine phosphatase SUB95 >= 1 Au 0.3882 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0002 PF00069 Protein kinase domain SUB638 O-C-C-C-C 0.3871 PF00764 Arginosuccinate synthase 0.3652 PF00001 7 transmembrane receptor (rhodopsin family), 0.2706 PF00153 Mitochondrial carrier protein 0.1577 PF00068 Phospholipase A2 0.1057 PF00175 Oxidoreductase NAD-binding domain 0.0899 PF02574 Homocysteine S-methyltransferase 0.0602 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0081 PF07706 Aminotransferase ubiquitination site SUB543 O-C:C-[#1] 0.3870 PF00656 Caspase domain 0.1924 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.1373 PF01462 Leucine rich repeat N-terminal domain 0.0666 PF00001 7 transmembrane receptor (rhodopsin family), 0.0427 PF00005 ABC transporter SUB21 >= 4 O 0.3868 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.3389 PF00413 Matrixin 0.2945 PF00106 short chain dehydrogenase 0.2827 PF01590 GAF domain 0.2530 PF07562 Nine Cysteines Domain of family 3 GPCR 0.2527 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.2454 PF00822 PMP-22/EMP/MP20/Claudin family 0.2394 PF00354 Pentaxin family 0.2225 PF00531 Death domain 0.1941 PF03949 Malic enzyme, NAD binding domain 0.1626 PF01094 Receptor family ligand binding region 0.1194 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.1100 PF00153 Mitochondrial carrier protein 0.1024 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0551 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0089 PF00001 7 transmembrane receptor (rhodopsin family), 0.0040 PF00089 Trypsin 0.0001 PF00390 Malic enzyme, N-terminal domain SUB806 OC1CC(N)CCC1 0.3868 PF00341 Platelet-derived growth factor (PDGF), 0.2210 PF00029 Connexin 0.2123 PF10582 Gap junction channel protein cysteine-rich domain 0.0984 PF05790 Immunoglobulin C2-set domain 0.0964 PF00123 Peptide hormone 0.0538 PF00069 Protein kinase domain 0.0488 PF03508 Gap junction alpha-1 protein (Cx43), SUB228 >= 1 any ring size 8 0.3859 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.2096 PF03098 Animal haem peroxidase 0.1864 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1582 PF00918 Gastrin/cholecystokinin family 0.0542 PF00341 Platelet-derived growth factor (PDGF), SUB12 >= 8 C 0.3854 PF01593 Flavin containing amine oxidoreductase 0.2305 PF06512 Sodium ion transport-associated 0.2088 PF00702 haloacid dehalogenase-like hydrolase 0.1399 PF01477 PLAT/LH2 domain 0.1092 PF00001 7 transmembrane receptor (rhodopsin family), 0.0427 PF00067 Cytochrome P450 0.0129 PF00501 AMP-binding enzyme SUB639 O-C-C-C-N 0.3850 PF00040 Fibronectin type II domain 0.2594 PF00088 Trefoil (P-type), domain 0.2103 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.1755 PF01055 Glycosyl hydrolases family 31 0.1441 PF01712 Deoxynucleoside kinase 0.1227 PF00989 PAS fold 0.0757 PF04952 Succinylglutamate desuccinylase / Aspartoacylase family 0.0696 PF02180 Bcl-2 homology region 4 0.0462 PF00709 Adenylosuccinate synthetase 0.0449 PF00202 Aminotransferase class-III 0.0448 PF00535 Glycosyl transferase family 2 0.0228 PF00001 7 transmembrane receptor (rhodopsin family), SUB45 >= 2 Br 0.3848 PF00568 WH1 domain 0.0614 PF02201 SWIB/MDM2 domain SUB151 >= 2 any ring size 5 0.3844 PF00069 Protein kinase domain 0.3705 PF00170 bZIP transcription factor 0.2442 PF11555 EGFR receptor inhibitor Mig-6 0.1501 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.1466 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1366 PF08040 MNLL subunit 0.1195 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0784 PF09027 GTPase binding 0.0781 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0312 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0029 PF01048 Phosphorylase superfamily SUB697 C-C-C-C-C-C-C-C 0.3830 PF00432 Prenyltransferase and squalene oxidase repeat 0.3637 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.2619 PF01007 Inward rectifier potassium channel 0.2124 PF00209 Sodium:neurotransmitter symporter family 0.1814 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.1369 PF03765 CRAL/TRIO, N-terminus 0.1192 PF00023 Ankyrin repeat 0.1021 PF01593 Flavin containing amine oxidoreductase 0.0987 PF00001 7 transmembrane receptor (rhodopsin family), 0.0975 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0853 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0736 PF08399 VWA N-terminal 0.0586 PF00650 CRAL/TRIO domain 0.0512 PF00079 Serpin (serine protease inhibitor), 0.0392 PF00092 von Willebrand factor type A domain 0.0249 PF00102 Protein-tyrosine phosphatase 0.0186 PF00579 tRNA synthetases class I (W and Y), 0.0002 PF02743 Cache domain SUB494 O=C-C:C 0.3815 PF00071 Ras family 0.3406 PF00017 SH2 domain 0.2167 PF00354 Pentaxin family 0.1460 PF00001 7 transmembrane receptor (rhodopsin family), 0.0883 PF00102 Protein-tyrosine phosphatase 0.0617 PF00105 Zinc finger, C4 type (two domains), 0.0510 PF00478 IMP dehydrogenase / GMP reductase domain 0.0003 PF08403 Amino acid permease N-terminal SUB645 C-C=N-N-C 0.3800 PF00233 3"5"-cyclic nucleotide phosphodiesterase SUB412 P(~O)(~O) 0.3795 PF00074 Pancreatic ribonuclease 0.3596 PF01652 Eukaryotic initiation factor 4E 0.1275 PF02441 Flavoprotein 0.1046 PF00248 Aldo/keto reductase family 0.1006 PF03770 Inositol polyphosphate kinase 0.0865 PF00017 SH2 domain 0.0848 PF00316 Fructose-1-6-bisphosphatase 0.0691 PF00018 SH3 domain 0.0291 PF00146 NADH dehydrogenase 0.0268 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0250 PF02214 K+ channel tetramerisation domain 0.0250 PF02666 Phosphatidylserine decarboxylase 0.0185 PF00692 dUTPase 0.0001 PF11404 Potassium voltage-gated channel SUB672 O=C-C=C-C 0.3785 PF00069 Protein kinase domain 0.1756 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1702 PF00337 Galactoside-binding lectin 0.1432 PF00305 Lipoxygenase 0.0875 PF00005 ABC transporter 0.0169 PF00273 Serum albumin family SUB378 C(~N)(:C)(:C) 0.3746 PF00229 TNF(Tumour Necrosis Factor), family 0.3391 PF00850 Histone deacetylase domain 0.2122 PF00005 ABC transporter 0.1709 PF01404 Ephrin receptor ligand binding domain 0.1614 PF00067 Cytochrome P450 0.1485 PF00536 SAM domain (Sterile alpha motif), 0.0892 PF00171 Aldehyde dehydrogenase family 0.0852 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0658 PF00092 von Willebrand factor type A domain 0.0076 PF00305 Lipoxygenase 0.0003 PF00822 PMP-22/EMP/MP20/Claudin family SUB648 O=C-N-C-N 0.3743 PF00692 dUTPase 0.2980 PF09303 KCNMB2, ball and chain domain 0.1155 PF00001 7 transmembrane receptor (rhodopsin family), 0.0901 PF03185 Calcium-activated potassium channel, beta subunit 0.0388 PF00343 Carbohydrate phosphorylase 0.0360 PF03360 Glycosyltransferase family 43 SUB769 Sc1c(Cl)cccc1 0.3742 PF02060 Slow voltage-gated potassium channel SUB802 CC1CC(Cl)CCC1 0.3740 PF00243 Nerve growth factor family 0.0637 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0043 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0018 PF00989 PAS fold SUB522 C:N-C-[#1] 0.3738 PF01731 Arylesterase 0.3003 PF00105 Zinc finger, C4 type (two domains), 0.2383 PF00017 SH2 domain 0.1049 PF00067 Cytochrome P450 0.0789 PF00069 Protein kinase domain 0.0782 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0548 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0514 PF00794 PI3-kinase family, ras-binding domain 0.0406 PF00792 Phosphoinositide 3-kinase C2 SUB353 C(~C)(~O) 0.3718 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.2742 PF00194 Eukaryotic-type carbonic anhydrase 0.1411 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.1362 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1258 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1229 PF00067 Cytochrome P450 0.1197 PF00209 Sodium:neurotransmitter symporter family 0.1008 PF00060 Ligand-gated ion channel 0.0437 PF00520 Ion transport protein SUB343 C(~C)(~Cl) 0.3716 PF00084 Sushi domain (SCR repeat), 0.2462 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0623 PF03530 Calcium-activated SK potassium channel 0.0437 PF02254 TrkA-N domain 0.0001 PF00689 Cation transporting ATPase, C-terminus SUB25 >= 2 F 0.3712 PF00702 haloacid dehalogenase-like hydrolase 0.3636 PF00689 Cation transporting ATPase, C-terminus 0.3521 PF00146 NADH dehydrogenase 0.2045 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.1712 PF00520 Ion transport protein 0.1240 PF00001 7 transmembrane receptor (rhodopsin family), 0.0545 PF02166 Androgen receptor 0.0181 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0010 PF00690 Cation transporter/ATPase, N-terminus SUB647 O=C-N-C-[#1] 0.3686 PF01401 Angiotensin-converting enzyme 0.3519 PF07686 Immunoglobulin V-set domain 0.3348 PF00656 Caspase domain 0.2939 PF01431 Peptidase family M13 0.2152 PF00357 Integrin alpha cytoplasmic region 0.2122 PF05649 Peptidase family M13 0.1760 PF00551 Formyl transferase 0.1688 PF00089 Trypsin 0.1460 PF00303 Thymidylate synthase 0.1268 PF01433 Peptidase family M1 0.1085 PF00026 Eukaryotic aspartyl protease 0.0404 PF01007 Inward rectifier potassium channel 0.0343 PF00115 Cytochrome C and Quinol oxidase polypeptide I 0.0266 PF00653 Inhibitor of Apoptosis domain 0.0203 PF00005 ABC transporter 0.0182 PF01477 PLAT/LH2 domain 0.0090 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0002 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase SUB646 O=C-N-C-C 0.3647 PF00074 Pancreatic ribonuclease 0.3520 PF00005 ABC