SUB789 SC1CCC(N)CC1 0.5452 PF00194 Eukaryotic-type carbonic anhydrase 0.1939 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1939 PF02254 TrkA-N domain 0.1916 PF08403 Amino acid permease N-terminal 0.0919 PF00324 Amino acid permease 0.0664 PF00689 Cation transporting ATPase, C-terminus 0.0664 PF00690 Cation transporter/ATPase, N-terminus 0.0591 PF00122 E1-E2 ATPase 0.0527 PF00702 haloacid dehalogenase-like hydrolase 0.0371 PF00520 Ion transport protein 0.0341 PF01007 Inward rectifier potassium channel 0.0274 PF02146 Sir2 family 0.0267 PF00102 Protein-tyrosine phosphatase 0.0229 PF02038 ATP1G1/PLM/MAT8 family 0.0210 PF10420 Cytokine interleukin-12p40 C-terminus 0.0196 PF09396 Thrombin light chain 0.0196 PF01916 Deoxyhypusine synthase 0.0185 PF01471 Putative peptidoglycan binding domain 0.0185 PF00045 Hemopexin 0.0171 PF00413 Matrixin 0.0143 PF00108 Thiolase, N-terminal domain 0.0143 PF02803 Thiolase, C-terminal domain 0.0139 PF00040 Fibronectin type II domain 0.0137 PF00001 7 transmembrane receptor (rhodopsin family), 0.0128 PF00043 Glutathione S-transferase, C-terminal domain 0.0122 PF02798 Glutathione S-transferase, N-terminal domain 0.0111 PF00069 Protein kinase domain 0.0107 PF08983 Domain of unknown function (DUF1856), 0.0076 PF00186 Dihydrofolate reductase 0.0075 PF00273 Serum albumin family 0.0075 PF00167 Fibroblast growth factor 0.0072 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0046 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0042 PF11857 Domain of unknown function (DUF3377), 0.0041 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0041 PF08702 Fibrinogen alpha/beta chain family 0.0040 PF00664 ABC transporter transmembrane region 0.0039 PF04679 ATP dependent DNA ligase C terminal region 0.0039 PF01068 ATP dependent DNA ligase domain 0.0035 PF00051 Kringle domain 0.0029 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0029 PF02793 Hormone receptor domain 0.0029 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0029 PF04055 Radical SAM superfamily 0.0029 PF00002 7 transmembrane receptor (Secretin family), 0.0029 PF08833 Axin beta-catenin binding domain 0.0029 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0029 PF03098 Animal haem peroxidase 0.0029 PF00778 DIX domain 0.0025 PF00020 TNFR/NGFR cysteine-rich region 0.0025 PF00005 ABC transporter 0.0024 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0022 PF02060 Slow voltage-gated potassium channel 0.0020 PF01731 Arylesterase 0.0020 PF01369 Sec7 domain 0.0020 PF00265 Thymidine kinase 0.0019 PF00230 Major intrinsic protein 0.0019 PF08466 Inward rectifier potassium channel N-terminal 0.0018 PF12160 Fibrinogen alpha C domain 0.0015 PF03520 KCNQ voltage-gated potassium channel 0.0014 PF03099 Biotin/lipoate A/B protein ligase family 0.0014 PF00024 PAN domain 0.0009 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0008 PF00822 PMP-22/EMP/MP20/Claudin family 0.0008 PF00474 Sodium:solute symporter family 0.0008 PF00615 Regulator of G protein signaling domain 0.0008 PF01462 Leucine rich repeat N-terminal domain 0.0006 PF00357 Integrin alpha cytoplasmic region 0.0006 PF00058 Low-density lipoprotein receptor repeat class B 0.0004 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0004 PF01734 Patatin-like phospholipase 0.0004 PF01234 NNMT/PNMT/TEMT family 0.0004 PF08441 Integrin alpha 0.0003 PF00757 Furin-like cysteine rich region 0.0003 PF01030 Receptor L domain 0.0002 PF02185 Hr1 repeat 0.0002 PF08912 Rho Binding 0.0002 PF01590 GAF domain 0.0002 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0001 PF08447 PAS fold 0.0001 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0001 PF01582 TIR domain 0.0001 PF00042 Globin 0.0001 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF00531 Death domain 0.0001 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0001 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain SUB726 Sc1ccc(N)cc1 0.5452 PF00194 Eukaryotic-type carbonic anhydrase 0.1939 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1939 PF02254 TrkA-N domain 0.1916 PF08403 Amino acid permease N-terminal 0.0919 PF00324 Amino acid permease 0.0664 PF00689 Cation transporting ATPase, C-terminus 0.0664 PF00690 Cation transporter/ATPase, N-terminus 0.0591 PF00122 E1-E2 ATPase 0.0527 PF00702 haloacid dehalogenase-like hydrolase 0.0371 PF00520 Ion transport protein 0.0341 PF01007 Inward rectifier potassium channel 0.0274 PF02146 Sir2 family 0.0267 PF00102 Protein-tyrosine phosphatase 0.0229 PF02038 ATP1G1/PLM/MAT8 family 0.0210 PF10420 Cytokine interleukin-12p40 C-terminus 0.0196 PF09396 Thrombin light chain 0.0196 PF01916 Deoxyhypusine synthase 0.0185 PF00045 Hemopexin 0.0185 PF01471 Putative peptidoglycan binding domain 0.0171 PF00413 Matrixin 0.0143 PF00108 Thiolase, N-terminal domain 0.0143 PF02803 Thiolase, C-terminal domain 0.0139 PF00040 Fibronectin type II domain 0.0137 PF00001 7 transmembrane receptor (rhodopsin family), 0.0128 PF00043 Glutathione S-transferase, C-terminal domain 0.0122 PF02798 Glutathione S-transferase, N-terminal domain 0.0111 PF00069 Protein kinase domain 0.0107 PF08983 Domain of unknown function (DUF1856), 0.0076 PF00186 Dihydrofolate reductase 0.0075 PF00167 Fibroblast growth factor 0.0075 PF00273 Serum albumin family 0.0072 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0046 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0042 PF11857 Domain of unknown function (DUF3377), 0.0041 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0041 PF08702 Fibrinogen alpha/beta chain family 0.0040 PF00664 ABC transporter transmembrane region 0.0039 PF04679 ATP dependent DNA ligase C terminal region 0.0039 PF01068 ATP dependent DNA ligase domain 0.0035 PF00051 Kringle domain 0.0029 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0029 PF08833 Axin beta-catenin binding domain 0.0029 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0029 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0029 PF02793 Hormone receptor domain 0.0029 PF00002 7 transmembrane receptor (Secretin family), 0.0029 PF03098 Animal haem peroxidase 0.0029 PF00778 DIX domain 0.0029 PF04055 Radical SAM superfamily 0.0025 PF00005 ABC transporter 0.0025 PF00020 TNFR/NGFR cysteine-rich region 0.0024 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0022 PF02060 Slow voltage-gated potassium channel 0.0020 PF01731 Arylesterase 0.0020 PF01369 Sec7 domain 0.0020 PF00265 Thymidine kinase 0.0019 PF08466 Inward rectifier potassium channel N-terminal 0.0019 PF00230 Major intrinsic protein 0.0018 PF12160 Fibrinogen alpha C domain 0.0015 PF03520 KCNQ voltage-gated potassium channel 0.0014 PF03099 Biotin/lipoate A/B protein ligase family 0.0014 PF00024 PAN domain 0.0009 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0008 PF00822 PMP-22/EMP/MP20/Claudin family 0.0008 PF01462 Leucine rich repeat N-terminal domain 0.0008 PF00474 Sodium:solute symporter family 0.0008 PF00615 Regulator of G protein signaling domain 0.0006 PF00357 Integrin alpha cytoplasmic region 0.0006 PF00058 Low-density lipoprotein receptor repeat class B 0.0004 PF08441 Integrin alpha 0.0004 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0004 PF01734 Patatin-like phospholipase 0.0004 PF01234 NNMT/PNMT/TEMT family 0.0003 PF00757 Furin-like cysteine rich region 0.0003 PF01030 Receptor L domain 0.0002 PF02185 Hr1 repeat 0.0002 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0002 PF01590 GAF domain 0.0002 PF08912 Rho Binding 0.0001 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0001 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0001 PF00531 Death domain 0.0001 PF01582 TIR domain 0.0001 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF08447 PAS fold 0.0001 PF00042 Globin 0.0001 PF09279 Phosphoinositide-specific phospholipase C, efhand-like SUB275 B-C 0.4945 PF00227 Proteasome subunit 0.0686 PF01048 Phosphorylase superfamily 0.0577 PF00069 Protein kinase domain 0.0551 PF00478 IMP dehydrogenase / GMP reductase domain 0.0513 PF00186 Dihydrofolate reductase 0.0436 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0363 PF00571 CBS domain 0.0359 PF00962 Adenosine/AMP deaminase 0.0299 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0288 PF00156 Phosphoribosyl transferase domain 0.0246 PF08240 Alcohol dehydrogenase GroES-like domain 0.0241 PF00107 Zinc-binding dehydrogenase 0.0238 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0221 PF01590 GAF domain 0.0221 PF00106 short chain dehydrogenase 0.0202 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0202 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0183 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0183 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0183 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0182 PF00858 Amiloride-sensitive sodium channel 0.0155 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0151 PF00017 SH2 domain 0.0145 PF00171 Aldehyde dehydrogenase family 0.0138 PF00018 SH3 domain 0.0135 PF01467 Cytidylyltransferase 0.0131 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0131 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0112 PF00501 AMP-binding enzyme 0.0108 PF01122 Eukaryotic cobalamin-binding protein 0.0107 PF08919 F-actin binding 0.0098 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0098 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0094 PF10397 Adenylosuccinate lyase C-terminus 0.0094 PF00136 DNA polymerase family B 0.0094 PF03104 DNA polymerase family B, exonuclease domain 0.0094 PF08996 DNA Polymerase alpha zinc finger 0.0093 PF12423 Kinesin protein 1B 0.0093 PF01119 DNA mismatch repair protein, C-terminal domain 0.0093 PF12473 Kinesin protein 0.0093 PF00498 FHA domain 0.0093 PF08676 MutL C terminal dimerisation domain 0.0093 PF01126 Heme oxygenase 0.0092 PF00970 Oxidoreductase FAD-binding domain 0.0092 PF01575 MaoC like domain 0.0092 PF01652 Eukaryotic initiation factor 4E 0.0092 PF02036 SCP-2 sterol transfer family 0.0090 PF00821 Phosphoenolpyruvate carboxykinase 0.0086 PF01230 HIT domain 0.0083 PF02223 Thymidylate kinase 0.0081 PF00225 Kinesin motor domain 0.0078 PF01808 AICARFT/IMPCHase bienzyme 0.0076 PF07966 A1 Propeptide 0.0076 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0076 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0076 PF00931 NB-ARC domain 0.0076 PF00400 WD domain, G-beta repeat 0.0075 PF02233 NAD(P), transhydrogenase beta subunit 0.0074 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0074 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0073 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0073 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0073 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0071 PF00689 Cation transporting ATPase, C-terminus 0.0071 PF00690 Cation transporter/ATPase, N-terminus 0.0070 PF00071 Ras family 0.0066 PF02525 Flavodoxin-like fold 0.0065 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0064 PF01064 Activin types I and II receptor domain 0.0064 PF08515 Transforming growth factor beta type I GS-motif 0.0064 PF00378 Enoyl-CoA hydratase/isomerase family 0.0063 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0063 PF00676 Dehydrogenase E1 component 0.0063 PF00702 haloacid dehalogenase-like hydrolase 0.0061 PF00317 Ribonucleotide reductase, all-alpha domain 0.0061 PF03477 ATP cone domain 0.0061 PF02867 Ribonucleotide reductase, barrel domain 0.0060 PF03308 ArgK protein 0.0060 PF01923 Cobalamin adenosyltransferase 0.0060 PF03949 Malic enzyme, NAD binding domain 0.0060 PF01642 Methylmalonyl-CoA mutase 0.0060 PF00390 Malic enzyme, N-terminal domain 0.0059 PF00958 GMP synthase C terminal domain 0.0058 PF03770 Inositol polyphosphate kinase 0.0053 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0052 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0052 PF03073 TspO/MBR family 0.0051 PF00310 Glutamine amidotransferases class-II 0.0049 PF00248 Aldo/keto reductase family 0.0045 PF00122 E1-E2 ATPase 0.0044 PF09027 GTPase binding 0.0044 PF02267 ADP-ribosyl cyclase 0.0044 PF11555 EGFR receptor inhibitor Mig-6 0.0043 PF00536 SAM domain (Sterile alpha motif), 0.0043 PF01404 Ephrin receptor ligand binding domain 0.0042 PF01068 ATP dependent DNA ligase domain 0.0042 PF00334 Nucleoside diphosphate kinase 0.0042 PF03024 Folate receptor family 0.0042 PF04679 ATP dependent DNA ligase C terminal region 0.0042 PF00025 ADP-ribosylation factor family 0.0041 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0041 PF05347 Complex 1 protein (LYR family), 0.0041 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0041 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0040 PF02310 B12 binding domain 0.0034 PF00757 Furin-like cysteine rich region 0.0034 PF01030 Receptor L domain 0.0032 PF00042 Globin 0.0031 PF00206 Lyase 0.0031 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0031 PF01712 Deoxynucleoside kinase 0.0029 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0029 PF02779 Transketolase, pyrimidine binding domain 0.0029 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0029 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0029 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0029 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0029 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0028 PF01268 Formate--tetrahydrofolate ligase 0.0028 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0027 PF00533 BRCA1 C Terminus (BRCT), domain 0.0027 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0027 PF05406 WGR domain 0.0027 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0027 PF08063 PADR1 (NUC008), domain 0.0026 PF01916 Deoxyhypusine synthase 0.0024 PF00005 ABC transporter 0.0023 PF03530 Calcium-activated SK potassium channel 0.0023 PF02888 Calmodulin binding domain 0.0021 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0021 PF00794 PI3-kinase family, ras-binding domain 0.0021 PF00792 Phosphoinositide 3-kinase C2 0.0018 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0018 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0018 PF00026 Eukaryotic aspartyl protease 0.0018 PF02772 S-adenosylmethionine synthetase, central domain 0.0016 PF00183 Hsp90 protein 0.0013 PF00629 MAM domain 0.0013 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0013 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0013 PF01835 MG2 domain 0.0013 PF10509 Galactokinase galactose-binding signature 0.0013 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0013 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0013 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0013 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0013 PF00384 Molybdopterin oxidoreductase 0.0013 PF10531 SLBB domain 0.0013 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0013 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0013 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0013 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0013 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0013 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0013 PF00300 Phosphoglycerate mutase family 0.0013 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0013 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0013 PF01370 NAD dependent epimerase/dehydratase family 0.0013 PF00287 Sodium / potassium ATPase beta chain 0.0013 PF00288 GHMP kinases N terminal domain 0.0013 PF02817 e3 binding domain 0.0013 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0013 PF00004 ATPase family associated with various cellular activities (AAA), 0.0013 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0013 PF04116 Fatty acid hydroxylase superfamily 0.0013 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0013 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0013 PF02466 Tim17/Tim22/Tim23 family 0.0013 PF10276 Zinc-finger domain 0.0013 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0013 PF00221 Phenylalanine and histidine ammonia-lyase 0.0013 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0013 PF02493 MORN repeat 0.0013 PF12062 heparan sulfate-N-deacetylase 0.0013 PF08040 MNLL subunit 0.0013 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0013 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0013 PF01434 Peptidase family M41 0.0013 PF07677 A-macroglobulin receptor 0.0013 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0013 PF07678 A-macroglobulin complement component 0.0013 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0013 PF00856 SET domain 0.0013 PF04800 ETC complex I subunit conserved region 0.0013 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0013 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0013 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0013 PF01583 Adenylylsulphate kinase 0.0013 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0013 PF09326 Domain of unknown function (DUF1982), 0.0013 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0013 PF00316 Fructose-1-6-bisphosphatase 0.0013 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0013 PF06212 GRIM-19 protein 0.0013 PF04716 ETC complex I subunit conserved region 0.0013 PF00899 ThiF family 0.0013 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0013 PF08544 GHMP kinases C terminal 0.0013 PF01591 6-phosphofructo-2-kinase 0.0013 PF00439 Bromodomain 0.0013 PF00012 Hsp70 protein 0.0013 PF02037 SAP domain 0.0013 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0013 PF09166 Biliverdin reductase, catalytic 0.0013 PF01747 ATP-sulfurylase 0.0011 PF02173 pKID domain 0.0011 PF01687 Riboflavin kinase 0.0008 PF00002 7 transmembrane receptor (Secretin family), 0.0008 PF00615 Regulator of G protein signaling domain 0.0008 PF02793 Hormone receptor domain 0.0007 PF01582 TIR domain 0.0007 PF00291 Pyridoxal-phosphate dependent enzyme 0.0007 PF02196 Raf-like Ras-binding domain 0.0007 PF00343 Carbohydrate phosphorylase 0.0006 PF02142 MGS-like domain 0.0006 PF02803 Thiolase, C-terminal domain 0.0006 PF01017 STAT protein, all-alpha domain 0.0006 PF02864 STAT protein, DNA binding domain 0.0006 PF02865 STAT protein, protein interaction domain 0.0006 PF00108 Thiolase, N-terminal domain 0.0005 PF00349 Hexokinase 0.0005 PF00619 Caspase recruitment domain 0.0005 PF03727 Hexokinase 0.0003 PF01061 ABC-2 type transporter 0.0001 PF01437 Plexin repeat 0.0001 PF01403 Sema domain 0.0001 PF01833 IPT/TIG domain SUB7 >= 1 B 0.4945 PF00227 Proteasome subunit 0.0686 PF01048 Phosphorylase superfamily 0.0577 PF00069 Protein kinase domain 0.0551 PF00478 IMP dehydrogenase / GMP reductase domain 0.0513 PF00186 Dihydrofolate reductase 0.0436 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0363 PF00571 CBS domain 0.0359 PF00962 Adenosine/AMP deaminase 0.0299 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0288 PF00156 Phosphoribosyl transferase domain 0.0246 PF08240 Alcohol dehydrogenase GroES-like domain 0.0241 PF00107 Zinc-binding dehydrogenase 0.0238 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0221 PF01590 GAF domain 0.0221 PF00106 short chain dehydrogenase 0.0202 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0202 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0183 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0183 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0183 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0182 PF00858 Amiloride-sensitive sodium channel 0.0155 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0151 PF00017 SH2 domain 0.0145 PF00171 Aldehyde dehydrogenase family 0.0138 PF00018 SH3 domain 0.0135 PF01467 Cytidylyltransferase 0.0131 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0131 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0112 PF00501 AMP-binding enzyme 0.0108 PF01122 Eukaryotic cobalamin-binding protein 0.0107 PF08919 F-actin binding 0.0098 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0098 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0094 PF10397 Adenylosuccinate lyase C-terminus 0.0094 PF03104 DNA polymerase family B, exonuclease domain 0.0094 PF00136 DNA polymerase family B 0.0094 PF08996 DNA Polymerase alpha zinc finger 0.0093 PF12473 Kinesin protein 0.0093 PF12423 Kinesin protein 1B 0.0093 PF01126 Heme oxygenase 0.0093 PF00498 FHA domain 0.0093 PF01119 DNA mismatch repair protein, C-terminal domain 0.0093 PF08676 MutL C terminal dimerisation domain 0.0092 PF00970 Oxidoreductase FAD-binding domain 0.0092 PF01652 Eukaryotic initiation factor 4E 0.0092 PF02036 SCP-2 sterol transfer family 0.0092 PF01575 MaoC like domain 0.0090 PF00821 Phosphoenolpyruvate carboxykinase 0.0086 PF01230 HIT domain 0.0083 PF02223 Thymidylate kinase 0.0081 PF00225 Kinesin motor domain 0.0078 PF01808 AICARFT/IMPCHase bienzyme 0.0076 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0076 PF00931 NB-ARC domain 0.0076 PF00400 WD domain, G-beta repeat 0.0076 PF07966 A1 Propeptide 0.0076 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0075 PF02233 NAD(P), transhydrogenase beta subunit 0.0074 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0074 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0073 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0073 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0073 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0071 PF00690 Cation transporter/ATPase, N-terminus 0.0071 PF00689 Cation transporting ATPase, C-terminus 0.0070 PF00071 Ras family 0.0066 PF02525 Flavodoxin-like fold 0.0065 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0064 PF00378 Enoyl-CoA hydratase/isomerase family 0.0064 PF01064 Activin types I and II receptor domain 0.0064 PF08515 Transforming growth factor beta type I GS-motif 0.0063 PF00676 Dehydrogenase E1 component 0.0063 PF00702 haloacid dehalogenase-like hydrolase 0.0063 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0061 PF02867 Ribonucleotide reductase, barrel domain 0.0061 PF03477 ATP cone domain 0.0061 PF00317 Ribonucleotide reductase, all-alpha domain 0.0060 PF01923 Cobalamin adenosyltransferase 0.0060 PF03949 Malic enzyme, NAD binding domain 0.0060 PF03308 ArgK protein 0.0060 PF00390 Malic enzyme, N-terminal domain 0.0060 PF01642 Methylmalonyl-CoA mutase 0.0059 PF00958 GMP synthase C terminal domain 0.0058 PF03770 Inositol polyphosphate kinase 0.0053 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0052 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0052 PF03073 TspO/MBR family 0.0051 PF00310 Glutamine amidotransferases class-II 0.0049 PF00248 Aldo/keto reductase family 0.0045 PF00122 E1-E2 ATPase 0.0044 PF02267 ADP-ribosyl cyclase 0.0044 PF09027 GTPase binding 0.0044 PF11555 EGFR receptor inhibitor Mig-6 0.0043 PF01404 Ephrin receptor ligand binding domain 0.0043 PF00536 SAM domain (Sterile alpha motif), 0.0042 PF00334 Nucleoside diphosphate kinase 0.0042 PF03024 Folate receptor family 0.0042 PF04679 ATP dependent DNA ligase C terminal region 0.0042 PF01068 ATP dependent DNA ligase domain 0.0042 PF00025 ADP-ribosylation factor family 0.0041 PF05347 Complex 1 protein (LYR family), 0.0041 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0041 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0041 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0040 PF02310 B12 binding domain 0.0034 PF00757 Furin-like cysteine rich region 0.0034 PF01030 Receptor L domain 0.0032 PF00042 Globin 0.0031 PF00206 Lyase 0.0031 PF01712 Deoxynucleoside kinase 0.0031 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0029 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0029 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0029 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0029 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0029 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0029 PF02779 Transketolase, pyrimidine binding domain 0.0029 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0028 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0028 PF01268 Formate--tetrahydrofolate ligase 0.0027 PF00533 BRCA1 C Terminus (BRCT), domain 0.0027 PF08063 PADR1 (NUC008), domain 0.0027 PF05406 WGR domain 0.0027 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0027 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0026 PF01916 Deoxyhypusine synthase 0.0024 PF00005 ABC transporter 0.0023 PF02888 Calmodulin binding domain 0.0023 PF03530 Calcium-activated SK potassium channel 0.0021 PF00794 PI3-kinase family, ras-binding domain 0.0021 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0021 PF00792 Phosphoinositide 3-kinase C2 0.0018 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0018 PF02772 S-adenosylmethionine synthetase, central domain 0.0018 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0018 PF00026 Eukaryotic aspartyl protease 0.0016 PF00183 Hsp90 protein 0.0013 PF00629 MAM domain 0.0013 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0013 PF10531 SLBB domain 0.0013 PF01370 NAD dependent epimerase/dehydratase family 0.0013 PF02493 MORN repeat 0.0013 PF00316 Fructose-1-6-bisphosphatase 0.0013 PF00899 ThiF family 0.0013 PF00288 GHMP kinases N terminal domain 0.0013 PF09326 Domain of unknown function (DUF1982), 0.0013 PF00287 Sodium / potassium ATPase beta chain 0.0013 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0013 PF12062 heparan sulfate-N-deacetylase 0.0013 PF02037 SAP domain 0.0013 PF08544 GHMP kinases C terminal 0.0013 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0013 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0013 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0013 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0013 PF00300 Phosphoglycerate mutase family 0.0013 PF04116 Fatty acid hydroxylase superfamily 0.0013 PF08040 MNLL subunit 0.0013 PF01747 ATP-sulfurylase 0.0013 PF01591 6-phosphofructo-2-kinase 0.0013 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0013 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0013 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0013 PF04800 ETC complex I subunit conserved region 0.0013 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0013 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0013 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0013 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0013 PF10276 Zinc-finger domain 0.0013 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0013 PF09166 Biliverdin reductase, catalytic 0.0013 PF01583 Adenylylsulphate kinase 0.0013 PF02466 Tim17/Tim22/Tim23 family 0.0013 PF00856 SET domain 0.0013 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0013 PF02817 e3 binding domain 0.0013 PF00439 Bromodomain 0.0013 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0013 PF00384 Molybdopterin oxidoreductase 0.0013 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0013 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0013 PF00221 Phenylalanine and histidine ammonia-lyase 0.0013 PF04716 ETC complex I subunit conserved region 0.0013 PF10509 Galactokinase galactose-binding signature 0.0013 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0013 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0013 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0013 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0013 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0013 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0013 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0013 PF06212 GRIM-19 protein 0.0013 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0013 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0013 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0013 PF01434 Peptidase family M41 0.0013 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0013 PF01835 MG2 domain 0.0013 PF00004 ATPase family associated with various cellular activities (AAA), 0.0013 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0013 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0013 PF00012 Hsp70 protein 0.0013 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0013 PF07677 A-macroglobulin receptor 0.0013 PF07678 A-macroglobulin complement component 0.0011 PF01687 Riboflavin kinase 0.0011 PF02173 pKID domain 0.0008 PF02793 Hormone receptor domain 0.0008 PF00615 Regulator of G protein signaling domain 0.0008 PF00002 7 transmembrane receptor (Secretin family), 0.0007 PF00343 Carbohydrate phosphorylase 0.0007 PF01582 TIR domain 0.0007 PF00291 Pyridoxal-phosphate dependent enzyme 0.0007 PF02196 Raf-like Ras-binding domain 0.0006 PF02865 STAT protein, protein interaction domain 0.0006 PF02864 STAT protein, DNA binding domain 0.0006 PF01017 STAT protein, all-alpha domain 0.0006 PF00108 Thiolase, N-terminal domain 0.0006 PF02803 Thiolase, C-terminal domain 0.0006 PF02142 MGS-like domain 0.0005 PF00349 Hexokinase 0.0005 PF00619 Caspase recruitment domain 0.0005 PF03727 Hexokinase 0.0003 PF01061 ABC-2 type transporter 0.0001 PF01403 Sema domain 0.0001 PF01437 Plexin repeat 0.0001 PF01833 IPT/TIG domain SUB277 B-O 0.4945 PF00227 Proteasome subunit 0.0686 PF01048 Phosphorylase superfamily 0.0577 PF00069 Protein kinase domain 0.0551 PF00478 IMP dehydrogenase / GMP reductase domain 0.0513 PF00186 Dihydrofolate reductase 0.0436 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0363 PF00571 CBS domain 0.0359 PF00962 Adenosine/AMP deaminase 0.0299 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0288 PF00156 Phosphoribosyl transferase domain 0.0246 PF08240 Alcohol dehydrogenase GroES-like domain 0.0241 PF00107 Zinc-binding dehydrogenase 0.0238 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0221 PF01590 GAF domain 0.0221 PF00106 short chain dehydrogenase 0.0202 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0202 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0183 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0183 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0183 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0182 PF00858 Amiloride-sensitive sodium channel 0.0155 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0151 PF00017 SH2 domain 0.0145 PF00171 Aldehyde dehydrogenase family 0.0138 PF00018 SH3 domain 0.0135 PF01467 Cytidylyltransferase 0.0131 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0131 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0112 PF00501 AMP-binding enzyme 0.0108 PF01122 Eukaryotic cobalamin-binding protein 0.0107 PF08919 F-actin binding 0.0098 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0098 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0094 PF00136 DNA polymerase family B 0.0094 PF03104 DNA polymerase family B, exonuclease domain 0.0094 PF08996 DNA Polymerase alpha zinc finger 0.0094 PF10397 Adenylosuccinate lyase C-terminus 0.0093 PF08676 MutL C terminal dimerisation domain 0.0093 PF12473 Kinesin protein 0.0093 PF00498 FHA domain 0.0093 PF12423 Kinesin protein 1B 0.0093 PF01126 Heme oxygenase 0.0093 PF01119 DNA mismatch repair protein, C-terminal domain 0.0092 PF02036 SCP-2 sterol transfer family 0.0092 PF01652 Eukaryotic initiation factor 4E 0.0092 PF00970 Oxidoreductase FAD-binding domain 0.0092 PF01575 MaoC like domain 0.0090 PF00821 Phosphoenolpyruvate carboxykinase 0.0086 PF01230 HIT domain 0.0083 PF02223 Thymidylate kinase 0.0081 PF00225 Kinesin motor domain 0.0078 PF01808 AICARFT/IMPCHase bienzyme 0.0076 PF07966 A1 Propeptide 0.0076 PF00931 NB-ARC domain 0.0076 PF00400 WD domain, G-beta repeat 0.0076 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0076 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0075 PF02233 NAD(P), transhydrogenase beta subunit 0.0074 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0074 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0073 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0073 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0073 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0071 PF00689 Cation transporting ATPase, C-terminus 0.0071 PF00690 Cation transporter/ATPase, N-terminus 0.0070 PF00071 Ras family 0.0066 PF02525 Flavodoxin-like fold 0.0065 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0064 PF01064 Activin types I and II receptor domain 0.0064 PF00378 Enoyl-CoA hydratase/isomerase family 0.0064 PF08515 Transforming growth factor beta type I GS-motif 0.0063 PF00676 Dehydrogenase E1 component 0.0063 PF00702 haloacid dehalogenase-like hydrolase 0.0063 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0061 PF03477 ATP cone domain 0.0061 PF02867 Ribonucleotide reductase, barrel domain 0.0061 PF00317 Ribonucleotide reductase, all-alpha domain 0.0060 PF03308 ArgK protein 0.0060 PF01923 Cobalamin adenosyltransferase 0.0060 PF00390 Malic enzyme, N-terminal domain 0.0060 PF01642 Methylmalonyl-CoA mutase 0.0060 PF03949 Malic enzyme, NAD binding domain 0.0059 PF00958 GMP synthase C terminal domain 0.0058 PF03770 Inositol polyphosphate kinase 0.0053 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0052 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0052 PF03073 TspO/MBR family 0.0051 PF00310 Glutamine amidotransferases class-II 0.0049 PF00248 Aldo/keto reductase family 0.0045 PF00122 E1-E2 ATPase 0.0044 PF09027 GTPase binding 0.0044 PF11555 EGFR receptor inhibitor Mig-6 0.0044 PF02267 ADP-ribosyl cyclase 0.0043 PF00536 SAM domain (Sterile alpha motif), 0.0043 PF01404 Ephrin receptor ligand binding domain 0.0042 PF00334 Nucleoside diphosphate kinase 0.0042 PF03024 Folate receptor family 0.0042 PF00025 ADP-ribosylation factor family 0.0042 PF04679 ATP dependent DNA ligase C terminal region 0.0042 PF01068 ATP dependent DNA ligase domain 0.0041 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0041 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0041 PF05347 Complex 1 protein (LYR family), 0.0041 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0040 PF02310 B12 binding domain 0.0034 PF01030 Receptor L domain 0.0034 PF00757 Furin-like cysteine rich region 0.0032 PF00042 Globin 0.0031 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0031 PF01712 Deoxynucleoside kinase 0.0031 PF00206 Lyase 0.0029 PF02779 Transketolase, pyrimidine binding domain 0.0029 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0029 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0029 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0029 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0029 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0029 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0028 PF01268 Formate--tetrahydrofolate ligase 0.0028 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0027 PF00533 BRCA1 C Terminus (BRCT), domain 0.0027 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0027 PF08063 PADR1 (NUC008), domain 0.0027 PF05406 WGR domain 0.0027 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0026 PF01916 Deoxyhypusine synthase 0.0024 PF00005 ABC transporter 0.0023 PF02888 Calmodulin binding domain 0.0023 PF03530 Calcium-activated SK potassium channel 0.0021 PF00794 PI3-kinase family, ras-binding domain 0.0021 PF00792 Phosphoinositide 3-kinase C2 0.0021 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0018 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0018 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0018 PF00026 Eukaryotic aspartyl protease 0.0018 PF02772 S-adenosylmethionine synthetase, central domain 0.0016 PF00183 Hsp90 protein 0.0013 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0013 PF02817 e3 binding domain 0.0013 PF01583 Adenylylsulphate kinase 0.0013 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0013 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0013 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0013 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0013 PF12062 heparan sulfate-N-deacetylase 0.0013 PF00629 MAM domain 0.0013 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0013 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0013 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0013 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0013 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0013 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0013 PF00384 Molybdopterin oxidoreductase 0.0013 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0013 PF00439 Bromodomain 0.0013 PF01747 ATP-sulfurylase 0.0013 PF00316 Fructose-1-6-bisphosphatase 0.0013 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0013 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0013 PF00300 Phosphoglycerate mutase family 0.0013 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0013 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0013 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0013 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0013 PF06212 GRIM-19 protein 0.0013 PF01370 NAD dependent epimerase/dehydratase family 0.0013 PF04800 ETC complex I subunit conserved region 0.0013 PF02466 Tim17/Tim22/Tim23 family 0.0013 PF09166 Biliverdin reductase, catalytic 0.0013 PF00899 ThiF family 0.0013 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0013 PF04116 Fatty acid hydroxylase superfamily 0.0013 PF10276 Zinc-finger domain 0.0013 PF07678 A-macroglobulin complement component 0.0013 PF00221 Phenylalanine and histidine ammonia-lyase 0.0013 PF07677 A-macroglobulin receptor 0.0013 PF00012 Hsp70 protein 0.0013 PF01434 Peptidase family M41 0.0013 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0013 PF00004 ATPase family associated with various cellular activities (AAA), 0.0013 PF01591 6-phosphofructo-2-kinase 0.0013 PF08040 MNLL subunit 0.0013 PF08544 GHMP kinases C terminal 0.0013 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0013 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0013 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0013 PF10531 SLBB domain 0.0013 PF10509 Galactokinase galactose-binding signature 0.0013 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0013 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0013 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0013 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0013 PF09326 Domain of unknown function (DUF1982), 0.0013 PF00287 Sodium / potassium ATPase beta chain 0.0013 PF02037 SAP domain 0.0013 PF00288 GHMP kinases N terminal domain 0.0013 PF01835 MG2 domain 0.0013 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0013 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0013 PF02493 MORN repeat 0.0013 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0013 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0013 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0013 PF00856 SET domain 0.0013 PF04716 ETC complex I subunit conserved region 0.0011 PF01687 Riboflavin kinase 0.0011 PF02173 pKID domain 0.0008 PF02793 Hormone receptor domain 0.0008 PF00002 7 transmembrane receptor (Secretin family), 0.0008 PF00615 Regulator of G protein signaling domain 0.0007 PF02196 Raf-like Ras-binding domain 0.0007 PF00291 Pyridoxal-phosphate dependent enzyme 0.0007 PF00343 Carbohydrate phosphorylase 0.0007 PF01582 TIR domain 0.0006 PF01017 STAT protein, all-alpha domain 0.0006 PF02803 Thiolase, C-terminal domain 0.0006 PF02142 MGS-like domain 0.0006 PF02864 STAT protein, DNA binding domain 0.0006 PF00108 Thiolase, N-terminal domain 0.0006 PF02865 STAT protein, protein interaction domain 0.0005 PF03727 Hexokinase 0.0005 PF00349 Hexokinase 0.0005 PF00619 Caspase recruitment domain 0.0003 PF01061 ABC-2 type transporter 0.0001 PF01403 Sema domain 0.0001 PF01833 IPT/TIG domain 0.0001 PF01437 Plexin repeat SUB707 O=C-C-C-C-C(=O)-C 0.4598 PF00091 Tubulin/FtsZ family, GTPase domain 0.4598 PF03953 Tubulin C-terminal domain 0.0665 PF07884 Vitamin K epoxide reductase family 0.0612 PF00018 SH3 domain 0.0540 PF00017 SH2 domain 0.0533 PF01068 ATP dependent DNA ligase domain 0.0533 PF04679 ATP dependent DNA ligase C terminal region 0.0526 PF01770 Reduced folate carrier 0.0512 PF08919 F-actin binding 0.0462 PF00102 Protein-tyrosine phosphatase 0.0434 PF00194 Eukaryotic-type carbonic anhydrase 0.0373 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0363 PF00536 SAM domain (Sterile alpha motif), 0.0363 PF01404 Ephrin receptor ligand binding domain 0.0291 PF00854 POT family 0.0250 PF00478 IMP dehydrogenase / GMP reductase domain 0.0250 PF01017 STAT protein, all-alpha domain 0.0250 PF02864 STAT protein, DNA binding domain 0.0250 PF02865 STAT protein, protein interaction domain 0.0237 PF00183 Hsp90 protein 0.0237 PF00656 Caspase domain 0.0234 PF02059 Interleukin-3 0.0234 PF00377 Prion/Doppel alpha-helical domain 0.0231 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0225 PF02394 Interleukin-1 propeptide 0.0225 PF00340 Interleukin-1 / 18 0.0205 PF00962 Adenosine/AMP deaminase 0.0166 PF01023 S-100/ICaBP type calcium binding domain 0.0160 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0159 PF00156 Phosphoribosyl transferase domain 0.0151 PF00069 Protein kinase domain 0.0150 PF10397 Adenylosuccinate lyase C-terminus 0.0149 PF03098 Animal haem peroxidase 0.0148 PF00020 TNFR/NGFR cysteine-rich region 0.0132 PF00619 Caspase recruitment domain 0.0132 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0131 PF00958 GMP synthase C terminal domain 0.0125 PF00341 Platelet-derived growth factor (PDGF), 0.0124 PF02525 Flavodoxin-like fold 0.0112 PF00305 Lipoxygenase 0.0108 PF09396 Thrombin light chain 0.0104 PF00040 Fibronectin type II domain 0.0101 PF00041 Fibronectin type III domain 0.0100 PF12497 Estrogen receptor beta 0.0094 PF00531 Death domain 0.0093 PF00206 Lyase 0.0086 PF02155 Glucocorticoid receptor 0.0078 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0059 PF00001 7 transmembrane receptor (rhodopsin family), 0.0052 PF00273 Serum albumin family 0.0048 PF00709 Adenylosuccinate synthetase 0.0048 PF00117 Glutamine amidotransferase class-I 0.0047 PF01477 PLAT/LH2 domain 0.0039 PF00245 Alkaline phosphatase 0.0039 PF00310 Glutamine amidotransferases class-II 0.0039 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0038 PF00230 Major intrinsic protein 0.0037 PF00571 CBS domain 0.0032 PF01425 Amidase 0.0030 PF02254 TrkA-N domain 0.0030 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0027 PF00690 Cation transporter/ATPase, N-terminus 0.0027 PF00287 Sodium / potassium ATPase beta chain 0.0027 PF00689 Cation transporting ATPase, C-terminus 0.0023 PF07677 A-macroglobulin receptor 0.0023 PF07678 A-macroglobulin complement component 0.0023 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0023 PF01835 MG2 domain 0.0022 PF01731 Arylesterase 0.0017 PF00122 E1-E2 ATPase 0.0006 PF11857 Domain of unknown function (DUF3377), 0.0004 PF08403 Amino acid permease N-terminal 0.0003 PF05193 Peptidase M16 inactive domain 0.0003 PF02038 ATP1G1/PLM/MAT8 family 0.0003 PF00675 Insulinase (Peptidase family M16), 0.0003 PF00557 Metallopeptidase family M24 SUB194 >= 3 saturated or aromatic carbon-only ring size 6 0.4408 PF02159 Oestrogen receptor 0.2327 PF00001 7 transmembrane receptor (rhodopsin family), 0.1908 PF00105 Zinc finger, C4 type (two domains), 0.1860 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1779 PF00204 DNA gyrase B 0.1779 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1779 PF08070 DTHCT (NUC029), region 0.0889 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0863 PF12497 Estrogen receptor beta 0.0861 PF00576 HIUase/Transthyretin family 0.0693 PF08384 Pro-opiomelanocortin, N-terminal region 0.0693 PF00976 Corticotropin ACTH domain 0.0693 PF08035 Opioids neuropeptide 0.0662 PF00102 Protein-tyrosine phosphatase 0.0649 PF00989 PAS fold 0.0642 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0529 PF00027 Cyclic nucleotide-binding domain 0.0517 PF00005 ABC transporter 0.0510 PF00664 ABC transporter transmembrane region 0.0433 PF11825 Protein of unknown function (DUF3345), 0.0363 PF00643 B-box zinc finger 0.0335 PF01596 O-methyltransferase 0.0247 PF01477 PLAT/LH2 domain 0.0242 PF00305 Lipoxygenase 0.0231 PF00340 Interleukin-1 / 18 0.0231 PF03062 MBOAT family 0.0231 PF02394 Interleukin-1 propeptide 0.0194 PF08983 Domain of unknown function (DUF1856), 0.0138 PF04622 ERG2 and Sigma1 receptor like protein 0.0123 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0123 PF00656 Caspase domain 0.0120 PF00183 Hsp90 protein 0.0119 PF00918 Gastrin/cholecystokinin family 0.0119 PF01160 Vertebrate endogenous opioids neuropeptide 0.0082 PF01180 Dihydroorotate dehydrogenase 0.0082 PF01588 Putative tRNA binding domain 0.0078 PF00135 Carboxylesterase 0.0076 PF08377 MAP2/Tau projection domain 0.0076 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0076 PF00650 CRAL/TRIO domain 0.0076 PF03765 CRAL/TRIO, N-terminus 0.0075 PF02180 Bcl-2 homology region 4 0.0075 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0072 PF00377 Prion/Doppel alpha-helical domain 0.0072 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0072 PF02460 Patched family 0.0068 PF08441 Integrin alpha 0.0068 PF00884 Sulfatase 0.0068 PF06327 Domain of Unknown Function (DUF1053), 0.0062 PF00625 Guanylate kinase 0.0058 PF00357 Integrin alpha cytoplasmic region 0.0057 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0045 PF07885 Ion channel 0.0044 PF09396 Thrombin light chain 0.0037 PF00229 TNF(Tumour Necrosis Factor), family 0.0034 PF00341 Platelet-derived growth factor (PDGF), 0.0032 PF02793 Hormone receptor domain 0.0032 PF00002 7 transmembrane receptor (Secretin family), 0.0030 PF08763 Voltage gated calcium channel IQ domain 0.0028 PF02025 Interleukin 5 0.0028 PF00094 von Willebrand factor type D domain 0.0028 PF02201 SWIB/MDM2 domain 0.0028 PF09193 Cholecystokinin A receptor, N-terminal 0.0028 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0028 PF00641 Zn-finger in Ran binding protein and others 0.0028 PF08742 C8 domain 0.0026 PF00170 bZIP transcription factor 0.0024 PF00068 Phospholipase A2 0.0021 PF03953 Tubulin C-terminal domain 0.0021 PF00091 Tubulin/FtsZ family, GTPase domain 0.0020 PF01030 Receptor L domain 0.0020 PF00757 Furin-like cysteine rich region 0.0019 PF00266 Aminotransferase class-V 0.0017 PF02173 pKID domain 0.0017 PF00620 RhoGAP domain 0.0017 PF01733 Nucleoside transporter 0.0014 PF01347 Lipoprotein amino terminal region 0.0009 PF00151 Lipase SUB34 >= 1 S 0.4367 PF00194 Eukaryotic-type carbonic anhydrase 0.1018 PF08403 Amino acid permease N-terminal 0.0625 PF00091 Tubulin/FtsZ family, GTPase domain 0.0625 PF03953 Tubulin C-terminal domain 0.0601 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0601 PF02254 TrkA-N domain 0.0545 PF00045 Hemopexin 0.0545 PF01471 Putative peptidoglycan binding domain 0.0500 PF00413 Matrixin 0.0491 PF01007 Inward rectifier potassium channel 0.0468 PF00324 Amino acid permease 0.0457 PF00001 7 transmembrane receptor (rhodopsin family), 0.0428 PF02798 Glutathione S-transferase, N-terminal domain 0.0425 PF00043 Glutathione S-transferase, C-terminal domain 0.0398 PF00102 Protein-tyrosine phosphatase 0.0284 PF00689 Cation transporting ATPase, C-terminus 0.0284 PF00690 Cation transporter/ATPase, N-terminus 0.0263 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0239 PF00122 E1-E2 ATPase 0.0223 PF01590 GAF domain 0.0198 PF00664 ABC transporter transmembrane region 0.0181 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0176 PF00702 haloacid dehalogenase-like hydrolase 0.0173 PF08983 Domain of unknown function (DUF1856), 0.0165 PF00005 ABC transporter 0.0163 PF00156 Phosphoribosyl transferase domain 0.0148 PF00478 IMP dehydrogenase / GMP reductase domain 0.0148 PF00255 Glutathione peroxidase 0.0148 PF00854 POT family 0.0140 PF09396 Thrombin light chain 0.0136 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0134 PF01770 Reduced folate carrier 0.0133 PF00962 Adenosine/AMP deaminase 0.0121 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0121 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0114 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0114 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0114 PF02772 S-adenosylmethionine synthetase, central domain 0.0110 PF03098 Animal haem peroxidase 0.0105 PF10397 Adenylosuccinate lyase C-terminus 0.0099 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0099 PF04679 ATP dependent DNA ligase C terminal region 0.0099 PF01068 ATP dependent DNA ligase domain 0.0078 PF12497 Estrogen receptor beta 0.0074 PF02785 Biotin carboxylase C-terminal domain 0.0074 PF00108 Thiolase, N-terminal domain 0.0074 PF11857 Domain of unknown function (DUF3377), 0.0074 PF02803 Thiolase, C-terminal domain 0.0069 PF01124 MAPEG family 0.0067 PF00656 Caspase domain 0.0065 PF08441 Integrin alpha 0.0065 PF08912 Rho Binding 0.0065 PF02185 Hr1 repeat 0.0063 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0061 PF04321 RmlD substrate binding domain 0.0061 PF00245 Alkaline phosphatase 0.0060 PF00167 Fibroblast growth factor 0.0057 PF02793 Hormone receptor domain 0.0057 PF00002 7 transmembrane receptor (Secretin family), 0.0057 PF01039 Carboxyl transferase domain 0.0056 PF08725 Integrin beta cytoplasmic domain 0.0056 PF00958 GMP synthase C terminal domain 0.0055 PF00364 Biotin-requiring enzyme 0.0055 PF01323 DSBA-like thioredoxin domain 0.0054 PF02060 Slow voltage-gated potassium channel 0.0048 PF05649 Peptidase family M13 0.0048 PF01431 Peptidase family M13 0.0046 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0044 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0044 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0043 PF02574 Homocysteine S-methyltransferase 0.0043 PF00206 Lyase 0.0041 PF00273 Serum albumin family 0.0039 PF02038 ATP1G1/PLM/MAT8 family 0.0037 PF00357 Integrin alpha cytoplasmic region 0.0033 PF03099 Biotin/lipoate A/B protein ligase family 0.0032 PF07965 Integrin beta tail domain 0.0032 PF00362 Integrin, beta chain 0.0030 PF01641 SelR domain 0.0030 PF08326 Acetyl-CoA carboxylase, central region 0.0030 PF09334 tRNA synthetases class I (M), 0.0030 PF01406 tRNA synthetases class I (C), catalytic domain 0.0029 PF06617 M-phase inducer phosphatase 0.0029 PF00581 Rhodanese-like domain 0.0023 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0023 PF01234 NNMT/PNMT/TEMT family 0.0023 PF02146 Sir2 family 0.0020 PF00112 Papain family cysteine protease 0.0019 PF10420 Cytokine interleukin-12p40 C-terminus 0.0018 PF00230 Major intrinsic protein 0.0015 PF00474 Sodium:solute symporter family 0.0015 PF01916 Deoxyhypusine synthase 0.0012 PF05995 Cysteine dioxygenase type I 0.0012 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0012 PF03199 Eukaryotic glutathione synthase 0.0009 PF08919 F-actin binding 0.0006 PF04055 Radical SAM superfamily 0.0006 PF08833 Axin beta-catenin binding domain 0.0006 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0006 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0006 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0006 PF00778 DIX domain 0.0005 PF01731 Arylesterase 0.0005 PF00020 TNFR/NGFR cysteine-rich region 0.0003 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0002 PF00806 Pumilio-family RNA binding repeat 0.0002 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0002 PF01019 Gamma-glutamyltranspeptidase 0.0002 PF01835 MG2 domain 0.0002 PF02189 Immunoreceptor tyrosine-based activation motif 0.0002 PF01244 Membrane dipeptidase (Peptidase family M19), 0.0002 PF01733 Nucleoside transporter 0.0002 PF02493 MORN repeat 0.0002 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0002 PF00756 Putative esterase 0.0002 PF00439 Bromodomain 0.0002 PF00462 Glutaredoxin 0.0002 PF02237 Biotin protein ligase C terminal domain 0.0002 PF01625 Peptide methionine sulfoxide reductase 0.0002 PF07678 A-macroglobulin complement component 0.0002 PF07677 A-macroglobulin receptor 0.0002 PF00856 SET domain 0.0002 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0002 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF03372 Endonuclease/Exonuclease/phosphatase family SUB809 SC1CC(S)CCC1 0.4281 PF00194 Eukaryotic-type carbonic anhydrase 0.1817 PF08403 Amino acid permease N-terminal 0.1774 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1774 PF02254 TrkA-N domain 0.0833 PF00324 Amino acid permease 0.0459 PF00690 Cation transporter/ATPase, N-terminus 0.0459 PF00689 Cation transporting ATPase, C-terminus 0.0426 PF00520 Ion transport protein 0.0408 PF00122 E1-E2 ATPase 0.0365 PF00702 haloacid dehalogenase-like hydrolase 0.0325 PF02038 ATP1G1/PLM/MAT8 family 0.0181 PF02146 Sir2 family 0.0172 PF09396 Thrombin light chain 0.0130 PF02060 Slow voltage-gated potassium channel 0.0085 PF03520 KCNQ voltage-gated potassium channel 0.0084 PF00167 Fibroblast growth factor 0.0065 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0061 PF01007 Inward rectifier potassium channel 0.0042 PF00051 Kringle domain 0.0023 PF00045 Hemopexin 0.0023 PF01471 Putative peptidoglycan binding domain 0.0022 PF01916 Deoxyhypusine synthase 0.0020 PF00413 Matrixin 0.0016 PF02803 Thiolase, C-terminal domain 0.0016 PF00108 Thiolase, N-terminal domain 0.0013 PF02185 Hr1 repeat 0.0013 PF01590 GAF domain 0.0013 PF08912 Rho Binding 0.0007 PF10420 Cytokine interleukin-12p40 C-terminus 0.0003 PF08447 PAS fold 0.0003 PF08466 Inward rectifier potassium channel N-terminal 0.0003 PF00230 Major intrinsic protein 0.0002 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0002 PF03662 Glycosyl hydrolase family 79, N-terminal domain SUB746 Sc1cc(S)ccc1 0.4281 PF00194 Eukaryotic-type carbonic anhydrase 0.1817 PF08403 Amino acid permease N-terminal 0.1774 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1774 PF02254 TrkA-N domain 0.0833 PF00324 Amino acid permease 0.0459 PF00690 Cation transporter/ATPase, N-terminus 0.0459 PF00689 Cation transporting ATPase, C-terminus 0.0426 PF00520 Ion transport protein 0.0408 PF00122 E1-E2 ATPase 0.0365 PF00702 haloacid dehalogenase-like hydrolase 0.0325 PF02038 ATP1G1/PLM/MAT8 family 0.0181 PF02146 Sir2 family 0.0172 PF09396 Thrombin light chain 0.0130 PF02060 Slow voltage-gated potassium channel 0.0085 PF03520 KCNQ voltage-gated potassium channel 0.0084 PF00167 Fibroblast growth factor 0.0065 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0061 PF01007 Inward rectifier potassium channel 0.0042 PF00051 Kringle domain 0.0023 PF00045 Hemopexin 0.0023 PF01471 Putative peptidoglycan binding domain 0.0022 PF01916 Deoxyhypusine synthase 0.0020 PF00413 Matrixin 0.0016 PF00108 Thiolase, N-terminal domain 0.0016 PF02803 Thiolase, C-terminal domain 0.0013 PF02185 Hr1 repeat 0.0013 PF08912 Rho Binding 0.0013 PF01590 GAF domain 0.0007 PF10420 Cytokine interleukin-12p40 C-terminus 0.0003 PF00230 Major intrinsic protein 0.0003 PF08466 Inward rectifier potassium channel N-terminal 0.0003 PF08447 PAS fold 0.0002 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0002 PF03662 Glycosyl hydrolase family 79, N-terminal domain SUB372 C(~H)(:C)(:C) 0.4193 PF00001 7 transmembrane receptor (rhodopsin family), 0.1922 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.1402 PF00209 Sodium:neurotransmitter symporter family 0.1274 PF03098 Animal haem peroxidase 0.1163 PF00194 Eukaryotic-type carbonic anhydrase 0.1017 PF00204 DNA gyrase B 0.1017 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1017 PF08070 DTHCT (NUC029), region 0.0943 PF06512 Sodium ion transport-associated 0.0845 PF00520 Ion transport protein 0.0797 PF03073 TspO/MBR family 0.0494 PF00989 PAS fold 0.0413 PF00027 Cyclic nucleotide-binding domain 0.0408 PF09396 Thrombin light chain 0.0363 PF00102 Protein-tyrosine phosphatase 0.0354 PF00186 Dihydrofolate reductase 0.0319 PF01593 Flavin containing amine oxidoreductase 0.0306 PF00576 HIUase/Transthyretin family 0.0280 PF08403 Amino acid permease N-terminal 0.0254 PF01007 Inward rectifier potassium channel 0.0215 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0192 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0174 PF00005 ABC transporter 0.0134 PF02254 TrkA-N domain 0.0134 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0116 PF07884 Vitamin K epoxide reductase family 0.0115 PF05649 Peptidase family M13 0.0115 PF01431 Peptidase family M13 0.0109 PF01401 Angiotensin-converting enzyme 0.0100 PF00017 SH2 domain 0.0098 PF00664 ABC transporter transmembrane region 0.0073 PF02159 Oestrogen receptor 0.0069 PF00069 Protein kinase domain 0.0061 PF00822 PMP-22/EMP/MP20/Claudin family 0.0061 PF12497 Estrogen receptor beta 0.0053 PF00018 SH3 domain 0.0048 PF08983 Domain of unknown function (DUF1856), 0.0048 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0039 PF00042 Globin 0.0014 PF00067 Cytochrome P450 0.0003 PF00089 Trypsin SUB459 S(-O)(=O) 0.4163 PF00194 Eukaryotic-type carbonic anhydrase 0.1095 PF08403 Amino acid permease N-terminal 0.0726 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0726 PF02254 TrkA-N domain 0.0559 PF01007 Inward rectifier potassium channel 0.0552 PF00324 Amino acid permease 0.0452 PF00045 Hemopexin 0.0452 PF01471 Putative peptidoglycan binding domain 0.0422 PF00413 Matrixin 0.0364 PF00690 Cation transporter/ATPase, N-terminus 0.0364 PF00689 Cation transporting ATPase, C-terminus 0.0324 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0323 PF00122 E1-E2 ATPase 0.0314 PF09396 Thrombin light chain 0.0278 PF00702 haloacid dehalogenase-like hydrolase 0.0269 PF00664 ABC transporter transmembrane region 0.0266 PF00005 ABC transporter 0.0257 PF03098 Animal haem peroxidase 0.0238 PF01590 GAF domain 0.0212 PF00167 Fibroblast growth factor 0.0208 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0192 PF00089 Trypsin 0.0185 PF00027 Cyclic nucleotide-binding domain 0.0181 PF00520 Ion transport protein 0.0170 PF00989 PAS fold 0.0161 PF00102 Protein-tyrosine phosphatase 0.0140 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0137 PF00051 Kringle domain 0.0127 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0112 PF00112 Papain family cysteine protease 0.0106 PF02146 Sir2 family 0.0106 PF02185 Hr1 repeat 0.0106 PF08912 Rho Binding 0.0105 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0103 PF08725 Integrin beta cytoplasmic domain 0.0103 PF02038 ATP1G1/PLM/MAT8 family 0.0102 PF02060 Slow voltage-gated potassium channel 0.0101 PF08441 Integrin alpha 0.0092 PF00188 Cysteine-rich secretory protein family 0.0092 PF02820 mbt repeat 0.0092 PF01530 Zinc finger, C2HC type 0.0089 PF07885 Ion channel 0.0086 PF07965 Integrin beta tail domain 0.0086 PF00362 Integrin, beta chain 0.0085 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0081 PF00489 Interleukin-6/G-CSF/MGF family 0.0080 PF01916 Deoxyhypusine synthase 0.0075 PF00230 Major intrinsic protein 0.0075 PF08466 Inward rectifier potassium channel N-terminal 0.0072 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0072 PF00578 AhpC/TSA family 0.0070 PF08447 PAS fold 0.0069 PF00108 Thiolase, N-terminal domain 0.0069 PF02803 Thiolase, C-terminal domain 0.0068 PF07966 A1 Propeptide 0.0068 PF00581 Rhodanese-like domain 0.0068 PF06617 M-phase inducer phosphatase 0.0063 PF00040 Fibronectin type II domain 0.0060 PF08702 Fibrinogen alpha/beta chain family 0.0060 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0060 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0059 PF03489 Saposin-like type B, region 2 0.0059 PF01323 DSBA-like thioredoxin domain 0.0058 PF03520 KCNQ voltage-gated potassium channel 0.0052 PF00357 Integrin alpha cytoplasmic region 0.0049 PF00287 Sodium / potassium ATPase beta chain 0.0047 PF00757 Furin-like cysteine rich region 0.0047 PF01030 Receptor L domain 0.0043 PF00092 von Willebrand factor type A domain 0.0043 PF01234 NNMT/PNMT/TEMT family 0.0042 PF00026 Eukaryotic aspartyl protease 0.0041 PF00822 PMP-22/EMP/MP20/Claudin family 0.0036 PF00625 Guanylate kinase 0.0034 PF12497 Estrogen receptor beta 0.0034 PF00341 Platelet-derived growth factor (PDGF), 0.0032 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0031 PF08399 VWA N-terminal 0.0031 PF02743 Cache domain 0.0031 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0027 PF09193 Cholecystokinin A receptor, N-terminal 0.0024 PF00337 Galactoside-binding lectin 0.0020 PF12160 Fibrinogen alpha C domain 0.0020 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0019 PF00084 Sushi domain (SCR repeat), 0.0017 PF00656 Caspase domain 0.0017 PF00183 Hsp90 protein 0.0017 PF00431 CUB domain 0.0017 PF07645 Calcium-binding EGF domain 0.0017 PF00850 Histone deacetylase domain 0.0017 PF00024 PAN domain 0.0016 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0013 PF00058 Low-density lipoprotein receptor repeat class B 0.0013 PF00059 Lectin C-type domain 0.0011 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF00433 Protein kinase C terminal domain 0.0003 PF11857 Domain of unknown function (DUF3377), 0.0002 PF07992 Pyridine nucleotide-disulphide oxidoreductase SUB60 >= 1 Co 0.4096 PF01122 Eukaryotic cobalamin-binding protein 0.3030 PF02310 B12 binding domain 0.2874 PF01642 Methylmalonyl-CoA mutase 0.2874 PF01923 Cobalamin adenosyltransferase 0.2874 PF03308 ArgK protein 0.1367 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.1367 PF02607 B12 binding domain 0.1367 PF00809 Pterin binding enzyme 0.1336 PF00431 CUB domain 0.1259 PF00667 FAD binding domain 0.1259 PF00258 Flavodoxin 0.1236 PF00175 Oxidoreductase NAD-binding domain 0.0877 PF07645 Calcium-binding EGF domain 0.0702 PF02574 Homocysteine S-methyltransferase 0.0386 PF02223 Thymidylate kinase 0.0355 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0321 PF08240 Alcohol dehydrogenase GroES-like domain 0.0309 PF00106 short chain dehydrogenase 0.0281 PF00107 Zinc-binding dehydrogenase 0.0278 PF00478 IMP dehydrogenase / GMP reductase domain 0.0256 PF01126 Heme oxygenase 0.0248 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0233 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0233 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0233 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0231 PF00171 Aldehyde dehydrogenase family 0.0231 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0231 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0218 PF02267 ADP-ribosyl cyclase 0.0217 PF00571 CBS domain 0.0217 PF00248 Aldo/keto reductase family 0.0200 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0200 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0171 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0162 PF01467 Cytidylyltransferase 0.0159 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0156 PF00970 Oxidoreductase FAD-binding domain 0.0142 PF01652 Eukaryotic initiation factor 4E 0.0132 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0132 PF02233 NAD(P), transhydrogenase beta subunit 0.0132 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0132 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0130 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0130 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0117 PF03770 Inositol polyphosphate kinase 0.0117 PF02036 SCP-2 sterol transfer family 0.0117 PF01575 MaoC like domain 0.0116 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0115 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0115 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0111 PF00390 Malic enzyme, N-terminal domain 0.0111 PF03949 Malic enzyme, NAD binding domain 0.0107 PF01687 Riboflavin kinase 0.0106 PF01370 NAD dependent epimerase/dehydratase family 0.0106 PF00057 Low-density lipoprotein receptor domain class A 0.0105 PF01268 Formate--tetrahydrofolate ligase 0.0105 PF00058 Low-density lipoprotein receptor repeat class B 0.0096 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0096 PF00676 Dehydrogenase E1 component 0.0096 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0096 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0094 PF00069 Protein kinase domain 0.0094 PF02525 Flavodoxin-like fold 0.0090 PF00017 SH2 domain 0.0089 PF00348 Polyprenyl synthetase 0.0087 PF00186 Dihydrofolate reductase 0.0073 PF00018 SH3 domain 0.0071 PF01230 HIT domain 0.0067 PF00378 Enoyl-CoA hydratase/isomerase family 0.0065 PF05347 Complex 1 protein (LYR family), 0.0065 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0059 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0056 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0056 PF02779 Transketolase, pyrimidine binding domain 0.0056 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0055 PF01833 IPT/TIG domain 0.0055 PF01437 Plexin repeat 0.0055 PF01403 Sema domain 0.0047 PF00501 AMP-binding enzyme 0.0045 PF01119 DNA mismatch repair protein, C-terminal domain 0.0045 PF12473 Kinesin protein 0.0045 PF08676 MutL C terminal dimerisation domain 0.0045 PF00498 FHA domain 0.0045 PF12423 Kinesin protein 1B 0.0037 PF00794 PI3-kinase family, ras-binding domain 0.0037 PF00792 Phosphoinositide 3-kinase C2 0.0037 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0036 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0036 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0032 PF00931 NB-ARC domain 0.0032 PF00400 WD domain, G-beta repeat 0.0029 PF01808 AICARFT/IMPCHase bienzyme 0.0028 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0028 PF00225 Kinesin motor domain 0.0025 PF01712 Deoxynucleoside kinase 0.0024 PF04116 Fatty acid hydroxylase superfamily 0.0024 PF08040 MNLL subunit 0.0024 PF02466 Tim17/Tim22/Tim23 family 0.0024 PF10531 SLBB domain 0.0024 PF02817 e3 binding domain 0.0024 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0024 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0024 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0024 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0024 PF09166 Biliverdin reductase, catalytic 0.0024 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0024 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0024 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0024 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0024 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0024 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0024 PF00384 Molybdopterin oxidoreductase 0.0024 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0024 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0024 PF04716 ETC complex I subunit conserved region 0.0024 PF10276 Zinc-finger domain 0.0024 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0024 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0024 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0024 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0024 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0024 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0024 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0024 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0024 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0024 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0024 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0024 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0024 PF06212 GRIM-19 protein 0.0024 PF04800 ETC complex I subunit conserved region 0.0024 PF09326 Domain of unknown function (DUF1982), 0.0024 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0024 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0024 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0024 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0024 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0018 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0018 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0015 PF02173 pKID domain 0.0015 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0013 PF00962 Adenosine/AMP deaminase 0.0011 PF02780 Transketolase, C-terminal domain 0.0011 PF03435 Saccharopine dehydrogenase 0.0010 PF00042 Globin 0.0010 PF00406 Adenylate kinase 0.0009 PF08515 Transforming growth factor beta type I GS-motif 0.0009 PF01064 Activin types I and II receptor domain 0.0008 PF00170 bZIP transcription factor 0.0002 PF00169 PH domain 0.0002 PF00779 BTK motif 0.0001 PF03727 Hexokinase 0.0001 PF00349 Hexokinase 0.0001 PF04679 ATP dependent DNA ligase C terminal region 0.0001 PF01068 ATP dependent DNA ligase domain SUB294 C-S 0.4000 PF00194 Eukaryotic-type carbonic anhydrase 0.0932 PF08403 Amino acid permease N-terminal 0.0572 PF03953 Tubulin C-terminal domain 0.0572 PF00091 Tubulin/FtsZ family, GTPase domain 0.0550 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0550 PF02254 TrkA-N domain 0.0499 PF01471 Putative peptidoglycan binding domain 0.0499 PF00045 Hemopexin 0.0458 PF00413 Matrixin 0.0450 PF01007 Inward rectifier potassium channel 0.0429 PF00324 Amino acid permease 0.0418 PF00001 7 transmembrane receptor (rhodopsin family), 0.0392 PF02798 Glutathione S-transferase, N-terminal domain 0.0389 PF00043 Glutathione S-transferase, C-terminal domain 0.0364 PF00102 Protein-tyrosine phosphatase 0.0260 PF00689 Cation transporting ATPase, C-terminus 0.0260 PF00690 Cation transporter/ATPase, N-terminus 0.0241 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0219 PF00122 E1-E2 ATPase 0.0204 PF01590 GAF domain 0.0181 PF00664 ABC transporter transmembrane region 0.0166 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0161 PF00702 haloacid dehalogenase-like hydrolase 0.0159 PF08983 Domain of unknown function (DUF1856), 0.0151 PF00005 ABC transporter 0.0149 PF00156 Phosphoribosyl transferase domain 0.0136 PF00255 Glutathione peroxidase 0.0135 PF00854 POT family 0.0135 PF00478 IMP dehydrogenase / GMP reductase domain 0.0128 PF09396 Thrombin light chain 0.0125 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0123 PF01770 Reduced folate carrier 0.0122 PF00962 Adenosine/AMP deaminase 0.0111 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0111 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0104 PF02772 S-adenosylmethionine synthetase, central domain 0.0104 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0104 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0101 PF03098 Animal haem peroxidase 0.0096 PF10397 Adenylosuccinate lyase C-terminus 0.0091 PF01068 ATP dependent DNA ligase domain 0.0091 PF04679 ATP dependent DNA ligase C terminal region 0.0090 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0072 PF12497 Estrogen receptor beta 0.0068 PF02785 Biotin carboxylase C-terminal domain 0.0068 PF00108 Thiolase, N-terminal domain 0.0068 PF11857 Domain of unknown function (DUF3377), 0.0068 PF02803 Thiolase, C-terminal domain 0.0063 PF01124 MAPEG family 0.0061 PF00656 Caspase domain 0.0060 PF08912 Rho Binding 0.0060 PF02185 Hr1 repeat 0.0059 PF08441 Integrin alpha 0.0058 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0056 PF04321 RmlD substrate binding domain 0.0056 PF00245 Alkaline phosphatase 0.0055 PF00167 Fibroblast growth factor 0.0052 PF08725 Integrin beta cytoplasmic domain 0.0052 PF01039 Carboxyl transferase domain 0.0052 PF00002 7 transmembrane receptor (Secretin family), 0.0052 PF02793 Hormone receptor domain 0.0051 PF00958 GMP synthase C terminal domain 0.0051 PF01323 DSBA-like thioredoxin domain 0.0050 PF00364 Biotin-requiring enzyme 0.0049 PF02060 Slow voltage-gated potassium channel 0.0044 PF05649 Peptidase family M13 0.0044 PF01431 Peptidase family M13 0.0042 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0041 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0041 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0040 PF00206 Lyase 0.0039 PF02574 Homocysteine S-methyltransferase 0.0037 PF00273 Serum albumin family 0.0036 PF02038 ATP1G1/PLM/MAT8 family 0.0033 PF00357 Integrin alpha cytoplasmic region 0.0030 PF03099 Biotin/lipoate A/B protein ligase family 0.0029 PF07965 Integrin beta tail domain 0.0029 PF00362 Integrin, beta chain 0.0027 PF01406 tRNA synthetases class I (C), catalytic domain 0.0027 PF06617 M-phase inducer phosphatase 0.0027 PF09334 tRNA synthetases class I (M), 0.0027 PF01641 SelR domain 0.0027 PF08326 Acetyl-CoA carboxylase, central region 0.0027 PF00581 Rhodanese-like domain 0.0021 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0021 PF01234 NNMT/PNMT/TEMT family 0.0021 PF02146 Sir2 family 0.0019 PF00112 Papain family cysteine protease 0.0018 PF10420 Cytokine interleukin-12p40 C-terminus 0.0017 PF00230 Major intrinsic protein 0.0014 PF00474 Sodium:solute symporter family 0.0013 PF01916 Deoxyhypusine synthase 0.0011 PF03199 Eukaryotic glutathione synthase 0.0011 PF05995 Cysteine dioxygenase type I 0.0011 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0009 PF08919 F-actin binding 0.0006 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0006 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0006 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0006 PF08833 Axin beta-catenin binding domain 0.0006 PF00778 DIX domain 0.0006 PF04055 Radical SAM superfamily 0.0004 PF00020 TNFR/NGFR cysteine-rich region 0.0004 PF01731 Arylesterase 0.0003 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0002 PF01019 Gamma-glutamyltranspeptidase 0.0002 PF01835 MG2 domain 0.0002 PF02493 MORN repeat 0.0002 PF00439 Bromodomain 0.0002 PF02237 Biotin protein ligase C terminal domain 0.0002 PF01625 Peptide methionine sulfoxide reductase 0.0002 PF07678 A-macroglobulin complement component 0.0002 PF07677 A-macroglobulin receptor 0.0002 PF00806 Pumilio-family RNA binding repeat 0.0002 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0002 PF01244 Membrane dipeptidase (Peptidase family M19), 0.0002 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0002 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0002 PF02189 Immunoreceptor tyrosine-based activation motif 0.0002 PF00856 SET domain 0.0002 PF00462 Glutaredoxin 0.0002 PF00756 Putative esterase 0.0002 PF01733 Nucleoside transporter 0.0002 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF03372 Endonuclease/Exonuclease/phosphatase family SUB354 C(~C)(~S) 0.3927 PF00194 Eukaryotic-type carbonic anhydrase 0.0915 PF08403 Amino acid permease N-terminal 0.0562 PF03953 Tubulin C-terminal domain 0.0562 PF00091 Tubulin/FtsZ family, GTPase domain 0.0540 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0540 PF02254 TrkA-N domain 0.0490 PF01471 Putative peptidoglycan binding domain 0.0490 PF00045 Hemopexin 0.0449 PF00413 Matrixin 0.0441 PF01007 Inward rectifier potassium channel 0.0421 PF00324 Amino acid permease 0.0411 PF00001 7 transmembrane receptor (rhodopsin family), 0.0384 PF02798 Glutathione S-transferase, N-terminal domain 0.0382 PF00043 Glutathione S-transferase, C-terminal domain 0.0358 PF00102 Protein-tyrosine phosphatase 0.0255 PF00690 Cation transporter/ATPase, N-terminus 0.0255 PF00689 Cation transporting ATPase, C-terminus 0.0237 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0215 PF00122 E1-E2 ATPase 0.0200 PF01590 GAF domain 0.0178 PF00664 ABC transporter transmembrane region 0.0163 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0159 PF00702 haloacid dehalogenase-like hydrolase 0.0156 PF08983 Domain of unknown function (DUF1856), 0.0148 PF00005 ABC transporter 0.0146 PF00156 Phosphoribosyl transferase domain 0.0133 PF00854 POT family 0.0133 PF00255 Glutathione peroxidase 0.0133 PF00478 IMP dehydrogenase / GMP reductase domain 0.0126 PF09396 Thrombin light chain 0.0123 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0121 PF01770 Reduced folate carrier 0.0120 PF00962 Adenosine/AMP deaminase 0.0109 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0109 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0102 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0102 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0102 PF02772 S-adenosylmethionine synthetase, central domain 0.0099 PF03098 Animal haem peroxidase 0.0095 PF10397 Adenylosuccinate lyase C-terminus 0.0089 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0089 PF04679 ATP dependent DNA ligase C terminal region 0.0089 PF01068 ATP dependent DNA ligase domain 0.0070 PF12497 Estrogen receptor beta 0.0067 PF11857 Domain of unknown function (DUF3377), 0.0066 PF00108 Thiolase, N-terminal domain 0.0066 PF02803 Thiolase, C-terminal domain 0.0066 PF02785 Biotin carboxylase C-terminal domain 0.0062 PF01124 MAPEG family 0.0060 PF00656 Caspase domain 0.0058 PF02185 Hr1 repeat 0.0058 PF08441 Integrin alpha 0.0058 PF08912 Rho Binding 0.0057 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0055 PF04321 RmlD substrate binding domain 0.0055 PF00245 Alkaline phosphatase 0.0054 PF00167 Fibroblast growth factor 0.0051 PF02793 Hormone receptor domain 0.0051 PF01039 Carboxyl transferase domain 0.0051 PF00002 7 transmembrane receptor (Secretin family), 0.0051 PF08725 Integrin beta cytoplasmic domain 0.0050 PF01323 DSBA-like thioredoxin domain 0.0050 PF00958 GMP synthase C terminal domain 0.0049 PF00364 Biotin-requiring enzyme 0.0048 PF02060 Slow voltage-gated potassium channel 0.0043 PF01431 Peptidase family M13 0.0043 PF05649 Peptidase family M13 0.0042 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0040 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0040 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0039 PF00206 Lyase 0.0038 PF02574 Homocysteine S-methyltransferase 0.0036 PF00273 Serum albumin family 0.0035 PF02038 ATP1G1/PLM/MAT8 family 0.0033 PF00357 Integrin alpha cytoplasmic region 0.0030 PF03099 Biotin/lipoate A/B protein ligase family 0.0028 PF00362 Integrin, beta chain 0.0028 PF07965 Integrin beta tail domain 0.0027 PF01641 SelR domain 0.0027 PF01406 tRNA synthetases class I (C), catalytic domain 0.0027 PF09334 tRNA synthetases class I (M), 0.0027 PF08326 Acetyl-CoA carboxylase, central region 0.0026 PF06617 M-phase inducer phosphatase 0.0026 PF00581 Rhodanese-like domain 0.0021 PF02146 Sir2 family 0.0021 PF01234 NNMT/PNMT/TEMT family 0.0021 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0018 PF00112 Papain family cysteine protease 0.0017 PF10420 Cytokine interleukin-12p40 C-terminus 0.0017 PF00230 Major intrinsic protein 0.0014 PF00474 Sodium:solute symporter family 0.0013 PF01916 Deoxyhypusine synthase 0.0011 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0011 PF05995 Cysteine dioxygenase type I 0.0011 PF03199 Eukaryotic glutathione synthase 0.0008 PF08919 F-actin binding 0.0006 PF04055 Radical SAM superfamily 0.0006 PF00778 DIX domain 0.0006 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0006 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0006 PF08833 Axin beta-catenin binding domain 0.0006 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0004 PF01731 Arylesterase 0.0004 PF00020 TNFR/NGFR cysteine-rich region 0.0003 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0002 PF01625 Peptide methionine sulfoxide reductase 0.0002 PF02237 Biotin protein ligase C terminal domain 0.0002 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0002 PF01835 MG2 domain 0.0002 PF01733 Nucleoside transporter 0.0002 PF01019 Gamma-glutamyltranspeptidase 0.0002 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0002 PF00439 Bromodomain 0.0002 PF00462 Glutaredoxin 0.0002 PF07677 A-macroglobulin receptor 0.0002 PF07678 A-macroglobulin complement component 0.0002 PF00856 SET domain 0.0002 PF00756 Putative esterase 0.0002 PF02189 Immunoreceptor tyrosine-based activation motif 0.0002 PF00806 Pumilio-family RNA binding repeat 0.0002 PF01244 Membrane dipeptidase (Peptidase family M19), 0.0002 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0002 PF02493 MORN repeat 0.0002 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0001 PF03372 Endonuclease/Exonuclease/phosphatase family SUB768 Sc1c(N)cccc1 0.3909 PF00194 Eukaryotic-type carbonic anhydrase 0.1900 PF02254 TrkA-N domain 0.1900 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1604 PF08403 Amino acid permease N-terminal 0.1504 PF00001 7 transmembrane receptor (rhodopsin family), 0.0676 PF00324 Amino acid permease 0.0498 PF00690 Cation transporter/ATPase, N-terminus 0.0498 PF00689 Cation transporting ATPase, C-terminus 0.0438 PF00122 E1-E2 ATPase 0.0391 PF00520 Ion transport protein 0.0385 PF00702 haloacid dehalogenase-like hydrolase 0.0341 PF02038 ATP1G1/PLM/MAT8 family 0.0177 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0117 PF00043 Glutathione S-transferase, C-terminal domain 0.0110 PF02798 Glutathione S-transferase, N-terminal domain 0.0100 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0085 PF00822 PMP-22/EMP/MP20/Claudin family 0.0068 PF00357 Integrin alpha cytoplasmic region 0.0045 PF08441 Integrin alpha 0.0040 PF01734 Patatin-like phospholipase 0.0036 PF00757 Furin-like cysteine rich region 0.0036 PF01030 Receptor L domain 0.0031 PF09396 Thrombin light chain 0.0024 PF00102 Protein-tyrosine phosphatase 0.0015 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0015 PF01582 TIR domain 0.0015 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0015 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0015 PF01007 Inward rectifier potassium channel 0.0013 PF00042 Globin 0.0005 PF00305 Lipoxygenase SUB180 >= 1 saturated or aromatic carbon-only ring size 6 0.3897 PF00001 7 transmembrane receptor (rhodopsin family), 0.1790 PF02159 Oestrogen receptor 0.1663 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.1653 PF00105 Zinc finger, C4 type (two domains), 0.1643 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1579 PF03098 Animal haem peroxidase 0.1107 PF00209 Sodium:neurotransmitter symporter family 0.0763 PF06512 Sodium ion transport-associated 0.0756 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0756 PF08070 DTHCT (NUC029), region 0.0756 PF00204 DNA gyrase B 0.0600 PF00520 Ion transport protein 0.0463 PF03073 TspO/MBR family 0.0461 PF00191 Annexin 0.0440 PF02161 Progesterone receptor 0.0379 PF00194 Eukaryotic-type carbonic anhydrase 0.0358 PF00989 PAS fold 0.0343 PF09396 Thrombin light chain 0.0335 PF02155 Glucocorticoid receptor 0.0289 PF00027 Cyclic nucleotide-binding domain 0.0288 PF00067 Cytochrome P450 0.0213 PF01593 Flavin containing amine oxidoreductase 0.0150 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0130 PF00186 Dihydrofolate reductase 0.0124 PF01735 Lysophospholipase catalytic domain 0.0110 PF12497 Estrogen receptor beta 0.0108 PF01007 Inward rectifier potassium channel 0.0102 PF00305 Lipoxygenase 0.0082 PF00005 ABC transporter 0.0079 PF08403 Amino acid permease N-terminal 0.0061 PF00102 Protein-tyrosine phosphatase 0.0060 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0054 PF00576 HIUase/Transthyretin family 0.0037 PF00273 Serum albumin family 0.0033 PF00664 ABC transporter transmembrane region 0.0010 PF07884 Vitamin K epoxide reductase family 0.0010 PF00091 Tubulin/FtsZ family, GTPase domain 0.0010 PF03953 Tubulin C-terminal domain 0.0001 PF01431 Peptidase family M13 0.0001 PF05649 Peptidase family M13 SUB458 S(-C)(=O) 0.3829 PF00194 Eukaryotic-type carbonic anhydrase 0.1021 PF08403 Amino acid permease N-terminal 0.0688 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0688 PF02254 TrkA-N domain 0.0513 PF00324 Amino acid permease 0.0504 PF01007 Inward rectifier potassium channel 0.0407 PF01471 Putative peptidoglycan binding domain 0.0407 PF00045 Hemopexin 0.0380 PF00413 Matrixin 0.0337 PF00689 Cation transporting ATPase, C-terminus 0.0337 PF00690 Cation transporter/ATPase, N-terminus 0.0299 PF00122 E1-E2 ATPase 0.0293 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0286 PF09396 Thrombin light chain 0.0257 PF00702 haloacid dehalogenase-like hydrolase 0.0242 PF00664 ABC transporter transmembrane region 0.0240 PF00005 ABC transporter 0.0231 PF03098 Animal haem peroxidase 0.0214 PF01590 GAF domain 0.0193 PF00167 Fibroblast growth factor 0.0188 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0172 PF00089 Trypsin 0.0171 PF00520 Ion transport protein 0.0166 PF00027 Cyclic nucleotide-binding domain 0.0153 PF00989 PAS fold 0.0145 PF00102 Protein-tyrosine phosphatase 0.0126 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0124 PF00051 Kringle domain 0.0115 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0100 PF00112 Papain family cysteine protease 0.0099 PF02146 Sir2 family 0.0099 PF02038 ATP1G1/PLM/MAT8 family 0.0095 PF02060 Slow voltage-gated potassium channel 0.0095 PF08912 Rho Binding 0.0095 PF02185 Hr1 repeat 0.0094 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0093 PF08725 Integrin beta cytoplasmic domain 0.0091 PF08441 Integrin alpha 0.0083 PF02820 mbt repeat 0.0083 PF01530 Zinc finger, C2HC type 0.0083 PF00188 Cysteine-rich secretory protein family 0.0080 PF07885 Ion channel 0.0078 PF00362 Integrin, beta chain 0.0078 PF07965 Integrin beta tail domain 0.0076 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0073 PF01916 Deoxyhypusine synthase 0.0073 PF00489 Interleukin-6/G-CSF/MGF family 0.0068 PF00230 Major intrinsic protein 0.0068 PF08466 Inward rectifier potassium channel N-terminal 0.0065 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0065 PF00578 AhpC/TSA family 0.0063 PF08447 PAS fold 0.0062 PF02803 Thiolase, C-terminal domain 0.0062 PF00108 Thiolase, N-terminal domain 0.0061 PF00581 Rhodanese-like domain 0.0061 PF07966 A1 Propeptide 0.0061 PF06617 M-phase inducer phosphatase 0.0057 PF00040 Fibronectin type II domain 0.0054 PF08702 Fibrinogen alpha/beta chain family 0.0054 PF03489 Saposin-like type B, region 2 0.0054 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0054 PF03520 KCNQ voltage-gated potassium channel 0.0054 PF01323 DSBA-like thioredoxin domain 0.0054 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0047 PF00357 Integrin alpha cytoplasmic region 0.0044 PF00287 Sodium / potassium ATPase beta chain 0.0042 PF00757 Furin-like cysteine rich region 0.0042 PF01030 Receptor L domain 0.0039 PF00092 von Willebrand factor type A domain 0.0038 PF00026 Eukaryotic aspartyl protease 0.0038 PF01234 NNMT/PNMT/TEMT family 0.0037 PF00822 PMP-22/EMP/MP20/Claudin family 0.0033 PF00625 Guanylate kinase 0.0031 PF00341 Platelet-derived growth factor (PDGF), 0.0030 PF12497 Estrogen receptor beta 0.0029 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0028 PF08399 VWA N-terminal 0.0028 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0028 PF02743 Cache domain 0.0024 PF09193 Cholecystokinin A receptor, N-terminal 0.0022 PF00337 Galactoside-binding lectin 0.0018 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0018 PF12160 Fibrinogen alpha C domain 0.0017 PF00084 Sushi domain (SCR repeat), 0.0016 PF00850 Histone deacetylase domain 0.0016 PF00431 CUB domain 0.0015 PF00183 Hsp90 protein 0.0015 PF00656 Caspase domain 0.0015 PF00024 PAN domain 0.0015 PF07645 Calcium-binding EGF domain 0.0014 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0012 PF00058 Low-density lipoprotein receptor repeat class B 0.0012 PF00059 Lectin C-type domain 0.0010 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF00433 Protein kinase C terminal domain 0.0003 PF11857 Domain of unknown function (DUF3377), 0.0002 PF07992 Pyridine nucleotide-disulphide oxidoreductase SUB415 S(~C)(~O) 0.3829 PF00194 Eukaryotic-type carbonic anhydrase 0.1021 PF08403 Amino acid permease N-terminal 0.0688 PF02254 TrkA-N domain 0.0688 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0513 PF00324 Amino acid permease 0.0504 PF01007 Inward rectifier potassium channel 0.0407 PF00045 Hemopexin 0.0407 PF01471 Putative peptidoglycan binding domain 0.0380 PF00413 Matrixin 0.0337 PF00689 Cation transporting ATPase, C-terminus 0.0337 PF00690 Cation transporter/ATPase, N-terminus 0.0299 PF00122 E1-E2 ATPase 0.0293 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0286 PF09396 Thrombin light chain 0.0257 PF00702 haloacid dehalogenase-like hydrolase 0.0242 PF00664 ABC transporter transmembrane region 0.0240 PF00005 ABC transporter 0.0231 PF03098 Animal haem peroxidase 0.0214 PF01590 GAF domain 0.0193 PF00167 Fibroblast growth factor 0.0188 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0172 PF00089 Trypsin 0.0171 PF00520 Ion transport protein 0.0166 PF00027 Cyclic nucleotide-binding domain 0.0153 PF00989 PAS fold 0.0145 PF00102 Protein-tyrosine phosphatase 0.0126 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0124 PF00051 Kringle domain 0.0115 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0100 PF00112 Papain family cysteine protease 0.0099 PF02038 ATP1G1/PLM/MAT8 family 0.0099 PF02146 Sir2 family 0.0095 PF08912 Rho Binding 0.0095 PF02185 Hr1 repeat 0.0095 PF02060 Slow voltage-gated potassium channel 0.0094 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0093 PF08725 Integrin beta cytoplasmic domain 0.0091 PF08441 Integrin alpha 0.0083 PF00188 Cysteine-rich secretory protein family 0.0083 PF02820 mbt repeat 0.0083 PF01530 Zinc finger, C2HC type 0.0080 PF07885 Ion channel 0.0078 PF07965 Integrin beta tail domain 0.0078 PF00362 Integrin, beta chain 0.0076 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0073 PF00489 Interleukin-6/G-CSF/MGF family 0.0073 PF01916 Deoxyhypusine synthase 0.0068 PF00230 Major intrinsic protein 0.0068 PF08466 Inward rectifier potassium channel N-terminal 0.0065 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0065 PF00578 AhpC/TSA family 0.0063 PF08447 PAS fold 0.0062 PF02803 Thiolase, C-terminal domain 0.0062 PF00108 Thiolase, N-terminal domain 0.0061 PF00581 Rhodanese-like domain 0.0061 PF06617 M-phase inducer phosphatase 0.0061 PF07966 A1 Propeptide 0.0057 PF00040 Fibronectin type II domain 0.0054 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0054 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0054 PF03520 KCNQ voltage-gated potassium channel 0.0054 PF01323 DSBA-like thioredoxin domain 0.0054 PF03489 Saposin-like type B, region 2 0.0054 PF08702 Fibrinogen alpha/beta chain family 0.0047 PF00357 Integrin alpha cytoplasmic region 0.0044 PF00287 Sodium / potassium ATPase beta chain 0.0042 PF00757 Furin-like cysteine rich region 0.0042 PF01030 Receptor L domain 0.0039 PF00092 von Willebrand factor type A domain 0.0038 PF01234 NNMT/PNMT/TEMT family 0.0038 PF00026 Eukaryotic aspartyl protease 0.0037 PF00822 PMP-22/EMP/MP20/Claudin family 0.0033 PF00625 Guanylate kinase 0.0031 PF00341 Platelet-derived growth factor (PDGF), 0.0030 PF12497 Estrogen receptor beta 0.0029 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0028 PF08399 VWA N-terminal 0.0028 PF02743 Cache domain 0.0028 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0024 PF09193 Cholecystokinin A receptor, N-terminal 0.0022 PF00337 Galactoside-binding lectin 0.0018 PF12160 Fibrinogen alpha C domain 0.0018 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0017 PF00084 Sushi domain (SCR repeat), 0.0016 PF00850 Histone deacetylase domain 0.0016 PF00431 CUB domain 0.0015 PF07645 Calcium-binding EGF domain 0.0015 PF00656 Caspase domain 0.0015 PF00024 PAN domain 0.0015 PF00183 Hsp90 protein 0.0014 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0012 PF00058 Low-density lipoprotein receptor repeat class B 0.0012 PF00059 Lectin C-type domain 0.0010 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF00433 Protein kinase C terminal domain 0.0003 PF11857 Domain of unknown function (DUF3377), 0.0002 PF07992 Pyridine nucleotide-disulphide oxidoreductase SUB831 SC1C(N)CCCC1 0.3823 PF00194 Eukaryotic-type carbonic anhydrase 0.1858 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1858 PF02254 TrkA-N domain 0.1569 PF08403 Amino acid permease N-terminal 0.1471 PF00001 7 transmembrane receptor (rhodopsin family), 0.0661 PF00324 Amino acid permease 0.0487 PF00690 Cation transporter/ATPase, N-terminus 0.0487 PF00689 Cation transporting ATPase, C-terminus 0.0428 PF00122 E1-E2 ATPase 0.0382 PF00520 Ion transport protein 0.0377 PF00702 haloacid dehalogenase-like hydrolase 0.0334 PF02038 ATP1G1/PLM/MAT8 family 0.0173 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0114 PF00043 Glutathione S-transferase, C-terminal domain 0.0108 PF02798 Glutathione S-transferase, N-terminal domain 0.0098 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0083 PF00822 PMP-22/EMP/MP20/Claudin family 0.0067 PF00357 Integrin alpha cytoplasmic region 0.0044 PF08441 Integrin alpha 0.0039 PF01734 Patatin-like phospholipase 0.0036 PF01030 Receptor L domain 0.0036 PF00757 Furin-like cysteine rich region 0.0030 PF09396 Thrombin light chain 0.0024 PF00102 Protein-tyrosine phosphatase 0.0015 PF01007 Inward rectifier potassium channel 0.0014 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0014 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0014 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0014 PF01582 TIR domain 0.0013 PF00042 Globin 0.0004 PF00305 Lipoxygenase SUB706 O=C-C-C-C-C(O)-C 0.3816 PF00191 Annexin 0.3315 PF02155 Glucocorticoid receptor 0.1825 PF01735 Lysophospholipase catalytic domain 0.1771 PF00079 Serpin (serine protease inhibitor), 0.1116 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1090 PF00105 Zinc finger, C4 type (two domains), 0.1036 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1036 PF00204 DNA gyrase B 0.1036 PF08070 DTHCT (NUC029), region 0.0746 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0687 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0676 PF00168 C2 domain 0.0564 PF03953 Tubulin C-terminal domain 0.0564 PF00091 Tubulin/FtsZ family, GTPase domain 0.0552 PF00102 Protein-tyrosine phosphatase 0.0424 PF00557 Metallopeptidase family M24 0.0389 PF02180 Bcl-2 homology region 4 0.0389 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0335 PF00554 Rel homology domain (RHD), 0.0298 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0290 PF00183 Hsp90 protein 0.0289 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0285 PF00229 TNF(Tumour Necrosis Factor), family 0.0237 PF12497 Estrogen receptor beta 0.0235 PF00976 Corticotropin ACTH domain 0.0235 PF08035 Opioids neuropeptide 0.0235 PF08384 Pro-opiomelanocortin, N-terminal region 0.0225 PF03062 MBOAT family 0.0219 PF02173 pKID domain 0.0195 PF01477 PLAT/LH2 domain 0.0185 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0184 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0178 PF07690 Major Facilitator Superfamily 0.0161 PF02159 Oestrogen receptor 0.0153 PF00170 bZIP transcription factor 0.0148 PF00005 ABC transporter 0.0137 PF00656 Caspase domain 0.0136 PF00664 ABC transporter transmembrane region 0.0133 PF00151 Lipase 0.0132 PF01347 Lipoprotein amino terminal region 0.0128 PF02259 FAT domain 0.0128 PF02260 FATC domain 0.0128 PF08771 Rapamycin binding domain 0.0122 PF03171 2OG-Fe(II), oxygenase superfamily 0.0119 PF00341 Platelet-derived growth factor (PDGF), 0.0113 PF00531 Death domain 0.0108 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0102 PF07648 Kazal-type serine protease inhibitor domain 0.0096 PF02525 Flavodoxin-like fold 0.0093 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0093 PF00094 von Willebrand factor type D domain 0.0093 PF08742 C8 domain 0.0093 PF02025 Interleukin 5 0.0092 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0089 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0089 PF00305 Lipoxygenase 0.0087 PF00176 SNF2 family N-terminal domain 0.0083 PF00271 Helicase conserved C-terminal domain 0.0080 PF00698 Acyl transferase domain 0.0080 PF08659 KR domain 0.0080 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0080 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0080 PF00975 Thioesterase domain 0.0075 PF00432 Prenyltransferase and squalene oxidase repeat 0.0071 PF00493 MCM2/3/5 family 0.0063 PF01596 O-methyltransferase 0.0055 PF02758 PAAD/DAPIN/Pyrin domain 0.0051 PF01391 Collagen triple helix repeat (20 copies), 0.0049 PF00023 Ankyrin repeat 0.0045 PF02887 Pyruvate kinase, alpha/beta domain 0.0045 PF00224 Pyruvate kinase, barrel domain 0.0044 PF03360 Glycosyltransferase family 43 0.0043 PF00377 Prion/Doppel alpha-helical domain 0.0041 PF02166 Androgen receptor 0.0041 PF00167 Fibroblast growth factor 0.0041 PF00040 Fibronectin type II domain 0.0041 PF00489 Interleukin-6/G-CSF/MGF family 0.0035 PF00274 Fructose-bisphosphate aldolase class-I 0.0034 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0034 PF07884 Vitamin K epoxide reductase family 0.0032 PF02460 Patched family 0.0032 PF00340 Interleukin-1 / 18 0.0032 PF02394 Interleukin-1 propeptide 0.0032 PF00354 Pentaxin family 0.0030 PF01061 ABC-2 type transporter 0.0026 PF02161 Progesterone receptor 0.0025 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0025 PF00969 Class II histocompatibility antigen, beta domain 0.0024 PF00071 Ras family 0.0024 PF03623 Focal adhesion targeting region 0.0023 PF12491 Apolipoprotein B100 C terminal 0.0023 PF06448 Domain of Unknown Function (DUF1081), 0.0021 PF00622 SPRY domain 0.0020 PF00643 B-box zinc finger 0.0019 PF01023 S-100/ICaBP type calcium binding domain 0.0017 PF00067 Cytochrome P450 0.0015 PF00074 Pancreatic ribonuclease 0.0014 PF00342 Phosphoglucose isomerase 0.0006 PF00550 Phosphopantetheine attachment site 0.0001 PF02373 JmjC domain 0.0001 PF02375 jmjN domain 0.0001 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0001 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0001 PF00860 Permease family 0.0001 PF01753 MYND finger 0.0001 PF08429 PLU-1-like protein 0.0001 PF01388 ARID/BRIGHT DNA binding domain 0.0001 PF00628 PHD-finger 0.0001 PF02928 C5HC2 zinc finger SUB460 S(=O)(=O) 0.3755 PF00194 Eukaryotic-type carbonic anhydrase 0.1006 PF08403 Amino acid permease N-terminal 0.0683 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0683 PF02254 TrkA-N domain 0.0505 PF00324 Amino acid permease 0.0490 PF01007 Inward rectifier potassium channel 0.0396 PF00045 Hemopexin 0.0396 PF01471 Putative peptidoglycan binding domain 0.0369 PF00413 Matrixin 0.0331 PF00690 Cation transporter/ATPase, N-terminus 0.0331 PF00689 Cation transporting ATPase, C-terminus 0.0294 PF00122 E1-E2 ATPase 0.0285 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0279 PF09396 Thrombin light chain 0.0253 PF00702 haloacid dehalogenase-like hydrolase 0.0235 PF00664 ABC transporter transmembrane region 0.0233 PF00005 ABC transporter 0.0225 PF03098 Animal haem peroxidase 0.0208 PF01590 GAF domain 0.0188 PF00167 Fibroblast growth factor 0.0182 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0169 PF00520 Ion transport protein 0.0168 PF00089 Trypsin 0.0161 PF00027 Cyclic nucleotide-binding domain 0.0148 PF00989 PAS fold 0.0141 PF00102 Protein-tyrosine phosphatase 0.0122 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0121 PF00051 Kringle domain 0.0111 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0098 PF02038 ATP1G1/PLM/MAT8 family 0.0098 PF02146 Sir2 family 0.0097 PF00112 Papain family cysteine protease 0.0093 PF02185 Hr1 repeat 0.0093 PF08912 Rho Binding 0.0093 PF02060 Slow voltage-gated potassium channel 0.0092 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0090 PF08725 Integrin beta cytoplasmic domain 0.0088 PF08441 Integrin alpha 0.0081 PF02820 mbt repeat 0.0081 PF01530 Zinc finger, C2HC type 0.0081 PF00188 Cysteine-rich secretory protein family 0.0078 PF07885 Ion channel 0.0075 PF07965 Integrin beta tail domain 0.0075 PF00362 Integrin, beta chain 0.0074 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0071 PF01916 Deoxyhypusine synthase 0.0071 PF00489 Interleukin-6/G-CSF/MGF family 0.0066 PF08466 Inward rectifier potassium channel N-terminal 0.0066 PF00230 Major intrinsic protein 0.0063 PF00578 AhpC/TSA family 0.0063 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0061 PF08447 PAS fold 0.0060 PF02803 Thiolase, C-terminal domain 0.0060 PF00108 Thiolase, N-terminal domain 0.0059 PF07966 A1 Propeptide 0.0059 PF06617 M-phase inducer phosphatase 0.0059 PF00581 Rhodanese-like domain 0.0055 PF00040 Fibronectin type II domain 0.0053 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0053 PF03520 KCNQ voltage-gated potassium channel 0.0052 PF08702 Fibrinogen alpha/beta chain family 0.0052 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0052 PF03489 Saposin-like type B, region 2 0.0052 PF01323 DSBA-like thioredoxin domain 0.0045 PF00357 Integrin alpha cytoplasmic region 0.0043 PF00287 Sodium / potassium ATPase beta chain 0.0041 PF01030 Receptor L domain 0.0041 PF00757 Furin-like cysteine rich region 0.0038 PF00092 von Willebrand factor type A domain 0.0037 PF01234 NNMT/PNMT/TEMT family 0.0037 PF00026 Eukaryotic aspartyl protease 0.0036 PF00822 PMP-22/EMP/MP20/Claudin family 0.0032 PF00625 Guanylate kinase 0.0030 PF12497 Estrogen receptor beta 0.0030 PF00341 Platelet-derived growth factor (PDGF), 0.0028 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0027 PF02743 Cache domain 0.0027 PF08399 VWA N-terminal 0.0027 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0024 PF09193 Cholecystokinin A receptor, N-terminal 0.0021 PF00337 Galactoside-binding lectin 0.0018 PF12160 Fibrinogen alpha C domain 0.0017 PF00084 Sushi domain (SCR repeat), 0.0017 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0015 PF00024 PAN domain 0.0015 PF00183 Hsp90 protein 0.0015 PF00656 Caspase domain 0.0015 PF00850 Histone deacetylase domain 0.0015 PF07645 Calcium-binding EGF domain 0.0015 PF00431 CUB domain 0.0014 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0012 PF00058 Low-density lipoprotein receptor repeat class B 0.0011 PF00059 Lectin C-type domain 0.0010 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0004 PF00433 Protein kinase C terminal domain 0.0003 PF11857 Domain of unknown function (DUF3377), 0.0002 PF07992 Pyridine nucleotide-disulphide oxidoreductase SUB389 C(:C)(:N)(:N) 0.3751 PF00186 Dihydrofolate reductase 0.1994 PF00069 Protein kinase domain 0.1655 PF00478 IMP dehydrogenase / GMP reductase domain 0.1444 PF08240 Alcohol dehydrogenase GroES-like domain 0.1298 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.1285 PF01048 Phosphorylase superfamily 0.1275 PF00107 Zinc-binding dehydrogenase 0.1180 PF00106 short chain dehydrogenase 0.1089 PF00571 CBS domain 0.0836 PF00962 Adenosine/AMP deaminase 0.0783 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0783 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0781 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0781 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0781 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0655 PF00171 Aldehyde dehydrogenase family 0.0533 PF00018 SH3 domain 0.0517 PF00248 Aldo/keto reductase family 0.0494 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0494 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0450 PF02223 Thymidylate kinase 0.0442 PF00156 Phosphoribosyl transferase domain 0.0383 PF00017 SH2 domain 0.0375 PF00501 AMP-binding enzyme 0.0337 PF08919 F-actin binding 0.0285 PF01467 Cytidylyltransferase 0.0226 PF00225 Kinesin motor domain 0.0220 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0220 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0217 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0196 PF01230 HIT domain 0.0190 PF01119 DNA mismatch repair protein, C-terminal domain 0.0190 PF08676 MutL C terminal dimerisation domain 0.0190 PF02036 SCP-2 sterol transfer family 0.0190 PF00498 FHA domain 0.0190 PF12473 Kinesin protein 0.0190 PF01575 MaoC like domain 0.0190 PF00136 DNA polymerase family B 0.0190 PF08996 DNA Polymerase alpha zinc finger 0.0190 PF03104 DNA polymerase family B, exonuclease domain 0.0190 PF12423 Kinesin protein 1B 0.0189 PF00970 Oxidoreductase FAD-binding domain 0.0187 PF03949 Malic enzyme, NAD binding domain 0.0187 PF00390 Malic enzyme, N-terminal domain 0.0172 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0172 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0172 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0172 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0156 PF00931 NB-ARC domain 0.0156 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0156 PF02233 NAD(P), transhydrogenase beta subunit 0.0156 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0156 PF00400 WD domain, G-beta repeat 0.0128 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0122 PF02867 Ribonucleotide reductase, barrel domain 0.0122 PF03770 Inositol polyphosphate kinase 0.0122 PF03477 ATP cone domain 0.0122 PF00317 Ribonucleotide reductase, all-alpha domain 0.0120 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0112 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0100 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0100 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0056 PF01030 Receptor L domain 0.0056 PF00757 Furin-like cysteine rich region 0.0054 PF01268 Formate--tetrahydrofolate ligase 0.0053 PF00858 Amiloride-sensitive sodium channel 0.0036 PF00378 Enoyl-CoA hydratase/isomerase family 0.0036 PF08515 Transforming growth factor beta type I GS-motif 0.0036 PF01064 Activin types I and II receptor domain 0.0035 PF00676 Dehydrogenase E1 component 0.0035 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0021 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0015 PF00005 ABC transporter 0.0006 PF01126 Heme oxygenase 0.0004 PF02525 Flavodoxin-like fold SUB466 O=S-C-C 0.3729 PF00194 Eukaryotic-type carbonic anhydrase 0.0989 PF08403 Amino acid permease N-terminal 0.0664 PF02254 TrkA-N domain 0.0664 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0498 PF00324 Amino acid permease 0.0494 PF01007 Inward rectifier potassium channel 0.0400 PF00045 Hemopexin 0.0400 PF01471 Putative peptidoglycan binding domain 0.0372 PF00413 Matrixin 0.0327 PF00689 Cation transporting ATPase, C-terminus 0.0327 PF00690 Cation transporter/ATPase, N-terminus 0.0291 PF00122 E1-E2 ATPase 0.0287 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0279 PF09396 Thrombin light chain 0.0250 PF00702 haloacid dehalogenase-like hydrolase 0.0237 PF00664 ABC transporter transmembrane region 0.0235 PF00005 ABC transporter 0.0227 PF03098 Animal haem peroxidase 0.0210 PF01590 GAF domain 0.0188 PF00167 Fibroblast growth factor 0.0184 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0169 PF00089 Trypsin 0.0165 PF00520 Ion transport protein 0.0163 PF00027 Cyclic nucleotide-binding domain 0.0150 PF00989 PAS fold 0.0142 PF00102 Protein-tyrosine phosphatase 0.0123 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0121 PF00051 Kringle domain 0.0113 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0098 PF00112 Papain family cysteine protease 0.0096 PF02146 Sir2 family 0.0095 PF02038 ATP1G1/PLM/MAT8 family 0.0093 PF08912 Rho Binding 0.0093 PF02185 Hr1 repeat 0.0092 PF02060 Slow voltage-gated potassium channel 0.0092 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0091 PF08725 Integrin beta cytoplasmic domain 0.0089 PF08441 Integrin alpha 0.0081 PF01530 Zinc finger, C2HC type 0.0081 PF00188 Cysteine-rich secretory protein family 0.0081 PF02820 mbt repeat 0.0079 PF07885 Ion channel 0.0076 PF00362 Integrin, beta chain 0.0076 PF07965 Integrin beta tail domain 0.0075 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0072 PF00489 Interleukin-6/G-CSF/MGF family 0.0071 PF01916 Deoxyhypusine synthase 0.0067 PF08466 Inward rectifier potassium channel N-terminal 0.0067 PF00230 Major intrinsic protein 0.0063 PF00578 AhpC/TSA family 0.0063 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0062 PF08447 PAS fold 0.0061 PF00108 Thiolase, N-terminal domain 0.0061 PF02803 Thiolase, C-terminal domain 0.0060 PF00581 Rhodanese-like domain 0.0060 PF07966 A1 Propeptide 0.0060 PF06617 M-phase inducer phosphatase 0.0056 PF00040 Fibronectin type II domain 0.0053 PF08702 Fibrinogen alpha/beta chain family 0.0053 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0053 PF01323 DSBA-like thioredoxin domain 0.0053 PF03489 Saposin-like type B, region 2 0.0053 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0052 PF03520 KCNQ voltage-gated potassium channel 0.0046 PF00357 Integrin alpha cytoplasmic region 0.0043 PF00287 Sodium / potassium ATPase beta chain 0.0041 PF00757 Furin-like cysteine rich region 0.0041 PF01030 Receptor L domain 0.0038 PF01234 NNMT/PNMT/TEMT family 0.0038 PF00092 von Willebrand factor type A domain 0.0037 PF00026 Eukaryotic aspartyl protease 0.0036 PF00822 PMP-22/EMP/MP20/Claudin family 0.0032 PF00625 Guanylate kinase 0.0030 PF00341 Platelet-derived growth factor (PDGF), 0.0030 PF12497 Estrogen receptor beta 0.0029 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0027 PF02743 Cache domain 0.0027 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0027 PF08399 VWA N-terminal 0.0024 PF09193 Cholecystokinin A receptor, N-terminal 0.0021 PF00337 Galactoside-binding lectin 0.0018 PF12160 Fibrinogen alpha C domain 0.0017 PF00084 Sushi domain (SCR repeat), 0.0017 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0015 PF00850 Histone deacetylase domain 0.0015 PF07645 Calcium-binding EGF domain 0.0015 PF00431 CUB domain 0.0015 PF00656 Caspase domain 0.0015 PF00024 PAN domain 0.0015 PF00183 Hsp90 protein 0.0014 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0012 PF00058 Low-density lipoprotein receptor repeat class B 0.0011 PF00059 Lectin C-type domain 0.0010 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF00433 Protein kinase C terminal domain 0.0003 PF11857 Domain of unknown function (DUF3377), 0.0002 PF07992 Pyridine nucleotide-disulphide oxidoreductase SUB674 O=C-C=C-N 0.3609 PF00204 DNA gyrase B 0.3609 PF08070 DTHCT (NUC029), region 0.3609 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1793 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.1366 PF00102 Protein-tyrosine phosphatase 0.0916 PF01048 Phosphorylase superfamily 0.0883 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0588 PF00303 Thymidylate synthase 0.0532 PF01590 GAF domain 0.0502 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0451 PF02525 Flavodoxin-like fold 0.0429 PF00576 HIUase/Transthyretin family 0.0427 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0427 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0427 PF00533 BRCA1 C Terminus (BRCT), domain 0.0427 PF05406 WGR domain 0.0427 PF08063 PADR1 (NUC008), domain 0.0415 PF00821 Phosphoenolpyruvate carboxykinase 0.0406 PF01467 Cytidylyltransferase 0.0401 PF01268 Formate--tetrahydrofolate ligase 0.0381 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0381 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0360 PF01808 AICARFT/IMPCHase bienzyme 0.0345 PF00107 Zinc-binding dehydrogenase 0.0342 PF00106 short chain dehydrogenase 0.0332 PF08240 Alcohol dehydrogenase GroES-like domain 0.0311 PF00248 Aldo/keto reductase family 0.0310 PF00071 Ras family 0.0285 PF00858 Amiloride-sensitive sodium channel 0.0272 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0253 PF00186 Dihydrofolate reductase 0.0247 PF01652 Eukaryotic initiation factor 4E 0.0241 PF02223 Thymidylate kinase 0.0229 PF02142 MGS-like domain 0.0228 PF01370 NAD dependent epimerase/dehydratase family 0.0227 PF00183 Hsp90 protein 0.0209 PF03098 Animal haem peroxidase 0.0202 PF00227 Proteasome subunit 0.0194 PF03024 Folate receptor family 0.0178 PF00464 Serine hydroxymethyltransferase 0.0171 PF01571 Aminomethyltransferase folate-binding domain 0.0171 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0168 PF00551 Formyl transferase 0.0163 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0163 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0149 PF00171 Aldehyde dehydrogenase family 0.0148 PF02267 ADP-ribosyl cyclase 0.0144 PF01575 MaoC like domain 0.0144 PF02036 SCP-2 sterol transfer family 0.0142 PF00025 ADP-ribosylation factor family 0.0135 PF00493 MCM2/3/5 family 0.0123 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0123 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0123 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0120 PF00305 Lipoxygenase 0.0119 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0119 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0118 PF01061 ABC-2 type transporter 0.0111 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0111 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0101 PF02233 NAD(P), transhydrogenase beta subunit 0.0087 PF08919 F-actin binding 0.0086 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0084 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0079 PF00018 SH3 domain 0.0079 PF00822 PMP-22/EMP/MP20/Claudin family 0.0079 PF02219 Methylenetetrahydrofolate reductase 0.0073 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0073 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0072 PF01731 Arylesterase 0.0071 PF00017 SH2 domain 0.0071 PF01180 Dihydroorotate dehydrogenase 0.0070 PF00999 Sodium/hydrogen exchanger family 0.0069 PF02059 Interleukin-3 0.0066 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0066 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0062 PF00028 Cadherin domain 0.0062 PF03360 Glycosyltransferase family 43 0.0059 PF12491 Apolipoprotein B100 C terminal 0.0059 PF06448 Domain of Unknown Function (DUF1081), 0.0056 PF00571 CBS domain 0.0055 PF00478 IMP dehydrogenase / GMP reductase domain 0.0054 PF00550 Phosphopantetheine attachment site 0.0051 PF01023 S-100/ICaBP type calcium binding domain 0.0046 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0046 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0043 PF02769 AIR synthase related protein, C-terminal domain 0.0043 PF00586 AIR synthase related protein, N-terminal domain 0.0042 PF02911 Formyl transferase, C-terminal domain 0.0040 PF03949 Malic enzyme, NAD binding domain 0.0040 PF10420 Cytokine interleukin-12p40 C-terminus 0.0040 PF00390 Malic enzyme, N-terminal domain 0.0039 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0039 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0034 PF00377 Prion/Doppel alpha-helical domain 0.0034 PF07722 Peptidase C26 0.0030 PF01227 GTP cyclohydrolase I 0.0030 PF00536 SAM domain (Sterile alpha motif), 0.0030 PF01404 Ephrin receptor ligand binding domain 0.0029 PF01347 Lipoprotein amino terminal region 0.0024 PF00264 Common central domain of tyrosinase 0.0023 PF08403 Amino acid permease N-terminal 0.0022 PF00341 Platelet-derived growth factor (PDGF), 0.0021 PF00654 Voltage gated chloride channel 0.0020 PF00868 Transglutaminase family 0.0020 PF01841 Transglutaminase-like superfamily 0.0020 PF00656 Caspase domain 0.0020 PF00927 Transglutaminase family, C-terminal ig like domain 0.0017 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0017 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0012 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0007 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0007 PF00340 Interleukin-1 / 18 0.0007 PF02394 Interleukin-1 propeptide 0.0007 PF00676 Dehydrogenase E1 component 0.0006 PF01916 Deoxyhypusine synthase 0.0003 PF00385 chromo (CHRromatin Organisation MOdifier), domain SUB414 S(~C)(~H) 0.3608 PF02798 Glutathione S-transferase, N-terminal domain 0.3528 PF00043 Glutathione S-transferase, C-terminal domain 0.2137 PF00255 Glutathione peroxidase 0.1721 PF05649 Peptidase family M13 0.1721 PF01431 Peptidase family M13 0.1498 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.1207 PF01124 MAPEG family 0.1119 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.1064 PF00091 Tubulin/FtsZ family, GTPase domain 0.1064 PF03953 Tubulin C-terminal domain 0.1036 PF01401 Angiotensin-converting enzyme 0.0978 PF09396 Thrombin light chain 0.0947 PF03199 Eukaryotic glutathione synthase 0.0947 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0727 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0718 PF01323 DSBA-like thioredoxin domain 0.0650 PF00656 Caspase domain 0.0636 PF08983 Domain of unknown function (DUF1856), 0.0603 PF00303 Thymidylate synthase 0.0560 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0527 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0521 PF00462 Glutaredoxin 0.0493 PF07722 Peptidase C26 0.0431 PF01406 tRNA synthetases class I (C), catalytic domain 0.0415 PF05995 Cysteine dioxygenase type I 0.0411 PF01019 Gamma-glutamyltranspeptidase 0.0411 PF00756 Putative esterase 0.0368 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0368 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0354 PF00619 Caspase recruitment domain 0.0343 PF03074 Glutamate-cysteine ligase 0.0240 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0235 PF00439 Bromodomain 0.0235 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0209 PF00581 Rhodanese-like domain 0.0209 PF06617 M-phase inducer phosphatase 0.0189 PF03002 Somatostatin/Cortistatin family 0.0186 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0180 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0160 PF00085 Thioredoxin 0.0157 PF08833 Axin beta-catenin binding domain 0.0157 PF00806 Pumilio-family RNA binding repeat 0.0157 PF00778 DIX domain 0.0152 PF00822 PMP-22/EMP/MP20/Claudin family 0.0139 PF00265 Thymidine kinase 0.0134 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0134 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0114 PF00342 Phosphoglucose isomerase 0.0113 PF00931 NB-ARC domain 0.0113 PF00400 WD domain, G-beta repeat 0.0083 PF02793 Hormone receptor domain 0.0083 PF00002 7 transmembrane receptor (Secretin family), 0.0062 PF01268 Formate--tetrahydrofolate ligase 0.0036 PF02769 AIR synthase related protein, C-terminal domain 0.0036 PF00586 AIR synthase related protein, N-terminal domain 0.0034 PF10420 Cytokine interleukin-12p40 C-terminus 0.0029 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0029 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0021 PF00045 Hemopexin 0.0021 PF01471 Putative peptidoglycan binding domain 0.0019 PF00108 Thiolase, N-terminal domain 0.0019 PF02803 Thiolase, C-terminal domain 0.0005 PF00551 Formyl transferase SUB35 >= 2 S 0.3560 PF00194 Eukaryotic-type carbonic anhydrase 0.1101 PF08403 Amino acid permease N-terminal 0.1004 PF02254 TrkA-N domain 0.1004 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0540 PF00324 Amino acid permease 0.0404 PF00689 Cation transporting ATPase, C-terminus 0.0404 PF00690 Cation transporter/ATPase, N-terminus 0.0359 PF00122 E1-E2 ATPase 0.0325 PF01007 Inward rectifier potassium channel 0.0314 PF00702 haloacid dehalogenase-like hydrolase 0.0249 PF09396 Thrombin light chain 0.0227 PF00045 Hemopexin 0.0227 PF01471 Putative peptidoglycan binding domain 0.0213 PF00102 Protein-tyrosine phosphatase 0.0211 PF00413 Matrixin 0.0192 PF08702 Fibrinogen alpha/beta chain family 0.0192 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0185 PF02146 Sir2 family 0.0179 PF00520 Ion transport protein 0.0145 PF00273 Serum albumin family 0.0145 PF00167 Fibroblast growth factor 0.0139 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0125 PF01916 Deoxyhypusine synthase 0.0120 PF10420 Cytokine interleukin-12p40 C-terminus 0.0104 PF12160 Fibrinogen alpha C domain 0.0103 PF00043 Glutathione S-transferase, C-terminal domain 0.0101 PF02038 ATP1G1/PLM/MAT8 family 0.0101 PF02798 Glutathione S-transferase, N-terminal domain 0.0099 PF00108 Thiolase, N-terminal domain 0.0099 PF02803 Thiolase, C-terminal domain 0.0090 PF00040 Fibronectin type II domain 0.0086 PF00664 ABC transporter transmembrane region 0.0084 PF00051 Kringle domain 0.0077 PF00089 Trypsin 0.0077 PF08983 Domain of unknown function (DUF1856), 0.0074 PF00005 ABC transporter 0.0070 PF03098 Animal haem peroxidase 0.0063 PF00069 Protein kinase domain 0.0061 PF01459 Eukaryotic porin 0.0060 PF01590 GAF domain 0.0058 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0056 PF00091 Tubulin/FtsZ family, GTPase domain 0.0056 PF03953 Tubulin C-terminal domain 0.0053 PF00079 Serpin (serine protease inhibitor), 0.0046 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0043 PF00186 Dihydrofolate reductase 0.0040 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0039 PF00001 7 transmembrane receptor (rhodopsin family), 0.0036 PF01068 ATP dependent DNA ligase domain 0.0036 PF04679 ATP dependent DNA ligase C terminal region 0.0033 PF00024 PAN domain 0.0032 PF00027 Cyclic nucleotide-binding domain 0.0031 PF11857 Domain of unknown function (DUF3377), 0.0030 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0029 PF00989 PAS fold 0.0029 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0028 PF02793 Hormone receptor domain 0.0028 PF00002 7 transmembrane receptor (Secretin family), 0.0026 PF00854 POT family 0.0025 PF00230 Major intrinsic protein 0.0024 PF02185 Hr1 repeat 0.0024 PF08466 Inward rectifier potassium channel N-terminal 0.0024 PF08912 Rho Binding 0.0023 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0023 PF08441 Integrin alpha 0.0022 PF00405 Transferrin 0.0022 PF08725 Integrin beta cytoplasmic domain 0.0022 PF02060 Slow voltage-gated potassium channel 0.0021 PF00112 Papain family cysteine protease 0.0020 PF00188 Cysteine-rich secretory protein family 0.0019 PF01323 DSBA-like thioredoxin domain 0.0018 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0017 PF04055 Radical SAM superfamily 0.0017 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0017 PF06617 M-phase inducer phosphatase 0.0017 PF07965 Integrin beta tail domain 0.0017 PF08833 Axin beta-catenin binding domain 0.0017 PF00581 Rhodanese-like domain 0.0017 PF00778 DIX domain 0.0017 PF00362 Integrin, beta chain 0.0017 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0017 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0017 PF00578 AhpC/TSA family 0.0017 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0016 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0016 PF01530 Zinc finger, C2HC type 0.0016 PF02820 mbt repeat 0.0016 PF01731 Arylesterase 0.0015 PF00020 TNFR/NGFR cysteine-rich region 0.0015 PF07885 Ion channel 0.0014 PF00156 Phosphoribosyl transferase domain 0.0014 PF00489 Interleukin-6/G-CSF/MGF family 0.0014 PF03489 Saposin-like type B, region 2 0.0013 PF00478 IMP dehydrogenase / GMP reductase domain 0.0013 PF00059 Lectin C-type domain 0.0013 PF00255 Glutathione peroxidase 0.0012 PF12497 Estrogen receptor beta 0.0012 PF02806 Alpha amylase, C-terminal all-beta domain 0.0012 PF08447 PAS fold 0.0012 PF01234 NNMT/PNMT/TEMT family 0.0012 PF00357 Integrin alpha cytoplasmic region 0.0012 PF07966 A1 Propeptide 0.0011 PF01770 Reduced folate carrier 0.0011 PF01369 Sec7 domain 0.0011 PF00265 Thymidine kinase 0.0011 PF03099 Biotin/lipoate A/B protein ligase family 0.0011 PF00962 Adenosine/AMP deaminase 0.0010 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0010 PF00084 Sushi domain (SCR repeat), 0.0010 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0010 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0010 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0010 PF03520 KCNQ voltage-gated potassium channel 0.0010 PF02772 S-adenosylmethionine synthetase, central domain 0.0010 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0010 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0010 PF09193 Cholecystokinin A receptor, N-terminal 0.0009 PF00656 Caspase domain 0.0009 PF00128 Alpha amylase, catalytic domain 0.0009 PF10397 Adenylosuccinate lyase C-terminus 0.0009 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0008 PF00287 Sodium / potassium ATPase beta chain 0.0008 PF01030 Receptor L domain 0.0008 PF00757 Furin-like cysteine rich region 0.0007 PF00092 von Willebrand factor type A domain 0.0007 PF00026 Eukaryotic aspartyl protease 0.0007 PF00822 PMP-22/EMP/MP20/Claudin family 0.0006 PF00625 Guanylate kinase 0.0006 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0006 PF00058 Low-density lipoprotein receptor repeat class B 0.0006 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0006 PF01055 Glycosyl hydrolases family 31 0.0006 PF01124 MAPEG family 0.0006 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0006 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0006 PF00088 Trefoil (P-type), domain 0.0006 PF00474 Sodium:solute symporter family 0.0006 PF02785 Biotin carboxylase C-terminal domain 0.0006 PF00341 Platelet-derived growth factor (PDGF), 0.0005 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0005 PF00364 Biotin-requiring enzyme 0.0005 PF01039 Carboxyl transferase domain 0.0005 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF00615 Regulator of G protein signaling domain 0.0005 PF01370 NAD dependent epimerase/dehydratase family 0.0005 PF08399 VWA N-terminal 0.0005 PF00245 Alkaline phosphatase 0.0005 PF02743 Cache domain 0.0005 PF04321 RmlD substrate binding domain 0.0005 PF01462 Leucine rich repeat N-terminal domain 0.0005 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0005 PF00958 GMP synthase C terminal domain 0.0004 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0004 PF00337 Galactoside-binding lectin 0.0004 PF02460 Patched family 0.0004 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0004 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0004 PF07645 Calcium-binding EGF domain 0.0004 PF00431 CUB domain 0.0004 PF02180 Bcl-2 homology region 4 0.0004 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0004 PF01431 Peptidase family M13 0.0004 PF03414 Glycosyltransferase family 6 0.0004 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0004 PF00206 Lyase 0.0004 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0004 PF05649 Peptidase family M13 0.0004 PF02260 FATC domain 0.0004 PF08771 Rapamycin binding domain 0.0004 PF02259 FAT domain 0.0004 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0004 PF02574 Homocysteine S-methyltransferase 0.0003 PF01641 SelR domain 0.0003 PF00850 Histone deacetylase domain 0.0003 PF03073 TspO/MBR family 0.0003 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0003 PF01406 tRNA synthetases class I (C), catalytic domain 0.0003 PF00439 Bromodomain 0.0003 PF03770 Inositol polyphosphate kinase 0.0003 PF09334 tRNA synthetases class I (M), 0.0003 PF01835 MG2 domain 0.0003 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0003 PF01652 Eukaryotic initiation factor 4E 0.0003 PF07678 A-macroglobulin complement component 0.0003 PF07677 A-macroglobulin receptor 0.0003 PF08326 Acetyl-CoA carboxylase, central region 0.0003 PF03062 MBOAT family 0.0003 PF00183 Hsp90 protein 0.0002 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0002 PF00248 Aldo/keto reductase family 0.0002 PF00169 PH domain 0.0002 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0002 PF02233 NAD(P), transhydrogenase beta subunit 0.0002 PF02267 ADP-ribosyl cyclase 0.0001 PF08919 F-actin binding 0.0001 PF01433 Peptidase family M1 0.0001 PF01122 Eukaryotic cobalamin-binding protein 0.0001 PF02223 Thymidylate kinase 0.0001 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0001 PF00171 Aldehyde dehydrogenase family 0.0001 PF00406 Adenylate kinase 0.0001 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0001 PF00779 BTK motif 0.0001 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0001 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0001 PF00151 Lipase 0.0001 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0001 PF05995 Cysteine dioxygenase type I 0.0001 PF00378 Enoyl-CoA hydratase/isomerase family 0.0001 PF00106 short chain dehydrogenase 0.0001 PF05193 Peptidase M16 inactive domain 0.0001 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0001 PF03360 Glycosyltransferase family 43 0.0001 PF00675 Insulinase (Peptidase family M16), 0.0001 PF00433 Protein kinase C terminal domain 0.0001 PF00531 Death domain 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF03199 Eukaryotic glutathione synthase SUB750 Nc1cc(N)ccc1 0.3550 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.3550 PF00204 DNA gyrase B 0.3550 PF08070 DTHCT (NUC029), region 0.1612 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0442 PF00273 Serum albumin family 0.0405 PF03953 Tubulin C-terminal domain 0.0405 PF00091 Tubulin/FtsZ family, GTPase domain 0.0314 PF00102 Protein-tyrosine phosphatase 0.0302 PF00576 HIUase/Transthyretin family 0.0227 PF00005 ABC transporter 0.0226 PF09396 Thrombin light chain 0.0226 PF00405 Transferrin 0.0213 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0202 PF01061 ABC-2 type transporter 0.0165 PF07884 Vitamin K epoxide reductase family 0.0162 PF00664 ABC transporter transmembrane region 0.0152 PF00754 F5/8 type C domain 0.0142 PF00017 SH2 domain 0.0138 PF08919 F-actin binding 0.0130 PF03098 Animal haem peroxidase 0.0123 PF01735 Lysophospholipase catalytic domain 0.0122 PF00018 SH3 domain 0.0118 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0104 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0103 PF01187 Macrophage migration inhibitory factor (MIF), 0.0099 PF00305 Lipoxygenase 0.0097 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0095 PF03957 Jun-like transcription factor 0.0095 PF00079 Serpin (serine protease inhibitor), 0.0092 PF03171 2OG-Fe(II), oxygenase superfamily 0.0091 PF00291 Pyridoxal-phosphate dependent enzyme 0.0087 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0083 PF00656 Caspase domain 0.0082 PF01477 PLAT/LH2 domain 0.0081 PF00266 Aminotransferase class-V 0.0079 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0079 PF03949 Malic enzyme, NAD binding domain 0.0079 PF00390 Malic enzyme, N-terminal domain 0.0078 PF08771 Rapamycin binding domain 0.0078 PF02260 FATC domain 0.0078 PF02259 FAT domain 0.0078 PF00043 Glutathione S-transferase, C-terminal domain 0.0077 PF02155 Glucocorticoid receptor 0.0077 PF00168 C2 domain 0.0074 PF02798 Glutathione S-transferase, N-terminal domain 0.0072 PF00493 MCM2/3/5 family 0.0071 PF02394 Interleukin-1 propeptide 0.0071 PF00340 Interleukin-1 / 18 0.0070 PF00229 TNF(Tumour Necrosis Factor), family 0.0067 PF01023 S-100/ICaBP type calcium binding domain 0.0067 PF01347 Lipoprotein amino terminal region 0.0066 PF00341 Platelet-derived growth factor (PDGF), 0.0063 PF01180 Dihydroorotate dehydrogenase 0.0061 PF00108 Thiolase, N-terminal domain 0.0061 PF02803 Thiolase, C-terminal domain 0.0060 PF00155 Aminotransferase class I and II 0.0059 PF00698 Acyl transferase domain 0.0059 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0059 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0059 PF00975 Thioesterase domain 0.0059 PF08659 KR domain 0.0058 PF00040 Fibronectin type II domain 0.0058 PF00271 Helicase conserved C-terminal domain 0.0057 PF00377 Prion/Doppel alpha-helical domain 0.0057 PF00989 PAS fold 0.0056 PF00085 Thioredoxin 0.0055 PF01202 Shikimate kinase 0.0054 PF00071 Ras family 0.0054 PF00170 bZIP transcription factor 0.0052 PF02793 Hormone receptor domain 0.0052 PF00002 7 transmembrane receptor (Secretin family), 0.0052 PF02059 Interleukin-3 0.0051 PF00191 Annexin 0.0051 PF00176 SNF2 family N-terminal domain 0.0051 PF12491 Apolipoprotein B100 C terminal 0.0051 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0051 PF06448 Domain of Unknown Function (DUF1081), 0.0049 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0048 PF01391 Collagen triple helix repeat (20 copies), 0.0047 PF00755 Choline/Carnitine o-acyltransferase 0.0045 PF03062 MBOAT family 0.0044 PF00027 Cyclic nucleotide-binding domain 0.0044 PF02525 Flavodoxin-like fold 0.0043 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0042 PF04679 ATP dependent DNA ligase C terminal region 0.0042 PF01068 ATP dependent DNA ligase domain 0.0042 PF00058 Low-density lipoprotein receptor repeat class B 0.0041 PF00781 Diacylglycerol kinase catalytic domain 0.0041 PF01731 Arylesterase 0.0041 PF03034 Phosphatidyl serine synthase 0.0041 PF00094 von Willebrand factor type D domain 0.0041 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0041 PF00609 Diacylglycerol kinase accessory domain 0.0041 PF02824 TGS domain 0.0041 PF02025 Interleukin 5 0.0041 PF08742 C8 domain 0.0040 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0040 PF01753 MYND finger 0.0040 PF08429 PLU-1-like protein 0.0040 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0040 PF02180 Bcl-2 homology region 4 0.0040 PF00274 Fructose-bisphosphate aldolase class-I 0.0040 PF00628 PHD-finger 0.0040 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0040 PF02373 JmjC domain 0.0040 PF02375 jmjN domain 0.0040 PF01388 ARID/BRIGHT DNA binding domain 0.0040 PF02928 C5HC2 zinc finger 0.0040 PF00860 Permease family 0.0039 PF00342 Phosphoglucose isomerase 0.0039 PF00183 Hsp90 protein 0.0038 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0038 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0036 PF00464 Serine hydroxymethyltransferase 0.0036 PF01596 O-methyltransferase 0.0035 PF00057 Low-density lipoprotein receptor domain class A 0.0034 PF01429 Methyl-CpG binding domain 0.0034 PF01425 Amidase 0.0033 PF00654 Voltage gated chloride channel 0.0033 PF00343 Carbohydrate phosphorylase 0.0032 PF03473 MOSC domain 0.0032 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0032 PF03476 MOSC N-terminal beta barrel domain 0.0031 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0030 PF00186 Dihydrofolate reductase 0.0030 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0030 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0030 PF00717 Peptidase S24-like 0.0030 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0030 PF01437 Plexin repeat 0.0030 PF01833 IPT/TIG domain 0.0030 PF01403 Sema domain 0.0029 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0029 PF07647 SAM domain (Sterile alpha motif), 0.0029 PF02403 Seryl-tRNA synthetase N-terminal domain 0.0029 PF02666 Phosphatidylserine decarboxylase 0.0029 PF00270 DEAD/DEAH box helicase 0.0029 PF03351 DOMON domain 0.0029 PF00246 Zinc carboxypeptidase 0.0029 PF09193 Cholecystokinin A receptor, N-terminal 0.0029 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0029 PF11404 Potassium voltage-gated channel 0.0029 PF01130 CD36 family 0.0029 PF00969 Class II histocompatibility antigen, beta domain 0.0028 PF00554 Rel homology domain (RHD), 0.0027 PF00550 Phosphopantetheine attachment site 0.0026 PF03623 Focal adhesion targeting region 0.0026 PF00051 Kringle domain 0.0024 PF02898 Nitric oxide synthase, oxygenase domain 0.0023 PF03360 Glycosyltransferase family 43 0.0022 PF00294 pfkB family carbohydrate kinase 0.0022 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.0021 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0021 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0020 PF02347 Glycine cleavage system P-protein 0.0020 PF01168 Alanine racemase, N-terminal domain 0.0020 PF01212 Beta-eliminating lyase 0.0020 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0019 PF07690 Major Facilitator Superfamily 0.0018 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 0.0018 PF00373 FERM central domain 0.0017 PF00020 TNFR/NGFR cysteine-rich region 0.0017 PF00151 Lipase 0.0016 PF00019 Transforming growth factor beta like domain 0.0016 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0016 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0016 PF00714 Interferon gamma 0.0016 PF00028 Cadherin domain 0.0016 PF00688 TGF-beta propeptide 0.0016 PF00489 Interleukin-6/G-CSF/MGF family 0.0016 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0015 PF00682 HMGL-like 0.0013 PF00202 Aminotransferase class-III 0.0012 PF01462 Leucine rich repeat N-terminal domain 0.0012 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0012 PF00533 BRCA1 C Terminus (BRCT), domain 0.0012 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0012 PF05406 WGR domain 0.0012 PF08063 PADR1 (NUC008), domain 0.0011 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0010 PF00619 Caspase recruitment domain 0.0009 PF00571 CBS domain 0.0009 PF00787 PX domain 0.0008 PF04961 Formiminotransferase-cyclodeaminase 0.0008 PF00432 Prenyltransferase and squalene oxidase repeat 0.0008 PF03129 Anticodon binding domain 0.0008 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0008 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0008 PF02460 Patched family 0.0008 PF00792 Phosphoinositide 3-kinase C2 0.0008 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0008 PF00794 PI3-kinase family, ras-binding domain 0.0008 PF02971 Formiminotransferase domain 0.0008 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0007 PF00622 SPRY domain 0.0007 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0007 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0007 PF00024 PAN domain 0.0007 PF01067 Calpain large subunit, domain III 0.0007 PF00648 Calpain family cysteine protease 0.0006 PF01365 RIH domain 0.0006 PF00354 Pentaxin family 0.0006 PF02210 Laminin G domain 0.0006 PF02815 MIR domain 0.0006 PF04756 OST3 / OST6 family 0.0006 PF06459 Ryanodine Receptor TM 4-6 0.0006 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0006 PF02026 RyR domain 0.0006 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0006 PF08454 RyR and IP3R Homology associated 0.0006 PF03024 Folate receptor family 0.0006 PF00074 Pancreatic ribonuclease 0.0006 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0006 PF07648 Kazal-type serine protease inhibitor domain 0.0006 PF08709 Inositol 1,4,5-trisphosphate/ryanodine receptor 0.0005 PF00433 Protein kinase C terminal domain 0.0005 PF02758 PAAD/DAPIN/Pyrin domain 0.0005 PF00227 Proteasome subunit 0.0004 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0004 PF00025 ADP-ribosylation factor family 0.0003 PF00067 Cytochrome P450 0.0003 PF00089 Trypsin 0.0002 PF08725 Integrin beta cytoplasmic domain 0.0002 PF00531 Death domain 0.0002 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0001 PF00675 Insulinase (Peptidase family M16), 0.0001 PF05193 Peptidase M16 inactive domain SUB306 N-S 0.3441 PF00194 Eukaryotic-type carbonic anhydrase 0.1022 PF08403 Amino acid permease N-terminal 0.0792 PF02254 TrkA-N domain 0.0792 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0469 PF00324 Amino acid permease 0.0328 PF00091 Tubulin/FtsZ family, GTPase domain 0.0328 PF03953 Tubulin C-terminal domain 0.0292 PF01471 Putative peptidoglycan binding domain 0.0292 PF00045 Hemopexin 0.0274 PF01007 Inward rectifier potassium channel 0.0272 PF00689 Cation transporting ATPase, C-terminus 0.0272 PF00690 Cation transporter/ATPase, N-terminus 0.0267 PF00413 Matrixin 0.0240 PF00001 7 transmembrane receptor (rhodopsin family), 0.0235 PF00122 E1-E2 ATPase 0.0224 PF02798 Glutathione S-transferase, N-terminal domain 0.0223 PF00043 Glutathione S-transferase, C-terminal domain 0.0209 PF00102 Protein-tyrosine phosphatase 0.0191 PF00702 haloacid dehalogenase-like hydrolase 0.0138 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0120 PF01590 GAF domain 0.0119 PF09396 Thrombin light chain 0.0115 PF00520 Ion transport protein 0.0108 PF02038 ATP1G1/PLM/MAT8 family 0.0104 PF00664 ABC transporter transmembrane region 0.0095 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0091 PF08983 Domain of unknown function (DUF1856), 0.0089 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0086 PF00005 ABC transporter 0.0085 PF00156 Phosphoribosyl transferase domain 0.0078 PF00854 POT family 0.0078 PF00255 Glutathione peroxidase 0.0077 PF00478 IMP dehydrogenase / GMP reductase domain 0.0070 PF00962 Adenosine/AMP deaminase 0.0070 PF01770 Reduced folate carrier 0.0063 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0063 PF02060 Slow voltage-gated potassium channel 0.0063 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0061 PF02146 Sir2 family 0.0060 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0060 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0060 PF02772 S-adenosylmethionine synthetase, central domain 0.0058 PF03098 Animal haem peroxidase 0.0055 PF10397 Adenylosuccinate lyase C-terminus 0.0054 PF00167 Fibroblast growth factor 0.0052 PF01068 ATP dependent DNA ligase domain 0.0052 PF04679 ATP dependent DNA ligase C terminal region 0.0052 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0043 PF00108 Thiolase, N-terminal domain 0.0043 PF02803 Thiolase, C-terminal domain 0.0041 PF12497 Estrogen receptor beta 0.0039 PF11857 Domain of unknown function (DUF3377), 0.0039 PF02785 Biotin carboxylase C-terminal domain 0.0038 PF02185 Hr1 repeat 0.0038 PF08912 Rho Binding 0.0036 PF01124 MAPEG family 0.0035 PF00656 Caspase domain 0.0034 PF08441 Integrin alpha 0.0033 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0032 PF00245 Alkaline phosphatase 0.0032 PF04321 RmlD substrate binding domain 0.0030 PF01039 Carboxyl transferase domain 0.0030 PF00002 7 transmembrane receptor (Secretin family), 0.0030 PF02793 Hormone receptor domain 0.0029 PF00958 GMP synthase C terminal domain 0.0029 PF01323 DSBA-like thioredoxin domain 0.0029 PF00364 Biotin-requiring enzyme 0.0029 PF08725 Integrin beta cytoplasmic domain 0.0025 PF01431 Peptidase family M13 0.0025 PF05649 Peptidase family M13 0.0024 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0023 PF00206 Lyase 0.0023 PF03520 KCNQ voltage-gated potassium channel 0.0023 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0023 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0022 PF02574 Homocysteine S-methyltransferase 0.0021 PF00273 Serum albumin family 0.0019 PF00357 Integrin alpha cytoplasmic region 0.0017 PF00362 Integrin, beta chain 0.0017 PF07965 Integrin beta tail domain 0.0017 PF03099 Biotin/lipoate A/B protein ligase family 0.0016 PF01406 tRNA synthetases class I (C), catalytic domain 0.0016 PF01641 SelR domain 0.0016 PF08326 Acetyl-CoA carboxylase, central region 0.0016 PF09334 tRNA synthetases class I (M), 0.0015 PF06617 M-phase inducer phosphatase 0.0015 PF00581 Rhodanese-like domain 0.0014 PF01916 Deoxyhypusine synthase 0.0012 PF10420 Cytokine interleukin-12p40 C-terminus 0.0012 PF01234 NNMT/PNMT/TEMT family 0.0012 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0011 PF00112 Papain family cysteine protease 0.0011 PF00051 Kringle domain 0.0010 PF00230 Major intrinsic protein 0.0008 PF00474 Sodium:solute symporter family 0.0006 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0006 PF03199 Eukaryotic glutathione synthase 0.0006 PF05995 Cysteine dioxygenase type I 0.0005 PF08919 F-actin binding 0.0003 PF00778 DIX domain 0.0003 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0003 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0003 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0003 PF04055 Radical SAM superfamily 0.0003 PF08833 Axin beta-catenin binding domain 0.0002 PF01731 Arylesterase 0.0002 PF00020 TNFR/NGFR cysteine-rich region 0.0001 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF02493 MORN repeat 0.0001 PF00806 Pumilio-family RNA binding repeat 0.0001 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0001 PF01019 Gamma-glutamyltranspeptidase 0.0001 PF08466 Inward rectifier potassium channel N-terminal 0.0001 PF00462 Glutaredoxin 0.0001 PF08447 PAS fold 0.0001 PF01835 MG2 domain 0.0001 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0001 PF01625 Peptide methionine sulfoxide reductase 0.0001 PF02237 Biotin protein ligase C terminal domain 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF00756 Putative esterase 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0001 PF01244 Membrane dipeptidase (Peptidase family M19), 0.0001 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF02189 Immunoreceptor tyrosine-based activation motif 0.0001 PF00439 Bromodomain 0.0001 PF00856 SET domain 0.0001 PF01733 Nucleoside transporter SUB479 S-C=N-[#1] 0.3424 PF00689 Cation transporting ATPase, C-terminus 0.3424 PF00690 Cation transporter/ATPase, N-terminus 0.3124 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.3059 PF00122 E1-E2 ATPase 0.2780 PF00702 haloacid dehalogenase-like hydrolase 0.0754 PF00287 Sodium / potassium ATPase beta chain 0.0697 PF00091 Tubulin/FtsZ family, GTPase domain 0.0697 PF03953 Tubulin C-terminal domain 0.0539 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0531 PF00146 NADH dehydrogenase 0.0514 PF00194 Eukaryotic-type carbonic anhydrase 0.0279 PF02214 K+ channel tetramerisation domain 0.0216 PF02254 TrkA-N domain 0.0216 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0216 PF00230 Major intrinsic protein 0.0199 PF00258 Flavodoxin 0.0199 PF00667 FAD binding domain 0.0196 PF00175 Oxidoreductase NAD-binding domain 0.0194 PF00102 Protein-tyrosine phosphatase 0.0189 PF02898 Nitric oxide synthase, oxygenase domain 0.0188 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0188 PF00017 SH2 domain 0.0180 PF00018 SH3 domain 0.0173 PF12497 Estrogen receptor beta 0.0150 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0148 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0148 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0144 PF01068 ATP dependent DNA ligase domain 0.0144 PF04679 ATP dependent DNA ligase C terminal region 0.0138 PF01770 Reduced folate carrier 0.0132 PF00631 GGL domain 0.0132 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0131 PF00478 IMP dehydrogenase / GMP reductase domain 0.0126 PF08919 F-actin binding 0.0123 PF03073 TspO/MBR family 0.0123 PF01122 Eukaryotic cobalamin-binding protein 0.0120 PF00962 Adenosine/AMP deaminase 0.0116 PF02888 Calmodulin binding domain 0.0116 PF03530 Calcium-activated SK potassium channel 0.0109 PF00520 Ion transport protein 0.0101 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0093 PF00536 SAM domain (Sterile alpha motif), 0.0093 PF10397 Adenylosuccinate lyase C-terminus 0.0093 PF01404 Ephrin receptor ligand binding domain 0.0090 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0090 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0089 PF00854 POT family 0.0089 PF00273 Serum albumin family 0.0087 PF01642 Methylmalonyl-CoA mutase 0.0087 PF03308 ArgK protein 0.0087 PF01923 Cobalamin adenosyltransferase 0.0084 PF00156 Phosphoribosyl transferase domain 0.0080 PF02310 B12 binding domain 0.0079 PF01687 Riboflavin kinase 0.0077 PF00958 GMP synthase C terminal domain 0.0066 PF00794 PI3-kinase family, ras-binding domain 0.0066 PF00792 Phosphoinositide 3-kinase C2 0.0066 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0065 PF02864 STAT protein, DNA binding domain 0.0065 PF02865 STAT protein, protein interaction domain 0.0065 PF01017 STAT protein, all-alpha domain 0.0059 PF00206 Lyase 0.0049 PF00060 Ligand-gated ion channel 0.0047 PF08403 Amino acid permease N-terminal 0.0044 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0043 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0042 PF01437 Plexin repeat 0.0042 PF01833 IPT/TIG domain 0.0042 PF02441 Flavoprotein 0.0042 PF00191 Annexin 0.0042 PF01403 Sema domain 0.0041 PF00489 Interleukin-6/G-CSF/MGF family 0.0039 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0039 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0039 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0038 PF00571 CBS domain 0.0037 PF00654 Voltage gated chloride channel 0.0036 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0036 PF07885 Ion channel 0.0036 PF00245 Alkaline phosphatase 0.0036 PF08377 MAP2/Tau projection domain 0.0035 PF00576 HIUase/Transthyretin family 0.0034 PF00970 Oxidoreductase FAD-binding domain 0.0033 PF00459 Inositol monophosphatase family 0.0033 PF00069 Protein kinase domain 0.0032 PF00709 Adenylosuccinate synthetase 0.0031 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0030 PF00405 Transferrin 0.0030 PF00625 Guanylate kinase 0.0029 PF00117 Glutamine amidotransferase class-I 0.0027 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0027 PF01835 MG2 domain 0.0027 PF07678 A-macroglobulin complement component 0.0027 PF07677 A-macroglobulin receptor 0.0026 PF05406 WGR domain 0.0026 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0026 PF00809 Pterin binding enzyme 0.0026 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0026 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0026 PF02607 B12 binding domain 0.0026 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0026 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0026 PF00533 BRCA1 C Terminus (BRCT), domain 0.0026 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0026 PF08063 PADR1 (NUC008), domain 0.0025 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0025 PF02196 Raf-like Ras-binding domain 0.0024 PF01007 Inward rectifier potassium channel 0.0024 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0023 PF00779 BTK motif 0.0023 PF01180 Dihydroorotate dehydrogenase 0.0021 PF02984 Cyclin, C-terminal domain 0.0021 PF00134 Cyclin, N-terminal domain 0.0021 PF12126 Protein of unknown function (DUF3583), 0.0021 PF07970 Endoplasmic reticulum vesicle transporter 0.0021 PF00994 Probable molybdopterin binding domain 0.0021 PF03454 MoeA C-terminal region (domain IV), 0.0021 PF03453 MoeA N-terminal region (domain I and II), 0.0021 PF02828 L27 domain 0.0021 PF00431 CUB domain 0.0021 PF00514 Armadillo/beta-catenin-like repeat 0.0021 PF01094 Receptor family ligand binding region 0.0018 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0016 PF08399 VWA N-terminal 0.0016 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0016 PF00089 Trypsin 0.0016 PF02743 Cache domain 0.0014 PF00310 Glutamine amidotransferases class-II 0.0014 PF00989 PAS fold 0.0013 PF00303 Thymidylate synthase 0.0013 PF01369 Sec7 domain 0.0013 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0012 PF05193 Peptidase M16 inactive domain 0.0012 PF00675 Insulinase (Peptidase family M16), 0.0011 PF00406 Adenylate kinase 0.0010 PF00462 Glutaredoxin 0.0010 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0009 PF00041 Fibronectin type III domain 0.0009 PF00042 Globin 0.0009 PF08763 Voltage gated calcium channel IQ domain 0.0008 PF07653 Variant SH3 domain 0.0006 PF01733 Nucleoside transporter 0.0006 PF02189 Immunoreceptor tyrosine-based activation motif 0.0006 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0006 PF00027 Cyclic nucleotide-binding domain 0.0005 PF06617 M-phase inducer phosphatase 0.0005 PF03957 Jun-like transcription factor 0.0005 PF00581 Rhodanese-like domain 0.0003 PF02008 CXXC zinc finger domain 0.0003 PF02525 Flavodoxin-like fold 0.0003 PF01426 BAH domain 0.0003 PF06464 DMAP1-binding Domain 0.0002 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.0002 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0001 PF02867 Ribonucleotide reductase, barrel domain 0.0001 PF02460 Patched family 0.0001 PF00595 PDZ domain (Also known as DHR or GLGF), 0.0001 PF00317 Ribonucleotide reductase, all-alpha domain 0.0001 PF03477 ATP cone domain SUB730 Nc1ccc(Cl)cc1 0.3413 PF03073 TspO/MBR family 0.3085 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.3085 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0340 PF00343 Carbohydrate phosphorylase 0.0310 PF08403 Amino acid permease N-terminal 0.0295 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0278 PF02254 TrkA-N domain 0.0278 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0274 PF00989 PAS fold 0.0227 PF02196 Raf-like Ras-binding domain 0.0223 PF00194 Eukaryotic-type carbonic anhydrase 0.0215 PF00027 Cyclic nucleotide-binding domain 0.0207 PF00209 Sodium:neurotransmitter symporter family 0.0192 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0190 PF00001 7 transmembrane receptor (rhodopsin family), 0.0188 PF00018 SH3 domain 0.0186 PF00186 Dihydrofolate reductase 0.0173 PF00520 Ion transport protein 0.0164 PF00017 SH2 domain 0.0152 PF01007 Inward rectifier potassium channel 0.0151 PF06512 Sodium ion transport-associated 0.0133 PF08919 F-actin binding 0.0108 PF00612 IQ calmodulin-binding motif 0.0108 PF00243 Nerve growth factor family 0.0103 PF00664 ABC transporter transmembrane region 0.0099 PF00689 Cation transporting ATPase, C-terminus 0.0099 PF00690 Cation transporter/ATPase, N-terminus 0.0097 PF01404 Ephrin receptor ligand binding domain 0.0097 PF00536 SAM domain (Sterile alpha motif), 0.0094 PF00005 ABC transporter 0.0090 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0083 PF00122 E1-E2 ATPase 0.0073 PF00324 Amino acid permease 0.0065 PF01017 STAT protein, all-alpha domain 0.0065 PF02865 STAT protein, protein interaction domain 0.0065 PF02864 STAT protein, DNA binding domain 0.0058 PF01234 NNMT/PNMT/TEMT family 0.0057 PF00702 haloacid dehalogenase-like hydrolase 0.0054 PF00069 Protein kinase domain 0.0051 PF00191 Annexin 0.0027 PF08399 VWA N-terminal 0.0027 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0027 PF02743 Cache domain 0.0026 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0018 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0017 PF03530 Calcium-activated SK potassium channel 0.0017 PF02888 Calmodulin binding domain 0.0016 PF07686 Immunoglobulin V-set domain 0.0015 PF02038 ATP1G1/PLM/MAT8 family 0.0015 PF03630 Fumble 0.0015 PF02060 Slow voltage-gated potassium channel 0.0015 PF01734 Patatin-like phospholipase 0.0015 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0015 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0008 PF03520 KCNQ voltage-gated potassium channel 0.0007 PF00146 NADH dehydrogenase 0.0006 PF00858 Amiloride-sensitive sodium channel 0.0002 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0002 PF00757 Furin-like cysteine rich region 0.0002 PF08377 MAP2/Tau projection domain 0.0002 PF00631 GGL domain 0.0002 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0002 PF01030 Receptor L domain 0.0001 PF11956 Ankyrin-G binding motif of KCNQ2-3 0.0001 PF01833 IPT/TIG domain 0.0001 PF01403 Sema domain 0.0001 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0001 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 0.0001 PF02185 Hr1 repeat 0.0001 PF00717 Peptidase S24-like 0.0001 PF08912 Rho Binding 0.0001 PF01437 Plexin repeat 0.0001 PF02758 PAAD/DAPIN/Pyrin domain SUB793 NC1CCC(Cl)CC1 0.3413 PF03073 TspO/MBR family 0.3085 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.3085 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0340 PF00343 Carbohydrate phosphorylase 0.0310 PF08403 Amino acid permease N-terminal 0.0295 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0278 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0278 PF02254 TrkA-N domain 0.0274 PF00989 PAS fold 0.0227 PF02196 Raf-like Ras-binding domain 0.0223 PF00194 Eukaryotic-type carbonic anhydrase 0.0215 PF00027 Cyclic nucleotide-binding domain 0.0207 PF00209 Sodium:neurotransmitter symporter family 0.0192 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0190 PF00001 7 transmembrane receptor (rhodopsin family), 0.0188 PF00018 SH3 domain 0.0186 PF00186 Dihydrofolate reductase 0.0173 PF00520 Ion transport protein 0.0164 PF00017 SH2 domain 0.0152 PF01007 Inward rectifier potassium channel 0.0151 PF06512 Sodium ion transport-associated 0.0133 PF08919 F-actin binding 0.0108 PF00612 IQ calmodulin-binding motif 0.0108 PF00243 Nerve growth factor family 0.0103 PF00664 ABC transporter transmembrane region 0.0099 PF00689 Cation transporting ATPase, C-terminus 0.0099 PF00690 Cation transporter/ATPase, N-terminus 0.0097 PF01404 Ephrin receptor ligand binding domain 0.0097 PF00536 SAM domain (Sterile alpha motif), 0.0094 PF00005 ABC transporter 0.0090 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0083 PF00122 E1-E2 ATPase 0.0073 PF00324 Amino acid permease 0.0065 PF01017 STAT protein, all-alpha domain 0.0065 PF02864 STAT protein, DNA binding domain 0.0065 PF02865 STAT protein, protein interaction domain 0.0058 PF01234 NNMT/PNMT/TEMT family 0.0057 PF00702 haloacid dehalogenase-like hydrolase 0.0054 PF00069 Protein kinase domain 0.0051 PF00191 Annexin 0.0027 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0027 PF08399 VWA N-terminal 0.0027 PF02743 Cache domain 0.0026 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0018 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0017 PF03530 Calcium-activated SK potassium channel 0.0017 PF02888 Calmodulin binding domain 0.0016 PF07686 Immunoglobulin V-set domain 0.0015 PF03630 Fumble 0.0015 PF02060 Slow voltage-gated potassium channel 0.0015 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0015 PF01734 Patatin-like phospholipase 0.0015 PF02038 ATP1G1/PLM/MAT8 family 0.0015 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0008 PF03520 KCNQ voltage-gated potassium channel 0.0007 PF00146 NADH dehydrogenase 0.0006 PF00858 Amiloride-sensitive sodium channel 0.0002 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0002 PF00631 GGL domain 0.0002 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0002 PF00757 Furin-like cysteine rich region 0.0002 PF01030 Receptor L domain 0.0002 PF08377 MAP2/Tau projection domain 0.0001 PF00717 Peptidase S24-like 0.0001 PF11956 Ankyrin-G binding motif of KCNQ2-3 0.0001 PF01437 Plexin repeat 0.0001 PF01403 Sema domain 0.0001 PF01833 IPT/TIG domain 0.0001 PF02185 Hr1 repeat 0.0001 PF02758 PAAD/DAPIN/Pyrin domain 0.0001 PF08912 Rho Binding 0.0001 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0001 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region SUB461 C-C-C#C 0.3384 PF02159 Oestrogen receptor 0.2507 PF02161 Progesterone receptor 0.2006 PF00105 Zinc finger, C4 type (two domains), 0.1979 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0605 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0605 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0550 PF01593 Flavin containing amine oxidoreductase 0.0549 PF02155 Glucocorticoid receptor 0.0348 PF00191 Annexin 0.0323 PF00273 Serum albumin family 0.0226 PF00039 Fibronectin type I domain 0.0218 PF03098 Animal haem peroxidase 0.0215 PF02166 Androgen receptor 0.0187 PF08491 Squalene epoxidase 0.0186 PF00079 Serpin (serine protease inhibitor), 0.0172 PF00576 HIUase/Transthyretin family 0.0162 PF01735 Lysophospholipase catalytic domain 0.0160 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0160 PF02180 Bcl-2 homology region 4 0.0156 PF11825 Protein of unknown function (DUF3345), 0.0147 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0135 PF00146 NADH dehydrogenase 0.0131 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0127 PF01030 Receptor L domain 0.0127 PF00757 Furin-like cysteine rich region 0.0111 PF07884 Vitamin K epoxide reductase family 0.0110 PF00167 Fibroblast growth factor 0.0099 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0096 PF03171 2OG-Fe(II), oxygenase superfamily 0.0082 PF08718 Glycolipid transfer protein (GLTP), 0.0075 PF00690 Cation transporter/ATPase, N-terminus 0.0075 PF00689 Cation transporting ATPase, C-terminus 0.0072 PF02214 K+ channel tetramerisation domain 0.0072 PF00405 Transferrin 0.0068 PF03765 CRAL/TRIO, N-terminus 0.0068 PF00650 CRAL/TRIO domain 0.0066 PF00342 Phosphoglucose isomerase 0.0066 PF02065 Melibiase 0.0066 PF07648 Kazal-type serine protease inhibitor domain 0.0066 PF00143 Interferon alpha/beta domain 0.0061 PF00224 Pyruvate kinase, barrel domain 0.0061 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0061 PF02887 Pyruvate kinase, alpha/beta domain 0.0060 PF00122 E1-E2 ATPase 0.0058 PF00168 C2 domain 0.0057 PF03414 Glycosyltransferase family 6 0.0053 PF00432 Prenyltransferase and squalene oxidase repeat 0.0052 PF07654 Immunoglobulin C1-set domain 0.0047 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0047 PF00459 Inositol monophosphatase family 0.0047 PF08702 Fibrinogen alpha/beta chain family 0.0042 PF03160 Calx-beta domain 0.0042 PF00487 Fatty acid desaturase 0.0040 PF12160 Fibrinogen alpha C domain 0.0040 PF00884 Sulfatase 0.0040 PF09164 Vitamin D binding protein, domain III 0.0040 PF01699 Sodium/calcium exchanger protein 0.0040 PF01187 Macrophage migration inhibitory factor (MIF), 0.0040 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0040 PF00293 NUDIX domain 0.0040 PF03781 Formylglycine-generating sulfatase enzyme 0.0038 PF00549 CoA-ligase 0.0038 PF00248 Aldo/keto reductase family 0.0036 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0035 PF00390 Malic enzyme, N-terminal domain 0.0035 PF03949 Malic enzyme, NAD binding domain 0.0034 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0033 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0033 PF00702 haloacid dehalogenase-like hydrolase 0.0032 PF07690 Major Facilitator Superfamily 0.0031 PF00939 Sodium:sulfate symporter transmembrane region 0.0031 PF00821 Phosphoenolpyruvate carboxykinase 0.0031 PF08442 ATP-grasp domain 0.0030 PF08534 Redoxin 0.0030 PF00489 Interleukin-6/G-CSF/MGF family 0.0030 PF00041 Fibronectin type III domain 0.0028 PF00581 Rhodanese-like domain 0.0028 PF06617 M-phase inducer phosphatase 0.0026 PF00194 Eukaryotic-type carbonic anhydrase 0.0025 PF00084 Sushi domain (SCR repeat), 0.0025 PF03727 Hexokinase 0.0025 PF00349 Hexokinase 0.0024 PF07686 Immunoglobulin V-set domain 0.0023 PF00149 Calcineurin-like phosphoesterase 0.0023 PF00688 TGF-beta propeptide 0.0023 PF00019 Transforming growth factor beta like domain 0.0023 PF00890 FAD binding domain 0.0023 PF00089 Trypsin 0.0023 PF01144 Coenzyme A transferase 0.0022 PF02525 Flavodoxin-like fold 0.0021 PF00337 Galactoside-binding lectin 0.0017 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 0.0017 PF00106 short chain dehydrogenase 0.0016 PF00328 Histidine acid phosphatase 0.0016 PF01532 Glycosyl hydrolase family 47 0.0016 PF03770 Inositol polyphosphate kinase 0.0015 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0015 PF00682 HMGL-like 0.0015 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0015 PF01391 Collagen triple helix repeat (20 copies), 0.0013 PF02145 Rap/ran-GAP 0.0013 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0013 PF12026 Domain of unknown function (DUF3513), 0.0013 PF02928 C5HC2 zinc finger 0.0013 PF08917 Transforming growth factor beta receptor 2 ectodomain 0.0013 PF00631 GGL domain 0.0013 PF02984 Cyclin, C-terminal domain 0.0013 PF05328 CybS 0.0013 PF01042 Endoribonuclease L-PSP 0.0013 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0013 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0013 PF04055 Radical SAM superfamily 0.0013 PF01161 Phosphatidylethanolamine-binding protein 0.0013 PF07732 Multicopper oxidase 0.0013 PF00031 Cystatin domain 0.0013 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0013 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0013 PF00514 Armadillo/beta-catenin-like repeat 0.0013 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0013 PF01753 MYND finger 0.0013 PF00246 Zinc carboxypeptidase 0.0013 PF02188 GoLoco motif 0.0013 PF02828 L27 domain 0.0013 PF08516 ADAM cysteine-rich 0.0013 PF02629 CoA binding domain 0.0013 PF00403 Heavy-metal-associated domain 0.0013 PF07970 Endoplasmic reticulum vesicle transporter 0.0013 PF08833 Axin beta-catenin binding domain 0.0013 PF00778 DIX domain 0.0013 PF12126 Protein of unknown function (DUF3583), 0.0013 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0013 PF04051 Transport protein particle (TRAPP), component 0.0013 PF04711 Apolipoprotein A-II (ApoA-II), 0.0013 PF00134 Cyclin, N-terminal domain 0.0013 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0013 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0013 PF03453 MoeA N-terminal region (domain I and II), 0.0013 PF01118 Semialdehyde dehydrogenase, NAD binding domain 0.0013 PF00236 Glycoprotein hormone 0.0013 PF03454 MoeA C-terminal region (domain IV), 0.0013 PF06907 Latexin 0.0013 PF02121 Phosphatidylinositol transfer protein 0.0013 PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit 0.0013 PF08429 PLU-1-like protein 0.0013 PF00090 Thrombospondin type 1 domain 0.0013 PF00093 von Willebrand factor type C domain 0.0013 PF00762 Ferrochelatase 0.0013 PF08824 Serine rich protein interaction domain 0.0013 PF02970 Tubulin binding cofactor A 0.0013 PF01151 GNS1/SUR4 family 0.0013 PF00270 DEAD/DEAH box helicase 0.0013 PF01363 FYVE zinc finger 0.0013 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0013 PF00994 Probable molybdopterin binding domain 0.0013 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0013 PF01388 ARID/BRIGHT DNA binding domain 0.0013 PF02910 domain 0.0013 PF00806 Pumilio-family RNA binding repeat 0.0013 PF02210 Laminin G domain 0.0013 PF00628 PHD-finger 0.0013 PF04756 OST3 / OST6 family 0.0013 PF00274 Fructose-bisphosphate aldolase class-I 0.0013 PF03572 Peptidase family S41 0.0013 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0013 PF05735 Thrombospondin C-terminal region 0.0013 PF02373 JmjC domain 0.0013 PF00021 u-PAR/Ly-6 domain 0.0013 PF02375 jmjN domain 0.0013 PF00703 domain 0.0013 PF01562 Reprolysin family propeptide 0.0013 PF00200 Disintegrin 0.0013 PF08321 PPP5 0.0013 PF00969 Class II histocompatibility antigen, beta domain 0.0013 PF00860 Permease family 0.0013 PF05586 Anthrax receptor C-terminus region 0.0013 PF05587 Anthrax receptor extracellular domain 0.0012 PF00071 Ras family 0.0011 PF01477 PLAT/LH2 domain 0.0010 PF00305 Lipoxygenase 0.0009 PF00433 Protein kinase C terminal domain 0.0006 PF07645 Calcium-binding EGF domain 0.0006 PF00059 Lectin C-type domain 0.0005 PF00067 Cytochrome P450 0.0005 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0005 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0004 PF00560 Leucine Rich Repeat 0.0003 PF01425 Amidase 0.0003 PF10420 Cytokine interleukin-12p40 C-terminus 0.0003 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0002 PF00431 CUB domain 0.0002 PF01227 GTP cyclohydrolase I 0.0001 PF02436 Conserved carboxylase domain 0.0001 PF02055 O-Glycosyl hydrolase family 30 0.0001 PF02780 Transketolase, C-terminal domain 0.0001 PF03351 DOMON domain 0.0001 PF03062 MBOAT family 0.0001 PF05118 Aspartyl/Asparaginyl beta-hydroxylase 0.0001 PF00212 Atrial natriuretic peptide 0.0001 PF00714 Interferon gamma 0.0001 PF00574 Clp protease 0.0001 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0001 PF00265 Thymidine kinase 0.0001 PF00169 PH domain 0.0001 PF01369 Sec7 domain SUB384 C(~S)(:C) 0.3368 PF00194 Eukaryotic-type carbonic anhydrase 0.0802 PF08403 Amino acid permease N-terminal 0.0484 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0484 PF02254 TrkA-N domain 0.0411 PF01471 Putative peptidoglycan binding domain 0.0411 PF00045 Hemopexin 0.0393 PF00091 Tubulin/FtsZ family, GTPase domain 0.0393 PF01007 Inward rectifier potassium channel 0.0393 PF03953 Tubulin C-terminal domain 0.0378 PF00413 Matrixin 0.0377 PF00324 Amino acid permease 0.0287 PF00001 7 transmembrane receptor (rhodopsin family), 0.0275 PF00102 Protein-tyrosine phosphatase 0.0269 PF02798 Glutathione S-transferase, N-terminal domain 0.0267 PF00043 Glutathione S-transferase, C-terminal domain 0.0233 PF00689 Cation transporting ATPase, C-terminus 0.0233 PF00690 Cation transporter/ATPase, N-terminus 0.0199 PF00122 E1-E2 ATPase 0.0197 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0176 PF01590 GAF domain 0.0165 PF00664 ABC transporter transmembrane region 0.0152 PF00702 haloacid dehalogenase-like hydrolase 0.0144 PF00005 ABC transporter 0.0135 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0135 PF09396 Thrombin light chain 0.0114 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0109 PF08983 Domain of unknown function (DUF1856), 0.0108 PF03098 Animal haem peroxidase 0.0102 PF00156 Phosphoribosyl transferase domain 0.0093 PF00478 IMP dehydrogenase / GMP reductase domain 0.0093 PF00854 POT family 0.0093 PF00255 Glutathione peroxidase 0.0084 PF00962 Adenosine/AMP deaminase 0.0084 PF01770 Reduced folate carrier 0.0076 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0076 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0071 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0071 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0071 PF02772 S-adenosylmethionine synthetase, central domain 0.0070 PF00167 Fibroblast growth factor 0.0066 PF10397 Adenylosuccinate lyase C-terminus 0.0062 PF01068 ATP dependent DNA ligase domain 0.0062 PF04679 ATP dependent DNA ligase C terminal region 0.0062 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0061 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0057 PF08912 Rho Binding 0.0057 PF02803 Thiolase, C-terminal domain 0.0057 PF00108 Thiolase, N-terminal domain 0.0057 PF02185 Hr1 repeat 0.0056 PF08441 Integrin alpha 0.0054 PF12497 Estrogen receptor beta 0.0051 PF08725 Integrin beta cytoplasmic domain 0.0049 PF02060 Slow voltage-gated potassium channel 0.0047 PF11857 Domain of unknown function (DUF3377), 0.0046 PF02785 Biotin carboxylase C-terminal domain 0.0045 PF00656 Caspase domain 0.0044 PF01124 MAPEG family 0.0044 PF01323 DSBA-like thioredoxin domain 0.0040 PF02038 ATP1G1/PLM/MAT8 family 0.0038 PF00245 Alkaline phosphatase 0.0038 PF04321 RmlD substrate binding domain 0.0036 PF01039 Carboxyl transferase domain 0.0036 PF02793 Hormone receptor domain 0.0036 PF00002 7 transmembrane receptor (Secretin family), 0.0035 PF00958 GMP synthase C terminal domain 0.0034 PF00364 Biotin-requiring enzyme 0.0033 PF07965 Integrin beta tail domain 0.0033 PF00362 Integrin, beta chain 0.0031 PF00357 Integrin alpha cytoplasmic region 0.0030 PF02146 Sir2 family 0.0030 PF01431 Peptidase family M13 0.0030 PF05649 Peptidase family M13 0.0030 PF00112 Papain family cysteine protease 0.0029 PF06617 M-phase inducer phosphatase 0.0029 PF00581 Rhodanese-like domain 0.0029 PF00089 Trypsin 0.0029 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0028 PF00027 Cyclic nucleotide-binding domain 0.0028 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0028 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0027 PF00520 Ion transport protein 0.0027 PF00206 Lyase 0.0027 PF02574 Homocysteine S-methyltransferase 0.0026 PF00989 PAS fold 0.0025 PF00273 Serum albumin family 0.0023 PF00230 Major intrinsic protein 0.0021 PF03099 Biotin/lipoate A/B protein ligase family 0.0021 PF01234 NNMT/PNMT/TEMT family 0.0021 PF01916 Deoxyhypusine synthase 0.0021 PF00051 Kringle domain 0.0020 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0019 PF08326 Acetyl-CoA carboxylase, central region 0.0019 PF01406 tRNA synthetases class I (C), catalytic domain 0.0019 PF01641 SelR domain 0.0019 PF09334 tRNA synthetases class I (M), 0.0017 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0016 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0014 PF01530 Zinc finger, C2HC type 0.0014 PF02820 mbt repeat 0.0014 PF07885 Ion channel 0.0014 PF00188 Cysteine-rich secretory protein family 0.0013 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0012 PF00489 Interleukin-6/G-CSF/MGF family 0.0012 PF10420 Cytokine interleukin-12p40 C-terminus 0.0011 PF08447 PAS fold 0.0011 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0011 PF08466 Inward rectifier potassium channel N-terminal 0.0011 PF00578 AhpC/TSA family 0.0010 PF00040 Fibronectin type II domain 0.0010 PF07966 A1 Propeptide 0.0009 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0009 PF03489 Saposin-like type B, region 2 0.0009 PF08702 Fibrinogen alpha/beta chain family 0.0009 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0009 PF03520 KCNQ voltage-gated potassium channel 0.0009 PF00474 Sodium:solute symporter family 0.0008 PF03199 Eukaryotic glutathione synthase 0.0008 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0007 PF00287 Sodium / potassium ATPase beta chain 0.0007 PF01030 Receptor L domain 0.0007 PF00757 Furin-like cysteine rich region 0.0007 PF00092 von Willebrand factor type A domain 0.0007 PF05995 Cysteine dioxygenase type I 0.0006 PF00822 PMP-22/EMP/MP20/Claudin family 0.0006 PF08919 F-actin binding 0.0006 PF00625 Guanylate kinase 0.0006 PF00026 Eukaryotic aspartyl protease 0.0005 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0005 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0005 PF02743 Cache domain 0.0005 PF00341 Platelet-derived growth factor (PDGF), 0.0005 PF08399 VWA N-terminal 0.0004 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0004 PF09193 Cholecystokinin A receptor, N-terminal 0.0004 PF00337 Galactoside-binding lectin 0.0004 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0004 PF08833 Axin beta-catenin binding domain 0.0004 PF04055 Radical SAM superfamily 0.0004 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0004 PF00778 DIX domain 0.0003 PF00431 CUB domain 0.0003 PF07645 Calcium-binding EGF domain 0.0003 PF00183 Hsp90 protein 0.0003 PF00850 Histone deacetylase domain 0.0003 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF00084 Sushi domain (SCR repeat), 0.0003 PF00024 PAN domain 0.0003 PF00020 TNFR/NGFR cysteine-rich region 0.0003 PF01731 Arylesterase 0.0003 PF12160 Fibrinogen alpha C domain 0.0003 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0002 PF00058 Low-density lipoprotein receptor repeat class B 0.0002 PF00059 Lectin C-type domain 0.0002 PF00462 Glutaredoxin 0.0001 PF02189 Immunoreceptor tyrosine-based activation motif 0.0001 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0001 PF01019 Gamma-glutamyltranspeptidase 0.0001 PF00433 Protein kinase C terminal domain 0.0001 PF00439 Bromodomain 0.0001 PF00856 SET domain 0.0001 PF02493 MORN repeat 0.0001 PF02237 Biotin protein ligase C terminal domain 0.0001 PF00756 Putative esterase 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF00806 Pumilio-family RNA binding repeat 0.0001 PF01244 Membrane dipeptidase (Peptidase family M19), 0.0001 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF01835 MG2 domain 0.0001 PF01733 Nucleoside transporter 0.0001 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0001 PF01625 Peptide methionine sulfoxide reductase SUB324 P-H 0.3332 PF00273 Serum albumin family 0.2578 PF12179 I-kappa-kinase-beta NEMO binding domain 0.2423 PF08534 Redoxin 0.1259 PF00854 POT family 0.0700 PF09396 Thrombin light chain 0.0590 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0590 PF02180 Bcl-2 homology region 4 0.0446 PF02460 Patched family 0.0441 PF03062 MBOAT family 0.0439 PF01731 Arylesterase 0.0420 PF00151 Lipase 0.0348 PF00069 Protein kinase domain 0.0299 PF05649 Peptidase family M13 0.0299 PF01431 Peptidase family M13 0.0298 PF01401 Angiotensin-converting enzyme 0.0294 PF00975 Thioesterase domain 0.0294 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0294 PF08659 KR domain 0.0294 PF00698 Acyl transferase domain 0.0294 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0254 PF01477 PLAT/LH2 domain 0.0242 PF01433 Peptidase family M1 0.0215 PF00051 Kringle domain 0.0209 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0170 PF00576 HIUase/Transthyretin family 0.0163 PF00550 Phosphopantetheine attachment site 0.0163 PF00343 Carbohydrate phosphorylase 0.0140 PF00134 Cyclin, N-terminal domain 0.0140 PF02984 Cyclin, C-terminal domain 0.0140 PF07970 Endoplasmic reticulum vesicle transporter 0.0140 PF12126 Protein of unknown function (DUF3583), 0.0138 PF00059 Lectin C-type domain 0.0128 PF00091 Tubulin/FtsZ family, GTPase domain 0.0128 PF03953 Tubulin C-terminal domain 0.0128 PF03957 Jun-like transcription factor 0.0127 PF00489 Interleukin-6/G-CSF/MGF family 0.0114 PF07645 Calcium-binding EGF domain 0.0114 PF02423 Ornithine cyclodeaminase/mu-crystallin family 0.0105 PF00664 ABC transporter transmembrane region 0.0079 PF00170 bZIP transcription factor 0.0079 PF00005 ABC transporter 0.0073 PF00107 Zinc-binding dehydrogenase 0.0070 PF00643 B-box zinc finger 0.0052 PF00089 Trypsin 0.0036 PF00433 Protein kinase C terminal domain 0.0015 PF00169 PH domain 0.0008 PF00328 Histidine acid phosphatase 0.0008 PF00462 Glutaredoxin 0.0006 PF03098 Animal haem peroxidase SUB95 >= 1 Au 0.3332 PF00273 Serum albumin family 0.2578 PF12179 I-kappa-kinase-beta NEMO binding domain 0.2423 PF08534 Redoxin 0.1259 PF00854 POT family 0.0700 PF09396 Thrombin light chain 0.0590 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0590 PF02180 Bcl-2 homology region 4 0.0446 PF02460 Patched family 0.0441 PF03062 MBOAT family 0.0439 PF01731 Arylesterase 0.0420 PF00151 Lipase 0.0348 PF00069 Protein kinase domain 0.0299 PF05649 Peptidase family M13 0.0299 PF01431 Peptidase family M13 0.0298 PF01401 Angiotensin-converting enzyme 0.0294 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0294 PF00975 Thioesterase domain 0.0294 PF08659 KR domain 0.0294 PF00698 Acyl transferase domain 0.0294 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0254 PF01477 PLAT/LH2 domain 0.0242 PF01433 Peptidase family M1 0.0215 PF00051 Kringle domain 0.0209 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0170 PF00576 HIUase/Transthyretin family 0.0163 PF00343 Carbohydrate phosphorylase 0.0163 PF00550 Phosphopantetheine attachment site 0.0140 PF07970 Endoplasmic reticulum vesicle