transporter 0.2718 PF07686 Immunoglobulin V-set domain 0.2314 PF01180 Dihydroorotate dehydrogenase 0.2035 PF01477 PLAT/LH2 domain 0.1678 PF00343 Carbohydrate phosphorylase 0.1368 PF00017 SH2 domain 0.1118 PF00026 Eukaryotic aspartyl protease 0.1035 PF03068 Protein-arginine deiminase (PAD), 0.0690 PF00079 Serpin (serine protease inhibitor), 0.0638 PF08526 Protein-arginine deiminase (PAD), N-terminal domain 0.0585 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0514 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0343 PF00115 Cytochrome C and Quinol oxidase polypeptide I 0.0335 PF00105 Zinc finger, C4 type (two domains), 0.0234 PF08527 Protein-arginine deiminase (PAD), middle domain 0.0226 PF00001 7 transmembrane receptor (rhodopsin family), 0.0011 PF00104 Ligand-binding domain of nuclear hormone receptor SUB675 N-C-N-C:C 0.3643 PF00001 7 transmembrane receptor (rhodopsin family), 0.2848 PF00520 Ion transport protein 0.2452 PF00702 haloacid dehalogenase-like hydrolase 0.1136 PF02196 Raf-like Ras-binding domain 0.0946 PF00108 Thiolase, N-terminal domain 0.0836 PF00069 Protein kinase domain SUB621 C:C-O-C-C 0.3631 PF00591 Glycosyl transferase family, a/b domain 0.3619 PF01023 S-100/ICaBP type calcium binding domain 0.3382 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.2961 PF01030 Receptor L domain 0.2740 PF00989 PAS fold 0.2276 PF00105 Zinc finger, C4 type (two domains), 0.2006 PF00650 CRAL/TRIO domain 0.2005 PF00102 Protein-tyrosine phosphatase 0.1191 PF00079 Serpin (serine protease inhibitor), 0.0573 PF00001 7 transmembrane receptor (rhodopsin family), 0.0223 PF00149 Calcineurin-like phosphoesterase 0.0218 PF08441 Integrin alpha 0.0119 PF00561 alpha/beta hydrolase fold 0.0064 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0057 PF00757 Furin-like cysteine rich region 0.0049 PF00248 Aldo/keto reductase family SUB375 C(~H)(~H)(~H) 0.3616 PF00135 Carboxylesterase 0.2977 PF00258 Flavodoxin 0.2666 PF03781 Formylglycine-generating sulfatase enzyme 0.2397 PF00305 Lipoxygenase 0.2357 PF00667 FAD binding domain 0.2307 PF06512 Sodium ion transport-associated 0.2278 PF06628 Catalase-related immune-responsive 0.2187 PF03160 Calx-beta domain 0.2056 PF00041 Fibronectin type III domain 0.1885 PF01477 PLAT/LH2 domain 0.1779 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.1699 PF00001 7 transmembrane receptor (rhodopsin family), 0.1651 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.1270 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.1207 PF01180 Dihydroorotate dehydrogenase 0.1186 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1026 PF00122 E1-E2 ATPase 0.0968 PF00557 Metallopeptidase family M24 0.0960 PF00489 Interleukin-6/G-CSF/MGF family 0.0922 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0870 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0796 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0780 PF00149 Calcineurin-like phosphoesterase 0.0675 PF00105 Zinc finger, C4 type (two domains), 0.0610 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0447 PF00702 haloacid dehalogenase-like hydrolase 0.0440 PF00690 Cation transporter/ATPase, N-terminus 0.0396 PF00045 Hemopexin 0.0349 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0340 PF01411 tRNA synthetases class II (A), 0.0300 PF01471 Putative peptidoglycan binding domain 0.0205 PF00689 Cation transporting ATPase, C-terminus 0.0177 PF00168 C2 domain 0.0176 PF00787 PX domain 0.0152 PF00354 Pentaxin family 0.0103 PF07645 Calcium-binding EGF domain SUB632 O-C:C-O-[#1] 0.3610 PF01596 O-methyltransferase 0.1894 PF00069 Protein kinase domain 0.0608 PF00918 Gastrin/cholecystokinin family 0.0518 PF00001 7 transmembrane receptor (rhodopsin family), SUB500 N-C:C:N 0.3594 PF00962 Adenosine/AMP deaminase 0.1936 PF00221 Phenylalanine and histidine ammonia-lyase 0.1565 PF04389 Peptidase family M28 0.1239 PF05995 Cysteine dioxygenase type I 0.1122 PF01590 GAF domain 0.0994 PF00156 Phosphoribosyl transferase domain 0.0850 PF01923 Cobalamin adenosyltransferase 0.0433 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0376 PF00153 Mitochondrial carrier protein 0.0290 PF00501 AMP-binding enzyme 0.0222 PF01591 6-phosphofructo-2-kinase 0.0023 PF00794 PI3-kinase family, ras-binding domain 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), SUB296 C-As 0.3575 PF01161 Phosphatidylethanolamine-binding protein 0.3107 PF00105 Zinc finger, C4 type (two domains), 0.1794 PF00248 Aldo/keto reductase family 0.0110 PF00041 Fibronectin type III domain 0.0010 PF08240 Alcohol dehydrogenase GroES-like domain 0.0006 PF00107 Zinc-binding dehydrogenase SUB835 NC1C(Cl)CCCC1 0.3549 PF00001 7 transmembrane receptor (rhodopsin family), 0.0006 PF01404 Ephrin receptor ligand binding domain SUB180 >= 1 saturated or aromatic carbon-only ring size 6 0.3537 PF00001 7 transmembrane receptor (rhodopsin family), 0.2857 PF00209 Sodium:neurotransmitter symporter family 0.0224 PF00690 Cation transporter/ATPase, N-terminus 0.0217 PF00689 Cation transporting ATPase, C-terminus SUB351 C(~C)(~I) 0.3536 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0001 PF00079 Serpin (serine protease inhibitor), SUB495 O=C-C:N 0.3487 PF01652 Eukaryotic initiation factor 4E 0.2344 PF00821 Phosphoenolpyruvate carboxykinase 0.2278 PF00149 Calcineurin-like phosphoesterase 0.1331 PF03024 Folate receptor family 0.0610 PF07690 Major Facilitator Superfamily 0.0418 PF00927 Transglutaminase family, C-terminal ig like domain 0.0096 PF00071 Ras family 0.0001 PF01841 Transglutaminase-like superfamily 0.0001 PF00868 Transglutaminase family SUB394 N(~C)(~H) 0.3485 PF00186 Dihydrofolate reductase 0.3231 PF02727 Copper amine oxidase, N2 domain 0.3132 PF01179 Copper amine oxidase, enzyme domain 0.2750 PF02008 CXXC zinc finger domain 0.2554 PF02728 Copper amine oxidase, N3 domain 0.2546 PF00051 Kringle domain 0.2409 PF00209 Sodium:neurotransmitter symporter family 0.1787 PF01593 Flavin containing amine oxidoreductase 0.1686 PF00001 7 transmembrane receptor (rhodopsin family), 0.0128 PF00092 von Willebrand factor type A domain SUB517 [#1]-C=C-[#1] 0.3473 PF00069 Protein kinase domain 0.1838 PF03098 Animal haem peroxidase 0.1614 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.1232 PF03949 Malic enzyme, NAD binding domain 0.0962 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0914 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0886 PF00023 Ankyrin repeat 0.0599 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0476 PF00390 Malic enzyme, N-terminal domain 0.0434 PF00413 Matrixin 0.0405 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0263 PF00018 SH3 domain 0.0256 PF00107 Zinc-binding dehydrogenase SUB560 O-C-N-[#1] 0.3444 PF00377 Prion/Doppel alpha-helical domain 0.1751 PF00001 7 transmembrane receptor (rhodopsin family), 0.1689 PF04679 ATP dependent DNA ligase C terminal region 0.1575 PF03002 Somatostatin/Cortistatin family 0.0183 PF01068 ATP dependent DNA ligase domain SUB659 C-C-S-C-C 0.3440 PF00001 7 transmembrane receptor (rhodopsin family), 0.2697 PF00378 Enoyl-CoA hydratase/isomerase family 0.0363 PF01564 Spermine/spermidine synthase SUB361 C(~Cl)(~Cl) 0.3438 PF00153 Mitochondrial carrier protein 0.1942 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0961 PF00079 Serpin (serine protease inhibitor), SUB685 O=C-C-C-C-C 0.3434 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 0.2078 PF00001 7 transmembrane receptor (rhodopsin family), 0.1164 PF00155 Aminotransferase class I and II 0.1093 PF00850 Histone deacetylase domain 0.1077 PF07645 Calcium-binding EGF domain 0.0709 PF00248 Aldo/keto reductase family 0.0500 PF00202 Aminotransferase class-III 0.0434 PF00487 Fatty acid desaturase 0.0379 PF00501 AMP-binding enzyme 0.0001 PF07706 Aminotransferase ubiquitination site SUB716 Cc1ccc(S)cc1 0.3410 PF00005 ABC transporter 0.1190 PF00194 Eukaryotic-type carbonic anhydrase SUB625 O=C-C:C-N 0.3400 PF00071 Ras family 0.1816 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.1703 PF00001 7 transmembrane receptor (rhodopsin family), 0.1133 PF00028 Cadherin domain 0.1087 PF00493 MCM2/3/5 family 0.0695 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0411 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0002 PF08063 PADR1 (NUC008), domain 0.0001 PF00536 SAM domain (Sterile alpha motif), 0.0001 PF00644 Poly(ADP-ribose), polymerase catalytic domain SUB699 O-C-C-C-C-C-C-C 0.3350 PF00664 ABC transporter transmembrane region 0.3176 PF00579 tRNA synthetases class I (W and Y), 0.2376 PF00005 ABC transporter 0.2250 PF03099 Biotin/lipoate A/B protein ligase family 0.1952 PF01477 PLAT/LH2 domain 0.1003 PF00105 Zinc finger, C4 type (two domains), 0.0348 PF07706 Aminotransferase ubiquitination site 0.0043 PF01151 GNS1/SUR4 family SUB738 Cc1cc(N)ccc1 0.3297 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.3206 PF00324 Amino acid permease 0.3164 PF02394 Interleukin-1 propeptide 0.2978 PF01122 Eukaryotic cobalamin-binding protein 0.2824 PF00175 Oxidoreductase NAD-binding domain 0.2694 PF00105 Zinc finger, C4 type (two domains), 0.2074 PF00340 Interleukin-1 / 18 0.1609 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1544 PF01061 ABC-2 type transporter 0.1378 PF03002 Somatostatin/Cortistatin family 0.1377 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1237 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0780 PF01403 Sema domain 0.0704 