transporter 0.0140 PF02984 Cyclin, C-terminal domain 0.0140 PF12126 Protein of unknown function (DUF3583), 0.0140 PF00134 Cyclin, N-terminal domain 0.0138 PF00059 Lectin C-type domain 0.0128 PF03953 Tubulin C-terminal domain 0.0128 PF03957 Jun-like transcription factor 0.0128 PF00091 Tubulin/FtsZ family, GTPase domain 0.0127 PF00489 Interleukin-6/G-CSF/MGF family 0.0114 PF02423 Ornithine cyclodeaminase/mu-crystallin family 0.0114 PF07645 Calcium-binding EGF domain 0.0105 PF00664 ABC transporter transmembrane region 0.0079 PF00170 bZIP transcription factor 0.0079 PF00005 ABC transporter 0.0073 PF00107 Zinc-binding dehydrogenase 0.0070 PF00643 B-box zinc finger 0.0052 PF00089 Trypsin 0.0036 PF00433 Protein kinase C terminal domain 0.0015 PF00169 PH domain 0.0008 PF00462 Glutaredoxin 0.0008 PF00328 Histidine acid phosphatase 0.0006 PF03098 Animal haem peroxidase SUB600 [#1]-C-C=C-[#1] 0.3239 PF00001 7 transmembrane receptor (rhodopsin family), 0.1379 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.1335 PF03098 Animal haem peroxidase 0.1207 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1203 PF00105 Zinc finger, C4 type (two domains), 0.1138 PF02159 Oestrogen receptor 0.0833 PF00209 Sodium:neurotransmitter symporter family 0.0650 PF06512 Sodium ion transport-associated 0.0436 PF03073 TspO/MBR family 0.0365 PF09396 Thrombin light chain 0.0307 PF00005 ABC transporter 0.0301 PF00191 Annexin 0.0298 PF00989 PAS fold 0.0253 PF00067 Cytochrome P450 0.0250 PF00520 Ion transport protein 0.0248 PF00664 ABC transporter transmembrane region 0.0239 PF00027 Cyclic nucleotide-binding domain 0.0176 PF02155 Glucocorticoid receptor 0.0143 PF01593 Flavin containing amine oxidoreductase 0.0142 PF02161 Progesterone receptor 0.0102 PF00186 Dihydrofolate reductase 0.0096 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0073 PF01007 Inward rectifier potassium channel 0.0042 PF01735 Lysophospholipase catalytic domain 0.0038 PF11825 Protein of unknown function (DUF3345), 0.0032 PF00017 SH2 domain 0.0026 PF12497 Estrogen receptor beta SUB475 S:C:C:N 0.3160 PF00091 Tubulin/FtsZ family, GTPase domain 0.3160 PF03953 Tubulin C-terminal domain 0.0457 PF07884 Vitamin K epoxide reductase family 0.0420 PF00018 SH3 domain 0.0371 PF00017 SH2 domain 0.0366 PF01068 ATP dependent DNA ligase domain 0.0366 PF04679 ATP dependent DNA ligase C terminal region 0.0361 PF01770 Reduced folate carrier 0.0352 PF08919 F-actin binding 0.0318 PF00102 Protein-tyrosine phosphatase 0.0298 PF00194 Eukaryotic-type carbonic anhydrase 0.0256 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0250 PF01404 Ephrin receptor ligand binding domain 0.0250 PF00536 SAM domain (Sterile alpha motif), 0.0200 PF00854 POT family 0.0172 PF00478 IMP dehydrogenase / GMP reductase domain 0.0172 PF01017 STAT protein, all-alpha domain 0.0172 PF02864 STAT protein, DNA binding domain 0.0172 PF02865 STAT protein, protein interaction domain 0.0163 PF00656 Caspase domain 0.0163 PF00183 Hsp90 protein 0.0161 PF00377 Prion/Doppel alpha-helical domain 0.0161 PF02059 Interleukin-3 0.0159 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0155 PF02394 Interleukin-1 propeptide 0.0155 PF00340 Interleukin-1 / 18 0.0141 PF00962 Adenosine/AMP deaminase 0.0114 PF01023 S-100/ICaBP type calcium binding domain 0.0110 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0109 PF00156 Phosphoribosyl transferase domain 0.0104 PF00069 Protein kinase domain 0.0103 PF10397 Adenylosuccinate lyase C-terminus 0.0102 PF03098 Animal haem peroxidase 0.0102 PF00020 TNFR/NGFR cysteine-rich region 0.0091 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0090 PF00619 Caspase recruitment domain 0.0090 PF00958 GMP synthase C terminal domain 0.0086 PF02525 Flavodoxin-like fold 0.0086 PF00341 Platelet-derived growth factor (PDGF), 0.0077 PF00305 Lipoxygenase 0.0074 PF09396 Thrombin light chain 0.0072 PF00040 Fibronectin type II domain 0.0069 PF00041 Fibronectin type III domain 0.0069 PF12497 Estrogen receptor beta 0.0064 PF00531 Death domain 0.0064 PF00206 Lyase 0.0059 PF02155 Glucocorticoid receptor 0.0054 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0041 PF00001 7 transmembrane receptor (rhodopsin family), 0.0035 PF00273 Serum albumin family 0.0033 PF00709 Adenylosuccinate synthetase 0.0033 PF00117 Glutamine amidotransferase class-I 0.0032 PF01477 PLAT/LH2 domain 0.0027 PF00310 Glutamine amidotransferases class-II 0.0027 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0027 PF00245 Alkaline phosphatase 0.0026 PF00230 Major intrinsic protein 0.0025 PF00571 CBS domain 0.0022 PF01425 Amidase 0.0021 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0021 PF02254 TrkA-N domain 0.0019 PF00689 Cation transporting ATPase, C-terminus 0.0019 PF00690 Cation transporter/ATPase, N-terminus 0.0018 PF00287 Sodium / potassium ATPase beta chain 0.0016 PF01835 MG2 domain 0.0016 PF07678 A-macroglobulin complement component 0.0016 PF07677 A-macroglobulin receptor 0.0016 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0015 PF01731 Arylesterase 0.0012 PF00122 E1-E2 ATPase 0.0004 PF11857 Domain of unknown function (DUF3377), 0.0003 PF08403 Amino acid permease N-terminal 0.0002 PF00557 Metallopeptidase family M24 0.0002 PF00675 Insulinase (Peptidase family M16), 0.0002 PF02038 ATP1G1/PLM/MAT8 family 0.0002 PF05193 Peptidase M16 inactive domain SUB832 SC1C(Cl)CCCC1 0.3113 PF00194 Eukaryotic-type carbonic anhydrase 0.1321 PF08403 Amino acid permease N-terminal 0.1290 PF02254 TrkA-N domain 0.1290 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0606 PF00324 Amino acid permease 0.0334 PF00690 Cation transporter/ATPase, N-terminus 0.0334 PF00689 Cation transporting ATPase, C-terminus 0.0310 PF00520 Ion transport protein 0.0297 PF00122 E1-E2 ATPase 0.0266 PF00702 haloacid dehalogenase-like hydrolase 0.0236 PF02038 ATP1G1/PLM/MAT8 family 0.0132 PF02146 Sir2 family 0.0125 PF09396 Thrombin light chain 0.0095 PF02060 Slow voltage-gated potassium channel 0.0062 PF03520 KCNQ voltage-gated potassium channel 0.0061 PF00167 Fibroblast growth factor 0.0047 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0044 PF01007 Inward rectifier potassium channel 0.0031 PF00051 Kringle domain 0.0017 PF00045 Hemopexin 0.0017 PF01471 Putative peptidoglycan binding domain 0.0016 PF01916 Deoxyhypusine synthase 0.0014 PF00413 Matrixin 0.0012 PF00108 Thiolase, N-terminal domain 0.0012 PF02803 Thiolase, C-terminal domain 0.0009 PF02185 Hr1 repeat 0.0009 PF08912 Rho Binding 0.0009 PF01590 GAF domain 0.0005 PF10420 Cytokine interleukin-12p40 C-terminus 0.0002 PF08466 Inward rectifier potassium channel N-terminal 0.0002 PF00230 Major intrinsic protein 0.0002 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0002 PF08447 PAS fold 0.0001 PF03662 Glycosyl hydrolase family 79, N-terminal domain SUB769 Sc1c(Cl)cccc1 0.3113 PF00194 Eukaryotic-type carbonic anhydrase 0.1321 PF08403 Amino acid permease N-terminal 0.1290 PF02254 TrkA-N domain 0.1290 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0606 PF00324 Amino acid permease 0.0334 PF00690 Cation transporter/ATPase, N-terminus 0.0334 PF00689 Cation transporting ATPase, C-terminus 0.0310 PF00520 Ion transport protein 0.0297 PF00122 E1-E2 ATPase 0.0266 PF00702 haloacid dehalogenase-like hydrolase 0.0236 PF02038 ATP1G1/PLM/MAT8 family 0.0132 PF02146 Sir2 family 0.0125 PF09396 Thrombin light chain 0.0095 PF02060 Slow voltage-gated potassium channel 0.0062 PF03520 KCNQ voltage-gated potassium channel 0.0061 PF00167 Fibroblast growth factor 0.0047 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0044 PF01007 Inward rectifier potassium channel 0.0031 PF00051 Kringle domain 0.0017 PF01471 Putative peptidoglycan binding domain 0.0017 PF00045 Hemopexin 0.0016 PF01916 Deoxyhypusine synthase 0.0014 PF00413 Matrixin 0.0012 PF00108 Thiolase, N-terminal domain 0.0012 PF02803 Thiolase, C-terminal domain 0.0009 PF08912 Rho Binding 0.0009 PF01590 GAF domain 0.0009 PF02185 Hr1 repeat 0.0005 PF10420 Cytokine interleukin-12p40 C-terminus 0.0002 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0002 PF00230 Major intrinsic protein 0.0002 PF08466 Inward rectifier potassium channel N-terminal 0.0002 PF08447 PAS fold 0.0001 PF03662 Glycosyl hydrolase family 79, N-terminal domain SUB532 S-C:C-C 0.3088 PF00194 Eukaryotic-type carbonic anhydrase 0.0739 PF08403 Amino acid permease N-terminal 0.0448 PF02254 TrkA-N domain 0.0448 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0375 PF01471 Putative peptidoglycan binding domain 0.0375 PF00045 Hemopexin 0.0363 PF01007 Inward rectifier potassium channel 0.0348 PF00324 Amino acid permease 0.0345 PF00413 Matrixin 0.0343 PF00091 Tubulin/FtsZ family, GTPase domain 0.0343 PF03953 Tubulin C-terminal domain 0.0250 PF00001 7 transmembrane receptor (rhodopsin family), 0.0245 PF00102 Protein-tyrosine phosphatase 0.0234 PF02798 Glutathione S-transferase, N-terminal domain 0.0233 PF00043 Glutathione S-transferase, C-terminal domain 0.0216 PF00690 Cation transporter/ATPase, N-terminus 0.0216 PF00689 Cation transporting ATPase, C-terminus 0.0185 PF00122 E1-E2 ATPase 0.0180 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0162 PF01590 GAF domain 0.0154 PF00664 ABC transporter transmembrane region 0.0143 PF00702 haloacid dehalogenase-like hydrolase 0.0135 PF00005 ABC transporter 0.0129 PF09396 Thrombin light chain 0.0129 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0104 PF03098 Animal haem peroxidase 0.0099 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0095 PF08983 Domain of unknown function (DUF1856), 0.0089 PF00156 Phosphoribosyl transferase domain 0.0081 PF00854 POT family 0.0081 PF00255 Glutathione peroxidase 0.0081 PF00478 IMP dehydrogenase / GMP reductase domain 0.0074 PF01770 Reduced folate carrier 0.0073 PF00962 Adenosine/AMP deaminase 0.0068 PF00167 Fibroblast growth factor 0.0066 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0066 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0062 PF02772 S-adenosylmethionine synthetase, central domain 0.0062 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0062 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0058 PF10397 Adenylosuccinate lyase C-terminus 0.0058 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0054 PF01068 ATP dependent DNA ligase domain 0.0054 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0054 PF04679 ATP dependent DNA ligase C terminal region 0.0053 PF08912 Rho Binding 0.0053 PF02185 Hr1 repeat 0.0052 PF02803 Thiolase, C-terminal domain 0.0052 PF08441 Integrin alpha 0.0052 PF00108 Thiolase, N-terminal domain 0.0049 PF12497 Estrogen receptor beta 0.0048 PF08725 Integrin beta cytoplasmic domain 0.0046 PF02060 Slow voltage-gated potassium channel 0.0041 PF11857 Domain of unknown function (DUF3377), 0.0040 PF01323 DSBA-like thioredoxin domain 0.0040 PF02785 Biotin carboxylase C-terminal domain 0.0039 PF00656 Caspase domain 0.0038 PF02038 ATP1G1/PLM/MAT8 family 0.0038 PF01124 MAPEG family 0.0033 PF00245 Alkaline phosphatase 0.0033 PF04321 RmlD substrate binding domain 0.0032 PF00089 Trypsin 0.0032 PF00362 Integrin, beta chain 0.0032 PF07965 Integrin beta tail domain 0.0031 PF01039 Carboxyl transferase domain 0.0031 PF00027 Cyclic nucleotide-binding domain 0.0031 PF02793 Hormone receptor domain 0.0031 PF00958 GMP synthase C terminal domain 0.0031 PF00002 7 transmembrane receptor (Secretin family), 0.0030 PF00364 Biotin-requiring enzyme 0.0030 PF00112 Papain family cysteine protease 0.0030 PF00520 Ion transport protein 0.0030 PF02146 Sir2 family 0.0029 PF00357 Integrin alpha cytoplasmic region 0.0029 PF00989 PAS fold 0.0027 PF00581 Rhodanese-like domain 0.0027 PF06617 M-phase inducer phosphatase 0.0026 PF05649 Peptidase family M13 0.0026 PF01431 Peptidase family M13 0.0025 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0024 PF00206 Lyase 0.0024 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0024 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0023 PF00051 Kringle domain 0.0023 PF00230 Major intrinsic protein 0.0023 PF02574 Homocysteine S-methyltransferase 0.0022 PF01916 Deoxyhypusine synthase 0.0022 PF00273 Serum albumin family 0.0022 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0020 PF01234 NNMT/PNMT/TEMT family 0.0018 PF03099 Biotin/lipoate A/B protein ligase family 0.0018 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0016 PF01530 Zinc finger, C2HC type 0.0016 PF01406 tRNA synthetases class I (C), catalytic domain 0.0016 PF00188 Cysteine-rich secretory protein family 0.0016 PF01641 SelR domain 0.0016 PF02820 mbt repeat 0.0016 PF09334 tRNA synthetases class I (M), 0.0016 PF08326 Acetyl-CoA carboxylase, central region 0.0015 PF07885 Ion channel 0.0015 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0014 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0014 PF00489 Interleukin-6/G-CSF/MGF family 0.0013 PF08466 Inward rectifier potassium channel N-terminal 0.0012 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0012 PF00578 AhpC/TSA family 0.0012 PF08447 PAS fold 0.0011 PF07966 A1 Propeptide 0.0011 PF00040 Fibronectin type II domain 0.0010 PF03489 Saposin-like type B, region 2 0.0010 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0010 PF08702 Fibrinogen alpha/beta chain family 0.0010 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0010 PF03520 KCNQ voltage-gated potassium channel 0.0010 PF10420 Cytokine interleukin-12p40 C-terminus 0.0008 PF00287 Sodium / potassium ATPase beta chain 0.0008 PF00757 Furin-like cysteine rich region 0.0008 PF00474 Sodium:solute symporter family 0.0008 PF01030 Receptor L domain 0.0007 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0007 PF00822 PMP-22/EMP/MP20/Claudin family 0.0007 PF00092 von Willebrand factor type A domain 0.0007 PF00026 Eukaryotic aspartyl protease 0.0007 PF03199 Eukaryotic glutathione synthase 0.0006 PF00625 Guanylate kinase 0.0006 PF05995 Cysteine dioxygenase type I 0.0006 PF00341 Platelet-derived growth factor (PDGF), 0.0005 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0005 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0005 PF02743 Cache domain 0.0005 PF08919 F-actin binding 0.0005 PF08399 VWA N-terminal 0.0005 PF09193 Cholecystokinin A receptor, N-terminal 0.0004 PF00778 DIX domain 0.0004 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0004 PF04055 Radical SAM superfamily 0.0004 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0004 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0004 PF00337 Galactoside-binding lectin 0.0004 PF08833 Axin beta-catenin binding domain 0.0003 PF12160 Fibrinogen alpha C domain 0.0003 PF00084 Sushi domain (SCR repeat), 0.0003 PF00183 Hsp90 protein 0.0003 PF00020 TNFR/NGFR cysteine-rich region 0.0003 PF00024 PAN domain 0.0003 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0003 PF00850 Histone deacetylase domain 0.0003 PF00431 CUB domain 0.0003 PF01731 Arylesterase 0.0003 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF07645 Calcium-binding EGF domain 0.0002 PF00058 Low-density lipoprotein receptor repeat class B 0.0002 PF00059 Lectin C-type domain 0.0001 PF02189 Immunoreceptor tyrosine-based activation motif 0.0001 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0001 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF01244 Membrane dipeptidase (Peptidase family M19), 0.0001 PF01625 Peptide methionine sulfoxide reductase 0.0001 PF00856 SET domain 0.0001 PF00806 Pumilio-family RNA binding repeat 0.0001 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0001 PF00756 Putative esterase 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF02493 MORN repeat 0.0001 PF00433 Protein kinase C terminal domain 0.0001 PF00439 Bromodomain 0.0001 PF01835 MG2 domain 0.0001 PF01733 Nucleoside transporter 0.0001 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0001 PF01019 Gamma-glutamyltranspeptidase 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF00462 Glutaredoxin 0.0001 PF02237 Biotin protein ligase C terminal domain SUB811 SC1CC(Cl)CCC1 0.3038 PF00194 Eukaryotic-type carbonic anhydrase 0.1018 PF02254 TrkA-N domain 0.1018 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1016 PF08403 Amino acid permease N-terminal 0.0498 PF00324 Amino acid permease 0.0376 PF00689 Cation transporting ATPase, C-terminus 0.0376 PF00690 Cation transporter/ATPase, N-terminus 0.0335 PF00122 E1-E2 ATPase 0.0299 PF00702 haloacid dehalogenase-like hydrolase 0.0229 PF01007 Inward rectifier potassium channel 0.0185 PF00102 Protein-tyrosine phosphatase 0.0183 PF00520 Ion transport protein 0.0169 PF02146 Sir2 family 0.0145 PF10420 Cytokine interleukin-12p40 C-terminus 0.0134 PF01916 Deoxyhypusine synthase 0.0126 PF01471 Putative peptidoglycan binding domain 0.0126 PF00045 Hemopexin 0.0117 PF00413 Matrixin 0.0114 PF09396 Thrombin light chain 0.0099 PF02038 ATP1G1/PLM/MAT8 family 0.0098 PF02803 Thiolase, C-terminal domain 0.0098 PF00108 Thiolase, N-terminal domain 0.0097 PF00040 Fibronectin type II domain 0.0082 PF00043 Glutathione S-transferase, C-terminal domain 0.0078 PF02798 Glutathione S-transferase, N-terminal domain 0.0077 PF00069 Protein kinase domain 0.0074 PF08983 Domain of unknown function (DUF1856), 0.0053 PF00186 Dihydrofolate reductase 0.0052 PF00273 Serum albumin family 0.0042 PF00167 Fibroblast growth factor 0.0039 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0029 PF11857 Domain of unknown function (DUF3377), 0.0029 PF08702 Fibrinogen alpha/beta chain family 0.0029 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0028 PF00664 ABC transporter transmembrane region 0.0027 PF04679 ATP dependent DNA ligase C terminal region 0.0027 PF01068 ATP dependent DNA ligase domain 0.0024 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0020 PF03098 Animal haem peroxidase 0.0020 PF02793 Hormone receptor domain 0.0020 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0020 PF00002 7 transmembrane receptor (Secretin family), 0.0020 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0020 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0020 PF04055 Radical SAM superfamily 0.0020 PF00778 DIX domain 0.0020 PF08833 Axin beta-catenin binding domain 0.0019 PF00051 Kringle domain 0.0018 PF00005 ABC transporter 0.0017 PF00020 TNFR/NGFR cysteine-rich region 0.0016 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0014 PF01369 Sec7 domain 0.0014 PF00265 Thymidine kinase 0.0014 PF01731 Arylesterase 0.0013 PF00230 Major intrinsic protein 0.0013 PF08466 Inward rectifier potassium channel N-terminal 0.0012 PF12160 Fibrinogen alpha C domain 0.0010 PF00024 PAN domain 0.0010 PF03099 Biotin/lipoate A/B protein ligase family 0.0006 PF01462 Leucine rich repeat N-terminal domain 0.0006 PF00615 Regulator of G protein signaling domain 0.0006 PF00474 Sodium:solute symporter family 0.0004 PF00058 Low-density lipoprotein receptor repeat class B 0.0003 PF01234 NNMT/PNMT/TEMT family 0.0003 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0001 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0001 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF00531 Death domain SUB748 Sc1cc(Cl)ccc1 0.3038 PF00194 Eukaryotic-type carbonic anhydrase 0.1018 PF02254 TrkA-N domain 0.1018 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1016 PF08403 Amino acid permease N-terminal 0.0498 PF00324 Amino acid permease 0.0376 PF00690 Cation transporter/ATPase, N-terminus 0.0376 PF00689 Cation transporting ATPase, C-terminus 0.0335 PF00122 E1-E2 ATPase 0.0299 PF00702 haloacid dehalogenase-like hydrolase 0.0229 PF01007 Inward rectifier potassium channel 0.0185 PF00102 Protein-tyrosine phosphatase 0.0183 PF00520 Ion transport protein 0.0169 PF02146 Sir2 family 0.0145 PF10420 Cytokine interleukin-12p40 C-terminus 0.0134 PF01916 Deoxyhypusine synthase 0.0126 PF00045 Hemopexin 0.0126 PF01471 Putative peptidoglycan binding domain 0.0117 PF00413 Matrixin 0.0114 PF09396 Thrombin light chain 0.0099 PF02038 ATP1G1/PLM/MAT8 family 0.0098 PF02803 Thiolase, C-terminal domain 0.0098 PF00108 Thiolase, N-terminal domain 0.0097 PF00040 Fibronectin type II domain 0.0082 PF00043 Glutathione S-transferase, C-terminal domain 0.0078 PF02798 Glutathione S-transferase, N-terminal domain 0.0077 PF00069 Protein kinase domain 0.0074 PF08983 Domain of unknown function (DUF1856), 0.0053 PF00186 Dihydrofolate reductase 0.0052 PF00273 Serum albumin family 0.0042 PF00167 Fibroblast growth factor 0.0039 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0029 PF08702 Fibrinogen alpha/beta chain family 0.0029 PF11857 Domain of unknown function (DUF3377), 0.0029 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0028 PF00664 ABC transporter transmembrane region 0.0027 PF04679 ATP dependent DNA ligase C terminal region 0.0027 PF01068 ATP dependent DNA ligase domain 0.0024 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0020 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0020 PF04055 Radical SAM superfamily 0.0020 PF08833 Axin beta-catenin binding domain 0.0020 PF00002 7 transmembrane receptor (Secretin family), 0.0020 PF02793 Hormone receptor domain 0.0020 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0020 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0020 PF00778 DIX domain 0.0020 PF03098 Animal haem peroxidase 0.0019 PF00051 Kringle domain 0.0018 PF00005 ABC transporter 0.0017 PF00020 TNFR/NGFR cysteine-rich region 0.0016 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0014 PF00265 Thymidine kinase 0.0014 PF01369 Sec7 domain 0.0014 PF01731 Arylesterase 0.0013 PF08466 Inward rectifier potassium channel N-terminal 0.0013 PF00230 Major intrinsic protein 0.0012 PF12160 Fibrinogen alpha C domain 0.0010 PF00024 PAN domain 0.0010 PF03099 Biotin/lipoate A/B protein ligase family 0.0006 PF00474 Sodium:solute symporter family 0.0006 PF00615 Regulator of G protein signaling domain 0.0006 PF01462 Leucine rich repeat N-terminal domain 0.0004 PF00058 Low-density lipoprotein receptor repeat class B 0.0003 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0003 PF01234 NNMT/PNMT/TEMT family 0.0001 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF00531 Death domain 0.0001 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region SUB429 C(#C)(-H) 0.3032 PF02159 Oestrogen receptor 0.2247 PF02161 Progesterone receptor 0.1797 PF00105 Zinc finger, C4 type (two domains), 0.1773 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0542 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0542 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0493 PF01593 Flavin containing amine oxidoreductase 0.0492 PF02155 Glucocorticoid receptor 0.0312 PF00191 Annexin 0.0290 PF00273 Serum albumin family 0.0202 PF00039 Fibronectin type I domain 0.0196 PF03098 Animal haem peroxidase 0.0192 PF02166 Androgen receptor 0.0168 PF08491 Squalene epoxidase 0.0166 PF00079 Serpin (serine protease inhibitor), 0.0154 PF00576 HIUase/Transthyretin family 0.0145 PF01735 Lysophospholipase catalytic domain 0.0143 PF02180 Bcl-2 homology region 4 0.0143 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0140 PF11825 Protein of unknown function (DUF3345), 0.0132 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0121 PF00146 NADH dehydrogenase 0.0117 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0113 PF01030 Receptor L domain 0.0113 PF00757 Furin-like cysteine rich region 0.0100 PF07884 Vitamin K epoxide reductase family 0.0099 PF00167 Fibroblast growth factor 0.0089 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0086 PF03171 2OG-Fe(II), oxygenase superfamily 0.0073 PF08718 Glycolipid transfer protein (GLTP), 0.0067 PF00689 Cation transporting ATPase, C-terminus 0.0067 PF00690 Cation transporter/ATPase, N-terminus 0.0064 PF00405 Transferrin 0.0064 PF02214 K+ channel tetramerisation domain 0.0061 PF00650 CRAL/TRIO domain 0.0061 PF03765 CRAL/TRIO, N-terminus 0.0060 PF00342 Phosphoglucose isomerase 0.0060 PF02065 Melibiase 0.0060 PF00143 Interferon alpha/beta domain 0.0060 PF07648 Kazal-type serine protease inhibitor domain 0.0055 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0055 PF02887 Pyruvate kinase, alpha/beta domain 0.0055 PF00224 Pyruvate kinase, barrel domain 0.0053 PF00122 E1-E2 ATPase 0.0052 PF00168 C2 domain 0.0051 PF03414 Glycosyltransferase family 6 0.0047 PF00432 Prenyltransferase and squalene oxidase repeat 0.0046 PF07654 Immunoglobulin C1-set domain 0.0042 PF08702 Fibrinogen alpha/beta chain family 0.0042 PF00459 Inositol monophosphatase family 0.0042 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0038 PF03160 Calx-beta domain 0.0038 PF00487 Fatty acid desaturase 0.0035 PF01699 Sodium/calcium exchanger protein 0.0035 PF09164 Vitamin D binding protein, domain III 0.0035 PF00293 NUDIX domain 0.0035 PF00884 Sulfatase 0.0035 PF03781 Formylglycine-generating sulfatase enzyme 0.0035 PF01187 Macrophage migration inhibitory factor (MIF), 0.0035 PF12160 Fibrinogen alpha C domain 0.0035 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0034 PF00248 Aldo/keto reductase family 0.0034 PF00549 CoA-ligase 0.0032 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0031 PF00390 Malic enzyme, N-terminal domain 0.0031 PF03949 Malic enzyme, NAD binding domain 0.0030 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0030 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0030 PF00702 haloacid dehalogenase-like hydrolase 0.0029 PF07690 Major Facilitator Superfamily 0.0028 PF00939 Sodium:sulfate symporter transmembrane region 0.0028 PF08442 ATP-grasp domain 0.0028 PF00821 Phosphoenolpyruvate carboxykinase 0.0027 PF00041 Fibronectin type III domain 0.0027 PF00489 Interleukin-6/G-CSF/MGF family 0.0027 PF08534 Redoxin 0.0025 PF00581 Rhodanese-like domain 0.0025 PF06617 M-phase inducer phosphatase 0.0023 PF00084 Sushi domain (SCR repeat), 0.0023 PF00349 Hexokinase 0.0023 PF03727 Hexokinase 0.0023 PF00194 Eukaryotic-type carbonic anhydrase 0.0021 PF00890 FAD binding domain 0.0021 PF00688 TGF-beta propeptide 0.0021 PF07686 Immunoglobulin V-set domain 0.0021 PF00019 Transforming growth factor beta like domain 0.0021 PF01144 Coenzyme A transferase 0.0020 PF02525 Flavodoxin-like fold 0.0020 PF00149 Calcineurin-like phosphoesterase 0.0020 PF00089 Trypsin 0.0019 PF00337 Galactoside-binding lectin 0.0016 PF00106 short chain dehydrogenase 0.0015 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 0.0014 PF01532 Glycosyl hydrolase family 47 0.0014 PF00328 Histidine acid phosphatase 0.0014 PF03770 Inositol polyphosphate kinase 0.0013 PF00682 HMGL-like 0.0013 PF01391 Collagen triple helix repeat (20 copies), 0.0013 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0013 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0011 PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit 0.0011 PF00021 u-PAR/Ly-6 domain 0.0011 PF00762 Ferrochelatase 0.0011 PF04711 Apolipoprotein A-II (ApoA-II), 0.0011 PF05328 CybS 0.0011 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0011 PF00071 Ras family 0.0011 PF02928 C5HC2 zinc finger 0.0011 PF00969 Class II histocompatibility antigen, beta domain 0.0011 PF02121 Phosphatidylinositol transfer protein 0.0011 PF00274 Fructose-bisphosphate aldolase class-I 0.0011 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0011 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0011 PF00270 DEAD/DEAH box helicase 0.0011 PF01363 FYVE zinc finger 0.0011 PF08429 PLU-1-like protein 0.0011 PF01151 GNS1/SUR4 family 0.0011 PF00994 Probable molybdopterin binding domain 0.0011 PF02828 L27 domain 0.0011 PF02188 GoLoco motif 0.0011 PF02970 Tubulin binding cofactor A 0.0011 PF05586 Anthrax receptor C-terminus region 0.0011 PF05587 Anthrax receptor extracellular domain 0.0011 PF08824 Serine rich protein interaction domain 0.0011 PF00860 Permease family 0.0011 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0011 PF02910 domain 0.0011 PF06907 Latexin 0.0011 PF00403 Heavy-metal-associated domain 0.0011 PF07970 Endoplasmic reticulum vesicle transporter 0.0011 PF01562 Reprolysin family propeptide 0.0011 PF01161 Phosphatidylethanolamine-binding protein 0.0011 PF08321 PPP5 0.0011 PF01753 MYND finger 0.0011 PF00093 von Willebrand factor type C domain 0.0011 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0011 PF00090 Thrombospondin type 1 domain 0.0011 PF00246 Zinc carboxypeptidase 0.0011 PF00514 Armadillo/beta-catenin-like repeat 0.0011 PF00134 Cyclin, N-terminal domain 0.0011 PF00778 DIX domain 0.0011 PF00806 Pumilio-family RNA binding repeat 0.0011 PF01388 ARID/BRIGHT DNA binding domain 0.0011 PF12026 Domain of unknown function (DUF3513), 0.0011 PF00703 domain 0.0011 PF08516 ADAM cysteine-rich 0.0011 PF00236 Glycoprotein hormone 0.0011 PF07732 Multicopper oxidase 0.0011 PF01042 Endoribonuclease L-PSP 0.0011 PF02210 Laminin G domain 0.0011 PF08833 Axin beta-catenin binding domain 0.0011 PF01118 Semialdehyde dehydrogenase, NAD binding domain 0.0011 PF02145 Rap/ran-GAP 0.0011 PF00200 Disintegrin 0.0011 PF03572 Peptidase family S41 0.0011 PF04756 OST3 / OST6 family 0.0011 PF02629 CoA binding domain 0.0011 PF08917 Transforming growth factor beta receptor 2 ectodomain 0.0011 PF12126 Protein of unknown function (DUF3583), 0.0011 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0011 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0011 PF02984 Cyclin, C-terminal domain 0.0011 PF00628 PHD-finger 0.0011 PF00631 GGL domain 0.0011 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0011 PF03454 MoeA C-terminal region (domain IV), 0.0011 PF03453 MoeA N-terminal region (domain I and II), 0.0011 PF02373 JmjC domain 0.0011 PF02375 jmjN domain 0.0011 PF04051 Transport protein particle (TRAPP), component 0.0011 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0011 PF00031 Cystatin domain 0.0011 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0011 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0011 PF04055 Radical SAM superfamily 0.0011 PF05735 Thrombospondin C-terminal region 0.0011 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0010 PF01477 PLAT/LH2 domain 0.0009 PF00305 Lipoxygenase 0.0008 PF00433 Protein kinase C terminal domain 0.0005 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0005 PF00067 Cytochrome P450 0.0005 PF07645 Calcium-binding EGF domain 0.0005 PF00059 Lectin C-type domain 0.0004 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0003 PF01425 Amidase 0.0003 PF00560 Leucine Rich Repeat 0.0003 PF10420 Cytokine interleukin-12p40 C-terminus 0.0002 PF01227 GTP cyclohydrolase I 0.0002 PF00431 CUB domain 0.0002 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0001 PF02780 Transketolase, C-terminal domain 0.0001 PF00574 Clp protease 0.0001 PF02436 Conserved carboxylase domain 0.0001 PF00265 Thymidine kinase 0.0001 PF01369 Sec7 domain 0.0001 PF00212 Atrial natriuretic peptide 0.0001 PF05118 Aspartyl/Asparaginyl beta-hydroxylase 0.0001 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0001 PF03062 MBOAT family 0.0001 PF03351 DOMON domain 0.0001 PF02055 O-Glycosyl hydrolase family 30 0.0001 PF00714 Interferon gamma SUB288 C-F 0.3004 PF08070 DTHCT (NUC029), region 0.3004 PF00204 DNA gyrase B 0.3004 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1343 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1343 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1198 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0725 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0695 PF01735 Lysophospholipase catalytic domain 0.0685 PF00146 NADH dehydrogenase 0.0638 PF00191 Annexin 0.0629 PF00689 Cation transporting ATPase, C-terminus 0.0629 PF00690 Cation transporter/ATPase, N-terminus 0.0574 PF00194 Eukaryotic-type carbonic anhydrase 0.0569 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0556 PF00576 HIUase/Transthyretin family 0.0551 PF00122 E1-E2 ATPase 0.0548 PF00989 PAS fold 0.0494 PF02155 Glucocorticoid receptor 0.0478 PF00702 haloacid dehalogenase-like hydrolase 0.0456 PF00520 Ion transport protein 0.0453 PF00102 Protein-tyrosine phosphatase 0.0438 PF00027 Cyclic nucleotide-binding domain 0.0432 PF03073 TspO/MBR family 0.0404 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0403 PF02214 K+ channel tetramerisation domain 0.0382 PF02166 Androgen receptor 0.0370 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0360 PF00079 Serpin (serine protease inhibitor), 0.0340 PF00303 Thymidylate synthase 0.0329 PF00317 Ribonucleotide reductase, all-alpha domain 0.0329 PF03477 ATP cone domain 0.0329 PF02867 Ribonucleotide reductase, barrel domain 0.0273 PF01180 Dihydroorotate dehydrogenase 0.0253 PF00168 C2 domain 0.0250 PF02254 TrkA-N domain 0.0250 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0238 PF00757 Furin-like cysteine rich region 0.0238 PF01030 Receptor L domain 0.0213 PF03104 DNA polymerase family B, exonuclease domain 0.0213 PF00136 DNA polymerase family B 0.0213 PF08996 DNA Polymerase alpha zinc finger 0.0200 PF03098 Animal haem peroxidase 0.0194 PF00248 Aldo/keto reductase family 0.0189 PF00493 MCM2/3/5 family 0.0185 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0181 PF00631 GGL domain 0.0181 PF02888 Calmodulin binding domain 0.0181 PF03530 Calcium-activated SK potassium channel 0.0181 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0163 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0161 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0161 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0139 PF00028 Cadherin domain 0.0138 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0138 PF08063 PADR1 (NUC008), domain 0.0138 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0138 PF00533 BRCA1 C Terminus (BRCT), domain 0.0138 PF05406 WGR domain 0.0133 PF00069 Protein kinase domain 0.0131 PF02460 Patched family 0.0124 PF01007 Inward rectifier potassium channel 0.0120 PF03062 MBOAT family 0.0116 PF00654 Voltage gated chloride channel 0.0106 PF12491 Apolipoprotein B100 C terminal 0.0106 PF06448 Domain of Unknown Function (DUF1081), 0.0097 PF02196 Raf-like Ras-binding domain 0.0091 PF00489 Interleukin-6/G-CSF/MGF family 0.0091 PF08403 Amino acid permease N-terminal 0.0090 PF01731 Arylesterase 0.0085 PF00229 TNF(Tumour Necrosis Factor), family 0.0085 PF00273 Serum albumin family 0.0084 PF12497 Estrogen receptor beta 0.0080 PF07885 Ion channel 0.0071 PF00060 Ligand-gated ion channel 0.0071 PF02180 Bcl-2 homology region 4 0.0071 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0064 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0056 PF02159 Oestrogen receptor 0.0053 PF01347 Lipoprotein amino terminal region 0.0050 PF01094 Receptor family ligand binding region 0.0039 PF00554 Rel homology domain (RHD), 0.0036 PF08377 MAP2/Tau projection domain 0.0036 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0034 PF00058 Low-density lipoprotein receptor repeat class B 0.0033 PF06464 DMAP1-binding Domain 0.0033 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0033 PF01426 BAH domain 0.0033 PF02008 CXXC zinc finger domain 0.0031 PF00042 Globin 0.0030 PF00406 Adenylate kinase 0.0026 PF01017 STAT protein, all-alpha domain 0.0026 PF01391 Collagen triple helix repeat (20 copies), 0.0026 PF02865 STAT protein, protein interaction domain 0.0026 PF02864 STAT protein, DNA binding domain 0.0025 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0025 PF00432 Prenyltransferase and squalene oxidase repeat 0.0024 PF09396 Thrombin light chain 0.0021 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0020 PF01596 O-methyltransferase 0.0019 PF00324 Amino acid permease 0.0019 PF00821 Phosphoenolpyruvate carboxykinase 0.0017 PF00145 C-5 cytosine-specific DNA methylase 0.0017 PF01061 ABC-2 type transporter 0.0016 PF00071 Ras family 0.0014 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0013 PF00462 Glutaredoxin 0.0012 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0010 PF00656 Caspase domain 0.0010 PF01433 Peptidase family M1 0.0007 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0007 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0005 PF00341 Platelet-derived growth factor (PDGF), 0.0005 PF00105 Zinc finger, C4 type (two domains), 0.0005 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0004 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0003 PF07686 Immunoglobulin V-set domain 0.0001 PF00354 Pentaxin family 0.0001 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain SUB24 >= 1 F 0.2972 PF08070 DTHCT (NUC029), region 0.2972 PF00204 DNA gyrase B 0.2972 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1321 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1321 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1185 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0706 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0687 PF01735 Lysophospholipase catalytic domain 0.0667 PF00146 NADH dehydrogenase 0.0627 PF00191 Annexin 0.0617 PF00690 Cation transporter/ATPase, N-terminus 0.0617 PF00689 Cation transporting ATPase, C-terminus 0.0564 PF00194 Eukaryotic-type carbonic anhydrase 0.0563 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0550 PF00576 HIUase/Transthyretin family 0.0542 PF00989 PAS fold 0.0541 PF00122 E1-E2 ATPase 0.0487 PF02155 Glucocorticoid receptor 0.0469 PF00702 haloacid dehalogenase-like hydrolase 0.0449 PF00520 Ion transport protein 0.0448 PF00102 Protein-tyrosine phosphatase 0.0434 PF00027 Cyclic nucleotide-binding domain 0.0427 PF03073 TspO/MBR family 0.0400 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0395 PF02214 K+ channel tetramerisation domain 0.0377 PF02166 Androgen receptor 0.0366 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0355 PF00079 Serpin (serine protease inhibitor), 0.0336 PF00303 Thymidylate synthase 0.0325 PF00317 Ribonucleotide reductase, all-alpha domain 0.0325 PF02867 Ribonucleotide reductase, barrel domain 0.0325 PF03477 ATP cone domain 0.0270 PF01180 Dihydroorotate dehydrogenase 0.0250 PF00168 C2 domain 0.0241 PF02254 TrkA-N domain 0.0241 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0236 PF00757 Furin-like cysteine rich region 0.0236 PF01030 Receptor L domain 0.0211 PF03104 DNA polymerase family B, exonuclease domain 0.0211 PF00136 DNA polymerase family B 0.0211 PF08996 DNA Polymerase alpha zinc finger 0.0197 PF03098 Animal haem peroxidase 0.0192 PF00248 Aldo/keto reductase family 0.0187 PF00493 MCM2/3/5 family 0.0183 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0175 PF03530 Calcium-activated SK potassium channel 0.0175 PF02888 Calmodulin binding domain 0.0174 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0174 PF00631 GGL domain 0.0160 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0159 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0158 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0138 PF00028 Cadherin domain 0.0136 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0136 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0136 PF00533 BRCA1 C Terminus (BRCT), domain 0.0136 PF08063 PADR1 (NUC008), domain 0.0136 PF05406 WGR domain 0.0131 PF00069 Protein kinase domain 0.0130 PF02460 Patched family 0.0119 PF01007 Inward rectifier potassium channel 0.0119 PF03062 MBOAT family 0.0115 PF00654 Voltage gated chloride channel 0.0105 PF12491 Apolipoprotein B100 C terminal 0.0105 PF06448 Domain of Unknown Function (DUF1081), 0.0096 PF02196 Raf-like Ras-binding domain 0.0090 PF00489 Interleukin-6/G-CSF/MGF family 0.0089 PF01731 Arylesterase 0.0088 PF08403 Amino acid permease N-terminal 0.0084 PF00229 TNF(Tumour Necrosis Factor), family 0.0082 PF00273 Serum albumin family 0.0081 PF12497 Estrogen receptor beta 0.0077 PF07885 Ion channel 0.0070 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0070 PF02180 Bcl-2 homology region 4 0.0068 PF00060 Ligand-gated ion channel 0.0063 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0054 PF02159 Oestrogen receptor 0.0052 PF01347 Lipoprotein amino terminal region 0.0049 PF01094 Receptor family ligand binding region 0.0039 PF00554 Rel homology domain (RHD), 0.0034 PF08377 MAP2/Tau projection domain 0.0034 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0033 PF00058 Low-density lipoprotein receptor repeat class B 0.0032 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0032 PF02008 CXXC zinc finger domain 0.0032 PF01426 BAH domain 0.0032 PF06464 DMAP1-binding Domain 0.0031 PF00042 Globin 0.0030 PF00406 Adenylate kinase 0.0026 PF01017 STAT protein, all-alpha domain 0.0026 PF02865 STAT protein, protein interaction domain 0.0026 PF02864 STAT protein, DNA binding domain 0.0026 PF01391 Collagen triple helix repeat (20 copies), 0.0025 PF00432 Prenyltransferase and squalene oxidase repeat 0.0024 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0023 PF09396 Thrombin light chain 0.0020 PF01596 O-methyltransferase 0.0020 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0019 PF00324 Amino acid permease 0.0019 PF00821 Phosphoenolpyruvate carboxykinase 0.0017 PF01061 ABC-2 type transporter 0.0017 PF00145 C-5 cytosine-specific DNA methylase 0.0016 PF00071 Ras family 0.0013 PF00462 Glutaredoxin 0.0013 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0011 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0010 PF01433 Peptidase family M1 0.0009 PF00656 Caspase domain 0.0007 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0007 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0005 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0005 PF00341 Platelet-derived growth factor (PDGF), 0.0005 PF00105 Zinc finger, C4 type (two domains), 0.0004 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0003 PF07686 Immunoglobulin V-set domain 0.0001 PF00354 Pentaxin family 0.0001 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain SUB256 >= 1 aromatic ring 0.2949 PF00001 7 transmembrane receptor (rhodopsin family), 0.1416 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0980 PF00209 Sodium:neurotransmitter symporter family 0.0852 PF03098 Animal haem peroxidase 0.0784 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0784 PF00204 DNA gyrase B 0.0784 PF08070 DTHCT (NUC029), region 0.0666 PF06512 Sodium ion transport-associated 0.0576 PF00194 Eukaryotic-type carbonic anhydrase 0.0557 PF03073 TspO/MBR family 0.0511 PF00520 Ion transport protein 0.0355 PF00989 PAS fold 0.0317 PF00102 Protein-tyrosine phosphatase 0.0316 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0290 PF09396 Thrombin light chain 0.0289 PF00027 Cyclic nucleotide-binding domain 0.0287 PF00186 Dihydrofolate reductase 0.0279 PF00005 ABC transporter 0.0203 PF00069 Protein kinase domain 0.0201 PF01593 Flavin containing amine oxidoreductase 0.0201 PF00664 ABC transporter transmembrane region 0.0187 PF00576 HIUase/Transthyretin family 0.0126 PF01007 Inward rectifier potassium channel 0.0119 PF08403 Amino acid permease N-terminal 0.0089 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0085 PF00017 SH2 domain 0.0068 PF05649 Peptidase family M13 0.0068 PF01431 Peptidase family M13 0.0060 PF07884 Vitamin K epoxide reductase family 0.0056 PF00018 SH3 domain 0.0024 PF01061 ABC-2 type transporter 0.0021 PF08983 Domain of unknown function (DUF1856), 0.0019 PF00822 PMP-22/EMP/MP20/Claudin family 0.0013 PF01401 Angiotensin-converting enzyme 0.0012 PF12497 Estrogen receptor beta 0.0006 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0002 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0001 PF00042 Globin SUB52 >= 1 Al 0.2890 PF08702 Fibrinogen alpha/beta chain family 0.2890 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.1809 PF00273 Serum albumin family 0.1650 PF12160 Fibrinogen alpha C domain 0.1647 PF09396 Thrombin light chain 0.1254 PF00167 Fibroblast growth factor 0.1108 PF01459 Eukaryotic porin 0.0976 PF00079 Serpin (serine protease inhibitor), 0.0966 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0825 PF00051 Kringle domain 0.0800 PF00089 Trypsin 0.0494 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0488 PF02146 Sir2 family 0.0405 PF00024 PAN domain 0.0397 PF00405 Transferrin 0.0252 PF00854 POT family 0.0214 PF02806 Alpha amylase, C-terminal all-beta domain 0.0205 PF00690 Cation transporter/ATPase, N-terminus 0.0205 PF00689 Cation transporting ATPase, C-terminus 0.0195 PF00059 Lectin C-type domain 0.0182 PF00122 E1-E2 ATPase 0.0175 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0168 PF00128 Alpha amylase, catalytic domain 0.0139 PF00702 haloacid dehalogenase-like hydrolase 0.0128 PF00084 Sushi domain (SCR repeat), 0.0126 PF00002 7 transmembrane receptor (Secretin family), 0.0126 PF02793 Hormone receptor domain 0.0122 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0116 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0116 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0116 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0116 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0109 PF01055 Glycosyl hydrolases family 31 0.0109 PF00088 Trefoil (P-type), domain 0.0106 PF09193 Cholecystokinin A receptor, N-terminal 0.0101 PF01068 ATP dependent DNA ligase domain 0.0101 PF04679 ATP dependent DNA ligase C terminal region 0.0087 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0083 PF00188 Cysteine-rich secretory protein family 0.0083 PF00578 AhpC/TSA family 0.0083 PF01370 NAD dependent epimerase/dehydratase family 0.0083 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0079 PF01731 Arylesterase 0.0078 PF01323 DSBA-like thioredoxin domain 0.0076 PF03414 Glycosyltransferase family 6 0.0074 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0074 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0071 PF02259 FAT domain 0.0071 PF08771 Rapamycin binding domain 0.0071 PF02260 FATC domain 0.0066 PF02460 Patched family 0.0066 PF02180 Bcl-2 homology region 4 0.0066 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0063 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0062 PF03489 Saposin-like type B, region 2 0.0060 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0058 PF07677 A-macroglobulin receptor 0.0058 PF07678 A-macroglobulin complement component 0.0058 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0058 PF01835 MG2 domain 0.0056 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0056 PF03062 MBOAT family 0.0056 PF00439 Bromodomain 0.0053 PF06617 M-phase inducer phosphatase 0.0053 PF00581 Rhodanese-like domain 0.0047 PF03770 Inositol polyphosphate kinase 0.0047 PF03073 TspO/MBR family 0.0046 PF01652 Eukaryotic initiation factor 4E 0.0045 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0043 PF00169 PH domain 0.0039 PF00091 Tubulin/FtsZ family, GTPase domain 0.0039 PF03953 Tubulin C-terminal domain 0.0036 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0036 PF02233 NAD(P), transhydrogenase beta subunit 0.0036 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0034 PF02267 ADP-ribosyl cyclase 0.0033 PF08983 Domain of unknown function (DUF1856), 0.0029 PF00248 Aldo/keto reductase family 0.0027 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0026 PF00151 Lipase 0.0025 PF00106 short chain dehydrogenase 0.0025 PF05193 Peptidase M16 inactive domain 0.0025 PF00378 Enoyl-CoA hydratase/isomerase family 0.0025 PF00675 Insulinase (Peptidase family M16), 0.0024 PF02803 Thiolase, C-terminal domain 0.0024 PF00108 Thiolase, N-terminal domain 0.0024 PF00431 CUB domain 0.0021 PF00171 Aldehyde dehydrogenase family 0.0020 PF03360 Glycosyltransferase family 43 0.0019 PF00406 Adenylate kinase 0.0019 PF07645 Calcium-binding EGF domain 0.0018 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0017 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0017 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0016 PF00779 BTK motif 0.0014 PF01122 Eukaryotic cobalamin-binding protein 0.0013 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0013 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0011 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0011 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0011 PF01433 Peptidase family M1 0.0010 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0010 PF02223 Thymidylate kinase 0.0009 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0004 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0002 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0002 PF01852 START domain 0.0002 PF08659 KR domain 0.0002 PF00583 Acetyltransferase (GNAT), family 0.0002 PF03308 ArgK protein 0.0002 PF01642 Methylmalonyl-CoA mutase 0.0002 PF00698 Acyl transferase domain 0.0002 PF00975 Thioesterase domain 0.0002 PF01923 Cobalamin adenosyltransferase SUB356 C(~C)(:C) 0.2886 PF00001 7 transmembrane receptor (rhodopsin family), 0.1385 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0959 PF00209 Sodium:neurotransmitter symporter family 0.0834 PF03098 Animal haem peroxidase 0.0768 PF00204 DNA gyrase B 0.0768 PF08070 DTHCT (NUC029), region 0.0768 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0651 PF06512 Sodium ion transport-associated 0.0564 PF00194 Eukaryotic-type carbonic anhydrase 0.0545 PF03073 TspO/MBR family 0.0500 PF00520 Ion transport protein 0.0348 PF00989 PAS fold 0.0310 PF00102 Protein-tyrosine phosphatase 0.0309 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0283 PF00027 Cyclic nucleotide-binding domain 0.0283 PF09396 Thrombin light chain 0.0281 PF00186 Dihydrofolate reductase 0.0273 PF00005 ABC transporter 0.0199 PF00069 Protein kinase domain 0.0197 PF00664 ABC transporter transmembrane region 0.0197 PF01593 Flavin containing amine oxidoreductase 0.0183 PF00576 HIUase/Transthyretin family 0.0123 PF01007 Inward rectifier potassium channel 0.0117 PF08403 Amino acid permease N-terminal 0.0087 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0083 PF00017 SH2 domain 0.0066 PF05649 Peptidase family M13 0.0066 PF01431 Peptidase family M13 0.0059 PF07884 Vitamin K epoxide reductase family 0.0055 PF00018 SH3 domain 0.0023 PF01061 ABC-2 type transporter 0.0020 PF08983 Domain of unknown function (DUF1856), 0.0018 PF00822 PMP-22/EMP/MP20/Claudin family 0.0013 PF01401 Angiotensin-converting enzyme 0.0012 PF12497 Estrogen receptor beta 0.0005 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0002 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0001 PF00042 Globin SUB597 N=C-N-C-C 0.2867 PF00186 Dihydrofolate reductase 0.1893 PF01048 Phosphorylase superfamily 0.1517 PF00478 IMP dehydrogenase / GMP reductase domain 0.1350 PF00069 Protein kinase domain 0.1178 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0867 PF03073 TspO/MBR family 0.0859 PF00571 CBS domain 0.0826 PF00962 Adenosine/AMP deaminase 0.0596 PF00156 Phosphoribosyl transferase domain 0.0538 PF01590 GAF domain 0.0487 PF00106 short chain dehydrogenase 0.0477 PF08240 Alcohol dehydrogenase GroES-like domain 0.0470 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0374 PF00018 SH3 domain 0.0371 PF00107 Zinc-binding dehydrogenase 0.0348 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0348 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0335 PF00017 SH2 domain 0.0335 PF08919 F-actin binding 0.0308 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0308 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0308 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0306 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0240 PF00858 Amiloride-sensitive sodium channel 0.0216 PF00171 Aldehyde dehydrogenase family 0.0214 PF09396 Thrombin light chain 0.0210 PF00757 Furin-like cysteine rich region 0.0210 PF01030 Receptor L domain 0.0197 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0189 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0189 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0174 PF01268 Formate--tetrahydrofolate ligase 0.0157 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0157 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0125 PF01687 Riboflavin kinase 0.0112 PF00821 Phosphoenolpyruvate carboxykinase 0.0093 PF00501 AMP-binding enzyme 0.0074 PF01808 AICARFT/IMPCHase bienzyme 0.0038 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0038 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0036 PF02867 Ribonucleotide reductase, barrel domain 0.0036 PF03477 ATP cone domain 0.0036 PF00317 Ribonucleotide reductase, all-alpha domain 0.0029 PF02267 ADP-ribosyl cyclase 0.0022 PF01467 Cytidylyltransferase 0.0020 PF02223 Thymidylate kinase 0.0019 PF10397 Adenylosuccinate lyase C-terminus 0.0019 PF08996 DNA Polymerase alpha zinc finger 0.0019 PF00536 SAM domain (Sterile alpha motif), 0.0019 PF00136 DNA polymerase family B 0.0019 PF01404 Ephrin receptor ligand binding domain 0.0019 PF03104 DNA polymerase family B, exonuclease domain 0.0018 PF08676 MutL C terminal dimerisation domain 0.0018 PF00498 FHA domain 0.0018 PF12423 Kinesin protein 1B 0.0018 PF12473 Kinesin protein 0.0018 PF01119 DNA mismatch repair protein, C-terminal domain 0.0017 PF01652 Eukaryotic initiation factor 4E 0.0017 PF01575 MaoC like domain 0.0017 PF02036 SCP-2 sterol transfer family 0.0017 PF00970 Oxidoreductase FAD-binding domain 0.0014 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0012 PF01122 Eukaryotic cobalamin-binding protein 0.0005 PF01230 HIT domain SUB727 Sc1ccc(Cl)cc1 0.2851 PF00194 Eukaryotic-type carbonic anhydrase 0.1364 PF02254 TrkA-N domain 0.1364 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1174 PF08403 Amino acid permease N-terminal 0.0980 PF00001 7 transmembrane receptor (rhodopsin family), 0.0500 PF00324 Amino acid permease 0.0357 PF00689 Cation transporting ATPase, C-terminus 0.0357 PF00690 Cation transporter/ATPase, N-terminus 0.0314 PF00122 E1-E2 ATPase 0.0285 PF00520 Ion transport protein 0.0277 PF00702 haloacid dehalogenase-like hydrolase 0.0245 PF02038 ATP1G1/PLM/MAT8 family 0.0115 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0076 PF00043 Glutathione S-transferase, C-terminal domain 0.0072 PF02798 Glutathione S-transferase, N-terminal domain 0.0065 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0055 PF00822 PMP-22/EMP/MP20/Claudin family 0.0044 PF00357 Integrin alpha cytoplasmic region 0.0032 PF09396 Thrombin light chain 0.0029 PF08441 Integrin alpha 0.0026 PF01734 Patatin-like phospholipase 0.0024 PF00757 Furin-like cysteine rich region 0.0024 PF01030 Receptor L domain 0.0016 PF00102 Protein-tyrosine phosphatase 0.0014 PF01007 Inward rectifier potassium channel 0.0013 PF02146 Sir2 family 0.0010 PF01582 TIR domain 0.0010 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0010 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0010 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0009 PF02060 Slow voltage-gated potassium channel 0.0008 PF00042 Globin 0.0006 PF03520 KCNQ voltage-gated potassium channel 0.0006 PF00167 Fibroblast growth factor 0.0005 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0003 PF00305 Lipoxygenase 0.0003 PF00051 Kringle domain 0.0002 PF00045 Hemopexin 0.0002 PF01471 Putative peptidoglycan binding domain 0.0002 PF01916 Deoxyhypusine synthase 0.0001 PF00413 Matrixin 0.0001 PF01590 GAF domain 0.0001 PF00108 Thiolase, N-terminal domain 0.0001 PF02803 Thiolase, C-terminal domain 0.0001 PF08912 Rho Binding 0.0001 PF02185 Hr1 repeat SUB790 SC1CCC(Cl)CC1 0.2851 PF00194 Eukaryotic-type carbonic anhydrase 0.1364 PF02254 TrkA-N domain 0.1364 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1174 PF08403 Amino acid permease N-terminal 0.0980 PF00001 7 transmembrane receptor (rhodopsin family), 0.0500 PF00324 Amino acid permease 0.0357 PF00689 Cation transporting ATPase, C-terminus 0.0357 PF00690 Cation transporter/ATPase, N-terminus 0.0314 PF00122 E1-E2 ATPase 0.0285 PF00520 Ion transport protein 0.0277 PF00702 haloacid dehalogenase-like hydrolase 0.0245 PF02038 ATP1G1/PLM/MAT8 family 0.0115 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0076 PF00043 Glutathione S-transferase, C-terminal domain 0.0072 PF02798 Glutathione S-transferase, N-terminal domain 0.0065 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0055 PF00822 PMP-22/EMP/MP20/Claudin family 0.0044 PF00357 Integrin alpha cytoplasmic region 0.0032 PF09396 Thrombin light chain 0.0029 PF08441 Integrin alpha 0.0026 PF01734 Patatin-like phospholipase 0.0024 PF00757 Furin-like cysteine rich region 0.0024 PF01030 Receptor L domain 0.0016 PF00102 Protein-tyrosine phosphatase 0.0014 PF01007 Inward rectifier potassium channel 0.0013 PF02146 Sir2 family 0.0010 PF01582 TIR domain 0.0010 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0010 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0010 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0009 PF02060 Slow voltage-gated potassium channel 0.0008 PF00042 Globin 0.0006 PF00167 Fibroblast growth factor 0.0006 PF03520 KCNQ voltage-gated potassium channel 0.0005 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0003 PF00051 Kringle domain 0.0003 PF00305 Lipoxygenase 0.0002 PF01471 Putative peptidoglycan binding domain 0.0002 PF01916 Deoxyhypusine synthase 0.0002 PF00045 Hemopexin 0.0001 PF01590 GAF domain 0.0001 PF00413 Matrixin 0.0001 PF08912 Rho Binding 0.0001 PF00108 Thiolase, N-terminal domain 0.0001 PF02185 Hr1 repeat 0.0001 PF02803 Thiolase, C-terminal domain SUB471 C:C-C=C 0.2830 PF00001 7 transmembrane receptor (rhodopsin family), 0.1321 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0951 PF00209 Sodium:neurotransmitter symporter family 0.0870 PF03098 Animal haem peroxidase 0.0702 PF08070 DTHCT (NUC029), region 0.0702 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0702 PF00204 DNA gyrase B 0.0636 PF06512 Sodium ion transport-associated 0.0634 PF00194 Eukaryotic-type carbonic anhydrase 0.0555 PF00520 Ion transport protein 0.0538 PF03073 TspO/MBR family 0.0329 PF00989 PAS fold 0.0275 PF09396 Thrombin light chain 0.0275 PF00102 Protein-tyrosine phosphatase 0.0272 PF00027 Cyclic nucleotide-binding domain 0.0227 PF00186 Dihydrofolate reductase 0.0212 PF03953 Tubulin C-terminal domain 0.0212 PF00091 Tubulin/FtsZ family, GTPase domain 0.0205 PF00576 HIUase/Transthyretin family 0.0203 PF01593 Flavin containing amine oxidoreductase 0.0177 PF08403 Amino acid permease N-terminal 0.0174 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0157 PF01007 Inward rectifier potassium channel 0.0115 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0107 PF00005 ABC transporter 0.0076 PF02254 TrkA-N domain 0.0076 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0068 PF02159 Oestrogen receptor 0.0067 PF01431 Peptidase family M13 0.0067 PF07884 Vitamin K epoxide reductase family 0.0067 PF05649 Peptidase family M13 0.0058 PF00664 ABC transporter transmembrane region 0.0054 PF01401 Angiotensin-converting enzyme 0.0045 PF00017 SH2 domain 0.0028 PF00069 Protein kinase domain 0.0027 PF12497 Estrogen receptor beta 0.0027 PF00822 PMP-22/EMP/MP20/Claudin family 0.0021 PF08983 Domain of unknown function (DUF1856), 0.0021 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0019 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0015 PF00018 SH3 domain 0.0012 PF00042 Globin 0.0002 PF00067 Cytochrome P450 SUB521 C=C-C:C 0.2830 PF00001 7 transmembrane receptor (rhodopsin family), 0.1321 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0951 PF00209 Sodium:neurotransmitter symporter family 0.0870 PF03098 Animal haem peroxidase 0.0702 PF08070 DTHCT (NUC029), region 0.0702 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0702 PF00204 DNA gyrase B 0.0636 PF06512 Sodium ion transport-associated 0.0634 PF00194 Eukaryotic-type carbonic anhydrase 0.0555 PF00520 Ion transport protein 0.0538 PF03073 TspO/MBR family 0.0329 PF00989 PAS fold 0.0275 PF00102 Protein-tyrosine phosphatase 0.0275 PF09396 Thrombin light chain 0.0272 PF00027 Cyclic nucleotide-binding domain 0.0227 PF00186 Dihydrofolate reductase 0.0212 PF00091 Tubulin/FtsZ family, GTPase domain 0.0212 PF03953 Tubulin C-terminal domain 0.0205 PF00576 HIUase/Transthyretin family 0.0203 PF01593 Flavin containing amine oxidoreductase 0.0177 PF08403 Amino acid permease N-terminal 0.0174 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0157 PF01007 Inward rectifier potassium channel 0.0115 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0107 PF00005 ABC transporter 0.0076 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0076 PF02254 TrkA-N domain 0.0068 PF02159 Oestrogen receptor 0.0067 PF01431 Peptidase family M13 0.0067 PF07884 Vitamin K epoxide reductase family 0.0067 PF05649 Peptidase family M13 0.0058 PF00664 ABC transporter transmembrane region 0.0054 PF01401 Angiotensin-converting enzyme 0.0045 PF00017 SH2 domain 0.0028 PF00069 Protein kinase domain 0.0027 PF00822 PMP-22/EMP/MP20/Claudin family 0.0027 PF12497 Estrogen receptor beta 0.0021 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0021 PF08983 Domain of unknown function (DUF1856), 0.0019 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0015 PF00018 SH3 domain 0.0012 PF00042 Globin 0.0002 PF00067 Cytochrome P450 SUB385 C(:C)(:C) 0.2797 PF00001 7 transmembrane receptor (rhodopsin family), 0.1343 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0929 PF00209 Sodium:neurotransmitter symporter family 0.0808 PF03098 Animal haem peroxidase 0.0744 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0744 PF08070 DTHCT (NUC029), region 0.0744 PF00204 DNA gyrase B 0.0631 PF06512 Sodium ion transport-associated 0.0546 PF00194 Eukaryotic-type carbonic anhydrase 0.0529 PF03073 TspO/MBR family 0.0485 PF00520 Ion transport protein 0.0337 PF00989 PAS fold 0.0301 PF00102 Protein-tyrosine phosphatase 0.0300 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0275 PF09396 Thrombin light chain 0.0274 PF00027 Cyclic nucleotide-binding domain 0.0272 PF00186 Dihydrofolate reductase 0.0265 PF00005 ABC transporter 0.0193 PF00069 Protein kinase domain 0.0191 PF00664 ABC transporter transmembrane region 0.0191 PF01593 Flavin containing amine oxidoreductase 0.0178 PF00576 HIUase/Transthyretin family 0.0119 PF01007 Inward rectifier potassium channel 0.0113 PF08403 Amino acid permease N-terminal 0.0084 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0081 PF00017 SH2 domain 0.0064 PF01431 Peptidase family M13 0.0064 PF05649 Peptidase family M13 0.0057 PF07884 Vitamin K epoxide reductase family 0.0054 PF00018 SH3 domain 0.0022 PF01061 ABC-2 type transporter 0.0020 PF08983 Domain of unknown function (DUF1856), 0.0018 PF00822 PMP-22/EMP/MP20/Claudin family 0.0013 PF01401 Angiotensin-converting enzyme 0.0012 PF12497 Estrogen receptor beta 0.0005 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0002 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0001 PF00042 Globin SUB342 C(~C)(~C)(~O) 0.2796 PF02159 Oestrogen receptor 0.2078 PF00105 Zinc finger, C4 type (two domains), 0.2042 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1200 PF00191 Annexin 0.1125 PF02155 Glucocorticoid receptor 0.1023 PF00001 7 transmembrane receptor (rhodopsin family), 0.0999 PF08070 DTHCT (NUC029), region 0.0999 PF00204 DNA gyrase B 0.0999 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0733 PF02161 Progesterone receptor 0.0590 PF00091 Tubulin/FtsZ family, GTPase domain 0.0590 PF03953 Tubulin C-terminal domain 0.0585 PF00079 Serpin (serine protease inhibitor), 0.0569 PF01735 Lysophospholipase catalytic domain 0.0550 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0421 PF00005 ABC transporter 0.0395 PF08384 Pro-opiomelanocortin, N-terminal region 0.0395 PF08035 Opioids neuropeptide 0.0395 PF00976 Corticotropin ACTH domain 0.0391 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0390 PF00989 PAS fold 0.0381 PF12497 Estrogen receptor beta 0.0381 PF02166 Androgen receptor 0.0372 PF00664 ABC transporter transmembrane region 0.0327 PF00027 Cyclic nucleotide-binding domain 0.0248 PF03414 Glycosyltransferase family 6 0.0238 PF00168 C2 domain 0.0231 PF02806 Alpha amylase, C-terminal all-beta domain 0.0208 PF00273 Serum albumin family 0.0172 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0164 PF01477 PLAT/LH2 domain 0.0152 PF00822 PMP-22/EMP/MP20/Claudin family 0.0137 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0124 PF00067 Cytochrome P450 0.0095 PF03098 Animal haem peroxidase 0.0092 PF00128 Alpha amylase, catalytic domain 0.0091 PF07966 A1 Propeptide 0.0088 PF11825 Protein of unknown function (DUF3345), 0.0075 PF01401 Angiotensin-converting enzyme 0.0071 PF00026 Eukaryotic aspartyl protease 0.0066 PF01048 Phosphorylase superfamily 0.0062 PF00305 Lipoxygenase 0.0053 PF00059 Lectin C-type domain 0.0051 PF07648 Kazal-type serine protease inhibitor domain 0.0050 PF02223 Thymidylate kinase 0.0044 PF00151 Lipase 0.0040 PF00183 Hsp90 protein 0.0037 PF00303 Thymidylate synthase 0.0032 PF00106 short chain dehydrogenase 0.0030 PF01061 ABC-2 type transporter 0.0028 PF00340 Interleukin-1 / 18 0.0028 PF02394 Interleukin-1 propeptide 0.0026 PF00167 Fibroblast growth factor 0.0025 PF08763 Voltage gated calcium channel IQ domain 0.0025 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0023 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0022 PF03770 Inositol polyphosphate kinase 0.0020 PF08441 Integrin alpha 0.0018 PF00704 Glycosyl hydrolases family 18 0.0018 PF01607 Chitin binding Peritrophin-A domain 0.0017 PF00643 B-box zinc finger 0.0017 PF01467 Cytidylyltransferase 0.0015 PF00229 TNF(Tumour Necrosis Factor), family 0.0014 PF00084 Sushi domain (SCR repeat), 0.0014 PF02267 ADP-ribosyl cyclase 0.0013 PF00349 Hexokinase 0.0013 PF03727 Hexokinase 0.0013 PF00171 Aldehyde dehydrogenase family 0.0012 PF07654 Immunoglobulin C1-set domain 0.0012 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0012 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0011 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.0011 PF01370 NAD dependent epimerase/dehydratase family 0.0010 PF01532 Glycosyl hydrolase family 47 0.0008 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0008 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0008 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0007 PF08240 Alcohol dehydrogenase GroES-like domain 0.0007 PF02260 FATC domain 0.0007 PF02259 FAT domain 0.0007 PF08771 Rapamycin binding domain 0.0005 PF00650 CRAL/TRIO domain 0.0005 PF03765 CRAL/TRIO, N-terminus 0.0004 PF00143 Interferon alpha/beta domain 0.0004 PF00107 Zinc-binding dehydrogenase 0.0004 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0004 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0004 PF02180 Bcl-2 homology region 4 0.0004 PF00248 Aldo/keto reductase family 0.0003 PF00071 Ras family 0.0003 PF01687 Riboflavin kinase 0.0002 PF01230 HIT domain 0.0002 PF00571 CBS domain 0.0002 PF01842 ACT domain 0.0002 PF01122 Eukaryotic cobalamin-binding protein 0.0001 PF03360 Glycosyltransferase family 43 0.0001 PF01055 Glycosyl hydrolases family 31 0.0001 PF00088 Trefoil (P-type), domain SUB574 O-C-C=C 0.2744 PF02159 Oestrogen receptor 0.2189 PF00001 7 transmembrane receptor (rhodopsin family), 0.1642 PF00204 DNA gyrase B 0.1642 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1642 PF08070 DTHCT (NUC029), region 0.1304 PF00576 HIUase/Transthyretin family 0.1158 PF00105 Zinc finger, C4 type (two domains), 0.1122 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0832 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0612 PF12497 Estrogen receptor beta 0.0600 PF00989 PAS fold 0.0474 PF03098 Animal haem peroxidase 0.0448 PF00027 Cyclic nucleotide-binding domain 0.0426 PF00664 ABC transporter transmembrane region 0.0410 PF00005 ABC transporter 0.0380 PF11825 Protein of unknown function (DUF3345), 0.0355 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0353 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0323 PF08674 Acetylcholinesterase tetramerisation domain 0.0307 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0275 PF00135 Carboxylesterase 0.0265 PF00266 Aminotransferase class-V 0.0216 PF01596 O-methyltransferase 0.0216 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0199 PF00186 Dihydrofolate reductase 0.0189 PF01477 PLAT/LH2 domain 0.0186 PF07884 Vitamin K epoxide reductase family 0.0172 PF00702 haloacid dehalogenase-like hydrolase 0.0166 PF00155 Aminotransferase class I and II 0.0154 PF08035 Opioids neuropeptide 0.0154 PF08384 Pro-opiomelanocortin, N-terminal region 0.0154 PF00976 Corticotropin ACTH domain 0.0117 PF00656 Caspase domain 0.0110 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0107 PF00183 Hsp90 protein 0.0106 PF00305 Lipoxygenase 0.0105 PF08983 Domain of unknown function (DUF1856), 0.0096 PF00643 B-box zinc finger 0.0096 PF00273 Serum albumin family 0.0096 PF08441 Integrin alpha 0.0096 PF03765 CRAL/TRIO, N-terminus 0.0096 PF00650 CRAL/TRIO domain 0.0081 PF00068 Phospholipase A2 0.0068 PF01588 Putative tRNA binding domain 0.0068 PF00294 pfkB family carbohydrate kinase 0.0068 PF03062 MBOAT family 0.0068 PF00340 Interleukin-1 / 18 0.0068 PF02394 Interleukin-1 propeptide 0.0054 PF00357 Integrin alpha cytoplasmic region 0.0019 PF07885 Ion channel 0.0019 PF00291 Pyridoxal-phosphate dependent enzyme 0.0016 PF00102 Protein-tyrosine phosphatase 0.0015 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0015 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0015 PF00151 Lipase 0.0012 PF07966 A1 Propeptide SUB813 NC1CC(N)CCC1 0.2719 PF00204 DNA gyrase B 0.2719 PF08070 DTHCT (NUC029), region 0.2719 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1235 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0339 PF00273 Serum albumin family 0.0310 PF00091 Tubulin/FtsZ family, GTPase domain 0.0310 PF03953 Tubulin C-terminal domain 0.0240 PF00102 Protein-tyrosine phosphatase 0.0231 PF00576 HIUase/Transthyretin family 0.0174 PF00005 ABC transporter 0.0173 PF09396 Thrombin light chain 0.0173 PF00405 Transferrin 0.0163 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0155 PF01061 ABC-2 type transporter 0.0127 PF07884 Vitamin K epoxide reductase family 0.0124 PF00664 ABC transporter transmembrane region 0.0116 PF00754 F5/8 type C domain 0.0109 PF00017 SH2 domain 0.0106 PF08919 F-actin binding 0.0100 PF03098 Animal haem peroxidase 0.0094 PF01735 Lysophospholipase catalytic domain 0.0093 PF00018 SH3 domain 0.0091 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0080 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0079 PF01187 Macrophage migration inhibitory factor (MIF), 0.0076 PF00305 Lipoxygenase 0.0075 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0073 PF03957 Jun-like transcription factor 0.0073 PF00079 Serpin (serine protease inhibitor), 0.0071 PF03171 2OG-Fe(II), oxygenase superfamily 0.0070 PF00291 Pyridoxal-phosphate dependent enzyme 0.0067 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0063 PF01477 PLAT/LH2 domain 0.0063 PF00656 Caspase domain 0.0062 PF00266 Aminotransferase class-V 0.0061 PF00390 Malic enzyme, N-terminal domain 0.0061 PF03949 Malic enzyme, NAD binding domain 0.0060 PF00043 Glutathione S-transferase, C-terminal domain 0.0060 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0059 PF02260 FATC domain 0.0059 PF02259 FAT domain 0.0059 PF08771 Rapamycin binding domain 0.0059 PF02155 Glucocorticoid receptor 0.0059 PF00168 C2 domain 0.0057 PF02798 Glutathione S-transferase, N-terminal domain 0.0055 PF00493 MCM2/3/5 family 0.0055 PF02394 Interleukin-1 propeptide 0.0055 PF00340 Interleukin-1 / 18 0.0054 PF00229 TNF(Tumour Necrosis Factor), family 0.0051 PF00341 Platelet-derived growth factor (PDGF), 0.0051 PF01023 S-100/ICaBP type calcium binding domain 0.0051 PF01347 Lipoprotein amino terminal region 0.0049 PF01180 Dihydroorotate dehydrogenase 0.0046 PF02803 Thiolase, C-terminal domain 0.0046 PF00108 Thiolase, N-terminal domain 0.0046 PF00155 Aminotransferase class I and II 0.0045 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0045 PF00975 Thioesterase domain 0.0045 PF08659 KR domain 0.0045 PF00698 Acyl transferase domain 0.0045 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0044 PF00271 Helicase conserved C-terminal domain 0.0044 PF00377 Prion/Doppel alpha-helical domain 0.0044 PF00040 Fibronectin type II domain 0.0043 PF00989 PAS fold 0.0043 PF00085 Thioredoxin 0.0042 PF00170 bZIP transcription factor 0.0042 PF01202 Shikimate kinase 0.0041 PF00071 Ras family 0.0040 PF02059 Interleukin-3 0.0040 PF00002 7 transmembrane receptor (Secretin family), 0.0040 PF02793 Hormone receptor domain 0.0039 PF06448 Domain of Unknown Function (DUF1081), 0.0039 PF00191 Annexin 0.0039 PF12491 Apolipoprotein B100 C terminal 0.0039 PF00176 SNF2 family N-terminal domain 0.0039 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0037 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0036 PF00755 Choline/Carnitine o-acyltransferase 0.0036 PF01391 Collagen triple helix repeat (20 copies), 0.0034 PF03062 MBOAT family 0.0034 PF00027 Cyclic nucleotide-binding domain 0.0033 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0033 PF02525 Flavodoxin-like fold 0.0032 PF00058 Low-density lipoprotein receptor repeat class B 0.0032 PF04679 ATP dependent DNA ligase C terminal region 0.0032 PF01068 ATP dependent DNA ligase domain 0.0031 PF02180 Bcl-2 homology region 4 0.0031 PF00781 Diacylglycerol kinase catalytic domain 0.0031 PF03034 Phosphatidyl serine synthase 0.0031 PF02824 TGS domain 0.0031 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0031 PF00609 Diacylglycerol kinase accessory domain 0.0031 PF02025 Interleukin 5 0.0031 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0031 PF08742 C8 domain 0.0031 PF00094 von Willebrand factor type D domain 0.0031 PF01731 Arylesterase 0.0030 PF02375 jmjN domain 0.0030 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0030 PF00628 PHD-finger 0.0030 PF00274 Fructose-bisphosphate aldolase class-I 0.0030 PF02373 JmjC domain 0.0030 PF00860 Permease family 0.0030 PF08429 PLU-1-like protein 0.0030 PF01753 MYND finger 0.0030 PF01388 ARID/BRIGHT DNA binding domain 0.0030 PF02928 C5HC2 zinc finger 0.0030 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0030 PF00183 Hsp90 protein 0.0030 PF00342 Phosphoglucose isomerase 0.0029 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0029 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0028 PF00464 Serine hydroxymethyltransferase 0.0028 PF01596 O-methyltransferase 0.0027 PF00057 Low-density lipoprotein receptor domain class A 0.0026 PF00343 Carbohydrate phosphorylase 0.0026 PF01425 Amidase 0.0026 PF01429 Methyl-CpG binding domain 0.0025 PF03476 MOSC N-terminal beta barrel domain 0.0025 PF00654 Voltage gated chloride channel 0.0025 PF03473 MOSC domain 0.0025 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0024 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0023 PF01403 Sema domain 0.0023 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0023 PF00186 Dihydrofolate reductase 0.0023 PF01833 IPT/TIG domain 0.0023 PF03351 DOMON domain 0.0023 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0023 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0023 PF01437 Plexin repeat 0.0023 PF00717 Peptidase S24-like 0.0022 PF11404 Potassium voltage-gated channel 0.0022 PF01130 CD36 family 0.0022 PF09193 Cholecystokinin A receptor, N-terminal 0.0022 PF00246 Zinc carboxypeptidase 0.0022 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0022 PF00969 Class II histocompatibility antigen, beta domain 0.0022 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0022 PF02666 Phosphatidylserine decarboxylase 0.0022 PF00270 DEAD/DEAH box helicase 0.0022 PF02403 Seryl-tRNA synthetase N-terminal domain 0.0022 PF07647 SAM domain (Sterile alpha motif), 0.0021 PF00550 Phosphopantetheine attachment site 0.0021 PF00554 Rel homology domain (RHD), 0.0020 PF00051 Kringle domain 0.0020 PF03623 Focal adhesion targeting region 0.0019 PF02898 Nitric oxide synthase, oxygenase domain 0.0018 PF03360 Glycosyltransferase family 43 0.0017 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.0017 PF00294 pfkB family carbohydrate kinase 0.0016 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0016 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0015 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0015 PF02347 Glycine cleavage system P-protein 0.0015 PF01212 Beta-eliminating lyase 0.0015 PF01168 Alanine racemase, N-terminal domain 0.0015 PF07690 Major Facilitator Superfamily 0.0014 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 0.0014 PF00373 FERM central domain 0.0013 PF00020 TNFR/NGFR cysteine-rich region 0.0013 PF00151 Lipase 0.0012 PF00489 Interleukin-6/G-CSF/MGF family 0.0012 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0012 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0012 PF00688 TGF-beta propeptide 0.0012 PF00019 Transforming growth factor beta like domain 0.0012 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0012 PF00714 Interferon gamma 0.0012 PF00028 Cadherin domain 0.0011 PF00682 HMGL-like 0.0010 PF00202 Aminotransferase class-III 0.0009 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0009 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0009 PF00533 BRCA1 C Terminus (BRCT), domain 0.0009 PF05406 WGR domain 0.0009 PF08063 PADR1 (NUC008), domain 0.0009 PF01462 Leucine rich repeat N-terminal domain 0.0008 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0007 PF00619 Caspase recruitment domain 0.0007 PF00571 CBS domain 0.0007 PF00787 PX domain 0.0006 PF03129 Anticodon binding domain 0.0006 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0006 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0006 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0006 PF00792 Phosphoinositide 3-kinase C2 0.0006 PF00794 PI3-kinase family, ras-binding domain 0.0006 PF00432 Prenyltransferase and squalene oxidase repeat 0.0006 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0006 PF00622 SPRY domain 0.0006 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0006 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0006 PF04961 Formiminotransferase-cyclodeaminase 0.0006 PF02971 Formiminotransferase domain 0.0006 PF02460 Patched family 0.0005 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0005 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0005 PF01067 Calpain large subunit, domain III 0.0005 PF00354 Pentaxin family 0.0005 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0005 PF00648 Calpain family cysteine protease 0.0005 PF00074 Pancreatic ribonuclease 0.0005 PF07648 Kazal-type serine protease inhibitor domain 0.0005 PF00024 PAN domain 0.0004 PF02815 MIR domain 0.0004 PF03024 Folate receptor family 0.0004 PF06459 Ryanodine Receptor TM 4-6 0.0004 PF08454 RyR and IP3R Homology associated 0.0004 PF02758 PAAD/DAPIN/Pyrin domain 0.0004 PF08709 Inositol 1,4,5-trisphosphate/ryanodine receptor 0.0004 PF01365 RIH domain 0.0004 PF00433 Protein kinase C terminal domain 0.0004 PF02210 Laminin G domain 0.0004 PF00227 Proteasome subunit 0.0004 PF04756 OST3 / OST6 family 0.0004 PF02026 RyR domain 0.0003 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0003 PF00025 ADP-ribosylation factor family 0.0002 PF00089 Trypsin 0.0002 PF00067 Cytochrome P450 0.0002 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0002 PF00531 Death domain 0.0002 PF08725 Integrin beta cytoplasmic domain 0.0001 PF00675 Insulinase (Peptidase family M16), 0.0001 PF05193 Peptidase M16 inactive domain SUB193 >= 3 any ring size 6 0.2688 PF02159 Oestrogen receptor 0.1947 PF00105 Zinc finger, C4 type (two domains), 0.1929 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1688 PF00001 7 transmembrane receptor (rhodopsin family), 0.1648 PF08070 DTHCT (NUC029), region 0.1648 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1648 PF00204 DNA gyrase B 0.1357 PF00191 Annexin 0.1243 PF02155 Glucocorticoid receptor 0.1053 PF02161 Progesterone receptor 0.0752 PF02166 Androgen receptor 0.0691 PF01735 Lysophospholipase catalytic domain 0.0679 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0558 PF00079 Serpin (serine protease inhibitor), 0.0426 PF00976 Corticotropin ACTH domain 0.0426 PF08384 Pro-opiomelanocortin, N-terminal region 0.0426 PF08035 Opioids neuropeptide 0.0360 PF12497 Estrogen receptor beta 0.0329 PF00005 ABC transporter 0.0316 PF01401 Angiotensin-converting enzyme 0.0301 PF00664 ABC transporter transmembrane region 0.0279 PF09396 Thrombin light chain 0.0276 PF00168 C2 domain 0.0217 PF00091 Tubulin/FtsZ family, GTPase domain 0.0217 PF03953 Tubulin C-terminal domain 0.0209 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0206 PF00989 PAS fold 0.0186 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0163 PF00186 Dihydrofolate reductase 0.0158 PF07884 Vitamin K epoxide reductase family 0.0154 PF00027 Cyclic nucleotide-binding domain 0.0098 PF00042 Globin 0.0078 PF00305 Lipoxygenase 0.0077 PF11825 Protein of unknown function (DUF3345), 0.0076 PF00051 Kringle domain 0.0075 PF00067 Cytochrome P450 0.0075 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0064 PF01061 ABC-2 type transporter 0.0061 PF00643 B-box zinc finger 0.0049 PF00340 Interleukin-1 / 18 0.0049 PF02394 Interleukin-1 propeptide 0.0048 PF00229 TNF(Tumour Necrosis Factor), family 0.0045 PF07648 Kazal-type serine protease inhibitor domain 0.0044 PF04622 ERG2 and Sigma1 receptor like protein 0.0040 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0035 PF00554 Rel homology domain (RHD), 0.0033 PF06327 Domain of Unknown Function (DUF1053), 0.0033 PF01477 PLAT/LH2 domain 0.0031 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0029 PF00357 Integrin alpha cytoplasmic region 0.0026 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0024 PF08441 Integrin alpha 0.0022 PF03765 CRAL/TRIO, N-terminus 0.0022 PF00650 CRAL/TRIO domain 0.0021 PF07885 Ion channel 0.0018 PF03062 MBOAT family 0.0018 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0017 PF02259 FAT domain 0.0017 PF08771 Rapamycin binding domain 0.0017 PF02260 FATC domain 0.0013 PF00212 Atrial natriuretic peptide 0.0012 PF00341 Platelet-derived growth factor (PDGF), 0.0005 PF02180 Bcl-2 homology region 4 0.0005 PF00452 Apoptosis regulator proteins, Bcl-2 family SUB2 >= 8 H 0.2664 PF00001 7 transmembrane receptor (rhodopsin family), 0.1486 PF00105 Zinc finger, C4 type (two domains), 0.1478 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1396 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.1304 PF02159 Oestrogen receptor 0.0848 PF00209 Sodium:neurotransmitter symporter family 0.0586 PF03098 Animal haem peroxidase 0.0549 PF08070 DTHCT (NUC029), region 0.0549 PF00204 DNA gyrase B 0.0549 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0280 PF03953 Tubulin C-terminal domain 0.0280 PF00091 Tubulin/FtsZ family, GTPase domain 0.0279 PF00989 PAS fold 0.0229 PF09396 Thrombin light chain 0.0221 PF00027 Cyclic nucleotide-binding domain 0.0218 PF00005 ABC transporter 0.0198 PF00067 Cytochrome P450 0.0186 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0186 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0155 PF00664 ABC transporter transmembrane region 0.0081 PF00273 Serum albumin family 0.0079 PF02161 Progesterone receptor 0.0070 PF01593 Flavin containing amine oxidoreductase 0.0060 PF03073 TspO/MBR family 0.0050 PF12497 Estrogen receptor beta 0.0045 PF11825 Protein of unknown function (DUF3345), 0.0037 PF02166 Androgen receptor 0.0017 PF00061 Lipocalin / cytosolic fatty-acid binding protein family SUB417 C=C 0.2653 PF00001 7 transmembrane receptor (rhodopsin family), 0.1129 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.1094 PF03098 Animal haem peroxidase 0.0989 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0986 PF00105 Zinc finger, C4 type (two domains), 0.0933 PF02159 Oestrogen receptor 0.0683 PF00209 Sodium:neurotransmitter symporter family 0.0533 PF06512 Sodium ion transport-associated 0.0357 PF03073 TspO/MBR family 0.0299 PF09396 Thrombin light chain 0.0252 PF00005 ABC transporter 0.0246 PF00191 Annexin 0.0244 PF00989 PAS fold 0.0208 PF00067 Cytochrome P450 0.0205 PF00520 Ion transport protein 0.0203 PF00664 ABC transporter transmembrane region 0.0196 PF00027 Cyclic nucleotide-binding domain 0.0144 PF02155 Glucocorticoid receptor 0.0117 PF01593 Flavin containing amine oxidoreductase 0.0116 PF02161 Progesterone receptor 0.0084 PF00186 Dihydrofolate reductase 0.0079 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0060 PF01007 Inward rectifier potassium channel 0.0035 PF01735 Lysophospholipase catalytic domain 0.0031 PF11825 Protein of unknown function (DUF3345), 0.0026 PF00017 SH2 domain 0.0021 PF12497 Estrogen receptor beta SUB12 >= 8 C 0.2652 PF00001 7 transmembrane receptor (rhodopsin family), 0.1129 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.1093 PF03098 Animal haem peroxidase 0.0988 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0986 PF00105 Zinc finger, C4 type (two domains), 0.0932 PF02159 Oestrogen receptor 0.0682 PF00209 Sodium:neurotransmitter symporter family 0.0533 PF06512 Sodium ion transport-associated 0.0357 PF03073 TspO/MBR family 0.0299 PF09396 Thrombin light chain 0.0251 PF00005 ABC transporter 0.0246 PF00191 Annexin 0.0244 PF00989 PAS fold 0.0207 PF00067 Cytochrome P450 0.0205 PF00520 Ion transport protein 0.0203 PF00664 ABC transporter transmembrane region 0.0196 PF00027 Cyclic nucleotide-binding domain 0.0144 PF02155 Glucocorticoid receptor 0.0117 PF01593 Flavin containing amine oxidoreductase 0.0116 PF02161 Progesterone receptor 0.0084 PF00186 Dihydrofolate reductase 0.0079 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0060 PF01007 Inward rectifier potassium channel 0.0035 PF01735 Lysophospholipase catalytic domain 0.0031 PF11825 Protein of unknown function (DUF3345), 0.0026 PF00017 SH2 domain 0.0021 PF12497 Estrogen receptor beta SUB371 C(~H)(:C) 0.2634 PF00001 7 transmembrane receptor (rhodopsin family), 0.1229 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0885 PF00209 Sodium:neurotransmitter symporter family 0.0810 PF03098 Animal haem peroxidase 0.0654 PF00204 DNA gyrase B 0.0654 PF08070 DTHCT (NUC029), region 0.0654 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0592 PF06512 Sodium ion transport-associated 0.0590 PF00194 Eukaryotic-type carbonic anhydrase 0.0517 PF00520 Ion transport protein 0.0501 PF03073 TspO/MBR family 0.0307 PF00989 PAS fold 0.0256 PF00102 Protein-tyrosine phosphatase 0.0256 PF09396 Thrombin light chain 0.0253 PF00027 Cyclic nucleotide-binding domain 0.0211 PF00186 Dihydrofolate reductase 0.0197 PF00091 Tubulin/FtsZ family, GTPase domain 0.0197 PF03953 Tubulin C-terminal domain 0.0191 PF00576 HIUase/Transthyretin family 0.0189 PF01593 Flavin containing amine oxidoreductase 0.0164 PF08403 Amino acid permease N-terminal 0.0162 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0146 PF01007 Inward rectifier potassium channel 0.0107 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0100 PF00005 ABC transporter 0.0071 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0071 PF02254 TrkA-N domain 0.0064 PF02159 Oestrogen receptor 0.0062 PF07884 Vitamin K epoxide reductase family 0.0062 PF01431 Peptidase family M13 0.0062 PF05649 Peptidase family M13 0.0054 PF00664 ABC transporter transmembrane region 0.0051 PF01401 Angiotensin-converting enzyme 0.0042 PF00017 SH2 domain 0.0026 PF12497 Estrogen receptor beta 0.0026 PF00069 Protein kinase domain 0.0026 PF00822 PMP-22/EMP/MP20/Claudin family 0.0019 PF08983 Domain of unknown function (DUF1856), 0.0019 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0018 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0014 PF00018 SH3 domain 0.0011 PF00042 Globin 0.0002 PF00067 Cytochrome P450 SUB604 C-C:C:C-C 0.2628 PF00001 7 transmembrane receptor (rhodopsin family), 0.1259 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0874 PF00209 Sodium:neurotransmitter symporter family 0.0761 PF03098 Animal haem peroxidase 0.0696 PF08070 DTHCT (NUC029), region 0.0696 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0696 PF00204 DNA gyrase B 0.0593 PF06512 Sodium ion transport-associated 0.0525 PF00194 Eukaryotic-type carbonic anhydrase 0.0497 PF03073 TspO/MBR family 0.0460 PF00520 Ion transport protein 0.0316 PF00989 PAS fold 0.0280 PF00102 Protein-tyrosine phosphatase 0.0274 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0258 PF09396 Thrombin light chain 0.0258 PF00027 Cyclic nucleotide-binding domain 0.0254 PF00186 Dihydrofolate reductase 0.0242 PF00005 ABC transporter 0.0180 PF01593 Flavin containing amine oxidoreductase 0.0174 PF00069 Protein kinase domain 0.0173 PF00664 ABC transporter transmembrane region 0.0168 PF00576 HIUase/Transthyretin family 0.0115 PF01007 Inward rectifier potassium channel 0.0110 PF08403 Amino acid permease N-terminal 0.0081 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0075 PF00017 SH2 domain 0.0061 PF05649 Peptidase family M13 0.0061 PF01431 Peptidase family M13 0.0055 PF07884 Vitamin K epoxide reductase family 0.0049 PF00018 SH3 domain 0.0020 PF01061 ABC-2 type transporter 0.0019 PF08983 Domain of unknown function (DUF1856), 0.0018 PF00822 PMP-22/EMP/MP20/Claudin family 0.0015 PF01401 Angiotensin-converting enzyme 0.0013 PF12497 Estrogen receptor beta 0.0006 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0005 PF02254 TrkA-N domain 0.0005 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0002 PF00042 Globin 0.0002 PF02159 Oestrogen receptor 0.0001 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB625 O=C-C:C-N 0.2592 PF00204 DNA gyrase B 0.2592 PF08070 DTHCT (NUC029), region 0.2592 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1264 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0822 PF00102 Protein-tyrosine phosphatase 0.0518 PF01048 Phosphorylase superfamily 0.0500 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0333 PF00303 Thymidylate synthase 0.0301 PF01590 GAF domain 0.0290 PF00576 HIUase/Transthyretin family 0.0284 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0262 PF02525 Flavodoxin-like fold 0.0244 PF00533 BRCA1 C Terminus (BRCT), domain 0.0244 PF05406 WGR domain 0.0244 PF08063 PADR1 (NUC008), domain 0.0244 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0244 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0235 PF00821 Phosphoenolpyruvate carboxykinase 0.0230 PF01467 Cytidylyltransferase 0.0227 PF01268 Formate--tetrahydrofolate ligase 0.0215 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0215 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0204 PF01808 AICARFT/IMPCHase bienzyme 0.0195 PF00107 Zinc-binding dehydrogenase 0.0193 PF00106 short chain dehydrogenase 0.0188 PF08240 Alcohol dehydrogenase GroES-like domain 0.0184 PF00071 Ras family 0.0176 PF00248 Aldo/keto reductase family 0.0161 PF00858 Amiloride-sensitive sodium channel 0.0159 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0148 PF00186 Dihydrofolate reductase 0.0140 PF01652 Eukaryotic initiation factor 4E 0.0138 PF03098 Animal haem peroxidase 0.0136 PF02223 Thymidylate kinase 0.0135 PF00183 Hsp90 protein 0.0130 PF02142 MGS-like domain 0.0129 PF01370 NAD dependent epimerase/dehydratase family 0.0115 PF00227 Proteasome subunit 0.0111 PF03024 Folate receptor family 0.0106 PF00464 Serine hydroxymethyltransferase 0.0098 PF01061 ABC-2 type transporter 0.0097 PF01571 Aminomethyltransferase folate-binding domain 0.0097 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0097 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0097 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0095 PF00551 Formyl transferase 0.0088 PF00493 MCM2/3/5 family 0.0084 PF00171 Aldehyde dehydrogenase family 0.0084 PF02267 ADP-ribosyl cyclase 0.0083 PF00305 Lipoxygenase 0.0082 PF01575 MaoC like domain 0.0082 PF02036 SCP-2 sterol transfer family 0.0081 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0081 PF00025 ADP-ribosylation factor family 0.0071 PF08919 F-actin binding 0.0070 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0070 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0070 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0069 PF00273 Serum albumin family 0.0068 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0068 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0063 PF00091 Tubulin/FtsZ family, GTPase domain 0.0063 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0063 PF03953 Tubulin C-terminal domain 0.0063 PF00018 SH3 domain 0.0063 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0062 PF00017 SH2 domain 0.0057 PF02233 NAD(P), transhydrogenase beta subunit 0.0050 PF01180 Dihydroorotate dehydrogenase 0.0049 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0047 PF02059 Interleukin-3 0.0047 PF01731 Arylesterase 0.0045 PF02219 Methylenetetrahydrofolate reductase 0.0045 PF00822 PMP-22/EMP/MP20/Claudin family 0.0042 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0042 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0041 PF12491 Apolipoprotein B100 C terminal 0.0041 PF06448 Domain of Unknown Function (DUF1081), 0.0040 PF00999 Sodium/hydrogen exchanger family 0.0039 PF01023 S-100/ICaBP type calcium binding domain 0.0038 PF00028 Cadherin domain 0.0038 PF03360 Glycosyltransferase family 43 0.0037 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0037 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0035 PF09396 Thrombin light chain 0.0035 PF00405 Transferrin 0.0035 PF00005 ABC transporter 0.0035 PF03949 Malic enzyme, NAD binding domain 0.0035 PF00550 Phosphopantetheine attachment site 0.0035 PF00390 Malic enzyme, N-terminal domain 0.0033 PF00571 CBS domain 0.0031 PF00478 IMP dehydrogenase / GMP reductase domain 0.0028 PF00377 Prion/Doppel alpha-helical domain 0.0026 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0026 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0026 PF01347 Lipoprotein amino terminal region 0.0026 PF07884 Vitamin K epoxide reductase family 0.0025 PF00664 ABC transporter transmembrane region 0.0024 PF02769 AIR synthase related protein, C-terminal domain 0.0024 PF00656 Caspase domain 0.0024 PF00586 AIR synthase related protein, N-terminal domain 0.0024 PF02911 Formyl transferase, C-terminal domain 0.0023 PF00754 F5/8 type C domain 0.0023 PF00341 Platelet-derived growth factor (PDGF), 0.0023 PF10420 Cytokine interleukin-12p40 C-terminus 0.0022 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0022 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0019 PF01735 Lysophospholipase catalytic domain 0.0019 PF07722 Peptidase C26 0.0018 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0017 PF01404 Ephrin receptor ligand binding domain 0.0017 PF01227 GTP cyclohydrolase I 0.0017 PF00536 SAM domain (Sterile alpha motif), 0.0017 PF00654 Voltage gated chloride channel 0.0016 PF01187 Macrophage migration inhibitory factor (MIF), 0.0016 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0015 PF00079 Serpin (serine protease inhibitor), 0.0015 PF02394 Interleukin-1 propeptide 0.0015 PF03957 Jun-like transcription factor 0.0015 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0015 PF00340 Interleukin-1 / 18 0.0014 PF00291 Pyridoxal-phosphate dependent enzyme 0.0014 PF03171 2OG-Fe(II), oxygenase superfamily 0.0014 PF00264 Common central domain of tyrosinase 0.0013 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0013 PF00266 Aminotransferase class-V 0.0013 PF01477 PLAT/LH2 domain 0.0013 PF08403 Amino acid permease N-terminal 0.0012 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0012 PF00868 Transglutaminase family 0.0012 PF02260 FATC domain 0.0012 PF08771 Rapamycin binding domain 0.0012 PF00043 Glutathione S-transferase, C-terminal domain 0.0012 PF01841 Transglutaminase-like superfamily 0.0012 PF02259 FAT domain 0.0012 PF02798 Glutathione S-transferase, N-terminal domain 0.0012 PF02155 Glucocorticoid receptor 0.0012 PF00927 Transglutaminase family, C-terminal ig like domain 0.0012 PF00168 C2 domain 0.0011 PF00229 TNF(Tumour Necrosis Factor), family 0.0011 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0009 PF08659 KR domain 0.0009 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0009 PF00975 Thioesterase domain 0.0009 PF00085 Thioredoxin 0.0009 PF00155 Aminotransferase class I and II 0.0009 PF00108 Thiolase, N-terminal domain 0.0009 PF00989 PAS fold 0.0009 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0009 PF00698 Acyl transferase domain 0.0009 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0009 PF00040 Fibronectin type II domain 0.0009 PF02803 Thiolase, C-terminal domain 0.0009 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0009 PF00271 Helicase conserved C-terminal domain 0.0008 PF00191 Annexin 0.0008 PF02793 Hormone receptor domain 0.0008 PF01202 Shikimate kinase 0.0008 PF00002 7 transmembrane receptor (Secretin family), 0.0008 PF00170 bZIP transcription factor 0.0008 PF00176 SNF2 family N-terminal domain 0.0008 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0008 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0008 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0007 PF00027 Cyclic nucleotide-binding domain 0.0007 PF03062 MBOAT family 0.0007 PF01391 Collagen triple helix repeat (20 copies), 0.0007 PF00755 Choline/Carnitine o-acyltransferase 0.0007 PF01068 ATP dependent DNA ligase domain 0.0007 PF04679 ATP dependent DNA ligase C terminal region 0.0007 PF00058 Low-density lipoprotein receptor repeat class B 0.0006 PF02824 TGS domain 0.0006 PF00628 PHD-finger 0.0006 PF01753 MYND finger 0.0006 PF00609 Diacylglycerol kinase accessory domain 0.0006 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0006 PF02025 Interleukin 5 0.0006 PF02375 jmjN domain 0.0006 PF02373 JmjC domain 0.0006 PF00342 Phosphoglucose isomerase 0.0006 PF00860 Permease family 0.0006 PF01596 O-methyltransferase 0.0006 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0006 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0006 PF02928 C5HC2 zinc finger 0.0006 PF01388 ARID/BRIGHT DNA binding domain 0.0006 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0006 PF03034 Phosphatidyl serine synthase 0.0006 PF08429 PLU-1-like protein 0.0006 PF02180 Bcl-2 homology region 4 0.0006 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0006 PF00274 Fructose-bisphosphate aldolase class-I 0.0006 PF00781 Diacylglycerol kinase catalytic domain 0.0006 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0006 PF00094 von Willebrand factor type D domain 0.0006 PF08742 C8 domain 0.0005 PF01403 Sema domain 0.0005 PF00717 Peptidase S24-like 0.0005 PF03351 DOMON domain 0.0005 PF00057 Low-density lipoprotein receptor domain class A 0.0005 PF01833 IPT/TIG domain 0.0005 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0005 PF01437 Plexin repeat 0.0005 PF00343 Carbohydrate phosphorylase 0.0005 PF03476 MOSC N-terminal beta barrel domain 0.0005 PF03473 MOSC domain 0.0005 PF01425 Amidase 0.0005 PF01429 Methyl-CpG binding domain 0.0004 PF09193 Cholecystokinin A receptor, N-terminal 0.0004 PF02403 Seryl-tRNA synthetase N-terminal domain 0.0004 PF00270 DEAD/DEAH box helicase 0.0004 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0004 PF03623 Focal adhesion targeting region 0.0004 PF01130 CD36 family 0.0004 PF02898 Nitric oxide synthase, oxygenase domain 0.0004 PF00051 Kringle domain 0.0004 PF00969 Class II histocompatibility antigen, beta domain 0.0004 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0004 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0004 PF01916 Deoxyhypusine synthase 0.0004 PF07647 SAM domain (Sterile alpha motif), 0.0004 PF00676 Dehydrogenase E1 component 0.0004 PF11404 Potassium voltage-gated channel 0.0004 PF02666 Phosphatidylserine decarboxylase 0.0004 PF00246 Zinc carboxypeptidase 0.0004 PF00554 Rel homology domain (RHD), 0.0003 PF02347 Glycine cleavage system P-protein 0.0003 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0003 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.0003 PF01212 Beta-eliminating lyase 0.0003 PF00151 Lipase 0.0003 PF00373 FERM central domain 0.0003 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 0.0003 PF00020 TNFR/NGFR cysteine-rich region 0.0003 PF01168 Alanine racemase, N-terminal domain 0.0003 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0003 PF00294 pfkB family carbohydrate kinase 0.0003 PF00714 Interferon gamma 0.0003 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0003 PF07690 Major Facilitator Superfamily 0.0002 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0002 PF01462 Leucine rich repeat N-terminal domain 0.0002 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0002 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0002 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0002 PF00019 Transforming growth factor beta like domain 0.0002 PF00682 HMGL-like 0.0002 PF00688 TGF-beta propeptide 0.0002 PF00489 Interleukin-6/G-CSF/MGF family 0.0002 PF00202 Aminotransferase class-III 0.0001 PF02971 Formiminotransferase domain 0.0001 PF01067 Calpain large subunit, domain III 0.0001 PF00792 Phosphoinositide 3-kinase C2 0.0001 PF00794 PI3-kinase family, ras-binding domain 0.0001 PF04961 Formiminotransferase-cyclodeaminase 0.0001 PF02210 Laminin G domain 0.0001 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0001 PF06459 Ryanodine Receptor TM 4-6 0.0001 PF00074 Pancreatic ribonuclease 0.0001 PF00648 Calpain family cysteine protease 0.0001 PF07648 Kazal-type serine protease inhibitor domain 0.0001 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0001 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0001 PF00433 Protein kinase C terminal domain 0.0001 PF00432 Prenyltransferase and squalene oxidase repeat 0.0001 PF02758 PAAD/DAPIN/Pyrin domain 0.0001 PF04756 OST3 / OST6 family 0.0001 PF02026 RyR domain 0.0001 PF02815 MIR domain 0.0001 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0001 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0001 PF08454 RyR and IP3R Homology associated 0.0001 PF00024 PAN domain 0.0001 PF01365 RIH domain 0.0001 PF00619 Caspase recruitment domain 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0001 PF00622 SPRY domain 0.0001 PF02460 Patched family 0.0001 PF08709 Inositol 1,4,5-trisphosphate/ryanodine receptor 0.0001 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0001 PF00787 PX domain 0.0001 PF00354 Pentaxin family 0.0001 PF03129 Anticodon binding domain SUB533 S-C:C-[#1] 0.2583 PF00194 Eukaryotic-type carbonic anhydrase 0.0773 PF08403 Amino acid permease N-terminal 0.0664 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0664 PF02254 TrkA-N domain 0.0384 PF00324 Amino acid permease 0.0275 PF00689 Cation transporting ATPase, C-terminus 0.0275 PF00690 Cation transporter/ATPase, N-terminus 0.0269 PF01007 Inward rectifier potassium channel 0.0244 PF00122 E1-E2 ATPase 0.0215 PF00702 haloacid dehalogenase-like hydrolase 0.0192 PF01471 Putative peptidoglycan binding domain 0.0192 PF00045 Hemopexin 0.0178 PF00413 Matrixin 0.0144 PF09396 Thrombin light chain 0.0134 PF00520 Ion transport protein 0.0131 PF00102 Protein-tyrosine phosphatase 0.0107 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0106 PF02146 Sir2 family 0.0093 PF00664 ABC transporter transmembrane region 0.0088 PF00005 ABC transporter 0.0086 PF03098 Animal haem peroxidase 0.0084 PF01916 Deoxyhypusine synthase 0.0082 PF00167 Fibroblast growth factor 0.0074 PF02038 ATP1G1/PLM/MAT8 family 0.0071 PF01590 GAF domain 0.0065 PF10420 Cytokine interleukin-12p40 C-terminus 0.0064 PF02803 Thiolase, C-terminal domain 0.0064 PF00108 Thiolase, N-terminal domain 0.0062 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0062 PF00040 Fibronectin type II domain 0.0057 PF00089 Trypsin 0.0055 PF00027 Cyclic nucleotide-binding domain 0.0051 PF00989 PAS fold 0.0049 PF00051 Kringle domain 0.0042 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0038 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0036 PF00043 Glutathione S-transferase, C-terminal domain 0.0035 PF02798 Glutathione S-transferase, N-terminal domain 0.0034 PF00069 Protein kinase domain 0.0033 PF00112 Papain family cysteine protease 0.0033 PF08983 Domain of unknown function (DUF1856), 0.0032 PF02185 Hr1 repeat 0.0032 PF08912 Rho Binding 0.0031 PF08725 Integrin beta cytoplasmic domain 0.0031 PF08702 Fibrinogen alpha/beta chain family 0.0031 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0031 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0030 PF02060 Slow voltage-gated potassium channel 0.0030 PF08441 Integrin alpha 0.0028 PF08466 Inward rectifier potassium channel N-terminal 0.0028 PF00230 Major intrinsic protein 0.0028 PF01530 Zinc finger, C2HC type 0.0028 PF00188 Cysteine-rich secretory protein family 0.0028 PF02820 mbt repeat 0.0027 PF07885 Ion channel 0.0026 PF07965 Integrin beta tail domain 0.0026 PF00362 Integrin, beta chain 0.0025 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0024 PF00489 Interleukin-6/G-CSF/MGF family 0.0024 PF00186 Dihydrofolate reductase 0.0023 PF00273 Serum albumin family 0.0021 PF00578 AhpC/TSA family 0.0021 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0021 PF08447 PAS fold 0.0020 PF00581 Rhodanese-like domain 0.0020 PF06617 M-phase inducer phosphatase 0.0020 PF07966 A1 Propeptide 0.0018 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0018 PF03489 Saposin-like type B, region 2 0.0018 PF01323 DSBA-like thioredoxin domain 0.0017 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0017 PF03520 KCNQ voltage-gated potassium channel 0.0017 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0015 PF00357 Integrin alpha cytoplasmic region 0.0015 PF00287 Sodium / potassium ATPase beta chain 0.0014 PF11857 Domain of unknown function (DUF3377), 0.0014 PF01030 Receptor L domain 0.0014 PF01234 NNMT/PNMT/TEMT family 0.0014 PF00757 Furin-like cysteine rich region 0.0013 PF00026 Eukaryotic aspartyl protease 0.0013 PF00092 von Willebrand factor type A domain 0.0012 PF00822 PMP-22/EMP/MP20/Claudin family 0.0012 PF01068 ATP dependent DNA ligase domain 0.0012 PF04679 ATP dependent DNA ligase C terminal region 0.0012 PF12160 Fibrinogen alpha C domain 0.0011 PF00625 Guanylate kinase 0.0010 PF12497 Estrogen receptor beta 0.0010 PF00341 Platelet-derived growth factor (PDGF), 0.0009 PF08399 VWA N-terminal 0.0009 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0009 PF08833 Axin beta-catenin binding domain 0.0009 PF02793 Hormone receptor domain 0.0009 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0009 PF00002 7 transmembrane receptor (Secretin family), 0.0009 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0009 PF00024 PAN domain 0.0009 PF00778 DIX domain 0.0009 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0009 PF02743 Cache domain 0.0009 PF04055 Radical SAM superfamily 0.0008 PF09193 Cholecystokinin A receptor, N-terminal 0.0008 PF00020 TNFR/NGFR cysteine-rich region 0.0007 PF00337 Galactoside-binding lectin 0.0006 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0006 PF00084 Sushi domain (SCR repeat), 0.0006 PF01731 Arylesterase 0.0006 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0006 PF00265 Thymidine kinase 0.0006 PF01369 Sec7 domain 0.0006 PF00058 Low-density lipoprotein receptor repeat class B 0.0005 PF00850 Histone deacetylase domain 0.0005 PF07645 Calcium-binding EGF domain 0.0005 PF00183 Hsp90 protein 0.0005 PF00656 Caspase domain 0.0005 PF00431 CUB domain 0.0004 PF00059 Lectin C-type domain 0.0004 PF03099 Biotin/lipoate A/B protein ligase family 0.0004 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF01462 Leucine rich repeat N-terminal domain 0.0003 PF00615 Regulator of G protein signaling domain 0.0003 PF00474 Sodium:solute symporter family 0.0002 PF00433 Protein kinase C terminal domain 0.0001 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region SUB330 C(~Br)(~H) 0.2580 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.2571 PF00146 NADH dehydrogenase 0.1703 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1703 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1597 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1597 PF02254 TrkA-N domain 0.1290 PF00689 Cation transporting ATPase, C-terminus 0.1290 PF00690 Cation transporter/ATPase, N-terminus 0.1155 PF03530 Calcium-activated SK potassium channel 0.1155 PF02888 Calmodulin binding domain 0.1152 PF00631 GGL domain 0.1152 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.1139 PF00122 E1-E2 ATPase 0.1016 PF00702 haloacid dehalogenase-like hydrolase 0.0939 PF00191 Annexin 0.0938 PF02214 K+ channel tetramerisation domain 0.0920 PF00194 Eukaryotic-type carbonic anhydrase 0.0788 PF01007 Inward rectifier potassium channel 0.0766 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0549 PF00520 Ion transport protein 0.0544 PF00273 Serum albumin family 0.0541 PF12497 Estrogen receptor beta 0.0511 PF07885 Ion channel 0.0451 PF00060 Ligand-gated ion channel 0.0417 PF08403 Amino acid permease N-terminal 0.0394 PF02155 Glucocorticoid receptor 0.0355 PF02159 Oestrogen receptor 0.0321 PF01094 Receptor family ligand binding region 0.0227 PF08377 MAP2/Tau projection domain 0.0227 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0219 PF00079 Serpin (serine protease inhibitor), 0.0211 PF06464 DMAP1-binding Domain 0.0211 PF02008 CXXC zinc finger domain 0.0211 PF01426 BAH domain 0.0210 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0162 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0135 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0123 PF00324 Amino acid permease 0.0111 PF00145 C-5 cytosine-specific DNA methylase 0.0094 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0088 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0085 PF00462 Glutaredoxin 0.0076 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0055 PF00576 HIUase/Transthyretin family 0.0052 PF00102 Protein-tyrosine phosphatase 0.0045 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0035 PF01735 Lysophospholipase catalytic domain 0.0033 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0031 PF00105 Zinc finger, C4 type (two domains), 0.0030 PF03073 TspO/MBR family 0.0028 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0028 PF00204 DNA gyrase B 0.0028 PF08070 DTHCT (NUC029), region 0.0028 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0025 PF02166 Androgen receptor 0.0023 PF00287 Sodium / potassium ATPase beta chain 0.0021 PF03953 Tubulin C-terminal domain 0.0021 PF00091 Tubulin/FtsZ family, GTPase domain 0.0009 PF00303 Thymidylate synthase 0.0006 PF00017 SH2 domain 0.0006 PF00175 Oxidoreductase NAD-binding domain 0.0006 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0006 PF00667 FAD binding domain 0.0006 PF02898 Nitric oxide synthase, oxygenase domain 0.0006 PF00230 Major intrinsic protein 0.0006 PF00258 Flavodoxin 0.0005 PF00018 SH3 domain 0.0004 PF00962 Adenosine/AMP deaminase 0.0004 PF04679 ATP dependent DNA ligase C terminal region 0.0004 PF01068 ATP dependent DNA ligase domain 0.0004 PF01122 Eukaryotic cobalamin-binding protein 0.0004 PF08919 F-actin binding 0.0004 PF00478 IMP dehydrogenase / GMP reductase domain 0.0004 PF01770 Reduced folate carrier 0.0003 PF00156 Phosphoribosyl transferase domain 0.0003 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0003 PF01923 Cobalamin adenosyltransferase 0.0003 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0003 PF10397 Adenylosuccinate lyase C-terminus 0.0003 PF01642 Methylmalonyl-CoA mutase 0.0003 PF03308 ArgK protein 0.0003 PF01404 Ephrin receptor ligand binding domain 0.0003 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0003 PF00536 SAM domain (Sterile alpha motif), 0.0003 PF00854 POT family 0.0002 PF01687 Riboflavin kinase 0.0002 PF02864 STAT protein, DNA binding domain 0.0002 PF02865 STAT protein, protein interaction domain 0.0002 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF00794 PI3-kinase family, ras-binding domain 0.0002 PF02310 B12 binding domain 0.0002 PF00958 GMP synthase C terminal domain 0.0002 PF00206 Lyase 0.0002 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0002 PF01017 STAT protein, all-alpha domain 0.0001 PF12126 Protein of unknown function (DUF3583), 0.0001 PF00779 BTK motif 0.0001 PF01180 Dihydroorotate dehydrogenase 0.0001 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0001 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0001 PF00625 Guanylate kinase 0.0001 PF00489 Interleukin-6/G-CSF/MGF family 0.0001 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0001 PF00459 Inositol monophosphatase family 0.0001 PF08063 PADR1 (NUC008), domain 0.0001 PF00970 Oxidoreductase FAD-binding domain 0.0001 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0001 PF02607 B12 binding domain 0.0001 PF00245 Alkaline phosphatase 0.0001 PF00069 Protein kinase domain 0.0001 PF02196 Raf-like Ras-binding domain 0.0001 PF00809 Pterin binding enzyme 0.0001 PF02828 L27 domain 0.0001 PF03453 MoeA N-terminal region (domain I and II), 0.0001 PF03454 MoeA C-terminal region (domain IV), 0.0001 PF00571 CBS domain 0.0001 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0001 PF00654 Voltage gated chloride channel 0.0001 PF00405 Transferrin 0.0001 PF00994 Probable molybdopterin binding domain 0.0001 PF00709 Adenylosuccinate synthetase 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0001 PF00431 CUB domain 0.0001 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0001 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0001 PF01437 Plexin repeat 0.0001 PF07970 Endoplasmic reticulum vesicle transporter 0.0001 PF00134 Cyclin, N-terminal domain 0.0001 PF05406 WGR domain 0.0001 PF01403 Sema domain 0.0001 PF02441 Flavoprotein 0.0001 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0001 PF00514 Armadillo/beta-catenin-like repeat 0.0001 PF00117 Glutamine amidotransferase class-I 0.0001 PF00533 BRCA1 C Terminus (BRCT), domain 0.0001 PF02984 Cyclin, C-terminal domain 0.0001 PF01835 MG2 domain 0.0001 PF01833 IPT/TIG domain SUB585 C:C-C=C-C 0.2569 PF00001 7 transmembrane receptor (rhodopsin family), 0.1199 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0863 PF00209 Sodium:neurotransmitter symporter family 0.0790 PF03098 Animal haem peroxidase 0.0638 PF08070 DTHCT (NUC029), region 0.0638 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0638 PF00204 DNA gyrase B 0.0577 PF06512 Sodium ion transport-associated 0.0575 PF00194 Eukaryotic-type carbonic anhydrase 0.0504 PF00520 Ion transport protein 0.0489 PF03073 TspO/MBR family 0.0299 PF00989 PAS fold 0.0250 PF09396 Thrombin light chain 0.0250 PF00102 Protein-tyrosine phosphatase 0.0247 PF00027 Cyclic nucleotide-binding domain 0.0206 PF00186 Dihydrofolate reductase 0.0192 PF00091 Tubulin/FtsZ family, GTPase domain 0.0192 PF03953 Tubulin C-terminal domain 0.0186 PF00576 HIUase/Transthyretin family 0.0185 PF01593 Flavin containing amine oxidoreductase 0.0160 PF08403 Amino acid permease N-terminal 0.0158 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0143 PF01007 Inward rectifier potassium channel 0.0105 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0097 PF00005 ABC transporter 0.0069 PF02254 TrkA-N domain 0.0069 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0062 PF02159 Oestrogen receptor 0.0061 PF05649 Peptidase family M13 0.0061 PF07884 Vitamin K epoxide reductase family 0.0061 PF01431 Peptidase family M13 0.0052 PF00664 ABC transporter transmembrane region 0.0049 PF01401 Angiotensin-converting enzyme 0.0041 PF00017 SH2 domain 0.0025 PF00069 Protein kinase domain 0.0025 PF12497 Estrogen receptor beta 0.0025 PF00822 PMP-22/EMP/MP20/Claudin family 0.0019 PF08983 Domain of unknown function (DUF1856), 0.0019 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0017 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0013 PF00018 SH3 domain 0.0011 PF00042 Globin 0.0002 PF00067 Cytochrome P450 SUB678 C-C=C-C:C 0.2569 PF00001 7 transmembrane receptor (rhodopsin family), 0.1199 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0863 PF00209 Sodium:neurotransmitter symporter family 0.0790 PF03098 Animal haem peroxidase 0.0638 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0638 PF08070 DTHCT (NUC029), region 0.0638 PF00204 DNA gyrase B 0.0577 PF06512 Sodium ion transport-associated 0.0575 PF00194 Eukaryotic-type carbonic anhydrase 0.0504 PF00520 Ion transport protein 0.0489 PF03073 TspO/MBR family 0.0299 PF00989 PAS fold 0.0250 PF00102 Protein-tyrosine phosphatase 0.0250 PF09396 Thrombin light chain 0.0247 PF00027 Cyclic nucleotide-binding domain 0.0206 PF00186 Dihydrofolate reductase 0.0192 PF03953 Tubulin C-terminal domain 0.0192 PF00091 Tubulin/FtsZ family, GTPase domain 0.0186 PF00576 HIUase/Transthyretin family 0.0185 PF01593 Flavin containing amine oxidoreductase 0.0160 PF08403 Amino acid permease N-terminal 0.0158 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0143 PF01007 Inward rectifier potassium channel 0.0105 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0097 PF00005 ABC transporter 0.0069 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0069 PF02254 TrkA-N domain 0.0062 PF02159 Oestrogen receptor 0.0061 PF07884 Vitamin K epoxide reductase family 0.0061 PF05649 Peptidase family M13 0.0061 PF01431 Peptidase family M13 0.0052 PF00664 ABC transporter transmembrane region 0.0049 PF01401 Angiotensin-converting enzyme 0.0041 PF00017 SH2 domain 0.0025 PF00822 PMP-22/EMP/MP20/Claudin family 0.0025 PF12497 Estrogen receptor beta 0.0025 PF00069 Protein kinase domain 0.0019 PF08983 Domain of unknown function (DUF1856), 0.0019 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0017 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0013 PF00018 SH3 domain 0.0011 PF00042 Globin 0.0002 PF00067 Cytochrome P450 SUB442 C(-C)(=C) 0.2562 PF00001 7 transmembrane receptor (rhodopsin family), 0.1091 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.1056 PF03098 Animal haem peroxidase 0.0954 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0952 PF00105 Zinc finger, C4 type (two domains), 0.0901 PF02159 Oestrogen receptor 0.0659 PF00209 Sodium:neurotransmitter symporter family 0.0514 PF06512 Sodium ion transport-associated 0.0345 PF03073 TspO/MBR family 0.0288 PF09396 Thrombin light chain 0.0243 PF00005 ABC transporter 0.0238 PF00191 Annexin 0.0236 PF00989 PAS fold 0.0200 PF00067 Cytochrome P450 0.0198 PF00520 Ion transport protein 0.0196 PF00664 ABC transporter transmembrane region 0.0189 PF00027 Cyclic nucleotide-binding domain 0.0139 PF02155 Glucocorticoid receptor 0.0113 PF01593 Flavin containing amine oxidoreductase 0.0112 PF02161 Progesterone receptor 0.0081 PF00186 Dihydrofolate reductase 0.0076 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0058 PF01007 Inward rectifier potassium channel 0.0034 PF01735 Lysophospholipase catalytic domain 0.0030 PF11825 Protein of unknown function (DUF3345), 0.0025 PF00017 SH2 domain 0.0020 PF12497 Estrogen receptor beta SUB133 >= 1 saturated or aromatic heteroatom-containing ring size 4 0.2490 PF00273 Serum albumin family 0.2034 PF12179 I-kappa-kinase-beta NEMO binding domain 0.1650 PF08534 Redoxin 0.0894 PF00854 POT family 0.0669 PF09396 Thrombin light chain 0.0412 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0412 PF02180 Bcl-2 homology region 4 0.0390 PF00069 Protein kinase domain 0.0375 PF12126 Protein of unknown function (DUF3583), 0.0375 PF07970 Endoplasmic reticulum vesicle transporter 0.0375 PF02984 Cyclin, C-terminal domain 0.0375 PF00134 Cyclin, N-terminal domain 0.0365 PF03957 Jun-like transcription factor 0.0365 PF00489 Interleukin-6/G-CSF/MGF family 0.0338 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0338 PF08702 Fibrinogen alpha/beta chain family 0.0312 PF02460 Patched family 0.0308 PF01731 Arylesterase 0.0307 PF03062 MBOAT family 0.0289 PF00151 Lipase 0.0255 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0246 PF00170 bZIP transcription factor 0.0243 PF00051 Kringle domain 0.0203 PF05649 Peptidase family M13 0.0203 PF01431 Peptidase family M13 0.0203 PF00643 B-box zinc finger 0.0203 PF01401 Angiotensin-converting enzyme 0.0200 PF08659 KR domain 0.0200 PF00975 Thioesterase domain 0.0200 PF00698 Acyl transferase domain 0.0200 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0200 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0193 PF12160 Fibrinogen alpha C domain 0.0189 PF00690 Cation transporter/ATPase, N-terminus 0.0189 PF00689 Cation transporting ATPase, C-terminus 0.0173 PF01477 PLAT/LH2 domain 0.0167 PF00122 E1-E2 ATPase 0.0166 PF01433 Peptidase family M1 0.0150 PF00167 Fibroblast growth factor 0.0147 PF00702 haloacid dehalogenase-like hydrolase 0.0142 PF00664 ABC transporter transmembrane region 0.0133 PF00576 HIUase/Transthyretin family 0.0132 PF00433 Protein kinase C terminal domain 0.0130 PF01459 Eukaryotic porin 0.0129 PF00089 Trypsin 0.0117 PF00059 Lectin C-type domain 0.0114 PF00079 Serpin (serine protease inhibitor), 0.0111 PF00550 Phosphopantetheine attachment site 0.0111 PF00343 Carbohydrate phosphorylase 0.0111 PF00005 ABC transporter 0.0092 PF03953 Tubulin C-terminal domain 0.0092 PF00091 Tubulin/FtsZ family, GTPase domain 0.0086 PF00169 PH domain 0.0080 PF07645 Calcium-binding EGF domain 0.0078 PF02423 Ornithine cyclodeaminase/mu-crystallin family 0.0076 PF00405 Transferrin 0.0059 PF00107 Zinc-binding dehydrogenase 0.0058 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0057 PF02146 Sir2 family 0.0047 PF00024 PAN domain 0.0039 PF00146 NADH dehydrogenase 0.0039 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0038 PF01161 Phosphatidylethanolamine-binding protein 0.0034 PF00459 Inositol monophosphatase family 0.0027 PF00581 Rhodanese-like domain 0.0027 PF06617 M-phase inducer phosphatase 0.0027 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0026 PF00194 Eukaryotic-type carbonic anhydrase 0.0025 PF02806 Alpha amylase, C-terminal all-beta domain 0.0023 PF03160 Calx-beta domain 0.0021 PF00324 Amino acid permease 0.0020 PF00625 Guanylate kinase 0.0020 PF00128 Alpha amylase, catalytic domain 0.0020 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0020 PF02214 K+ channel tetramerisation domain 0.0018 PF00514 Armadillo/beta-catenin-like repeat 0.0015 PF00248 Aldo/keto reductase family 0.0015 PF02793 Hormone receptor domain 0.0015 PF00084 Sushi domain (SCR repeat), 0.0015 PF00002 7 transmembrane receptor (Secretin family), 0.0014 PF03454 MoeA C-terminal region (domain IV), 0.0014 PF02828 L27 domain 0.0014 PF03453 MoeA N-terminal region (domain I and II), 0.0014 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0014 PF00994 Probable molybdopterin binding domain 0.0014 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0014 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0014 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0014 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0014 PF01369 Sec7 domain 0.0013 PF00362 Integrin, beta chain 0.0013 PF01055 Glycosyl hydrolases family 31 0.0013 PF07965 Integrin beta tail domain 0.0013 PF00088 Trefoil (P-type), domain 0.0013 PF00822 PMP-22/EMP/MP20/Claudin family 0.0013 PF08403 Amino acid permease N-terminal 0.0012 PF09193 Cholecystokinin A receptor, N-terminal 0.0012 PF04679 ATP dependent DNA ligase C terminal region 0.0012 PF01068 ATP dependent DNA ligase domain 0.0011 PF00317 Ribonucleotide reductase, all-alpha domain 0.0011 PF03477 ATP cone domain 0.0011 PF00211 Adenylate and Guanylate cyclase catalytic domain 0.0011 PF02867 Ribonucleotide reductase, barrel domain 0.0010 PF00188 Cysteine-rich secretory protein family 0.0010 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0010 PF00578 AhpC/TSA family 0.0010 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0010 PF01370 NAD dependent epimerase/dehydratase family 0.0009 PF08240 Alcohol dehydrogenase GroES-like domain 0.0009 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0009 PF01323 DSBA-like thioredoxin domain 0.0009 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0009 PF03414 Glycosyltransferase family 6 0.0008 PF02260 FATC domain 0.0008 PF08771 Rapamycin binding domain 0.0008 PF03949 Malic enzyme, NAD binding domain 0.0008 PF00041 Fibronectin type III domain 0.0008 PF00390 Malic enzyme, N-terminal domain 0.0008 PF02259 FAT domain 0.0007 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0007 PF07653 Variant SH3 domain 0.0007 PF00439 Bromodomain 0.0007 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0007 PF01835 MG2 domain 0.0007 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0007 PF02743 Cache domain 0.0007 PF07678 A-macroglobulin complement component 0.0007 PF07677 A-macroglobulin receptor 0.0007 PF03489 Saposin-like type B, region 2 0.0007 PF08399 VWA N-terminal 0.0007 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0007 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0006 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0006 PF00462 Glutaredoxin 0.0006 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0006 PF08763 Voltage gated calcium channel IQ domain 0.0006 PF00328 Histidine acid phosphatase 0.0006 PF03073 TspO/MBR family 0.0005 PF03770 Inositol polyphosphate kinase 0.0005 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0005 PF01652 Eukaryotic initiation factor 4E 0.0004 PF02233 NAD(P), transhydrogenase beta subunit 0.0004 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0004 PF03098 Animal haem peroxidase 0.0004 PF02267 ADP-ribosyl cyclase 0.0004 PF00595 PDZ domain (Also known as DHR or GLGF), 0.0004 PF08983 Domain of unknown function (DUF1856), 0.0004 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF02803 Thiolase, C-terminal domain 0.0003 PF00631 GGL domain 0.0003 PF00108 Thiolase, N-terminal domain 0.0003 PF00106 short chain dehydrogenase 0.0003 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0003 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0003 PF05193 Peptidase M16 inactive domain 0.0003 PF00153 Mitochondrial carrier protein 0.0003 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0003 PF00431 CUB domain 0.0003 PF00675 Insulinase (Peptidase family M16), 0.0003 PF00821 Phosphoenolpyruvate carboxykinase 0.0003 PF00378 Enoyl-CoA hydratase/isomerase family 0.0002 PF00858 Amiloride-sensitive sodium channel 0.0002 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0002 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0002 PF09127 Leukotriene A4 hydrolase, C-terminal 0.0002 PF00406 Adenylate kinase 0.0002 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0002 PF03360 Glycosyltransferase family 43 0.0002 PF01122 Eukaryotic cobalamin-binding protein 0.0002 PF08674 Acetylcholinesterase tetramerisation domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF00171 Aldehyde dehydrogenase family 0.0002 PF00779 BTK motif 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF02254 TrkA-N domain 0.0001 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0001 PF02223 Thymidylate kinase 0.0001 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0001 PF00303 Thymidylate synthase 0.0001 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0001 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0001 PF03530 Calcium-activated SK potassium channel 0.0001 PF02888 Calmodulin binding domain 0.0001 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment SUB36 >= 4 S 0.2487 PF08702 Fibrinogen alpha/beta chain family 0.2487 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.1557 PF00273 Serum albumin family 0.1420 PF12160 Fibrinogen alpha C domain 0.1417 PF09396 Thrombin light chain 0.1079 PF00167 Fibroblast growth factor 0.0953 PF01459 Eukaryotic porin 0.0840 PF00079 Serpin (serine protease inhibitor), 0.0831 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0710 PF00051 Kringle domain 0.0688 PF00089 Trypsin 0.0425 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0420 PF02146 Sir2 family 0.0349 PF00024 PAN domain 0.0341 PF00405 Transferrin 0.0217 PF00854 POT family 0.0184 PF02806 Alpha amylase, C-terminal all-beta domain 0.0176 PF00690 Cation transporter/ATPase, N-terminus 0.0176 PF00689 Cation transporting ATPase, C-terminus 0.0168 PF00059 Lectin C-type domain 0.0156 PF00122 E1-E2 ATPase 0.0150 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0145 PF00128 Alpha amylase, catalytic domain 0.0120 PF00702 haloacid dehalogenase-like hydrolase 0.0110 PF00084 Sushi domain (SCR repeat), 0.0108 PF02793 Hormone receptor domain 0.0108 PF00002 7 transmembrane receptor (Secretin family), 0.0105 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0100 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0100 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0100 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0100 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0094 PF01055 Glycosyl hydrolases family 31 0.0094 PF00088 Trefoil (P-type), domain 0.0091 PF09193 Cholecystokinin A receptor, N-terminal 0.0087 PF04679 ATP dependent DNA ligase C terminal region 0.0087 PF01068 ATP dependent DNA ligase domain 0.0074 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0072 PF00188 Cysteine-rich secretory protein family 0.0072 PF01370 NAD dependent epimerase/dehydratase family 0.0072 PF00578 AhpC/TSA family 0.0072 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0068 PF01731 Arylesterase 0.0068 PF01323 DSBA-like thioredoxin domain 0.0065 PF03414 Glycosyltransferase family 6 0.0063 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0063 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0061 PF02260 FATC domain 0.0061 PF02259 FAT domain 0.0061 PF08771 Rapamycin binding domain 0.0057 PF02180 Bcl-2 homology region 4 0.0057 PF02460 Patched family 0.0057 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0054 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0053 PF03489 Saposin-like type B, region 2 0.0052 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0050 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0050 PF01835 MG2 domain 0.0050 PF07678 A-macroglobulin complement component 0.0050 PF07677 A-macroglobulin receptor 0.0049 PF03062 MBOAT family 0.0048 PF00439 Bromodomain 0.0048 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0046 PF00581 Rhodanese-like domain 0.0046 PF06617 M-phase inducer phosphatase 0.0041 PF03073 TspO/MBR family 0.0040 PF03770 Inositol polyphosphate kinase 0.0039 PF01652 Eukaryotic initiation factor 4E 0.0039 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0037 PF00169 PH domain 0.0033 PF00091 Tubulin/FtsZ family, GTPase domain 0.0033 PF03953 Tubulin C-terminal domain 0.0031 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0031 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0031 PF02233 NAD(P), transhydrogenase beta subunit 0.0029 PF02267 ADP-ribosyl cyclase 0.0028 PF08983 Domain of unknown function (DUF1856), 0.0025 PF00248 Aldo/keto reductase family 0.0024 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0023 PF00151 Lipase 0.0022 PF00675 Insulinase (Peptidase family M16), 0.0022 PF00378 Enoyl-CoA hydratase/isomerase family 0.0022 PF05193 Peptidase M16 inactive domain 0.0021 PF00106 short chain dehydrogenase 0.0021 PF00108 Thiolase, N-terminal domain 0.0021 PF02803 Thiolase, C-terminal domain 0.0021 PF00431 CUB domain 0.0018 PF00171 Aldehyde dehydrogenase family 0.0017 PF03360 Glycosyltransferase family 43 0.0016 PF07645 Calcium-binding EGF domain 0.0016 PF00406 Adenylate kinase 0.0015 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0014 PF00779 BTK motif 0.0014 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0014 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0012 PF01122 Eukaryotic cobalamin-binding protein 0.0011 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0011 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0010 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0009 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0009 PF01433 Peptidase family M1 0.0009 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0008 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0008 PF02223 Thymidylate kinase 0.0003 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF00975 Thioesterase domain 0.0002 PF01923 Cobalamin adenosyltransferase 0.0002 PF01852 START domain 0.0002 PF01642 Methylmalonyl-CoA mutase 0.0002 PF00698 Acyl transferase domain 0.0002 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0002 PF08659 KR domain 0.0002 PF03308 ArgK protein 0.0002 PF00583 Acetyltransferase (GNAT), family 0.0002 PF02801 Beta-ketoacyl synthase, C-terminal domain SUB592 Cl-C-C-C-C 0.2473 PF03073 TspO/MBR family 0.1734 PF00194 Eukaryotic-type carbonic anhydrase 0.1303 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1303 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1240 PF08403 Amino acid permease N-terminal 0.1065 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1065 PF02254 TrkA-N domain 0.0554 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0479 PF00209 Sodium:neurotransmitter symporter family 0.0451 PF00001 7 transmembrane receptor (rhodopsin family), 0.0424 PF00324 Amino acid permease 0.0387 PF00520 Ion transport protein 0.0265 PF00018 SH3 domain 0.0257 PF00069 Protein kinase domain 0.0239 PF01030 Receptor L domain 0.0239 PF00757 Furin-like cysteine rich region 0.0235 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0231 PF03098 Animal haem peroxidase 0.0223 PF00690 Cation transporter/ATPase, N-terminus 0.0223 PF00689 Cation transporting ATPase, C-terminus 0.0205 PF00017 SH2 domain 0.0201 PF00186 Dihydrofolate reductase 0.0183 PF00305 Lipoxygenase 0.0183 PF00122 E1-E2 ATPase 0.0166 PF01477 PLAT/LH2 domain 0.0161 PF00664 ABC transporter transmembrane region 0.0156 PF06512 Sodium ion transport-associated 0.0139 PF08919 F-actin binding 0.0139 PF00005 ABC transporter 0.0132 PF00989 PAS fold 0.0131 PF00702 haloacid dehalogenase-like hydrolase 0.0128 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0124 PF01007 Inward rectifier potassium channel 0.0119 PF00067 Cytochrome P450 0.0110 PF02196 Raf-like Ras-binding domain 0.0108 PF02060 Slow voltage-gated potassium channel 0.0108 PF01734 Patatin-like phospholipase 0.0108 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0108 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0108 PF02038 ATP1G1/PLM/MAT8 family 0.0108 PF03630 Fumble 0.0100 PF00243 Nerve growth factor family 0.0100 PF00612 IQ calmodulin-binding motif 0.0083 PF00027 Cyclic nucleotide-binding domain 0.0082 PF00536 SAM domain (Sterile alpha motif), 0.0082 PF01404 Ephrin receptor ligand binding domain 0.0071 PF08063 PADR1 (NUC008), domain 0.0071 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0071 PF03530 Calcium-activated SK potassium channel 0.0071 PF02888 Calmodulin binding domain 0.0071 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0071 PF00533 BRCA1 C Terminus (BRCT), domain 0.0071 PF05406 WGR domain 0.0054 PF00042 Globin 0.0048 PF00343 Carbohydrate phosphorylase 0.0039 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0039 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0039 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0039 PF01582 TIR domain 0.0039 PF05193 Peptidase M16 inactive domain 0.0039 PF00675 Insulinase (Peptidase family M16), 0.0037 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0034 PF02864 STAT protein, DNA binding domain 0.0034 PF01017 STAT protein, all-alpha domain 0.0034 PF02865 STAT protein, protein interaction domain 0.0025 PF03520 KCNQ voltage-gated potassium channel 0.0015 PF00976 Corticotropin ACTH domain 0.0015 PF08384 Pro-opiomelanocortin, N-terminal region 0.0015 PF08035 Opioids neuropeptide 0.0013 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0012 PF01094 Receptor family ligand binding region 0.0012 PF00576 HIUase/Transthyretin family 0.0009 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0005 PF00060 Ligand-gated ion channel 0.0005 PF00111 2Fe-2S iron-sulfur cluster binding domain SUB661 C-C=C-C-C 0.2458 PF00001 7 transmembrane receptor (rhodopsin family), 0.1129 PF02159 Oestrogen receptor 0.1049 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.1043 PF00105 Zinc finger, C4 type (two domains), 0.1036 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0996 PF03098 Animal haem peroxidase 0.0698 PF00209 Sodium:neurotransmitter symporter family 0.0481 PF06512 Sodium ion transport-associated 0.0477 PF00204 DNA gyrase B 0.0477 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0477 PF08070 DTHCT (NUC029), region 0.0378 PF00520 Ion transport protein 0.0292 PF03073 TspO/MBR family 0.0291 PF00191 Annexin 0.0278 PF02161 Progesterone receptor 0.0239 PF00194 Eukaryotic-type carbonic anhydrase 0.0226 PF00989 PAS fold 0.0216 PF09396 Thrombin light chain 0.0211 PF02155 Glucocorticoid receptor 0.0182 PF00067 Cytochrome P450 0.0182 PF00027 Cyclic nucleotide-binding domain 0.0134 PF01593 Flavin containing amine oxidoreductase 0.0094 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0082 PF00186 Dihydrofolate reductase 0.0078 PF01735 Lysophospholipase catalytic domain 0.0069 PF12497 Estrogen receptor beta 0.0068 PF01007 Inward rectifier potassium channel 0.0065 PF00305 Lipoxygenase 0.0052 PF00005 ABC transporter 0.0050 PF08403 Amino acid permease N-terminal 0.0038 PF00102 Protein-tyrosine phosphatase 0.0038 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0034 PF00576 HIUase/Transthyretin family 0.0023 PF00273 Serum albumin family 0.0021 PF00664 ABC transporter transmembrane region 0.0007 PF00091 Tubulin/FtsZ family, GTPase domain 0.0007 PF03953 Tubulin C-terminal domain 0.0006 PF07884 Vitamin K epoxide reductase family 0.0001 PF05649 Peptidase family M13 0.0001 PF01431 Peptidase family M13 SUB418 C#C 0.2458 PF02159 Oestrogen receptor 0.1822 PF02161 Progesterone receptor 0.1457 PF00105 Zinc finger, C4 type (two domains), 0.1438 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0439 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0439 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0400 PF01593 Flavin containing amine oxidoreductase 0.0399 PF02155 Glucocorticoid receptor 0.0253 PF00191 Annexin 0.0235 PF00273 Serum albumin family 0.0164 PF00039 Fibronectin type I domain 0.0159 PF03098 Animal haem peroxidase 0.0156 PF02166 Androgen receptor 0.0136 PF08491 Squalene epoxidase 0.0135 PF00079 Serpin (serine protease inhibitor), 0.0125 PF00576 HIUase/Transthyretin family 0.0118 PF01735 Lysophospholipase catalytic domain 0.0116 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0116 PF02180 Bcl-2 homology region 4 0.0113 PF11825 Protein of unknown function (DUF3345), 0.0107 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0098 PF00146 NADH dehydrogenase 0.0095 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0092 PF00757 Furin-like cysteine rich region 0.0092 PF01030 Receptor L domain 0.0081 PF07884 Vitamin K epoxide reductase family 0.0080 PF00167 Fibroblast growth factor 0.0072 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0070 PF03171 2OG-Fe(II), oxygenase superfamily 0.0059 PF08718 Glycolipid transfer protein (GLTP), 0.0054 PF00689 Cation transporting ATPase, C-terminus 0.0054 PF00690 Cation transporter/ATPase, N-terminus 0.0052 PF02214 K+ channel tetramerisation domain 0.0052 PF00405 Transferrin 0.0049 PF03765 CRAL/TRIO, N-terminus 0.0049 PF00650 CRAL/TRIO domain 0.0048 PF00143 Interferon alpha/beta domain 0.0048 PF00342 Phosphoglucose isomerase 0.0048 PF07648 Kazal-type serine protease inhibitor domain 0.0048 PF02065 Melibiase 0.0044 PF00224 Pyruvate kinase, barrel domain 0.0044 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0044 PF02887 Pyruvate kinase, alpha/beta domain 0.0043 PF00122 E1-E2 ATPase 0.0042 PF00168 C2 domain 0.0042 PF03414 Glycosyltransferase family 6 0.0038 PF00432 Prenyltransferase and squalene oxidase repeat 0.0038 PF07654 Immunoglobulin C1-set domain 0.0034 PF00459 Inositol monophosphatase family 0.0034 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0034 PF08702 Fibrinogen alpha/beta chain family 0.0031 PF00487 Fatty acid desaturase 0.0031 PF03160 Calx-beta domain 0.0029 PF00293 NUDIX domain 0.0029 PF12160 Fibrinogen alpha C domain 0.0029 PF01187 Macrophage migration inhibitory factor (MIF), 0.0029 PF09164 Vitamin D binding protein, domain III 0.0029 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0029 PF03781 Formylglycine-generating sulfatase enzyme 0.0029 PF00884 Sulfatase 0.0029 PF01699 Sodium/calcium exchanger protein 0.0028 PF00248 Aldo/keto reductase family 0.0027 PF00549 CoA-ligase 0.0026 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0025 PF00390 Malic enzyme, N-terminal domain 0.0025 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0025 PF03949 Malic enzyme, NAD binding domain 0.0024 PF00702 haloacid dehalogenase-like hydrolase 0.0024 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0023 PF08442 ATP-grasp domain 0.0023 PF07690 Major Facilitator Superfamily 0.0023 PF00821 Phosphoenolpyruvate carboxykinase 0.0023 PF00939 Sodium:sulfate symporter transmembrane region 0.0022 PF08534 Redoxin 0.0022 PF00041 Fibronectin type III domain 0.0022 PF00489 Interleukin-6/G-CSF/MGF family 0.0020 PF06617 M-phase inducer phosphatase 0.0020 PF00581 Rhodanese-like domain 0.0019 PF00194 Eukaryotic-type carbonic anhydrase 0.0018 PF03727 Hexokinase 0.0018 PF00084 Sushi domain (SCR repeat), 0.0018 PF00349 Hexokinase 0.0017 PF01144 Coenzyme A transferase 0.0017 PF00890 FAD binding domain 0.0017 PF07686 Immunoglobulin V-set domain 0.0017 PF00019 Transforming growth factor beta like domain 0.0017 PF00688 TGF-beta propeptide 0.0016 PF00149 Calcineurin-like phosphoesterase 0.0016 PF02525 Flavodoxin-like fold 0.0016 PF00337 Galactoside-binding lectin 0.0016 PF00089 Trypsin 0.0013 PF00106 short chain dehydrogenase 0.0012 PF00328 Histidine acid phosphatase 0.0012 PF01532 Glycosyl hydrolase family 47 0.0012 PF03770 Inositol polyphosphate kinase 0.0012 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 0.0011 PF01391 Collagen triple helix repeat (20 copies), 0.0011 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0011 PF00682 HMGL-like 0.0011 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0009 PF02910 domain 0.0009 PF07732 Multicopper oxidase 0.0009 PF00860 Permease family 0.0009 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0009 PF00703 domain 0.0009 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0009 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0009 PF00031 Cystatin domain 0.0009 PF02145 Rap/ran-GAP 0.0009 PF02373 JmjC domain 0.0009 PF07970 Endoplasmic reticulum vesicle transporter 0.0009 PF01363 FYVE zinc finger 0.0009 PF02210 Laminin G domain 0.0009 PF02375 jmjN domain 0.0009 PF00778 DIX domain 0.0009 PF08824 Serine rich protein interaction domain 0.0009 PF02984 Cyclin, C-terminal domain 0.0009 PF04055 Radical SAM superfamily 0.0009 PF00134 Cyclin, N-terminal domain 0.0009 PF00969 Class II histocompatibility antigen, beta domain 0.0009 PF00762 Ferrochelatase 0.0009 PF04051 Transport protein particle (TRAPP), component 0.0009 PF00093 von Willebrand factor type C domain 0.0009 PF08429 PLU-1-like protein 0.0009 PF00090 Thrombospondin type 1 domain 0.0009 PF02928 C5HC2 zinc finger 0.0009 PF01151 GNS1/SUR4 family 0.0009 PF01118 Semialdehyde dehydrogenase, NAD binding domain 0.0009 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0009 PF04756 OST3 / OST6 family 0.0009 PF02629 CoA binding domain 0.0009 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0009 PF08917 Transforming growth factor beta receptor 2 ectodomain 0.0009 PF01562 Reprolysin family propeptide 0.0009 PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit 0.0009 PF05328 CybS 0.0009 PF01388 ARID/BRIGHT DNA binding domain 0.0009 PF00071 Ras family 0.0009 PF06907 Latexin 0.0009 PF02970 Tubulin binding cofactor A 0.0009 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0009 PF12126 Protein of unknown function (DUF3583), 0.0009 PF00631 GGL domain 0.0009 PF08516 ADAM cysteine-rich 0.0009 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0009 PF03453 MoeA N-terminal region (domain I and II), 0.0009 PF03454 MoeA C-terminal region (domain IV), 0.0009 PF00246 Zinc carboxypeptidase 0.0009 PF08321 PPP5 0.0009 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0009 PF00200 Disintegrin 0.0009 PF00514 Armadillo/beta-catenin-like repeat 0.0009 PF01753 MYND finger 0.0009 PF02188 GoLoco motif 0.0009 PF12026 Domain of unknown function (DUF3513), 0.0009 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0009 PF02121 Phosphatidylinositol transfer protein 0.0009 PF00236 Glycoprotein hormone 0.0009 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0009 PF08833 Axin beta-catenin binding domain 0.0009 PF00628 PHD-finger 0.0009 PF05586 Anthrax receptor C-terminus region 0.0009 PF00021 u-PAR/Ly-6 domain 0.0009 PF00270 DEAD/DEAH box helicase 0.0009 PF05735 Thrombospondin C-terminal region 0.0009 PF01042 Endoribonuclease L-PSP 0.0009 PF00403 Heavy-metal-associated domain 0.0009 PF00274 Fructose-bisphosphate aldolase class-I 0.0009 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0009 PF04711 Apolipoprotein A-II (ApoA-II), 0.0009 PF05587 Anthrax receptor extracellular domain 0.0009 PF00994 Probable molybdopterin binding domain 0.0009 PF03572 Peptidase family S41 0.0009 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0009 PF01161 Phosphatidylethanolamine-binding protein 0.0009 PF02828 L27 domain 0.0009 PF00806 Pumilio-family RNA binding repeat 0.0008 PF01477 PLAT/LH2 domain 0.0007 PF00433 Protein kinase C terminal domain 0.0007 PF00305 Lipoxygenase 0.0004 PF00059 Lectin C-type domain 0.0004 PF00067 Cytochrome P450 0.0004 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0004 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0004 PF07645 Calcium-binding EGF domain 0.0003 PF00560 Leucine Rich Repeat 0.0002 PF01425 Amidase 0.0002 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0002 PF10420 Cytokine interleukin-12p40 C-terminus 0.0001 PF02055 O-Glycosyl hydrolase family 30 0.0001 PF00212 Atrial natriuretic peptide 0.0001 PF05118 Aspartyl/Asparaginyl beta-hydroxylase 0.0001 PF03351 DOMON domain 0.0001 PF02436 Conserved carboxylase domain 0.0001 PF00431 CUB domain 0.0001 PF03062 MBOAT family 0.0001 PF02780 Transketolase, C-terminal domain 0.0001 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0001 PF00265 Thymidine kinase 0.0001 PF01227 GTP cyclohydrolase I 0.0001 PF00574 Clp protease 0.0001 PF01369 Sec7 domain 0.0001 PF00714 Interferon gamma SUB428 C(#C)(-C) 0.2458 PF02159 Oestrogen receptor 0.1822 PF02161 Progesterone receptor 0.1457 PF00105 Zinc finger, C4 type (two domains), 0.1438 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0439 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0439 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0400 PF01593 Flavin containing amine oxidoreductase 0.0399 PF02155 Glucocorticoid receptor 0.0253 PF00191 Annexin 0.0235 PF00273 Serum albumin family 0.0164 PF00039 Fibronectin type I domain 0.0159 PF03098 Animal haem peroxidase 0.0156 PF02166 Androgen receptor 0.0136 PF08491 Squalene epoxidase 0.0135 PF00079 Serpin (serine protease inhibitor), 0.0125 PF00576 HIUase/Transthyretin family 0.0118 PF01735 Lysophospholipase catalytic domain 0.0116 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0116 PF02180 Bcl-2 homology region 4 0.0113 PF11825 Protein of unknown function (DUF3345), 0.0107 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0098 PF00146 NADH dehydrogenase 0.0095 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0092 PF01030 Receptor L domain 0.0092 PF00757 Furin-like cysteine rich region 0.0081 PF07884 Vitamin K epoxide reductase family 0.0080 PF00167 Fibroblast growth factor 0.0072 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0070 PF03171 2OG-Fe(II), oxygenase superfamily 0.0059 PF08718 Glycolipid transfer protein (GLTP), 0.0054 PF00689 Cation transporting ATPase, C-terminus 0.0054 PF00690 Cation transporter/ATPase, N-terminus 0.0052 PF02214 K+ channel tetramerisation domain 0.0052 PF00405 Transferrin 0.0049 PF03765 CRAL/TRIO, N-terminus 0.0049 PF00650 CRAL/TRIO domain 0.0048 PF00143 Interferon alpha/beta domain 0.0048 PF07648 Kazal-type serine protease inhibitor domain 0.0048 PF00342 Phosphoglucose isomerase 0.0048 PF02065 Melibiase 0.0044 PF02887 Pyruvate kinase, alpha/beta domain 0.0044 PF00224 Pyruvate kinase, barrel domain 0.0044 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0043 PF00122 E1-E2 ATPase 0.0042 PF03414 Glycosyltransferase family 6 0.0042 PF00168 C2 domain 0.0038 PF00432 Prenyltransferase and squalene oxidase repeat 0.0038 PF07654 Immunoglobulin C1-set domain 0.0034 PF00459 Inositol monophosphatase family 0.0034 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0034 PF08702 Fibrinogen alpha/beta chain family 0.0031 PF03160 Calx-beta domain 0.0031 PF00487 Fatty acid desaturase 0.0029 PF03781 Formylglycine-generating sulfatase enzyme 0.0029 PF12160 Fibrinogen alpha C domain 0.0029 PF01699 Sodium/calcium exchanger protein 0.0029 PF00293 NUDIX domain 0.0029 PF00884 Sulfatase 0.0029 PF01187 Macrophage migration inhibitory factor (MIF), 0.0029 PF09164 Vitamin D binding protein, domain III 0.0029 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0028 PF00248 Aldo/keto reductase family 0.0027 PF00549 CoA-ligase 0.0026 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0025 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0025 PF03949 Malic enzyme, NAD binding domain 0.0025 PF00390 Malic enzyme, N-terminal domain 0.0024 PF00702 haloacid dehalogenase-like hydrolase 0.0024 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0023 PF07690 Major Facilitator Superfamily 0.0023 PF08442 ATP-grasp domain 0.0023 PF00821 Phosphoenolpyruvate carboxykinase 0.0023 PF00939 Sodium:sulfate symporter transmembrane region 0.0022 PF00489 Interleukin-6/G-CSF/MGF family 0.0022 PF00041 Fibronectin type III domain 0.0022 PF08534 Redoxin 0.0020 PF06617 M-phase inducer phosphatase 0.0020 PF00581 Rhodanese-like domain 0.0019 PF00194 Eukaryotic-type carbonic anhydrase 0.0018 PF00349 Hexokinase 0.0018 PF03727 Hexokinase 0.0018 PF00084 Sushi domain (SCR repeat), 0.0017 PF00688 TGF-beta propeptide 0.0017 PF01144 Coenzyme A transferase 0.0017 PF07686 Immunoglobulin V-set domain 0.0017 PF00019 Transforming growth factor beta like domain 0.0017 PF00890 FAD binding domain 0.0016 PF00337 Galactoside-binding lectin 0.0016 PF02525 Flavodoxin-like fold 0.0016 PF00149 Calcineurin-like phosphoesterase 0.0016 PF00089 Trypsin 0.0013 PF00106 short chain dehydrogenase 0.0012 PF03770 Inositol polyphosphate kinase 0.0012 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 0.0012 PF00328 Histidine acid phosphatase 0.0012 PF01532 Glycosyl hydrolase family 47 0.0011 PF00682 HMGL-like 0.0011 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0011 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0011 PF01391 Collagen triple helix repeat (20 copies), 0.0009 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0009 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0009 PF00021 u-PAR/Ly-6 domain 0.0009 PF00860 Permease family 0.0009 PF00628 PHD-finger 0.0009 PF05735 Thrombospondin C-terminal region 0.0009 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0009 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0009 PF00200 Disintegrin 0.0009 PF03453 MoeA N-terminal region (domain I and II), 0.0009 PF00246 Zinc carboxypeptidase 0.0009 PF02375 jmjN domain 0.0009 PF08516 ADAM cysteine-rich 0.0009 PF06907 Latexin 0.0009 PF01042 Endoribonuclease L-PSP 0.0009 PF03454 MoeA C-terminal region (domain IV), 0.0009 PF00071 Ras family 0.0009 PF02373 JmjC domain 0.0009 PF00236 Glycoprotein hormone 0.0009 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0009 PF01388 ARID/BRIGHT DNA binding domain 0.0009 PF02984 Cyclin, C-terminal domain 0.0009 PF00703 domain 0.0009 PF04055 Radical SAM superfamily 0.0009 PF02910 domain 0.0009 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0009 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0009 PF04051 Transport protein particle (TRAPP), component 0.0009 PF02121 Phosphatidylinositol transfer protein 0.0009 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0009 PF00270 DEAD/DEAH box helicase 0.0009 PF02210 Laminin G domain 0.0009 PF01151 GNS1/SUR4 family 0.0009 PF12026 Domain of unknown function (DUF3513), 0.0009 PF01562 Reprolysin family propeptide 0.0009 PF02188 GoLoco motif 0.0009 PF00969 Class II histocompatibility antigen, beta domain 0.0009 PF00134 Cyclin, N-terminal domain 0.0009 PF00403 Heavy-metal-associated domain 0.0009 PF12126 Protein of unknown function (DUF3583), 0.0009 PF00274 Fructose-bisphosphate aldolase class-I 0.0009 PF00093 von Willebrand factor type C domain 0.0009 PF00090 Thrombospondin type 1 domain 0.0009 PF05586 Anthrax receptor C-terminus region 0.0009 PF08429 PLU-1-like protein 0.0009 PF03572 Peptidase family S41 0.0009 PF01363 FYVE zinc finger 0.0009 PF05587 Anthrax receptor extracellular domain 0.0009 PF02629 CoA binding domain 0.0009 PF08824 Serine rich protein interaction domain 0.0009 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0009 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0009 PF00631 GGL domain 0.0009 PF02928 C5HC2 zinc finger 0.0009 PF07970 Endoplasmic reticulum vesicle transporter 0.0009 PF02145 Rap/ran-GAP 0.0009 PF01753 MYND finger 0.0009 PF08917 Transforming growth factor beta receptor 2 ectodomain 0.0009 PF00806 Pumilio-family RNA binding repeat 0.0009 PF07732 Multicopper oxidase 0.0009 PF08321 PPP5 0.0009 PF00994 Probable molybdopterin binding domain 0.0009 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0009 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0009 PF02828 L27 domain 0.0009 PF00514 Armadillo/beta-catenin-like repeat 0.0009 PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit 0.0009 PF00031 Cystatin domain 0.0009 PF00762 Ferrochelatase 0.0009 PF08833 Axin beta-catenin binding domain 0.0009 PF01161 Phosphatidylethanolamine-binding protein 0.0009 PF04756 OST3 / OST6 family 0.0009 PF00778 DIX domain 0.0009 PF01118 Semialdehyde dehydrogenase, NAD binding domain 0.0009 PF02970 Tubulin binding cofactor A 0.0009 PF04711 Apolipoprotein A-II (ApoA-II), 0.0009 PF05328 CybS 0.0008 PF01477 PLAT/LH2 domain 0.0007 PF00433 Protein kinase C terminal domain 0.0007 PF00305 Lipoxygenase 0.0004 PF00059 Lectin C-type domain 0.0004 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0004 PF00067 Cytochrome P450 0.0004 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0004 PF07645 Calcium-binding EGF domain 0.0003 PF00560 Leucine Rich Repeat 0.0002 PF01425 Amidase 0.0002 PF10420 Cytokine interleukin-12p40 C-terminus 0.0002 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0001 PF00265 Thymidine kinase 0.0001 PF01227 GTP cyclohydrolase I 0.0001 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0001 PF01369 Sec7 domain 0.0001 PF00431 CUB domain 0.0001 PF00714 Interferon gamma 0.0001 PF00574 Clp protease 0.0001 PF02436 Conserved carboxylase domain 0.0001 PF05118 Aspartyl/Asparaginyl beta-hydroxylase 0.0001 PF03351 DOMON domain 0.0001 PF02780 Transketolase, C-terminal domain 0.0001 PF00212 Atrial natriuretic peptide 0.0001 PF02055 O-Glycosyl hydrolase family 30 0.0001 PF03062 MBOAT family SUB679 C-C-C=C-C 0.2458 PF00001 7 transmembrane receptor (rhodopsin family), 0.1129 PF02159 Oestrogen receptor 0.1049 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.1043 PF00105 Zinc finger, C4 type (two domains), 0.1036 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0996 PF03098 Animal haem peroxidase 0.0698 PF00209 Sodium:neurotransmitter symporter family 0.0481 PF06512 Sodium ion transport-associated 0.0477 PF08070 DTHCT (NUC029), region 0.0477 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0477 PF00204 DNA gyrase B 0.0378 PF00520 Ion transport protein 0.0292 PF03073 TspO/MBR family 0.0291 PF00191 Annexin 0.0278 PF02161 Progesterone receptor 0.0239 PF00194 Eukaryotic-type carbonic anhydrase 0.0226 PF00989 PAS fold 0.0216 PF09396 Thrombin light chain 0.0211 PF02155 Glucocorticoid receptor 0.0182 PF00067 Cytochrome P450 0.0182 PF00027 Cyclic nucleotide-binding domain 0.0134 PF01593 Flavin containing amine oxidoreductase 0.0094 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0082 PF00186 Dihydrofolate reductase 0.0078 PF01735 Lysophospholipase catalytic domain 0.0069 PF12497 Estrogen receptor beta 0.0068 PF01007 Inward rectifier potassium channel 0.0065 PF00305 Lipoxygenase 0.0052 PF00005 ABC transporter 0.0050 PF08403 Amino acid permease N-terminal 0.0038 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0038 PF00102 Protein-tyrosine phosphatase 0.0034 PF00576 HIUase/Transthyretin family 0.0023 PF00273 Serum albumin family 0.0021 PF00664 ABC transporter transmembrane region 0.0007 PF00091 Tubulin/FtsZ family, GTPase domain 0.0007 PF03953 Tubulin C-terminal domain 0.0006 PF07884 Vitamin K epoxide reductase family 0.0001 PF05649 Peptidase family M13 0.0001 PF01431 Peptidase family M13 SUB690 O-C-C-C-C-C-C 0.2453 PF02159 Oestrogen receptor 0.1815 PF00105 Zinc finger, C4 type (two domains), 0.1786 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1002 PF00001 7 transmembrane receptor (rhodopsin family), 0.0985 PF00191 Annexin 0.0978 PF00204 DNA gyrase B 0.0978 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0978 PF08070 DTHCT (NUC029), region 0.0930 PF02155 Glucocorticoid receptor 0.0694 PF02161 Progesterone receptor 0.0505 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0490 PF01735 Lysophospholipase catalytic domain 0.0460 PF00079 Serpin (serine protease inhibitor), 0.0424 PF03953 Tubulin C-terminal domain 0.0424 PF00091 Tubulin/FtsZ family, GTPase domain 0.0391 PF02166 Androgen receptor 0.0345 PF08384 Pro-opiomelanocortin, N-terminal region 0.0345 PF00976 Corticotropin ACTH domain 0.0345 PF08035 Opioids neuropeptide 0.0344 PF00005 ABC transporter 0.0334 PF12497 Estrogen receptor beta 0.0317 PF00989 PAS fold 0.0308 PF00664 ABC transporter transmembrane region 0.0263 PF00027 Cyclic nucleotide-binding domain 0.0216 PF00168 C2 domain 0.0197 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0153 PF00273 Serum albumin family 0.0130 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0128 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0125 PF01477 PLAT/LH2 domain 0.0124 PF03414 Glycosyltransferase family 6 0.0112 PF00822 PMP-22/EMP/MP20/Claudin family 0.0102 PF00067 Cytochrome P450 0.0101 PF01401 Angiotensin-converting enzyme 0.0084 PF02806 Alpha amylase, C-terminal all-beta domain 0.0076 PF11825 Protein of unknown function (DUF3345), 0.0070 PF03098 Animal haem peroxidase 0.0067 PF07966 A1 Propeptide 0.0057 PF00305 Lipoxygenase 0.0052 PF00026 Eukaryotic aspartyl protease 0.0044 PF07648 Kazal-type serine protease inhibitor domain 0.0041 PF09396 Thrombin light chain 0.0032 PF00151 Lipase 0.0031 PF01061 ABC-2 type transporter 0.0031 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0029 PF00183 Hsp90 protein 0.0028 PF00340 Interleukin-1 / 18 0.0028 PF02394 Interleukin-1 propeptide 0.0024 PF00186 Dihydrofolate reductase 0.0024 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0023 PF07884 Vitamin K epoxide reductase family 0.0021 PF00643 B-box zinc finger 0.0020 PF00059 Lectin C-type domain 0.0018 PF08441 Integrin alpha 0.0018 PF08763 Voltage gated calcium channel IQ domain 0.0018 PF00229 TNF(Tumour Necrosis Factor), family 0.0014 PF00042 Globin 0.0011 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0011 PF00051 Kringle domain 0.0008 PF00128 Alpha amylase, catalytic domain 0.0008 PF02259 FAT domain 0.0008 PF02260 FATC domain 0.0008 PF08771 Rapamycin binding domain 0.0007 PF03765 CRAL/TRIO, N-terminus 0.0007 PF00650 CRAL/TRIO domain 0.0007 PF04622 ERG2 and Sigma1 receptor like protein 0.0005 PF06327 Domain of Unknown Function (DUF1053), 0.0005 PF00554 Rel homology domain (RHD), 0.0005 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0004 PF00357 Integrin alpha cytoplasmic region 0.0003 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0003 PF07885 Ion channel 0.0003 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0003 PF03062 MBOAT family 0.0003 PF02180 Bcl-2 homology region 4 0.0002 PF00212 Atrial natriuretic peptide 0.0002 PF00341 Platelet-derived growth factor (PDGF), SUB709 C-C(C)-C-C 0.2453 PF00001 7 transmembrane receptor (rhodopsin family), 0.2056 PF02159 Oestrogen receptor 0.1725 PF00105 Zinc finger, C4 type (two domains), 0.1718 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1366 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.1057 PF08070 DTHCT (NUC029), region 0.1057 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1057 PF00204 DNA gyrase B 0.0887 PF00209 Sodium:neurotransmitter symporter family 0.0727 PF03098 Animal haem peroxidase 0.0605 PF06512 Sodium ion transport-associated 0.0556 PF02161 Progesterone receptor 0.0520 PF00191 Annexin 0.0496 PF09396 Thrombin light chain 0.0456 PF00520 Ion transport protein 0.0389 PF02155 Glucocorticoid receptor 0.0375 PF00989 PAS fold 0.0328 PF03073 TspO/MBR family 0.0297 PF00067 Cytochrome P450 0.0281 PF00027 Cyclic nucleotide-binding domain 0.0264 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0259 PF02166 Androgen receptor 0.0183 PF03953 Tubulin C-terminal domain 0.0183 PF00091 Tubulin/FtsZ family, GTPase domain 0.0144 PF01735 Lysophospholipase catalytic domain 0.0139 PF00005 ABC transporter 0.0138 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0138 PF00102 Protein-tyrosine phosphatase 0.0126 PF12497 Estrogen receptor beta 0.0098 PF00186 Dihydrofolate reductase 0.0081 PF00664 ABC transporter transmembrane region 0.0080 PF00305 Lipoxygenase 0.0010 PF07884 Vitamin K epoxide reductase family SUB588 N-C:C-O-[#1] 0.2451 PF00155 Aminotransferase class I and II 0.2351 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.2321 PF00266 Aminotransferase class-V 0.1717 PF00464 Serine hydroxymethyltransferase 0.1534 PF00291 Pyridoxal-phosphate dependent enzyme 0.1460 PF00202 Aminotransferase class-III 0.1392 PF01063 Aminotransferase class IV 0.1350 PF00343 Carbohydrate phosphorylase 0.1133 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.1133 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0967 PF00294 pfkB family carbohydrate kinase 0.0767 PF00702 haloacid dehalogenase-like hydrolase 0.0568 PF03473 MOSC domain 0.0568 PF03476 MOSC N-terminal beta barrel domain 0.0568 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0567 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0567 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0559 PF02347 Glycine cleavage system P-protein 0.0559 PF01168 Alanine racemase, N-terminal domain 0.0559 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0559 PF01202 Shikimate kinase 0.0559 PF01212 Beta-eliminating lyase 0.0549 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0549 PF04961 Formiminotransferase-cyclodeaminase 0.0549 PF02971 Formiminotransferase domain 0.0539 PF07706 Aminotransferase ubiquitination site 0.0406 PF01596 O-methyltransferase 0.0353 PF00571 CBS domain 0.0142 PF00340 Interleukin-1 / 18 0.0142 PF02394 Interleukin-1 propeptide 0.0126 PF00342 Phosphoglucose isomerase 0.0115 PF00690 Cation transporter/ATPase, N-terminus 0.0115 PF00689 Cation transporting ATPase, C-terminus 0.0094 PF01588 Putative tRNA binding domain 0.0093 PF00576 HIUase/Transthyretin family 0.0085 PF00122 E1-E2 ATPase 0.0081 PF01916 Deoxyhypusine synthase 0.0047 PF00204 DNA gyrase B 0.0047 PF08070 DTHCT (NUC029), region 0.0047 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0042 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0033 PF00149 Calcineurin-like phosphoesterase SUB551 Cl-C-C-C 0.2450 PF03073 TspO/MBR family 0.1726 PF00194 Eukaryotic-type carbonic anhydrase 0.1286 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1286 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1234 PF08403 Amino acid permease N-terminal 0.1059 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1059 PF02254 TrkA-N domain 0.0551 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0476 PF00209 Sodium:neurotransmitter symporter family 0.0449 PF00001 7 transmembrane receptor (rhodopsin family), 0.0422 PF00324 Amino acid permease 0.0385 PF00520 Ion transport protein 0.0263 PF00018 SH3 domain 0.0256 PF00069 Protein kinase domain 0.0238 PF00757 Furin-like cysteine rich region 0.0238 PF01030 Receptor L domain 0.0234 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0230 PF03098 Animal haem peroxidase 0.0222 PF00690 Cation transporter/ATPase, N-terminus 0.0222 PF00689 Cation transporting ATPase, C-terminus 0.0204 PF00017 SH2 domain 0.0199 PF00186 Dihydrofolate reductase 0.0183 PF00305 Lipoxygenase 0.0182 PF00122 E1-E2 ATPase 0.0165 PF01477 PLAT/LH2 domain 0.0160 PF00664 ABC transporter transmembrane region 0.0155 PF06512 Sodium ion transport-associated 0.0138 PF08919 F-actin binding 0.0138 PF00005 ABC transporter 0.0131 PF00702 haloacid dehalogenase-like hydrolase 0.0130 PF00989 PAS fold 0.0128 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0123 PF01007 Inward rectifier potassium channel 0.0118 PF00067 Cytochrome P450 0.0109 PF02196 Raf-like Ras-binding domain 0.0107 PF03630 Fumble 0.0107 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0107 PF02060 Slow voltage-gated potassium channel 0.0107 PF02038 ATP1G1/PLM/MAT8 family 0.0107 PF01734 Patatin-like phospholipase 0.0107 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0099 PF00243 Nerve growth factor family 0.0099 PF00612 IQ calmodulin-binding motif 0.0081 PF00027 Cyclic nucleotide-binding domain 0.0081 PF00536 SAM domain (Sterile alpha motif), 0.0081 PF01404 Ephrin receptor ligand binding domain 0.0071 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0071 PF00533 BRCA1 C Terminus (BRCT), domain 0.0071 PF05406 WGR domain 0.0071 PF08063 PADR1 (NUC008), domain 0.0071 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0070 PF03530 Calcium-activated SK potassium channel 0.0070 PF02888 Calmodulin binding domain 0.0054 PF00042 Globin 0.0047 PF00343 Carbohydrate phosphorylase 0.0039 PF01582 TIR domain 0.0039 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0039 PF00675 Insulinase (Peptidase family M16), 0.0039 PF05193 Peptidase M16 inactive domain 0.0039 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0039 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0036 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0033 PF02865 STAT protein, protein interaction domain 0.0033 PF02864 STAT protein, DNA binding domain 0.0033 PF01017 STAT protein, all-alpha domain 0.0025 PF03520 KCNQ voltage-gated potassium channel 0.0015 PF00976 Corticotropin ACTH domain 0.0015 PF08035 Opioids neuropeptide 0.0015 PF08384 Pro-opiomelanocortin, N-terminal region 0.0013 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0012 PF00576 HIUase/Transthyretin family 0.0012 PF01094 Receptor family ligand binding region 0.0009 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0005 PF00060 Ligand-gated ion channel 0.0005 PF00111 2Fe-2S iron-sulfur cluster binding domain SUB363 C(~Cl)(:C) 0.2447 PF03073 TspO/MBR family 0.1606 PF00194 Eukaryotic-type carbonic anhydrase 0.1355 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1355 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1156 PF08403 Amino acid permease N-terminal 0.0993 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0993 PF02254 TrkA-N domain 0.0525 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0451 PF00209 Sodium:neurotransmitter symporter family 0.0425 PF00001 7 transmembrane receptor (rhodopsin family), 0.0394 PF00324 Amino acid permease 0.0365 PF00520 Ion transport protein 0.0253 PF00018 SH3 domain 0.0239 PF00069 Protein kinase domain 0.0220 PF00757 Furin-like cysteine rich region 0.0220 PF01030 Receptor L domain 0.0216 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0213 PF03098 Animal haem peroxidase 0.0210 PF00690 Cation transporter/ATPase, N-terminus 0.0210 PF00689 Cation transporting ATPase, C-terminus 0.0197 PF00017 SH2 domain 0.0194 PF00186 Dihydrofolate reductase 0.0173 PF00122 E1-E2 ATPase 0.0169 PF00305 Lipoxygenase 0.0153 PF01477 PLAT/LH2 domain 0.0153 PF00664 ABC transporter transmembrane region 0.0151 PF06512 Sodium ion transport-associated 0.0135 PF00989 PAS fold 0.0135 PF08919 F-actin binding 0.0132 PF00005 ABC transporter 0.0124 PF00702 haloacid dehalogenase-like hydrolase 0.0122 PF01007 Inward rectifier potassium channel 0.0118 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0113 PF02196 Raf-like Ras-binding domain 0.0109 PF00067 Cytochrome P450 0.0100 PF02060 Slow voltage-gated potassium channel 0.0100 PF01734 Patatin-like phospholipase 0.0100 PF03630 Fumble 0.0100 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0100 PF02038 ATP1G1/PLM/MAT8 family 0.0100 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0097 PF00612 IQ calmodulin-binding motif 0.0097 PF00243 Nerve growth factor family 0.0087 PF00027 Cyclic nucleotide-binding domain 0.0080 PF00536 SAM domain (Sterile alpha motif), 0.0080 PF01404 Ephrin receptor ligand binding domain 0.0066 PF03530 Calcium-activated SK potassium channel 0.0066 PF02888 Calmodulin binding domain 0.0066 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0066 PF00533 BRCA1 C Terminus (BRCT), domain 0.0066 PF08063 PADR1 (NUC008), domain 0.0066 PF05406 WGR domain 0.0066 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0062 PF00343 Carbohydrate phosphorylase 0.0050 PF00042 Globin 0.0043 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0036 PF05193 Peptidase M16 inactive domain 0.0036 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0036 PF00675 Insulinase (Peptidase family M16), 0.0036 PF01582 TIR domain 0.0036 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0036 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0034 PF01017 STAT protein, all-alpha domain 0.0034 PF02864 STAT protein, DNA binding domain 0.0034 PF02865 STAT protein, protein interaction domain 0.0024 PF03520 KCNQ voltage-gated potassium channel 0.0014 PF00976 Corticotropin ACTH domain 0.0014 PF08035 Opioids neuropeptide 0.0014 PF08384 Pro-opiomelanocortin, N-terminal region 0.0012 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0011 PF00576 HIUase/Transthyretin family 0.0011 PF01094 Receptor family ligand binding region 0.0008 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0005 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0005 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0004 PF00060 Ligand-gated ion channel 0.0003 PF01234 NNMT/PNMT/TEMT family 0.0003 PF00191 Annexin 0.0001 PF08399 VWA N-terminal 0.0001 PF07686 Immunoglobulin V-set domain 0.0001 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0001 PF02743 Cache domain 0.0001 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0001 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain SUB502 Cl-C:C-C 0.2431 PF03073 TspO/MBR family 0.1558 PF00194 Eukaryotic-type carbonic anhydrase 0.1368 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1368 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1124 PF08403 Amino acid permease N-terminal 0.0966 PF02254 TrkA-N domain 0.0966 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0513 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0440 PF00209 Sodium:neurotransmitter symporter family 0.0414 PF00001 7 transmembrane receptor (rhodopsin family), 0.0383 PF00324 Amino acid permease 0.0356 PF00520 Ion transport protein 0.0249 PF00018 SH3 domain 0.0232 PF00069 Protein kinase domain 0.0213 PF01030 Receptor L domain 0.0213 PF00757 Furin-like cysteine rich region 0.0209 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0206 PF03098 Animal haem peroxidase 0.0205 PF00690 Cation transporter/ATPase, N-terminus 0.0205 PF00689 Cation transporting ATPase, C-terminus 0.0193 PF00017 SH2 domain 0.0191 PF00186 Dihydrofolate reductase 0.0169 PF00122 E1-E2 ATPase 0.0163 PF00305 Lipoxygenase 0.0150 PF00664 ABC transporter transmembrane region 0.0149 PF06512 Sodium ion transport-associated 0.0148 PF01477 PLAT/LH2 domain 0.0136 PF00989 PAS fold 0.0133 PF08919 F-actin binding 0.0130 PF00005 ABC transporter 0.0121 PF00702 haloacid dehalogenase-like hydrolase 0.0121 PF01007 Inward rectifier potassium channel 0.0114 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0114 PF02196 Raf-like Ras-binding domain 0.0106 PF00067 Cytochrome P450 0.0097 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0097 PF03630 Fumble 0.0097 PF01734 Patatin-like phospholipase 0.0097 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0097 PF02038 ATP1G1/PLM/MAT8 family 0.0097 PF02060 Slow voltage-gated potassium channel 0.0096 PF00612 IQ calmodulin-binding motif 0.0096 PF00243 Nerve growth factor family 0.0088 PF00027 Cyclic nucleotide-binding domain 0.0080 PF00536 SAM domain (Sterile alpha motif), 0.0080 PF01404 Ephrin receptor ligand binding domain 0.0066 PF00343 Carbohydrate phosphorylase 0.0064 PF02888 Calmodulin binding domain 0.0064 PF03530 Calcium-activated SK potassium channel 0.0063 PF00533 BRCA1 C Terminus (BRCT), domain 0.0063 PF05406 WGR domain 0.0063 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0063 PF08063 PADR1 (NUC008), domain 0.0063 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0048 PF00042 Globin 0.0045 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0035 PF02865 STAT protein, protein interaction domain 0.0035 PF05193 Peptidase M16 inactive domain 0.0035 PF02864 STAT protein, DNA binding domain 0.0035 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0035 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0035 PF00675 Insulinase (Peptidase family M16), 0.0035 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0035 PF01017 STAT protein, all-alpha domain 0.0035 PF01582 TIR domain 0.0023 PF03520 KCNQ voltage-gated potassium channel 0.0013 PF08384 Pro-opiomelanocortin, N-terminal region 0.0013 PF08035 Opioids neuropeptide 0.0013 PF00976 Corticotropin ACTH domain 0.0011 PF00576 HIUase/Transthyretin family 0.0011 PF01094 Receptor family ligand binding region 0.0011 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0008 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0006 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0005 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0004 PF01234 NNMT/PNMT/TEMT family 0.0004 PF00191 Annexin 0.0004 PF00060 Ligand-gated ion channel 0.0002 PF02743 Cache domain 0.0002 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0002 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0002 PF08399 VWA N-terminal 0.0001 PF07686 Immunoglobulin V-set domain 0.0001 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0001 PF00146 NADH dehydrogenase SUB599 Cl-C:C:C-C 0.2417 PF03073 TspO/MBR family 0.1526 PF00194 Eukaryotic-type carbonic anhydrase 0.1373 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1373 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1103 PF08403 Amino acid permease N-terminal 0.0948 PF02254 TrkA-N domain 0.0948 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0505 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0433 PF00209 Sodium:neurotransmitter symporter family 0.0407 PF00001 7 transmembrane receptor (rhodopsin family), 0.0375 PF00324 Amino acid permease 0.0350 PF00520 Ion transport protein 0.0245 PF00018 SH3 domain 0.0228 PF00069 Protein kinase domain 0.0208 PF01030 Receptor L domain 0.0208 PF00757 Furin-like cysteine rich region 0.0205 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0202 PF00689 Cation transporting ATPase, C-terminus 0.0202 PF00690 Cation transporter/ATPase, N-terminus 0.0201 PF03098 Animal haem peroxidase 0.0191 PF00017 SH2 domain 0.0189 PF00186 Dihydrofolate reductase 0.0166 PF00122 E1-E2 ATPase 0.0160 PF00305 Lipoxygenase 0.0148 PF06512 Sodium ion transport-associated 0.0148 PF00664 ABC transporter transmembrane region 0.0145 PF01477 PLAT/LH2 domain 0.0136 PF00989 PAS fold 0.0131 PF08919 F-actin binding 0.0128 PF00005 ABC transporter 0.0120 PF01007 Inward rectifier potassium channel 0.0119 PF00702 haloacid dehalogenase-like hydrolase 0.0114 PF02196 Raf-like Ras-binding domain 0.0112 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0103 PF00067 Cytochrome P450 0.0095 PF00612 IQ calmodulin-binding motif 0.0095 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0095 