PF00792 Phosphoinositide 3-kinase C2 0.0648 PF00017 SH2 domain 0.0377 PF01437 Plexin repeat SUB626 O=C-C:C-O 0.3296 PF00018 SH3 domain 0.2643 PF00520 Ion transport protein 0.2575 PF01007 Inward rectifier potassium channel SUB259 >= 2 hetero-aromatic rings 0.3294 PF00520 Ion transport protein 0.3108 PF00017 SH2 domain 0.0868 PF00069 Protein kinase domain 0.0731 PF00067 Cytochrome P450 0.0309 PF00005 ABC transporter 0.0007 PF00001 7 transmembrane receptor (rhodopsin family), SUB592 Cl-C-C-C-C 0.3277 PF03630 Fumble 0.1448 PF03073 TspO/MBR family 0.0380 PF00229 TNF(Tumour Necrosis Factor), family SUB577 N=C-C:C-[#1] 0.3274 PF00106 short chain dehydrogenase 0.2532 PF00089 Trypsin 0.2207 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1888 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.1258 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0721 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0670 PF03073 TspO/MBR family 0.0278 PF08240 Alcohol dehydrogenase GroES-like domain 0.0099 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain SUB438 C(-C)(-N)(=C) 0.3271 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.3270 PF00520 Ion transport protein 0.1521 PF00194 Eukaryotic-type carbonic anhydrase 0.0856 PF00051 Kringle domain 0.0326 PF03098 Animal haem peroxidase 0.0322 PF00092 von Willebrand factor type A domain 0.0143 PF00822 PMP-22/EMP/MP20/Claudin family 0.0119 PF00089 Trypsin SUB533 S-C:C-[#1] 0.3267 PF00104 Ligand-binding domain of nuclear hormone receptor 0.2604 PF00045 Hemopexin 0.2354 PF01471 Putative peptidoglycan binding domain 0.1361 PF08403 Amino acid permease N-terminal 0.0519 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0013 PF00105 Zinc finger, C4 type (two domains), SUB454 N(-C)(=C) 0.3267 PF00069 Protein kinase domain 0.1083 PF00051 Kringle domain 0.0930 PF03073 TspO/MBR family 0.0654 PF00464 Serine hydroxymethyltransferase 0.0483 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0163 PF00089 Trypsin SUB693 O=C-C-C-C-C-C 0.3265 PF00089 Trypsin 0.2715 PF00059 Lectin C-type domain 0.1295 PF00579 tRNA synthetases class I (W and Y), 0.0773 PF08127 Peptidase family C1 propeptide 0.0421 PF04704 Zfx / Zfy transcription activation region 0.0154 PF03099 Biotin/lipoate A/B protein ligase family 0.0022 PF01279 Parathyroid hormone family SUB476 S-C=N-C 0.3255 PF00287 Sodium / potassium ATPase beta chain 0.1476 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0682 PF05193 Peptidase M16 inactive domain 0.0666 PF04679 ATP dependent DNA ligase C terminal region 0.0308 PF01068 ATP dependent DNA ligase domain SUB489 N-C=N-[#1] 0.3254 PF00089 Trypsin 0.2595 PF00002 7 transmembrane receptor (Secretin family), 0.2269 PF02807 ATP:guanido phosphotransferase, N-terminal domain 0.2195 PF10397 Adenylosuccinate lyase C-terminus 0.1710 PF02793 Hormone receptor domain 0.1477 PF01068 ATP dependent DNA ligase domain 0.0863 PF00221 Phenylalanine and histidine ammonia-lyase 0.0839 PF04679 ATP dependent DNA ligase C terminal region 0.0548 PF00217 ATP:guanido phosphotransferase, C-terminal catalytic domain SUB315 O-P 0.3177 PF00929 Exonuclease 0.2329 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.1860 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.1712 PF03770 Inositol polyphosphate kinase 0.1265 PF02214 K+ channel tetramerisation domain 0.0851 PF00316 Fructose-1-6-bisphosphatase 0.0749 PF02441 Flavoprotein 0.0694 PF00018 SH3 domain 0.0355 PF08674 Acetylcholinesterase tetramerisation domain 0.0318 PF00146 NADH dehydrogenase 0.0244 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0235 PF02666 Phosphatidylserine decarboxylase 0.0233 PF01033 Somatomedin B domain 0.0058 PF00692 dUTPase 0.0052 PF11404 Potassium voltage-gated channel SUB668 C=C-C-O-[#1] 0.3169 PF00102 Protein-tyrosine phosphatase 0.2407 PF00171 Aldehyde dehydrogenase family 0.1947 PF00001 7 transmembrane receptor (rhodopsin family), 0.1544 PF01042 Endoribonuclease L-PSP 0.0998 PF00106 short chain dehydrogenase 0.0521 PF07885 Ion channel 0.0208 PF00650 CRAL/TRIO domain 0.0171 PF03765 CRAL/TRIO, N-terminus SUB637 C-N-C-N-C 0.3152 PF00225 Kinesin motor domain 0.2354 PF00115 Cytochrome C and Quinol oxidase polypeptide I 0.0922 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0699 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0621 PF00757 Furin-like cysteine rich region 0.0442 PF01030 Receptor L domain 0.0261 PF00067 Cytochrome P450 SUB531 N:C-C:C 0.3133 PF02196 Raf-like Ras-binding domain 0.1334 PF02803 Thiolase, C-terminal domain 0.1145 PF00108 Thiolase, N-terminal domain 0.0942 PF09027 GTPase binding 0.0890 PF00291 Pyridoxal-phosphate dependent enzyme 0.0870 PF11555 EGFR receptor inhibitor Mig-6 0.0341 PF01467 Cytidylyltransferase SUB257 >= 1 hetero-aromatic ring 0.3113 PF00067 Cytochrome P450 SUB822 CC1C(N)CCCC1 0.3084 PF02166 Androgen receptor 0.2457 PF00653 Inhibitor of Apoptosis domain 0.1636 PF00135 Carboxylesterase 0.1258 PF02060 Slow voltage-gated potassium channel 0.0330 PF01582 TIR domain SUB1 >= 4 H 0.3081 PF08674 Acetylcholinesterase tetramerisation domain 0.1655 PF00043 Glutathione S-transferase, C-terminal domain 0.1519 PF00248 Aldo/keto reductase family 0.1505 PF00102 Protein-tyrosine phosphatase 0.1345 PF00079 Serpin (serine protease inhibitor), 0.1286 PF00171 Aldehyde dehydrogenase family 0.0778 PF00560 Leucine Rich Repeat 0.0698 PF00107 Zinc-binding dehydrogenase 0.0070 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0025 PF06079 Apyrase SUB768 Sc1c(N)cccc1 0.3076 PF00520 Ion transport protein 0.0002 PF06512 Sodium ion transport-associated SUB153 >= 2 saturated or aromatic nitrogen-containing ring size 5 0.3072 PF00028 Cadherin domain 0.2414 PF01208 Uroporphyrinogen decarboxylase (URO-D), SUB653 O-C:C:C-N 0.3072 PF00123 Peptide hormone 0.2365 PF00001 7 transmembrane receptor (rhodopsin family), 0.2220 PF03508 Gap junction alpha-1 protein (Cx43), 0.1462 PF00029 Connexin 0.1152 PF08742 C8 domain 0.0681 PF05790 Immunoglobulin C2-set domain 0.0413 PF10582 Gap junction channel protein cysteine-rich domain 0.0302 PF01826 Trypsin Inhibitor like cysteine rich domain SUB747 Sc1cc(N)ccc1 0.3062 PF03372 Endonuclease/Exonuclease/phosphatase family SUB217 >= 1 saturated or aromatic heteroatom-containing ring size 7 0.3055 PF00149 Calcineurin-like phosphoesterase 0.2386 PF00001 7 transmembrane receptor (rhodopsin family), 0.1889 PF00169 PH domain SUB48 >= 2 I 0.3045 PF00105 Zinc finger, C4 type (two domains), SUB450 C(-N)(=C) 0.3026 PF01007 Inward rectifier potassium channel 0.1227 PF03098 Animal haem peroxidase SUB347 C(~C)(~H)(~O) 0.3024 PF00089 Trypsin 0.2433 PF01243 Pyridoxamine 5"-phosphate oxidase 0.2298 PF00171 Aldehyde dehydrogenase family 0.2174 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.1945 PF00229 TNF(Tumour Necrosis Factor), family 0.1662 PF00343 Carbohydrate phosphorylase 0.1457 PF06512 Sodium ion transport-associated 0.1443 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0985 PF01023 S-100/ICaBP type calcium binding domain 0.0530 PF00084 Sushi domain (SCR repeat), 0.0258 PF02155 Glucocorticoid receptor SUB388 C(:C)(:N) 0.3006 PF00001 7 transmembrane receptor (rhodopsin family), SUB229 >= 1 saturated or aromatic carbon-only ring size 8 0.2995 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0423 PF02931 Neurotransmitter-gated ion-channel ligand binding domain SUB393 N(~C)(~C)(~H) 0.2988 PF07645 Calcium-binding EGF domain 0.1897 PF00328 Histidine acid phosphatase 0.1835 PF00583 Acetyltransferase (GNAT), family 0.1499 PF00069 Protein kinase domain 0.1398 PF00229 TNF(Tumour Necrosis Factor), family 0.1155 PF00059 Lectin C-type domain 0.0561 PF00214 Calcitonin / CGRP / IAPP family 0.0131 PF09127 Leukotriene A4 hydrolase, C-terminal 0.0101 PF00521 DNA gyrase/topoisomerase IV, subunit A SUB453 C(-O)(=O) 0.2972 PF00194 Eukaryotic-type carbonic anhydrase 0.2876 PF01369 Sec7 domain 0.2013 PF00060 Ligand-gated ion channel 0.1780 PF01431 Peptidase family M13 0.1504 PF07648 Kazal-type serine protease inhibitor domain 0.1393 PF01180 Dihydroorotate dehydrogenase 0.1238 PF01699 Sodium/calcium exchanger protein 0.1156 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.1009 PF01266 FAD dependent oxidoreductase 0.0590 PF02970 Tubulin binding cofactor A 0.0474 PF00169 PH domain 0.0461 PF02785 Biotin carboxylase C-terminal domain 0.0434 PF07706 Aminotransferase ubiquitination site 0.0278 PF04952 Succinylglutamate desuccinylase / Aspartoacylase family 0.0272 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0239 PF03098 Animal haem peroxidase 0.0190 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0008 PF00074 Pancreatic ribonuclease 0.0004 PF00682 HMGL-like SUB800 CC1CC(S)CCC1 0.2966 PF00001 7 transmembrane receptor (rhodopsin family), SUB324 P-H 0.2949 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0350 PF00069 Protein kinase domain SUB258 >= 2 aromatic rings 0.2948 PF00520 Ion transport protein 0.1450 PF00576 HIUase/Transthyretin family 0.1150 PF03623 Focal adhesion targeting region 0.1077 PF03520 KCNQ voltage-gated potassium channel 0.0951 PF00079 Serpin (serine protease inhibitor), 0.0657 PF00675 Insulinase (Peptidase family M16), 0.0645 PF00069 Protein kinase domain 0.0597 PF12497 Estrogen receptor beta 0.0517 PF05193 Peptidase M16 inactive domain 0.0098 PF00667 FAD binding domain 0.0075 PF00258 Flavodoxin SUB684 N-C-C-C-C-C 0.2944 PF00001 7 