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0095 PF01734 Patatin-like phospholipase 0.0095 PF02038 ATP1G1/PLM/MAT8 family 0.0095 PF03630 Fumble 0.0095 PF00243 Nerve growth factor family 0.0095 PF02060 Slow voltage-gated potassium channel 0.0089 PF00027 Cyclic nucleotide-binding domain 0.0079 PF00536 SAM domain (Sterile alpha motif), 0.0079 PF01404 Ephrin receptor ligand binding domain 0.0068 PF00343 Carbohydrate phosphorylase 0.0063 PF02888 Calmodulin binding domain 0.0063 PF03530 Calcium-activated SK potassium channel 0.0062 PF08063 PADR1 (NUC008), domain 0.0062 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0062 PF00533 BRCA1 C Terminus (BRCT), domain 0.0062 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0062 PF05406 WGR domain 0.0047 PF00042 Globin 0.0047 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0035 PF01017 STAT protein, all-alpha domain 0.0035 PF02864 STAT protein, DNA binding domain 0.0035 PF02865 STAT protein, protein interaction domain 0.0034 PF01582 TIR domain 0.0034 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0034 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0034 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0034 PF00675 Insulinase (Peptidase family M16), 0.0034 PF05193 Peptidase M16 inactive domain 0.0023 PF03520 KCNQ voltage-gated potassium channel 0.0013 PF08384 Pro-opiomelanocortin, N-terminal region 0.0013 PF00976 Corticotropin ACTH domain 0.0013 PF08035 Opioids neuropeptide 0.0011 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0010 PF00576 HIUase/Transthyretin family 0.0010 PF01094 Receptor family ligand binding region 0.0008 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0007 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0005 PF01234 NNMT/PNMT/TEMT family 0.0005 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0004 PF00060 Ligand-gated ion channel 0.0004 PF00191 Annexin 0.0002 PF02743 Cache domain 0.0002 PF08399 VWA N-terminal 0.0002 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0002 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0001 PF07686 Immunoglobulin V-set domain 0.0001 PF00146 NADH dehydrogenase 0.0001 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain SUB469 O=S-C-N 0.2379 PF00690 Cation transporter/ATPase, N-terminus 0.2379 PF00689 Cation transporting ATPase, C-terminus 0.2170 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.2126 PF00122 E1-E2 ATPase 0.1931 PF00702 haloacid dehalogenase-like hydrolase 0.0524 PF00287 Sodium / potassium ATPase beta chain 0.0484 PF00091 Tubulin/FtsZ family, GTPase domain 0.0484 PF03953 Tubulin C-terminal domain 0.0374 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0369 PF00146 NADH dehydrogenase 0.0357 PF00194 Eukaryotic-type carbonic anhydrase 0.0194 PF02214 K+ channel tetramerisation domain 0.0150 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0150 PF02254 TrkA-N domain 0.0150 PF00230 Major intrinsic protein 0.0138 PF00667 FAD binding domain 0.0138 PF00258 Flavodoxin 0.0136 PF00175 Oxidoreductase NAD-binding domain 0.0135 PF00102 Protein-tyrosine phosphatase 0.0132 PF02898 Nitric oxide synthase, oxygenase domain 0.0131 PF00017 SH2 domain 0.0131 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0125 PF00018 SH3 domain 0.0120 PF12497 Estrogen receptor beta 0.0104 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0103 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0103 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0100 PF01068 ATP dependent DNA ligase domain 0.0100 PF04679 ATP dependent DNA ligase C terminal region 0.0096 PF01770 Reduced folate carrier 0.0092 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0092 PF00631 GGL domain 0.0091 PF00478 IMP dehydrogenase / GMP reductase domain 0.0088 PF08919 F-actin binding 0.0086 PF01122 Eukaryotic cobalamin-binding protein 0.0085 PF03073 TspO/MBR family 0.0083 PF00962 Adenosine/AMP deaminase 0.0080 PF02888 Calmodulin binding domain 0.0080 PF03530 Calcium-activated SK potassium channel 0.0076 PF00520 Ion transport protein 0.0070 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0064 PF01404 Ephrin receptor ligand binding domain 0.0064 PF00536 SAM domain (Sterile alpha motif), 0.0064 PF10397 Adenylosuccinate lyase C-terminus 0.0063 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0063 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0062 PF00854 POT family 0.0062 PF00273 Serum albumin family 0.0060 PF01923 Cobalamin adenosyltransferase 0.0060 PF03308 ArgK protein 0.0060 PF01642 Methylmalonyl-CoA mutase 0.0058 PF00156 Phosphoribosyl transferase domain 0.0056 PF02310 B12 binding domain 0.0055 PF01687 Riboflavin kinase 0.0053 PF00958 GMP synthase C terminal domain 0.0046 PF00794 PI3-kinase family, ras-binding domain 0.0046 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0046 PF00792 Phosphoinositide 3-kinase C2 0.0045 PF01017 STAT protein, all-alpha domain 0.0045 PF02865 STAT protein, protein interaction domain 0.0045 PF02864 STAT protein, DNA binding domain 0.0041 PF00206 Lyase 0.0034 PF00060 Ligand-gated ion channel 0.0032 PF08403 Amino acid permease N-terminal 0.0031 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0030 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0029 PF01403 Sema domain 0.0029 PF00191 Annexin 0.0029 PF01833 IPT/TIG domain 0.0029 PF02441 Flavoprotein 0.0029 PF01437 Plexin repeat 0.0028 PF00489 Interleukin-6/G-CSF/MGF family 0.0027 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0027 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0027 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0026 PF00654 Voltage gated chloride channel 0.0026 PF00571 CBS domain 0.0025 PF08377 MAP2/Tau projection domain 0.0025 PF07885 Ion channel 0.0025 PF00245 Alkaline phosphatase 0.0025 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0024 PF00970 Oxidoreductase FAD-binding domain 0.0024 PF00576 HIUase/Transthyretin family 0.0023 PF00459 Inositol monophosphatase family 0.0023 PF00069 Protein kinase domain 0.0022 PF00709 Adenylosuccinate synthetase 0.0021 PF00625 Guanylate kinase 0.0021 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0020 PF00117 Glutamine amidotransferase class-I 0.0020 PF00405 Transferrin 0.0019 PF07678 A-macroglobulin complement component 0.0019 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0019 PF07677 A-macroglobulin receptor 0.0019 PF01835 MG2 domain 0.0018 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0018 PF00533 BRCA1 C Terminus (BRCT), domain 0.0018 PF08063 PADR1 (NUC008), domain 0.0018 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0018 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0018 PF05406 WGR domain 0.0018 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0018 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0018 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0018 PF02607 B12 binding domain 0.0018 PF00809 Pterin binding enzyme 0.0017 PF02196 Raf-like Ras-binding domain 0.0017 PF01007 Inward rectifier potassium channel 0.0017 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0017 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0016 PF01180 Dihydroorotate dehydrogenase 0.0016 PF00779 BTK motif 0.0015 PF00431 CUB domain 0.0014 PF00134 Cyclin, N-terminal domain 0.0014 PF07970 Endoplasmic reticulum vesicle transporter 0.0014 PF02828 L27 domain 0.0014 PF02984 Cyclin, C-terminal domain 0.0014 PF12126 Protein of unknown function (DUF3583), 0.0014 PF01094 Receptor family ligand binding region 0.0014 PF00514 Armadillo/beta-catenin-like repeat 0.0014 PF00994 Probable molybdopterin binding domain 0.0014 PF03454 MoeA C-terminal region (domain IV), 0.0014 PF03453 MoeA N-terminal region (domain I and II), 0.0012 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0011 PF08399 VWA N-terminal 0.0011 PF00089 Trypsin 0.0011 PF02743 Cache domain 0.0011 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0010 PF00989 PAS fold 0.0010 PF00310 Glutamine amidotransferases class-II 0.0009 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0009 PF01369 Sec7 domain 0.0009 PF00303 Thymidylate synthase 0.0008 PF05193 Peptidase M16 inactive domain 0.0008 PF00675 Insulinase (Peptidase family M16), 0.0008 PF00406 Adenylate kinase 0.0007 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0007 PF00462 Glutaredoxin 0.0006 PF08763 Voltage gated calcium channel IQ domain 0.0006 PF00041 Fibronectin type III domain 0.0006 PF00042 Globin 0.0005 PF07653 Variant SH3 domain 0.0004 PF00027 Cyclic nucleotide-binding domain 0.0004 PF02189 Immunoreceptor tyrosine-based activation motif 0.0004 PF01733 Nucleoside transporter 0.0004 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0003 PF06617 M-phase inducer phosphatase 0.0003 PF03957 Jun-like transcription factor 0.0003 PF00581 Rhodanese-like domain 0.0002 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.0002 PF01426 BAH domain 0.0002 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0002 PF02525 Flavodoxin-like fold 0.0002 PF02008 CXXC zinc finger domain 0.0002 PF06464 DMAP1-binding Domain 0.0001 PF02460 Patched family 0.0001 PF03477 ATP cone domain 0.0001 PF02867 Ribonucleotide reductase, barrel domain 0.0001 PF00317 Ribonucleotide reductase, all-alpha domain 0.0001 PF00595 PDZ domain (Also known as DHR or GLGF), SUB348 C(~C)(~H)(~O)(~O) 0.2367 PF02806 Alpha amylase, C-terminal all-beta domain 0.1886 PF00128 Alpha amylase, catalytic domain 0.1840 PF03414 Glycosyltransferase family 6 0.1542 PF08070 DTHCT (NUC029), region 0.1542 PF00204 DNA gyrase B 0.1542 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0824 PF00079 Serpin (serine protease inhibitor), 0.0802 PF00059 Lectin C-type domain 0.0770 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0755 PF00167 Fibroblast growth factor 0.0719 PF00084 Sushi domain (SCR repeat), 0.0647 PF07654 Immunoglobulin C1-set domain 0.0578 PF00143 Interferon alpha/beta domain 0.0471 PF08702 Fibrinogen alpha/beta chain family 0.0471 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0420 PF02155 Glucocorticoid receptor 0.0360 PF12160 Fibrinogen alpha C domain 0.0347 PF03727 Hexokinase 0.0347 PF00349 Hexokinase 0.0334 PF00088 Trefoil (P-type), domain 0.0334 PF01055 Glycosyl hydrolases family 31 0.0330 PF01735 Lysophospholipase catalytic domain 0.0328 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0308 PF07686 Immunoglobulin V-set domain 0.0307 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0306 PF00293 NUDIX domain 0.0298 PF02065 Melibiase 0.0288 PF00337 Galactoside-binding lectin 0.0283 PF00328 Histidine acid phosphatase 0.0266 PF02267 ADP-ribosyl cyclase 0.0253 PF00690 Cation transporter/ATPase, N-terminus 0.0253 PF00689 Cation transporting ATPase, C-terminus 0.0251 PF07645 Calcium-binding EGF domain 0.0226 PF04679 ATP dependent DNA ligase C terminal region 0.0226 PF01068 ATP dependent DNA ligase domain 0.0221 PF01370 NAD dependent epimerase/dehydratase family 0.0220 PF00089 Trypsin 0.0199 PF00122 E1-E2 ATPase 0.0197 PF00041 Fibronectin type III domain 0.0169 PF00431 CUB domain 0.0167 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0140 PF00702 haloacid dehalogenase-like hydrolase 0.0112 PF00024 PAN domain 0.0108 PF01532 Glycosyl hydrolase family 47 0.0101 PF04711 Apolipoprotein A-II (ApoA-II), 0.0101 PF00031 Cystatin domain 0.0101 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0101 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0101 PF00403 Heavy-metal-associated domain 0.0091 PF00058 Low-density lipoprotein receptor repeat class B 0.0090 PF00057 Low-density lipoprotein receptor domain class A 0.0089 PF07648 Kazal-type serine protease inhibitor domain 0.0080 PF00884 Sulfatase 0.0074 PF00191 Annexin 0.0069 PF02055 O-Glycosyl hydrolase family 30 0.0069 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0067 PF03171 2OG-Fe(II), oxygenase superfamily 0.0059 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0059 PF00703 domain 0.0059 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0059 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0059 PF05735 Thrombospondin C-terminal region 0.0059 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0059 PF00236 Glycoprotein hormone 0.0059 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0059 PF01562 Reprolysin family propeptide 0.0059 PF00093 von Willebrand factor type C domain 0.0059 PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), 0.0059 PF00200 Disintegrin 0.0059 PF00021 u-PAR/Ly-6 domain 0.0059 PF01869 BadF/BadG/BcrA/BcrD ATPase family 0.0059 PF00090 Thrombospondin type 1 domain 0.0059 PF08516 ADAM cysteine-rich 0.0059 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0059 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0059 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 0.0047 PF00183 Hsp90 protein 0.0044 PF00714 Interferon gamma 0.0043 PF03781 Formylglycine-generating sulfatase enzyme 0.0040 PF10420 Cytokine interleukin-12p40 C-terminus 0.0035 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0024 PF07884 Vitamin K epoxide reductase family 0.0023 PF08718 Glycolipid transfer protein (GLTP), 0.0003 PF00176 SNF2 family N-terminal domain SUB335 C(~C)(~C)(~C)(~C) 0.2361 PF00105 Zinc finger, C4 type (two domains), 0.2360 PF00104 Ligand-binding domain of nuclear hormone receptor 0.2306 PF02159 Oestrogen receptor 0.1996 PF00191 Annexin 0.1869 PF02155 Glucocorticoid receptor 0.1635 PF02161 Progesterone receptor 0.1235 PF02166 Androgen receptor 0.0911 PF01735 Lysophospholipase catalytic domain 0.0752 PF00079 Serpin (serine protease inhibitor), 0.0649 PF08384 Pro-opiomelanocortin, N-terminal region 0.0649 PF08035 Opioids neuropeptide 0.0649 PF00976 Corticotropin ACTH domain 0.0449 PF03953 Tubulin C-terminal domain 0.0449 PF00091 Tubulin/FtsZ family, GTPase domain 0.0358 PF00168 C2 domain 0.0318 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0316 PF11825 Protein of unknown function (DUF3345), 0.0258 PF12497 Estrogen receptor beta 0.0173 PF01429 Methyl-CpG binding domain 0.0170 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0169 PF00106 short chain dehydrogenase 0.0166 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0159 PF00643 B-box zinc finger 0.0156 PF00305 Lipoxygenase 0.0150 PF07648 Kazal-type serine protease inhibitor domain 0.0140 PF08491 Squalene epoxidase 0.0137 PF00040 Fibronectin type II domain 0.0133 PF00067 Cytochrome P450 0.0129 PF06327 Domain of Unknown Function (DUF1053), 0.0123 PF02180 Bcl-2 homology region 4 0.0123 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0111 PF01122 Eukaryotic cobalamin-binding protein 0.0110 PF00918 Gastrin/cholecystokinin family 0.0109 PF00653 Inhibitor of Apoptosis domain 0.0106 PF01477 PLAT/LH2 domain 0.0099 PF04622 ERG2 and Sigma1 receptor like protein 0.0087 PF00170 bZIP transcription factor 0.0079 PF02173 pKID domain 0.0079 PF01160 Vertebrate endogenous opioids neuropeptide 0.0079 PF00212 Atrial natriuretic peptide 0.0077 PF00554 Rel homology domain (RHD), 0.0077 PF00031 Cystatin domain 0.0072 PF00650 CRAL/TRIO domain 0.0072 PF03765 CRAL/TRIO, N-terminus 0.0072 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0067 PF00656 Caspase domain 0.0067 PF01642 Methylmalonyl-CoA mutase 0.0067 PF03308 ArgK protein 0.0067 PF00762 Ferrochelatase 0.0067 PF01923 Cobalamin adenosyltransferase 0.0066 PF08377 MAP2/Tau projection domain 0.0066 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0050 PF02310 B12 binding domain 0.0049 PF00884 Sulfatase 0.0049 PF00377 Prion/Doppel alpha-helical domain 0.0047 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0045 PF00204 DNA gyrase B 0.0045 PF08070 DTHCT (NUC029), region 0.0045 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0044 PF00625 Guanylate kinase 0.0044 PF06907 Latexin 0.0044 PF03572 Peptidase family S41 0.0043 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0043 PF00969 Class II histocompatibility antigen, beta domain 0.0040 PF00183 Hsp90 protein 0.0038 PF00531 Death domain 0.0037 PF02394 Interleukin-1 propeptide 0.0037 PF00340 Interleukin-1 / 18 0.0036 PF00341 Platelet-derived growth factor (PDGF), 0.0034 PF08763 Voltage gated calcium channel IQ domain 0.0031 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0025 PF00714 Interferon gamma 0.0024 PF00489 Interleukin-6/G-CSF/MGF family 0.0022 PF00357 Integrin alpha cytoplasmic region 0.0021 PF00432 Prenyltransferase and squalene oxidase repeat 0.0021 PF03957 Jun-like transcription factor 0.0018 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0018 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0012 PF00108 Thiolase, N-terminal domain 0.0012 PF00439 Bromodomain 0.0012 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0012 PF00688 TGF-beta propeptide 0.0012 PF00019 Transforming growth factor beta like domain 0.0012 PF00890 FAD binding domain 0.0012 PF01244 Membrane dipeptidase (Peptidase family M19), 0.0012 PF01327 Polypeptide deformylase 0.0012 PF00020 TNFR/NGFR cysteine-rich region 0.0012 PF02803 Thiolase, C-terminal domain 0.0007 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0007 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0004 PF08441 Integrin alpha 0.0004 PF01425 Amidase 0.0002 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0001 PF00229 TNF(Tumour Necrosis Factor), family SUB249 >= 1 any ring size 10 0.2354 PF02159 Oestrogen receptor 0.1705 PF00105 Zinc finger, C4 type (two domains), 0.1689 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1479 PF00001 7 transmembrane receptor (rhodopsin family), 0.1443 PF00204 DNA gyrase B 0.1443 PF08070 DTHCT (NUC029), region 0.1443 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1188 PF00191 Annexin 0.1088 PF02155 Glucocorticoid receptor 0.0922 PF02161 Progesterone receptor 0.0659 PF02166 Androgen receptor 0.0605 PF01735 Lysophospholipase catalytic domain 0.0594 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0489 PF00079 Serpin (serine protease inhibitor), 0.0373 PF08384 Pro-opiomelanocortin, N-terminal region 0.0373 PF08035 Opioids neuropeptide 0.0373 PF00976 Corticotropin ACTH domain 0.0315 PF12497 Estrogen receptor beta 0.0288 PF00005 ABC transporter 0.0276 PF01401 Angiotensin-converting enzyme 0.0263 PF00664 ABC transporter transmembrane region 0.0244 PF09396 Thrombin light chain 0.0242 PF00168 C2 domain 0.0190 PF00091 Tubulin/FtsZ family, GTPase domain 0.0190 PF03953 Tubulin C-terminal domain 0.0183 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0181 PF00989 PAS fold 0.0163 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0143 PF00186 Dihydrofolate reductase 0.0139 PF07884 Vitamin K epoxide reductase family 0.0135 PF00027 Cyclic nucleotide-binding domain 0.0086 PF00042 Globin 0.0068 PF00305 Lipoxygenase 0.0067 PF11825 Protein of unknown function (DUF3345), 0.0066 PF00067 Cytochrome P450 0.0066 PF00051 Kringle domain 0.0066 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0056 PF01061 ABC-2 type transporter 0.0053 PF00643 B-box zinc finger 0.0043 PF02394 Interleukin-1 propeptide 0.0043 PF00340 Interleukin-1 / 18 0.0042 PF00229 TNF(Tumour Necrosis Factor), family 0.0040 PF07648 Kazal-type serine protease inhibitor domain 0.0039 PF04622 ERG2 and Sigma1 receptor like protein 0.0035 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0031 PF00554 Rel homology domain (RHD), 0.0029 PF06327 Domain of Unknown Function (DUF1053), 0.0029 PF01477 PLAT/LH2 domain 0.0027 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0025 PF00357 Integrin alpha cytoplasmic region 0.0023 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0021 PF08441 Integrin alpha 0.0019 PF00650 CRAL/TRIO domain 0.0019 PF03765 CRAL/TRIO, N-terminus 0.0018 PF07885 Ion channel 0.0016 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0016 PF03062 MBOAT family 0.0015 PF08771 Rapamycin binding domain 0.0015 PF02260 FATC domain 0.0015 PF02259 FAT domain 0.0011 PF00212 Atrial natriuretic peptide 0.0010 PF00341 Platelet-derived growth factor (PDGF), 0.0005 PF02180 Bcl-2 homology region 4 0.0005 PF00452 Apoptosis regulator proteins, Bcl-2 family SUB504 Cl-C:C-[#1] 0.2353 PF03073 TspO/MBR family 0.1477 PF00194 Eukaryotic-type carbonic anhydrase 0.1342 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1342 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1068 PF08403 Amino acid permease N-terminal 0.0918 PF02254 TrkA-N domain 0.0918 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0490 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0420 PF00209 Sodium:neurotransmitter symporter family 0.0395 PF00001 7 transmembrane receptor (rhodopsin family), 0.0363 PF00324 Amino acid permease 0.0339 PF00520 Ion transport protein 0.0238 PF00018 SH3 domain 0.0220 PF00069 Protein kinase domain 0.0201 PF01030 Receptor L domain 0.0201 PF00757 Furin-like cysteine rich region 0.0198 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0195 PF03098 Animal haem peroxidase 0.0195 PF00690 Cation transporter/ATPase, N-terminus 0.0195 PF00689 Cation transporting ATPase, C-terminus 0.0186 PF00017 SH2 domain 0.0184 PF00186 Dihydrofolate reductase 0.0161 PF00122 E1-E2 ATPase 0.0154 PF00305 Lipoxygenase 0.0144 PF06512 Sodium ion transport-associated 0.0144 PF00664 ABC transporter transmembrane region 0.0140 PF01477 PLAT/LH2 domain 0.0133 PF00989 PAS fold 0.0128 PF08919 F-actin binding 0.0124 PF00005 ABC transporter 0.0116 PF01007 Inward rectifier potassium channel 0.0115 PF00702 haloacid dehalogenase-like hydrolase 0.0111 PF02196 Raf-like Ras-binding domain 0.0108 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0100 PF00067 Cytochrome P450 0.0093 PF00612 IQ calmodulin-binding motif 0.0093 PF00243 Nerve growth factor family 0.0092 PF02038 ATP1G1/PLM/MAT8 family 0.0092 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0092 PF01734 Patatin-like phospholipase 0.0092 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0092 PF02060 Slow voltage-gated potassium channel 0.0092 PF03630 Fumble 0.0087 PF00027 Cyclic nucleotide-binding domain 0.0077 PF01404 Ephrin receptor ligand binding domain 0.0077 PF00536 SAM domain (Sterile alpha motif), 0.0068 PF00343 Carbohydrate phosphorylase 0.0061 PF03530 Calcium-activated SK potassium channel 0.0061 PF02888 Calmodulin binding domain 0.0060 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0060 PF05406 WGR domain 0.0060 PF00533 BRCA1 C Terminus (BRCT), domain 0.0060 PF08063 PADR1 (NUC008), domain 0.0060 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0046 PF00042 Globin 0.0046 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0034 PF01017 STAT protein, all-alpha domain 0.0034 PF02865 STAT protein, protein interaction domain 0.0034 PF02864 STAT protein, DNA binding domain 0.0033 PF05193 Peptidase M16 inactive domain 0.0033 PF01582 TIR domain 0.0033 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0033 PF00675 Insulinase (Peptidase family M16), 0.0033 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0033 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0022 PF03520 KCNQ voltage-gated potassium channel 0.0013 PF08384 Pro-opiomelanocortin, N-terminal region 0.0013 PF08035 Opioids neuropeptide 0.0013 PF00976 Corticotropin ACTH domain 0.0011 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0010 PF01094 Receptor family ligand binding region 0.0010 PF00576 HIUase/Transthyretin family 0.0007 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0007 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0005 PF01234 NNMT/PNMT/TEMT family 0.0004 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0004 PF00060 Ligand-gated ion channel 0.0004 PF00191 Annexin 0.0002 PF08399 VWA N-terminal 0.0002 PF02743 Cache domain 0.0002 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0002 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0001 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0001 PF07686 Immunoglobulin V-set domain 0.0001 PF00146 NADH dehydrogenase SUB368 C(~H)(~O)(~O) 0.2352 PF02806 Alpha amylase, C-terminal all-beta domain 0.1874 PF00128 Alpha amylase, catalytic domain 0.1829 PF03414 Glycosyltransferase family 6 0.1533 PF08070 DTHCT (NUC029), region 0.1533 PF00204 DNA gyrase B 0.1533 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0819 PF00079 Serpin (serine protease inhibitor), 0.0797 PF00059 Lectin C-type domain 0.0765 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0751 PF00167 Fibroblast growth factor 0.0715 PF00084 Sushi domain (SCR repeat), 0.0643 PF07654 Immunoglobulin C1-set domain 0.0574 PF00143 Interferon alpha/beta domain 0.0469 PF08702 Fibrinogen alpha/beta chain family 0.0469 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0417 PF02155 Glucocorticoid receptor 0.0358 PF12160 Fibrinogen alpha C domain 0.0345 PF03727 Hexokinase 0.0345 PF00349 Hexokinase 0.0332 PF01055 Glycosyl hydrolases family 31 0.0332 PF00088 Trefoil (P-type), domain 0.0328 PF01735 Lysophospholipase catalytic domain 0.0326 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0306 PF07686 Immunoglobulin V-set domain 0.0305 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0304 PF00293 NUDIX domain 0.0296 PF02065 Melibiase 0.0287 PF00337 Galactoside-binding lectin 0.0281 PF00328 Histidine acid phosphatase 0.0265 PF02267 ADP-ribosyl cyclase 0.0251 PF00690 Cation transporter/ATPase, N-terminus 0.0251 PF00689 Cation transporting ATPase, C-terminus 0.0249 PF07645 Calcium-binding EGF domain 0.0225 PF01068 ATP dependent DNA ligase domain 0.0225 PF04679 ATP dependent DNA ligase C terminal region 0.0220 PF01370 NAD dependent epimerase/dehydratase family 0.0218 PF00089 Trypsin 0.0198 PF00122 E1-E2 ATPase 0.0196 PF00041 Fibronectin type III domain 0.0168 PF00431 CUB domain 0.0165 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0140 PF00702 haloacid dehalogenase-like hydrolase 0.0111 PF00024 PAN domain 0.0107 PF01532 Glycosyl hydrolase family 47 0.0100 PF04711 Apolipoprotein A-II (ApoA-II), 0.0100 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0100 PF00403 Heavy-metal-associated domain 0.0100 PF00031 Cystatin domain 0.0100 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0090 PF00058 Low-density lipoprotein receptor repeat class B 0.0089 PF00057 Low-density lipoprotein receptor domain class A 0.0089 PF07648 Kazal-type serine protease inhibitor domain 0.0080 PF00884 Sulfatase 0.0073 PF00191 Annexin 0.0069 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0068 PF02055 O-Glycosyl hydrolase family 30 0.0067 PF03171 2OG-Fe(II), oxygenase superfamily 0.0059 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 0.0059 PF08516 ADAM cysteine-rich 0.0059 PF01869 BadF/BadG/BcrA/BcrD ATPase family 0.0059 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0059 PF00021 u-PAR/Ly-6 domain 0.0059 PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), 0.0059 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0059 PF00200 Disintegrin 0.0059 PF05735 Thrombospondin C-terminal region 0.0059 PF00703 domain 0.0059 PF01562 Reprolysin family propeptide 0.0059 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0059 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0059 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0059 PF00236 Glycoprotein hormone 0.0059 PF00093 von Willebrand factor type C domain 0.0059 PF00090 Thrombospondin type 1 domain 0.0059 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0058 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0047 PF00183 Hsp90 protein 0.0044 PF00714 Interferon gamma 0.0042 PF03781 Formylglycine-generating sulfatase enzyme 0.0039 PF10420 Cytokine interleukin-12p40 C-terminus 0.0035 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0024 PF07884 Vitamin K epoxide reductase family 0.0022 PF08718 Glycolipid transfer protein (GLTP), 0.0003 PF00176 SNF2 family N-terminal domain SUB439 C(-C)(-N)(=N) 0.2343 PF00186 Dihydrofolate reductase 0.1548 PF01048 Phosphorylase superfamily 0.1240 PF00478 IMP dehydrogenase / GMP reductase domain 0.1103 PF00069 Protein kinase domain 0.0963 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0708 PF03073 TspO/MBR family 0.0702 PF00571 CBS domain 0.0675 PF00962 Adenosine/AMP deaminase 0.0487 PF00156 Phosphoribosyl transferase domain 0.0440 PF01590 GAF domain 0.0398 PF00106 short chain dehydrogenase 0.0390 PF08240 Alcohol dehydrogenase GroES-like domain 0.0384 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0306 PF00018 SH3 domain 0.0303 PF00107 Zinc-binding dehydrogenase 0.0285 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0285 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0274 PF00017 SH2 domain 0.0274 PF08919 F-actin binding 0.0251 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0251 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0251 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0250 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0196 PF00858 Amiloride-sensitive sodium channel 0.0177 PF00171 Aldehyde dehydrogenase family 0.0175 PF09396 Thrombin light chain 0.0171 PF00757 Furin-like cysteine rich region 0.0171 PF01030 Receptor L domain 0.0161 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0154 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0154 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0143 PF01268 Formate--tetrahydrofolate ligase 0.0128 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0128 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0102 PF01687 Riboflavin kinase 0.0091 PF00821 Phosphoenolpyruvate carboxykinase 0.0076 PF00501 AMP-binding enzyme 0.0060 PF01808 AICARFT/IMPCHase bienzyme 0.0031 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0031 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0029 PF03477 ATP cone domain 0.0029 PF00317 Ribonucleotide reductase, all-alpha domain 0.0029 PF02867 Ribonucleotide reductase, barrel domain 0.0023 PF02267 ADP-ribosyl cyclase 0.0018 PF01467 Cytidylyltransferase 0.0017 PF02223 Thymidylate kinase 0.0015 PF10397 Adenylosuccinate lyase C-terminus 0.0015 PF08996 DNA Polymerase alpha zinc finger 0.0015 PF00136 DNA polymerase family B 0.0015 PF08676 MutL C terminal dimerisation domain 0.0015 PF00536 SAM domain (Sterile alpha motif), 0.0015 PF03104 DNA polymerase family B, exonuclease domain 0.0015 PF01119 DNA mismatch repair protein, C-terminal domain 0.0015 PF12473 Kinesin protein 0.0015 PF00498 FHA domain 0.0015 PF01404 Ephrin receptor ligand binding domain 0.0015 PF12423 Kinesin protein 1B 0.0014 PF01575 MaoC like domain 0.0014 PF02036 SCP-2 sterol transfer family 0.0014 PF00970 Oxidoreductase FAD-binding domain 0.0014 PF01652 Eukaryotic initiation factor 4E 0.0011 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0010 PF01122 Eukaryotic cobalamin-binding protein 0.0004 PF01230 HIT domain SUB379 C(~N)(:C)(:N) 0.2322 PF00186 Dihydrofolate reductase 0.1234 PF00069 Protein kinase domain 0.1025 PF00478 IMP dehydrogenase / GMP reductase domain 0.0894 PF08240 Alcohol dehydrogenase GroES-like domain 0.0804 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0795 PF01048 Phosphorylase superfamily 0.0789 PF00107 Zinc-binding dehydrogenase 0.0731 PF00106 short chain dehydrogenase 0.0674 PF00571 CBS domain 0.0517 PF00962 Adenosine/AMP deaminase 0.0485 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0485 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0484 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0484 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0484 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0405 PF00171 Aldehyde dehydrogenase family 0.0330 PF00018 SH3 domain 0.0320 PF00248 Aldo/keto reductase family 0.0306 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0306 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0279 PF02223 Thymidylate kinase 0.0274 PF00156 Phosphoribosyl transferase domain 0.0237 PF00017 SH2 domain 0.0232 PF00501 AMP-binding enzyme 0.0209 PF08919 F-actin binding 0.0176 PF01467 Cytidylyltransferase 0.0140 PF00225 Kinesin motor domain 0.0136 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0136 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0134 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0122 PF01230 HIT domain 0.0118 PF01119 DNA mismatch repair protein, C-terminal domain 0.0118 PF00498 FHA domain 0.0118 PF03104 DNA polymerase family B, exonuclease domain 0.0118 PF00136 DNA polymerase family B 0.0118 PF12423 Kinesin protein 1B 0.0118 PF08996 DNA Polymerase alpha zinc finger 0.0118 PF08676 MutL C terminal dimerisation domain 0.0118 PF12473 Kinesin protein 0.0117 PF00970 Oxidoreductase FAD-binding domain 0.0117 PF01575 MaoC like domain 0.0117 PF02036 SCP-2 sterol transfer family 0.0116 PF00390 Malic enzyme, N-terminal domain 0.0116 PF03949 Malic enzyme, NAD binding domain 0.0107 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0107 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0107 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0107 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0097 PF00400 WD domain, G-beta repeat 0.0097 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0097 PF00931 NB-ARC domain 0.0097 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0096 PF02233 NAD(P), transhydrogenase beta subunit 0.0079 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0076 PF00317 Ribonucleotide reductase, all-alpha domain 0.0076 PF03477 ATP cone domain 0.0076 PF02867 Ribonucleotide reductase, barrel domain 0.0075 PF03770 Inositol polyphosphate kinase 0.0074 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0069 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0062 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0062 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0035 PF00757 Furin-like cysteine rich region 0.0035 PF01030 Receptor L domain 0.0033 PF01268 Formate--tetrahydrofolate ligase 0.0033 PF00858 Amiloride-sensitive sodium channel 0.0022 PF00378 Enoyl-CoA hydratase/isomerase family 0.0022 PF00676 Dehydrogenase E1 component 0.0022 PF01064 Activin types I and II receptor domain 0.0022 PF08515 Transforming growth factor beta type I GS-motif 0.0022 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0013 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0009 PF00005 ABC transporter 0.0004 PF01126 Heme oxygenase 0.0003 PF02525 Flavodoxin-like fold SUB172 >= 5 any ring size 5 0.2317 PF01122 Eukaryotic cobalamin-binding protein 0.1714 PF02310 B12 binding domain 0.1626 PF01642 Methylmalonyl-CoA mutase 0.1626 PF03308 ArgK protein 0.1626 PF01923 Cobalamin adenosyltransferase 0.0773 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0773 PF02607 B12 binding domain 0.0773 PF00809 Pterin binding enzyme 0.0756 PF00431 CUB domain 0.0712 PF00258 Flavodoxin 0.0712 PF00667 FAD binding domain 0.0699 PF00175 Oxidoreductase NAD-binding domain 0.0496 PF07645 Calcium-binding EGF domain 0.0397 PF02574 Homocysteine S-methyltransferase 0.0219 PF02223 Thymidylate kinase 0.0201 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0181 PF08240 Alcohol dehydrogenase GroES-like domain 0.0175 PF00106 short chain dehydrogenase 0.0159 PF00107 Zinc-binding dehydrogenase 0.0157 PF00478 IMP dehydrogenase / GMP reductase domain 0.0145 PF01126 Heme oxygenase 0.0140 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0132 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0132 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0132 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0131 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0131 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0131 PF00171 Aldehyde dehydrogenase family 0.0123 PF00248 Aldo/keto reductase family 0.0123 PF02267 ADP-ribosyl cyclase 0.0123 PF00571 CBS domain 0.0113 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0113 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0097 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0092 PF01467 Cytidylyltransferase 0.0090 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0088 PF00970 Oxidoreductase FAD-binding domain 0.0080 PF01652 Eukaryotic initiation factor 4E 0.0075 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0075 PF02233 NAD(P), transhydrogenase beta subunit 0.0075 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0075 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0074 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0074 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0066 PF03770 Inositol polyphosphate kinase 0.0066 PF01575 MaoC like domain 0.0066 PF02036 SCP-2 sterol transfer family 0.0065 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0065 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0065 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0063 PF00390 Malic enzyme, N-terminal domain 0.0063 PF03949 Malic enzyme, NAD binding domain 0.0061 PF01687 Riboflavin kinase 0.0060 PF00057 Low-density lipoprotein receptor domain class A 0.0060 PF00058 Low-density lipoprotein receptor repeat class B 0.0060 PF01370 NAD dependent epimerase/dehydratase family 0.0059 PF01268 Formate--tetrahydrofolate ligase 0.0055 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0055 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0054 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0054 PF00676 Dehydrogenase E1 component 0.0053 PF02525 Flavodoxin-like fold 0.0053 PF00069 Protein kinase domain 0.0051 PF00017 SH2 domain 0.0050 PF00348 Polyprenyl synthetase 0.0049 PF00186 Dihydrofolate reductase 0.0041 PF00018 SH3 domain 0.0040 PF01230 HIT domain 0.0038 PF00378 Enoyl-CoA hydratase/isomerase family 0.0037 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0037 PF05347 Complex 1 protein (LYR family), 0.0033 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0031 PF01437 Plexin repeat 0.0031 PF01833 IPT/TIG domain 0.0031 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0031 PF01403 Sema domain 0.0031 PF02779 Transketolase, pyrimidine binding domain 0.0031 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0026 PF00501 AMP-binding enzyme 0.0025 PF12473 Kinesin protein 0.0025 PF08676 MutL C terminal dimerisation domain 0.0025 PF12423 Kinesin protein 1B 0.0025 PF01119 DNA mismatch repair protein, C-terminal domain 0.0025 PF00498 FHA domain 0.0021 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0021 PF00794 PI3-kinase family, ras-binding domain 0.0021 PF00792 Phosphoinositide 3-kinase C2 0.0020 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0020 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0018 PF00400 WD domain, G-beta repeat 0.0018 PF00931 NB-ARC domain 0.0016 PF00225 Kinesin motor domain 0.0016 PF01808 AICARFT/IMPCHase bienzyme 0.0016 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0014 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0014 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0014 PF01712 Deoxynucleoside kinase 0.0014 PF02466 Tim17/Tim22/Tim23 family 0.0014 PF00384 Molybdopterin oxidoreductase 0.0014 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0014 PF09326 Domain of unknown function (DUF1982), 0.0014 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0014 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0014 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0014 PF09166 Biliverdin reductase, catalytic 0.0014 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0014 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0014 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0014 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0014 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0014 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0014 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0014 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0014 PF10276 Zinc-finger domain 0.0014 PF08040 MNLL subunit 0.0014 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0014 PF04800 ETC complex I subunit conserved region 0.0014 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0014 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0014 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0014 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0014 PF02817 e3 binding domain 0.0014 PF10531 SLBB domain 0.0014 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0014 PF04716 ETC complex I subunit conserved region 0.0014 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0014 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0014 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0014 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0014 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0014 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0014 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0014 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0014 PF06212 GRIM-19 protein 0.0014 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0014 PF04116 Fatty acid hydroxylase superfamily 0.0010 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0010 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0008 PF02173 pKID domain 0.0008 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0007 PF00962 Adenosine/AMP deaminase 0.0006 PF03435 Saccharopine dehydrogenase 0.0006 PF02780 Transketolase, C-terminal domain 0.0006 PF00406 Adenylate kinase 0.0006 PF00042 Globin 0.0005 PF08515 Transforming growth factor beta type I GS-motif 0.0005 PF00170 bZIP transcription factor 0.0005 PF01064 Activin types I and II receptor domain 0.0001 PF00349 Hexokinase 0.0001 PF00779 BTK motif 0.0001 PF00169 PH domain 0.0001 PF03727 Hexokinase SUB525 C-C=C-C 0.2312 PF00001 7 transmembrane receptor (rhodopsin family), 0.1062 PF02159 Oestrogen receptor 0.0987 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0981 PF00105 Zinc finger, C4 type (two domains), 0.0974 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0937 PF03098 Animal haem peroxidase 0.0656 PF00209 Sodium:neurotransmitter symporter family 0.0453 PF06512 Sodium ion transport-associated 0.0449 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0449 PF08070 DTHCT (NUC029), region 0.0449 PF00204 DNA gyrase B 0.0356 PF00520 Ion transport protein 0.0274 PF03073 TspO/MBR family 0.0273 PF00191 Annexin 0.0261 PF02161 Progesterone receptor 0.0225 PF00194 Eukaryotic-type carbonic anhydrase 0.0213 PF00989 PAS fold 0.0204 PF09396 Thrombin light chain 0.0198 PF02155 Glucocorticoid receptor 0.0172 PF00027 Cyclic nucleotide-binding domain 0.0171 PF00067 Cytochrome P450 0.0126 PF01593 Flavin containing amine oxidoreductase 0.0089 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0077 PF00186 Dihydrofolate reductase 0.0074 PF01735 Lysophospholipase catalytic domain 0.0065 PF12497 Estrogen receptor beta 0.0064 PF01007 Inward rectifier potassium channel 0.0061 PF00305 Lipoxygenase 0.0049 PF00005 ABC transporter 0.0047 PF08403 Amino acid permease N-terminal 0.0036 PF00102 Protein-tyrosine phosphatase 0.0035 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0032 PF00576 HIUase/Transthyretin family 0.0022 PF00273 Serum albumin family 0.0020 PF00664 ABC transporter transmembrane region 0.0006 PF00091 Tubulin/FtsZ family, GTPase domain 0.0006 PF03953 Tubulin C-terminal domain 0.0006 PF07884 Vitamin K epoxide reductase family SUB484 N-S-C:C 0.2306 PF00194 Eukaryotic-type carbonic anhydrase 0.0842 PF08403 Amino acid permease N-terminal 0.0776 PF02254 TrkA-N domain 0.0776 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0390 PF00324 Amino acid permease 0.0230 PF00689 Cation transporting ATPase, C-terminus 0.0230 PF00690 Cation transporter/ATPase, N-terminus 0.0203 PF00122 E1-E2 ATPase 0.0177 PF00702 haloacid dehalogenase-like hydrolase 0.0161 PF00520 Ion transport protein 0.0123 PF02038 ATP1G1/PLM/MAT8 family 0.0109 PF01007 Inward rectifier potassium channel 0.0090 PF00045 Hemopexin 0.0090 PF01471 Putative peptidoglycan binding domain 0.0087 PF09396 Thrombin light chain 0.0083 PF00413 Matrixin 0.0083 PF02146 Sir2 family 0.0077 PF03953 Tubulin C-terminal domain 0.0077 PF00091 Tubulin/FtsZ family, GTPase domain 0.0072 PF00102 Protein-tyrosine phosphatase 0.0063 PF00043 Glutathione S-transferase, C-terminal domain 0.0062 PF02798 Glutathione S-transferase, N-terminal domain 0.0057 PF00001 7 transmembrane receptor (rhodopsin family), 0.0049 PF02060 Slow voltage-gated potassium channel 0.0041 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0040 PF00167 Fibroblast growth factor 0.0033 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0032 PF01590 GAF domain 0.0030 PF08983 Domain of unknown function (DUF1856), 0.0028 PF03520 KCNQ voltage-gated potassium channel 0.0028 PF00664 ABC transporter transmembrane region 0.0026 PF00108 Thiolase, N-terminal domain 0.0026 PF02803 Thiolase, C-terminal domain 0.0025 PF01916 Deoxyhypusine synthase 0.0023 PF00005 ABC transporter 0.0022 PF10420 Cytokine interleukin-12p40 C-terminus 0.0022 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0020 PF00156 Phosphoribosyl transferase domain 0.0018 PF00255 Glutathione peroxidase 0.0018 PF00478 IMP dehydrogenase / GMP reductase domain 0.0018 PF00854 POT family 0.0017 PF00962 Adenosine/AMP deaminase 0.0017 PF01770 Reduced folate carrier 0.0017 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0016 PF00051 Kringle domain 0.0016 PF01068 ATP dependent DNA ligase domain 0.0016 PF04679 ATP dependent DNA ligase C terminal region 0.0016 PF03098 Animal haem peroxidase 0.0015 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0015 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0014 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0014 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0014 PF02772 S-adenosylmethionine synthetase, central domain 0.0013 PF10397 Adenylosuccinate lyase C-terminus 0.0013 PF11857 Domain of unknown function (DUF3377), 0.0012 PF08912 Rho Binding 0.0012 PF00040 Fibronectin type II domain 0.0012 PF02185 Hr1 repeat 0.0011 PF00273 Serum albumin family 0.0010 PF12497 Estrogen receptor beta 0.0009 PF02785 Biotin carboxylase C-terminal domain 0.0009 PF01124 MAPEG family 0.0009 PF02793 Hormone receptor domain 0.0009 PF00069 Protein kinase domain 0.0009 PF00002 7 transmembrane receptor (Secretin family), 0.0008 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0008 PF04321 RmlD substrate binding domain 0.0008 PF08441 Integrin alpha 0.0008 PF00245 Alkaline phosphatase 0.0008 PF00656 Caspase domain 0.0007 PF01039 Carboxyl transferase domain 0.0007 PF08725 Integrin beta cytoplasmic domain 0.0007 PF00958 GMP synthase C terminal domain 0.0007 PF00364 Biotin-requiring enzyme 0.0007 PF01323 DSBA-like thioredoxin domain 0.0006 PF00186 Dihydrofolate reductase 0.0006 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0006 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0006 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0006 PF05649 Peptidase family M13 0.0006 PF01431 Peptidase family M13 0.0005 PF00206 Lyase 0.0005 PF03099 Biotin/lipoate A/B protein ligase family 0.0005 PF00357 Integrin alpha cytoplasmic region 0.0005 PF00230 Major intrinsic protein 0.0005 PF02574 Homocysteine S-methyltransferase 0.0004 PF00362 Integrin, beta chain 0.0004 PF00581 Rhodanese-like domain 0.0004 PF01641 SelR domain 0.0004 PF01406 tRNA synthetases class I (C), catalytic domain 0.0004 PF06617 M-phase inducer phosphatase 0.0004 PF07965 Integrin beta tail domain 0.0004 PF09334 tRNA synthetases class I (M), 0.0004 PF08326 Acetyl-CoA carboxylase, central region 0.0003 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0003 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0003 PF00474 Sodium:solute symporter family 0.0003 PF00778 DIX domain 0.0003 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0003 PF00020 TNFR/NGFR cysteine-rich region 0.0003 PF08466 Inward rectifier potassium channel N-terminal 0.0003 PF01234 NNMT/PNMT/TEMT family 0.0003 PF08833 Axin beta-catenin binding domain 0.0003 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0003 PF00112 Papain family cysteine protease 0.0003 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0003 PF04055 Radical SAM superfamily 0.0003 PF08702 Fibrinogen alpha/beta chain family 0.0003 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0002 PF00265 Thymidine kinase 0.0002 PF01731 Arylesterase 0.0002 PF01369 Sec7 domain 0.0001 PF08447 PAS fold 0.0001 PF01462 Leucine rich repeat N-terminal domain 0.0001 PF00024 PAN domain 0.0001 PF05995 Cysteine dioxygenase type I 0.0001 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0001 PF08919 F-actin binding 0.0001 PF00615 Regulator of G protein signaling domain 0.0001 PF03199 Eukaryotic glutathione synthase 0.0001 PF12160 Fibrinogen alpha C domain 0.0001 PF00058 Low-density lipoprotein receptor repeat class B 0.0001 PF03522 K-Cl Co-transporter type 1 (KCC1), SUB697 C-C-C-C-C-C-C-C 0.2286 PF00001 7 transmembrane receptor (rhodopsin family), 0.1602 PF02159 Oestrogen receptor 0.1534 PF00105 Zinc finger, C4 type (two domains), 0.1524 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0973 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0806 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0806 PF00204 DNA gyrase B 0.0806 PF08070 DTHCT (NUC029), region 0.0587 PF00209 Sodium:neurotransmitter symporter family 0.0410 PF03098 Animal haem peroxidase 0.0355 PF00191 Annexin 0.0330 PF02161 Progesterone receptor 0.0325 PF02155 Glucocorticoid receptor 0.0304 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0249 PF00091 Tubulin/FtsZ family, GTPase domain 0.0249 PF03953 Tubulin C-terminal domain 0.0247 PF00989 PAS fold 0.0237 PF00005 ABC transporter 0.0232 PF09396 Thrombin light chain 0.0221 PF02166 Androgen receptor 0.0193 PF00027 Cyclic nucleotide-binding domain 0.0186 PF00664 ABC transporter transmembrane region 0.0180 PF01735 Lysophospholipase catalytic domain 0.0157 PF00067 Cytochrome P450 0.0145 PF00079 Serpin (serine protease inhibitor), 0.0136 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0128 PF12497 Estrogen receptor beta 0.0111 PF00976 Corticotropin ACTH domain 0.0111 PF08384 Pro-opiomelanocortin, N-terminal region 0.0111 PF08035 Opioids neuropeptide 0.0082 PF01401 Angiotensin-converting enzyme 0.0072 PF00168 C2 domain 0.0056 PF00273 Serum albumin family 0.0054 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0051 PF11825 Protein of unknown function (DUF3345), 0.0049 PF01593 Flavin containing amine oxidoreductase 0.0049 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0044 PF03073 TspO/MBR family 0.0043 PF00186 Dihydrofolate reductase 0.0041 PF07884 Vitamin K epoxide reductase family 0.0026 PF00042 Globin 0.0020 PF00051 Kringle domain 0.0020 PF00305 Lipoxygenase 0.0020 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0017 PF01061 ABC-2 type transporter 0.0016 PF00643 B-box zinc finger 0.0013 PF00229 TNF(Tumour Necrosis Factor), family 0.0013 PF02394 Interleukin-1 propeptide 0.0013 PF00340 Interleukin-1 / 18 0.0012 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0012 PF07648 Kazal-type serine protease inhibitor domain 0.0012 PF04622 ERG2 and Sigma1 receptor like protein 0.0011 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0009 PF00554 Rel homology domain (RHD), 0.0009 PF01477 PLAT/LH2 domain 0.0008 PF06327 Domain of Unknown Function (DUF1053), 0.0008 PF00357 Integrin alpha cytoplasmic region 0.0006 PF00650 CRAL/TRIO domain 0.0006 PF08441 Integrin alpha 0.0006 PF03765 CRAL/TRIO, N-terminus 0.0005 PF07885 Ion channel 0.0005 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0005 PF03062 MBOAT family 0.0004 PF08771 Rapamycin binding domain 0.0004 PF02259 FAT domain 0.0004 PF02260 FATC domain 0.0003 PF06512 Sodium ion transport-associated 0.0003 PF00341 Platelet-derived growth factor (PDGF), 0.0003 PF00212 Atrial natriuretic peptide 0.0001 PF02180 Bcl-2 homology region 4 0.0001 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0001 PF00520 Ion transport protein SUB286 C-N 0.2285 PF00001 7 transmembrane receptor (rhodopsin family), 0.0600 PF03073 TspO/MBR family 0.0392 PF00209 Sodium:neurotransmitter symporter family 0.0387 PF01401 Angiotensin-converting enzyme 0.0381 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0376 PF06512 Sodium ion transport-associated 0.0361 PF00005 ABC transporter 0.0315 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0308 PF00664 ABC transporter transmembrane region 0.0240 PF00989 PAS fold 0.0222 PF01593 Flavin containing amine oxidoreductase 0.0218 PF00520 Ion transport protein 0.0213 PF00069 Protein kinase domain 0.0201 PF00186 Dihydrofolate reductase 0.0197 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0197 PF00027 Cyclic nucleotide-binding domain 0.0197 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0160 PF01048 Phosphorylase superfamily 0.0121 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0095 PF08070 DTHCT (NUC029), region 0.0095 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0095 PF00204 DNA gyrase B 0.0091 PF03953 Tubulin C-terminal domain 0.0091 PF00091 Tubulin/FtsZ family, GTPase domain 0.0069 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0069 PF02180 Bcl-2 homology region 4 0.0062 PF01061 ABC-2 type transporter 0.0061 PF08983 Domain of unknown function (DUF1856), 0.0058 PF00017 SH2 domain 0.0026 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0026 PF08491 Squalene epoxidase 0.0026 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0023 PF08919 F-actin binding 0.0021 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0016 PF00018 SH3 domain 0.0016 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0016 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0010 PF01467 Cytidylyltransferase 0.0009 PF02223 Thymidylate kinase 0.0005 PF00962 Adenosine/AMP deaminase 0.0003 PF01126 Heme oxygenase 0.0002 PF09396 Thrombin light chain 0.0001 PF00042 Globin SUB130 >= 1 any ring size 4 0.2256 PF00273 Serum albumin family 0.1825 PF12179 I-kappa-kinase-beta NEMO binding domain 0.1542 PF08534 Redoxin 0.0824 PF00854 POT family 0.0563 PF09396 Thrombin light chain 0.0382 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0382 PF02180 Bcl-2 homology region 4 0.0323 PF00069 Protein kinase domain 0.0289 PF02460 Patched family 0.0285 PF01731 Arylesterase 0.0285 PF03062 MBOAT family 0.0273 PF02984 Cyclin, C-terminal domain 0.0273 PF12126 Protein of unknown function (DUF3583), 0.0273 PF00134 Cyclin, N-terminal domain 0.0273 PF07970 Endoplasmic reticulum vesicle transporter 0.0269 PF00151 Lipase 0.0265 PF03957 Jun-like transcription factor 0.0265 PF00489 Interleukin-6/G-CSF/MGF family 0.0205 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0205 PF08702 Fibrinogen alpha/beta chain family 0.0202 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0195 PF00051 Kringle domain 0.0190 PF01401 Angiotensin-converting enzyme 0.0190 PF01431 Peptidase family M13 0.0190 PF05649 Peptidase family M13 0.0187 PF08659 KR domain 0.0187 PF00975 Thioesterase domain 0.0187 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0187 PF00698 Acyl transferase domain 0.0187 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0177 PF00170 bZIP transcription factor 0.0162 PF01477 PLAT/LH2 domain 0.0155 PF01433 Peptidase family M1 0.0147 PF00643 B-box zinc finger 0.0123 PF00690 Cation transporter/ATPase, N-terminus 0.0123 PF00689 Cation transporting ATPase, C-terminus 0.0120 PF00576 HIUase/Transthyretin family 0.0117 PF12160 Fibrinogen alpha C domain 0.0113 PF00664 ABC transporter transmembrane region 0.0109 PF00122 E1-E2 ATPase 0.0104 PF00550 Phosphopantetheine attachment site 0.0103 PF00343 Carbohydrate phosphorylase 0.0102 PF00059 Lectin C-type domain 0.0096 PF00702 haloacid dehalogenase-like hydrolase 0.0094 PF00433 Protein kinase C terminal domain 0.0091 PF00167 Fibroblast growth factor 0.0090 PF00089 Trypsin 0.0088 PF00005 ABC transporter 0.0085 PF00091 Tubulin/FtsZ family, GTPase domain 0.0085 PF03953 Tubulin C-terminal domain 0.0079 PF01459 Eukaryotic porin 0.0074 PF07645 Calcium-binding EGF domain 0.0072 PF02423 Ornithine cyclodeaminase/mu-crystallin family 0.0069 PF00079 Serpin (serine protease inhibitor), 0.0060 PF00169 PH domain 0.0053 PF00107 Zinc-binding dehydrogenase 0.0048 PF00405 Transferrin 0.0035 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0035 PF02146 Sir2 family 0.0029 PF00024 PAN domain 0.0026 PF00146 NADH dehydrogenase 0.0026 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0025 PF01161 Phosphatidylethanolamine-binding protein 0.0022 PF00459 Inositol monophosphatase family 0.0018 PF06617 M-phase inducer phosphatase 0.0018 PF00581 Rhodanese-like domain 0.0018 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0017 PF00194 Eukaryotic-type carbonic anhydrase 0.0015 PF02806 Alpha amylase, C-terminal all-beta domain 0.0015 PF03160 Calx-beta domain 0.0014 PF00324 Amino acid permease 0.0013 PF02214 K+ channel tetramerisation domain 0.0013 PF00625 Guanylate kinase 0.0012 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0012 PF00514 Armadillo/beta-catenin-like repeat 0.0012 PF00128 Alpha amylase, catalytic domain 0.0010 PF02828 L27 domain 0.0010 PF03454 MoeA C-terminal region (domain IV), 0.0010 PF03453 MoeA N-terminal region (domain I and II), 0.0010 PF00994 Probable molybdopterin binding domain 0.0010 PF00248 Aldo/keto reductase family 0.0009 PF01369 Sec7 domain 0.0009 PF00084 Sushi domain (SCR repeat), 0.0009 PF02793 Hormone receptor domain 0.0009 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0009 PF00822 PMP-22/EMP/MP20/Claudin family 0.0009 PF00002 7 transmembrane receptor (Secretin family), 0.0008 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0008 PF03477 ATP cone domain 0.0008 PF00362 Integrin, beta chain 0.0008 PF08403 Amino acid permease N-terminal 0.0008 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0008 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0008 PF00088 Trefoil (P-type), domain 0.0008 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0008 PF01055 Glycosyl hydrolases family 31 0.0008 PF02867 Ribonucleotide reductase, barrel domain 0.0008 PF07965 Integrin beta tail domain 0.0008 PF09193 Cholecystokinin A receptor, N-terminal 0.0008 PF00317 Ribonucleotide reductase, all-alpha domain 0.0007 PF00211 Adenylate and Guanylate cyclase catalytic domain 0.0007 PF01068 ATP dependent DNA ligase domain 0.0007 PF04679 ATP dependent DNA ligase C terminal region 0.0006 PF03949 Malic enzyme, NAD binding domain 0.0006 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0006 PF08240 Alcohol dehydrogenase GroES-like domain 0.0006 PF00188 Cysteine-rich secretory protein family 0.0006 PF01323 DSBA-like thioredoxin domain 0.0006 PF01370 NAD dependent epimerase/dehydratase family 0.0006 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0006 PF00041 Fibronectin type III domain 0.0006 PF00578 AhpC/TSA family 0.0006 PF00390 Malic enzyme, N-terminal domain 0.0005 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0005 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0005 PF08771 Rapamycin binding domain 0.0005 PF02743 Cache domain 0.0005 PF02260 FATC domain 0.0005 PF07653 Variant SH3 domain 0.0005 PF00328 Histidine acid phosphatase 0.0005 PF02259 FAT domain 0.0005 PF08399 VWA N-terminal 0.0005 PF00462 Glutaredoxin 0.0005 PF03414 Glycosyltransferase family 6 0.0005 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0004 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0004 PF03098 Animal haem peroxidase 0.0004 PF08763 Voltage gated calcium channel IQ domain 0.0004 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0004 PF07677 A-macroglobulin receptor 0.0004 PF07678 A-macroglobulin complement component 0.0004 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0004 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0004 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0004 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0004 PF03489 Saposin-like type B, region 2 0.0004 PF01835 MG2 domain 0.0004 PF00439 Bromodomain 0.0003 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF02233 NAD(P), transhydrogenase beta subunit 0.0003 PF01652 Eukaryotic initiation factor 4E 0.0003 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0003 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0003 PF03073 TspO/MBR family 0.0003 PF03770 Inositol polyphosphate kinase 0.0002 PF00821 Phosphoenolpyruvate carboxykinase 0.0002 PF00153 Mitochondrial carrier protein 0.0002 PF00631 GGL domain 0.0002 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0002 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0002 PF00675 Insulinase (Peptidase family M16), 0.0002 PF05193 Peptidase M16 inactive domain 0.0002 PF02267 ADP-ribosyl cyclase 0.0002 PF02803 Thiolase, C-terminal domain 0.0002 PF00431 CUB domain 0.0002 PF00106 short chain dehydrogenase 0.0002 PF00108 Thiolase, N-terminal domain 0.0002 PF00595 PDZ domain (Also known as DHR or GLGF), 0.0002 PF08983 Domain of unknown function (DUF1856), 0.0002 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0002 PF00378 Enoyl-CoA hydratase/isomerase family 0.0001 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0001 PF00406 Adenylate kinase 0.0001 PF02254 TrkA-N domain 0.0001 PF02223 Thymidylate kinase 0.0001 PF03530 Calcium-activated SK potassium channel 0.0001 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0001 PF09127 Leukotriene A4 hydrolase, C-terminal 0.0001 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0001 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0001 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0001 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0001 PF01122 Eukaryotic cobalamin-binding protein 0.0001 PF03360 Glycosyltransferase family 43 0.0001 PF00779 BTK motif 0.0001 PF00858 Amiloride-sensitive sodium channel 0.0001 PF00171 Aldehyde dehydrogenase family 0.0001 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0001 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF08674 Acetylcholinesterase tetramerisation domain 0.0001 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0001 PF02888 Calmodulin binding domain SUB32 >= 2 P 0.2224 PF02223 Thymidylate kinase 0.1808 PF00348 Polyprenyl synthetase 0.1197 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.1162 PF08240 Alcohol dehydrogenase GroES-like domain 0.1082 PF03770 Inositol polyphosphate kinase 0.0999 PF00107 Zinc-binding dehydrogenase 0.0935 PF00106 short chain dehydrogenase 0.0900 PF00102 Protein-tyrosine phosphatase 0.0895 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0884 PF02267 ADP-ribosyl cyclase 0.0755 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0755 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0751 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0751 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0751 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0736 PF01370 NAD dependent epimerase/dehydratase family 0.0640 PF00248 Aldo/keto reductase family 0.0602 PF00171 Aldehyde dehydrogenase family 0.0584 PF01467 Cytidylyltransferase 0.0451 PF00478 IMP dehydrogenase / GMP reductase domain 0.0434 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0434 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0332 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0270 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0225 PF00169 PH domain 0.0220 PF00571 CBS domain 0.0183 PF08674 Acetylcholinesterase tetramerisation domain 0.0174 PF00225 Kinesin motor domain 0.0150 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0148 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0148 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0146 PF03360 Glycosyltransferase family 43 0.0133 PF00498 FHA domain 0.0133 PF01119 DNA mismatch repair protein, C-terminal domain 0.0133 PF12473 Kinesin protein 0.0133 PF08676 MutL C terminal dimerisation domain 0.0133 PF12423 Kinesin protein 1B 0.0132 PF00501 AMP-binding enzyme 0.0125 PF00069 Protein kinase domain 0.0121 PF01575 MaoC like domain 0.0121 PF02036 SCP-2 sterol transfer family 0.0120 PF03949 Malic enzyme, NAD binding domain 0.0120 PF00390 Malic enzyme, N-terminal domain 0.0117 PF01652 Eukaryotic initiation factor 4E 0.0114 PF00970 Oxidoreductase FAD-binding domain 0.0105 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0105 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0101 PF00400 WD domain, G-beta repeat 0.0101 PF00931 NB-ARC domain 0.0099 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0099 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0084 PF02233 NAD(P), transhydrogenase beta subunit 0.0076 PF00071 Ras family 0.0074 PF00018 SH3 domain 0.0064 PF00074 Pancreatic ribonuclease 0.0035 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0029 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0029 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0017 PF03727 Hexokinase 0.0017 PF00349 Hexokinase SUB474 S-C:N:C 0.2216 PF03953 Tubulin C-terminal domain 0.2216 PF00091 Tubulin/FtsZ family, GTPase domain 0.1130 PF00690 Cation transporter/ATPase, N-terminus 0.1130 PF00689 Cation transporting ATPase, C-terminus 0.1089 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.1006 PF00122 E1-E2 ATPase 0.0908 PF00702 haloacid dehalogenase-like hydrolase 0.0356 PF00194 Eukaryotic-type carbonic anhydrase 0.0323 PF00018 SH3 domain 0.0295 PF00017 SH2 domain 0.0288 PF07884 Vitamin K epoxide reductase family 0.0277 PF01068 ATP dependent DNA ligase domain 0.0277 PF04679 ATP dependent DNA ligase C terminal region 0.0272 PF01770 Reduced folate carrier 0.0263 PF08919 F-actin binding 0.0263 PF00102 Protein-tyrosine phosphatase 0.0258 PF00287 Sodium / potassium ATPase beta chain 0.0194 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0187 PF00536 SAM domain (Sterile alpha motif), 0.0187 PF01404 Ephrin receptor ligand binding domain 0.0176 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0173 PF00146 NADH dehydrogenase 0.0155 PF00854 POT family 0.0151 PF00478 IMP dehydrogenase / GMP reductase domain 0.0130 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0129 PF02865 STAT protein, protein interaction domain 0.0129 PF01017 STAT protein, all-alpha domain 0.0129 PF02864 STAT protein, DNA binding domain 0.0128 PF00962 Adenosine/AMP deaminase 0.0102 PF00656 Caspase domain 0.0102 PF00183 Hsp90 protein 0.0101 PF02059 Interleukin-3 0.0101 PF00377 Prion/Doppel alpha-helical domain 0.0100 PF12497 Estrogen receptor beta 0.0097 PF00340 Interleukin-1 / 18 0.0097 PF02394 Interleukin-1 propeptide 0.0096 PF00156 Phosphoribosyl transferase domain 0.0095 PF10397 Adenylosuccinate lyase C-terminus 0.0091 PF02214 K+ channel tetramerisation domain 0.0087 PF00230 Major intrinsic protein 0.0083 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0083 PF02254 TrkA-N domain 0.0081 PF00958 GMP synthase C terminal domain 0.0076 PF00069 Protein kinase domain 0.0072 PF01023 S-100/ICaBP type calcium binding domain 0.0065 PF00667 FAD binding domain 0.0065 PF00258 Flavodoxin 0.0064 PF00020 TNFR/NGFR cysteine-rich region 0.0064 PF00175 Oxidoreductase NAD-binding domain 0.0064 PF03098 Animal haem peroxidase 0.0062 PF02898 Nitric oxide synthase, oxygenase domain 0.0062 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0059 PF00206 Lyase 0.0057 PF00619 Caspase recruitment domain 0.0057 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0055 PF02525 Flavodoxin-like fold 0.0054 PF00341 Platelet-derived growth factor (PDGF), 0.0052 PF00273 Serum albumin family 0.0049 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0048 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0048 PF00305 Lipoxygenase 0.0048 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0047 PF09396 Thrombin light chain 0.0046 PF00041 Fibronectin type III domain 0.0045 PF00040 Fibronectin type II domain 0.0043 PF00631 GGL domain 0.0043 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0040 PF01122 Eukaryotic cobalamin-binding protein 0.0040 PF03073 TspO/MBR family 0.0040 PF00531 Death domain 0.0038 PF02888 Calmodulin binding domain 0.0038 PF03530 Calcium-activated SK potassium channel 0.0037 PF02155 Glucocorticoid receptor 0.0036 PF00520 Ion transport protein 0.0034 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0031 PF00709 Adenylosuccinate synthetase 0.0030 PF00117 Glutamine amidotransferase class-I 0.0030 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0028 PF01923 Cobalamin adenosyltransferase 0.0028 PF01642 Methylmalonyl-CoA mutase 0.0028 PF00245 Alkaline phosphatase 0.0028 PF00571 CBS domain 0.0028 PF03308 ArgK protein 0.0026 PF00001 7 transmembrane receptor (rhodopsin family), 0.0026 PF01687 Riboflavin kinase 0.0026 PF02310 B12 binding domain 0.0022 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0022 PF00794 PI3-kinase family, ras-binding domain 0.0022 PF00792 Phosphoinositide 3-kinase C2 0.0021 PF00310 Glutamine amidotransferases class-II 0.0020 PF01477 PLAT/LH2 domain 0.0019 PF01835 MG2 domain 0.0019 PF07678 A-macroglobulin complement component 0.0019 PF07677 A-macroglobulin receptor 0.0019 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0017 PF08403 Amino acid permease N-terminal 0.0017 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0016 PF00060 Ligand-gated ion channel 0.0014 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0014 PF01403 Sema domain 0.0014 PF01833 IPT/TIG domain 0.0014 PF01437 Plexin repeat 0.0014 PF01425 Amidase 0.0014 PF02441 Flavoprotein 0.0014 PF00191 Annexin 0.0014 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0013 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0013 PF00489 Interleukin-6/G-CSF/MGF family 0.0013 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0013 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0012 PF00654 Voltage gated chloride channel 0.0012 PF08377 MAP2/Tau projection domain 0.0012 PF07885 Ion channel 0.0012 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0011 PF00970 Oxidoreductase FAD-binding domain 0.0011 PF00459 Inositol monophosphatase family 0.0011 PF00576 HIUase/Transthyretin family 0.0010 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0010 PF00625 Guanylate kinase 0.0010 PF00405 Transferrin 0.0009 PF01731 Arylesterase 0.0008 PF00809 Pterin binding enzyme 0.0008 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0008 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0008 PF05406 WGR domain 0.0008 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0008 PF08063 PADR1 (NUC008), domain 0.0008 PF01007 Inward rectifier potassium channel 0.0008 PF00533 BRCA1 C Terminus (BRCT), domain 0.0008 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0008 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0008 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0008 PF02196 Raf-like Ras-binding domain 0.0008 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0008 PF02607 B12 binding domain 0.0008 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0007 PF02828 L27 domain 0.0007 PF01180 Dihydroorotate dehydrogenase 0.0007 PF01094 Receptor family ligand binding region 0.0007 PF00994 Probable molybdopterin binding domain 0.0007 PF03453 MoeA N-terminal region (domain I and II), 0.0007 PF12126 Protein of unknown function (DUF3583), 0.0007 PF03454 MoeA C-terminal region (domain IV), 0.0007 PF00134 Cyclin, N-terminal domain 0.0007 PF07970 Endoplasmic reticulum vesicle transporter 0.0007 PF02984 Cyclin, C-terminal domain 0.0007 PF00431 CUB domain 0.0007 PF00514 Armadillo/beta-catenin-like repeat 0.0007 PF00779 BTK motif 0.0006 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0005 PF00675 Insulinase (Peptidase family M16), 0.0005 PF02743 Cache domain 0.0005 PF00989 PAS fold 0.0005 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0005 PF08399 VWA N-terminal 0.0005 PF00089 Trypsin 0.0005 PF05193 Peptidase M16 inactive domain 0.0004 PF00406 Adenylate kinase 0.0004 PF00303 Thymidylate synthase 0.0004 PF01369 Sec7 domain 0.0004 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0003 PF00462 Glutaredoxin 0.0003 PF07653 Variant SH3 domain 0.0003 PF11857 Domain of unknown function (DUF3377), 0.0003 PF00042 Globin 0.0003 PF08763 Voltage gated calcium channel IQ domain 0.0003 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0002 PF01733 Nucleoside transporter 0.0002 PF02189 Immunoreceptor tyrosine-based activation motif 0.0002 PF00027 Cyclic nucleotide-binding domain 0.0002 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0001 PF03957 Jun-like transcription factor 0.0001 PF06464 DMAP1-binding Domain 0.0001 PF02008 CXXC zinc finger domain 0.0001 PF06617 M-phase inducer phosphatase 0.0001 PF00557 Metallopeptidase family M24 0.0001 PF01426 BAH domain 0.0001 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0001 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.0001 PF02038 ATP1G1/PLM/MAT8 family 0.0001 PF00581 Rhodanese-like domain SUB454 N(-C)(=C) 0.2209 PF03073 TspO/MBR family 0.1646 PF00069 Protein kinase domain 0.1524 PF00186 Dihydrofolate reductase 0.1417 PF01048 Phosphorylase superfamily 0.1053 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0799 PF00478 IMP dehydrogenase / GMP reductase domain 0.0686 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0569 PF03953 Tubulin C-terminal domain 0.0569 PF00091 Tubulin/FtsZ family, GTPase domain 0.0564 PF00571 CBS domain 0.0491 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0491 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0430 PF00962 Adenosine/AMP deaminase 0.0375 PF01126 Heme oxygenase 0.0342 PF01590 GAF domain 0.0223 PF00156 Phosphoribosyl transferase domain 0.0222 PF08240 Alcohol dehydrogenase GroES-like domain 0.0213 PF00017 SH2 domain 0.0194 PF00042 Globin 0.0182 PF00107 Zinc-binding dehydrogenase 0.0166 PF00227 Proteasome subunit 0.0165 PF00018 SH3 domain 0.0155 PF00858 Amiloride-sensitive sodium channel 0.0140 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0135 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0100 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0100 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0095 PF00343 Carbohydrate phosphorylase 0.0085 PF02267 ADP-ribosyl cyclase 0.0074 PF00106 short chain dehydrogenase 0.0054 PF08919 F-actin binding 0.0030 PF00005 ABC transporter 0.0013 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0012 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0012 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0012 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0005 PF00171 Aldehyde dehydrogenase family 0.0005 PF01467 Cytidylyltransferase 0.0005 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0004 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0004 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0004 PF01122 Eukaryotic cobalamin-binding protein 0.0004 PF00501 AMP-binding enzyme 0.0003 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0003 PF00400 WD domain, G-beta repeat 0.0003 PF03104 DNA polymerase family B, exonuclease domain 0.0003 PF08996 DNA Polymerase alpha zinc finger 0.0003 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0003 PF00225 Kinesin motor domain 0.0003 PF01230 HIT domain 0.0003 PF02223 Thymidylate kinase 0.0003 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0003 PF00136 DNA polymerase family B 0.0003 PF00821 Phosphoenolpyruvate carboxykinase 0.0003 PF00498 FHA domain 0.0003 PF08676 MutL C terminal dimerisation domain 0.0003 PF12423 Kinesin protein 1B 0.0003 PF00970 Oxidoreductase FAD-binding domain 0.0003 PF01808 AICARFT/IMPCHase bienzyme 0.0003 PF02036 SCP-2 sterol transfer family 0.0003 PF01119 DNA mismatch repair protein, C-terminal domain 0.0003 PF00931 NB-ARC domain 0.0003 PF12473 Kinesin protein 0.0003 PF07966 A1 Propeptide 0.0003 PF02233 NAD(P), transhydrogenase beta subunit 0.0003 PF01575 MaoC like domain 0.0003 PF10397 Adenylosuccinate lyase C-terminus 0.0003 PF01652 Eukaryotic initiation factor 4E 0.0003 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0002 PF00390 Malic enzyme, N-terminal domain 0.0002 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0002 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0002 PF02525 Flavodoxin-like fold 0.0002 PF03308 ArgK protein 0.0002 PF08515 Transforming growth factor beta type I GS-motif 0.0002 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0002 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0002 PF02867 Ribonucleotide reductase, barrel domain 0.0002 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0002 PF01923 Cobalamin adenosyltransferase 0.0002 PF01642 Methylmalonyl-CoA mutase 0.0002 PF00690 Cation transporter/ATPase, N-terminus 0.0002 PF00310 Glutamine amidotransferases class-II 0.0002 PF03770 Inositol polyphosphate kinase 0.0002 PF00317 Ribonucleotide reductase, all-alpha domain 0.0002 PF00702 haloacid dehalogenase-like hydrolase 0.0002 PF01064 Activin types I and II receptor domain 0.0002 PF00676 Dehydrogenase E1 component 0.0002 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0002 PF00248 Aldo/keto reductase family 0.0002 PF03949 Malic enzyme, NAD binding domain 0.0002 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0002 PF00689 Cation transporting ATPase, C-terminus 0.0002 PF00122 E1-E2 ATPase 0.0002 PF00378 Enoyl-CoA hydratase/isomerase family 0.0002 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0002 PF00958 GMP synthase C terminal domain 0.0002 PF03477 ATP cone domain 0.0002 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0002 PF00071 Ras family 0.0001 PF11555 EGFR receptor inhibitor Mig-6 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF00536 SAM domain (Sterile alpha motif), 0.0001 PF00533 BRCA1 C Terminus (BRCT), domain 0.0001 PF03024 Folate receptor family 0.0001 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0001 PF05347 Complex 1 protein (LYR family), 0.0001 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0001 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0001 PF02779 Transketolase, pyrimidine binding domain 0.0001 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0001 PF02772 S-adenosylmethionine synthetase, central domain 0.0001 PF04679 ATP dependent DNA ligase C terminal region 0.0001 PF00183 Hsp90 protein 0.0001 PF01916 Deoxyhypusine synthase 0.0001 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0001 PF01030 Receptor L domain 0.0001 PF00334 Nucleoside diphosphate kinase 0.0001 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0001 PF01068 ATP dependent DNA ligase domain 0.0001 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0001 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0001 PF02888 Calmodulin binding domain 0.0001 PF00025 ADP-ribosylation factor family 0.0001 PF03530 Calcium-activated SK potassium channel 0.0001 PF00026 Eukaryotic aspartyl protease 0.0001 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0001 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0001 PF09027 GTPase binding 0.0001 PF00757 Furin-like cysteine rich region 0.0001 PF08063 PADR1 (NUC008), domain 0.0001 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0001 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0001 PF01268 Formate--tetrahydrofolate ligase 0.0001 PF01404 Ephrin receptor ligand binding domain 0.0001 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0001 PF05406 WGR domain 0.0001 PF01712 Deoxynucleoside kinase 0.0001 PF00206 Lyase 0.0001 PF02310 B12 binding domain 0.0001 PF00794 PI3-kinase family, ras-binding domain 0.0001 PF00792 Phosphoinositide 3-kinase C2 SUB715 Cc1ccc(O)cc1 0.2203 PF02159 Oestrogen receptor 0.1163 PF00001 7 transmembrane receptor (rhodopsin family), 0.0953 PF00105 Zinc finger, C4 type (two domains), 0.0930 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0889 PF08070 DTHCT (NUC029), region 0.0889 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0889 PF00204 DNA gyrase B 0.0444 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0431 PF12497 Estrogen receptor beta 0.0430 PF00576 HIUase/Transthyretin family 0.0346 PF08035 Opioids neuropeptide 0.0346 PF08384 Pro-opiomelanocortin, N-terminal region 0.0346 PF00976 Corticotropin ACTH domain 0.0331 PF00102 Protein-tyrosine phosphatase 0.0324 PF00989 PAS fold 0.0321 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0265 PF00027 Cyclic nucleotide-binding domain 0.0258 PF00005 ABC transporter 0.0255 PF00664 ABC transporter transmembrane region 0.0217 PF11825 Protein of unknown function (DUF3345), 0.0181 PF00643 B-box zinc finger 0.0167 PF01596 O-methyltransferase 0.0123 PF01477 PLAT/LH2 domain 0.0121 PF00305 Lipoxygenase 0.0115 PF03062 MBOAT family 0.0115 PF00340 Interleukin-1 / 18 0.0115 PF02394 Interleukin-1 propeptide 0.0097 PF08983 Domain of unknown function (DUF1856), 0.0069 PF04622 ERG2 and Sigma1 receptor like protein 0.0061 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0061 PF00656 Caspase domain 0.0060 PF01160 Vertebrate endogenous opioids neuropeptide 0.0060 PF00918 Gastrin/cholecystokinin family 0.0060 PF00183 Hsp90 protein 0.0041 PF01180 Dihydroorotate dehydrogenase 0.0041 PF01588 Putative tRNA binding domain 0.0039 PF00135 Carboxylesterase 0.0038 PF00650 CRAL/TRIO domain 0.0038 PF02180 Bcl-2 homology region 4 0.0038 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0038 PF08377 MAP2/Tau projection domain 0.0038 PF03765 CRAL/TRIO, N-terminus 0.0038 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0036 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0036 PF02460 Patched family 0.0036 PF00377 Prion/Doppel alpha-helical domain 0.0034 PF06327 Domain of Unknown Function (DUF1053), 0.0034 PF08441 Integrin alpha 0.0034 PF00884 Sulfatase 0.0031 PF00625 Guanylate kinase 0.0029 PF00357 Integrin alpha cytoplasmic region 0.0029 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0022 PF09396 Thrombin light chain 0.0022 PF07885 Ion channel 0.0018 PF00229 TNF(Tumour Necrosis Factor), family 0.0017 PF00341 Platelet-derived growth factor (PDGF), 0.0016 PF02793 Hormone receptor domain 0.0016 PF00002 7 transmembrane receptor (Secretin family), 0.0015 PF08763 Voltage gated calcium channel IQ domain 0.0014 PF00641 Zn-finger in Ran binding protein and others 0.0014 PF08742 C8 domain 0.0014 PF00094 von Willebrand factor type D domain 0.0014 PF02201 SWIB/MDM2 domain 0.0014 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0014 PF02025 Interleukin 5 0.0014 PF09193 Cholecystokinin A receptor, N-terminal 0.0013 PF00170 bZIP transcription factor 0.0012 PF00068 Phospholipase A2 0.0010 PF00757 Furin-like cysteine rich region 0.0010 PF00091 Tubulin/FtsZ family, GTPase domain 0.0010 PF03953 Tubulin C-terminal domain 0.0010 PF00266 Aminotransferase class-V 0.0010 PF01030 Receptor L domain 0.0009 PF01733 Nucleoside transporter 0.0009 PF00620 RhoGAP domain 0.0008 PF02173 pKID domain 0.0007 PF01347 Lipoprotein amino terminal region 0.0005 PF00151 Lipase SUB37 >= 8 S 0.2201 PF08702 Fibrinogen alpha/beta chain family 0.2201 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.1378 PF00273 Serum albumin family 0.1257 PF12160 Fibrinogen alpha C domain 0.1254 PF09396 Thrombin light chain 0.0955 PF00167 Fibroblast growth factor 0.0844 PF01459 Eukaryotic porin 0.0743 PF00079 Serpin (serine protease inhibitor), 0.0736 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0629 PF00051 Kringle domain 0.0609 PF00089 Trypsin 0.0376 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0372 PF02146 Sir2 family 0.0309 PF00024 PAN domain 0.0302 PF00405 Transferrin 0.0192 PF00854 POT family 0.0163 PF02806 Alpha amylase, C-terminal all-beta domain 0.0156 PF00689 Cation transporting ATPase, C-terminus 0.0156 PF00690 Cation transporter/ATPase, N-terminus 0.0149 PF00059 Lectin C-type domain 0.0138 PF00122 E1-E2 ATPase 0.0133 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0128 PF00128 Alpha amylase, catalytic domain 0.0106 PF00702 haloacid dehalogenase-like hydrolase 0.0098 PF00084 Sushi domain (SCR repeat), 0.0096 PF02793 Hormone receptor domain 0.0096 PF00002 7 transmembrane receptor (Secretin family), 0.0093 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0088 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0088 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0088 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0088 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0083 PF00088 Trefoil (P-type), domain 0.0083 PF01055 Glycosyl hydrolases family 31 0.0081 PF09193 Cholecystokinin A receptor, N-terminal 0.0077 PF04679 ATP dependent DNA ligase C terminal region 0.0077 PF01068 ATP dependent DNA ligase domain 0.0066 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0063 PF00188 Cysteine-rich secretory protein family 0.0063 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0063 PF01370 NAD dependent epimerase/dehydratase family 0.0063 PF00578 AhpC/TSA family 0.0060 PF01323 DSBA-like thioredoxin domain 0.0060 PF01731 Arylesterase 0.0058 PF03414 Glycosyltransferase family 6 0.0056 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0056 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0054 PF02259 FAT domain 0.0054 PF02260 FATC domain 0.0054 PF08771 Rapamycin binding domain 0.0050 PF02180 Bcl-2 homology region 4 0.0050 PF02460 Patched family 0.0050 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0048 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0047 PF03489 Saposin-like type B, region 2 0.0046 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0044 PF01835 MG2 domain 0.0044 PF07678 A-macroglobulin complement component 0.0044 PF07677 A-macroglobulin receptor 0.0044 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0043 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0043 PF00439 Bromodomain 0.0043 PF03062 MBOAT family 0.0040 PF06617 M-phase inducer phosphatase 0.0040 PF00581 Rhodanese-like domain 0.0036 PF03073 TspO/MBR family 0.0036 PF03770 Inositol polyphosphate kinase 0.0035 PF01652 Eukaryotic initiation factor 4E 0.0034 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0033 PF00169 PH domain 0.0030 PF03953 Tubulin C-terminal domain 0.0030 PF00091 Tubulin/FtsZ family, GTPase domain 0.0028 PF02233 NAD(P), transhydrogenase beta subunit 0.0027 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0027 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0026 PF02267 ADP-ribosyl cyclase 0.0025 PF08983 Domain of unknown function (DUF1856), 0.0022 PF00248 Aldo/keto reductase family 0.0021 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0020 PF00151 Lipase 0.0019 PF00431 CUB domain 0.0019 PF05193 Peptidase M16 inactive domain 0.0019 PF00378 Enoyl-CoA hydratase/isomerase family 0.0019 PF00675 Insulinase (Peptidase family M16), 0.0019 PF00106 short chain dehydrogenase 0.0018 PF02803 Thiolase, C-terminal domain 0.0018 PF00108 Thiolase, N-terminal domain 0.0016 PF00171 Aldehyde dehydrogenase family 0.0015 PF03360 Glycosyltransferase family 43 0.0015 PF00406 Adenylate kinase 0.0015 PF07645 Calcium-binding EGF domain 0.0013 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0013 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0013 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0012 PF00779 BTK motif 0.0011 PF01122 Eukaryotic cobalamin-binding protein 0.0010 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0010 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0008 PF01433 Peptidase family M1 0.0008 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0008 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0008 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0007 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0007 PF02223 Thymidylate kinase 0.0003 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF03308 ArgK protein 0.0002 PF08659 KR domain 0.0002 PF01923 Cobalamin adenosyltransferase 0.0002 PF00698 Acyl transferase domain 0.0002 PF01852 START domain 0.0002 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0002 PF00975 Thioesterase domain 0.0002 PF01642 Methylmalonyl-CoA mutase 0.0002 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0001 PF00583 Acetyltransferase (GNAT), family SUB672 O=C-C=C-C 0.2189 PF03098 Animal haem peroxidase 0.2183 PF00204 DNA gyrase B 0.2183 PF08070 