transmembrane receptor (rhodopsin family), 0.1680 PF00017 SH2 domain 0.1603 PF03171 2OG-Fe(II), oxygenase superfamily 0.0733 PF02159 Oestrogen receptor 0.0341 PF00057 Low-density lipoprotein receptor domain class A 0.0326 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 0.0175 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SUB167 >= 4 saturated or aromatic nitrogen-containing ring size 5 0.2928 PF00001 7 transmembrane receptor (rhodopsin family), 0.1823 PF01208 Uroporphyrinogen decarboxylase (URO-D), SUB689 C-C-C-C-C-C-C 0.2914 PF01593 Flavin containing amine oxidoreductase 0.1587 PF00850 Histone deacetylase domain 0.0541 PF00001 7 transmembrane receptor (rhodopsin family), SUB401 N(~H)(:C)(:C) 0.2907 PF05790 Immunoglobulin C2-set domain 0.1286 PF00656 Caspase domain 0.1046 PF01387 Synuclein 0.0458 PF00001 7 transmembrane receptor (rhodopsin family), 0.0439 PF01231 Indoleamine 2,3-dioxygenase 0.0416 PF00458 WHEP-TRS domain SUB819 CC1C(C)CCCC1 0.2899 PF01234 NNMT/PNMT/TEMT family 0.1177 PF00433 Protein kinase C terminal domain SUB117 >= 1 saturated or aromatic carbon-only ring size 3 0.2896 PF01244 Membrane dipeptidase (Peptidase family M19), 0.1621 PF01160 Vertebrate endogenous opioids neuropeptide 0.1205 PF00069 Protein kinase domain SUB384 C(~S)(:C) 0.2896 PF00069 Protein kinase domain 0.0027 PF00102 Protein-tyrosine phosphatase SUB540 N=C-C-[#1] 0.2890 PF00005 ABC transporter 0.0715 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0440 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0379 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0132 PF00042 Globin 0.0079 PF03953 Tubulin C-terminal domain 0.0052 PF00001 7 transmembrane receptor (rhodopsin family), 0.0044 PF00091 Tubulin/FtsZ family, GTPase domain 0.0017 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0007 PF08127 Peptidase family C1 propeptide SUB544 O-C:C-N 0.2885 PF00294 pfkB family carbohydrate kinase 0.0710 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), SUB785 OC1CCC(N)CC1 0.2880 PF07885 Ion channel 0.0173 PF06512 Sodium ion transport-associated 0.0125 PF00656 Caspase domain SUB354 C(~C)(~S) 0.2874 PF00656 Caspase domain 0.2095 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.1421 PF00108 Thiolase, N-terminal domain 0.1146 PF02803 Thiolase, C-terminal domain 0.0776 PF00689 Cation transporting ATPase, C-terminus 0.0577 PF00690 Cation transporter/ATPase, N-terminus 0.0312 PF00958 GMP synthase C terminal domain 0.0004 PF01234 NNMT/PNMT/TEMT family 0.0001 PF00433 Protein kinase C terminal domain SUB442 C(-C)(=C) 0.2871 PF00001 7 transmembrane receptor (rhodopsin family), 0.1548 PF00005 ABC transporter 0.0899 PF00664 ABC transporter transmembrane region 0.0401 PF00501 AMP-binding enzyme SUB505 N:C:N-C 0.2870 PF00005 ABC transporter 0.1062 PF00899 ThiF family 0.0430 PF00478 IMP dehydrogenase / GMP reductase domain 0.0170 PF00067 Cytochrome P450 0.0078 PF00690 Cation transporter/ATPase, N-terminus 0.0066 PF00300 Phosphoglycerate mutase family SUB643 O-C-C-C=O 0.2863 PF00454 Phosphatidylinositol 3- and 4-kinase 0.2601 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.2284 PF00405 Transferrin 0.2249 PF00001 7 transmembrane receptor (rhodopsin family), 0.1725 PF00291 Pyridoxal-phosphate dependent enzyme 0.1159 PF00273 Serum albumin family 0.1060 PF01023 S-100/ICaBP type calcium binding domain 0.0934 PF02666 Phosphatidylserine decarboxylase 0.0692 PF03034 Phosphatidyl serine synthase 0.0678 PF01187 Macrophage migration inhibitory factor (MIF), 0.0618 PF00005 ABC transporter 0.0562 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0537 PF00271 Helicase conserved C-terminal domain 0.0467 PF01202 Shikimate kinase 0.0447 PF01130 CD36 family 0.0156 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0019 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0004 PF00091 Tubulin/FtsZ family, GTPase domain 0.0001 PF00656 Caspase domain SUB612 N-C-C-N-C 0.2861 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.1576 PF00364 Biotin-requiring enzyme 0.1257 PF07690 Major Facilitator Superfamily 0.1124 PF07686 Immunoglobulin V-set domain 0.1002 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0861 PF09027 GTPase binding 0.0668 PF00689 Cation transporting ATPase, C-terminus 0.0576 PF11555 EGFR receptor inhibitor Mig-6 0.0465 PF01061 ABC-2 type transporter 0.0399 PF02798 Glutathione S-transferase, N-terminal domain 0.0169 PF00214 Calcitonin / CGRP / IAPP family 0.0155 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SUB396 N(~C)(~O) 0.2857 PF00850 Histone deacetylase domain 0.2199 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.1149 PF02867 Ribonucleotide reductase, barrel domain 0.0939 PF01327 Polypeptide deformylase 0.0716 PF01180 Dihydroorotate dehydrogenase 0.0112 PF03098 Animal haem peroxidase SUB22 >= 8 O 0.2857 PF01118 Semialdehyde dehydrogenase, NAD binding domain 0.2727 PF03034 Phosphatidyl serine synthase 0.2618 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.2604 PF02779 Transketolase, pyrimidine binding domain 0.1795 PF00122 E1-E2 ATPase 0.1671 PF00378 Enoyl-CoA hydratase/isomerase family 0.1558 PF00171 Aldehyde dehydrogenase family 0.1231 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.1202 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0920 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0687 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0680 PF02666 Phosphatidylserine decarboxylase 0.0583 PF01467 Cytidylyltransferase 0.0508 PF00176 SNF2 family N-terminal domain SUB700 O-C-C-C-C-C(C)-C 0.2853 PF01401 Angiotensin-converting enzyme 0.2217 PF00069 Protein kinase domain 0.1236 PF01842 ACT domain 0.1211 PF07965 Integrin beta tail domain 0.1133 PF01023 S-100/ICaBP type calcium binding domain 0.1039 PF01231 Indoleamine 2,3-dioxygenase 0.1028 PF00042 Globin 0.0772 PF00520 Ion transport protein 0.0754 PF02159 Oestrogen receptor 0.0553 PF00045 Hemopexin 0.0511 PF01471 Putative peptidoglycan binding domain 0.0417 PF00571 CBS domain 0.0319 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0272 PF08725 Integrin beta cytoplasmic domain 0.0139 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0104 PF02180 Bcl-2 homology region 4 0.0003 PF07966 A1 Propeptide SUB597 N=C-N-C-C 0.2843 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.2029 PF01048 Phosphorylase superfamily 0.1367 PF00689 Cation transporting ATPase, C-terminus 0.1063 PF00217 ATP:guanido phosphotransferase, C-terminal catalytic domain 0.0638 PF02807 ATP:guanido phosphotransferase, N-terminal domain 0.0339 PF00690 Cation transporter/ATPase, N-terminus 0.0154 PF00043 Glutathione S-transferase, C-terminal domain 0.0125 PF00001 7 transmembrane receptor (rhodopsin family), 0.0037 PF02798 Glutathione S-transferase, N-terminal domain SUB44 >= 1 Br 0.2841 PF00001 7 transmembrane receptor (rhodopsin family), 0.1218 PF02201 SWIB/MDM2 domain SUB488 N-C=N-C 0.2814 PF00206 Lyase 0.1601 PF01571 Aminomethyltransferase folate-binding domain 0.1158 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0252 PF01048 Phosphorylase superfamily 0.0198 PF00069 Protein kinase domain SUB827 OC1C(N)CCCC1 0.2804 PF00170 bZIP transcription factor SUB583 C-C-C-C-C 0.2800 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.1272 PF03171 2OG-Fe(II), oxygenase superfamily 0.0003 PF07706 Aminotransferase ubiquitination site SUB2 >= 8 H 0.2778 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.1909 PF00043 Glutathione S-transferase, C-terminal domain 0.1091 PF00089 Trypsin 0.0745 PF00474 Sodium:solute symporter family 0.0266 PF00069 Protein kinase domain 0.0197 PF08674 Acetylcholinesterase tetramerisation domain 0.0009 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0008 PF00169 PH domain SUB19 >= 1 O 0.2768 PF01180 Dihydroorotate dehydrogenase 0.1096 PF00576 HIUase/Transthyretin family 0.0064 PF00194 Eukaryotic-type carbonic anhydrase 0.0022 PF00105 Zinc finger, C4 type (two domains), SUB415 S(~C)(~O) 0.2761 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 0.1336 PF00186 Dihydrofolate reductase 0.0588 PF01007 Inward rectifier potassium channel 0.0276 PF08403 Amino acid permease N-terminal 0.0043 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0030 PF03098 Animal haem peroxidase SUB436 C(-C)(-H)(=N) 0.2744 PF04389 Peptidase family M28 0.2581 PF00001 7 transmembrane receptor (rhodopsin family), 0.0844 PF08127 Peptidase family C1 propeptide 0.0009 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB214 >= 1 any ring size 7 0.2717 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.2426 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1946 PF00169 PH domain 0.0500 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 0.0274 PF00209 Sodium:neurotransmitter symporter family SUB34 >= 1 S 0.2712 PF00167 Fibroblast growth factor 0.2170 PF00273 Serum albumin family 0.1384 PF00092 von Willebrand factor type A domain 0.1057 PF00822 PMP-22/EMP/MP20/Claudin family 0.0723 PF00060 Ligand-gated ion channel 0.0141 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0037 PF01234 NNMT/PNMT/TEMT family SUB465 N-C-C=C 0.2702 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.2409 PF03953 Tubulin C-terminal domain 0.2124 PF00091 Tubulin/FtsZ family, GTPase domain SUB573 N:C:N:C 0.2693 PF00821 Phosphoenolpyruvate carboxykinase 0.1001 PF00478 IMP dehydrogenase / GMP reductase domain 0.0950 PF00899 ThiF family 0.0885 PF01591 6-phosphofructo-2-kinase 0.0228 PF00690 Cation transporter/ATPase, N-terminus 0.0138 PF00067 Cytochrome P450 0.0042 PF01030 Receptor L domain SUB582 O=C-C-C-O 0.2669 PF00005 ABC transporter 0.2545 PF01187 Macrophage migration inhibitory factor (MIF), 0.2472 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.1934 PF00405 Transferrin 0.1733 PF00454 Phosphatidylinositol 3- and 4-kinase 0.1666 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.1256 PF00520 Ion transport protein 0.1183 PF00342 Phosphoglucose isomerase 0.1087 PF00001 7 transmembrane receptor (rhodopsin family), 0.1030 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0946 PF03034 Phosphatidyl serine synthase 0.0866 PF01202 Shikimate kinase 0.0702 PF00271 Helicase conserved C-terminal domain 0.0318 PF00091 Tubulin/FtsZ family, GTPase domain 0.0312 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0252 PF02666 Phosphatidylserine decarboxylase 0.0182 PF01130 CD36 family 0.0097 PF02928 C5HC2 zinc finger 0.0092 PF00656 Caspase domain 0.0087 PF00168 C2 domain 0.0078 PF00273 Serum albumin family 0.0013 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0001 PF03953 Tubulin C-terminal domain SUB179 >= 1 any ring size 6 0.2658 PF00089 Trypsin 0.2416 PF00305 Lipoxygenase 0.1760 PF00106 short chain dehydrogenase 0.0980 PF08534 Redoxin 0.0147 PF00343 Carbohydrate phosphorylase 0.0122 PF00105 Zinc finger, C4 type (two domains), SUB579 C-C:C-C:C 0.2647 PF00209 Sodium:neurotransmitter symporter family SUB300 N-H 0.2634 PF06512 Sodium ion transport-associated 0.2472 PF00001 7 transmembrane receptor (rhodopsin family), 0.1961 PF00520 Ion transport protein 0.1209 PF00069 Protein kinase domain 0.0124 PF00092 von Willebrand factor type A domain SUB523 C-N-N-[#1] 0.2614 PF02025 Interleukin 5 0.2443 PF00001 7 transmembrane receptor (rhodopsin family), 0.2273 PF04042 DNA polymerase alpha/epsilon subunit B 0.1308 PF01179 Copper amine oxidase, enzyme domain 0.0159 PF08418 DNA polymerase alpha subunit B N-terminal SUB335 C(~C)(~C)(~C)(~C) 0.2613 PF00653 Inhibitor of Apoptosis domain 0.1445 PF08384 Pro-opiomelanocortin, N-terminal region 0.1370 PF00976 Corticotropin ACTH domain 0.1264 PF00106 short chain dehydrogenase 0.1130 PF00067 Cytochrome P450 0.0801 PF00439 Bromodomain 0.0479 PF00040 Fibronectin type II domain 0.0315 PF00890 FAD binding domain 0.0306 PF03137 Organic Anion Transporter Polypeptide (OATP), family SUB772 Nc1c(Cl)cccc1 0.2591 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0004 PF02932 Neurotransmitter-gated ion-channel transmembrane region SUB710 C-C(C)-C-C-C 0.2553 PF00001 7 transmembrane receptor (rhodopsin family), 0.2305 PF00343 Carbohydrate phosphorylase 0.1674 PF01094 Receptor family ligand binding region 0.0748 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0420 PF00248 Aldo/keto reductase family 0.0278 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0146 PF00069 Protein kinase domain 0.0057 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus SUB479 S-C=N-[#1] 0.2551 PF00287 Sodium / potassium ATPase beta chain SUB262 >= 4 aromatic rings 0.2542 PF00089 Trypsin 0.1489 PF00493 MCM2/3/5 family 0.0960 PF00018 SH3 domain 0.0196 PF00989 PAS fold 0.0125 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF00174 Oxidoreductase molybdopterin binding domain SUB357 C(~C)(:C)(:C) 0.2535 PF00089 Trypsin 0.0278 PF01431 Peptidase family M13 SUB562 Cl-C-C=O 0.2510 PF00591 Glycosyl transferase family, a/b domain 0.1443 PF07831 Pyrimidine nucleoside phosphorylase C-terminal domain 0.1047 PF02885 Glycosyl transferase family, helical bundle domain SUB24 >= 1 F 0.2509 PF00989 PAS fold 0.2386 PF00248 Aldo/keto reductase family 0.2182 PF01180 Dihydroorotate dehydrogenase 0.1647 PF08996 DNA Polymerase alpha zinc finger 0.1063 PF02867 Ribonucleotide reductase, barrel domain 0.0479 PF03477 ATP cone domain 0.0412 PF00317 Ribonucleotide reductase, all-alpha domain 0.0152 PF00136 DNA polymerase family B 0.0019 PF03104 DNA polymerase family B, exonuclease domain SUB419 C=N 0.2498 PF02898 Nitric oxide synthase, oxygenase domain 0.2492 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.1410 PF00051 Kringle domain 0.0397 PF00001 7 transmembrane receptor (rhodopsin family), SUB478 N-N-C:C 0.2495 PF03098 Animal haem peroxidase SUB591 C-C:C-O-[#1] 0.2484 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.2096 PF00069 Protein kinase domain 0.1549 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1537 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1083 PF00105 Zinc finger, C4 type (two domains), 0.0853 PF00225 Kinesin motor domain SUB466 O=S-C-C 0.2460 PF01590 GAF domain 0.1515 PF00664 ABC transporter transmembrane region 0.1422 PF08403 Amino acid permease N-terminal 0.1147 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0973 PF00045 Hemopexin 0.0800 PF00690 Cation transporter/ATPase, N-terminus 0.0723 PF00689 Cation transporting ATPase, C-terminus 0.0320 PF01471 Putative peptidoglycan binding domain SUB463 O-C-C=O 0.2459 PF00557 Metallopeptidase family M24 0.1562 PF00135 Carboxylesterase 0.1462 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0843 PF00224 Pyruvate kinase, barrel domain 0.0526 PF02887 Pyruvate kinase, alpha/beta domain 0.0435 PF00091 Tubulin/FtsZ family, GTPase domain 0.0363 PF03953 Tubulin C-terminal domain 0.0358 PF03949 Malic enzyme, NAD binding domain 0.0120 PF00102 Protein-tyrosine phosphatase SUB430 C(#N)(-C) 0.2446 PF00625 Guanylate kinase 0.2406 PF01007 Inward rectifier potassium channel SUB587 C-S-C-C-C 0.2440 PF02772 S-adenosylmethionine synthetase, central domain 0.2263 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.2252 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.1198 PF02574 Homocysteine S-methyltransferase 0.0284 PF12497 Estrogen receptor beta 0.0234 PF00043 Glutathione S-transferase, C-terminal domain 0.0191 PF00856 SET domain SUB600 [#1]-C-C=C-[#1] 0.2440 PF00487 Fatty acid desaturase 0.2333 PF00001 7 transmembrane receptor (rhodopsin family), 0.2258 PF00171 Aldehyde dehydrogenase family 0.0750 PF00104 Ligand-binding domain of nuclear hormone receptor SUB512 S=C-N-[#1] 0.2433 PF03098 Animal haem peroxidase 0.0003 PF01404 Ephrin receptor ligand binding domain 0.0002 PF00041 Fibronectin type III domain SUB446 C(-H)(-N)(=C) 0.2389 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.1848 PF00105 Zinc finger, C4 type (two domains), 0.1710 PF08240 Alcohol dehydrogenase GroES-like domain 0.1474 PF03414 Glycosyltransferase family 6 0.1349 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0902 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0734 PF00357 Integrin alpha cytoplasmic region 0.0704 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0555 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0450 PF00107 Zinc-binding dehydrogenase 0.0389 PF00001 7 transmembrane receptor (rhodopsin family), 0.0263 PF00676 Dehydrogenase E1 component 0.0244 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0191 PF03949 Malic enzyme, NAD binding domain 0.0054 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0016 PF00104 Ligand-binding domain of nuclear hormone receptor SUB477 C-O-C=C 0.2386 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0350 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0190 PF08441 Integrin alpha SUB608 N-C-C-C:C 0.2383 PF00001 7 transmembrane receptor (rhodopsin family), 0.1943 PF00018 SH3 domain 0.1646 PF00209 Sodium:neurotransmitter symporter family 0.1453 PF00084 Sushi domain (SCR repeat), 0.0981 PF00155 Aminotransferase class I and II 0.0141 PF02159 Oestrogen receptor SUB518 N-N-C-N 0.2379 PF00001 7 transmembrane receptor (rhodopsin family), 0.1993 PF00209 Sodium:neurotransmitter symporter family 0.1722 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region SUB729 Nc1ccc(N)cc1 0.2370 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.1286 PF02166 Androgen receptor SUB610 Cl-C-C-N-C 0.2367 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0713 PF08377 MAP2/Tau projection domain 0.0242 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0097 PF03098 Animal haem peroxidase 0.0048 PF00001 7 transmembrane receptor (rhodopsin family), SUB260 >= 3 aromatic rings 0.2360 PF00074 Pancreatic ribonuclease 0.1441 PF01477 PLAT/LH2 domain 0.0917 PF00520 Ion transport protein 0.0450 PF02159 Oestrogen receptor 0.0396 PF00068 Phospholipase A2 0.0124 PF02180 Bcl-2 homology region 4 0.0043 PF00452 Apoptosis regulator proteins, Bcl-2 family SUB145 >= 1 saturated or aromatic carbon-only ring size 5 0.2356 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.1974 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0616 PF00884 Sulfatase SUB432 C(-C)(-C)(=N) 0.2350 PF00069 Protein kinase domain 0.1443 PF00343 Carbohydrate phosphorylase 0.1438 PF00005 ABC transporter 0.1075 PF01842 ACT domain SUB726 Sc1ccc(N)cc1 0.2346 PF00069 Protein kinase domain 0.1351 PF02146 Sir2 family SUB564 O-C-O-C 0.2343 PF00021 u-PAR/Ly-6 domain 0.2261 PF00860 Permease family 0.1366 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.1095 PF00059 Lectin C-type domain 0.0798 PF07654 Immunoglobulin C1-set domain 0.0509 PF00209 Sodium:neurotransmitter symporter family 0.0339 PF03171 2OG-Fe(II), oxygenase superfamily 0.0067 PF04711 Apolipoprotein A-II (ApoA-II), 0.0066 PF01094 Receptor family ligand binding region 0.0045 PF00067 Cytochrome P450 0.0003 