DTHCT (NUC029), region 0.2183 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1241 PF00191 Annexin 0.1090 PF02155 Glucocorticoid receptor 0.1021 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0922 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0914 PF00105 Zinc finger, C4 type (two domains), 0.0899 PF00273 Serum albumin family 0.0781 PF00102 Protein-tyrosine phosphatase 0.0616 PF07884 Vitamin K epoxide reductase family 0.0411 PF01735 Lysophospholipase catalytic domain 0.0385 PF00005 ABC transporter 0.0366 PF06512 Sodium ion transport-associated 0.0346 PF02161 Progesterone receptor 0.0308 PF02525 Flavodoxin-like fold 0.0290 PF00576 HIUase/Transthyretin family 0.0284 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0282 PF00079 Serpin (serine protease inhibitor), 0.0278 PF01268 Formate--tetrahydrofolate ligase 0.0272 PF00464 Serine hydroxymethyltransferase 0.0270 PF02166 Androgen receptor 0.0266 PF00664 ABC transporter transmembrane region 0.0254 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0254 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0252 PF09396 Thrombin light chain 0.0217 PF00089 Trypsin 0.0217 PF00051 Kringle domain 0.0194 PF00554 Rel homology domain (RHD), 0.0184 PF05406 WGR domain 0.0184 PF08063 PADR1 (NUC008), domain 0.0184 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0184 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0184 PF00533 BRCA1 C Terminus (BRCT), domain 0.0165 PF01061 ABC-2 type transporter 0.0162 PF08403 Amino acid permease N-terminal 0.0159 PF00551 Formyl transferase 0.0148 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0143 PF11825 Protein of unknown function (DUF3345), 0.0137 PF00017 SH2 domain 0.0124 PF01571 Aminomethyltransferase folate-binding domain 0.0124 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0085 PF00018 SH3 domain 0.0082 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0082 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0082 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0072 PF02219 Methylenetetrahydrofolate reductase 0.0069 PF00531 Death domain 0.0064 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0046 PF00229 TNF(Tumour Necrosis Factor), family 0.0045 PF00183 Hsp90 protein 0.0033 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0027 PF01467 Cytidylyltransferase 0.0021 PF00343 Carbohydrate phosphorylase 0.0020 PF03024 Folate receptor family 0.0020 PF02911 Formyl transferase, C-terminal domain 0.0014 PF00248 Aldo/keto reductase family 0.0004 PF01180 Dihydroorotate dehydrogenase 0.0001 PF01596 O-methyltransferase SUB453 C(-O)(=O) 0.2188 PF03098 Animal haem peroxidase 0.1629 PF00273 Serum albumin family 0.1257 PF01401 Angiotensin-converting enzyme 0.1177 PF00204 DNA gyrase B 0.1177 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1177 PF08070 DTHCT (NUC029), region 0.0718 PF00105 Zinc finger, C4 type (two domains), 0.0711 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0603 PF00091 Tubulin/FtsZ family, GTPase domain 0.0603 PF03953 Tubulin C-terminal domain 0.0569 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0526 PF00576 HIUase/Transthyretin family 0.0522 PF00102 Protein-tyrosine phosphatase 0.0444 PF01063 Aminotransferase class IV 0.0395 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0371 PF05649 Peptidase family M13 0.0371 PF01431 Peptidase family M13 0.0322 PF11825 Protein of unknown function (DUF3345), 0.0278 PF00079 Serpin (serine protease inhibitor), 0.0250 PF00191 Annexin 0.0243 PF02798 Glutathione S-transferase, N-terminal domain 0.0234 PF00043 Glutathione S-transferase, C-terminal domain 0.0207 PF00155 Aminotransferase class I and II 0.0195 PF00202 Aminotransferase class-III 0.0163 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0163 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0134 PF00464 Serine hydroxymethyltransferase 0.0128 PF09396 Thrombin light chain 0.0099 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0080 PF00151 Lipase 0.0076 PF01268 Formate--tetrahydrofolate ligase 0.0072 PF00822 PMP-22/EMP/MP20/Claudin family 0.0072 PF00024 PAN domain 0.0069 PF00733 Asparagine synthase 0.0053 PF02155 Glucocorticoid receptor 0.0049 PF02574 Homocysteine S-methyltransferase 0.0046 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0046 PF00375 Sodium:dicarboxylate symporter family 0.0044 PF01126 Heme oxygenase 0.0041 PF01490 Transmembrane amino acid transporter protein 0.0037 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0037 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0037 PF00764 Arginosuccinate synthase 0.0037 PF00039 Fibronectin type I domain 0.0037 PF00490 Delta-aminolevulinic acid dehydratase 0.0030 PF00255 Glutathione peroxidase 0.0025 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0023 PF00458 WHEP-TRS domain 0.0018 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0018 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0018 PF07706 Aminotransferase ubiquitination site 0.0018 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0017 PF07648 Kazal-type serine protease inhibitor domain 0.0013 PF04960 Glutaminase 0.0004 PF00854 POT family 0.0001 PF12549 Tyrosine hydroxylase N terminal SUB622 N-C:C:C:N 0.2187 PF00186 Dihydrofolate reductase 0.1162 PF00069 Protein kinase domain 0.0965 PF00478 IMP dehydrogenase / GMP reductase domain 0.0842 PF08240 Alcohol dehydrogenase GroES-like domain 0.0757 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0749 PF01048 Phosphorylase superfamily 0.0743 PF00107 Zinc-binding dehydrogenase 0.0688 PF00106 short chain dehydrogenase 0.0635 PF00571 CBS domain 0.0487 PF00962 Adenosine/AMP deaminase 0.0456 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0456 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0455 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0455 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0455 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0382 PF00171 Aldehyde dehydrogenase family 0.0311 PF00018 SH3 domain 0.0302 PF00248 Aldo/keto reductase family 0.0288 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0288 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0263 PF02223 Thymidylate kinase 0.0258 PF00156 Phosphoribosyl transferase domain 0.0224 PF00017 SH2 domain 0.0218 PF00501 AMP-binding enzyme 0.0196 PF08919 F-actin binding 0.0166 PF01467 Cytidylyltransferase 0.0132 PF00225 Kinesin motor domain 0.0128 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0128 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0126 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0114 PF01230 HIT domain 0.0111 PF08676 MutL C terminal dimerisation domain 0.0111 PF12473 Kinesin protein 0.0111 PF00498 FHA domain 0.0111 PF08996 DNA Polymerase alpha zinc finger 0.0111 PF03104 DNA polymerase family B, exonuclease domain 0.0111 PF00136 DNA polymerase family B 0.0111 PF01119 DNA mismatch repair protein, C-terminal domain 0.0111 PF01575 MaoC like domain 0.0111 PF02036 SCP-2 sterol transfer family 0.0111 PF12423 Kinesin protein 1B 0.0110 PF00970 Oxidoreductase FAD-binding domain 0.0109 PF03949 Malic enzyme, NAD binding domain 0.0109 PF00390 Malic enzyme, N-terminal domain 0.0100 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0100 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0100 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0100 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0091 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0091 PF00931 NB-ARC domain 0.0091 PF02233 NAD(P), transhydrogenase beta subunit 0.0091 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0091 PF00400 WD domain, G-beta repeat 0.0074 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0071 PF00317 Ribonucleotide reductase, all-alpha domain 0.0071 PF02867 Ribonucleotide reductase, barrel domain 0.0071 PF03477 ATP cone domain 0.0071 PF03770 Inositol polyphosphate kinase 0.0070 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0065 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0058 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0058 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0033 PF00757 Furin-like cysteine rich region 0.0033 PF01030 Receptor L domain 0.0031 PF01268 Formate--tetrahydrofolate ligase 0.0031 PF00858 Amiloride-sensitive sodium channel 0.0021 PF00378 Enoyl-CoA hydratase/isomerase family 0.0021 PF00676 Dehydrogenase E1 component 0.0021 PF01064 Activin types I and II receptor domain 0.0021 PF08515 Transforming growth factor beta type I GS-motif 0.0021 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0012 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0009 PF00005 ABC transporter 0.0004 PF01126 Heme oxygenase 0.0002 PF02525 Flavodoxin-like fold SUB739 Cc1cc(Cl)ccc1 0.2186 PF03073 TspO/MBR family 0.1975 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1975 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0217 PF00343 Carbohydrate phosphorylase 0.0198 PF08403 Amino acid permease N-terminal 0.0189 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0178 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0178 PF02254 TrkA-N domain 0.0175 PF00989 PAS fold 0.0146 PF02196 Raf-like Ras-binding domain 0.0143 PF00194 Eukaryotic-type carbonic anhydrase 0.0138 PF00027 Cyclic nucleotide-binding domain 0.0132 PF00209 Sodium:neurotransmitter symporter family 0.0123 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0121 PF00001 7 transmembrane receptor (rhodopsin family), 0.0120 PF00018 SH3 domain 0.0119 PF00186 Dihydrofolate reductase 0.0111 PF00520 Ion transport protein 0.0105 PF00017 SH2 domain 0.0097 PF01007 Inward rectifier potassium channel 0.0096 PF06512 Sodium ion transport-associated 0.0085 PF08919 F-actin binding 0.0069 PF00612 IQ calmodulin-binding motif 0.0069 PF00243 Nerve growth factor family 0.0066 PF00664 ABC transporter transmembrane region 0.0064 PF00690 Cation transporter/ATPase, N-terminus 0.0064 PF00689 Cation transporting ATPase, C-terminus 0.0062 PF00536 SAM domain (Sterile alpha motif), 0.0062 PF01404 Ephrin receptor ligand binding domain 0.0060 PF00005 ABC transporter 0.0058 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0053 PF00122 E1-E2 ATPase 0.0047 PF00324 Amino acid permease 0.0042 PF02865 STAT protein, protein interaction domain 0.0042 PF02864 STAT protein, DNA binding domain 0.0042 PF01017 STAT protein, all-alpha domain 0.0037 PF01234 NNMT/PNMT/TEMT family 0.0036 PF00702 haloacid dehalogenase-like hydrolase 0.0034 PF00069 Protein kinase domain 0.0033 PF00191 Annexin 0.0017 PF08399 VWA N-terminal 0.0017 PF02743 Cache domain 0.0017 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0017 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0012 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0011 PF03530 Calcium-activated SK potassium channel 0.0011 PF02888 Calmodulin binding domain 0.0010 PF03630 Fumble 0.0010 PF02038 ATP1G1/PLM/MAT8 family 0.0010 PF07686 Immunoglobulin V-set domain 0.0010 PF02060 Slow voltage-gated potassium channel 0.0010 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0010 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0010 PF01734 Patatin-like phospholipase 0.0005 PF03520 KCNQ voltage-gated potassium channel 0.0005 PF00146 NADH dehydrogenase 0.0004 PF00858 Amiloride-sensitive sodium channel 0.0001 PF01437 Plexin repeat 0.0001 PF02758 PAAD/DAPIN/Pyrin domain 0.0001 PF00757 Furin-like cysteine rich region 0.0001 PF00717 Peptidase S24-like 0.0001 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0001 PF11956 Ankyrin-G binding motif of KCNQ2-3 0.0001 PF00631 GGL domain 0.0001 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0001 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0001 PF08912 Rho Binding 0.0001 PF01403 Sema domain 0.0001 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 0.0001 PF01833 IPT/TIG domain 0.0001 PF02185 Hr1 repeat 0.0001 PF08377 MAP2/Tau projection domain 0.0001 PF01030 Receptor L domain SUB841 CC1CC(O)CC1 0.2184 PF02159 Oestrogen receptor 0.1853 PF02155 Glucocorticoid receptor 0.1850 PF00191 Annexin 0.1612 PF00105 Zinc finger, C4 type (two domains), 0.1608 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1582 PF02161 Progesterone receptor 0.1210 PF02166 Androgen receptor 0.0867 PF01735 Lysophospholipase catalytic domain 0.0719 PF00079 Serpin (serine protease inhibitor), 0.0346 PF00168 C2 domain 0.0275 PF12497 Estrogen receptor beta 0.0224 PF00976 Corticotropin ACTH domain 0.0224 PF08035 Opioids neuropeptide 0.0224 PF08384 Pro-opiomelanocortin, N-terminal region 0.0180 PF00690 Cation transporter/ATPase, N-terminus 0.0180 PF00689 Cation transporting ATPase, C-terminus 0.0160 PF00122 E1-E2 ATPase 0.0135 PF00702 haloacid dehalogenase-like hydrolase 0.0121 PF07648 Kazal-type serine protease inhibitor domain 0.0120 PF00554 Rel homology domain (RHD), 0.0120 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0118 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0117 PF00031 Cystatin domain 0.0111 PF00212 Atrial natriuretic peptide 0.0101 PF08377 MAP2/Tau projection domain 0.0101 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0087 PF00067 Cytochrome P450 0.0084 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0081 PF00704 Glycosyl hydrolases family 18 0.0081 PF01607 Chitin binding Peritrophin-A domain 0.0077 PF00039 Fibronectin type I domain 0.0069 PF02898 Nitric oxide synthase, oxygenase domain 0.0062 PF00106 short chain dehydrogenase 0.0061 PF00531 Death domain 0.0060 PF00762 Ferrochelatase 0.0052 PF09164 Vitamin D binding protein, domain III 0.0052 PF00654 Voltage gated chloride channel 0.0050 PF02180 Bcl-2 homology region 4 0.0050 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0041 PF00667 FAD binding domain 0.0041 PF00258 Flavodoxin 0.0041 PF00305 Lipoxygenase 0.0036 PF00884 Sulfatase 0.0036 PF02038 ATP1G1/PLM/MAT8 family 0.0034 PF00175 Oxidoreductase NAD-binding domain 0.0033 PF00432 Prenyltransferase and squalene oxidase repeat 0.0032 PF07884 Vitamin K epoxide reductase family 0.0022 PF00023 Ankyrin repeat 0.0016 PF00341 Platelet-derived growth factor (PDGF), 0.0015 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0015 PF00969 Class II histocompatibility antigen, beta domain 0.0015 PF01477 PLAT/LH2 domain 0.0014 PF04756 OST3 / OST6 family 0.0014 PF02210 Laminin G domain 0.0014 PF00377 Prion/Doppel alpha-helical domain 0.0014 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0014 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0012 PF01593 Flavin containing amine oxidoreductase 0.0008 PF00688 TGF-beta propeptide 0.0008 PF00020 TNFR/NGFR cysteine-rich region 0.0008 PF01429 Methyl-CpG binding domain 0.0008 PF00019 Transforming growth factor beta like domain 0.0007 PF05193 Peptidase M16 inactive domain 0.0007 PF00675 Insulinase (Peptidase family M16), 0.0007 PF00714 Interferon gamma 0.0006 PF02394 Interleukin-1 propeptide 0.0006 PF00340 Interleukin-1 / 18 0.0004 PF01431 Peptidase family M13 0.0004 PF05649 Peptidase family M13 0.0003 PF00656 Caspase domain 0.0002 PF01391 Collagen triple helix repeat (20 copies), SUB862 CC1C(O)CCC1 0.2184 PF02159 Oestrogen receptor 0.1853 PF02155 Glucocorticoid receptor 0.1850 PF00191 Annexin 0.1612 PF00105 Zinc finger, C4 type (two domains), 0.1608 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1582 PF02161 Progesterone receptor 0.1210 PF02166 Androgen receptor 0.0867 PF01735 Lysophospholipase catalytic domain 0.0719 PF00079 Serpin (serine protease inhibitor), 0.0346 PF00168 C2 domain 0.0275 PF12497 Estrogen receptor beta 0.0224 PF08035 Opioids neuropeptide 0.0224 PF00976 Corticotropin ACTH domain 0.0224 PF08384 Pro-opiomelanocortin, N-terminal region 0.0180 PF00690 Cation transporter/ATPase, N-terminus 0.0180 PF00689 Cation transporting ATPase, C-terminus 0.0160 PF00122 E1-E2 ATPase 0.0135 PF00702 haloacid dehalogenase-like hydrolase 0.0121 PF07648 Kazal-type serine protease inhibitor domain 0.0120 PF00554 Rel homology domain (RHD), 0.0120 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0118 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0117 PF00031 Cystatin domain 0.0111 PF00212 Atrial natriuretic peptide 0.0101 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0101 PF08377 MAP2/Tau projection domain 0.0087 PF00067 Cytochrome P450 0.0084 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0081 PF01607 Chitin binding Peritrophin-A domain 0.0081 PF00704 Glycosyl hydrolases family 18 0.0077 PF00039 Fibronectin type I domain 0.0069 PF02898 Nitric oxide synthase, oxygenase domain 0.0062 PF00106 short chain dehydrogenase 0.0061 PF00531 Death domain 0.0060 PF00762 Ferrochelatase 0.0052 PF09164 Vitamin D binding protein, domain III 0.0052 PF00654 Voltage gated chloride channel 0.0050 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0050 PF02180 Bcl-2 homology region 4 0.0041 PF00667 FAD binding domain 0.0041 PF00305 Lipoxygenase 0.0041 PF00258 Flavodoxin 0.0036 PF00884 Sulfatase 0.0036 PF02038 ATP1G1/PLM/MAT8 family 0.0034 PF00175 Oxidoreductase NAD-binding domain 0.0033 PF00432 Prenyltransferase and squalene oxidase repeat 0.0032 PF07884 Vitamin K epoxide reductase family 0.0022 PF00023 Ankyrin repeat 0.0016 PF00341 Platelet-derived growth factor (PDGF), 0.0015 PF00969 Class II histocompatibility antigen, beta domain 0.0015 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0015 PF01477 PLAT/LH2 domain 0.0014 PF04756 OST3 / OST6 family 0.0014 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0014 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0014 PF00377 Prion/Doppel alpha-helical domain 0.0014 PF02210 Laminin G domain 0.0012 PF01593 Flavin containing amine oxidoreductase 0.0008 PF00019 Transforming growth factor beta like domain 0.0008 PF01429 Methyl-CpG binding domain 0.0008 PF00020 TNFR/NGFR cysteine-rich region 0.0008 PF00688 TGF-beta propeptide 0.0007 PF00714 Interferon gamma 0.0007 PF05193 Peptidase M16 inactive domain 0.0007 PF00675 Insulinase (Peptidase family M16), 0.0006 PF02394 Interleukin-1 propeptide 0.0006 PF00340 Interleukin-1 / 18 0.0004 PF01431 Peptidase family M13 0.0004 PF05649 Peptidase family M13 0.0003 PF00656 Caspase domain 0.0002 PF01391 Collagen triple helix repeat (20 copies), SUB15 >= 1 N 0.2168 PF00001 7 transmembrane receptor (rhodopsin family), 0.0569 PF03073 TspO/MBR family 0.0372 PF00209 Sodium:neurotransmitter symporter family 0.0367 PF01401 Angiotensin-converting enzyme 0.0361 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0357 PF06512 Sodium ion transport-associated 0.0343 PF00005 ABC transporter 0.0299 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0293 PF00664 ABC transporter transmembrane region 0.0228 PF00989 PAS fold 0.0210 PF01593 Flavin containing amine oxidoreductase 0.0207 PF00520 Ion transport protein 0.0202 PF00069 Protein kinase domain 0.0190 PF00186 Dihydrofolate reductase 0.0187 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0187 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0187 PF00027 Cyclic nucleotide-binding domain 0.0152 PF01048 Phosphorylase superfamily 0.0115 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0090 PF00204 DNA gyrase B 0.0090 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0090 PF08070 DTHCT (NUC029), region 0.0086 PF03953 Tubulin C-terminal domain 0.0086 PF00091 Tubulin/FtsZ family, GTPase domain 0.0066 PF02180 Bcl-2 homology region 4 0.0066 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0059 PF01061 ABC-2 type transporter 0.0058 PF08983 Domain of unknown function (DUF1856), 0.0055 PF00017 SH2 domain 0.0025 PF08491 Squalene epoxidase 0.0024 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0024 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0022 PF08919 F-actin binding 0.0020 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0015 PF00018 SH3 domain 0.0015 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0015 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0009 PF02223 Thymidylate kinase 0.0009 PF01467 Cytidylyltransferase 0.0005 PF00962 Adenosine/AMP deaminase 0.0003 PF01126 Heme oxygenase 0.0002 PF09396 Thrombin light chain 0.0001 PF00042 Globin SUB346 C(~C)(~H)(~N) 0.2168 PF00001 7 transmembrane receptor (rhodopsin family), 0.0865 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0715 PF00209 Sodium:neurotransmitter symporter family 0.0514 PF03073 TspO/MBR family 0.0422 PF01401 Angiotensin-converting enzyme 0.0306 PF00005 ABC transporter 0.0264 PF00664 ABC transporter transmembrane region 0.0251 PF00989 PAS fold 0.0222 PF00186 Dihydrofolate reductase 0.0212 PF00027 Cyclic nucleotide-binding domain 0.0208 PF02223 Thymidylate kinase 0.0178 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0172 PF01048 Phosphorylase superfamily 0.0145 PF00069 Protein kinase domain 0.0139 PF06512 Sodium ion transport-associated 0.0128 PF01431 Peptidase family M13 0.0128 PF05649 Peptidase family M13 0.0108 PF00520 Ion transport protein 0.0099 PF00017 SH2 domain 0.0096 PF02180 Bcl-2 homology region 4 0.0096 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0088 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0088 PF08983 Domain of unknown function (DUF1856), 0.0088 PF02267 ADP-ribosyl cyclase 0.0077 PF01007 Inward rectifier potassium channel 0.0055 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0051 PF01842 ACT domain 0.0050 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0049 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0048 PF00464 Serine hydroxymethyltransferase 0.0042 PF01061 ABC-2 type transporter 0.0040 PF01467 Cytidylyltransferase 0.0040 PF00018 SH3 domain 0.0039 PF00255 Glutathione peroxidase 0.0038 PF00303 Thymidylate synthase 0.0038 PF02798 Glutathione S-transferase, N-terminal domain 0.0035 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0035 PF01234 NNMT/PNMT/TEMT family 0.0035 PF08919 F-actin binding 0.0035 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0030 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0030 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0030 PF00043 Glutathione S-transferase, C-terminal domain 0.0024 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0021 PF01590 GAF domain 0.0020 PF00551 Formyl transferase 0.0020 PF03807 NADP oxidoreductase coenzyme F420-dependent 0.0017 PF08491 Squalene epoxidase 0.0012 PF08441 Integrin alpha 0.0012 PF00088 Trefoil (P-type), domain 0.0012 PF01055 Glycosyl hydrolases family 31 0.0010 PF09396 Thrombin light chain 0.0010 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0009 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0009 PF02173 pKID domain 0.0009 PF05406 WGR domain 0.0009 PF00533 BRCA1 C Terminus (BRCT), domain 0.0009 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0009 PF08063 PADR1 (NUC008), domain 0.0009 PF01808 AICARFT/IMPCHase bienzyme 0.0009 PF07966 A1 Propeptide 0.0009 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0009 PF01687 Riboflavin kinase 0.0007 PF08403 Amino acid permease N-terminal 0.0006 PF01122 Eukaryotic cobalamin-binding protein 0.0006 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0006 PF00357 Integrin alpha cytoplasmic region 0.0006 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0006 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0006 PF01426 BAH domain 0.0006 PF01571 Aminomethyltransferase folate-binding domain 0.0006 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0006 PF02008 CXXC zinc finger domain 0.0006 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0006 PF00026 Eukaryotic aspartyl protease 0.0006 PF06464 DMAP1-binding Domain 0.0003 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0003 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0002 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0002 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF00204 DNA gyrase B 0.0002 PF08070 DTHCT (NUC029), region 0.0001 PF00755 Choline/Carnitine o-acyltransferase SUB381 C(~O)(~O) 0.2154 PF03098 Animal haem peroxidase 0.1605 PF00273 Serum albumin family 0.1237 PF01401 Angiotensin-converting enzyme 0.1229 PF08070 DTHCT (NUC029), region 0.1229 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1229 PF00204 DNA gyrase B 0.0708 PF00105 Zinc finger, C4 type (two domains), 0.0702 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0594 PF03953 Tubulin C-terminal domain 0.0594 PF00091 Tubulin/FtsZ family, GTPase domain 0.0562 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0519 PF00576 HIUase/Transthyretin family 0.0515 PF00102 Protein-tyrosine phosphatase 0.0438 PF01063 Aminotransferase class IV 0.0424 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0365 PF01431 Peptidase family M13 0.0365 PF05649 Peptidase family M13 0.0316 PF11825 Protein of unknown function (DUF3345), 0.0312 PF00079 Serpin (serine protease inhibitor), 0.0252 PF00191 Annexin 0.0239 PF02798 Glutathione S-transferase, N-terminal domain 0.0230 PF00043 Glutathione S-transferase, C-terminal domain 0.0205 PF00155 Aminotransferase class I and II 0.0193 PF00202 Aminotransferase class-III 0.0160 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0160 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0132 PF00464 Serine hydroxymethyltransferase 0.0126 PF09396 Thrombin light chain 0.0106 PF02806 Alpha amylase, C-terminal all-beta domain 0.0097 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0084 PF00128 Alpha amylase, catalytic domain 0.0082 PF03414 Glycosyltransferase family 6 0.0078 PF00151 Lipase 0.0075 PF00024 PAN domain 0.0075 PF01268 Formate--tetrahydrofolate ligase 0.0074 PF02155 Glucocorticoid receptor 0.0071 PF00822 PMP-22/EMP/MP20/Claudin family 0.0068 PF00733 Asparagine synthase 0.0048 PF02574 Homocysteine S-methyltransferase 0.0046 PF00375 Sodium:dicarboxylate symporter family 0.0046 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0043 PF01126 Heme oxygenase 0.0041 PF01490 Transmembrane amino acid transporter protein 0.0037 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0037 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0036 PF00490 Delta-aminolevulinic acid dehydratase 0.0036 PF00059 Lectin C-type domain 0.0036 PF00764 Arginosuccinate synthase 0.0036 PF00039 Fibronectin type I domain 0.0034 PF00167 Fibroblast growth factor 0.0032 PF00084 Sushi domain (SCR repeat), 0.0029 PF07654 Immunoglobulin C1-set domain 0.0029 PF00255 Glutathione peroxidase 0.0026 PF00143 Interferon alpha/beta domain 0.0025 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0023 PF00458 WHEP-TRS domain 0.0021 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0021 PF08702 Fibrinogen alpha/beta chain family 0.0020 PF07648 Kazal-type serine protease inhibitor domain 0.0018 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0018 PF07706 Aminotransferase ubiquitination site 0.0018 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0018 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0016 PF12160 Fibrinogen alpha C domain 0.0015 PF03727 Hexokinase 0.0015 PF00088 Trefoil (P-type), domain 0.0015 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0015 PF01735 Lysophospholipase catalytic domain 0.0015 PF00349 Hexokinase 0.0015 PF01055 Glycosyl hydrolases family 31 0.0014 PF07686 Immunoglobulin V-set domain 0.0014 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0014 PF00293 NUDIX domain 0.0013 PF00328 Histidine acid phosphatase 0.0013 PF02065 Melibiase 0.0013 PF00337 Galactoside-binding lectin 0.0012 PF04960 Glutaminase 0.0012 PF02267 ADP-ribosyl cyclase 0.0011 PF00690 Cation transporter/ATPase, N-terminus 0.0011 PF00689 Cation transporting ATPase, C-terminus 0.0011 PF07645 Calcium-binding EGF domain 0.0010 PF04679 ATP dependent DNA ligase C terminal region 0.0010 PF00089 Trypsin 0.0010 PF01370 NAD dependent epimerase/dehydratase family 0.0010 PF01068 ATP dependent DNA ligase domain 0.0009 PF00122 E1-E2 ATPase 0.0009 PF00041 Fibronectin type III domain 0.0008 PF00431 CUB domain 0.0007 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0006 PF00702 haloacid dehalogenase-like hydrolase 0.0005 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0005 PF04711 Apolipoprotein A-II (ApoA-II), 0.0005 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0005 PF01532 Glycosyl hydrolase family 47 0.0005 PF00031 Cystatin domain 0.0005 PF00403 Heavy-metal-associated domain 0.0004 PF00854 POT family 0.0004 PF00057 Low-density lipoprotein receptor domain class A 0.0004 PF00058 Low-density lipoprotein receptor repeat class B 0.0004 PF00884 Sulfatase 0.0003 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 0.0003 PF01562 Reprolysin family propeptide 0.0003 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0003 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0003 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0003 PF00200 Disintegrin 0.0003 PF00090 Thrombospondin type 1 domain 0.0003 PF02055 O-Glycosyl hydrolase family 30 0.0003 PF00093 von Willebrand factor type C domain 0.0003 PF08516 ADAM cysteine-rich 0.0003 PF00236 Glycoprotein hormone 0.0003 PF00021 u-PAR/Ly-6 domain 0.0003 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0003 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0003 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0003 PF03171 2OG-Fe(II), oxygenase superfamily 0.0003 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0003 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0003 PF01869 BadF/BadG/BcrA/BcrD ATPase family 0.0003 PF00703 domain 0.0003 PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), 0.0003 PF05735 Thrombospondin C-terminal region 0.0002 PF10420 Cytokine interleukin-12p40 C-terminus 0.0002 PF00714 Interferon gamma 0.0002 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0002 PF03781 Formylglycine-generating sulfatase enzyme 0.0002 PF00183 Hsp90 protein 0.0001 PF00557 Metallopeptidase family M24 0.0001 PF02166 Androgen receptor 0.0001 PF02159 Oestrogen receptor 0.0001 PF01842 ACT domain 0.0001 PF00303 Thymidylate synthase 0.0001 PF08718 Glycolipid transfer protein (GLTP), 0.0001 PF07884 Vitamin K epoxide reductase family 0.0001 PF12549 Tyrosine hydroxylase N terminal SUB550 N-C-C:C 0.2125 PF03073 TspO/MBR family 0.2117 PF00194 Eukaryotic-type carbonic anhydrase 0.1646 PF00186 Dihydrofolate reductase 0.1187 PF00069 Protein kinase domain 0.0914 PF01048 Phosphorylase superfamily 0.0864 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0857 PF00001 7 transmembrane receptor (rhodopsin family), 0.0821 PF08403 Amino acid permease N-terminal 0.0728 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0728 PF08070 DTHCT (NUC029), region 0.0728 PF00204 DNA gyrase B 0.0625 PF06512 Sodium ion transport-associated 0.0499 PF02254 TrkA-N domain 0.0499 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0424 PF00005 ABC transporter 0.0399 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0321 PF00478 IMP dehydrogenase / GMP reductase domain 0.0290 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0283 PF01126 Heme oxygenase 0.0245 PF00962 Adenosine/AMP deaminase 0.0224 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0223 PF01061 ABC-2 type transporter 0.0216 PF00017 SH2 domain 0.0206 PF00520 Ion transport protein 0.0195 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0195 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0188 PF00018 SH3 domain 0.0177 PF01590 GAF domain 0.0165 PF00664 ABC transporter transmembrane region 0.0138 PF00571 CBS domain 0.0133 PF00042 Globin 0.0115 PF00102 Protein-tyrosine phosphatase 0.0109 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0109 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0091 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0076 PF00156 Phosphoribosyl transferase domain 0.0069 PF00464 Serine hydroxymethyltransferase 0.0056 PF08919 F-actin binding 0.0051 PF00858 Amiloride-sensitive sodium channel 0.0046 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0046 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0044 PF01268 Formate--tetrahydrofolate ligase 0.0034 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB571 C:C-C-C 0.2118 PF00001 7 transmembrane receptor (rhodopsin family), 0.0971 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0708 PF00209 Sodium:neurotransmitter symporter family 0.0643 PF03098 Animal haem peroxidase 0.0587 PF00194 Eukaryotic-type carbonic anhydrase 0.0514 PF08070 DTHCT (NUC029), region 0.0514 PF00204 DNA gyrase B 0.0514 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0476 PF06512 Sodium ion transport-associated 0.0427 PF00520 Ion transport protein 0.0403 PF03073 TspO/MBR family 0.0250 PF00989 PAS fold 0.0208 PF00027 Cyclic nucleotide-binding domain 0.0206 PF09396 Thrombin light chain 0.0183 PF00102 Protein-tyrosine phosphatase 0.0179 PF00186 Dihydrofolate reductase 0.0161 PF01593 Flavin containing amine oxidoreductase 0.0155 PF00576 HIUase/Transthyretin family 0.0142 PF08403 Amino acid permease N-terminal 0.0128 PF01007 Inward rectifier potassium channel 0.0109 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0097 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0088 PF00005 ABC transporter 0.0068 PF02254 TrkA-N domain 0.0068 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0058 PF05649 Peptidase family M13 0.0058 PF01431 Peptidase family M13 0.0058 PF07884 Vitamin K epoxide reductase family 0.0055 PF01401 Angiotensin-converting enzyme 0.0050 PF00017 SH2 domain 0.0050 PF00664 ABC transporter transmembrane region 0.0037 PF02159 Oestrogen receptor 0.0035 PF00069 Protein kinase domain 0.0031 PF12497 Estrogen receptor beta 0.0031 PF00822 PMP-22/EMP/MP20/Claudin family 0.0027 PF00018 SH3 domain 0.0024 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0024 PF08983 Domain of unknown function (DUF1856), 0.0020 PF00042 Globin 0.0007 PF00067 Cytochrome P450 0.0002 PF00089 Trypsin SUB365 C(~F)(:C) 0.2118 PF00204 DNA gyrase B 0.2118 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.2118 PF08070 DTHCT (NUC029), region 0.0879 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0544 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0544 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0370 PF01735 Lysophospholipase catalytic domain 0.0328 PF00576 HIUase/Transthyretin family 0.0288 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0287 PF00989 PAS fold 0.0279 PF00102 Protein-tyrosine phosphatase 0.0257 PF00191 Annexin 0.0241 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0232 PF02155 Glucocorticoid receptor 0.0229 PF00027 Cyclic nucleotide-binding domain 0.0224 PF00690 Cation transporter/ATPase, N-terminus 0.0224 PF00689 Cation transporting ATPase, C-terminus 0.0219 PF00194 Eukaryotic-type carbonic anhydrase 0.0216 PF03073 TspO/MBR family 0.0196 PF00122 E1-E2 ATPase 0.0191 PF02166 Androgen receptor 0.0187 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0187 PF00520 Ion transport protein 0.0181 PF00079 Serpin (serine protease inhibitor), 0.0171 PF00303 Thymidylate synthase 0.0168 PF00702 haloacid dehalogenase-like hydrolase 0.0166 PF00317 Ribonucleotide reductase, all-alpha domain 0.0166 PF03477 ATP cone domain 0.0166 PF02867 Ribonucleotide reductase, barrel domain 0.0162 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0149 PF01180 Dihydroorotate dehydrogenase 0.0143 PF00146 NADH dehydrogenase 0.0141 PF00168 C2 domain 0.0130 PF02214 K+ channel tetramerisation domain 0.0123 PF03098 Animal haem peroxidase 0.0121 PF01030 Receptor L domain 0.0121 PF00757 Furin-like cysteine rich region 0.0108 PF00493 MCM2/3/5 family 0.0108 PF03104 DNA polymerase family B, exonuclease domain 0.0108 PF08996 DNA Polymerase alpha zinc finger 0.0108 PF00136 DNA polymerase family B 0.0098 PF00248 Aldo/keto reductase family 0.0093 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0083 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0079 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0075 PF00273 Serum albumin family 0.0073 PF00028 Cadherin domain 0.0072 PF05406 WGR domain 0.0072 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0072 PF00533 BRCA1 C Terminus (BRCT), domain 0.0072 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0072 PF08063 PADR1 (NUC008), domain 0.0069 PF03062 MBOAT family 0.0068 PF03953 Tubulin C-terminal domain 0.0068 PF02460 Patched family 0.0068 PF00091 Tubulin/FtsZ family, GTPase domain 0.0067 PF00069 Protein kinase domain 0.0064 PF00654 Voltage gated chloride channel 0.0062 PF06448 Domain of Unknown Function (DUF1081), 0.0062 PF12491 Apolipoprotein B100 C terminal 0.0055 PF00229 TNF(Tumour Necrosis Factor), family 0.0052 PF01731 Arylesterase 0.0050 PF09396 Thrombin light chain 0.0049 PF00489 Interleukin-6/G-CSF/MGF family 0.0049 PF02196 Raf-like Ras-binding domain 0.0043 PF02180 Bcl-2 homology region 4 0.0043 PF01061 ABC-2 type transporter 0.0043 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0038 PF00405 Transferrin 0.0038 PF01347 Lipoprotein amino terminal region 0.0038 PF00005 ABC transporter 0.0037 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0028 PF07884 Vitamin K epoxide reductase family 0.0027 PF00664 ABC transporter transmembrane region 0.0026 PF00754 F5/8 type C domain 0.0024 PF00017 SH2 domain 0.0024 PF00058 Low-density lipoprotein receptor repeat class B 0.0024 PF00554 Rel homology domain (RHD), 0.0023 PF08919 F-actin binding 0.0022 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0021 PF00018 SH3 domain 0.0021 PF01391 Collagen triple helix repeat (20 copies), 0.0020 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0019 PF00656 Caspase domain 0.0018 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0017 PF01187 Macrophage migration inhibitory factor (MIF), 0.0017 PF00305 Lipoxygenase 0.0017 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0017 PF00071 Ras family 0.0016 PF03957 Jun-like transcription factor 0.0016 PF03171 2OG-Fe(II), oxygenase superfamily 0.0016 PF01596 O-methyltransferase 0.0016 PF00042 Globin 0.0015 PF00291 Pyridoxal-phosphate dependent enzyme 0.0015 PF00406 Adenylate kinase 0.0015 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0014 PF00341 Platelet-derived growth factor (PDGF), 0.0014 PF00432 Prenyltransferase and squalene oxidase repeat 0.0014 PF00266 Aminotransferase class-V 0.0014 PF01477 PLAT/LH2 domain 0.0013 PF03949 Malic enzyme, NAD binding domain 0.0013 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0013 PF02864 STAT protein, DNA binding domain 0.0013 PF02865 STAT protein, protein interaction domain 0.0013 PF08771 Rapamycin binding domain 0.0013 PF02260 FATC domain 0.0013 PF02798 Glutathione S-transferase, N-terminal domain 0.0013 PF00390 Malic enzyme, N-terminal domain 0.0013 PF01017 STAT protein, all-alpha domain 0.0013 PF02259 FAT domain 0.0013 PF08403 Amino acid permease N-terminal 0.0013 PF00043 Glutathione S-transferase, C-terminal domain 0.0012 PF02394 Interleukin-1 propeptide 0.0012 PF00340 Interleukin-1 / 18 0.0011 PF01023 S-100/ICaBP type calcium binding domain 0.0010 PF00271 Helicase conserved C-terminal domain 0.0010 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0010 PF02803 Thiolase, C-terminal domain 0.0010 PF00975 Thioesterase domain 0.0010 PF08659 KR domain 0.0010 PF00108 Thiolase, N-terminal domain 0.0010 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0010 PF00155 Aminotransferase class I and II 0.0010 PF00040 Fibronectin type II domain 0.0010 PF00698 Acyl transferase domain 0.0010 PF00377 Prion/Doppel alpha-helical domain 0.0009 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0009 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0009 PF00821 Phosphoenolpyruvate carboxykinase 0.0009 PF02793 Hormone receptor domain 0.0009 PF00002 7 transmembrane receptor (Secretin family), 0.0009 PF01202 Shikimate kinase 0.0009 PF02059 Interleukin-3 0.0009 PF00085 Thioredoxin 0.0009 PF00176 SNF2 family N-terminal domain 0.0009 PF00170 bZIP transcription factor 0.0008 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0008 PF00755 Choline/Carnitine o-acyltransferase 0.0007 PF01068 ATP dependent DNA ligase domain 0.0007 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0007 PF00094 von Willebrand factor type D domain 0.0007 PF02824 TGS domain 0.0007 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0007 PF03034 Phosphatidyl serine synthase 0.0007 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0007 PF02025 Interleukin 5 0.0007 PF00628 PHD-finger 0.0007 PF00781 Diacylglycerol kinase catalytic domain 0.0007 PF01388 ARID/BRIGHT DNA binding domain 0.0007 PF08429 PLU-1-like protein 0.0007 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0007 PF02525 Flavodoxin-like fold 0.0007 PF00342 Phosphoglucose isomerase 0.0007 PF01753 MYND finger 0.0007 PF02373 JmjC domain 0.0007 PF04679 ATP dependent DNA ligase C terminal region 0.0007 PF02375 jmjN domain 0.0007 PF00609 Diacylglycerol kinase accessory domain 0.0007 PF00860 Permease family 0.0007 PF00274 Fructose-bisphosphate aldolase class-I 0.0007 PF00183 Hsp90 protein 0.0007 PF02928 C5HC2 zinc finger 0.0007 PF08742 C8 domain 0.0006 PF00057 Low-density lipoprotein receptor domain class A 0.0006 PF01425 Amidase 0.0006 PF01429 Methyl-CpG binding domain 0.0006 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0006 PF00343 Carbohydrate phosphorylase 0.0006 PF00464 Serine hydroxymethyltransferase 0.0005 PF01833 IPT/TIG domain 0.0005 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0005 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0005 PF00270 DEAD/DEAH box helicase 0.0005 PF01130 CD36 family 0.0005 PF11404 Potassium voltage-gated channel 0.0005 PF01437 Plexin repeat 0.0005 PF00246 Zinc carboxypeptidase 0.0005 PF07647 SAM domain (Sterile alpha motif), 0.0005 PF01433 Peptidase family M1 0.0005 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0005 PF00969 Class II histocompatibility antigen, beta domain 0.0005 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0005 PF01403 Sema domain 0.0005 PF00717 Peptidase S24-like 0.0005 PF02666 Phosphatidylserine decarboxylase 0.0005 PF00550 Phosphopantetheine attachment site 0.0005 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0005 PF03351 DOMON domain 0.0005 PF09193 Cholecystokinin A receptor, N-terminal 0.0005 PF03476 MOSC N-terminal beta barrel domain 0.0005 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0005 PF03473 MOSC domain 0.0005 PF02403 Seryl-tRNA synthetase N-terminal domain 0.0005 PF00186 Dihydrofolate reductase 0.0004 PF03360 Glycosyltransferase family 43 0.0004 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.0004 PF02898 Nitric oxide synthase, oxygenase domain 0.0004 PF03623 Focal adhesion targeting region 0.0004 PF00294 pfkB family carbohydrate kinase 0.0004 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0004 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0004 PF00051 Kringle domain 0.0004 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0003 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0003 PF00714 Interferon gamma 0.0003 PF00020 TNFR/NGFR cysteine-rich region 0.0003 PF00019 Transforming growth factor beta like domain 0.0003 PF01212 Beta-eliminating lyase 0.0003 PF00688 TGF-beta propeptide 0.0003 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0003 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0003 PF07690 Major Facilitator Superfamily 0.0003 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 0.0003 PF02347 Glycine cleavage system P-protein 0.0003 PF00151 Lipase 0.0003 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0003 PF01168 Alanine racemase, N-terminal domain 0.0003 PF00373 FERM central domain 0.0002 PF00619 Caspase recruitment domain 0.0002 PF01462 Leucine rich repeat N-terminal domain 0.0002 PF00682 HMGL-like 0.0002 PF00571 CBS domain 0.0002 PF00202 Aminotransferase class-III 0.0002 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0002 PF00787 PX domain 0.0001 PF00792 Phosphoinositide 3-kinase C2 0.0001 PF00794 PI3-kinase family, ras-binding domain 0.0001 PF00648 Calpain family cysteine protease 0.0001 PF06459 Ryanodine Receptor TM 4-6 0.0001 PF08454 RyR and IP3R Homology associated 0.0001 PF00354 Pentaxin family 0.0001 PF02815 MIR domain 0.0001 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0001 PF03024 Folate receptor family 0.0001 PF00622 SPRY domain 0.0001 PF01365 RIH domain 0.0001 PF04961 Formiminotransferase-cyclodeaminase 0.0001 PF02210 Laminin G domain 0.0001 PF02971 Formiminotransferase domain 0.0001 PF00227 Proteasome subunit 0.0001 PF01067 Calpain large subunit, domain III 0.0001 PF07648 Kazal-type serine protease inhibitor domain 0.0001 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0001 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0001 PF00024 PAN domain 0.0001 PF00025 ADP-ribosylation factor family 0.0001 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0001 PF02026 RyR domain 0.0001 PF04756 OST3 / OST6 family 0.0001 PF03129 Anticodon binding domain 0.0001 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0001 PF00433 Protein kinase C terminal domain 0.0001 PF02758 PAAD/DAPIN/Pyrin domain 0.0001 PF00074 Pancreatic ribonuclease 0.0001 PF07686 Immunoglobulin V-set domain 0.0001 PF08709 Inositol 1,4,5-trisphosphate/ryanodine receptor 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0001 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0001 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0001 PF00032 Cytochrome b(C-terminal), /b6/petD SUB596 C:C-C-C-C 0.2071 PF00001 7 transmembrane receptor (rhodopsin family), 0.0949 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0693 PF00209 Sodium:neurotransmitter symporter family 0.0629 PF03098 Animal haem peroxidase 0.0574 PF00194 Eukaryotic-type carbonic anhydrase 0.0502 PF08070 DTHCT (NUC029), region 0.0502 PF00204 DNA gyrase B 0.0502 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0466 PF06512 Sodium ion transport-associated 0.0417 PF00520 Ion transport protein 0.0394 PF03073 TspO/MBR family 0.0244 PF00989 PAS fold 0.0204 PF00027 Cyclic nucleotide-binding domain 0.0202 PF09396 Thrombin light chain 0.0179 PF00102 Protein-tyrosine phosphatase 0.0175 PF00186 Dihydrofolate reductase 0.0157 PF01593 Flavin containing amine oxidoreductase 0.0151 PF00576 HIUase/Transthyretin family 0.0138 PF08403 Amino acid permease N-terminal 0.0125 PF01007 Inward rectifier potassium channel 0.0106 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0095 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0086 PF00005 ABC transporter 0.0066 PF02254 TrkA-N domain 0.0066 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0057 PF05649 Peptidase family M13 0.0057 PF01431 Peptidase family M13 0.0057 PF07884 Vitamin K epoxide reductase family 0.0054 PF01401 Angiotensin-converting enzyme 0.0049 PF00664 ABC transporter transmembrane region 0.0049 PF00017 SH2 domain 0.0036 PF02159 Oestrogen receptor 0.0034 PF00069 Protein kinase domain 0.0030 PF00822 PMP-22/EMP/MP20/Claudin family 0.0030 PF12497 Estrogen receptor beta 0.0026 PF00018 SH3 domain 0.0024 PF08983 Domain of unknown function (DUF1856), 0.0024 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0019 PF00042 Globin 0.0007 PF00067 Cytochrome P450 0.0002 PF00089 Trypsin SUB609 C-C-C-C:C 0.2071 PF00001 7 transmembrane receptor (rhodopsin family), 0.0949 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0693 PF00209 Sodium:neurotransmitter symporter family 0.0629 PF03098 Animal haem peroxidase 0.0574 PF00194 Eukaryotic-type carbonic anhydrase 0.0502 PF08070 DTHCT (NUC029), region 0.0502 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0502 PF00204 DNA gyrase B 0.0466 PF06512 Sodium ion transport-associated 0.0417 PF00520 Ion transport protein 0.0394 PF03073 TspO/MBR family 0.0244 PF00989 PAS fold 0.0204 PF00027 Cyclic nucleotide-binding domain 0.0202 PF09396 Thrombin light chain 0.0179 PF00102 Protein-tyrosine phosphatase 0.0175 PF00186 Dihydrofolate reductase 0.0157 PF01593 Flavin containing amine oxidoreductase 0.0151 PF00576 HIUase/Transthyretin family 0.0138 PF08403 Amino acid permease N-terminal 0.0125 PF01007 Inward rectifier potassium channel 0.0106 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0095 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0086 PF00005 ABC transporter 0.0066 PF02254 TrkA-N domain 0.0066 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0057 PF07884 Vitamin K epoxide reductase family 0.0057 PF05649 Peptidase family M13 0.0057 PF01431 Peptidase family M13 0.0054 PF01401 Angiotensin-converting enzyme 0.0049 PF00017 SH2 domain 0.0049 PF00664 ABC transporter transmembrane region 0.0036 PF02159 Oestrogen receptor 0.0034 PF00069 Protein kinase domain 0.0030 PF12497 Estrogen receptor beta 0.0030 PF00822 PMP-22/EMP/MP20/Claudin family 0.0026 PF00018 SH3 domain 0.0024 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0024 PF08983 Domain of unknown function (DUF1856), 0.0019 PF00042 Globin 0.0007 PF00067 Cytochrome P450 0.0002 PF00089 Trypsin SUB243 >= 1 saturated or aromatic carbon-only ring size 9 0.2061 PF02159 Oestrogen receptor 0.1748 PF02155 Glucocorticoid receptor 0.1745 PF00191 Annexin 0.1521 PF00105 Zinc finger, C4 type (two domains), 0.1517 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1493 PF02161 Progesterone receptor 0.1141 PF02166 Androgen receptor 0.0818 PF01735 Lysophospholipase catalytic domain 0.0678 PF00079 Serpin (serine protease inhibitor), 0.0326 PF00168 C2 domain 0.0260 PF12497 Estrogen receptor beta 0.0212 PF08035 Opioids neuropeptide 0.0212 PF00976 Corticotropin ACTH domain 0.0212 PF08384 Pro-opiomelanocortin, N-terminal region 0.0169 PF00689 Cation transporting ATPase, C-terminus 0.0169 PF00690 Cation transporter/ATPase, N-terminus 0.0151 PF00122 E1-E2 ATPase 0.0127 PF00702 haloacid dehalogenase-like hydrolase 0.0114 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0114 PF07648 Kazal-type serine protease inhibitor domain 0.0113 PF00554 Rel homology domain (RHD), 0.0111 PF00031 Cystatin domain 0.0111 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0105 PF00212 Atrial natriuretic peptide 0.0095 PF08377 MAP2/Tau projection domain 0.0095 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0082 PF00067 Cytochrome P450 0.0079 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0076 PF01607 Chitin binding Peritrophin-A domain 0.0076 PF00704 Glycosyl hydrolases family 18 0.0073 PF00039 Fibronectin type I domain 0.0065 PF02898 Nitric oxide synthase, oxygenase domain 0.0059 PF00106 short chain dehydrogenase 0.0058 PF00531 Death domain 0.0056 PF00762 Ferrochelatase 0.0049 PF09164 Vitamin D binding protein, domain III 0.0049 PF00654 Voltage gated chloride channel 0.0047 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0047 PF02180 Bcl-2 homology region 4 0.0039 PF00305 Lipoxygenase 0.0039 PF00258 Flavodoxin 0.0039 PF00667 FAD binding domain 0.0034 PF00884 Sulfatase 0.0034 PF02038 ATP1G1/PLM/MAT8 family 0.0032 PF00175 Oxidoreductase NAD-binding domain 0.0031 PF00432 Prenyltransferase and squalene oxidase repeat 0.0030 PF07884 Vitamin K epoxide reductase family 0.0021 PF00023 Ankyrin repeat 0.0015 PF00341 Platelet-derived growth factor (PDGF), 0.0014 PF01477 PLAT/LH2 domain 0.0014 PF00969 Class II histocompatibility antigen, beta domain 0.0014 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0013 PF02210 Laminin G domain 0.0013 PF04756 OST3 / OST6 family 0.0013 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0013 PF00377 Prion/Doppel alpha-helical domain 0.0013 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0011 PF01593 Flavin containing amine oxidoreductase 0.0008 PF00020 TNFR/NGFR cysteine-rich region 0.0008 PF00688 TGF-beta propeptide 0.0008 PF00019 Transforming growth factor beta like domain 0.0007 PF05193 Peptidase M16 inactive domain 0.0007 PF00675 Insulinase (Peptidase family M16), 0.0007 PF01429 Methyl-CpG binding domain 0.0006 PF00714 Interferon gamma 0.0005 PF02394 Interleukin-1 propeptide 0.0005 PF00340 Interleukin-1 / 18 0.0004 PF05649 Peptidase family M13 0.0004 PF01431 Peptidase family M13 0.0003 PF00656 Caspase domain 0.0002 PF01391 Collagen triple helix repeat (20 copies), SUB352 C(~C)(~N) 0.2058 PF00001 7 transmembrane receptor (rhodopsin family), 0.0538 PF03073 TspO/MBR family 0.0365 PF00209 Sodium:neurotransmitter symporter family 0.0361 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0351 PF01401 Angiotensin-converting enzyme 0.0331 PF06512 Sodium ion transport-associated 0.0324 PF00005 ABC transporter 0.0279 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0277 PF00664 ABC transporter transmembrane region 0.0217 PF00989 PAS fold 0.0193 PF00520 Ion transport protein 0.0192 PF01593 Flavin containing amine oxidoreductase 0.0190 PF00069 Protein kinase domain 0.0182 PF00186 Dihydrofolate reductase 0.0178 PF00027 Cyclic nucleotide-binding domain 0.0171 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0171 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0145 PF01048 Phosphorylase superfamily 0.0107 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0082 PF00204 DNA gyrase B 0.0082 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0082 PF08070 DTHCT (NUC029), region 0.0079 PF03953 Tubulin C-terminal domain 0.0079 PF00091 Tubulin/FtsZ family, GTPase domain 0.0063 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0063 PF02180 Bcl-2 homology region 4 0.0056 PF08983 Domain of unknown function (DUF1856), 0.0055 PF01061 ABC-2 type transporter 0.0054 PF00017 SH2 domain 0.0023 PF08491 Squalene epoxidase 0.0023 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0022 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0021 PF08919 F-actin binding 0.0021 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0015 PF02223 Thymidylate kinase 0.0015 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0015 PF00018 SH3 domain 0.0015 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0010 PF01467 Cytidylyltransferase 0.0005 PF01431 Peptidase family M13 0.0005 PF05649 Peptidase family M13 0.0004 PF00962 Adenosine/AMP deaminase 0.0003 PF01007 Inward rectifier potassium channel 0.0003 PF02267 ADP-ribosyl cyclase 0.0002 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0002 PF00464 Serine hydroxymethyltransferase 0.0002 PF01842 ACT domain 0.0002 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0002 PF01126 Heme oxygenase 0.0002 PF09396 Thrombin light chain 0.0001 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0001 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0001 PF00303 Thymidylate synthase 0.0001 PF00551 Formyl transferase 0.0001 PF00255 Glutathione peroxidase 0.0001 PF01234 NNMT/PNMT/TEMT family 0.0001 PF01590 GAF domain 0.0001 PF00042 Globin 0.0001 PF00043 Glutathione S-transferase, C-terminal domain 0.0001 PF03807 NADP oxidoreductase coenzyme F420-dependent 0.0001 PF02798 Glutathione S-transferase, N-terminal domain SUB488 N-C=N-C 0.2053 PF00186 Dihydrofolate reductase 0.1355 PF01048 Phosphorylase superfamily 0.1091 PF00478 IMP dehydrogenase / GMP reductase domain 0.0968 PF00069 Protein kinase domain 0.0843 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0620 PF03073 TspO/MBR family 0.0619 PF00571 CBS domain 0.0591 PF00962 Adenosine/AMP deaminase 0.0426 PF00156 Phosphoribosyl transferase domain 0.0385 PF01590 GAF domain 0.0355 PF00106 short chain dehydrogenase 0.0348 PF08240 Alcohol dehydrogenase GroES-like domain 0.0342 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0271 PF00107 Zinc-binding dehydrogenase 0.0269 PF00018 SH3 domain 0.0254 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0254 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0242 PF00017 SH2 domain 0.0240 PF08919 F-actin binding 0.0227 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0225 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0225 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0225 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0171 PF00858 Amiloride-sensitive sodium channel 0.0159 PF00171 Aldehyde dehydrogenase family 0.0153 PF09396 Thrombin light chain 0.0150 PF01030 Receptor L domain 0.0150 PF00757 Furin-like cysteine rich region 0.0141 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0137 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0137 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0127 PF01268 Formate--tetrahydrofolate ligase 0.0116 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0116 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0094 PF01122 Eukaryotic cobalamin-binding protein 0.0091 PF01687 Riboflavin kinase 0.0080 PF00821 Phosphoenolpyruvate carboxykinase 0.0068 PF00501 AMP-binding enzyme 0.0064 PF02310 B12 binding domain 0.0060 PF01923 Cobalamin adenosyltransferase 0.0060 PF01642 Methylmalonyl-CoA mutase 0.0060 PF03308 ArgK protein 0.0053 PF01808 AICARFT/IMPCHase bienzyme 0.0030 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0030 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0029 PF02607 B12 binding domain 0.0029 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0029 PF00809 Pterin binding enzyme 0.0028 PF00431 CUB domain 0.0026 PF00667 FAD binding domain 0.0026 PF00258 Flavodoxin 0.0026 PF00175 Oxidoreductase NAD-binding domain 0.0025 PF00317 Ribonucleotide reductase, all-alpha domain 0.0025 PF03477 ATP cone domain 0.0025 PF02867 Ribonucleotide reductase, barrel domain 0.0025 PF02267 ADP-ribosyl cyclase 0.0023 PF02223 Thymidylate kinase 0.0019 PF01467 Cytidylyltransferase 0.0018 PF07645 Calcium-binding EGF domain 0.0015 PF01575 MaoC like domain 0.0015 PF02574 Homocysteine S-methyltransferase 0.0015 PF00970 Oxidoreductase FAD-binding domain 0.0015 PF02036 SCP-2 sterol transfer family 0.0015 PF01652 Eukaryotic initiation factor 4E 0.0014 PF12473 Kinesin protein 0.0014 PF12423 Kinesin protein 1B 0.0014 PF01119 DNA mismatch repair protein, C-terminal domain 0.0014 PF00498 FHA domain 0.0014 PF08676 MutL C terminal dimerisation domain 0.0013 PF08996 DNA Polymerase alpha zinc finger 0.0013 PF03104 DNA polymerase family B, exonuclease domain 0.0013 PF01404 Ephrin receptor ligand binding domain 0.0013 PF00536 SAM domain (Sterile alpha motif), 0.0013 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0013 PF00136 DNA polymerase family B 0.0013 PF10397 Adenylosuccinate lyase C-terminus 0.0005 PF00248 Aldo/keto reductase family 0.0005 PF01230 HIT domain 0.0005 PF01126 Heme oxygenase 0.0003 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0003 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0003 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0003 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF02233 NAD(P), transhydrogenase beta subunit 0.0002 PF00390 Malic enzyme, N-terminal domain 0.0002 PF03949 Malic enzyme, NAD binding domain 0.0002 PF01370 NAD dependent epimerase/dehydratase family 0.0002 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0002 PF00676 Dehydrogenase E1 component 0.0002 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0002 PF03770 Inositol polyphosphate kinase 0.0002 PF00057 Low-density lipoprotein receptor domain class A 0.0002 PF00058 Low-density lipoprotein receptor repeat class B 0.0002 PF00348 Polyprenyl synthetase 0.0002 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0002 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0002 PF02525 Flavodoxin-like fold 0.0001 PF06212 GRIM-19 protein 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF10531 SLBB domain 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF01437 Plexin repeat 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF02779 Transketolase, pyrimidine binding domain 0.0001 PF02817 e3 binding domain 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF00794 PI3-kinase family, ras-binding domain 0.0001 PF00792 Phosphoinositide 3-kinase C2 0.0001 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF00400 WD domain, G-beta repeat 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF00225 Kinesin motor domain 0.0001 PF01712 Deoxynucleoside kinase 0.0001 PF08040 MNLL subunit 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0001 PF00931 NB-ARC domain 0.0001 PF00378 Enoyl-CoA hydratase/isomerase family 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF10276 Zinc-finger domain 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF01403 Sema domain 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0001 PF01833 IPT/TIG domain 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF05347 Complex 1 protein (LYR family), 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region SUB344 C(~C)(~Cl)(~H) 0.2051 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.2043 PF00146 NADH dehydrogenase 0.1334 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1334 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1327 PF00690 Cation transporter/ATPase, N-terminus 0.1327 PF00689 Cation transporting ATPase, C-terminus 0.1258 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1258 PF02254 TrkA-N domain 0.1176 PF00122 E1-E2 ATPase 0.1054 PF00702 haloacid dehalogenase-like hydrolase 0.0906 PF02888 Calmodulin binding domain 0.0906 PF03530 Calcium-activated SK potassium channel 0.0905 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0905 PF00631 GGL domain 0.0762 PF00194 Eukaryotic-type carbonic anhydrase 0.0754 PF02214 K+ channel tetramerisation domain 0.0731 PF00191 Annexin 0.0613 PF01007 Inward rectifier potassium channel 0.0608 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0436 PF00520 Ion transport protein 0.0435 PF12497 Estrogen receptor beta 0.0430 PF00273 Serum albumin family 0.0399 PF07885 Ion channel 0.0372 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0354 PF00060 Ligand-gated ion channel 0.0328 PF08403 Amino acid permease N-terminal 0.0305 PF02155 Glucocorticoid receptor 0.0275 PF02159 Oestrogen receptor 0.0250 PF01094 Receptor family ligand binding region 0.0180 PF08377 MAP2/Tau projection domain 0.0180 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0170 PF00079 Serpin (serine protease inhibitor), 0.0165 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0164 PF02008 CXXC zinc finger domain 0.0164 PF06464 DMAP1-binding Domain 0.0164 PF01426 BAH domain 0.0129 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0107 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0096 PF00324 Amino acid permease 0.0090 PF00287 Sodium / potassium ATPase beta chain 0.0086 PF00145 C-5 cytosine-specific DNA methylase 0.0083 PF00091 Tubulin/FtsZ family, GTPase domain 0.0083 PF03953 Tubulin C-terminal domain 0.0069 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0067 PF00462 Glutaredoxin 0.0061 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0059 PF00102 Protein-tyrosine phosphatase 0.0046 PF00576 HIUase/Transthyretin family 0.0035 PF03073 TspO/MBR family 0.0035 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0028 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0027 PF01735 Lysophospholipase catalytic domain 0.0026 PF00230 Major intrinsic protein 0.0024 PF00667 FAD binding domain 0.0024 PF00105 Zinc finger, C4 type (two domains), 0.0024 PF00258 Flavodoxin 0.0023 PF02898 Nitric oxide synthase, oxygenase domain 0.0023 PF00175 Oxidoreductase NAD-binding domain 0.0022 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0022 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0022 PF00204 DNA gyrase B 0.0022 PF08070 DTHCT (NUC029), region 0.0022 PF00017 SH2 domain 0.0021 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0021 PF00018 SH3 domain 0.0019 PF02166 Androgen receptor 0.0017 PF04679 ATP dependent DNA ligase C terminal region 0.0017 PF01068 ATP dependent DNA ligase domain 0.0016 PF01770 Reduced folate carrier 0.0016 PF00478 IMP dehydrogenase / GMP reductase domain 0.0015 PF08919 F-actin binding 0.0015 PF01122 Eukaryotic cobalamin-binding protein 0.0014 PF00962 Adenosine/AMP deaminase 0.0012 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0011 PF00854 POT family 0.0011 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0011 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0011 PF00536 SAM domain (Sterile alpha motif), 0.0011 PF10397 Adenylosuccinate lyase C-terminus 0.0011 PF01404 Ephrin receptor ligand binding domain 0.0010 PF02310 B12 binding domain 0.0010 PF01923 Cobalamin adenosyltransferase 0.0010 PF03308 ArgK protein 0.0010 PF00156 Phosphoribosyl transferase domain 0.0010 PF01642 Methylmalonyl-CoA mutase 0.0009 PF01687 Riboflavin kinase 0.0009 PF00958 GMP synthase C terminal domain 0.0008 PF02865 STAT protein, protein interaction domain 0.0008 PF02864 STAT protein, DNA binding domain 0.0008 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0008 PF00303 Thymidylate synthase 0.0008 PF00794 PI3-kinase family, ras-binding domain 0.0008 PF01017 STAT protein, all-alpha domain 0.0008 PF00792 Phosphoinositide 3-kinase C2 0.0007 PF00206 Lyase 0.0005 PF01437 Plexin repeat 0.0005 PF00489 Interleukin-6/G-CSF/MGF family 0.0005 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0005 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0005 PF01833 IPT/TIG domain 0.0005 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0005 PF02441 Flavoprotein 0.0005 PF00571 CBS domain 0.0005 PF01403 Sema domain 0.0005 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0004 PF00405 Transferrin 0.0004 PF00654 Voltage gated chloride channel 0.0004 PF00970 Oxidoreductase FAD-binding domain 0.0004 PF00625 Guanylate kinase 0.0004 PF00069 Protein kinase domain 0.0004 PF00245 Alkaline phosphatase 0.0004 PF00709 Adenylosuccinate synthetase 0.0004 PF00459 Inositol monophosphatase family 0.0003 PF07678 A-macroglobulin complement component 0.0003 PF07677 A-macroglobulin receptor 0.0003 PF00117 Glutamine amidotransferase class-I 0.0003 PF02607 B12 binding domain 0.0003 PF08063 PADR1 (NUC008), domain 0.0003 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0003 PF00431 CUB domain 0.0003 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0003 PF05406 WGR domain 0.0003 PF00533 BRCA1 C Terminus (BRCT), domain 0.0003 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0003 PF01835 MG2 domain 0.0003 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0003 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0003 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0003 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0003 PF00809 Pterin binding enzyme 0.0003 PF02196 Raf-like Ras-binding domain 0.0003 PF00779 BTK motif 0.0003 PF01180 Dihydroorotate dehydrogenase 0.0002 PF12126 Protein of unknown function (DUF3583), 0.0002 PF00310 Glutamine amidotransferases class-II 0.0002 PF00994 Probable molybdopterin binding domain 0.0002 PF02984 Cyclin, C-terminal domain 0.0002 PF00989 PAS fold 0.0002 PF03453 MoeA N-terminal region (domain I and II), 0.0002 PF03454 MoeA C-terminal region (domain IV), 0.0002 PF01369 Sec7 domain 0.0002 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0002 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0002 PF00089 Trypsin 0.0002 PF02828 L27 domain 0.0002 PF00134 Cyclin, N-terminal domain 0.0002 PF02743 Cache domain 0.0002 PF07970 Endoplasmic reticulum vesicle transporter 0.0002 PF00514 Armadillo/beta-catenin-like repeat 0.0002 PF08399 VWA N-terminal 0.0001 PF01733 Nucleoside transporter 0.0001 PF00581 Rhodanese-like domain 0.0001 PF06617 M-phase inducer phosphatase 0.0001 PF07653 Variant SH3 domain 0.0001 PF00027 Cyclic nucleotide-binding domain 0.0001 PF02189 Immunoreceptor tyrosine-based activation motif 0.0001 PF00042 Globin 0.0001 PF00041 Fibronectin type III domain 0.0001 PF05193 Peptidase M16 inactive domain 0.0001 PF08763 Voltage gated calcium channel IQ domain 0.0001 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0001 PF03957 Jun-like transcription factor 0.0001 PF00406 Adenylate kinase 0.0001 PF00675 Insulinase (Peptidase family M16), SUB635 C-C-C:C-C 0.2044 PF00001 7 transmembrane receptor (rhodopsin family), 0.0937 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0684 PF00209 Sodium:neurotransmitter symporter family 0.0621 PF03098 Animal haem peroxidase 0.0567 PF00194 Eukaryotic-type carbonic anhydrase 0.0496 PF08070 DTHCT (NUC029), region 0.0496 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0496 PF00204 DNA gyrase B 0.0460 PF06512 Sodium ion transport-associated 0.0412 PF00520 Ion transport protein 0.0388 PF03073 TspO/MBR family 0.0241 PF00989 PAS fold 0.0201 PF00027 Cyclic nucleotide-binding domain 0.0199 PF09396 Thrombin light chain 0.0177 PF00102 Protein-tyrosine phosphatase 0.0173 PF00186 Dihydrofolate reductase 0.0155 PF01593 Flavin containing amine oxidoreductase 0.0149 PF00576 HIUase/Transthyretin family 0.0137 PF08403 Amino acid permease N-terminal 0.0124 PF01007 Inward rectifier potassium channel 0.0105 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0094 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0085 PF00005 ABC transporter 0.0065 PF02254 TrkA-N domain 0.0065 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0056 PF05649 Peptidase family M13 0.0056 PF07884 Vitamin K epoxide reductase family 0.0056 PF01431 Peptidase family M13 0.0053 PF01401 Angiotensin-converting enzyme 0.0049 PF00017 SH2 domain 0.0048 PF00664 ABC transporter transmembrane region 0.0035 PF02159 Oestrogen receptor 0.0034 PF00069 Protein kinase domain 0.0030 PF00822 PMP-22/EMP/MP20/Claudin family 0.0030 PF12497 Estrogen receptor beta 0.0026 PF00018 SH3 domain 0.0023 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0023 PF08983 Domain of unknown function (DUF1856), 0.0019 PF00042 Globin 0.0007 PF00067 Cytochrome P450 0.0002 PF00089 Trypsin SUB669 C-C:C-C-C 0.2044 PF00001 7 transmembrane receptor (rhodopsin family), 0.0937 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0684 PF00209 Sodium:neurotransmitter symporter family 0.0621 PF03098 Animal haem peroxidase 0.0567 PF00194 Eukaryotic-type carbonic anhydrase 0.0496 PF00204 DNA gyrase B 0.0496 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0496 PF08070 DTHCT (NUC029), region 0.0460 PF06512 Sodium ion transport-associated 0.0412 PF00520 Ion transport protein 0.0388 PF03073 TspO/MBR family 0.0241 PF00989 PAS fold 0.0201 PF00027 Cyclic nucleotide-binding domain 0.0199 PF09396 Thrombin light chain 0.0177 PF00102 Protein-tyrosine phosphatase 0.0173 PF00186 Dihydrofolate reductase 0.0155 PF01593 Flavin containing amine oxidoreductase 0.0149 PF00576 HIUase/Transthyretin family 0.0137 PF08403 Amino acid permease N-terminal 0.0124 PF01007 Inward rectifier potassium channel 0.0105 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0094 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0085 PF00005 ABC transporter 0.0065 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0065 PF02254 TrkA-N domain 0.0056 PF05649 Peptidase family M13 0.0056 PF07884 Vitamin K epoxide reductase family 0.0056 PF01431 Peptidase family M13 0.0053 PF01401 Angiotensin-converting enzyme 0.0049 PF00017 SH2 domain 0.0048 PF00664 ABC transporter transmembrane region 0.0035 PF02159 Oestrogen receptor 0.0034 PF00069 Protein kinase domain 0.0030 PF00822 PMP-22/EMP/MP20/Claudin family 0.0030 PF12497 Estrogen receptor beta 0.0026 PF00018 SH3 domain 0.0023 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0023 PF08983 Domain of unknown function (DUF1856), 0.0019 PF00042 Globin 0.0007 PF00067 Cytochrome P450 0.0002 PF00089 Trypsin SUB362 C(~Cl)(~H) 0.2041 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.2033 PF00146 NADH dehydrogenase 0.1330 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1330 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1278 PF00690 Cation transporter/ATPase, N-terminus 0.1278 PF00689 Cation transporting ATPase, C-terminus 0.1253 PF03493 Calcium-activated BK potassium channel alpha subunit 0.1253 PF02254 TrkA-N domain 0.1132 PF00122 E1-E2 ATPase 0.1014 PF00702 haloacid dehalogenase-like hydrolase 0.0903 PF02888 Calmodulin binding domain 0.0903 PF03530 Calcium-activated SK potassium channel 0.0902 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0902 PF00631 GGL domain 0.0754 PF00194 Eukaryotic-type carbonic anhydrase 0.0749 PF02214 K+ channel tetramerisation domain 0.0730 PF00191 Annexin 0.0612 PF01007 Inward rectifier potassium channel 0.0605 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0434 PF00520 Ion transport protein 0.0432 PF12497 Estrogen receptor beta 0.0428 PF00273 Serum albumin family 0.0398 PF07885 Ion channel 0.0353 PF00060 Ligand-gated ion channel 0.0328 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0327 PF08403 Amino acid permease N-terminal 0.0305 PF02155 Glucocorticoid receptor 0.0274 PF02159 Oestrogen receptor 0.0250 PF01094 Receptor family ligand binding region 0.0179 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0179 PF08377 MAP2/Tau projection domain 0.0169 PF00079 Serpin (serine protease inhibitor), 0.0165 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0164 PF01426 BAH domain 0.0164 PF06464 DMAP1-binding Domain 0.0164 PF02008 CXXC zinc finger domain 0.0129 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0107 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0095 PF00324 Amino acid permease 0.0086 PF00145 C-5 cytosine-specific DNA methylase 0.0079 PF00287 Sodium / potassium ATPase beta chain 0.0073 PF00091 Tubulin/FtsZ family, GTPase domain 0.0073 PF03953 Tubulin C-terminal domain 0.0069 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0067 PF00462 Glutaredoxin 0.0060 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0056 PF00102 Protein-tyrosine phosphatase 0.0046 PF00576 HIUase/Transthyretin family 0.0035 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0034 PF03073 TspO/MBR family 0.0028 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0027 PF01735 Lysophospholipase catalytic domain 0.0024 PF00105 Zinc finger, C4 type (two domains), 0.0023 PF00230 Major intrinsic protein 0.0022 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0022 PF08070 DTHCT (NUC029), region 0.0022 PF00204 DNA gyrase B 0.0021 PF00175 Oxidoreductase NAD-binding domain 0.0021 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0021 PF00258 Flavodoxin 0.0021 PF00667 FAD binding domain 0.0020 PF02898 Nitric oxide synthase, oxygenase domain 0.0020 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0020 PF00017 SH2 domain 0.0019 PF02166 Androgen receptor 0.0019 PF00018 SH3 domain 0.0015 PF01068 ATP dependent DNA ligase domain 0.0015 PF04679 ATP dependent DNA ligase C terminal region 0.0014 PF01770 Reduced folate carrier 0.0014 PF00478 IMP dehydrogenase / GMP reductase domain 0.0013 PF01122 Eukaryotic cobalamin-binding protein 0.0013 PF00962 Adenosine/AMP deaminase 0.0013 PF08919 F-actin binding 0.0011 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0010 PF00536 SAM domain (Sterile alpha motif), 0.0010 PF01404 Ephrin receptor ligand binding domain 0.0010 PF10397 Adenylosuccinate lyase C-terminus 0.0009 PF00854 POT family 0.0009 PF01642 Methylmalonyl-CoA mutase 0.0009 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0009 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0009 PF03308 ArgK protein 0.0009 PF00156 Phosphoribosyl transferase domain 0.0009 PF01923 Cobalamin adenosyltransferase 0.0008 PF00958 GMP synthase C terminal domain 0.0008 PF02310 B12 binding domain 0.0008 PF00303 Thymidylate synthase 0.0008 PF01687 Riboflavin kinase 0.0007 PF01017 STAT protein, all-alpha domain 0.0007 PF00794 PI3-kinase family, ras-binding domain 0.0007 PF00792 Phosphoinositide 3-kinase C2 0.0007 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0007 PF02865 STAT protein, protein interaction domain 0.0007 PF02864 STAT protein, DNA binding domain 0.0006 PF00206 Lyase 0.0005 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0004 PF01437 Plexin repeat 0.0004 PF00970 Oxidoreductase FAD-binding domain 0.0004 PF00571 CBS domain 0.0004 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0004 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0004 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0004 PF00489 Interleukin-6/G-CSF/MGF family 0.0004 PF01403 Sema domain 0.0004 PF00654 Voltage gated chloride channel 0.0004 PF01833 IPT/TIG domain 0.0004 PF00245 Alkaline phosphatase 0.0004 PF02441 Flavoprotein 0.0003 PF07678 A-macroglobulin complement component 0.0003 PF07677 A-macroglobulin receptor 0.0003 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0003 PF00069 Protein kinase domain 0.0003 PF00709 Adenylosuccinate synthetase 0.0003 PF00625 Guanylate kinase 0.0003 PF00405 Transferrin 0.0003 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0003 PF02607 B12 binding domain 0.0003 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0003 PF01835 MG2 domain 0.0003 PF00809 Pterin binding enzyme 0.0003 PF00117 Glutamine amidotransferase class-I 0.0003 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0003 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0003 PF00459 Inositol monophosphatase family 0.0003 PF02196 Raf-like Ras-binding domain 0.0003 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0003 PF08063 PADR1 (NUC008), domain 0.0003 PF00533 BRCA1 C Terminus (BRCT), domain 0.0003 PF05406 WGR domain 0.0003 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0002 PF07970 Endoplasmic reticulum vesicle transporter 0.0002 PF12126 Protein of unknown function (DUF3583), 0.0002 PF01180 Dihydroorotate dehydrogenase 0.0002 PF00134 Cyclin, N-terminal domain 0.0002 PF00310 Glutamine amidotransferases class-II 0.0002 PF03454 MoeA C-terminal region (domain IV), 0.0002 PF03453 MoeA N-terminal region (domain I and II), 0.0002 PF00431 CUB domain 0.0002 PF00994 Probable molybdopterin binding domain 0.0002 PF08399 VWA N-terminal 0.0002 PF02828 L27 domain 0.0002 PF00779 BTK motif 0.0002 PF00089 Trypsin 0.0002 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0002 PF02743 Cache domain 0.0002 PF00514 Armadillo/beta-catenin-like repeat 0.0002 PF02984 Cyclin, C-terminal domain 0.0001 PF00041 Fibronectin type III domain 0.0001 PF00042 Globin 0.0001 PF05193 Peptidase M16 inactive domain 0.0001 PF00989 PAS fold 0.0001 PF00027 Cyclic nucleotide-binding domain 0.0001 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0001 PF01369 Sec7 domain 0.0001 PF07653 Variant SH3 domain 0.0001 PF01733 Nucleoside transporter 0.0001 PF00406 Adenylate kinase 0.0001 PF08763 Voltage gated calcium channel IQ domain 0.0001 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0001 PF02189 Immunoreceptor tyrosine-based activation motif 0.0001 PF00675 Insulinase (Peptidase family M16), SUB366 C(~H)(~N) 0.2021 PF00001 7 transmembrane receptor (rhodopsin family), 0.0806 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0666 PF00209 Sodium:neurotransmitter symporter family 0.0479 PF03073 TspO/MBR family 0.0393 PF01401 Angiotensin-converting enzyme 0.0286 PF00005 ABC transporter 0.0246 PF00664 ABC transporter transmembrane region 0.0234 PF00989 PAS fold 0.0207 PF00186 Dihydrofolate reductase 0.0197 PF00027 Cyclic nucleotide-binding domain 0.0194 PF02223 Thymidylate kinase 0.0166 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0160 PF01048 Phosphorylase superfamily 0.0136 PF00069 Protein kinase domain 0.0130 PF06512 Sodium ion transport-associated 0.0119 PF05649 Peptidase family M13 0.0119 PF01431 Peptidase family M13 0.0101 PF00520 Ion transport protein 0.0092 PF00017 SH2 domain 0.0090 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0090 PF02180 Bcl-2 homology region 4 0.0082 PF08983 Domain of unknown function (DUF1856), 0.0082 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0082 PF02267 ADP-ribosyl cyclase 0.0072 PF01007 Inward rectifier potassium channel 0.0052 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0047 PF01842 ACT domain 0.0047 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0045 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0045 PF00464 Serine hydroxymethyltransferase 0.0039 PF01061 ABC-2 type transporter 0.0038 PF01467 Cytidylyltransferase 0.0037 PF00018 SH3 domain 0.0037 PF00255 Glutathione peroxidase 0.0035 PF02798 Glutathione S-transferase, N-terminal domain 0.0035 PF00303 Thymidylate synthase 0.0033 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0033 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0032 PF08919 F-actin binding 0.0032 PF01234 NNMT/PNMT/TEMT family 0.0028 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0028 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0028 PF00043 Glutathione S-transferase, C-terminal domain 0.0022 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0020 PF01590 GAF domain 0.0018 PF03807 NADP oxidoreductase coenzyme F420-dependent 0.0018 PF00551 Formyl transferase 0.0016 PF08491 Squalene epoxidase 0.0011 PF08441 Integrin alpha 0.0011 PF00088 Trefoil (P-type), domain 0.0011 PF01055 Glycosyl hydrolases family 31 0.0009 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0009 PF09396 Thrombin light chain 0.0008 PF01808 AICARFT/IMPCHase bienzyme 0.0008 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0008 PF02173 pKID domain 0.0008 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0008 PF01687 Riboflavin kinase 0.0008 PF07966 A1 Propeptide 0.0008 PF08063 PADR1 (NUC008), domain 0.0008 PF05406 WGR domain 0.0008 PF00533 BRCA1 C Terminus (BRCT), domain 0.0008 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0007 PF08403 Amino acid permease N-terminal 0.0006 PF06464 DMAP1-binding Domain 0.0006 PF02008 CXXC zinc finger domain 0.0006 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0006 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0006 PF00357 Integrin alpha cytoplasmic region 0.0006 PF01571 Aminomethyltransferase folate-binding domain 0.0006 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0006 PF00026 Eukaryotic aspartyl protease 0.0006 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0006 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0006 PF01426 BAH domain 0.0006 PF01122 Eukaryotic cobalamin-binding protein 0.0003 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0003 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0002 PF08070 DTHCT (NUC029), region 0.0002 PF00204 DNA gyrase B 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0001 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0001 PF00755 Choline/Carnitine o-acyltransferase SUB589 O=C-C-C=O 0.2016 PF08070 DTHCT (NUC029), region 0.2016 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.2016 PF00204 DNA gyrase B 0.0916 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0251 PF00273 Serum albumin family 0.0230 PF00091 Tubulin/FtsZ family, GTPase domain 0.0230 PF03953 Tubulin C-terminal domain 0.0178 PF00102 Protein-tyrosine phosphatase 0.0171 PF00576 HIUase/Transthyretin family 0.0129 PF00405 Transferrin 0.0129 PF00005 ABC transporter 0.0128 PF09396 Thrombin light chain 0.0121 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0115 PF01061 ABC-2 type transporter 0.0094 PF07884 Vitamin K epoxide reductase family 0.0092 PF00664 ABC transporter transmembrane region 0.0086 PF00754 F5/8 type C domain 0.0081 PF00017 SH2 domain 0.0079 PF08919 F-actin binding 0.0074 PF03098 Animal haem peroxidase 0.0070 PF01735 Lysophospholipase catalytic domain 0.0069 PF00018 SH3 domain 0.0067 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0059 PF01187 Macrophage migration inhibitory factor (MIF), 0.0059 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0056 PF00305 Lipoxygenase 0.0055 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0054 PF03957 Jun-like transcription factor 0.0054 PF00079 Serpin (serine protease inhibitor), 0.0052 PF03171 2OG-Fe(II), oxygenase superfamily 0.0052 PF00291 Pyridoxal-phosphate dependent enzyme 0.0049 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0047 PF01477 PLAT/LH2 domain 0.0047 PF00656 Caspase domain 0.0046 PF00266 Aminotransferase class-V 0.0045 PF00390 Malic enzyme, N-terminal domain 0.0045 PF03949 Malic enzyme, NAD binding domain 0.0045 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0044 PF00168 C2 domain 0.0044 PF02260 FATC domain 0.0044 PF02155 Glucocorticoid receptor 0.0044 PF08771 Rapamycin binding domain 0.0044 PF00043 Glutathione S-transferase, C-terminal domain 0.0044 PF02259 FAT domain 0.0042 PF02798 Glutathione S-transferase, N-terminal domain 0.0041 PF00493 MCM2/3/5 family 0.0040 PF00340 Interleukin-1 / 18 0.0040 PF02394 Interleukin-1 propeptide 0.0040 PF00229 TNF(Tumour Necrosis Factor), family 0.0038 PF00341 Platelet-derived growth factor (PDGF), 0.0038 PF01023 S-100/ICaBP type calcium binding domain 0.0038 PF01347 Lipoprotein amino terminal region 0.0036 PF01180 Dihydroorotate dehydrogenase 0.0034 PF00108 Thiolase, N-terminal domain 0.0034 PF02803 Thiolase, C-terminal domain 0.0034 PF00155 Aminotransferase class I and II 0.0033 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0033 PF00271 Helicase conserved C-terminal domain 0.0033 PF00040 Fibronectin type II domain 0.0033 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0033 PF00698 Acyl transferase domain 0.0033 PF00975 Thioesterase domain 0.0033 PF08659 KR domain 0.0032 PF00989 PAS fold 0.0032 PF00085 Thioredoxin 0.0032 PF00377 Prion/Doppel alpha-helical domain 0.0031 PF01202 Shikimate kinase 0.0031 PF00071 Ras family 0.0031 PF00170 bZIP transcription factor 0.0030 PF00002 7 transmembrane receptor (Secretin family), 0.0030 PF02059 Interleukin-3 0.0030 PF02793 Hormone receptor domain 0.0029 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0029 PF12491 Apolipoprotein B100 C terminal 0.0029 PF00191 Annexin 0.0029 PF06448 Domain of Unknown Function (DUF1081), 0.0029 PF00176 SNF2 family N-terminal domain 0.0028 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0027 PF00755 Choline/Carnitine o-acyltransferase 0.0027 PF01391 Collagen triple helix repeat (20 copies), 0.0026 PF03062 MBOAT family 0.0025 PF00027 Cyclic nucleotide-binding domain 0.0025 PF02525 Flavodoxin-like fold 0.0024 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0024 PF00058 Low-density lipoprotein receptor repeat class B 0.0024 PF04679 ATP dependent DNA ligase C terminal region 0.0024 PF01068 ATP dependent DNA ligase domain 0.0023 PF02824 TGS domain 0.0023 PF00781 Diacylglycerol kinase catalytic domain 0.0023 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0023 PF02180 Bcl-2 homology region 4 0.0023 PF01731 Arylesterase 0.0023 PF03034 Phosphatidyl serine synthase 0.0023 PF02025 Interleukin 5 0.0023 PF00094 von Willebrand factor type D domain 0.0023 PF00609 Diacylglycerol kinase accessory domain 0.0023 PF08742 C8 domain 0.0023 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0022 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0022 PF02928 C5HC2 zinc finger 0.0022 PF00342 Phosphoglucose isomerase 0.0022 PF08429 PLU-1-like protein 0.0022 PF02375 jmjN domain 0.0022 PF00274 Fructose-bisphosphate aldolase class-I 0.0022 PF01388 ARID/BRIGHT DNA binding domain 0.0022 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0022 PF02373 JmjC domain 0.0022 PF00183 Hsp90 protein 0.0022 PF00860 Permease family 0.0022 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0022 PF01753 MYND finger 0.0022 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0022 PF00628 PHD-finger 0.0021 PF01596 O-methyltransferase 0.0020 PF00057 Low-density lipoprotein receptor domain class A 0.0020 PF00464 Serine hydroxymethyltransferase 0.0019 PF00343 Carbohydrate phosphorylase 0.0019 PF01429 Methyl-CpG binding domain 0.0019 PF01425 Amidase 0.0018 PF03476 MOSC N-terminal beta barrel domain 0.0018 PF03473 MOSC domain 0.0018 PF00654 Voltage gated chloride channel 0.0018 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0018 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0017 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0017 PF01833 IPT/TIG domain 0.0017 PF01437 Plexin repeat 0.0017 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0017 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0017 PF01403 Sema domain 0.0017 PF00717 Peptidase S24-like 0.0017 PF03351 DOMON domain 0.0017 PF00186 Dihydrofolate reductase 0.0016 PF07647 SAM domain (Sterile alpha motif), 0.0016 PF00550 Phosphopantetheine attachment