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 SUB147 >= 1 saturated or aromatic heteroatom-containing ring size 5 0.2323 PF00478 IMP dehydrogenase / GMP reductase domain 0.1498 PF00474 Sodium:solute symporter family 0.1199 PF00001 7 transmembrane receptor (rhodopsin family), 0.0159 PF00170 bZIP transcription factor SUB137 >= 2 any ring size 4 0.2298 PF00069 Protein kinase domain 0.0222 PF00689 Cation transporting ATPase, C-terminus 0.0173 PF00702 haloacid dehalogenase-like hydrolase 0.0129 PF00122 E1-E2 ATPase 0.0019 PF00005 ABC transporter 0.0014 PF00690 Cation transporter/ATPase, N-terminus 0.0012 PF00664 ABC transporter transmembrane region SUB717 Cc1ccc(N)cc1 0.2297 PF02310 B12 binding domain 0.2040 PF00754 F5/8 type C domain 0.1522 PF02219 Methylenetetrahydrofolate reductase 0.1187 PF00105 Zinc finger, C4 type (two domains), 0.0874 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0784 PF00089 Trypsin 0.0755 PF00258 Flavodoxin 0.0740 PF00175 Oxidoreductase NAD-binding domain 0.0614 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0562 PF03024 Folate receptor family 0.0556 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0528 PF01437 Plexin repeat 0.0490 PF01403 Sema domain 0.0464 PF01571 Aminomethyltransferase folate-binding domain 0.0367 PF00084 Sushi domain (SCR repeat), 0.0272 PF01833 IPT/TIG domain 0.0001 PF00792 Phosphoinositide 3-kinase C2 SUB807 OC1CC(Cl)CCC1 0.2252 PF00043 Glutathione S-transferase, C-terminal domain SUB804 OC1CC(O)CCC1 0.2187 PF02121 Phosphatidylinositol transfer protein 0.1738 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1729 PF00459 Inositol monophosphatase family 0.0999 PF00001 7 transmembrane receptor (rhodopsin family), 0.0501 PF03623 Focal adhesion targeting region 0.0050 PF00373 FERM central domain SUB285 C-C 0.2166 PF09127 Leukotriene A4 hydrolase, C-terminal 0.2119 PF00273 Serum albumin family SUB556 N=C-C=C 0.2127 PF03073 TspO/MBR family 0.1893 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0812 PF00001 7 transmembrane receptor (rhodopsin family), 0.0478 PF03171 2OG-Fe(II), oxygenase superfamily 0.0368 PF03098 Animal haem peroxidase 0.0345 PF01712 Deoxynucleoside kinase SUB366 C(~H)(~N) 0.2123 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1714 PF03073 TspO/MBR family 0.1340 PF00520 Ion transport protein 0.1323 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1292 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.1080 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 0.0086 PF00024 PAN domain SUB780 CC1CCC(N)CC1 0.2118 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1714 PF00001 7 transmembrane receptor (rhodopsin family), 0.1552 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1520 PF00209 Sodium:neurotransmitter symporter family 0.0888 PF01571 Aminomethyltransferase folate-binding domain 0.0311 PF00067 Cytochrome P450 0.0253 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0019 PF00754 F5/8 type C domain SUB116 >= 1 any ring size 3 0.2104 PF01244 Membrane dipeptidase (Peptidase family M19), SUB165 >= 4 any ring size 5 0.2100 PF03308 ArgK protein 0.0800 PF01437 Plexin repeat 0.0170 PF01403 Sema domain SUB462 O-C-C=N 0.2069 PF00155 Aminotransferase class I and II 0.0928 PF01063 Aminotransferase class IV 0.0792 PF01212 Beta-eliminating lyase 0.0791 PF08742 C8 domain 0.0516 PF01068 ATP dependent DNA ligase domain 0.0460 PF00149 Calcineurin-like phosphoesterase 0.0447 PF00294 pfkB family carbohydrate kinase 0.0321 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0219 PF00001 7 transmembrane receptor (rhodopsin family), 0.0001 PF04679 ATP dependent DNA ligase C terminal region SUB284 C-H 0.2054 PF06617 M-phase inducer phosphatase 0.1865 PF00194 Eukaryotic-type carbonic anhydrase 0.1754 PF00107 Zinc-binding dehydrogenase 0.1678 PF00248 Aldo/keto reductase family 0.1675 PF00273 Serum albumin family 0.1666 PF08674 Acetylcholinesterase tetramerisation domain 0.1602 PF00576 HIUase/Transthyretin family 0.1160 PF09127 Leukotriene A4 hydrolase, C-terminal 0.0974 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0001 PF00581 Rhodanese-like domain SUB616 N-C-C-O-C 0.2043 PF00067 Cytochrome P450 0.1120 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1111 PF00059 Lectin C-type domain 0.0955 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0625 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0614 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0448 PF00023 Ankyrin repeat 0.0261 PF00209 Sodium:neurotransmitter symporter family SUB63 >= 1 Zn 0.2043 PF02798 Glutathione S-transferase, N-terminal domain SUB342 C(~C)(~C)(~O) 0.2029 PF03372 Endonuclease/Exonuclease/phosphatase family 0.1617 PF02779 Transketolase, pyrimidine binding domain 0.1298 PF02525 Flavodoxin-like fold 0.1114 PF02780 Transketolase, C-terminal domain 0.0968 PF00151 Lipase 0.0555 PF07686 Immunoglobulin V-set domain 0.0546 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0391 PF00069 Protein kinase domain 0.0337 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0255 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0009 PF02887 Pyruvate kinase, alpha/beta domain 0.0007 PF00224 Pyruvate kinase, barrel domain SUB362 C(~Cl)(~H) 0.2021 PF00418 Tau and MAP protein, tubulin-binding repeat 0.1318 PF00079 Serpin (serine protease inhibitor), 0.0809 PF08377 MAP2/Tau projection domain 0.0077 PF00173 Cytochrome b5-like Heme/Steroid binding domain SUB676 Br-C-C-C:C 0.2016 PF02201 SWIB/MDM2 domain SUB467 N#C-C=C 0.2003 PF00105 Zinc finger, C4 type (two domains), 0.1989 PF00104 Ligand-binding domain of nuclear hormone receptor SUB561 N-C-N-C 0.2003 PF02274 Amidinotransferase 0.1041 PF08403 Amino acid permease N-terminal 0.0905 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0852 PF00175 Oxidoreductase NAD-binding domain 0.0116 PF06512 Sodium ion transport-associated 0.0060 PF07992 Pyridine nucleotide-disulphide oxidoreductase SUB263 >= 4 hetero-aromatic rings 0.1984 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0971 PF01833 IPT/TIG domain 0.0729 PF01437 Plexin repeat SUB627 C-O-C:C-C 0.1962 PF00664 ABC transporter transmembrane region 0.0514 PF08441 Integrin alpha SUB549 O-C-C:C 0.1954 PF01477 PLAT/LH2 domain 0.0013 PF00027 Cyclic nucleotide-binding domain SUB514 S:C:C-[#1] 0.1946 PF00059 Lectin C-type domain SUB760 Cc1c(Cl)cccc1 0.1942 PF00069 Protein kinase domain 0.0616 PF07686 Immunoglobulin V-set domain SUB590 C-C:C-O-C 0.1924 PF00664 ABC transporter transmembrane region SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 0.1919 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.1825 PF00001 7 transmembrane receptor (rhodopsin family), 0.1800 PF03098 Animal haem peroxidase 0.1523 PF00343 Carbohydrate phosphorylase 0.1317 PF00017 SH2 domain 0.1281 PF02872 5"-nucleotidase, C-terminal domain 0.1108 PF00106 short chain dehydrogenase 0.0644 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0544 PF04716 ETC complex I subunit conserved region 0.0409 PF01231 Indoleamine 2,3-dioxygenase 0.0318 PF00069 Protein kinase domain 0.0276 PF00005 ABC transporter 0.0131 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0130 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0097 PF00441 Acyl-CoA dehydrogenase, C-terminal domain SUB744 Oc1cc(Cl)ccc1 0.1899 PF02798 Glutathione S-transferase, N-terminal domain SUB538 O=C-C-O 0.1897 PF00224 Pyruvate kinase, barrel domain 0.1427 PF00557 Metallopeptidase family M24 0.1142 PF00135 Carboxylesterase 0.1075 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0707 PF02887 Pyruvate kinase, alpha/beta domain 0.0645 PF00091 Tubulin/FtsZ family, GTPase domain 0.0424 PF00274 Fructose-bisphosphate aldolase class-I 0.0008 PF00102 Protein-tyrosine phosphatase 0.0006 PF03953 Tubulin C-terminal domain SUB743 Oc1cc(N)ccc1 0.1892 PF00123 Peptide hormone 0.1242 PF05790 Immunoglobulin C2-set domain 0.1027 PF03508 Gap junction alpha-1 protein (Cx43), 0.0949 PF00029 Connexin 0.0774 PF10582 Gap junction channel protein cysteine-rich domain 0.0716 PF00094 von Willebrand factor type D domain 0.0410 PF00214 Calcitonin / CGRP / IAPP family 0.0126 PF08742 C8 domain SUB426 P=O 0.1870 PF00017 SH2 domain 0.1809 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.1414 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.1032 PF02441 Flavoprotein 0.1026 PF00074 Pancreatic ribonuclease 0.0962 PF03770 Inositol polyphosphate kinase 0.0805 PF00018 SH3 domain 0.0594 PF00146 NADH dehydrogenase 0.0472 PF00929 Exonuclease 0.0287 PF02886 LBP / BPI / CETP family, C-terminal domain 0.0270 PF01273 LBP / BPI / CETP family, N-terminal domain 0.0266 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 0.0125 PF00316 Fructose-1-6-bisphosphatase 0.0096 PF11404 Potassium voltage-gated channel 0.0010 PF08674 Acetylcholinesterase tetramerisation domain SUB417 C=C 0.1852 PF00005 ABC transporter 0.0729 PF00001 7 transmembrane receptor (rhodopsin family), 0.0725 PF00664 ABC transporter transmembrane region 0.0366 PF00501 AMP-binding enzyme SUB510 Br-C:C-C 0.1851 PF02205 WH2 motif 0.0871 PF00641 Zn-finger in Ran binding protein and others SUB293 C-P 0.1849 PF00102 Protein-tyrosine phosphatase 0.1765 PF00348 Polyprenyl synthetase SUB492 C-N:C-[#1] 0.1812 PF00757 Furin-like cysteine rich region 0.1756 PF00045 Hemopexin 0.1706 PF01471 Putative peptidoglycan binding domain 0.1640 PF01030 Receptor L domain 0.0479 PF02196 Raf-like Ras-binding domain 0.0477 PF00571 CBS domain 0.0093 PF00478 IMP dehydrogenase / GMP reductase domain SUB620 O-C-C=C-C 0.1794 PF00702 haloacid dehalogenase-like hydrolase 0.1545 PF00001 7 transmembrane receptor (rhodopsin family), 0.1120 PF00822 PMP-22/EMP/MP20/Claudin family 0.0683 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0403 PF08035 Opioids neuropeptide 0.0344 PF03098 Animal haem peroxidase 0.0333 PF07648 Kazal-type serine protease inhibitor domain 0.0237 PF00976 Corticotropin ACTH domain 0.0180 PF08384 Pro-opiomelanocortin, N-terminal region 0.0113 PF06907 Latexin SUB566 C:C-O-C 0.1780 PF00664 ABC transporter transmembrane region 0.1762 PF01007 Inward rectifier potassium channel 0.0414 PF08441 Integrin alpha SUB565 C=C-C=C 0.1766 PF00069 Protein kinase domain 0.0071 PF02159 Oestrogen receptor 0.0033 PF00105 Zinc finger, C4 type (two domains), SUB532 S-C:C-C 0.1765 PF00102 Protein-tyrosine phosphatase SUB203 >= 4 saturated or aromatic heteroatom-containing ring size 6 0.1685 PF01462 Leucine rich repeat N-terminal domain 0.1384 PF03662 Glycosyl hydrolase family 79, N-terminal domain SUB504 Cl-C:C-[#1] 0.1682 PF00067 Cytochrome P450 0.0225 PF03073 TspO/MBR family 0.0120 PF00229 TNF(Tumour Necrosis Factor), family 0.0059 PF01477 PLAT/LH2 domain 0.0022 PF00194 Eukaryotic-type carbonic anhydrase SUB617 C:C:N:N:C 0.1679 PF00069 Protein kinase domain 0.0386 PF00106 short chain dehydrogenase SUB411 P(~C)(~C) 0.1661 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0826 PF00069 Protein kinase domain SUB655 N-C-N-C-C 0.1654 PF08403 Amino acid permease N-terminal 0.1561 PF10391 Fingers domain of DNA polymerase lambda 0.1110 PF08527 Protein-arginine deiminase (PAD), middle domain 0.0811 PF06512 Sodium ion transport-associated 0.0698 PF08526 Protein-arginine deiminase (PAD), N-terminal domain 0.0390 PF02274 Amidinotransferase 0.0346 PF01180 Dihydroorotate dehydrogenase 0.0334 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0104 PF00001 7 transmembrane receptor (rhodopsin family), 0.0001 PF00225 Kinesin motor domain SUB534 S-C:C-N 0.1638 PF00001 7 transmembrane receptor (rhodopsin family), 0.1160 PF00520 Ion transport protein 0.0008 PF00536 SAM domain (Sterile alpha motif), 0.0003 PF06512 Sodium ion transport-associated SUB443 C(-C)(=N) 0.1627 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0481 PF08127 Peptidase family C1 propeptide SUB390 C(:N)(:N) 0.1624 PF00478 IMP dehydrogenase / GMP reductase domain 0.0484 PF00689 Cation transporting ATPase, C-terminus 0.0198 PF00300 Phosphoglycerate mutase family 0.0085 PF01591 6-phosphofructo-2-kinase 0.0085 PF00757 Furin-like cysteine rich region 0.0004 PF01030 Receptor L domain 0.0003 PF00690 Cation transporter/ATPase, N-terminus SUB709 C-C(C)-C-C 0.1619 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1584 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1195 PF00413 Matrixin 0.1142 PF00664 ABC transporter transmembrane region 0.1069 PF01063 Aminotransferase class IV 0.1054 PF00043 Glutathione S-transferase, C-terminal domain 0.0881 PF01471 Putative peptidoglycan binding domain 0.0472 PF00045 Hemopexin 0.0443 PF02798 Glutathione S-transferase, N-terminal domain SUB380 C(~N)(:N) 0.1618 PF00069 Protein kinase domain 0.0203 PF01591 6-phosphofructo-2-kinase 0.0153 PF00300 Phosphoglycerate mutase family 0.0101 PF01030 Receptor L domain SUB301 N-N 0.1616 PF00079 Serpin (serine protease inhibitor), 0.0383 PF04042 DNA polymerase alpha/epsilon subunit B 0.0071 PF08418 DNA polymerase alpha subunit B N-terminal SUB658 C-N-C:C-C 0.1594 PF00001 7 transmembrane receptor (rhodopsin family), 0.1544 PF06512 Sodium ion transport-associated 0.0462 PF00550 Phosphopantetheine attachment site 0.0387 PF00005 ABC transporter 0.0234 PF02254 TrkA-N domain 0.0049 PF00850 Histone deacetylase domain 0.0001 PF03493 Calcium-activated BK potassium channel alpha subunit SUB539 N=C-C-C 0.1593 PF03073 TspO/MBR family SUB773 Nc1c(Br)cccc1 0.1569 PF00001 7 transmembrane receptor (rhodopsin family), SUB251 >= 1 saturated or aromatic nitrogen-containing ring size 10 0.1557 PF06512 Sodium ion transport-associated 0.0421 PF00042 Globin 0.0302 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0240 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0225 PF00135 Carboxylesterase 0.0115 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region SUB435 C(-C)(-H)(=C) 0.1555 PF00001 7 transmembrane receptor (rhodopsin family), 0.0628 PF00067 Cytochrome P450 0.0534 PF00273 Serum albumin family 0.0063 PF01007 Inward rectifier potassium channel 0.0057 PF00061 Lipocalin / cytosolic fatty-acid binding protein family SUB452 C(-N)(=O) 0.1539 PF01007 Inward rectifier potassium channel 0.1056 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0804 PF02008 CXXC zinc finger domain 0.0645 PF00045 Hemopexin 0.0468 PF00107 Zinc-binding dehydrogenase 0.0358 PF01471 Putative peptidoglycan binding domain 0.0103 PF01426 BAH domain 0.0076 PF00533 BRCA1 C Terminus (BRCT), domain 0.0057 PF06464 DMAP1-binding Domain SUB168 >= 4 saturated or aromatic heteroatom-containing ring size 5 0.1526 PF01833 IPT/TIG domain 0.0770 PF01403 Sema domain 0.0542 PF01437 Plexin repeat 0.0011 PF00174 Oxidoreductase molybdopterin binding domain SUB33 >= 4 P 0.1513 PF00069 Protein kinase domain 0.1159 PF00169 PH domain SUB372 C(~H)(:C)(:C) 0.1503 PF00069 Protein kinase domain 0.0754 PF00001 7 transmembrane receptor (rhodopsin family), 0.0245 PF00413 Matrixin SUB509 S=C-N-C 0.1500 PF00171 Aldehyde dehydrogenase family 0.1002 PF04679 ATP dependent DNA ligase C terminal region 0.0916 PF01404 Ephrin receptor ligand binding domain 0.0543 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0293 PF01068 ATP dependent DNA ligase domain 0.0101 PF00041 Fibronectin type III domain SUB593 N-C-C-C-C 0.1495 PF00102 Protein-tyrosine phosphatase 0.1472 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0009 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region SUB763 Oc1c(S)cccc1 0.1474 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0739 PF00001 7 transmembrane receptor (rhodopsin family), SUB10 >= 2 C 0.1464 PF00273 Serum albumin family 0.0646 PF03160 Calx-beta domain 0.0303 PF01370 NAD dependent epimerase/dehydratase family 0.0238 PF00576 HIUase/Transthyretin family SUB777 CC1CCC(C)CC1 0.1445 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0972 PF00664 ABC transporter transmembrane region 0.0235 PF00105 Zinc finger, C4 type (two domains), 0.0134 PF00005 ABC transporter SUB11 >= 4 C 0.1441 PF00051 Kringle domain 0.0651 PF00337 Galactoside-binding lectin 0.0103 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region SUB294 C-S 0.1422 PF00108 Thiolase, N-terminal domain 0.1086 PF00248 Aldo/keto reductase family 0.0948 PF02803 Thiolase, C-terminal domain 0.0783 PF00433 Protein kinase C terminal domain 0.0031 PF01234 NNMT/PNMT/TEMT family SUB474 S-C:N:C 0.1404 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0253 PF04679 ATP dependent DNA ligase C terminal region 0.0006 PF00536 SAM domain (Sterile alpha motif), SUB552 Cl-C-C-O 0.1404 PF00173 Cytochrome b5-like Heme/Steroid binding domain SUB40 >= 4 Cl 0.1380 PF00111 2Fe-2S iron-sulfur cluster binding domain SUB630 S-C:C:C-N 0.1337 PF00001 7 transmembrane receptor (rhodopsin family), 0.1105 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0397 PF02146 Sir2 family SUB508 C-C-S-C 0.1334 PF04321 RmlD substrate binding domain 0.0985 PF12497 Estrogen receptor beta SUB671 Br-C:C:C-C 0.1311 PF02201 SWIB/MDM2 domain SUB619 C:C-C-C:C 0.1310 PF06512 Sodium ion transport-associated SUB501 C-S-C:C 0.1288 PF07645 Calcium-binding EGF domain 0.0179 PF03098 Animal haem peroxidase SUB634 N-C-C:C-C 0.1287 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0846 PF00702 haloacid dehalogenase-like hydrolase SUB861 CC1C(C)CCC1 0.1286 PF00884 Sulfatase 0.1197 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0125 PF00273 Serum albumin family SUB667 C=C-C-O-C 0.1284 PF03953 Tubulin C-terminal domain 0.1258 PF00091 Tubulin/FtsZ family, GTPase domain 0.0927 PF00702 haloacid dehalogenase-like hydrolase 0.0851 PF00102 Protein-tyrosine phosphatase SUB821 CC1C(S)CCCC1 0.1270 PF03372 Endonuclease/Exonuclease/phosphatase family 0.1241 PF00001 7 transmembrane receptor (rhodopsin family), 0.0989 PF02146 Sir2 family 0.0409 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0032 PF00105 Zinc finger, C4 type (two domains), SUB344 C(~C)(~Cl)(~H) 0.1268 PF08377 MAP2/Tau projection domain 0.1082 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0904 PF00079 Serpin (serine protease inhibitor), 0.0542 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0430 PF00111 2Fe-2S iron-sulfur cluster binding domain SUB373 C(~H)(:C)(:N) 0.1261 PF00107 Zinc-binding dehydrogenase 0.0265 PF00702 haloacid dehalogenase-like hydrolase 0.0010 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0001 PF00266 Aminotransferase class-V 0.0001 PF00001 7 transmembrane receptor (rhodopsin family), SUB331 C(~Br)(:C) 0.1257 PF02201 SWIB/MDM2 domain 0.0111 PF00641 Zn-finger in Ran binding protein and others 0.0067 PF00568 WH1 domain SUB570 N-C-C-N 0.1233 PF00520 Ion transport protein 0.0961 PF07690 Major Facilitator Superfamily 0.0403 PF07686 Immunoglobulin V-set domain 0.0233 PF00001 7 transmembrane receptor (rhodopsin family), 0.0083 PF02798 Glutathione S-transferase, N-terminal domain SUB750 