site 0.0016 PF00969 Class II histocompatibility antigen, beta domain 0.0016 PF00554 Rel homology domain (RHD), 0.0016 PF00246 Zinc carboxypeptidase 0.0016 PF11404 Potassium voltage-gated channel 0.0016 PF00270 DEAD/DEAH box helicase 0.0016 PF09193 Cholecystokinin A receptor, N-terminal 0.0016 PF02666 Phosphatidylserine decarboxylase 0.0016 PF01130 CD36 family 0.0016 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0016 PF02403 Seryl-tRNA synthetase N-terminal domain 0.0016 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0015 PF00051 Kringle domain 0.0015 PF03623 Focal adhesion targeting region 0.0014 PF02898 Nitric oxide synthase, oxygenase domain 0.0013 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.0013 PF00294 pfkB family carbohydrate kinase 0.0013 PF03360 Glycosyltransferase family 43 0.0012 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0012 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0011 PF01212 Beta-eliminating lyase 0.0011 PF01168 Alanine racemase, N-terminal domain 0.0011 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0011 PF07690 Major Facilitator Superfamily 0.0011 PF02347 Glycine cleavage system P-protein 0.0010 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 0.0010 PF00373 FERM central domain 0.0009 PF00020 TNFR/NGFR cysteine-rich region 0.0009 PF00489 Interleukin-6/G-CSF/MGF family 0.0009 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0009 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0009 PF00028 Cadherin domain 0.0009 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0009 PF00714 Interferon gamma 0.0009 PF00688 TGF-beta propeptide 0.0009 PF00019 Transforming growth factor beta like domain 0.0009 PF00151 Lipase 0.0008 PF00682 HMGL-like 0.0007 PF01462 Leucine rich repeat N-terminal domain 0.0007 PF00202 Aminotransferase class-III 0.0007 PF05406 WGR domain 0.0007 PF08063 PADR1 (NUC008), domain 0.0007 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0007 PF00533 BRCA1 C Terminus (BRCT), domain 0.0007 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0006 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0005 PF00619 Caspase recruitment domain 0.0005 PF03129 Anticodon binding domain 0.0005 PF00571 CBS domain 0.0005 PF00787 PX domain 0.0005 PF04961 Formiminotransferase-cyclodeaminase 0.0005 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0005 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0005 PF02971 Formiminotransferase domain 0.0005 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0005 PF00432 Prenyltransferase and squalene oxidase repeat 0.0005 PF02460 Patched family 0.0004 PF00794 PI3-kinase family, ras-binding domain 0.0004 PF00792 Phosphoinositide 3-kinase C2 0.0004 PF00354 Pentaxin family 0.0004 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0004 PF00648 Calpain family cysteine protease 0.0004 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0004 PF01067 Calpain large subunit, domain III 0.0004 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0004 PF00622 SPRY domain 0.0004 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0004 PF00024 PAN domain 0.0004 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0003 PF08454 RyR and IP3R Homology associated 0.0003 PF07648 Kazal-type serine protease inhibitor domain 0.0003 PF02026 RyR domain 0.0003 PF04756 OST3 / OST6 family 0.0003 PF01365 RIH domain 0.0003 PF00227 Proteasome subunit 0.0003 PF02210 Laminin G domain 0.0003 PF03024 Folate receptor family 0.0003 PF02815 MIR domain 0.0003 PF00433 Protein kinase C terminal domain 0.0003 PF00074 Pancreatic ribonuclease 0.0003 PF08709 Inositol 1,4,5-trisphosphate/ryanodine receptor 0.0003 PF02758 PAAD/DAPIN/Pyrin domain 0.0003 PF06459 Ryanodine Receptor TM 4-6 0.0003 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0002 PF00025 ADP-ribosylation factor family 0.0002 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0002 PF00067 Cytochrome P450 0.0001 PF00675 Insulinase (Peptidase family M16), 0.0001 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0001 PF00531 Death domain 0.0001 PF05193 Peptidase M16 inactive domain 0.0001 PF08725 Integrin beta cytoplasmic domain 0.0001 PF00089 Trypsin SUB517 [#1]-C=C-[#1] 0.2009 PF00001 7 transmembrane receptor (rhodopsin family), 0.0855 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0828 PF03098 Animal haem peroxidase 0.0748 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0746 PF00105 Zinc finger, C4 type (two domains), 0.0706 PF02159 Oestrogen receptor 0.0517 PF00209 Sodium:neurotransmitter symporter family 0.0403 PF06512 Sodium ion transport-associated 0.0270 PF03073 TspO/MBR family 0.0226 PF09396 Thrombin light chain 0.0190 PF00005 ABC transporter 0.0187 PF00191 Annexin 0.0185 PF00989 PAS fold 0.0157 PF00067 Cytochrome P450 0.0155 PF00520 Ion transport protein 0.0154 PF00664 ABC transporter transmembrane region 0.0148 PF00027 Cyclic nucleotide-binding domain 0.0109 PF02155 Glucocorticoid receptor 0.0089 PF01593 Flavin containing amine oxidoreductase 0.0088 PF02161 Progesterone receptor 0.0063 PF00186 Dihydrofolate reductase 0.0060 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0046 PF01007 Inward rectifier potassium channel 0.0026 PF01735 Lysophospholipase catalytic domain 0.0023 PF11825 Protein of unknown function (DUF3345), 0.0020 PF00017 SH2 domain 0.0016 PF12497 Estrogen receptor beta SUB736 Cc1cc(O)ccc1 0.1997 PF02159 Oestrogen receptor 0.1054 PF00001 7 transmembrane receptor (rhodopsin family), 0.0864 PF00105 Zinc finger, C4 type (two domains), 0.0843 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0806 PF00204 DNA gyrase B 0.0806 PF08070 DTHCT (NUC029), region 0.0806 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0403 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0391 PF12497 Estrogen receptor beta 0.0390 PF00576 HIUase/Transthyretin family 0.0314 PF00976 Corticotropin ACTH domain 0.0314 PF08035 Opioids neuropeptide 0.0314 PF08384 Pro-opiomelanocortin, N-terminal region 0.0300 PF00102 Protein-tyrosine phosphatase 0.0294 PF00989 PAS fold 0.0291 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0240 PF00027 Cyclic nucleotide-binding domain 0.0234 PF00005 ABC transporter 0.0231 PF00664 ABC transporter transmembrane region 0.0196 PF11825 Protein of unknown function (DUF3345), 0.0164 PF00643 B-box zinc finger 0.0152 PF01596 O-methyltransferase 0.0112 PF01477 PLAT/LH2 domain 0.0110 PF00305 Lipoxygenase 0.0105 PF03062 MBOAT family 0.0105 PF00340 Interleukin-1 / 18 0.0105 PF02394 Interleukin-1 propeptide 0.0088 PF08983 Domain of unknown function (DUF1856), 0.0063 PF04622 ERG2 and Sigma1 receptor like protein 0.0056 PF00656 Caspase domain 0.0056 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0054 PF01160 Vertebrate endogenous opioids neuropeptide 0.0054 PF00183 Hsp90 protein 0.0054 PF00918 Gastrin/cholecystokinin family 0.0037 PF01180 Dihydroorotate dehydrogenase 0.0037 PF01588 Putative tRNA binding domain 0.0035 PF00135 Carboxylesterase 0.0034 PF03765 CRAL/TRIO, N-terminus 0.0034 PF00650 CRAL/TRIO domain 0.0034 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0034 PF08377 MAP2/Tau projection domain 0.0034 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0034 PF02180 Bcl-2 homology region 4 0.0033 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0033 PF02460 Patched family 0.0032 PF00377 Prion/Doppel alpha-helical domain 0.0031 PF06327 Domain of Unknown Function (DUF1053), 0.0031 PF00884 Sulfatase 0.0031 PF08441 Integrin alpha 0.0028 PF00625 Guanylate kinase 0.0026 PF00357 Integrin alpha cytoplasmic region 0.0026 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0020 PF07885 Ion channel 0.0020 PF09396 Thrombin light chain 0.0017 PF00229 TNF(Tumour Necrosis Factor), family 0.0015 PF00341 Platelet-derived growth factor (PDGF), 0.0014 PF00002 7 transmembrane receptor (Secretin family), 0.0014 PF08763 Voltage gated calcium channel IQ domain 0.0014 PF02793 Hormone receptor domain 0.0013 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0013 PF00094 von Willebrand factor type D domain 0.0013 PF08742 C8 domain 0.0013 PF02201 SWIB/MDM2 domain 0.0013 PF02025 Interleukin 5 0.0013 PF09193 Cholecystokinin A receptor, N-terminal 0.0013 PF00641 Zn-finger in Ran binding protein and others 0.0012 PF00170 bZIP transcription factor 0.0011 PF00068 Phospholipase A2 0.0009 PF03953 Tubulin C-terminal domain 0.0009 PF00266 Aminotransferase class-V 0.0009 PF00091 Tubulin/FtsZ family, GTPase domain 0.0009 PF00757 Furin-like cysteine rich region 0.0009 PF01030 Receptor L domain 0.0008 PF01733 Nucleoside transporter 0.0008 PF00620 RhoGAP domain 0.0008 PF02173 pKID domain 0.0006 PF01347 Lipoprotein amino terminal region 0.0004 PF00151 Lipase SUB137 >= 2 any ring size 4 0.1993 PF02984 Cyclin, C-terminal domain 0.1993 PF12126 Protein of unknown function (DUF3583), 0.1993 PF00134 Cyclin, N-terminal domain 0.1993 PF07970 Endoplasmic reticulum vesicle transporter 0.1988 PF12179 I-kappa-kinase-beta NEMO binding domain 0.1985 PF00489 Interleukin-6/G-CSF/MGF family 0.1982 PF03957 Jun-like transcription factor 0.1373 PF00170 bZIP transcription factor 0.1176 PF00689 Cation transporting ATPase, C-terminus 0.1176 PF00690 Cation transporter/ATPase, N-terminus 0.1110 PF00643 B-box zinc finger 0.1091 PF00069 Protein kinase domain 0.1041 PF00122 E1-E2 ATPase 0.0933 PF00702 haloacid dehalogenase-like hydrolase 0.0769 PF00433 Protein kinase C terminal domain 0.0508 PF00169 PH domain 0.0504 PF00664 ABC transporter transmembrane region 0.0412 PF00005 ABC transporter 0.0281 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0276 PF00146 NADH dehydrogenase 0.0272 PF01161 Phosphatidylethanolamine-binding protein 0.0241 PF00459 Inositol monophosphatase family 0.0211 PF00405 Transferrin 0.0191 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0188 PF00194 Eukaryotic-type carbonic anhydrase 0.0167 PF03160 Calx-beta domain 0.0150 PF00581 Rhodanese-like domain 0.0150 PF06617 M-phase inducer phosphatase 0.0147 PF00324 Amino acid permease 0.0145 PF02214 K+ channel tetramerisation domain 0.0143 PF00625 Guanylate kinase 0.0130 PF00514 Armadillo/beta-catenin-like repeat 0.0126 PF00576 HIUase/Transthyretin family 0.0103 PF03453 MoeA N-terminal region (domain I and II), 0.0103 PF00994 Probable molybdopterin binding domain 0.0103 PF03454 MoeA C-terminal region (domain IV), 0.0103 PF02828 L27 domain 0.0100 PF01369 Sec7 domain 0.0093 PF00822 PMP-22/EMP/MP20/Claudin family 0.0091 PF08403 Amino acid permease N-terminal 0.0090 PF00362 Integrin, beta chain 0.0090 PF07965 Integrin beta tail domain 0.0082 PF00248 Aldo/keto reductase family 0.0081 PF02867 Ribonucleotide reductase, barrel domain 0.0081 PF00317 Ribonucleotide reductase, all-alpha domain 0.0081 PF03477 ATP cone domain 0.0080 PF00211 Adenylate and Guanylate cyclase catalytic domain 0.0068 PF00273 Serum albumin family 0.0066 PF00107 Zinc-binding dehydrogenase 0.0064 PF08240 Alcohol dehydrogenase GroES-like domain 0.0060 PF03949 Malic enzyme, NAD binding domain 0.0060 PF00041 Fibronectin type III domain 0.0060 PF00390 Malic enzyme, N-terminal domain 0.0056 PF00854 POT family 0.0051 PF07653 Variant SH3 domain 0.0050 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0050 PF02743 Cache domain 0.0050 PF08399 VWA N-terminal 0.0043 PF08763 Voltage gated calcium channel IQ domain 0.0041 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0041 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0026 PF00595 PDZ domain (Also known as DHR or GLGF), 0.0023 PF00167 Fibroblast growth factor 0.0020 PF00153 Mitochondrial carrier protein 0.0020 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0020 PF00631 GGL domain 0.0020 PF00821 Phosphoenolpyruvate carboxykinase 0.0019 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0017 PF02180 Bcl-2 homology region 4 0.0017 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0015 PF00858 Amiloride-sensitive sodium channel 0.0013 PF09127 Leukotriene A4 hydrolase, C-terminal 0.0012 PF08674 Acetylcholinesterase tetramerisation domain 0.0009 PF03530 Calcium-activated SK potassium channel 0.0009 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0009 PF02254 TrkA-N domain 0.0009 PF02888 Calmodulin binding domain 0.0004 PF00303 Thymidylate synthase 0.0001 PF00156 Phosphoribosyl transferase domain SUB140 >= 2 saturated or aromatic heteroatom-containing ring size 4 0.1993 PF07970 Endoplasmic reticulum vesicle transporter 0.1993 PF02984 Cyclin, C-terminal domain 0.1993 PF12126 Protein of unknown function (DUF3583), 0.1993 PF00134 Cyclin, N-terminal domain 0.1988 PF12179 I-kappa-kinase-beta NEMO binding domain 0.1985 PF00489 Interleukin-6/G-CSF/MGF family 0.1982 PF03957 Jun-like transcription factor 0.1373 PF00170 bZIP transcription factor 0.1176 PF00690 Cation transporter/ATPase, N-terminus 0.1176 PF00689 Cation transporting ATPase, C-terminus 0.1110 PF00643 B-box zinc finger 0.1091 PF00069 Protein kinase domain 0.1041 PF00122 E1-E2 ATPase 0.0933 PF00702 haloacid dehalogenase-like hydrolase 0.0769 PF00433 Protein kinase C terminal domain 0.0508 PF00169 PH domain 0.0504 PF00664 ABC transporter transmembrane region 0.0412 PF00005 ABC transporter 0.0281 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0276 PF00146 NADH dehydrogenase 0.0272 PF01161 Phosphatidylethanolamine-binding protein 0.0241 PF00459 Inositol monophosphatase family 0.0211 PF00405 Transferrin 0.0191 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0188 PF00194 Eukaryotic-type carbonic anhydrase 0.0167 PF03160 Calx-beta domain 0.0150 PF00581 Rhodanese-like domain 0.0150 PF06617 M-phase inducer phosphatase 0.0147 PF00324 Amino acid permease 0.0145 PF02214 K+ channel tetramerisation domain 0.0143 PF00625 Guanylate kinase 0.0130 PF00514 Armadillo/beta-catenin-like repeat 0.0126 PF00576 HIUase/Transthyretin family 0.0103 PF00994 Probable molybdopterin binding domain 0.0103 PF02828 L27 domain 0.0103 PF03453 MoeA N-terminal region (domain I and II), 0.0103 PF03454 MoeA C-terminal region (domain IV), 0.0100 PF01369 Sec7 domain 0.0093 PF00822 PMP-22/EMP/MP20/Claudin family 0.0091 PF08403 Amino acid permease N-terminal 0.0090 PF00362 Integrin, beta chain 0.0090 PF07965 Integrin beta tail domain 0.0082 PF00248 Aldo/keto reductase family 0.0081 PF03477 ATP cone domain 0.0081 PF02867 Ribonucleotide reductase, barrel domain 0.0081 PF00317 Ribonucleotide reductase, all-alpha domain 0.0080 PF00211 Adenylate and Guanylate cyclase catalytic domain 0.0068 PF00273 Serum albumin family 0.0066 PF00107 Zinc-binding dehydrogenase 0.0064 PF08240 Alcohol dehydrogenase GroES-like domain 0.0060 PF00041 Fibronectin type III domain 0.0060 PF00390 Malic enzyme, N-terminal domain 0.0060 PF03949 Malic enzyme, NAD binding domain 0.0056 PF00854 POT family 0.0051 PF07653 Variant SH3 domain 0.0050 PF08399 VWA N-terminal 0.0050 PF02743 Cache domain 0.0050 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0043 PF08763 Voltage gated calcium channel IQ domain 0.0041 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0041 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0026 PF00595 PDZ domain (Also known as DHR or GLGF), 0.0023 PF00167 Fibroblast growth factor 0.0020 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0020 PF00153 Mitochondrial carrier protein 0.0020 PF00631 GGL domain 0.0020 PF00821 Phosphoenolpyruvate carboxykinase 0.0019 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0017 PF02180 Bcl-2 homology region 4 0.0017 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0015 PF00858 Amiloride-sensitive sodium channel 0.0013 PF09127 Leukotriene A4 hydrolase, C-terminal 0.0012 PF08674 Acetylcholinesterase tetramerisation domain 0.0009 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0009 PF03530 Calcium-activated SK potassium channel 0.0009 PF02254 TrkA-N domain 0.0009 PF02888 Calmodulin binding domain 0.0004 PF00303 Thymidylate synthase 0.0001 PF00156 Phosphoribosyl transferase domain SUB711 C-C-C(C)-C-C 0.1963 PF00001 7 transmembrane receptor (rhodopsin family), 0.1645 PF02159 Oestrogen receptor 0.1380 PF00105 Zinc finger, C4 type (two domains), 0.1374 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1093 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0845 PF00204 DNA gyrase B 0.0845 PF08070 DTHCT (NUC029), region 0.0845 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0709 PF00209 Sodium:neurotransmitter symporter family 0.0581 PF03098 Animal haem peroxidase 0.0484 PF06512 Sodium ion transport-associated 0.0445 PF02161 Progesterone receptor 0.0416 PF00191 Annexin 0.0397 PF09396 Thrombin light chain 0.0365 PF00520 Ion transport protein 0.0311 PF02155 Glucocorticoid receptor 0.0300 PF00989 PAS fold 0.0262 PF03073 TspO/MBR family 0.0237 PF00067 Cytochrome P450 0.0225 PF00027 Cyclic nucleotide-binding domain 0.0211 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0207 PF02166 Androgen receptor 0.0146 PF00091 Tubulin/FtsZ family, GTPase domain 0.0146 PF03953 Tubulin C-terminal domain 0.0116 PF01735 Lysophospholipase catalytic domain 0.0111 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0111 PF00005 ABC transporter 0.0110 PF00102 Protein-tyrosine phosphatase 0.0101 PF12497 Estrogen receptor beta 0.0078 PF00186 Dihydrofolate reductase 0.0064 PF00664 ABC transporter transmembrane region 0.0064 PF00305 Lipoxygenase 0.0008 PF07884 Vitamin K epoxide reductase family SUB694 O=C-C-C-C-C-O 0.1957 PF00191 Annexin 0.1700 PF02155 Glucocorticoid receptor 0.0936 PF01735 Lysophospholipase catalytic domain 0.0908 PF00079 Serpin (serine protease inhibitor), 0.0602 PF02798 Glutathione S-transferase, N-terminal domain 0.0589 PF00043 Glutathione S-transferase, C-terminal domain 0.0572 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0569 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0559 PF00105 Zinc finger, C4 type (two domains), 0.0531 PF00204 DNA gyrase B 0.0531 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0531 PF08070 DTHCT (NUC029), region 0.0467 PF03953 Tubulin C-terminal domain 0.0467 PF00091 Tubulin/FtsZ family, GTPase domain 0.0357 PF00255 Glutathione peroxidase 0.0352 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0347 PF00168 C2 domain 0.0287 PF05649 Peptidase family M13 0.0287 PF01431 Peptidase family M13 0.0283 PF00102 Protein-tyrosine phosphatase 0.0250 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0217 PF00557 Metallopeptidase family M24 0.0202 PF01124 MAPEG family 0.0200 PF02180 Bcl-2 homology region 4 0.0200 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0179 PF00656 Caspase domain 0.0173 PF01401 Angiotensin-converting enzyme 0.0172 PF00554 Rel homology domain (RHD), 0.0163 PF09396 Thrombin light chain 0.0158 PF03199 Eukaryotic glutathione synthase 0.0158 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0153 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0149 PF00183 Hsp90 protein 0.0148 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0146 PF00229 TNF(Tumour Necrosis Factor), family 0.0122 PF12497 Estrogen receptor beta 0.0121 PF08035 Opioids neuropeptide 0.0121 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0121 PF00976 Corticotropin ACTH domain 0.0121 PF08384 Pro-opiomelanocortin, N-terminal region 0.0120 PF01323 DSBA-like thioredoxin domain 0.0115 PF03062 MBOAT family 0.0112 PF02173 pKID domain 0.0106 PF08983 Domain of unknown function (DUF1856), 0.0101 PF00303 Thymidylate synthase 0.0100 PF01477 PLAT/LH2 domain 0.0095 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0095 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0093 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0091 PF07690 Major Facilitator Superfamily 0.0088 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0087 PF00462 Glutaredoxin 0.0087 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0082 PF02159 Oestrogen receptor 0.0082 PF07722 Peptidase C26 0.0078 PF00170 bZIP transcription factor 0.0076 PF00005 ABC transporter 0.0072 PF01406 tRNA synthetases class I (C), catalytic domain 0.0069 PF01019 Gamma-glutamyltranspeptidase 0.0069 PF00756 Putative esterase 0.0069 PF05995 Cysteine dioxygenase type I 0.0069 PF00664 ABC transporter transmembrane region 0.0068 PF01347 Lipoprotein amino terminal region 0.0068 PF00151 Lipase 0.0066 PF02259 FAT domain 0.0066 PF02260 FATC domain 0.0066 PF08771 Rapamycin binding domain 0.0062 PF03171 2OG-Fe(II), oxygenase superfamily 0.0061 PF00341 Platelet-derived growth factor (PDGF), 0.0061 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0061 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0059 PF00619 Caspase recruitment domain 0.0058 PF00531 Death domain 0.0057 PF03074 Glutamate-cysteine ligase 0.0055 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0052 PF07648 Kazal-type serine protease inhibitor domain 0.0049 PF02525 Flavodoxin-like fold 0.0048 PF02025 Interleukin 5 0.0048 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0048 PF00094 von Willebrand factor type D domain 0.0048 PF08742 C8 domain 0.0046 PF00305 Lipoxygenase 0.0045 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0045 PF00176 SNF2 family N-terminal domain 0.0043 PF00271 Helicase conserved C-terminal domain 0.0041 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0041 PF00975 Thioesterase domain 0.0041 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0041 PF00698 Acyl transferase domain 0.0041 PF08659 KR domain 0.0039 PF00439 Bromodomain 0.0039 PF00432 Prenyltransferase and squalene oxidase repeat 0.0039 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0036 PF00493 MCM2/3/5 family 0.0035 PF06617 M-phase inducer phosphatase 0.0035 PF00581 Rhodanese-like domain 0.0032 PF01596 O-methyltransferase 0.0032 PF03002 Somatostatin/Cortistatin family 0.0031 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0030 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0028 PF02758 PAAD/DAPIN/Pyrin domain 0.0027 PF00085 Thioredoxin 0.0026 PF00342 Phosphoglucose isomerase 0.0026 PF01391 Collagen triple helix repeat (20 copies), 0.0026 PF00806 Pumilio-family RNA binding repeat 0.0026 PF08833 Axin beta-catenin binding domain 0.0026 PF00778 DIX domain 0.0025 PF00023 Ankyrin repeat 0.0025 PF00822 PMP-22/EMP/MP20/Claudin family 0.0023 PF02887 Pyruvate kinase, alpha/beta domain 0.0023 PF00224 Pyruvate kinase, barrel domain 0.0023 PF00265 Thymidine kinase 0.0022 PF00377 Prion/Doppel alpha-helical domain 0.0022 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0022 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0022 PF03360 Glycosyltransferase family 43 0.0021 PF02166 Androgen receptor 0.0021 PF00167 Fibroblast growth factor 0.0021 PF00489 Interleukin-6/G-CSF/MGF family 0.0021 PF00040 Fibronectin type II domain 0.0019 PF00931 NB-ARC domain 0.0019 PF00400 WD domain, G-beta repeat 0.0018 PF00274 Fructose-bisphosphate aldolase class-I 0.0017 PF07884 Vitamin K epoxide reductase family 0.0017 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0016 PF00340 Interleukin-1 / 18 0.0016 PF02460 Patched family 0.0016 PF00354 Pentaxin family 0.0016 PF02394 Interleukin-1 propeptide 0.0015 PF01061 ABC-2 type transporter 0.0014 PF00002 7 transmembrane receptor (Secretin family), 0.0014 PF02793 Hormone receptor domain 0.0013 PF00969 Class II histocompatibility antigen, beta domain 0.0013 PF00071 Ras family 0.0013 PF02161 Progesterone receptor 0.0013 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0012 PF06448 Domain of Unknown Function (DUF1081), 0.0012 PF12491 Apolipoprotein B100 C terminal 0.0012 PF03623 Focal adhesion targeting region 0.0011 PF00622 SPRY domain 0.0010 PF01268 Formate--tetrahydrofolate ligase 0.0010 PF00643 B-box zinc finger 0.0010 PF01023 S-100/ICaBP type calcium binding domain 0.0008 PF00067 Cytochrome P450 0.0008 PF00074 Pancreatic ribonuclease 0.0006 PF00586 AIR synthase related protein, N-terminal domain 0.0006 PF10420 Cytokine interleukin-12p40 C-terminus 0.0006 PF02769 AIR synthase related protein, C-terminal domain 0.0005 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0005 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0003 PF02803 Thiolase, C-terminal domain 0.0003 PF00108 Thiolase, N-terminal domain 0.0003 PF00045 Hemopexin 0.0003 PF01471 Putative peptidoglycan binding domain 0.0003 PF00550 Phosphopantetheine attachment site 0.0001 PF02928 C5HC2 zinc finger 0.0001 PF00628 PHD-finger 0.0001 PF08429 PLU-1-like protein 0.0001 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0001 PF01753 MYND finger 0.0001 PF02375 jmjN domain 0.0001 PF02373 JmjC domain 0.0001 PF01388 ARID/BRIGHT DNA binding domain 0.0001 PF00860 Permease family 0.0001 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0001 PF00551 Formyl transferase SUB712 C-C(C)(C)-C-C 0.1945 PF00105 Zinc finger, C4 type (two domains), 0.1944 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1931 PF02159 Oestrogen receptor 0.1669 PF00191 Annexin 0.1569 PF02155 Glucocorticoid receptor 0.1371 PF02161 Progesterone receptor 0.1036 PF02166 Androgen receptor 0.0763 PF01735 Lysophospholipase catalytic domain 0.0630 PF00079 Serpin (serine protease inhibitor), 0.0523 PF08035 Opioids neuropeptide 0.0523 PF00976 Corticotropin ACTH domain 0.0523 PF08384 Pro-opiomelanocortin, N-terminal region 0.0354 PF03953 Tubulin C-terminal domain 0.0354 PF00091 Tubulin/FtsZ family, GTPase domain 0.0300 PF00168 C2 domain 0.0251 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0250 PF11825 Protein of unknown function (DUF3345), 0.0217 PF12497 Estrogen receptor beta 0.0139 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0137 PF00106 short chain dehydrogenase 0.0137 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0137 PF01429 Methyl-CpG binding domain 0.0125 PF00305 Lipoxygenase 0.0125 PF00643 B-box zinc finger 0.0125 PF07648 Kazal-type serine protease inhibitor domain 0.0110 PF00067 Cytochrome P450 0.0110 PF08491 Squalene epoxidase 0.0108 PF00040 Fibronectin type II domain 0.0102 PF06327 Domain of Unknown Function (DUF1053), 0.0099 PF02180 Bcl-2 homology region 4 0.0099 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0088 PF01122 Eukaryotic cobalamin-binding protein 0.0087 PF00918 Gastrin/cholecystokinin family 0.0086 PF00653 Inhibitor of Apoptosis domain 0.0084 PF01477 PLAT/LH2 domain 0.0078 PF04622 ERG2 and Sigma1 receptor like protein 0.0068 PF00212 Atrial natriuretic peptide 0.0068 PF00170 bZIP transcription factor 0.0067 PF00554 Rel homology domain (RHD), 0.0066 PF00031 Cystatin domain 0.0063 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0062 PF01160 Vertebrate endogenous opioids neuropeptide 0.0062 PF02173 pKID domain 0.0057 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0057 PF08377 MAP2/Tau projection domain 0.0057 PF00650 CRAL/TRIO domain 0.0057 PF03765 CRAL/TRIO, N-terminus 0.0056 PF00762 Ferrochelatase 0.0053 PF00656 Caspase domain 0.0053 PF03308 ArgK protein 0.0053 PF01923 Cobalamin adenosyltransferase 0.0053 PF01642 Methylmalonyl-CoA mutase 0.0040 PF00884 Sulfatase 0.0040 PF02310 B12 binding domain 0.0039 PF00377 Prion/Doppel alpha-helical domain 0.0037 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0035 PF00204 DNA gyrase B 0.0035 PF00625 Guanylate kinase 0.0035 PF00969 Class II histocompatibility antigen, beta domain 0.0035 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0035 PF08070 DTHCT (NUC029), region 0.0035 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0034 PF03572 Peptidase family S41 0.0034 PF06907 Latexin 0.0033 PF00531 Death domain 0.0032 PF00183 Hsp90 protein 0.0030 PF00341 Platelet-derived growth factor (PDGF), 0.0029 PF00340 Interleukin-1 / 18 0.0029 PF02394 Interleukin-1 propeptide 0.0027 PF08763 Voltage gated calcium channel IQ domain 0.0024 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0020 PF00714 Interferon gamma 0.0019 PF00489 Interleukin-6/G-CSF/MGF family 0.0018 PF00432 Prenyltransferase and squalene oxidase repeat 0.0017 PF00357 Integrin alpha cytoplasmic region 0.0016 PF03957 Jun-like transcription factor 0.0014 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0014 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0010 PF00020 TNFR/NGFR cysteine-rich region 0.0010 PF00019 Transforming growth factor beta like domain 0.0010 PF02803 Thiolase, C-terminal domain 0.0010 PF00108 Thiolase, N-terminal domain 0.0010 PF00688 TGF-beta propeptide 0.0010 PF00890 FAD binding domain 0.0009 PF00689 Cation transporting ATPase, C-terminus 0.0009 PF01244 Membrane dipeptidase (Peptidase family M19), 0.0009 PF00690 Cation transporter/ATPase, N-terminus 0.0009 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0009 PF01327 Polypeptide deformylase 0.0009 PF00439 Bromodomain 0.0008 PF00122 E1-E2 ATPase 0.0007 PF00702 haloacid dehalogenase-like hydrolase 0.0006 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0006 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0004 PF01607 Chitin binding Peritrophin-A domain 0.0004 PF00039 Fibronectin type I domain 0.0004 PF02898 Nitric oxide synthase, oxygenase domain 0.0004 PF00704 Glycosyl hydrolases family 18 0.0004 PF08441 Integrin alpha 0.0003 PF01425 Amidase 0.0003 PF00654 Voltage gated chloride channel 0.0003 PF09164 Vitamin D binding protein, domain III 0.0002 PF02038 ATP1G1/PLM/MAT8 family 0.0002 PF00258 Flavodoxin 0.0002 PF00667 FAD binding domain 0.0002 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0002 PF00175 Oxidoreductase NAD-binding domain 0.0002 PF07884 Vitamin K epoxide reductase family 0.0001 PF00023 Ankyrin repeat 0.0001 PF00229 TNF(Tumour Necrosis Factor), family 0.0001 PF04756 OST3 / OST6 family 0.0001 PF01593 Flavin containing amine oxidoreductase 0.0001 PF02210 Laminin G domain SUB132 >= 1 saturated or aromatic nitrogen-containing ring size 4 0.1942 PF00273 Serum albumin family 0.1267 PF12179 I-kappa-kinase-beta NEMO binding domain 0.1191 PF08534 Redoxin 0.0661 PF00854 POT family 0.0622 PF09396 Thrombin light chain 0.0488 PF08702 Fibrinogen alpha/beta chain family 0.0488 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0301 PF02180 Bcl-2 homology region 4 0.0301 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0278 PF12160 Fibrinogen alpha C domain 0.0266 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0245 PF00051 Kringle domain 0.0231 PF02460 Patched family 0.0229 PF01731 Arylesterase 0.0226 PF03062 MBOAT family 0.0212 PF00167 Fibroblast growth factor 0.0211 PF00151 Lipase 0.0187 PF01459 Eukaryotic porin 0.0171 PF00069 Protein kinase domain 0.0165 PF00079 Serpin (serine protease inhibitor), 0.0160 PF00089 Trypsin 0.0147 PF05649 Peptidase family M13 0.0147 PF01431 Peptidase family M13 0.0146 PF01401 Angiotensin-converting enzyme 0.0145 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0145 PF08659 KR domain 0.0145 PF00698 Acyl transferase domain 0.0145 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0145 PF00975 Thioesterase domain 0.0125 PF01477 PLAT/LH2 domain 0.0121 PF01433 Peptidase family M1 0.0101 PF00059 Lectin C-type domain 0.0083 PF00576 HIUase/Transthyretin family 0.0083 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0082 PF02146 Sir2 family 0.0080 PF00550 Phosphopantetheine attachment site 0.0080 PF00343 Carbohydrate phosphorylase 0.0070 PF00091 Tubulin/FtsZ family, GTPase domain 0.0070 PF03953 Tubulin C-terminal domain 0.0069 PF07970 Endoplasmic reticulum vesicle transporter 0.0069 PF00134 Cyclin, N-terminal domain 0.0069 PF12126 Protein of unknown function (DUF3583), 0.0069 PF02984 Cyclin, C-terminal domain 0.0068 PF00024 PAN domain 0.0067 PF00405 Transferrin 0.0063 PF03957 Jun-like transcription factor 0.0063 PF00489 Interleukin-6/G-CSF/MGF family 0.0059 PF07645 Calcium-binding EGF domain 0.0056 PF02423 Ornithine cyclodeaminase/mu-crystallin family 0.0051 PF00664 ABC transporter transmembrane region 0.0039 PF00170 bZIP transcription factor 0.0039 PF00005 ABC transporter 0.0036 PF00107 Zinc-binding dehydrogenase 0.0036 PF02806 Alpha amylase, C-terminal all-beta domain 0.0035 PF00689 Cation transporting ATPase, C-terminus 0.0035 PF00690 Cation transporter/ATPase, N-terminus 0.0034 PF00643 B-box zinc finger 0.0031 PF00122 E1-E2 ATPase 0.0029 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0028 PF00128 Alpha amylase, catalytic domain 0.0023 PF00702 haloacid dehalogenase-like hydrolase 0.0022 PF00084 Sushi domain (SCR repeat), 0.0021 PF00002 7 transmembrane receptor (Secretin family), 0.0021 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0021 PF02793 Hormone receptor domain 0.0020 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0020 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0020 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0020 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0018 PF01055 Glycosyl hydrolases family 31 0.0018 PF09193 Cholecystokinin A receptor, N-terminal 0.0018 PF00088 Trefoil (P-type), domain 0.0018 PF00433 Protein kinase C terminal domain 0.0017 PF04679 ATP dependent DNA ligase C terminal region 0.0017 PF01068 ATP dependent DNA ligase domain 0.0015 PF00169 PH domain 0.0015 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0014 PF01370 NAD dependent epimerase/dehydratase family 0.0014 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0014 PF00578 AhpC/TSA family 0.0014 PF00188 Cysteine-rich secretory protein family 0.0013 PF01323 DSBA-like thioredoxin domain 0.0013 PF03414 Glycosyltransferase family 6 0.0012 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0012 PF02259 FAT domain 0.0012 PF08771 Rapamycin binding domain 0.0012 PF02260 FATC domain 0.0012 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0011 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0010 PF07678 A-macroglobulin complement component 0.0010 PF03489 Saposin-like type B, region 2 0.0010 PF07677 A-macroglobulin receptor 0.0010 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0010 PF01835 MG2 domain 0.0010 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0009 PF00439 Bromodomain 0.0009 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0009 PF06617 M-phase inducer phosphatase 0.0009 PF00581 Rhodanese-like domain 0.0008 PF03073 TspO/MBR family 0.0008 PF01652 Eukaryotic initiation factor 4E 0.0008 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0008 PF03770 Inositol polyphosphate kinase 0.0006 PF08983 Domain of unknown function (DUF1856), 0.0006 PF02233 NAD(P), transhydrogenase beta subunit 0.0006 PF02267 ADP-ribosyl cyclase 0.0006 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0006 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0005 PF00248 Aldo/keto reductase family 0.0004 PF00106 short chain dehydrogenase 0.0004 PF00108 Thiolase, N-terminal domain 0.0004 PF00328 Histidine acid phosphatase 0.0004 PF00675 Insulinase (Peptidase family M16), 0.0004 PF05193 Peptidase M16 inactive domain 0.0004 PF00431 CUB domain 0.0004 PF00462 Glutaredoxin 0.0004 PF02803 Thiolase, C-terminal domain 0.0004 PF00378 Enoyl-CoA hydratase/isomerase family 0.0003 PF00779 BTK motif 0.0003 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0003 PF00406 Adenylate kinase 0.0003 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0003 PF03098 Animal haem peroxidase 0.0003 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0003 PF03360 Glycosyltransferase family 43 0.0003 PF00171 Aldehyde dehydrogenase family 0.0002 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0002 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0002 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0002 PF02223 Thymidylate kinase 0.0002 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0002 PF01122 Eukaryotic cobalamin-binding protein 0.0002 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0001 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0001 PF01268 Formate--tetrahydrofolate ligase SUB607 O-C:C-C-C 0.1934 PF02159 Oestrogen receptor 0.1543 PF00001 7 transmembrane receptor (rhodopsin family), 0.1157 PF08070 DTHCT (NUC029), region 0.1157 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1157 PF00204 DNA gyrase B 0.0919 PF00576 HIUase/Transthyretin family 0.0816 PF00105 Zinc finger, C4 type (two domains), 0.0791 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0586 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0431 PF12497 Estrogen receptor beta 0.0423 PF00989 PAS fold 0.0334 PF03098 Animal haem peroxidase 0.0316 PF00027 Cyclic nucleotide-binding domain 0.0300 PF00664 ABC transporter transmembrane region 0.0289 PF00005 ABC transporter 0.0268 PF11825 Protein of unknown function (DUF3345), 0.0250 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0249 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0227 PF08674 Acetylcholinesterase tetramerisation domain 0.0216 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0194 PF00135 Carboxylesterase 0.0186 PF00266 Aminotransferase class-V 0.0152 PF01596 O-methyltransferase 0.0152 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0140 PF00186 Dihydrofolate reductase 0.0133 PF01477 PLAT/LH2 domain 0.0131 PF07884 Vitamin K epoxide reductase family 0.0121 PF00702 haloacid dehalogenase-like hydrolase 0.0117 PF00155 Aminotransferase class I and II 0.0109 PF08035 Opioids neuropeptide 0.0109 PF08384 Pro-opiomelanocortin, N-terminal region 0.0109 PF00976 Corticotropin ACTH domain 0.0083 PF00656 Caspase domain 0.0078 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0075 PF00305 Lipoxygenase 0.0075 PF00183 Hsp90 protein 0.0074 PF08983 Domain of unknown function (DUF1856), 0.0068 PF00273 Serum albumin family 0.0068 PF03765 CRAL/TRIO, N-terminus 0.0068 PF00650 CRAL/TRIO domain 0.0067 PF00643 B-box zinc finger 0.0067 PF08441 Integrin alpha 0.0057 PF00068 Phospholipase A2 0.0048 PF02394 Interleukin-1 propeptide 0.0048 PF00340 Interleukin-1 / 18 0.0048 PF00294 pfkB family carbohydrate kinase 0.0048 PF03062 MBOAT family 0.0048 PF01588 Putative tRNA binding domain 0.0038 PF00357 Integrin alpha cytoplasmic region 0.0014 PF00291 Pyridoxal-phosphate dependent enzyme 0.0013 PF07885 Ion channel 0.0011 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0011 PF00102 Protein-tyrosine phosphatase 0.0011 PF00151 Lipase 0.0011 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0008 PF07966 A1 Propeptide SUB433 C(-C)(-C)(=O) 0.1906 PF00191 Annexin 0.1663 PF02155 Glucocorticoid receptor 0.1387 PF00204 DNA gyrase B 0.1387 PF08070 DTHCT (NUC029), region 0.1387 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0936 PF01735 Lysophospholipase catalytic domain 0.0902 PF00079 Serpin (serine protease inhibitor), 0.0737 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0554 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0541 PF00105 Zinc finger, C4 type (two domains), 0.0423 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0379 PF00091 Tubulin/FtsZ family, GTPase domain 0.0379 PF03953 Tubulin C-terminal domain 0.0354 PF00168 C2 domain 0.0351 PF00102 Protein-tyrosine phosphatase 0.0210 PF00557 Metallopeptidase family M24 0.0203 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0203 PF02180 Bcl-2 homology region 4 0.0173 PF00554 Rel homology domain (RHD), 0.0172 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0169 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0158 PF00229 TNF(Tumour Necrosis Factor), family 0.0154 PF00183 Hsp90 protein 0.0129 PF00005 ABC transporter 0.0122 PF03062 MBOAT family 0.0118 PF12497 Estrogen receptor beta 0.0117 PF01477 PLAT/LH2 domain 0.0117 PF08384 Pro-opiomelanocortin, N-terminal region 0.0117 PF00976 Corticotropin ACTH domain 0.0117 PF08035 Opioids neuropeptide 0.0109 PF02173 pKID domain 0.0109 PF00273 Serum albumin family 0.0107 PF00664 ABC transporter transmembrane region 0.0103 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0094 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0093 PF07690 Major Facilitator Superfamily 0.0089 PF00170 bZIP transcription factor 0.0088 PF00656 Caspase domain 0.0083 PF02259 FAT domain 0.0083 PF03171 2OG-Fe(II), oxygenase superfamily 0.0083 PF02260 FATC domain 0.0083 PF08771 Rapamycin binding domain 0.0082 PF01347 Lipoprotein amino terminal region 0.0080 PF02159 Oestrogen receptor 0.0075 PF00341 Platelet-derived growth factor (PDGF), 0.0074 PF00576 HIUase/Transthyretin family 0.0070 PF00151 Lipase 0.0069 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0069 PF00305 Lipoxygenase 0.0064 PF01061 ABC-2 type transporter 0.0061 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0058 PF02525 Flavodoxin-like fold 0.0057 PF00531 Death domain 0.0057 PF07884 Vitamin K epoxide reductase family 0.0056 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0056 PF00271 Helicase conserved C-terminal domain 0.0056 PF09396 Thrombin light chain 0.0056 PF00405 Transferrin 0.0056 PF08742 C8 domain 0.0056 PF00176 SNF2 family N-terminal domain 0.0056 PF00094 von Willebrand factor type D domain 0.0056 PF02025 Interleukin 5 0.0054 PF00975 Thioesterase domain 0.0054 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0054 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0054 PF08659 KR domain 0.0054 PF00698 Acyl transferase domain 0.0053 PF00493 MCM2/3/5 family 0.0052 PF07648 Kazal-type serine protease inhibitor domain 0.0044 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0040 PF01596 O-methyltransferase 0.0039 PF00432 Prenyltransferase and squalene oxidase repeat 0.0037 PF00754 F5/8 type C domain 0.0037 PF01391 Collagen triple helix repeat (20 copies), 0.0035 PF00017 SH2 domain 0.0035 PF00377 Prion/Doppel alpha-helical domain 0.0035 PF00040 Fibronectin type II domain 0.0034 PF08919 F-actin binding 0.0033 PF00340 Interleukin-1 / 18 0.0033 PF02394 Interleukin-1 propeptide 0.0032 PF03098 Animal haem peroxidase 0.0030 PF00018 SH3 domain 0.0029 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0028 PF02758 PAAD/DAPIN/Pyrin domain 0.0027 PF03360 Glycosyltransferase family 43 0.0027 PF00274 Fructose-bisphosphate aldolase class-I 0.0026 PF01023 S-100/ICaBP type calcium binding domain 0.0026 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0025 PF00071 Ras family 0.0025 PF01187 Macrophage migration inhibitory factor (MIF), 0.0024 PF00489 Interleukin-6/G-CSF/MGF family 0.0024 PF12491 Apolipoprotein B100 C terminal 0.0024 PF00023 Ankyrin repeat 0.0024 PF06448 Domain of Unknown Function (DUF1081), 0.0023 PF03957 Jun-like transcription factor 0.0022 PF00291 Pyridoxal-phosphate dependent enzyme 0.0022 PF02887 Pyruvate kinase, alpha/beta domain 0.0022 PF00224 Pyruvate kinase, barrel domain 0.0020 PF00390 Malic enzyme, N-terminal domain 0.0020 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0020 PF00167 Fibroblast growth factor 0.0020 PF00266 Aminotransferase class-V 0.0020 PF03949 Malic enzyme, NAD binding domain 0.0020 PF02166 Androgen receptor 0.0020 PF00969 Class II histocompatibility antigen, beta domain 0.0019 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0019 PF00043 Glutathione S-transferase, C-terminal domain 0.0018 PF02798 Glutathione S-transferase, N-terminal domain 0.0018 PF03623 Focal adhesion targeting region 0.0018 PF02460 Patched family 0.0017 PF00354 Pentaxin family 0.0016 PF01180 Dihydroorotate dehydrogenase 0.0016 PF00342 Phosphoglucose isomerase 0.0015 PF00155 Aminotransferase class I and II 0.0015 PF02803 Thiolase, C-terminal domain 0.0015 PF00108 Thiolase, N-terminal domain 0.0014 PF00085 Thioredoxin 0.0014 PF00989 PAS fold 0.0013 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0013 PF02161 Progesterone receptor 0.0013 PF02793 Hormone receptor domain 0.0013 PF01202 Shikimate kinase 0.0013 PF00002 7 transmembrane receptor (Secretin family), 0.0013 PF02059 Interleukin-3 0.0012 PF00755 Choline/Carnitine o-acyltransferase 0.0012 PF00622 SPRY domain 0.0011 PF00027 Cyclic nucleotide-binding domain 0.0010 PF02373 JmjC domain 0.0010 PF00781 Diacylglycerol kinase catalytic domain 0.0010 PF02375 jmjN domain 0.0010 PF01388 ARID/BRIGHT DNA binding domain 0.0010 PF00860 Permease family 0.0010 PF02928 C5HC2 zinc finger 0.0010 PF00609 Diacylglycerol kinase accessory domain 0.0010 PF03034 Phosphatidyl serine synthase 0.0010 PF02824 TGS domain 0.0010 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0010 PF00643 B-box zinc finger 0.0010 PF01068 ATP dependent DNA ligase domain 0.0010 PF01753 MYND finger 0.0010 PF01731 Arylesterase 0.0010 PF08429 PLU-1-like protein 0.0010 PF00058 Low-density lipoprotein receptor repeat class B 0.0010 PF00628 PHD-finger 0.0010 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0010 PF04679 ATP dependent DNA ligase C terminal region 0.0009 PF00074 Pancreatic ribonuclease 0.0009 PF00550 Phosphopantetheine attachment site 0.0009 PF00057 Low-density lipoprotein receptor domain class A 0.0009 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0009 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0009 PF00067 Cytochrome P450 0.0009 PF00464 Serine hydroxymethyltransferase 0.0008 PF00343 Carbohydrate phosphorylase 0.0008 PF01425 Amidase 0.0008 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0008 PF01429 Methyl-CpG binding domain 0.0008 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0008 PF00654 Voltage gated chloride channel 0.0008 PF03476 MOSC N-terminal beta barrel domain 0.0008 PF03473 MOSC domain 0.0007 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0007 PF01130 CD36 family 0.0007 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0007 PF01437 Plexin repeat 0.0007 PF11404 Potassium voltage-gated channel 0.0007 PF00270 DEAD/DEAH box helicase 0.0007 PF00717 Peptidase S24-like 0.0007 PF01403 Sema domain 0.0007 PF02403 Seryl-tRNA synthetase N-terminal domain 0.0007 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0007 PF07647 SAM domain (Sterile alpha motif), 0.0007 PF02666 Phosphatidylserine decarboxylase 0.0007 PF09193 Cholecystokinin A receptor, N-terminal 0.0007 PF00246 Zinc carboxypeptidase 0.0007 PF00186 Dihydrofolate reductase 0.0007 PF03351 DOMON domain 0.0007 PF01833 IPT/TIG domain 0.0006 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.0006 PF00051 Kringle domain 0.0006 PF02898 Nitric oxide synthase, oxygenase domain 0.0005 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0005 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0005 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0005 PF01168 Alanine racemase, N-terminal domain 0.0005 PF00294 pfkB family carbohydrate kinase 0.0005 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 0.0005 PF02347 Glycine cleavage system P-protein 0.0005 PF01212 Beta-eliminating lyase 0.0004 PF00373 FERM central domain 0.0004 PF00688 TGF-beta propeptide 0.0004 PF00682 HMGL-like 0.0004 PF00020 TNFR/NGFR cysteine-rich region 0.0004 PF00028 Cadherin domain 0.0004 PF00714 Interferon gamma 0.0004 PF00019 Transforming growth factor beta like domain 0.0004 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0004 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0004 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0003 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0003 PF01462 Leucine rich repeat N-terminal domain 0.0003 PF00533 BRCA1 C Terminus (BRCT), domain 0.0003 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0003 PF08063 PADR1 (NUC008), domain 0.0003 PF00202 Aminotransferase class-III 0.0003 PF05406 WGR domain 0.0002 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0002 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF00794 PI3-kinase family, ras-binding domain 0.0002 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0002 PF01067 Calpain large subunit, domain III 0.0002 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0002 PF04961 Formiminotransferase-cyclodeaminase 0.0002 PF02971 Formiminotransferase domain 0.0002 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0002 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0002 PF00024 PAN domain 0.0002 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0002 PF00648 Calpain family cysteine protease 0.0002 PF00571 CBS domain 0.0002 PF00619 Caspase recruitment domain 0.0002 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0002 PF00787 PX domain 0.0002 PF03129 Anticodon binding domain 0.0002 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0001 PF08725 Integrin beta cytoplasmic domain 0.0001 PF00433 Protein kinase C terminal domain 0.0001 PF01365 RIH domain 0.0001 PF04756 OST3 / OST6 family 0.0001 PF03024 Folate receptor family 0.0001 PF02210 Laminin G domain 0.0001 PF00025 ADP-ribosylation factor family 0.0001 PF00227 Proteasome subunit 0.0001 PF00089 Trypsin 0.0001 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0001 PF08454 RyR and IP3R Homology associated 0.0001 PF06459 Ryanodine Receptor TM 4-6 0.0001 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0001 PF02026 RyR domain 0.0001 PF02815 MIR domain 0.0001 PF08709 Inositol 1,4,5-trisphosphate/ryanodine receptor SUB437 C(-C)(-H)(=O) 0.1897 PF00155 Aminotransferase class I and II 0.1820 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.1797 PF00266 Aminotransferase class-V 0.1329 PF00464 Serine hydroxymethyltransferase 0.1188 PF00291 Pyridoxal-phosphate dependent enzyme 0.1130 PF00202 Aminotransferase class-III 0.1078 PF01063 Aminotransferase class IV 0.1045 PF00343 Carbohydrate phosphorylase 0.0877 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0877 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0749 PF00294 pfkB family carbohydrate kinase 0.0594 PF00702 haloacid dehalogenase-like hydrolase 0.0439 PF03476 MOSC N-terminal beta barrel domain 0.0439 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0439 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0439 PF03473 MOSC domain 0.0439 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0433 PF02347 Glycine cleavage system P-protein 0.0433 PF01212 Beta-eliminating lyase 0.0433 PF01202 Shikimate kinase 0.0433 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0433 PF01168 Alanine racemase, N-terminal domain 0.0425 PF02971 Formiminotransferase domain 0.0425 PF04961 Formiminotransferase-cyclodeaminase 0.0425 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0417 PF07706 Aminotransferase ubiquitination site 0.0314 PF01596 O-methyltransferase 0.0273 PF00571 CBS domain 0.0110 PF00340 Interleukin-1 / 18 0.0110 PF02394 Interleukin-1 propeptide 0.0098 PF00342 Phosphoglucose isomerase 0.0089 PF00689 Cation transporting ATPase, C-terminus 0.0089 PF00690 Cation transporter/ATPase, N-terminus 0.0073 PF01588 Putative tRNA binding domain 0.0072 PF00576 HIUase/Transthyretin family 0.0066 PF00122 E1-E2 ATPase 0.0062 PF01916 Deoxyhypusine synthase 0.0036 PF00204 DNA gyrase B 0.0036 PF08070 DTHCT (NUC029), region 0.0036 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0032 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0025 PF00149 Calcineurin-like phosphoesterase SUB802 CC1CC(Cl)CCC1 0.1893 PF03073 TspO/MBR family 0.1711 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1711 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0188 PF00343 Carbohydrate phosphorylase 0.0172 PF08403 Amino acid permease N-terminal 0.0164 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0154 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0154 PF02254 TrkA-N domain 0.0152 PF00989 PAS fold 0.0126 PF02196 Raf-like Ras-binding domain 0.0124 PF00194 Eukaryotic-type carbonic anhydrase 0.0119 PF00027 Cyclic nucleotide-binding domain 0.0115 PF00209 Sodium:neurotransmitter symporter family 0.0107 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0105 PF00001 7 transmembrane receptor (rhodopsin family), 0.0104 PF00018 SH3 domain 0.0103 PF00186 Dihydrofolate reductase 0.0096 PF00520 Ion transport protein 0.0091 PF00017 SH2 domain 0.0084 PF06512 Sodium ion transport-associated 0.0084 PF01007 Inward rectifier potassium channel 0.0074 PF08919 F-actin binding 0.0060 PF00612 IQ calmodulin-binding motif 0.0060 PF00243 Nerve growth factor family 0.0057 PF00664 ABC transporter transmembrane region 0.0055 PF00689 Cation transporting ATPase, C-terminus 0.0055 PF00690 Cation transporter/ATPase, N-terminus 0.0054 PF00536 SAM domain (Sterile alpha motif), 0.0054 PF01404 Ephrin receptor ligand binding domain 0.0052 PF00005 ABC transporter 0.0050 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0046 PF00122 E1-E2 ATPase 0.0041 PF00324 Amino acid permease 0.0036 PF01017 STAT protein, all-alpha domain 0.0036 PF02865 STAT protein, protein interaction domain 0.0036 PF02864 STAT protein, DNA binding domain 0.0032 PF01234 NNMT/PNMT/TEMT family 0.0031 PF00702 haloacid dehalogenase-like hydrolase 0.0030 PF00069 Protein kinase domain 0.0028 PF00191 Annexin 0.0015 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0015 PF08399 VWA N-terminal 0.0015 PF02743 Cache domain 0.0014 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0010 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0009 PF03530 Calcium-activated SK potassium channel 0.0009 PF07686 Immunoglobulin V-set domain 0.0009 PF02888 Calmodulin binding domain 0.0008 PF03630 Fumble 0.0008 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0008 PF02060 Slow voltage-gated potassium channel 0.0008 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0008 PF02038 ATP1G1/PLM/MAT8 family 0.0008 PF01734 Patatin-like phospholipase 0.0004 PF03520 KCNQ voltage-gated potassium channel 0.0004 PF00146 NADH dehydrogenase 0.0003 PF00858 Amiloride-sensitive sodium channel 0.0001 PF01437 Plexin repeat 0.0001 PF00631 GGL domain 0.0001 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0001 PF02758 PAAD/DAPIN/Pyrin domain 0.0001 PF00757 Furin-like cysteine rich region 0.0001 PF02185 Hr1 repeat 0.0001 PF08912 Rho Binding 0.0001 PF08377 MAP2/Tau projection domain 0.0001 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0001 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 0.0001 PF01833 IPT/TIG domain 0.0001 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0001 PF11956 Ankyrin-G binding motif of KCNQ2-3 0.0001 PF01403 Sema domain 0.0001 PF01030 Receptor L domain 0.0001 PF00717 Peptidase S24-like SUB300 N-H 0.1891 PF00194 Eukaryotic-type carbonic anhydrase 0.0522 PF01048 Phosphorylase superfamily 0.0480 PF00186 Dihydrofolate reductase 0.0459 PF00303 Thymidylate synthase 0.0405 PF02223 Thymidylate kinase 0.0362 PF00324 Amino acid permease 0.0319 PF08403 Amino acid permease N-terminal 0.0314 PF00478 IMP dehydrogenase / GMP reductase domain 0.0300 PF00107 Zinc-binding dehydrogenase 0.0288 PF00069 Protein kinase domain 0.0286 PF08240 Alcohol dehydrogenase GroES-like domain 0.0282 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0267 PF02806 Alpha amylase, C-terminal all-beta domain 0.0260 PF01842 ACT domain 0.0256 PF02898 Nitric oxide synthase, oxygenase domain 0.0222 PF00128 Alpha amylase, catalytic domain 0.0215 PF00310 Glutamine amidotransferases class-II 0.0214 PF02254 TrkA-N domain 0.0214 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0198 PF06512 Sodium ion transport-associated 0.0193 PF02798 Glutathione S-transferase, N-terminal domain 0.0189 PF00156 Phosphoribosyl transferase domain 0.0189 PF00043 Glutathione S-transferase, C-terminal domain 0.0187 PF00175 Oxidoreductase NAD-binding domain 0.0176 PF00667 FAD binding domain 0.0176 PF00258 Flavodoxin 0.0174 PF00962 Adenosine/AMP deaminase 0.0166 PF01426 BAH domain 0.0166 PF06464 DMAP1-binding Domain 0.0166 PF02008 CXXC zinc finger domain 0.0156 PF00733 Asparagine synthase 0.0154 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0139 PF00571 CBS domain 0.0138 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0114 PF00927 Transglutaminase family, C-terminal ig like domain 0.0114 PF00868 Transglutaminase family 0.0114 PF01841 Transglutaminase-like superfamily 0.0112 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0111 PF03477 ATP cone domain 0.0111 PF00317 Ribonucleotide reductase, all-alpha domain 0.0111 PF02867 Ribonucleotide reductase, barrel domain 0.0109 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0107 PF09396 Thrombin light chain 0.0103 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0103 PF00764 Arginosuccinate synthase 0.0103 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0100 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0096 PF00958 GMP synthase C terminal domain 0.0092 PF00145 C-5 cytosine-specific DNA methylase 0.0091 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0091 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0088 PF00117 Glutamine amidotransferase class-I 0.0085 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0085 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0082 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0082 PF03199 Eukaryotic glutathione synthase 0.0082 PF01268 Formate--tetrahydrofolate ligase 0.0080 PF01063 Aminotransferase class IV 0.0069 PF00858 Amiloride-sensitive sodium channel 0.0059 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0059 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0057 PF01401 Angiotensin-converting enzyme 0.0052 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0052 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0049 PF02142 MGS-like domain 0.0049 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0046 PF01370 NAD dependent epimerase/dehydratase family 0.0039 PF00051 Kringle domain 0.0038 PF01490 Transmembrane amino acid transporter protein 0.0035 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0033 PF01467 Cytidylyltransferase 0.0030 PF02267 ADP-ribosyl cyclase 0.0023 PF02727 Copper amine oxidase, N2 domain 0.0023 PF02728 Copper amine oxidase, N3 domain 0.0023 PF01536 Adenosylmethionine decarboxylase 0.0023 PF01179 Copper amine oxidase, enzyme domain 0.0022 PF01916 Deoxyhypusine synthase 0.0021 PF00255 Glutathione peroxidase 0.0019 PF01808 AICARFT/IMPCHase bienzyme 0.0017 PF08919 F-actin binding 0.0010 PF00171 Aldehyde dehydrogenase family 0.0009 PF00018 SH3 domain 0.0009 PF00183 Hsp90 protein 0.0008 PF00375 Sodium:dicarboxylate symporter family 0.0006 PF00074 Pancreatic ribonuclease 0.0005 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0005 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0005 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0002 PF01590 GAF domain SUB594 N-C-C-C-N 0.1821 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1821 PF00204 DNA gyrase B 0.1821 PF08070 DTHCT (NUC029), region 0.1224 PF00186 Dihydrofolate reductase 0.1111 PF01048 Phosphorylase superfamily 0.1067 PF00001 7 transmembrane receptor (rhodopsin family), 0.0978 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0968 PF00069 Protein kinase domain 0.0717 PF00478 IMP dehydrogenase / GMP reductase domain 0.0530 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0426 PF08240 Alcohol dehydrogenase GroES-like domain 0.0412 PF00571 CBS domain 0.0376 PF00107 Zinc-binding dehydrogenase 0.0332 PF00962 Adenosine/AMP deaminase 0.0328 PF00017 SH2 domain 0.0321 PF02223 Thymidylate kinase 0.0318 PF00018 SH3 domain 0.0284 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0277 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0277 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0252 PF00106 short chain dehydrogenase 0.0229 PF01590 GAF domain 0.0200 PF08919 F-actin binding 0.0197 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0159 PF00005 ABC transporter 0.0150 PF00858 Amiloride-sensitive sodium channel 0.0133 PF01467 Cytidylyltransferase 0.0129 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0129 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0129 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0112 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0105 PF00171 Aldehyde dehydrogenase family 0.0096 PF00156 Phosphoribosyl transferase domain 0.0088 PF03073 TspO/MBR family 0.0077 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0077 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0061 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0028 PF01687 Riboflavin kinase 0.0023 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0023 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0023 PF01061 ABC-2 type transporter 0.0019 PF02267 ADP-ribosyl cyclase 0.0016 PF00664 ABC transporter transmembrane region 0.0006 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF02036 SCP-2 sterol transfer family 0.0005 PF01575 MaoC like domain 0.0004 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0004 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain SUB520 N=C-N-C 0.1814 PF00186 Dihydrofolate reductase 0.1198 PF01048 Phosphorylase superfamily 0.0960 PF00478 IMP dehydrogenase / GMP reductase domain 0.0854 PF00069 Protein kinase domain 0.0746 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0548 PF03073 TspO/MBR family 0.0544 PF00571 CBS domain 0.0523 PF00962 Adenosine/AMP deaminase 0.0377 PF00156 Phosphoribosyl transferase domain 0.0341 PF01590 GAF domain 0.0309 PF00106 short chain dehydrogenase 0.0302 PF08240 Alcohol dehydrogenase GroES-like domain 0.0298 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0237 PF00018 SH3 domain 0.0235 PF00107 Zinc-binding dehydrogenase 0.0221 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0221 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0212 PF08919 F-actin binding 0.0212 PF00017 SH2 domain 0.0195 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0195 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0195 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0194 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0152 PF00858 Amiloride-sensitive sodium channel 0.0137 PF00171 Aldehyde dehydrogenase family 0.0135 PF09396 Thrombin light chain 0.0133 PF01030 Receptor L domain 0.0133 PF00757 Furin-like cysteine rich region 0.0125 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0120 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0120 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0111 PF01268 Formate--tetrahydrofolate ligase 0.0099 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0099 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0079 PF01687 Riboflavin kinase 0.0071 PF00821 Phosphoenolpyruvate carboxykinase 0.0059 PF00501 AMP-binding enzyme 0.0047 PF01808 AICARFT/IMPCHase bienzyme 0.0024 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0024 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0023 PF02867 Ribonucleotide reductase, barrel domain 0.0023 PF03477 ATP cone domain 0.0023 PF00317 Ribonucleotide reductase, all-alpha domain 0.0018 PF02267 ADP-ribosyl cyclase 0.0014 PF01467 Cytidylyltransferase 0.0013 PF02223 Thymidylate kinase 0.0013 PF01122 Eukaryotic cobalamin-binding protein 0.0012 PF01404 Ephrin receptor ligand binding domain 0.0012 PF08996 DNA Polymerase alpha zinc finger 0.0012 PF00536 SAM domain (Sterile alpha motif), 0.0012 PF10397 Adenylosuccinate lyase C-terminus 0.0012 PF03104 DNA polymerase family B, exonuclease domain 0.0012 PF00136 DNA polymerase family B 0.0011 PF01119 DNA mismatch repair protein, C-terminal domain 0.0011 PF01575 MaoC like domain 0.0011 PF00498 FHA domain 0.0011 PF02036 SCP-2 sterol transfer family 0.0011 PF01652 Eukaryotic initiation factor 4E 0.0011 PF00970 Oxidoreductase FAD-binding domain 0.0011 PF12423 Kinesin protein 1B 0.0011 PF08676 MutL C terminal dimerisation domain 0.0011 PF12473 Kinesin protein 0.0009 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0004 PF03308 ArgK protein 0.0004 PF01642 Methylmalonyl-CoA mutase 0.0004 PF02310 B12 binding domain 0.0004 PF01923 Cobalamin adenosyltransferase 0.0003 PF01230 HIT domain 0.0002 PF00175 Oxidoreductase NAD-binding domain 0.0002 PF00258 Flavodoxin 0.0002 PF02607 B12 binding domain 0.0002 PF00809 Pterin binding enzyme 0.0002 PF00431 CUB domain 0.0002 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0002 PF00667 FAD binding domain 0.0001 PF02574 Homocysteine S-methyltransferase 0.0001 PF07645 Calcium-binding EGF domain SUB662 O-C-O-C-C 0.1800 PF02806 Alpha amylase, C-terminal all-beta domain 0.1434 PF00128 Alpha amylase, catalytic domain 0.1400 PF03414 Glycosyltransferase family 6 0.1173 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1173 PF08070 DTHCT (NUC029), region 0.1173 PF00204 DNA gyrase B 0.0627 PF00079 Serpin (serine protease inhibitor), 0.0610 PF00059 Lectin C-type domain 0.0586 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0575 PF00167 Fibroblast growth factor 0.0547 PF00084 Sushi domain (SCR repeat), 0.0492 PF07654 Immunoglobulin C1-set domain 0.0440 PF00143 Interferon alpha/beta domain 0.0359 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0359 PF08702 Fibrinogen alpha/beta chain family 0.0319 PF02155 Glucocorticoid receptor 0.0274 PF12160 Fibrinogen alpha C domain 0.0264 PF03727 Hexokinase 0.0264 PF00349 Hexokinase 0.0254 PF01055 Glycosyl hydrolases family 31 0.0254 PF00088 Trefoil (P-type), domain 0.0251 PF01735 Lysophospholipase catalytic domain 0.0250 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0234 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0234 PF07686 Immunoglobulin V-set domain 0.0233 PF00293 NUDIX domain 0.0226 PF02065 Melibiase 0.0219 PF00337 Galactoside-binding lectin 0.0215 PF00328 Histidine acid phosphatase 0.0203 PF02267 ADP-ribosyl cyclase 0.0192 PF00689 Cation transporting ATPase, C-terminus 0.0192 PF00690 Cation transporter/ATPase, N-terminus 0.0191 PF07645 Calcium-binding EGF domain 0.0172 PF01068 ATP dependent DNA ligase domain 0.0172 PF04679 ATP dependent DNA ligase C terminal region 0.0168 PF01370 NAD dependent epimerase/dehydratase family 0.0167 PF00089 Trypsin 0.0151 PF00122 E1-E2 ATPase 0.0150 PF00041 Fibronectin type III domain 0.0128 PF00431 CUB domain 0.0127 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0107 PF00702 haloacid dehalogenase-like hydrolase 0.0085 PF00024 PAN domain 0.0082 PF01532 Glycosyl hydrolase family 47 0.0077 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0077 PF04711 Apolipoprotein A-II (ApoA-II), 0.0077 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0077 PF00031 Cystatin domain 0.0077 PF00403 Heavy-metal-associated domain 0.0069 PF00058 Low-density lipoprotein receptor repeat class B 0.0068 PF07648 Kazal-type serine protease inhibitor domain 0.0068 PF00057 Low-density lipoprotein receptor domain class A 0.0061 PF00884 Sulfatase 0.0056 PF00191 Annexin 0.0053 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0052 PF02055 O-Glycosyl hydrolase family 30 0.0051 PF03171 2OG-Fe(II), oxygenase superfamily 0.0045 PF00703 domain 0.0045 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0045 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0045 PF08516 ADAM cysteine-rich 0.0045 PF00021 u-PAR/Ly-6 domain 0.0045 PF00200 Disintegrin 0.0045 PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), 0.0045 PF01869 BadF/BadG/BcrA/BcrD ATPase family 0.0045 PF00236 Glycoprotein hormone 0.0045 PF05735 Thrombospondin C-terminal region 0.0045 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0045 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0045 PF01562 Reprolysin family propeptide 0.0045 PF00090 Thrombospondin type 1 domain 0.0045 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0045 PF00093 von Willebrand factor type C domain 0.0045 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0045 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 0.0045 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0036 PF00183 Hsp90 protein 0.0034 PF00714 Interferon gamma 0.0032 PF03781 Formylglycine-generating sulfatase enzyme 0.0030 PF10420 Cytokine interleukin-12p40 C-terminus 0.0026 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0018 PF07884 Vitamin K epoxide reductase family 0.0017 PF08718 Glycolipid transfer protein (GLTP), 0.0002 PF00176 SNF2 family N-terminal domain SUB564 O-C-O-C 0.1800 PF02806 Alpha amylase, C-terminal all-beta domain 0.1434 PF00128 Alpha amylase, catalytic domain 0.1400 PF03414 Glycosyltransferase family 6 0.1173 PF08070 DTHCT (NUC029), region 0.1173 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1173 PF00204 DNA gyrase B 0.0627 PF00079 Serpin (serine protease inhibitor), 0.0610 PF00059 Lectin C-type domain 0.0586 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0575 PF00167 Fibroblast growth factor 0.0547 PF00084 Sushi domain (SCR repeat), 0.0492 PF07654 Immunoglobulin C1-set domain 0.0440 PF00143 Interferon alpha/beta domain 0.0359 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0359 PF08702 Fibrinogen alpha/beta chain family 0.0319 PF02155 Glucocorticoid receptor 0.0274 PF12160 Fibrinogen alpha C domain 0.0264 PF00349 Hexokinase 0.0264 PF03727 Hexokinase 0.0254 PF01055 Glycosyl hydrolases family 31 0.0254 PF00088 Trefoil (P-type), domain 0.0251 PF01735 Lysophospholipase catalytic domain 0.0250 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0234 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0234 PF07686 Immunoglobulin V-set domain 0.0233 PF00293 NUDIX domain 0.0226 PF02065 Melibiase 0.0219 PF00337 Galactoside-binding lectin 0.0215 PF00328 Histidine acid phosphatase 0.0203 PF02267 ADP-ribosyl cyclase 0.0192 PF00690 Cation transporter/ATPase, N-terminus 0.0192 PF00689 Cation transporting ATPase, C-terminus 0.0191 PF07645 Calcium-binding EGF domain 0.0172 PF04679 ATP dependent DNA ligase C terminal region 0.0172 PF01068 ATP dependent DNA ligase domain 0.0168 PF01370 NAD dependent epimerase/dehydratase family 0.0167 PF00089 Trypsin 0.0151 PF00122 E1-E2 ATPase 0.0150 PF00041 Fibronectin type III domain 0.0128 PF00431 CUB domain 0.0127 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0107 PF00702 haloacid dehalogenase-like hydrolase 0.0085 PF00024 PAN domain 0.0082 PF01532 Glycosyl hydrolase family 47 0.0077 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0077 PF00031 Cystatin domain 0.0077 PF00403 Heavy-metal-associated domain 0.0077 PF04711 Apolipoprotein A-II (ApoA-II), 0.0077 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0069 PF00058 Low-density lipoprotein receptor repeat class B 0.0068 PF00057 Low-density lipoprotein receptor domain class A 0.0068 PF07648 Kazal-type serine protease inhibitor domain 0.0061 PF00884 Sulfatase 0.0056 PF00191 Annexin 0.0053 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0052 PF02055 O-Glycosyl hydrolase family 30 0.0051 PF03171 2OG-Fe(II), oxygenase superfamily 0.0045 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 0.0045 PF01562 Reprolysin family propeptide 0.0045 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0045 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0045 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0045 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0045 PF00703 domain 0.0045 PF08516 ADAM cysteine-rich 0.0045 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0045 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0045 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0045 PF00236 Glycoprotein hormone 0.0045 PF05735 Thrombospondin C-terminal region 0.0045 PF01869 BadF/BadG/BcrA/BcrD ATPase family 0.0045 PF00090 Thrombospondin type 1 domain 0.0045 PF00021 u-PAR/Ly-6 domain 0.0045 PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), 0.0045 PF00093 von Willebrand factor type C domain 0.0045 PF00200 Disintegrin 0.0036 PF00183 Hsp90 protein 0.0034 PF00714 Interferon gamma 0.0032 PF03781 Formylglycine-generating sulfatase enzyme 0.0030 PF10420 Cytokine interleukin-12p40 C-terminus 0.0026 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0018 PF07884 Vitamin K epoxide reductase family 0.0017 PF08718 Glycolipid transfer protein (GLTP), 0.0002 PF00176 SNF2 family N-terminal domain SUB538 O=C-C-O 0.1796 PF00191 Annexin 0.1560 PF02155 Glucocorticoid receptor 0.0859 PF01735 Lysophospholipase catalytic domain 0.0833 PF00079 Serpin (serine protease inhibitor), 0.0525 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0513 PF00105 Zinc finger, C4 type (two domains), 0.0487 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0487 PF00204 DNA gyrase B 0.0487 PF08070 DTHCT (NUC029), region 0.0351 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0323 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0318 PF00168 C2 domain 0.0265 PF03953 Tubulin C-terminal domain 0.0265 PF00091 Tubulin/FtsZ family, GTPase domain 0.0260 PF00102 Protein-tyrosine phosphatase 0.0199 PF00557 Metallopeptidase family M24 0.0183 PF02180 Bcl-2 homology region 4 0.0183 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0158 PF00554 Rel homology domain (RHD), 0.0140 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0136 PF00183 Hsp90 protein 0.0136 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0134 PF00229 TNF(Tumour Necrosis Factor), family 0.0112 PF12497 Estrogen receptor beta 0.0111 PF00976 Corticotropin ACTH domain 0.0111 PF08035 Opioids neuropeptide 0.0111 PF08384 Pro-opiomelanocortin, N-terminal region 0.0106 PF03062 MBOAT family 0.0103 PF02173 pKID domain 0.0092 PF01477 PLAT/LH2 domain 0.0087 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0087 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0084 PF07690 Major Facilitator Superfamily 0.0076 PF02159 Oestrogen receptor 0.0072 PF00170 bZIP transcription factor 0.0069 PF00005 ABC transporter 0.0065 PF00656 Caspase domain 0.0064 PF00664 ABC transporter transmembrane region 0.0063 PF00151 Lipase 0.0062 PF01347 Lipoprotein amino terminal region 0.0060 PF02260 FATC domain 0.0060 PF02259 FAT domain 0.0060 PF08771 Rapamycin binding domain 0.0057 PF03171 2OG-Fe(II), oxygenase superfamily 0.0056 PF00341 Platelet-derived growth factor (PDGF), 0.0053 PF00531 Death domain 0.0051 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0048 PF07648 Kazal-type serine protease inhibitor domain 0.0045 PF02525 Flavodoxin-like fold 0.0044 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0044 PF08742 C8 domain 0.0044 PF00094 von Willebrand factor type D domain 0.0044 PF02025 Interleukin 5 0.0043 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0042 PF00305 Lipoxygenase 0.0042 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0041 PF00176 SNF2 family N-terminal domain 0.0039 PF00271 Helicase conserved C-terminal domain 0.0037 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0037 PF08659 KR domain 0.0037 PF00698 Acyl transferase domain 0.0037 PF00975 Thioesterase domain 0.0037 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0035 PF00432 Prenyltransferase and squalene oxidase repeat 0.0033 PF00493 MCM2/3/5 family 0.0030 PF01596 O-methyltransferase 0.0026 PF02758 PAAD/DAPIN/Pyrin domain 0.0024 PF01391 Collagen triple helix repeat (20 copies), 0.0023 PF00023 Ankyrin repeat 0.0021 PF00224 Pyruvate kinase, barrel domain 0.0021 PF03360 Glycosyltransferase family 43 0.0021 PF02887 Pyruvate kinase, alpha/beta domain 0.0020 PF00377 Prion/Doppel alpha-helical domain 0.0019 PF00167 Fibroblast growth factor 0.0019 PF00040 Fibronectin type II domain 0.0019 PF00489 Interleukin-6/G-CSF/MGF family 0.0019 PF02166 Androgen receptor 0.0016 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0016 PF00274 Fructose-bisphosphate aldolase class-I 0.0016 PF07884 Vitamin K epoxide reductase family 0.0015 PF00340 Interleukin-1 / 18 0.0015 PF02394 Interleukin-1 propeptide 0.0015 PF02460 Patched family 0.0015 PF00354 Pentaxin family 0.0014 PF01061 ABC-2 type transporter 0.0012 PF02161 Progesterone receptor 0.0012 PF00071 Ras family 0.0012 PF00969 Class II histocompatibility antigen, beta domain 0.0012 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0011 PF12491 Apolipoprotein B100 C terminal 0.0011 PF03623 Focal adhesion targeting region 0.0011 PF06448 Domain of Unknown Function (DUF1081), 0.0010 PF00622 SPRY domain 0.0009 PF00643 B-box zinc finger 0.0009 PF01023 S-100/ICaBP type calcium binding domain 0.0008 PF00067 Cytochrome P450 0.0007 PF00074 Pancreatic ribonuclease 0.0006 PF00342 Phosphoglucose isomerase 0.0003 PF00550 Phosphopantetheine attachment site 0.0001 PF00628 PHD-finger 0.0001 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0001 PF02928 C5HC2 zinc finger 0.0001 PF02373 JmjC domain 0.0001 PF02375 jmjN domain 0.0001 PF00860 Permease family 0.0001 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0001 PF01388 ARID/BRIGHT DNA binding domain 0.0001 PF08429 PLU-1-like protein 0.0001 PF01753 MYND finger SUB463 O-C-C=O 0.1796 PF00191 Annexin 0.1560 PF02155 Glucocorticoid receptor 0.0859 PF01735 Lysophospholipase catalytic domain 0.0833 PF00079 Serpin (serine protease inhibitor), 0.0525 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0513 PF00105 Zinc finger, C4 type (two domains), 0.0487 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0487 PF00204 DNA gyrase B 0.0487 PF08070 DTHCT (NUC029), region 0.0351 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0323 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0318 PF00168 C2 domain 0.0265 PF00091 Tubulin/FtsZ family, GTPase domain 0.0265 PF03953 Tubulin C-terminal domain 0.0260 PF00102 Protein-tyrosine phosphatase 0.0199 PF00557 Metallopeptidase family M24 0.0183 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0183 PF02180 Bcl-2 homology region 4 0.0158 PF00554 Rel homology domain (RHD), 0.0140 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0136 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0136 PF00183 Hsp90 protein 0.0134 PF00229 TNF(Tumour Necrosis Factor), family 0.0112 PF12497 Estrogen receptor beta 0.0111 PF08035 Opioids neuropeptide 0.0111 PF00976 Corticotropin ACTH domain 0.0111 PF08384 Pro-opiomelanocortin, N-terminal region 0.0106 PF03062 MBOAT family 0.0103 PF02173 pKID domain 0.0092 PF01477 PLAT/LH2 domain 0.0087 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0087 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0084 PF07690 Major Facilitator Superfamily 0.0076 PF02159 Oestrogen receptor 0.0072 PF00170 bZIP transcription factor 0.0069 PF00005 ABC transporter 0.0065 PF00656 Caspase domain 0.0064 PF00664 ABC transporter transmembrane region 0.0063 PF00151 Lipase 0.0062 PF01347 Lipoprotein amino terminal region 0.0060 PF02260 FATC domain 0.0060 PF02259 FAT domain 0.0060 PF08771 Rapamycin binding domain 0.0057 PF03171 2OG-Fe(II), oxygenase superfamily 0.0056 PF00341 Platelet-derived growth factor (PDGF), 0.0053 PF00531 Death domain 0.0051 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0048 PF07648 Kazal-type serine protease inhibitor domain 0.0045 PF02525 Flavodoxin-like fold 0.0044 PF08742 C8 domain 0.0044 PF00094 von Willebrand factor type D domain 0.0044 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0044 PF02025 Interleukin 5 0.0043 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0042 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0042 PF00305 Lipoxygenase 0.0041 PF00176 SNF2 family N-terminal domain 0.0039 PF00271 Helicase conserved C-terminal domain 0.0037 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0037 PF00975 Thioesterase domain 0.0037 PF00698 Acyl transferase domain 0.0037 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0037 PF08659 KR domain 0.0035 PF00432 Prenyltransferase and squalene oxidase repeat 0.0033 PF00493 MCM2/3/5 family 0.0030 PF01596 O-methyltransferase 0.0026 PF02758 PAAD/DAPIN/Pyrin domain 0.0024 PF01391 Collagen triple helix repeat (20 copies), 0.0023 PF00023 Ankyrin repeat 0.0021 PF02887 Pyruvate kinase, alpha/beta domain 0.0021 PF00224 Pyruvate kinase, barrel domain 0.0021 PF03360 Glycosyltransferase family 43 0.0020 PF00377 Prion/Doppel alpha-helical domain 0.0019 PF02166 Androgen receptor 0.0019 PF00040 Fibronectin type II domain 0.0019 PF00489 Interleukin-6/G-CSF/MGF family 0.0019 PF00167 Fibroblast growth factor 0.0016 PF07884 Vitamin K epoxide reductase family 0.0016 PF00274 Fructose-bisphosphate aldolase class-I 0.0016 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0015 PF02460 Patched family 0.0015 PF02394 Interleukin-1 propeptide 0.0015 PF00354 Pentaxin family 0.0015 PF00340 Interleukin-1 / 18 0.0014 PF01061 ABC-2 type transporter 0.0012 PF00969 Class II histocompatibility antigen, beta domain 0.0012 PF00071 Ras family 0.0012 PF02161 Progesterone receptor 0.0012 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0011 PF03623 Focal adhesion targeting region 0.0011 PF12491 Apolipoprotein B100 C terminal 0.0011 PF06448 Domain of Unknown Function (DUF1081), 0.0010 PF00622 SPRY domain 0.0009 PF00643 B-box zinc finger 0.0009 PF01023 S-100/ICaBP type calcium binding domain 0.0008 PF00067 Cytochrome P450 0.0007 PF00074 Pancreatic ribonuclease 0.0006 PF00342 Phosphoglucose isomerase 0.0003 PF00550 Phosphopantetheine attachment site 0.0001 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0001 PF01388 ARID/BRIGHT DNA binding domain 0.0001 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0001 PF01753 MYND finger 0.0001 PF08429 PLU-1-like protein 0.0001 PF00860 Permease family 0.0001 PF02928 C5HC2 zinc finger 0.0001 PF00628 PHD-finger 0.0001 PF02375 jmjN domain 0.0001 PF02373 JmjC domain SUB441 C(-C)(-O)(=O) 0.1789 PF03098 Animal haem peroxidase 0.1338 PF00273 Serum albumin family 0.1017 PF01401 Angiotensin-converting enzyme 0.0992 PF08070 DTHCT (NUC029), region 0.0992 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0992 PF00204 DNA gyrase B 0.0610 PF00105 Zinc finger, C4 type (two domains), 0.0605 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0501 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0486 PF03953 Tubulin C-terminal domain 0.0486 PF00091 Tubulin/FtsZ family, GTPase domain 0.0453 PF00576 HIUase/Transthyretin family 0.0444 PF00102 Protein-tyrosine phosphatase 0.0371 PF01063 Aminotransferase class IV 0.0340 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0289 PF05649 Peptidase family M13 0.0289 PF01431 Peptidase family M13 0.0263 PF00191 Annexin 0.0252 PF00079 Serpin (serine protease inhibitor), 0.0246 PF11825 Protein of unknown function (DUF3345), 0.0186 PF02798 Glutathione S-transferase, N-terminal domain 0.0182 PF00155 Aminotransferase class I and II 0.0179 PF00043 Glutathione S-transferase, C-terminal domain 0.0164 PF00202 Aminotransferase class-III 0.0126 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0126 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0112 PF02155 Glucocorticoid receptor 0.0109 PF00464 Serine hydroxymethyltransferase 0.0098 PF09396 Thrombin light chain 0.0075 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0065 PF01268 Formate--tetrahydrofolate ligase 0.0061 PF00151 Lipase 0.0057 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0055 PF00822 PMP-22/EMP/MP20/Claudin family 0.0055 PF00733 Asparagine synthase 0.0055 PF00024 PAN domain 0.0039 PF01126 Heme oxygenase 0.0037 PF02574 Homocysteine S-methyltransferase 0.0035 PF00375 Sodium:dicarboxylate symporter family 0.0032 PF01490 Transmembrane amino acid transporter protein 0.0028 PF00490 Delta-aminolevulinic acid dehydratase 0.0028 PF00764 Arginosuccinate synthase 0.0028 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0028 PF00039 Fibronectin type I domain 0.0028 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0026 PF02159 Oestrogen receptor 0.0023 PF00255 Glutathione peroxidase 0.0019 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0019 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0019 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0018 PF00458 WHEP-TRS domain 0.0017 PF01842 ACT domain 0.0015 PF00557 Metallopeptidase family M24 0.0015 PF07706 Aminotransferase ubiquitination site 0.0014 PF00303 Thymidylate synthase 0.0014 PF02806 Alpha amylase, C-terminal all-beta domain 0.0014 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0014 PF01735 Lysophospholipase catalytic domain 0.0013 PF07648 Kazal-type serine protease inhibitor domain 0.0013 PF02166 Androgen receptor 0.0010 PF04960 Glutaminase 0.0008 PF00128 Alpha amylase, catalytic domain 0.0004 PF00248 Aldo/keto reductase family 0.0004 PF03414 Glycosyltransferase family 6 0.0003 PF00854 POT family 0.0002 PF02898 Nitric oxide synthase, oxygenase domain 0.0002 PF00175 Oxidoreductase NAD-binding domain 0.0002 PF00291 Pyridoxal-phosphate dependent enzyme 0.0001 PF00667 FAD binding domain 0.0001 PF12549 Tyrosine hydroxylase N terminal 0.0001 PF00571 CBS domain 0.0001 PF00258 Flavodoxin 0.0001 PF00266 Aminotransferase class-V 0.0001 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0001 PF03171 2OG-Fe(II), oxygenase superfamily 0.0001 PF00071 Ras family SUB440 C(-C)(-N)(=O) 0.1769 PF01401 Angiotensin-converting enzyme 0.1124 PF03073 TspO/MBR family 0.1103 PF09396 Thrombin light chain 0.0934 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0745 PF00045 Hemopexin 0.0745 PF01471 Putative peptidoglycan binding domain 0.0703 PF00102 Protein-tyrosine phosphatase 0.0678 PF02798 Glutathione S-transferase, N-terminal domain 0.0660 PF00043 Glutathione S-transferase, C-terminal domain 0.0656 PF00413 Matrixin 0.0519 PF05649 Peptidase family M13 0.0519 PF01431 Peptidase family M13 0.0420 PF08983 Domain of unknown function (DUF1856), 0.0418 PF01048 Phosphorylase superfamily 0.0411 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0314 PF01590 GAF domain 0.0297 PF00303 Thymidylate synthase 0.0235 PF00255 Glutathione peroxidase 0.0189 PF00051 Kringle domain 0.0165 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0160 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0156 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0156 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0154 PF06512 Sodium ion transport-associated 0.0141 PF01268 Formate--tetrahydrofolate ligase 0.0134 PF00854 POT family 0.0119 PF00551 Formyl transferase 0.0093 PF01808 AICARFT/IMPCHase bienzyme 0.0057 PF00868 Transglutaminase family 0.0057 PF00927 Transglutaminase family, C-terminal ig like domain 0.0057 PF01841 Transglutaminase-like superfamily 0.0052 PF00026 Eukaryotic aspartyl protease 0.0051 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0051 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0051 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0048 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0040 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0040 PF01571 Aminomethyltransferase folate-binding domain 0.0039 PF07966 A1 Propeptide 0.0021 PF00089 Trypsin 0.0011 PF00586 AIR synthase related protein, N-terminal domain 0.0011 PF02769 AIR synthase related protein, C-terminal domain 0.0002 PF02142 MGS-like domain 0.0001 PF01124 MAPEG family SUB579 C-C:C-C:C 0.1767 PF00001 7 transmembrane receptor (rhodopsin family), 0.0825 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0594 PF00209 Sodium:neurotransmitter symporter family 0.0543 PF03098 Animal haem peroxidase 0.0439 PF08070 DTHCT (NUC029), region 0.0439 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0439 PF00204 DNA gyrase B 0.0397 PF06512 Sodium ion transport-associated 0.0396 PF00194 Eukaryotic-type carbonic anhydrase 0.0347 PF00520 Ion transport protein 0.0336 PF03073 TspO/MBR family 0.0206 PF00989 PAS fold 0.0172 PF09396 Thrombin light chain 0.0172 PF00102 Protein-tyrosine phosphatase 0.0170 PF00027 Cyclic nucleotide-binding domain 0.0142 PF00186 Dihydrofolate reductase 0.0132 PF03953 Tubulin C-terminal domain 0.0132 PF00091 Tubulin/FtsZ family, GTPase domain 0.0128 PF00576 HIUase/Transthyretin family 0.0127 PF01593 Flavin containing amine oxidoreductase 0.0110 PF08403 Amino acid permease N-terminal 0.0109 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0098 PF01007 Inward rectifier potassium channel 0.0072 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0067 PF00005 ABC transporter 0.0048 PF02254 TrkA-N domain 0.0048 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0043 PF02159 Oestrogen receptor 0.0042 PF07884 Vitamin K epoxide reductase family 0.0042 PF05649 Peptidase family M13 0.0042 PF01431 Peptidase family M13 0.0036 PF00664 ABC transporter transmembrane region 0.0034 PF01401 Angiotensin-converting enzyme 0.0028 PF00017 SH2 domain 0.0017 PF00069 Protein kinase domain 0.0017 PF12497 Estrogen receptor beta 0.0017 PF00822 PMP-22/EMP/MP20/Claudin family 0.0013 PF08983 Domain of unknown function (DUF1856), 0.0013 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0012 