Nc1cc(N)ccc1 0.1198 PF00754 F5/8 type C domain SUB820 CC1C(O)CCCC1 0.1184 PF00001 7 transmembrane receptor (rhodopsin family), 0.0823 PF00554 Rel homology domain (RHD), 0.0479 PF00023 Ankyrin repeat 0.0239 PF00976 Corticotropin ACTH domain 0.0197 PF08384 Pro-opiomelanocortin, N-terminal region SUB391 N(~C)(~C) 0.1154 PF08674 Acetylcholinesterase tetramerisation domain 0.0063 PF00755 Choline/Carnitine o-acyltransferase 0.0060 PF00001 7 transmembrane receptor (rhodopsin family), SUB482 O-S-C:C 0.1140 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0018 PF00105 Zinc finger, C4 type (two domains), 0.0006 PF00337 Galactoside-binding lectin SUB385 C(:C)(:C) 0.1112 PF00005 ABC transporter SUB555 Br-C-C-C 0.1104 PF00641 Zn-finger in Ran binding protein and others 0.0775 PF02201 SWIB/MDM2 domain SUB654 O-C:C:C-O 0.1091 PF00478 IMP dehydrogenase / GMP reductase domain 0.1059 PF03623 Focal adhesion targeting region 0.0429 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0292 PF00069 Protein kinase domain 0.0089 PF00001 7 transmembrane receptor (rhodopsin family), SUB429 C(#C)(-H) 0.1086 PF00194 Eukaryotic-type carbonic anhydrase SUB400 N(~H)(:C) 0.1064 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0058 PF01048 Phosphorylase superfamily SUB485 N-C:N:C 0.1062 PF00108 Thiolase, N-terminal domain 0.0186 PF01591 6-phosphofructo-2-kinase 0.0025 PF00757 Furin-like cysteine rich region SUB789 SC1CCC(N)CC1 0.1051 PF00069 Protein kinase domain 0.0527 PF02146 Sir2 family SUB231 >= 1 saturated or aromatic heteroatom-containing ring size 8 0.1047 PF00341 Platelet-derived growth factor (PDGF), 0.0622 PF00001 7 transmembrane receptor (rhodopsin family), SUB152 >= 2 saturated or aromatic carbon-only ring size 5 0.1024 PF00233 3"5"-cyclic nucleotide phosphodiesterase SUB607 O-C:C-C-C 0.1014 PF00702 haloacid dehalogenase-like hydrolase SUB374 C(~H)(:N) 0.1005 PF00757 Furin-like cysteine rich region 0.0992 PF01030 Receptor L domain 0.0934 PF00478 IMP dehydrogenase / GMP reductase domain 0.0684 PF02196 Raf-like Ras-binding domain 0.0159 PF00069 Protein kinase domain SUB595 C-O-C-C=C 0.0998 PF00091 Tubulin/FtsZ family, GTPase domain 0.0960 PF03953 Tubulin C-terminal domain 0.0632 PF00102 Protein-tyrosine phosphatase SUB739 Cc1cc(Cl)ccc1 0.0990 PF00027 Cyclic nucleotide-binding domain 0.0876 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0689 PF00989 PAS fold 0.0056 PF02931 Neurotransmitter-gated ion-channel ligand binding domain SUB575 O-C-C:C-C 0.0988 PF00001 7 transmembrane receptor (rhodopsin family), 0.0044 PF00102 Protein-tyrosine phosphatase 0.0001 PF00027 Cyclic nucleotide-binding domain SUB497 N:N-C-[#1] 0.0976 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 0.0579 PF01033 Somatomedin B domain 0.0545 PF01223 DNA/RNA non-specific endonuclease SUB574 O-C-C=C 0.0976 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0927 PF03098 Animal haem peroxidase 0.0797 PF00822 PMP-22/EMP/MP20/Claudin family 0.0585 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0209 PF08035 Opioids neuropeptide 0.0146 PF00976 Corticotropin ACTH domain 0.0139 PF08384 Pro-opiomelanocortin, N-terminal region SUB586 C-C:C-N-C 0.0954 PF00001 7 transmembrane receptor (rhodopsin family), 0.0875 PF02254 TrkA-N domain 0.0702 PF00550 Phosphopantetheine attachment site 0.0019 PF06512 Sodium ion transport-associated 0.0002 PF00850 Histone deacetylase domain SUB605 C-O-C-C:C 0.0950 PF06512 Sodium ion transport-associated 0.0081 PF00102 Protein-tyrosine phosphatase SUB502 Cl-C:C-C 0.0938 PF00229 TNF(Tumour Necrosis Factor), family 0.0245 PF00194 Eukaryotic-type carbonic anhydrase 0.0025 PF01477 PLAT/LH2 domain 0.0005 PF03073 TspO/MBR family SUB243 >= 1 saturated or aromatic carbon-only ring size 9 0.0912 PF00884 Sulfatase 0.0042 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0018 PF00106 short chain dehydrogenase 0.0017 PF00762 Ferrochelatase SUB823 CC1C(Cl)CCCC1 0.0861 PF00079 Serpin (serine protease inhibitor), 0.0599 PF07686 Immunoglobulin V-set domain SUB399 N(~H)(~N) 0.0845 PF02025 Interleukin 5 0.0420 PF00001 7 transmembrane receptor (rhodopsin family), 0.0210 PF08418 DNA polymerase alpha subunit B N-terminal SUB810 SC1CC(N)CCC1 0.0839 PF03372 Endonuclease/Exonuclease/phosphatase family SUB402 N(~O)(~O) 0.0794 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0004 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily SUB195 >= 3 saturated or aromatic nitrogen-containing ring size 6 0.0769 PF01462 Leucine rich repeat N-terminal domain 0.0520 PF00754 F5/8 type C domain SUB511 [#1]-N-N-[#1] 0.0748 PF01179 Copper amine oxidase, enzyme domain 0.0645 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 0.0453 PF02727 Copper amine oxidase, N2 domain SUB481 C:S:C-C 0.0730 PF00001 7 transmembrane receptor (rhodopsin family), SUB765 Oc1c(Cl)cccc1 0.0713 PF00001 7 transmembrane receptor (rhodopsin family), SUB528 C:C:N-[#1] 0.0695 PF00001 7 transmembrane receptor (rhodopsin family), 0.0349 PF00458 WHEP-TRS domain 0.0040 PF01048 Phosphorylase superfamily 0.0001 PF05790 Immunoglobulin C2-set domain SUB218 >= 1 unsaturated non-aromatic carbon-only ring size 7 0.0687 PF03953 Tubulin C-terminal domain SUB496 C-N-C:C 0.0647 PF00702 haloacid dehalogenase-like hydrolase 0.0407 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0302 PF00550 Phosphopantetheine attachment site SUB461 C-C-C#C 0.0625 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0467 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0358 PF00194 Eukaryotic-type carbonic anhydrase 0.0283 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0127 PF00105 Zinc finger, C4 type (two domains), SUB665 C-C=C-C=C 0.0616 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0114 PF00105 Zinc finger, C4 type (two domains), 0.0113 PF02159 Oestrogen receptor SUB404 N(:C)(:C) 0.0590 PF00067 Cytochrome P450 SUB652 O-C:C:C-C 0.0553 PF00702 haloacid dehalogenase-like hydrolase SUB741 Oc1cc(O)ccc1 0.0552 PF00478 IMP dehydrogenase / GMP reductase domain 0.0441 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0013 PF00373 FERM central domain SUB363 C(~Cl)(:C) 0.0538 PF00229 TNF(Tumour Necrosis Factor), family 0.0353 PF03630 Fumble 0.0307 PF00194 Eukaryotic-type carbonic anhydrase 0.0001 PF01477 PLAT/LH2 domain SUB371 C(~H)(:C) 0.0522 PF00001 7 transmembrane receptor (rhodopsin family), SUB831 SC1C(N)CCCC1 0.0501 PF00520 Ion transport protein 0.0006 PF06512 Sodium ion transport-associated SUB475 S:C:C:N 0.0462 PF01770 Reduced folate carrier SUB525 C-C=C-C 0.0448 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0010 PF00104 Ligand-binding domain of nuclear hormone receptor SUB596 C:C-C-C-C 0.0413 PF00001 7 transmembrane receptor (rhodopsin family), SUB569 N#C-C-C 0.0409 PF01007 Inward rectifier potassium channel 0.0044 PF00625 Guanylate kinase SUB758 Cc1c(S)cccc1 0.0398 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0003 PF02146 Sir2 family SUB746 Sc1cc(S)ccc1 0.0375 PF00194 Eukaryotic-type carbonic anhydrase 0.0268 PF02146 Sir2 family SUB235 >= 2 any ring size 8 0.0375 PF02180 Bcl-2 homology region 4 SUB701 O-C-C-C-C-C-O-C 0.0353 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0033 PF04711 Apolipoprotein A-II (ApoA-II), 0.0007 PF02932 Neurotransmitter-gated ion-channel transmembrane region SUB599 Cl-C:C:C-C 0.0292 PF00229 TNF(Tumour Necrosis Factor), family 0.0267 PF01477 PLAT/LH2 domain 0.0132 PF00194 Eukaryotic-type carbonic anhydrase SUB601 N-C:C:C-C 0.0290 PF00273 Serum albumin family 0.0083 PF00001 7 transmembrane receptor (rhodopsin family), SUB428 C(#C)(-C) 0.0270 PF00194 Eukaryotic-type carbonic anhydrase SUB148 >= 1 unsaturated non-aromatic carbon-only ring size 5 0.0189 PF00071 Ras family SUB420 C#N 0.0150 PF01007 Inward rectifier potassium channel 0.0073 PF00194 Eukaryotic-type carbonic anhydrase SUB202 >= 4 saturated or aromatic nitrogen-containing ring size 6 0.0150 PF00520 Ion transport protein 0.0002 PF01462 Leucine rich repeat N-terminal domain SUB491 C-C-C=C 0.0138 PF00273 Serum albumin family SUB609 C-C-C-C:C 0.0135 PF00001 7 transmembrane receptor (rhodopsin family), SUB551 Cl-C-C-C 0.0135 PF00069 Protein kinase domain 0.0003 PF03073 TspO/MBR family SUB679 C-C-C=C-C 0.0101 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0062 PF00273 Serum albumin family SUB752 Nc1cc(Br)ccc1 0.0099 PF00001 7 transmembrane receptor (rhodopsin family), SUB358 C(~C)(:C)(:N) 0.0068 PF09027 GTPase binding SUB661 C-C=C-C-C 0.0056 PF00273 Serum albumin family 0.0007 PF00104 Ligand-binding domain of nuclear hormone receptor SUB798 CC1CC(C)CCC1 0.0038 PF02161 Progesterone receptor SUB524 N:C:C-C 0.0035 PF01234 NNMT/PNMT/TEMT family SUB298 C-Br 0.0019 PF00689 Cation transporting ATPase, C-terminus 0.0001 PF00122 E1-E2 ATPase SUB472 S:C:C:C 0.0007 PF00059 Lectin C-type domain SUB487 N-C:N:N 0.0007 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region SUB641 C=C-C-C-C 0.0004 PF00273 Serum albumin family SUB557 C=C-C-C 0.0003 PF00273 Serum albumin family SUB604 C-C:C:C-C 0.0003 PF00209 Sodium:neurotransmitter symporter family SUB790 SC1CCC(Cl)CC1 0.0002 PF00067 Cytochrome P450 SUB826 OC1C(S)CCCC1 0.0001 PF00061 Lipocalin / cytosolic fatty-acid binding protein family SUB175 >= 5 saturated or aromatic heteroatom-containing ring size 5 0.0001 PF00001 7 transmembrane receptor (rhodopsin family), SUB47 >= 1 I 0.0001 PF12605 Casein kinase 1 gamma C terminal