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0009 PF00018 SH3 domain 0.0007 PF00042 Globin 0.0002 PF00067 Cytochrome P450 SUB537 O=C-C-N 0.1741 PF01401 Angiotensin-converting enzyme 0.1106 PF03073 TspO/MBR family 0.1085 PF09396 Thrombin light chain 0.0919 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0733 PF00045 Hemopexin 0.0733 PF01471 Putative peptidoglycan binding domain 0.0692 PF00102 Protein-tyrosine phosphatase 0.0667 PF02798 Glutathione S-transferase, N-terminal domain 0.0649 PF00043 Glutathione S-transferase, C-terminal domain 0.0646 PF00413 Matrixin 0.0511 PF01431 Peptidase family M13 0.0511 PF05649 Peptidase family M13 0.0413 PF08983 Domain of unknown function (DUF1856), 0.0412 PF01048 Phosphorylase superfamily 0.0405 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0309 PF01590 GAF domain 0.0293 PF00303 Thymidylate synthase 0.0231 PF00255 Glutathione peroxidase 0.0186 PF00051 Kringle domain 0.0163 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0157 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0153 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0153 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0152 PF06512 Sodium ion transport-associated 0.0138 PF01268 Formate--tetrahydrofolate ligase 0.0132 PF00854 POT family 0.0117 PF00551 Formyl transferase 0.0092 PF01808 AICARFT/IMPCHase bienzyme 0.0056 PF01841 Transglutaminase-like superfamily 0.0056 PF00868 Transglutaminase family 0.0056 PF00927 Transglutaminase family, C-terminal ig like domain 0.0051 PF00026 Eukaryotic aspartyl protease 0.0050 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0050 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0050 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0047 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0040 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0040 PF01571 Aminomethyltransferase folate-binding domain 0.0039 PF07966 A1 Propeptide 0.0020 PF00089 Trypsin 0.0011 PF00586 AIR synthase related protein, N-terminal domain 0.0011 PF02769 AIR synthase related protein, C-terminal domain 0.0002 PF02142 MGS-like domain SUB431 C(-C)(-C)(=C) 0.1739 PF00001 7 transmembrane receptor (rhodopsin family), 0.1457 PF02159 Oestrogen receptor 0.1222 PF00105 Zinc finger, C4 type (two domains), 0.1217 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0968 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0749 PF08070 DTHCT (NUC029), region 0.0749 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0749 PF00204 DNA gyrase B 0.0628 PF00209 Sodium:neurotransmitter symporter family 0.0515 PF03098 Animal haem peroxidase 0.0429 PF06512 Sodium ion transport-associated 0.0394 PF02161 Progesterone receptor 0.0369 PF00191 Annexin 0.0352 PF09396 Thrombin light chain 0.0323 PF00520 Ion transport protein 0.0276 PF02155 Glucocorticoid receptor 0.0265 PF00989 PAS fold 0.0232 PF03073 TspO/MBR family 0.0210 PF00067 Cytochrome P450 0.0199 PF00027 Cyclic nucleotide-binding domain 0.0187 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0184 PF02166 Androgen receptor 0.0129 PF03953 Tubulin C-terminal domain 0.0129 PF00091 Tubulin/FtsZ family, GTPase domain 0.0102 PF01735 Lysophospholipase catalytic domain 0.0098 PF00005 ABC transporter 0.0098 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0098 PF00102 Protein-tyrosine phosphatase 0.0089 PF12497 Estrogen receptor beta 0.0069 PF00186 Dihydrofolate reductase 0.0057 PF00664 ABC transporter transmembrane region 0.0057 PF00305 Lipoxygenase 0.0007 PF07884 Vitamin K epoxide reductase family SUB476 S-C=N-C 0.1737 PF03953 Tubulin C-terminal domain 0.1737 PF00091 Tubulin/FtsZ family, GTPase domain 0.0832 PF00690 Cation transporter/ATPase, N-terminus 0.0832 PF00689 Cation transporting ATPase, C-terminus 0.0806 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0741 PF00122 E1-E2 ATPase 0.0668 PF00702 haloacid dehalogenase-like hydrolase 0.0272 PF00194 Eukaryotic-type carbonic anhydrase 0.0252 PF00018 SH3 domain 0.0230 PF00017 SH2 domain 0.0227 PF07884 Vitamin K epoxide reductase family 0.0216 PF04679 ATP dependent DNA ligase C terminal region 0.0216 PF01068 ATP dependent DNA ligase domain 0.0213 PF01770 Reduced folate carrier 0.0205 PF00102 Protein-tyrosine phosphatase 0.0205 PF08919 F-actin binding 0.0190 PF00287 Sodium / potassium ATPase beta chain 0.0152 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0146 PF00536 SAM domain (Sterile alpha motif), 0.0146 PF01404 Ephrin receptor ligand binding domain 0.0130 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0128 PF00146 NADH dehydrogenase 0.0121 PF00854 POT family 0.0117 PF00478 IMP dehydrogenase / GMP reductase domain 0.0101 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0101 PF01017 STAT protein, all-alpha domain 0.0101 PF02865 STAT protein, protein interaction domain 0.0101 PF02864 STAT protein, DNA binding domain 0.0099 PF00962 Adenosine/AMP deaminase 0.0081 PF00183 Hsp90 protein 0.0081 PF00656 Caspase domain 0.0080 PF02059 Interleukin-3 0.0080 PF00377 Prion/Doppel alpha-helical domain 0.0077 PF02394 Interleukin-1 propeptide 0.0077 PF00340 Interleukin-1 / 18 0.0076 PF12497 Estrogen receptor beta 0.0074 PF00156 Phosphoribosyl transferase domain 0.0074 PF10397 Adenylosuccinate lyase C-terminus 0.0067 PF02214 K+ channel tetramerisation domain 0.0065 PF00230 Major intrinsic protein 0.0063 PF00958 GMP synthase C terminal domain 0.0062 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0062 PF02254 TrkA-N domain 0.0059 PF00069 Protein kinase domain 0.0057 PF01023 S-100/ICaBP type calcium binding domain 0.0051 PF03098 Animal haem peroxidase 0.0050 PF00020 TNFR/NGFR cysteine-rich region 0.0048 PF00667 FAD binding domain 0.0048 PF00258 Flavodoxin 0.0047 PF00175 Oxidoreductase NAD-binding domain 0.0046 PF00206 Lyase 0.0046 PF02898 Nitric oxide synthase, oxygenase domain 0.0045 PF00619 Caspase recruitment domain 0.0045 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0045 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0043 PF02525 Flavodoxin-like fold 0.0043 PF00341 Platelet-derived growth factor (PDGF), 0.0039 PF00273 Serum albumin family 0.0038 PF00305 Lipoxygenase 0.0037 PF00041 Fibronectin type III domain 0.0037 PF09396 Thrombin light chain 0.0036 PF00040 Fibronectin type II domain 0.0036 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0036 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0036 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0032 PF00531 Death domain 0.0032 PF00631 GGL domain 0.0032 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0030 PF01122 Eukaryotic cobalamin-binding protein 0.0030 PF03073 TspO/MBR family 0.0029 PF02155 Glucocorticoid receptor 0.0028 PF03530 Calcium-activated SK potassium channel 0.0028 PF02888 Calmodulin binding domain 0.0027 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0026 PF00520 Ion transport protein 0.0024 PF00709 Adenylosuccinate synthetase 0.0023 PF00117 Glutamine amidotransferase class-I 0.0022 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0022 PF00571 CBS domain 0.0022 PF00245 Alkaline phosphatase 0.0021 PF01923 Cobalamin adenosyltransferase 0.0021 PF03308 ArgK protein 0.0021 PF01642 Methylmalonyl-CoA mutase 0.0020 PF00001 7 transmembrane receptor (rhodopsin family), 0.0019 PF02310 B12 binding domain 0.0019 PF01687 Riboflavin kinase 0.0017 PF00310 Glutamine amidotransferases class-II 0.0016 PF01477 PLAT/LH2 domain 0.0016 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0016 PF00792 Phosphoinositide 3-kinase C2 0.0016 PF00794 PI3-kinase family, ras-binding domain 0.0014 PF01835 MG2 domain 0.0014 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0014 PF07677 A-macroglobulin receptor 0.0014 PF07678 A-macroglobulin complement component 0.0013 PF08403 Amino acid permease N-terminal 0.0013 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0012 PF00060 Ligand-gated ion channel 0.0011 PF01425 Amidase 0.0011 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0010 PF01437 Plexin repeat 0.0010 PF00191 Annexin 0.0010 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0010 PF00489 Interleukin-6/G-CSF/MGF family 0.0010 PF01403 Sema domain 0.0010 PF02441 Flavoprotein 0.0010 PF01833 IPT/TIG domain 0.0009 PF07885 Ion channel 0.0009 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0009 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0009 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0009 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0009 PF08377 MAP2/Tau projection domain 0.0009 PF00654 Voltage gated chloride channel 0.0008 PF00459 Inositol monophosphatase family 0.0008 PF00970 Oxidoreductase FAD-binding domain 0.0008 PF00576 HIUase/Transthyretin family 0.0007 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0007 PF00405 Transferrin 0.0007 PF01731 Arylesterase 0.0007 PF00625 Guanylate kinase 0.0006 PF00533 BRCA1 C Terminus (BRCT), domain 0.0006 PF00779 BTK motif 0.0006 PF01007 Inward rectifier potassium channel 0.0006 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0006 PF08063 PADR1 (NUC008), domain 0.0006 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0006 PF05406 WGR domain 0.0006 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0006 PF02196 Raf-like Ras-binding domain 0.0006 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0006 PF02607 B12 binding domain 0.0006 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0006 PF00809 Pterin binding enzyme 0.0006 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0006 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0006 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0005 PF00134 Cyclin, N-terminal domain 0.0005 PF02828 L27 domain 0.0005 PF03453 MoeA N-terminal region (domain I and II), 0.0005 PF03454 MoeA C-terminal region (domain IV), 0.0005 PF00514 Armadillo/beta-catenin-like repeat 0.0005 PF01094 Receptor family ligand binding region 0.0005 PF00994 Probable molybdopterin binding domain 0.0005 PF02984 Cyclin, C-terminal domain 0.0005 PF12126 Protein of unknown function (DUF3583), 0.0005 PF00431 CUB domain 0.0005 PF07970 Endoplasmic reticulum vesicle transporter 0.0005 PF01180 Dihydroorotate dehydrogenase 0.0004 PF05193 Peptidase M16 inactive domain 0.0004 PF08399 VWA N-terminal 0.0004 PF00089 Trypsin 0.0004 PF02743 Cache domain 0.0004 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0004 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0004 PF00675 Insulinase (Peptidase family M16), 0.0003 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0003 PF00303 Thymidylate synthase 0.0003 PF00406 Adenylate kinase 0.0003 PF00989 PAS fold 0.0003 PF01369 Sec7 domain 0.0002 PF07653 Variant SH3 domain 0.0002 PF08763 Voltage gated calcium channel IQ domain 0.0002 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0002 PF00042 Globin 0.0002 PF11857 Domain of unknown function (DUF3377), 0.0002 PF00462 Glutaredoxin 0.0001 PF00581 Rhodanese-like domain 0.0001 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0001 PF00027 Cyclic nucleotide-binding domain 0.0001 PF02189 Immunoreceptor tyrosine-based activation motif 0.0001 PF06464 DMAP1-binding Domain 0.0001 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0001 PF03957 Jun-like transcription factor 0.0001 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.0001 PF06617 M-phase inducer phosphatase 0.0001 PF01426 BAH domain 0.0001 PF02008 CXXC zinc finger domain 0.0001 PF01733 Nucleoside transporter 0.0001 PF00557 Metallopeptidase family M24 0.0001 PF02038 ATP1G1/PLM/MAT8 family SUB179 >= 1 any ring size 6 0.1729 PF00001 7 transmembrane receptor (rhodopsin family), 0.0736 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0713 PF03098 Animal haem peroxidase 0.0644 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0642 PF00105 Zinc finger, C4 type (two domains), 0.0608 PF02159 Oestrogen receptor 0.0445 PF00209 Sodium:neurotransmitter symporter family 0.0347 PF06512 Sodium ion transport-associated 0.0233 PF03073 TspO/MBR family 0.0195 PF09396 Thrombin light chain 0.0164 PF00005 ABC transporter 0.0161 PF00191 Annexin 0.0159 PF00989 PAS fold 0.0135 PF00067 Cytochrome P450 0.0134 PF00520 Ion transport protein 0.0133 PF00664 ABC transporter transmembrane region 0.0128 PF00027 Cyclic nucleotide-binding domain 0.0094 PF02155 Glucocorticoid receptor 0.0076 PF02161 Progesterone receptor 0.0076 PF01593 Flavin containing amine oxidoreductase 0.0055 PF00186 Dihydrofolate reductase 0.0051 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0039 PF01007 Inward rectifier potassium channel 0.0023 PF01735 Lysophospholipase catalytic domain 0.0020 PF11825 Protein of unknown function (DUF3345), 0.0017 PF00017 SH2 domain 0.0014 PF12497 Estrogen receptor beta SUB751 Nc1cc(Cl)ccc1 0.1713 PF00194 Eukaryotic-type carbonic anhydrase 0.0832 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0832 PF02254 TrkA-N domain 0.0703 PF08403 Amino acid permease N-terminal 0.0659 PF00001 7 transmembrane receptor (rhodopsin family), 0.0296 PF00324 Amino acid permease 0.0218 PF00690 Cation transporter/ATPase, N-terminus 0.0218 PF00689 Cation transporting ATPase, C-terminus 0.0192 PF00122 E1-E2 ATPase 0.0171 PF00520 Ion transport protein 0.0169 PF00702 haloacid dehalogenase-like hydrolase 0.0149 PF02038 ATP1G1/PLM/MAT8 family 0.0077 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0051 PF00043 Glutathione S-transferase, C-terminal domain 0.0048 PF02798 Glutathione S-transferase, N-terminal domain 0.0044 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0037 PF00822 PMP-22/EMP/MP20/Claudin family 0.0030 PF00357 Integrin alpha cytoplasmic region 0.0020 PF08441 Integrin alpha 0.0018 PF01734 Patatin-like phospholipase 0.0016 PF00757 Furin-like cysteine rich region 0.0016 PF01030 Receptor L domain 0.0014 PF09396 Thrombin light chain 0.0011 PF00102 Protein-tyrosine phosphatase 0.0007 PF01007 Inward rectifier potassium channel 0.0006 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0006 PF01582 TIR domain 0.0006 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0006 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0006 PF00042 Globin 0.0002 PF00305 Lipoxygenase SUB814 NC1CC(Cl)CCC1 0.1713 PF00194 Eukaryotic-type carbonic anhydrase 0.0832 PF02254 TrkA-N domain 0.0832 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0703 PF08403 Amino acid permease N-terminal 0.0659 PF00001 7 transmembrane receptor (rhodopsin family), 0.0296 PF00324 Amino acid permease 0.0218 PF00689 Cation transporting ATPase, C-terminus 0.0218 PF00690 Cation transporter/ATPase, N-terminus 0.0192 PF00122 E1-E2 ATPase 0.0171 PF00520 Ion transport protein 0.0169 PF00702 haloacid dehalogenase-like hydrolase 0.0149 PF02038 ATP1G1/PLM/MAT8 family 0.0077 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0051 PF00043 Glutathione S-transferase, C-terminal domain 0.0048 PF02798 Glutathione S-transferase, N-terminal domain 0.0044 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0037 PF00822 PMP-22/EMP/MP20/Claudin family 0.0030 PF00357 Integrin alpha cytoplasmic region 0.0020 PF08441 Integrin alpha 0.0018 PF01734 Patatin-like phospholipase 0.0016 PF01030 Receptor L domain 0.0016 PF00757 Furin-like cysteine rich region 0.0014 PF09396 Thrombin light chain 0.0011 PF00102 Protein-tyrosine phosphatase 0.0007 PF01007 Inward rectifier potassium channel 0.0006 PF01582 TIR domain 0.0006 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0006 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0006 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0006 PF00042 Globin 0.0002 PF00305 Lipoxygenase SUB509 S=C-N-C 0.1710 PF00091 Tubulin/FtsZ family, GTPase domain 0.1710 PF03953 Tubulin C-terminal domain 0.0247 PF07884 Vitamin K epoxide reductase family 0.0228 PF00018 SH3 domain 0.0201 PF00017 SH2 domain 0.0198 PF04679 ATP dependent DNA ligase C terminal region 0.0198 PF01068 ATP dependent DNA ligase domain 0.0196 PF01770 Reduced folate carrier 0.0190 PF08919 F-actin binding 0.0172 PF00102 Protein-tyrosine phosphatase 0.0162 PF00194 Eukaryotic-type carbonic anhydrase 0.0139 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0135 PF01404 Ephrin receptor ligand binding domain 0.0135 PF00536 SAM domain (Sterile alpha motif), 0.0108 PF00854 POT family 0.0093 PF01017 STAT protein, all-alpha domain 0.0093 PF02864 STAT protein, DNA binding domain 0.0093 PF02865 STAT protein, protein interaction domain 0.0093 PF00478 IMP dehydrogenase / GMP reductase domain 0.0088 PF00183 Hsp90 protein 0.0088 PF00656 Caspase domain 0.0087 PF00377 Prion/Doppel alpha-helical domain 0.0087 PF02059 Interleukin-3 0.0086 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0084 PF02394 Interleukin-1 propeptide 0.0084 PF00340 Interleukin-1 / 18 0.0076 PF00962 Adenosine/AMP deaminase 0.0062 PF01023 S-100/ICaBP type calcium binding domain 0.0059 PF00156 Phosphoribosyl transferase domain 0.0059 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0056 PF00069 Protein kinase domain 0.0056 PF10397 Adenylosuccinate lyase C-terminus 0.0055 PF00020 TNFR/NGFR cysteine-rich region 0.0055 PF03098 Animal haem peroxidase 0.0049 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0049 PF00958 GMP synthase C terminal domain 0.0049 PF00619 Caspase recruitment domain 0.0046 PF00341 Platelet-derived growth factor (PDGF), 0.0046 PF02525 Flavodoxin-like fold 0.0042 PF00305 Lipoxygenase 0.0040 PF09396 Thrombin light chain 0.0039 PF00040 Fibronectin type II domain 0.0037 PF00041 Fibronectin type III domain 0.0037 PF12497 Estrogen receptor beta 0.0035 PF00531 Death domain 0.0034 PF00206 Lyase 0.0032 PF02155 Glucocorticoid receptor 0.0029 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0022 PF00001 7 transmembrane receptor (rhodopsin family), 0.0019 PF00273 Serum albumin family 0.0018 PF00117 Glutamine amidotransferase class-I 0.0018 PF00709 Adenylosuccinate synthetase 0.0017 PF01477 PLAT/LH2 domain 0.0015 PF00245 Alkaline phosphatase 0.0015 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0014 PF00310 Glutamine amidotransferases class-II 0.0014 PF00230 Major intrinsic protein 0.0014 PF00571 CBS domain 0.0012 PF01425 Amidase 0.0011 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0011 PF02254 TrkA-N domain 0.0010 PF00689 Cation transporting ATPase, C-terminus 0.0010 PF00287 Sodium / potassium ATPase beta chain 0.0010 PF00690 Cation transporter/ATPase, N-terminus 0.0009 PF07677 A-macroglobulin receptor 0.0009 PF07678 A-macroglobulin complement component 0.0009 PF01835 MG2 domain 0.0009 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0008 PF01731 Arylesterase 0.0006 PF00122 E1-E2 ATPase 0.0002 PF08403 Amino acid permease N-terminal 0.0002 PF11857 Domain of unknown function (DUF3377), 0.0001 PF00557 Metallopeptidase family M24 0.0001 PF05193 Peptidase M16 inactive domain 0.0001 PF02038 ATP1G1/PLM/MAT8 family 0.0001 PF00675 Insulinase (Peptidase family M16), SUB602 N-C:C:C-N 0.1704 PF00186 Dihydrofolate reductase 0.0906 PF00069 Protein kinase domain 0.0752 PF00478 IMP dehydrogenase / GMP reductase domain 0.0656 PF08240 Alcohol dehydrogenase GroES-like domain 0.0590 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0584 PF01048 Phosphorylase superfamily 0.0579 PF00107 Zinc-binding dehydrogenase 0.0536 PF00106 short chain dehydrogenase 0.0495 PF00571 CBS domain 0.0380 PF00962 Adenosine/AMP deaminase 0.0356 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0356 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0355 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0355 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0355 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0298 PF00171 Aldehyde dehydrogenase family 0.0242 PF00018 SH3 domain 0.0235 PF00248 Aldo/keto reductase family 0.0225 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0225 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0205 PF02223 Thymidylate kinase 0.0201 PF00156 Phosphoribosyl transferase domain 0.0174 PF00017 SH2 domain 0.0170 PF00501 AMP-binding enzyme 0.0153 PF08919 F-actin binding 0.0129 PF01467 Cytidylyltransferase 0.0103 PF00225 Kinesin motor domain 0.0100 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0100 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0099 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0089 PF01230 HIT domain 0.0086 PF03104 DNA polymerase family B, exonuclease domain 0.0086 PF00970 Oxidoreductase FAD-binding domain 0.0086 PF08996 DNA Polymerase alpha zinc finger 0.0086 PF01575 MaoC like domain 0.0086 PF00498 FHA domain 0.0086 PF12423 Kinesin protein 1B 0.0086 PF12473 Kinesin protein 0.0086 PF02036 SCP-2 sterol transfer family 0.0086 PF01119 DNA mismatch repair protein, C-terminal domain 0.0086 PF08676 MutL C terminal dimerisation domain 0.0086 PF00136 DNA polymerase family B 0.0085 PF03949 Malic enzyme, NAD binding domain 0.0085 PF00390 Malic enzyme, N-terminal domain 0.0078 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0078 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0078 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0078 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0071 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0071 PF02233 NAD(P), transhydrogenase beta subunit 0.0071 PF00931 NB-ARC domain 0.0071 PF00400 WD domain, G-beta repeat 0.0071 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0058 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0056 PF02867 Ribonucleotide reductase, barrel domain 0.0056 PF00317 Ribonucleotide reductase, all-alpha domain 0.0056 PF03477 ATP cone domain 0.0055 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0055 PF03770 Inositol polyphosphate kinase 0.0051 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0045 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0045 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0026 PF00757 Furin-like cysteine rich region 0.0026 PF01030 Receptor L domain 0.0025 PF01268 Formate--tetrahydrofolate ligase 0.0024 PF00858 Amiloride-sensitive sodium channel 0.0016 PF08515 Transforming growth factor beta type I GS-motif 0.0016 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0016 PF01064 Activin types I and II receptor domain 0.0016 PF00378 Enoyl-CoA hydratase/isomerase family 0.0016 PF00676 Dehydrogenase E1 component 0.0010 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0007 PF00005 ABC transporter 0.0003 PF01126 Heme oxygenase 0.0002 PF02525 Flavodoxin-like fold SUB675 N-C-N-C:C 0.1698 PF00186 Dihydrofolate reductase 0.1122 PF01048 Phosphorylase superfamily 0.0898 PF00478 IMP dehydrogenase / GMP reductase domain 0.0799 PF00069 Protein kinase domain 0.0698 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0513 PF03073 TspO/MBR family 0.0509 PF00571 CBS domain 0.0489 PF00962 Adenosine/AMP deaminase 0.0353 PF00156 Phosphoribosyl transferase domain 0.0319 PF01590 GAF domain 0.0288 PF00106 short chain dehydrogenase 0.0282 PF08240 Alcohol dehydrogenase GroES-like domain 0.0279 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0222 PF00018 SH3 domain 0.0220 PF00107 Zinc-binding dehydrogenase 0.0206 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0206 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0199 PF00017 SH2 domain 0.0198 PF08919 F-actin binding 0.0182 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0182 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0182 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0181 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0142 PF00858 Amiloride-sensitive sodium channel 0.0128 PF00171 Aldehyde dehydrogenase family 0.0127 PF09396 Thrombin light chain 0.0124 PF01030 Receptor L domain 0.0124 PF00757 Furin-like cysteine rich region 0.0117 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0112 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0112 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0103 PF01268 Formate--tetrahydrofolate ligase 0.0093 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0093 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0074 PF01687 Riboflavin kinase 0.0066 PF00821 Phosphoenolpyruvate carboxykinase 0.0055 PF00501 AMP-binding enzyme 0.0044 PF01808 AICARFT/IMPCHase bienzyme 0.0023 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0023 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0021 PF02867 Ribonucleotide reductase, barrel domain 0.0021 PF03477 ATP cone domain 0.0021 PF00317 Ribonucleotide reductase, all-alpha domain 0.0017 PF02267 ADP-ribosyl cyclase 0.0013 PF01467 Cytidylyltransferase 0.0012 PF02223 Thymidylate kinase 0.0011 PF00536 SAM domain (Sterile alpha motif), 0.0011 PF00498 FHA domain 0.0011 PF08996 DNA Polymerase alpha zinc finger 0.0011 PF03104 DNA polymerase family B, exonuclease domain 0.0011 PF00136 DNA polymerase family B 0.0011 PF12423 Kinesin protein 1B 0.0011 PF10397 Adenylosuccinate lyase C-terminus 0.0011 PF12473 Kinesin protein 0.0011 PF01119 DNA mismatch repair protein, C-terminal domain 0.0011 PF08676 MutL C terminal dimerisation domain 0.0011 PF01404 Ephrin receptor ligand binding domain 0.0010 PF01575 MaoC like domain 0.0010 PF00970 Oxidoreductase FAD-binding domain 0.0010 PF02036 SCP-2 sterol transfer family 0.0010 PF01652 Eukaryotic initiation factor 4E 0.0008 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0007 PF01122 Eukaryotic cobalamin-binding protein 0.0003 PF01230 HIT domain SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 0.1696 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1696 PF00204 DNA gyrase B 0.1696 PF08070 DTHCT (NUC029), region 0.1140 PF00186 Dihydrofolate reductase 0.1034 PF01048 Phosphorylase superfamily 0.0994 PF00001 7 transmembrane receptor (rhodopsin family), 0.0910 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0902 PF00069 Protein kinase domain 0.0668 PF00478 IMP dehydrogenase / GMP reductase domain 0.0493 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0396 PF08240 Alcohol dehydrogenase GroES-like domain 0.0384 PF00571 CBS domain 0.0350 PF00107 Zinc-binding dehydrogenase 0.0309 PF00962 Adenosine/AMP deaminase 0.0306 PF00017 SH2 domain 0.0299 PF02223 Thymidylate kinase 0.0296 PF00018 SH3 domain 0.0265 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0258 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0258 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0235 PF00106 short chain dehydrogenase 0.0213 PF01590 GAF domain 0.0186 PF08919 F-actin binding 0.0183 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0148 PF00005 ABC transporter 0.0139 PF00858 Amiloride-sensitive sodium channel 0.0124 PF01467 Cytidylyltransferase 0.0120 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0120 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0120 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0104 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0098 PF00171 Aldehyde dehydrogenase family 0.0089 PF00156 Phosphoribosyl transferase domain 0.0082 PF03073 TspO/MBR family 0.0071 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0071 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0057 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0026 PF01687 Riboflavin kinase 0.0022 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0022 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0021 PF01061 ABC-2 type transporter 0.0018 PF02267 ADP-ribosyl cyclase 0.0015 PF00664 ABC transporter transmembrane region 0.0006 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0004 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0004 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0004 PF01575 MaoC like domain 0.0004 PF02036 SCP-2 sterol transfer family SUB443 C(-C)(=N) 0.1687 PF03073 TspO/MBR family 0.1243 PF00069 Protein kinase domain 0.1151 PF00186 Dihydrofolate reductase 0.1065 PF01048 Phosphorylase superfamily 0.0793 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0596 PF00478 IMP dehydrogenase / GMP reductase domain 0.0517 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0435 PF03953 Tubulin C-terminal domain 0.0435 PF00091 Tubulin/FtsZ family, GTPase domain 0.0422 PF00571 CBS domain 0.0375 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0375 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0320 PF00962 Adenosine/AMP deaminase 0.0284 PF01126 Heme oxygenase 0.0256 PF01590 GAF domain 0.0163 PF00156 Phosphoribosyl transferase domain 0.0163 PF08240 Alcohol dehydrogenase GroES-like domain 0.0159 PF00017 SH2 domain 0.0147 PF00042 Globin 0.0133 PF00107 Zinc-binding dehydrogenase 0.0122 PF00018 SH3 domain 0.0114 PF00858 Amiloride-sensitive sodium channel 0.0106 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0097 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0073 PF00343 Carbohydrate phosphorylase 0.0071 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0071 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0064 PF02267 ADP-ribosyl cyclase 0.0051 PF00106 short chain dehydrogenase 0.0038 PF08919 F-actin binding 0.0022 PF00005 ABC transporter 0.0010 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0004 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0004 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0004 PF00441 Acyl-CoA dehydrogenase, C-terminal domain SUB3 >= 16 H 0.1687 PF02159 Oestrogen receptor 0.1246 PF00105 Zinc finger, C4 type (two domains), 0.1227 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0730 PF00001 7 transmembrane receptor (rhodopsin family), 0.0713 PF00204 DNA gyrase B 0.0713 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0713 PF08070 DTHCT (NUC029), region 0.0697 PF00191 Annexin 0.0656 PF02155 Glucocorticoid receptor 0.0498 PF02161 Progesterone receptor 0.0356 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0348 PF01735 Lysophospholipase catalytic domain 0.0320 PF00079 Serpin (serine protease inhibitor), 0.0291 PF02166 Androgen receptor 0.0274 PF00091 Tubulin/FtsZ family, GTPase domain 0.0274 PF03953 Tubulin C-terminal domain 0.0240 PF00976 Corticotropin ACTH domain 0.0240 PF08384 Pro-opiomelanocortin, N-terminal region 0.0240 PF08035 Opioids neuropeptide 0.0233 PF00005 ABC transporter 0.0229 PF12497 Estrogen receptor beta 0.0209 PF00664 ABC transporter transmembrane region 0.0208 PF00989 PAS fold 0.0171 PF00027 Cyclic nucleotide-binding domain 0.0151 PF00168 C2 domain 0.0120 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0093 PF00273 Serum albumin family 0.0091 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0084 PF01401 Angiotensin-converting enzyme 0.0082 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0079 PF01477 PLAT/LH2 domain 0.0076 PF03414 Glycosyltransferase family 6 0.0068 PF00822 PMP-22/EMP/MP20/Claudin family 0.0068 PF00067 Cytochrome P450 0.0052 PF11825 Protein of unknown function (DUF3345), 0.0051 PF02806 Alpha amylase, C-terminal all-beta domain 0.0045 PF09396 Thrombin light chain 0.0043 PF03098 Animal haem peroxidase 0.0041 PF07966 A1 Propeptide 0.0040 PF00305 Lipoxygenase 0.0033 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0032 PF00026 Eukaryotic aspartyl protease 0.0030 PF07648 Kazal-type serine protease inhibitor domain 0.0026 PF00186 Dihydrofolate reductase 0.0025 PF07884 Vitamin K epoxide reductase family 0.0024 PF01061 ABC-2 type transporter 0.0020 PF02394 Interleukin-1 propeptide 0.0020 PF00340 Interleukin-1 / 18 0.0020 PF00151 Lipase 0.0018 PF00183 Hsp90 protein 0.0018 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0017 PF00643 B-box zinc finger 0.0016 PF00042 Globin 0.0014 PF00229 TNF(Tumour Necrosis Factor), family 0.0013 PF08441 Integrin alpha 0.0012 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0012 PF00051 Kringle domain 0.0012 PF00059 Lectin C-type domain 0.0011 PF08763 Voltage gated calcium channel IQ domain 0.0007 PF04622 ERG2 and Sigma1 receptor like protein 0.0006 PF08771 Rapamycin binding domain 0.0006 PF03765 CRAL/TRIO, N-terminus 0.0006 PF02259 FAT domain 0.0006 PF02260 FATC domain 0.0006 PF00554 Rel homology domain (RHD), 0.0006 PF00650 CRAL/TRIO domain 0.0005 PF00357 Integrin alpha cytoplasmic region 0.0005 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0005 PF06327 Domain of Unknown Function (DUF1053), 0.0005 PF00128 Alpha amylase, catalytic domain 0.0003 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0003 PF03062 MBOAT family 0.0003 PF07885 Ion channel 0.0002 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0002 PF00341 Platelet-derived growth factor (PDGF), 0.0002 PF02180 Bcl-2 homology region 4 0.0002 PF00212 Atrial natriuretic peptide SUB695 O=C-C-C-C-C=O 0.1678 PF02798 Glutathione S-transferase, N-terminal domain 0.1641 PF00043 Glutathione S-transferase, C-terminal domain 0.0994 PF00255 Glutathione peroxidase 0.0800 PF01431 Peptidase family M13 0.0800 PF05649 Peptidase family M13 0.0697 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0561 PF01124 MAPEG family 0.0521 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0495 PF00091 Tubulin/FtsZ family, GTPase domain 0.0495 PF03953 Tubulin C-terminal domain 0.0482 PF01401 Angiotensin-converting enzyme 0.0455 PF09396 Thrombin light chain 0.0440 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0440 PF03199 Eukaryotic glutathione synthase 0.0338 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0334 PF01323 DSBA-like thioredoxin domain 0.0302 PF00656 Caspase domain 0.0296 PF08983 Domain of unknown function (DUF1856), 0.0280 PF00303 Thymidylate synthase 0.0260 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0245 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0242 PF00462 Glutaredoxin 0.0229 PF07722 Peptidase C26 0.0200 PF01406 tRNA synthetases class I (C), catalytic domain 0.0193 PF05995 Cysteine dioxygenase type I 0.0191 PF00756 Putative esterase 0.0191 PF01019 Gamma-glutamyltranspeptidase 0.0171 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0171 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0165 PF00619 Caspase recruitment domain 0.0159 PF03074 Glutamate-cysteine ligase 0.0111 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0109 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0109 PF00439 Bromodomain 0.0097 PF06617 M-phase inducer phosphatase 0.0097 PF00581 Rhodanese-like domain 0.0088 PF03002 Somatostatin/Cortistatin family 0.0087 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0084 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0075 PF00085 Thioredoxin 0.0073 PF00778 DIX domain 0.0073 PF00806 Pumilio-family RNA binding repeat 0.0073 PF08833 Axin beta-catenin binding domain 0.0071 PF00822 PMP-22/EMP/MP20/Claudin family 0.0065 PF00265 Thymidine kinase 0.0062 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0062 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0053 PF00342 Phosphoglucose isomerase 0.0052 PF00931 NB-ARC domain 0.0052 PF00400 WD domain, G-beta repeat 0.0039 PF02793 Hormone receptor domain 0.0039 PF00002 7 transmembrane receptor (Secretin family), 0.0029 PF01268 Formate--tetrahydrofolate ligase 0.0017 PF02769 AIR synthase related protein, C-terminal domain 0.0017 PF00586 AIR synthase related protein, N-terminal domain 0.0016 PF10420 Cytokine interleukin-12p40 C-terminus 0.0013 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0013 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0010 PF00045 Hemopexin 0.0010 PF01471 Putative peptidoglycan binding domain 0.0009 PF02803 Thiolase, C-terminal domain 0.0009 PF00108 Thiolase, N-terminal domain 0.0002 PF00551 Formyl transferase SUB665 C-C=C-C=C 0.1673 PF00001 7 transmembrane receptor (rhodopsin family), 0.0798 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0557 PF00209 Sodium:neurotransmitter symporter family 0.0490 PF03098 Animal haem peroxidase 0.0438 PF08070 DTHCT (NUC029), region 0.0438 PF00204 DNA gyrase B 0.0438 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0377 PF06512 Sodium ion transport-associated 0.0338 PF00194 Eukaryotic-type carbonic anhydrase 0.0317 PF03073 TspO/MBR family 0.0299 PF00520 Ion transport protein 0.0200 PF00989 PAS fold 0.0176 PF00102 Protein-tyrosine phosphatase 0.0164 PF09396 Thrombin light chain 0.0163 PF00027 Cyclic nucleotide-binding domain 0.0162 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0157 PF00186 Dihydrofolate reductase 0.0137 PF00005 ABC transporter 0.0115 PF01593 Flavin containing amine oxidoreductase 0.0110 PF00576 HIUase/Transthyretin family 0.0096 PF00664 ABC transporter transmembrane region 0.0093 PF00069 Protein kinase domain 0.0076 PF01007 Inward rectifier potassium channel 0.0076 PF08403 Amino acid permease N-terminal 0.0054 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0044 PF00017 SH2 domain 0.0039 PF01431 Peptidase family M13 0.0039 PF05649 Peptidase family M13 0.0035 PF07884 Vitamin K epoxide reductase family 0.0028 PF03953 Tubulin C-terminal domain 0.0028 PF00091 Tubulin/FtsZ family, GTPase domain 0.0027 PF00018 SH3 domain 0.0013 PF01401 Angiotensin-converting enzyme 0.0012 PF00822 PMP-22/EMP/MP20/Claudin family 0.0012 PF08983 Domain of unknown function (DUF1856), 0.0010 PF01061 ABC-2 type transporter 0.0010 PF02254 TrkA-N domain 0.0010 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0009 PF12497 Estrogen receptor beta 0.0009 PF02159 Oestrogen receptor 0.0005 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0003 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0002 PF00042 Globin SUB498 O-C:C:N 0.1665 PF00155 Aminotransferase class I and II 0.1597 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.1577 PF00266 Aminotransferase class-V 0.1166 PF00464 Serine hydroxymethyltransferase 0.1042 PF00291 Pyridoxal-phosphate dependent enzyme 0.0992 PF00202 Aminotransferase class-III 0.0946 PF01063 Aminotransferase class IV 0.0917 PF00343 Carbohydrate phosphorylase 0.0770 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0770 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0657 PF00294 pfkB family carbohydrate kinase 0.0521 PF00702 haloacid dehalogenase-like hydrolase 0.0386 PF03473 MOSC domain 0.0386 PF03476 MOSC N-terminal beta barrel domain 0.0386 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0385 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0385 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0380 PF01168 Alanine racemase, N-terminal domain 0.0380 PF01212 Beta-eliminating lyase 0.0380 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0380 PF01202 Shikimate kinase 0.0380 PF02347 Glycine cleavage system P-protein 0.0373 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0373 PF02971 Formiminotransferase domain 0.0373 PF04961 Formiminotransferase-cyclodeaminase 0.0366 PF07706 Aminotransferase ubiquitination site 0.0276 PF01596 O-methyltransferase 0.0239 PF00571 CBS domain 0.0096 PF00340 Interleukin-1 / 18 0.0096 PF02394 Interleukin-1 propeptide 0.0086 PF00342 Phosphoglucose isomerase 0.0078 PF00690 Cation transporter/ATPase, N-terminus 0.0078 PF00689 Cation transporting ATPase, C-terminus 0.0064 PF01588 Putative tRNA binding domain 0.0063 PF00576 HIUase/Transthyretin family 0.0058 PF00122 E1-E2 ATPase 0.0055 PF01916 Deoxyhypusine synthase 0.0032 PF00204 DNA gyrase B 0.0032 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0032 PF08070 DTHCT (NUC029), region 0.0028 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0022 PF00149 Calcineurin-like phosphoesterase SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 0.1662 PF00105 Zinc finger, C4 type (two domains), 0.1661 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1622 PF02159 Oestrogen receptor 0.1404 PF00191 Annexin 0.1315 PF02155 Glucocorticoid receptor 0.1150 PF02161 Progesterone receptor 0.0869 PF02166 Androgen receptor 0.0641 PF01735 Lysophospholipase catalytic domain 0.0529 PF00079 Serpin (serine protease inhibitor), 0.0457 PF08035 Opioids neuropeptide 0.0457 PF00976 Corticotropin ACTH domain 0.0457 PF08384 Pro-opiomelanocortin, N-terminal region 0.0316 PF00091 Tubulin/FtsZ family, GTPase domain 0.0316 PF03953 Tubulin C-terminal domain 0.0252 PF00168 C2 domain 0.0224 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0223 PF11825 Protein of unknown function (DUF3345), 0.0181 PF12497 Estrogen receptor beta 0.0122 PF01429 Methyl-CpG binding domain 0.0120 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0119 PF00106 short chain dehydrogenase 0.0117 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0112 PF00643 B-box zinc finger 0.0110 PF00305 Lipoxygenase 0.0106 PF07648 Kazal-type serine protease inhibitor domain 0.0098 PF08491 Squalene epoxidase 0.0096 PF00040 Fibronectin type II domain 0.0094 PF00067 Cytochrome P450 0.0091 PF06327 Domain of Unknown Function (DUF1053), 0.0086 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0086 PF02180 Bcl-2 homology region 4 0.0078 PF00918 Gastrin/cholecystokinin family 0.0078 PF01122 Eukaryotic cobalamin-binding protein 0.0077 PF00653 Inhibitor of Apoptosis domain 0.0075 PF01477 PLAT/LH2 domain 0.0070 PF04622 ERG2 and Sigma1 receptor like protein 0.0061 PF00170 bZIP transcription factor 0.0056 PF02173 pKID domain 0.0055 PF01160 Vertebrate endogenous opioids neuropeptide 0.0055 PF00212 Atrial natriuretic peptide 0.0054 PF00031 Cystatin domain 0.0054 PF00554 Rel homology domain (RHD), 0.0051 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0051 PF03765 CRAL/TRIO, N-terminus 0.0051 PF00650 CRAL/TRIO domain 0.0047 PF01642 Methylmalonyl-CoA mutase 0.0047 PF03308 ArgK protein 0.0047 PF01923 Cobalamin adenosyltransferase 0.0047 PF00656 Caspase domain 0.0047 PF00762 Ferrochelatase 0.0046 PF08377 MAP2/Tau projection domain 0.0046 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0036 PF02310 B12 binding domain 0.0035 PF00377 Prion/Doppel alpha-helical domain 0.0034 PF00884 Sulfatase 0.0033 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0031 PF00969 Class II histocompatibility antigen, beta domain 0.0031 PF00625 Guanylate kinase 0.0031 PF06907 Latexin 0.0031 PF08070 DTHCT (NUC029), region 0.0031 PF03572 Peptidase family S41 0.0031 PF00204 DNA gyrase B 0.0031 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0031 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0028 PF00183 Hsp90 protein 0.0027 PF00531 Death domain 0.0026 PF00341 Platelet-derived growth factor (PDGF), 0.0026 PF00340 Interleukin-1 / 18 0.0026 PF02394 Interleukin-1 propeptide 0.0024 PF08763 Voltage gated calcium channel IQ domain 0.0022 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0018 PF00714 Interferon gamma 0.0017 PF00489 Interleukin-6/G-CSF/MGF family 0.0015 PF03957 Jun-like transcription factor 0.0015 PF00432 Prenyltransferase and squalene oxidase repeat 0.0015 PF00357 Integrin alpha cytoplasmic region 0.0013 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0012 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0009 PF02803 Thiolase, C-terminal domain 0.0009 PF00108 Thiolase, N-terminal domain 0.0009 PF00890 FAD binding domain 0.0008 PF00019 Transforming growth factor beta like domain 0.0008 PF00020 TNFR/NGFR cysteine-rich region 0.0008 PF00688 TGF-beta propeptide 0.0008 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0008 PF00439 Bromodomain 0.0008 PF01244 Membrane dipeptidase (Peptidase family M19), 0.0008 PF01327 Polypeptide deformylase 0.0005 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0005 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0003 PF08441 Integrin alpha 0.0003 PF01425 Amidase 0.0002 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0001 PF00229 TNF(Tumour Necrosis Factor), family SUB554 O=C-C=C 0.1661 PF03098 Animal haem peroxidase 0.1657 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1657 PF08070 DTHCT (NUC029), region 0.1657 PF00204 DNA gyrase B 0.0942 PF00191 Annexin 0.0827 PF02155 Glucocorticoid receptor 0.0775 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0700 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0694 PF00105 Zinc finger, C4 type (two domains), 0.0683 PF00273 Serum albumin family 0.0593 PF00102 Protein-tyrosine phosphatase 0.0467 PF07884 Vitamin K epoxide reductase family 0.0312 PF01735 Lysophospholipase catalytic domain 0.0292 PF00005 ABC transporter 0.0277 PF06512 Sodium ion transport-associated 0.0263 PF02161 Progesterone receptor 0.0233 PF02525 Flavodoxin-like fold 0.0220 PF00576 HIUase/Transthyretin family 0.0216 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0214 PF00079 Serpin (serine protease inhibitor), 0.0211 PF01268 Formate--tetrahydrofolate ligase 0.0207 PF00464 Serine hydroxymethyltransferase 0.0205 PF02166 Androgen receptor 0.0202 PF00664 ABC transporter transmembrane region 0.0193 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0193 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0191 PF09396 Thrombin light chain 0.0165 PF00051 Kringle domain 0.0165 PF00089 Trypsin 0.0147 PF00554 Rel homology domain (RHD), 0.0140 PF00533 BRCA1 C Terminus (BRCT), domain 0.0140 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0140 PF05406 WGR domain 0.0140 PF08063 PADR1 (NUC008), domain 0.0140 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0125 PF01061 ABC-2 type transporter 0.0123 PF08403 Amino acid permease N-terminal 0.0121 PF00551 Formyl transferase 0.0113 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0108 PF11825 Protein of unknown function (DUF3345), 0.0104 PF00017 SH2 domain 0.0094 PF01571 Aminomethyltransferase folate-binding domain 0.0094 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0064 PF00018 SH3 domain 0.0062 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0062 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0062 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0054 PF02219 Methylenetetrahydrofolate reductase 0.0052 PF00531 Death domain 0.0049 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0035 PF00229 TNF(Tumour Necrosis Factor), family 0.0034 PF00183 Hsp90 protein 0.0025 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0020 PF01467 Cytidylyltransferase 0.0016 PF00343 Carbohydrate phosphorylase 0.0015 PF03024 Folate receptor family 0.0015 PF02911 Formyl transferase, C-terminal domain 0.0010 PF00248 Aldo/keto reductase family 0.0003 PF01180 Dihydroorotate dehydrogenase 0.0001 PF01596 O-methyltransferase SUB411 P(~C)(~C) 0.1658 PF00273 Serum albumin family 0.1283 PF12179 I-kappa-kinase-beta NEMO binding domain 0.1205 PF08534 Redoxin 0.0626 PF00854 POT family 0.0348 PF09396 Thrombin light chain 0.0294 PF02180 Bcl-2 homology region 4 0.0294 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0222 PF02460 Patched family 0.0219 PF03062 MBOAT family 0.0218 PF01731 Arylesterase 0.0209 PF00151 Lipase 0.0173 PF00069 Protein kinase domain 0.0149 PF05649 Peptidase family M13 0.0149 PF01431 Peptidase family M13 0.0148 PF01401 Angiotensin-converting enzyme 0.0146 PF00698 Acyl transferase domain 0.0146 PF08659 KR domain 0.0146 PF00975 Thioesterase domain 0.0146 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0146 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0127 PF01477 PLAT/LH2 domain 0.0120 PF01433 Peptidase family M1 0.0107 PF00051 Kringle domain 0.0104 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0084 PF00576 HIUase/Transthyretin family 0.0081 PF00550 Phosphopantetheine attachment site 0.0081 PF00343 Carbohydrate phosphorylase 0.0070 PF02984 Cyclin, C-terminal domain 0.0070 PF00134 Cyclin, N-terminal domain 0.0070 PF07970 Endoplasmic reticulum vesicle transporter 0.0070 PF12126 Protein of unknown function (DUF3583), 0.0069 PF00059 Lectin C-type domain 0.0064 PF03953 Tubulin C-terminal domain 0.0064 PF03957 Jun-like transcription factor 0.0064 PF00091 Tubulin/FtsZ family, GTPase domain 0.0063 PF00489 Interleukin-6/G-CSF/MGF family 0.0057 PF02423 Ornithine cyclodeaminase/mu-crystallin family 0.0057 PF07645 Calcium-binding EGF domain 0.0052 PF00664 ABC transporter transmembrane region 0.0039 PF00005 ABC transporter 0.0039 PF00170 bZIP transcription factor 0.0036 PF00107 Zinc-binding dehydrogenase 0.0035 PF00643 B-box zinc finger 0.0026 PF00089 Trypsin 0.0018 PF00433 Protein kinase C terminal domain 0.0007 PF00169 PH domain 0.0004 PF00462 Glutaredoxin 0.0004 PF00328 Histidine acid phosphatase 0.0003 PF03098 Animal haem peroxidase SUB383 C(~O)(:C)(:C) 0.1646 PF02159 Oestrogen receptor 0.1313 PF00001 7 transmembrane receptor (rhodopsin family), 0.0985 PF00204 DNA gyrase B 0.0985 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0985 PF08070 DTHCT (NUC029), region 0.0782 PF00576 HIUase/Transthyretin family 0.0695 PF00105 Zinc finger, C4 type (two domains), 0.0673 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0499 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0367 PF12497 Estrogen receptor beta 0.0360 PF00989 PAS fold 0.0285 PF03098 Animal haem peroxidase 0.0269 PF00027 Cyclic nucleotide-binding domain 0.0255 PF00664 ABC transporter transmembrane region 0.0246 PF00005 ABC transporter 0.0228 PF11825 Protein of unknown function (DUF3345), 0.0213 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0212 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0194 PF08674 Acetylcholinesterase tetramerisation domain 0.0184 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0165 PF00135 Carboxylesterase 0.0159 PF00266 Aminotransferase class-V 0.0129 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0129 PF01596 O-methyltransferase 0.0119 PF00186 Dihydrofolate reductase 0.0113 PF01477 PLAT/LH2 domain 0.0111 PF07884 Vitamin K epoxide reductase family 0.0103 PF00702 haloacid dehalogenase-like hydrolase 0.0100 PF00155 Aminotransferase class I and II 0.0092 PF08384 Pro-opiomelanocortin, N-terminal region 0.0092 PF00976 Corticotropin ACTH domain 0.0092 PF08035 Opioids neuropeptide 0.0070 PF00656 Caspase domain 0.0066 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0064 PF00305 Lipoxygenase 0.0064 PF00183 Hsp90 protein 0.0063 PF08983 Domain of unknown function (DUF1856), 0.0058 PF00273 Serum albumin family 0.0057 PF08441 Integrin alpha 0.0057 PF03765 CRAL/TRIO, N-terminus 0.0057 PF00643 B-box zinc finger 0.0057 PF00650 CRAL/TRIO domain 0.0048 PF00068 Phospholipase A2 0.0041 PF02394 Interleukin-1 propeptide 0.0041 PF00340 Interleukin-1 / 18 0.0041 PF00294 pfkB family carbohydrate kinase 0.0041 PF03062 MBOAT family 0.0041 PF01588 Putative tRNA binding domain 0.0033 PF00357 Integrin alpha cytoplasmic region 0.0012 PF00291 Pyridoxal-phosphate dependent enzyme 0.0011 PF07885 Ion channel 0.0009 PF00102 Protein-tyrosine phosphatase 0.0009 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0009 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0009 PF00151 Lipase 0.0007 PF07966 A1 Propeptide SUB681 O-C-C-C-C-C 0.1645 PF02159 Oestrogen receptor 0.1302 PF00105 Zinc finger, C4 type (two domains), 0.1280 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0744 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0744 PF08070 DTHCT (NUC029), region 0.0744 PF00191 Annexin 0.0744 PF00204 DNA gyrase B 0.0712 PF02155 Glucocorticoid receptor 0.0584 PF00001 7 transmembrane receptor (rhodopsin family), 0.0418 PF02161 Progesterone receptor 0.0387 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0367 PF00079 Serpin (serine protease inhibitor), 0.0351 PF03953 Tubulin C-terminal domain 0.0351 PF00091 Tubulin/FtsZ family, GTPase domain 0.0327 PF01735 Lysophospholipase catalytic domain 0.0295 PF00273 Serum albumin family 0.0277 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0275 PF03098 Animal haem peroxidase 0.0241 PF02166 Androgen receptor 0.0229 PF00005 ABC transporter 0.0223 PF00989 PAS fold 0.0219 PF08384 Pro-opiomelanocortin, N-terminal region 0.0219 PF00976 Corticotropin ACTH domain 0.0219 PF08035 Opioids neuropeptide 0.0218 PF12497 Estrogen receptor beta 0.0204 PF00664 ABC transporter transmembrane region 0.0186 PF00027 Cyclic nucleotide-binding domain 0.0149 PF01401 Angiotensin-converting enzyme 0.0136 PF00168 C2 domain 0.0104 PF03414 Glycosyltransferase family 6 0.0098 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0097 PF00576 HIUase/Transthyretin family 0.0094 PF01477 PLAT/LH2 domain 0.0092 PF02806 Alpha amylase, C-terminal all-beta domain 0.0087 PF00822 PMP-22/EMP/MP20/Claudin family 0.0085 PF00102 Protein-tyrosine phosphatase 0.0078 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0071 PF00067 Cytochrome P450 0.0059 PF01063 Aminotransferase class IV 0.0052 PF07966 A1 Propeptide 0.0050 PF11825 Protein of unknown function (DUF3345), 0.0045 PF00155 Aminotransferase class I and II 0.0042 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0041 PF00026 Eukaryotic aspartyl protease 0.0035 PF00305 Lipoxygenase 0.0031 PF01842 ACT domain 0.0029 PF07648 Kazal-type serine protease inhibitor domain 0.0028 PF00557 Metallopeptidase family M24 0.0027 PF00303 Thymidylate synthase 0.0027 PF00202 Aminotransferase class-III 0.0025 PF00151 Lipase 0.0023 PF00183 Hsp90 protein 0.0021 PF00128 Alpha amylase, catalytic domain 0.0017 PF01061 ABC-2 type transporter 0.0016 PF02394 Interleukin-1 propeptide 0.0016 PF00340 Interleukin-1 / 18 0.0015 PF00059 Lectin C-type domain 0.0014 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0014 PF08763 Voltage gated calcium channel IQ domain 0.0013 PF01268 Formate--tetrahydrofolate ligase 0.0012 PF00464 Serine hydroxymethyltransferase 0.0011 PF01126 Heme oxygenase 0.0011 PF08441 Integrin alpha 0.0010 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0010 PF05649 Peptidase family M13 0.0010 PF01431 Peptidase family M13 0.0010 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0010 PF00643 B-box zinc finger 0.0008 PF00229 TNF(Tumour Necrosis Factor), family 0.0008 PF00248 Aldo/keto reductase family 0.0004 PF00175 Oxidoreductase NAD-binding domain 0.0004 PF02260 FATC domain 0.0004 PF02259 FAT domain 0.0004 PF08771 Rapamycin binding domain 0.0004 PF00291 Pyridoxal-phosphate dependent enzyme 0.0003 PF00571 CBS domain 0.0003 PF02898 Nitric oxide synthase, oxygenase domain 0.0003 PF00650 CRAL/TRIO domain 0.0003 PF00733 Asparagine synthase 0.0003 PF03765 CRAL/TRIO, N-terminus 0.0002 PF07706 Aminotransferase ubiquitination site 0.0002 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0002 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0002 PF03171 2OG-Fe(II), oxygenase superfamily 0.0002 PF02180 Bcl-2 homology region 4 0.0002 PF00667 FAD binding domain 0.0002 PF00258 Flavodoxin 0.0002 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0002 PF00071 Ras family 0.0002 PF00266 Aminotransferase class-V 0.0001 PF02798 Glutathione S-transferase, N-terminal domain 0.0001 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB657 C-C-N-C-C 0.1634 PF00001 7 transmembrane receptor (rhodopsin family), 0.0429 PF03073 TspO/MBR family 0.0280 PF00209 Sodium:neurotransmitter symporter family 0.0277 PF01401 Angiotensin-converting enzyme 0.0272 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0269 PF06512 Sodium ion transport-associated 0.0258 PF00005 ABC transporter 0.0225 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0221 PF00664 ABC transporter transmembrane region 0.0172 PF00989 PAS fold 0.0159 PF01593 Flavin containing amine oxidoreductase 0.0156 PF00520 Ion transport protein 0.0152 PF00069 Protein kinase domain 0.0144 PF00186 Dihydrofolate reductase 0.0141 PF00027 Cyclic nucleotide-binding domain 0.0141 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0141 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0114 PF01048 Phosphorylase superfamily 0.0087 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0068 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0068 PF00204 DNA gyrase B 0.0068 PF08070 DTHCT (NUC029), region 0.0065 PF00091 Tubulin/FtsZ family, GTPase domain 0.0065 PF03953 Tubulin C-terminal domain 0.0050 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0050 PF02180 Bcl-2 homology region 4 0.0044 PF01061 ABC-2 type transporter 0.0044 PF08983 Domain of unknown function (DUF1856), 0.0042 PF00017 SH2 domain 0.0019 PF08491 Squalene epoxidase 0.0018 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0018 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0016 PF08919 F-actin binding 0.0015 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0011 PF00018 SH3 domain 0.0011 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0011 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0007 PF02223 Thymidylate kinase 0.0007 PF01467 Cytidylyltransferase 0.0004 PF00962 Adenosine/AMP deaminase 0.0002 PF01126 Heme oxygenase 0.0002 PF09396 Thrombin light chain 0.0001 PF00042 Globin SUB452 C(-N)(=O) 0.1632 PF01401 Angiotensin-converting enzyme 0.1037 PF03073 TspO/MBR family 0.1017 PF09396 Thrombin light chain 0.0862 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0687 PF01471 Putative peptidoglycan binding domain 0.0687 PF00045 Hemopexin 0.0649 PF00102 Protein-tyrosine phosphatase 0.0626 PF02798 Glutathione S-transferase, N-terminal domain 0.0609 PF00043 Glutathione S-transferase, C-terminal domain 0.0605 PF00413 Matrixin 0.0479 PF01431 Peptidase family M13 0.0479 PF05649 Peptidase family M13 0.0388 PF08983 Domain of unknown function (DUF1856), 0.0386 PF01048 Phosphorylase superfamily 0.0379 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0289 PF01590 GAF domain 0.0274 PF00303 Thymidylate synthase 0.0217 PF00255 Glutathione peroxidase 0.0174 PF00051 Kringle domain 0.0152 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0147 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0144 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0144 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0142 PF06512 Sodium ion transport-associated 0.0130 PF01268 Formate--tetrahydrofolate ligase 0.0123 PF00854 POT family 0.0110 PF00551 Formyl transferase 0.0086 PF01808 AICARFT/IMPCHase bienzyme 0.0052 PF00868 Transglutaminase family 0.0052 PF01841 Transglutaminase-like superfamily 0.0052 PF00927 Transglutaminase family, C-terminal ig like domain 0.0048 PF00026 Eukaryotic aspartyl protease 0.0047 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0047 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0047 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0044 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0037 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0037 PF01571 Aminomethyltransferase folate-binding domain 0.0036 PF07966 A1 Propeptide 0.0019 PF00089 Trypsin 0.0010 PF02769 AIR synthase related protein, C-terminal domain 0.0010 PF00586 AIR synthase related protein, N-terminal domain 0.0002 PF02142 MGS-like domain SUB432 C(-C)(-C)(=N) 0.1612 PF03073 TspO/MBR family 0.1188 PF00069 Protein kinase domain 0.1100 PF00186 Dihydrofolate reductase 0.1018 PF01048 Phosphorylase superfamily 0.0758 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0570 PF00478 IMP dehydrogenase / GMP reductase domain 0.0494 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0415 PF03953 Tubulin C-terminal domain 0.0415 PF00091 Tubulin/FtsZ family, GTPase domain 0.0403 PF00571 CBS domain 0.0359 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0359 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0305 PF00962 Adenosine/AMP deaminase 0.0271 PF01126 Heme oxygenase 0.0245 PF01590 GAF domain 0.0156 PF08240 Alcohol dehydrogenase GroES-like domain 0.0156 PF00156 Phosphoribosyl transferase domain 0.0152 PF00017 SH2 domain 0.0141 PF00042 Globin 0.0127 PF00107 Zinc-binding dehydrogenase 0.0117 PF00018 SH3 domain 0.0109 PF00858 Amiloride-sensitive sodium channel 0.0102 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0092 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0069 PF00343 Carbohydrate phosphorylase 0.0068 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0068 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0061 PF02267 ADP-ribosyl cyclase 0.0049 PF00106 short chain dehydrogenase 0.0037 PF08919 F-actin binding 0.0021 PF00005 ABC transporter 0.0009 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0004 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0004 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0004 PF02771 Acyl-CoA dehydrogenase, N-terminal domain SUB541 C-N-C-[#1] 0.1608 PF00001 7 transmembrane receptor (rhodopsin family), 0.0641 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0530 PF00209 Sodium:neurotransmitter symporter family 0.0381 PF03073 TspO/MBR family 0.0313 PF01401 Angiotensin-converting enzyme 0.0227 PF00005 ABC transporter 0.0196 PF00664 ABC transporter transmembrane region 0.0186 PF00989 PAS fold 0.0165 PF00186 Dihydrofolate reductase 0.0157 PF00027 Cyclic nucleotide-binding domain 0.0154 PF02223 Thymidylate kinase 0.0132 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0128 PF01048 Phosphorylase superfamily 0.0108 PF00069 Protein kinase domain 0.0103 PF06512 Sodium ion transport-associated 0.0095 PF01431 Peptidase family M13 0.0095 PF05649 Peptidase family M13 0.0080 PF00520 Ion transport protein 0.0073 PF00017 SH2 domain 0.0071 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0071 PF02180 Bcl-2 homology region 4 0.0066 PF02267 ADP-ribosyl cyclase 0.0066 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0066 PF08983 Domain of unknown function (DUF1856), 0.0057 PF01007 Inward rectifier potassium channel 0.0041 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0038 PF01842 ACT domain 0.0037 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0036 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0036 PF00464 Serine hydroxymethyltransferase 0.0031 PF01061 ABC-2 type transporter 0.0030 PF01467 Cytidylyltransferase 0.0030 PF00018 SH3 domain 0.0029 PF00255 Glutathione peroxidase 0.0028 PF02798 Glutathione S-transferase, N-terminal domain 0.0028 PF00303 Thymidylate synthase 0.0026 PF01234 NNMT/PNMT/TEMT family 0.0026 PF08919 F-actin binding 0.0026 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0026 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0022 PF00043 Glutathione S-transferase, C-terminal domain 0.0022 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0022 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0018 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0016 PF01590 GAF domain 0.0015 PF00551 Formyl transferase 0.0015 PF03807 NADP oxidoreductase coenzyme F420-dependent 0.0012 PF08491 Squalene epoxidase 0.0009 PF08441 Integrin alpha 0.0009 PF00088 Trefoil (P-type), domain 0.0009 PF01055 Glycosyl hydrolases family 31 0.0007 PF09396 Thrombin light chain 0.0007 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0006 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0006 PF08063 PADR1 (NUC008), domain 0.0006 PF00533 BRCA1 C Terminus (BRCT), domain 0.0006 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0006 PF05406 WGR domain 0.0006 PF02173 pKID domain 0.0006 PF01687 Riboflavin kinase 0.0006 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0006 PF01808 AICARFT/IMPCHase bienzyme 0.0006 PF07966 A1 Propeptide 0.0005 PF06464 DMAP1-binding Domain 0.0005 PF01122 Eukaryotic cobalamin-binding protein 0.0005 PF08403 Amino acid permease N-terminal 0.0005 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0005 PF00026 Eukaryotic aspartyl protease 0.0005 PF01426 BAH domain 0.0005 PF01571 Aminomethyltransferase folate-binding domain 0.0005 PF00357 Integrin alpha cytoplasmic region 0.0005 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0005 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0005 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0005 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0005 PF02008 CXXC zinc finger domain 0.0002 PF08070 DTHCT (NUC029), region 0.0002 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0002 PF00204 DNA gyrase B 0.0002 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0002 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0001 PF00755 Choline/Carnitine o-acyltransferase 0.0001 PF01268 Formate--tetrahydrofolate ligase 0.0001 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment SUB700 O-C-C-C-C-C(C)-C 0.1607 PF02159 Oestrogen receptor 0.1164 PF00105 Zinc finger, C4 type (two domains), 0.1153 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1010 PF00001 7 transmembrane receptor (rhodopsin family), 0.0985 PF08070 DTHCT (NUC029), region 0.0985 PF00204 DNA gyrase B 0.0985 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0811 PF00191 Annexin 0.0743 PF02155 Glucocorticoid receptor 0.0630 PF02161 Progesterone receptor 0.0450 PF02166 Androgen receptor 0.0413 PF01735 Lysophospholipase catalytic domain 0.0406 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0334 PF00079 Serpin (serine protease inhibitor), 0.0255 PF08384 Pro-opiomelanocortin, N-terminal region 0.0255 PF08035 Opioids neuropeptide 0.0255 PF00976 Corticotropin ACTH domain 0.0215 PF12497 Estrogen receptor beta 0.0197 PF00005 ABC transporter 0.0189 PF01401 Angiotensin-converting enzyme 0.0180 PF00664 ABC transporter transmembrane region 0.0167 PF09396 Thrombin light chain 0.0165 PF00168 C2 domain 0.0130 PF03953 Tubulin C-terminal domain 0.0130 PF00091 Tubulin/FtsZ family, GTPase domain 0.0125 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0123 PF00989 PAS fold 0.0111 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0097 PF00186 Dihydrofolate reductase 0.0095 PF07884 Vitamin K epoxide reductase family 0.0092 PF00027 Cyclic nucleotide-binding domain 0.0059 PF00042 Globin 0.0047 PF00305 Lipoxygenase 0.0046 PF11825 Protein of unknown function (DUF3345), 0.0045 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0045 PF00067 Cytochrome P450 0.0045 PF00051 Kringle domain 0.0038 PF01061 ABC-2 type transporter 0.0036 PF00643 B-box zinc finger 0.0029 PF00229 TNF(Tumour Necrosis Factor), family 0.0029 PF02394 Interleukin-1 propeptide 0.0029 PF00340 Interleukin-1 / 18 0.0027 PF07648 Kazal-type serine protease inhibitor domain 0.0027 PF04622 ERG2 and Sigma1 receptor like protein 0.0024 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0021 PF00554 Rel homology domain (RHD), 0.0020 PF01477 PLAT/LH2 domain 0.0019 PF06327 Domain of Unknown Function (DUF1053), 0.0018 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0017 PF00357 Integrin alpha cytoplasmic region 0.0016 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0015 PF08441 Integrin alpha 0.0013 PF03765 CRAL/TRIO, N-terminus 0.0013 PF00650 CRAL/TRIO domain 0.0012 PF07885 Ion channel 0.0011 PF03062 MBOAT family 0.0011 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0010 PF02260 FATC domain 0.0010 PF02259 FAT domain 0.0010 PF08771 Rapamycin binding domain 0.0008 PF00212 Atrial natriuretic peptide 0.0007 PF00341 Platelet-derived growth factor (PDGF), 0.0003 PF02180 Bcl-2 homology region 4 0.0003 PF00452 Apoptosis regulator proteins, Bcl-2 family SUB334 C(~C)(~C)(~C) 0.1593 PF00001 7 transmembrane receptor (rhodopsin family), 0.1335 PF02159 Oestrogen receptor 0.1120 PF00105 Zinc finger, C4 type (two domains), 0.1116 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0887 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0686 PF08070 DTHCT (NUC029), region 0.0686 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0686 PF00204 DNA gyrase B 0.0576 PF00209 Sodium:neurotransmitter symporter family 0.0472 PF03098 Animal haem peroxidase 0.0393 PF06512 Sodium ion transport-associated 0.0361 PF02161 Progesterone receptor 0.0338 PF00191 Annexin 0.0322 PF09396 Thrombin light chain 0.0296 PF00520 Ion transport protein 0.0253 PF02155 Glucocorticoid receptor 0.0243 PF00989 PAS fold 0.0213 PF03073 TspO/MBR family 0.0193 PF00067 Cytochrome P450 0.0182 PF00027 Cyclic nucleotide-binding domain 0.0171 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0168 PF02166 Androgen receptor 0.0119 PF03953 Tubulin C-terminal domain 0.0119 PF00091 Tubulin/FtsZ family, GTPase domain 0.0094 PF01735 Lysophospholipase catalytic domain 0.0090 PF00005 ABC transporter 0.0090 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0090 PF00102 Protein-tyrosine phosphatase 0.0082 PF12497 Estrogen receptor beta 0.0064 PF00186 Dihydrofolate reductase 0.0052 PF00305 Lipoxygenase 0.0052 PF00664 ABC transporter transmembrane region 0.0007 PF07884 Vitamin K epoxide reductase family SUB186 >= 2 any ring size 6 0.1584 PF00001 7 transmembrane receptor (rhodopsin family), 0.1327 PF02159 Oestrogen receptor 0.1113 PF00105 Zinc finger, C4 type (two domains), 0.1109 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0882 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0682 PF00204 DNA gyrase B 0.0682 PF08070 DTHCT (NUC029), region 0.0682 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0572 PF00209 Sodium:neurotransmitter symporter family 0.0469 PF03098 Animal haem peroxidase 0.0390 PF06512 Sodium ion transport-associated 0.0359 PF02161 Progesterone receptor 0.0336 PF00191 Annexin 0.0320 PF09396 Thrombin light chain 0.0294 PF00520 Ion transport protein 0.0251 PF02155 Glucocorticoid receptor 0.0242 PF00989 PAS fold 0.0211 PF03073 TspO/MBR family 0.0192 PF00067 Cytochrome P450 0.0181 PF00027 Cyclic nucleotide-binding domain 0.0170 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0167 PF02166 Androgen receptor 0.0118 PF00091 Tubulin/FtsZ family, GTPase domain 0.0118 PF03953 Tubulin C-terminal domain 0.0093 PF01735 Lysophospholipase catalytic domain 0.0090 PF00005 ABC transporter 0.0089 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0089 PF00102 Protein-tyrosine phosphatase 0.0082 PF12497 Estrogen receptor beta 0.0063 PF00186 Dihydrofolate reductase 0.0052 PF00305 Lipoxygenase 0.0052 PF00664 ABC transporter transmembrane region 0.0007 PF07884 Vitamin K epoxide reductase family SUB391 N(~C)(~C) 0.1576 PF00001 7 transmembrane receptor (rhodopsin family), 0.0628 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0519 PF00209 Sodium:neurotransmitter symporter family 0.0374 PF03073 TspO/MBR family 0.0307 PF01401 Angiotensin-converting enzyme 0.0223 PF00005 ABC transporter 0.0192 PF00664 ABC transporter transmembrane region 0.0182 PF00989 PAS fold 0.0161 PF00186 Dihydrofolate reductase 0.0154 PF00027 Cyclic nucleotide-binding domain 0.0151 PF02223 Thymidylate kinase 0.0130 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0125 PF01048 Phosphorylase superfamily 0.0106 PF00069 Protein kinase domain 0.0101 PF06512 Sodium ion transport-associated 0.0093 PF05649 Peptidase family M13 0.0093 PF01431 Peptidase family M13 0.0079 PF00520 Ion transport protein 0.0072 PF00017 SH2 domain 0.0070 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0070 PF02180 Bcl-2 homology region 4 0.0064 PF08983 Domain of unknown function (DUF1856), 0.0064 PF02267 ADP-ribosyl cyclase 0.0064 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0056 PF01007 Inward rectifier potassium channel 0.0040 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0037 PF01842 ACT domain 0.0036 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0035 PF00464 Serine hydroxymethyltransferase 0.0035 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0031 PF01061 ABC-2 type transporter 0.0029 PF01467 Cytidylyltransferase 0.0029 PF00255 Glutathione peroxidase 0.0029 PF00018 SH3 domain 0.0028 PF00303 Thymidylate synthase 0.0027 PF02798 Glutathione S-transferase, N-terminal domain 0.0026 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0026 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0025 PF08919 F-actin binding 0.0025 PF01234 NNMT/PNMT/TEMT family 0.0022 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0022 PF00043 Glutathione S-transferase, C-terminal domain 0.0022 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0017 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0015 PF01590 GAF domain 0.0014 PF00551 Formyl transferase 0.0014 PF03807 NADP oxidoreductase coenzyme F420-dependent 0.0012 PF08491 Squalene epoxidase 0.0009 PF01055 Glycosyl hydrolases family 31 0.0009 PF00088 Trefoil (P-type), domain 0.0009 PF08441 Integrin alpha 0.0007 PF09396 Thrombin light chain 0.0007 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0006 PF05406 WGR domain 0.0006 PF08063 PADR1 (NUC008), domain 0.0006 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0006 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0006 PF01687 Riboflavin kinase 0.0006 PF07966 A1 Propeptide 0.0006 PF00533 BRCA1 C Terminus (BRCT), domain 0.0006 PF01808 AICARFT/IMPCHase bienzyme 0.0006 PF02173 pKID domain 0.0006 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0005 PF00026 Eukaryotic aspartyl protease 0.0005 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0005 PF01571 Aminomethyltransferase folate-binding domain 0.0005 PF06464 DMAP1-binding Domain 0.0005 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0005 PF01426 BAH domain 0.0005 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0005 PF08403 Amino acid permease N-terminal 0.0005 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0005 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0005 PF02008 CXXC zinc finger domain 0.0005 PF01122 Eukaryotic cobalamin-binding protein 0.0005 PF00357 Integrin alpha cytoplasmic region 0.0002 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0002 PF08070 DTHCT (NUC029), region 0.0002 PF00204 DNA gyrase B 0.0002 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0002 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0001 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0001 PF01268 Formate--tetrahydrofolate ligase 0.0001 PF00755 Choline/Carnitine o-acyltransferase SUB542 O-C:C-C 0.1569 PF02159 Oestrogen receptor 0.1252 PF00001 7 transmembrane receptor (rhodopsin family), 0.0939 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0939 PF08070 DTHCT (NUC029), region 0.0939 PF00204 DNA gyrase B 0.0746 PF00576 HIUase/Transthyretin family 0.0662 PF00105 Zinc finger, C4 type (two domains), 0.0642 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0476 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0350 PF12497 Estrogen receptor beta 0.0343 PF00989 PAS fold 0.0271 PF03098 Animal haem peroxidase 0.0256 PF00027 Cyclic nucleotide-binding domain 0.0243 PF00664 ABC transporter transmembrane region 0.0235 PF00005 ABC transporter 0.0217 PF11825 Protein of unknown function (DUF3345), 0.0203 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0202 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0185 PF08674 Acetylcholinesterase tetramerisation domain 0.0176 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0158 PF00135 Carboxylesterase 0.0151 PF00266 Aminotransferase class-V 0.0123 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0123 PF01596 O-methyltransferase 0.0114 PF00186 Dihydrofolate reductase 0.0108 PF01477 PLAT/LH2 domain 0.0106 PF07884 Vitamin K epoxide reductase family 0.0098 PF00702 haloacid dehalogenase-like hydrolase 0.0095 PF00155 Aminotransferase class I and II 0.0088 PF08035 Opioids neuropeptide 0.0088 PF08384 Pro-opiomelanocortin, N-terminal region 0.0088 PF00976 Corticotropin ACTH domain 0.0067 PF00656 Caspase domain 0.0063 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0061 PF00305 Lipoxygenase 0.0061 PF00183 Hsp90 protein 0.0060 PF08983 Domain of unknown function (DUF1856), 0.0055 PF00273 Serum albumin family 0.0055 PF03765 CRAL/TRIO, N-terminus 0.0055 PF08441 Integrin alpha 0.0055 PF00643 B-box zinc finger 0.0055 PF00650 CRAL/TRIO domain 0.0046 PF00068 Phospholipase A2 0.0039 PF00340 Interleukin-1 / 18 0.0039 PF03062 MBOAT family 0.0039 PF02394 Interleukin-1 propeptide 0.0039 PF01588 Putative tRNA binding domain 0.0039 PF00294 pfkB family carbohydrate kinase 0.0031 PF00357 Integrin alpha cytoplasmic region 0.0011 PF00291 Pyridoxal-phosphate dependent enzyme 0.0011 PF07885 Ion channel 0.0009 PF00151 Lipase 0.0009 PF00102 Protein-tyrosine phosphatase 0.0009 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0009 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0007 PF07966 A1 Propeptide SUB382 C(~O)(:C) 0.1543 PF02159 Oestrogen receptor 0.1231 PF00001 7 transmembrane receptor (rhodopsin family), 0.0923 PF08070 DTHCT (NUC029), region 0.0923 PF00204 DNA gyrase B 0.0923 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0734 PF00576 HIUase/Transthyretin family 0.0651 PF00105 Zinc finger, C4 type (two domains), 0.0631 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0468 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0344 PF12497 Estrogen receptor beta 0.0337 PF00989 PAS fold 0.0267 PF03098 Animal haem peroxidase 0.0252 PF00027 Cyclic nucleotide-binding domain 0.0239 PF00664 ABC transporter transmembrane region 0.0231 PF00005 ABC transporter 0.0214 PF11825 Protein of unknown function (DUF3345), 0.0200 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0199 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0182 PF08674 Acetylcholinesterase tetramerisation domain 0.0173 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0155 PF00135 Carboxylesterase 0.0149 PF00266 Aminotransferase class-V 0.0121 PF01596 O-methyltransferase 0.0121 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0112 PF00186 Dihydrofolate reductase 0.0106 PF01477 PLAT/LH2 domain 0.0104 PF07884 Vitamin K epoxide reductase family 0.0096 PF00702 haloacid dehalogenase-like hydrolase 0.0093 PF00155 Aminotransferase class I and II 0.0087 PF00976 Corticotropin ACTH domain 0.0087 PF08384 Pro-opiomelanocortin, N-terminal region 0.0087 PF08035 Opioids neuropeptide 0.0066 PF00656 Caspase domain 0.0062 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0060 PF00305 Lipoxygenase 0.0060 PF00183 Hsp90 protein 0.0059 PF08983 Domain of unknown function (DUF1856), 0.0054 PF00650 CRAL/TRIO domain 0.0054 PF08441 Integrin alpha 0.0054 PF00643 B-box zinc finger 0.0054 PF00273 Serum albumin family 0.0054 PF03765 CRAL/TRIO, N-terminus 0.0045 PF00068 Phospholipase A2 0.0038 PF00294 pfkB family carbohydrate kinase 0.0038 PF01588 Putative tRNA binding domain 0.0038 PF00340 Interleukin-1 / 18 0.0038 PF02394 Interleukin-1 propeptide 0.0038 PF03062 MBOAT family 0.0031 PF00357 Integrin alpha cytoplasmic region 0.0011 PF00291 Pyridoxal-phosphate dependent enzyme 0.0011 PF07885 Ion channel 0.0009 PF00102 Protein-tyrosine phosphatase 0.0008 PF00151 Lipase 0.0008 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0008 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0007 PF07966 A1 Propeptide SUB539 N=C-C-C 0.1538 PF03073 TspO/MBR family 0.1133 PF00069 Protein kinase domain 0.1050 PF00186 Dihydrofolate reductase 0.0972 PF01048 Phosphorylase superfamily 0.0724 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0544 PF00478 IMP dehydrogenase / GMP reductase domain 0.0471 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0396 PF03953 Tubulin C-terminal domain 0.0396 PF00091 Tubulin/FtsZ family, GTPase domain 0.0385 PF00571 CBS domain 0.0342 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0342 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0291 PF00962 Adenosine/AMP deaminase 0.0259 PF01126 Heme oxygenase 0.0233 PF01590 GAF domain 0.0149 PF00156 Phosphoribosyl transferase domain 0.0149 PF08240 Alcohol dehydrogenase GroES-like domain 0.0145 PF00017 SH2 domain 0.0134 PF00042 Globin 0.0121 PF00107 Zinc-binding dehydrogenase 0.0112 PF00018 SH3 domain 0.0104 PF00858 Amiloride-sensitive sodium channel 0.0097 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0088 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0066 PF00343 Carbohydrate phosphorylase 0.0065 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0065 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0058 PF02267 ADP-ribosyl cyclase 0.0046 PF00106 short chain dehydrogenase 0.0035 PF08919 F-actin binding 0.0020 PF00005 ABC transporter 0.0009 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0004 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0004 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0004 PF02770 Acyl-CoA dehydrogenase, middle domain SUB409 O(~H)(~S) 0.1530 PF08702 Fibrinogen alpha/beta chain family 0.1530 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0957 PF00273 Serum albumin family 0.0873 PF12160 Fibrinogen alpha C domain 0.0872 PF09396 Thrombin light chain 0.0664 PF00167 Fibroblast growth factor 0.0586 PF01459 Eukaryotic porin 0.0516 PF00079 Serpin (serine protease inhibitor), 0.0511 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0437 PF00051 Kringle domain 0.0423 PF00089 Trypsin 0.0261 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0258 PF02146 Sir2 family 0.0214 PF00024 PAN domain 0.0210 PF00405 Transferrin 0.0134 PF00854 POT family 0.0113 PF02806 Alpha amylase, C-terminal all-beta domain 0.0108 PF00690 Cation transporter/ATPase, N-terminus 0.0108 PF00689 Cation transporting ATPase, C-terminus 0.0103 PF00059 Lectin C-type domain 0.0096 PF00122 E1-E2 ATPase 0.0092 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0089 PF00128 Alpha amylase, catalytic domain 0.0074 PF00702 haloacid dehalogenase-like hydrolase 0.0068 PF00084 Sushi domain (SCR repeat), 0.0067 PF00002 7 transmembrane receptor (Secretin family), 0.0067 PF02793 Hormone receptor domain 0.0065 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0061 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0061 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0061 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0061 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0058 PF00088 Trefoil (P-type), domain 0.0058 PF01055 Glycosyl hydrolases family 31 0.0056 PF09193 Cholecystokinin A receptor, N-terminal 0.0053 PF01068 ATP dependent DNA ligase domain 0.0053 PF04679 ATP dependent DNA ligase C terminal region 0.0046 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0044 PF00578 AhpC/TSA family 0.0044 PF00188 Cysteine-rich secretory protein family 0.0044 PF01370 NAD dependent epimerase/dehydratase family 0.0044 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0042 PF01323 DSBA-like thioredoxin domain 0.0042 PF01731 Arylesterase 0.0040 PF03414 Glycosyltransferase family 6 0.0039 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0039 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0038 PF02259 FAT domain 0.0038 PF08771 Rapamycin binding domain 0.0038 PF02260 FATC domain 0.0035 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0035 PF02460 Patched family 0.0035 PF02180 Bcl-2 homology region 4 0.0033 PF03489 Saposin-like type B, region 2 0.0033 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0032 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0031 PF01835 MG2 domain 0.0031 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0031 PF07678 A-macroglobulin complement component 0.0031 PF07677 A-macroglobulin receptor 0.0030 PF03062 MBOAT family 0.0030 PF00439 Bromodomain 0.0030 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0028 PF06617 M-phase inducer phosphatase 0.0028 PF00581 Rhodanese-like domain 0.0025 PF03073 TspO/MBR family 0.0025 PF03770 Inositol polyphosphate kinase 0.0024 PF01652 Eukaryotic initiation factor 4E 0.0024 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0023 PF00169 PH domain 0.0021 PF03953 Tubulin C-terminal domain 0.0021 PF00091 Tubulin/FtsZ family, GTPase domain 0.0019 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0019 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0019 PF02233 NAD(P), transhydrogenase beta subunit 0.0018 PF08983 Domain of unknown function (DUF1856), 0.0018 PF02267 ADP-ribosyl cyclase 0.0015 PF00248 Aldo/keto reductase family 0.0015 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0014 PF00151 Lipase 0.0013 PF00378 Enoyl-CoA hydratase/isomerase family 0.0013 PF00106 short chain dehydrogenase 0.0013 PF02803 Thiolase, C-terminal domain 0.0013 PF00431 CUB domain 0.0013 PF00675 Insulinase (Peptidase family M16), 0.0013 PF00108 Thiolase, N-terminal domain 0.0013 PF05193 Peptidase M16 inactive domain 0.0011 PF00171 Aldehyde dehydrogenase family 0.0010 PF00406 Adenylate kinase 0.0010 PF07645 Calcium-binding EGF domain 0.0010 PF03360 Glycosyltransferase family 43 0.0009 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0009 PF00779 BTK motif 0.0009 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0009 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0008 PF01122 Eukaryotic cobalamin-binding protein 0.0007 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0007 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0006 PF01433 Peptidase family M1 0.0006 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0006 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0005 PF02223 Thymidylate kinase 0.0005 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0005 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0001 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0001 PF00975 Thioesterase domain 0.0001 PF01852 START domain 0.0001 PF00583 Acetyltransferase (GNAT), family 0.0001 PF00698 Acyl transferase domain 0.0001 PF01923 Cobalamin adenosyltransferase 0.0001 PF01642 Methylmalonyl-CoA mutase 0.0001 PF03308 ArgK protein 0.0001 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0001 PF08659 KR domain SUB652 O-C:C:C-C 0.1530 PF02159 Oestrogen receptor 0.1221 PF00001 7 transmembrane receptor (rhodopsin family), 0.0915 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0915 PF08070 DTHCT (NUC029), region 0.0915 PF00204 DNA gyrase B 0.0727 PF00576 HIUase/Transthyretin family 0.0646 PF00105 Zinc finger, C4 type (two domains), 0.0626 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0464 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0341 PF12497 Estrogen receptor beta 0.0334 PF00989 PAS fold 0.0265 PF03098 Animal haem peroxidase 0.0250 PF00027 Cyclic nucleotide-binding domain 0.0237 PF00664 ABC transporter transmembrane region 0.0229 PF00005 ABC transporter 0.0212 PF11825 Protein of unknown function (DUF3345), 0.0198 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0197 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0180 PF08674 Acetylcholinesterase tetramerisation domain 0.0171 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0154 PF00135 Carboxylesterase 0.0148 PF00266 Aminotransferase class-V 0.0120 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0120 PF01596 O-methyltransferase 0.0111 PF00186 Dihydrofolate reductase 0.0105 PF01477 PLAT/LH2 domain 0.0104 PF07884 Vitamin K epoxide reductase family 0.0096 PF00702 haloacid dehalogenase-like hydrolase 0.0093 PF00155 Aminotransferase class I and II 0.0086 PF00976 Corticotropin ACTH domain 0.0086 PF08035 Opioids neuropeptide 0.0086 PF08384 Pro-opiomelanocortin, N-terminal region 0.0065 PF00656 Caspase domain 0.0062 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0060 PF00183 Hsp90 protein 0.0059 PF00305 Lipoxygenase 0.0058 PF08983 Domain of unknown function (DUF1856), 0.0054 PF00273 Serum albumin family 0.0053 PF08441 Integrin alpha 0.0053 PF00643 B-box zinc finger 0.0053 PF03765 CRAL/TRIO, N-terminus 0.0053 PF00650 CRAL/TRIO domain 0.0045 PF00068 Phospholipase A2 0.0038 PF01588 Putative tRNA binding domain 0.0038 PF00294 pfkB family carbohydrate kinase 0.0038 PF02394 Interleukin-1 propeptide 0.0038 PF03062 MBOAT family 0.0038 PF00340 Interleukin-1 / 18 0.0030 PF00357 Integrin alpha cytoplasmic region 0.0011 PF00291 Pyridoxal-phosphate dependent enzyme 0.0010 PF07885 Ion channel 0.0009 PF00102 Protein-tyrosine phosphatase 0.0008 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0008 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0008 PF00151 Lipase 0.0007 PF07966 A1 Propeptide SUB820 CC1C(O)CCCC1 0.1514 PF00191 Annexin 0.1315 PF02155 Glucocorticoid receptor 0.0724 PF01735 Lysophospholipase catalytic domain 0.0703 PF00079 Serpin (serine protease inhibitor), 0.0443 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0432 PF00105 Zinc finger, C4 type (two domains), 0.0411 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0411 PF08070 DTHCT (NUC029), region 0.0411 PF00204 DNA gyrase B 0.0296 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0272 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0268 PF00168 C2 domain 0.0224 PF00091 Tubulin/FtsZ family, GTPase domain 0.0224 PF03953 Tubulin C-terminal domain 0.0219 PF00102 Protein-tyrosine phosphatase 0.0168 PF00557 Metallopeptidase family M24 0.0154 PF02180 Bcl-2 homology region 4 0.0154 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0133 PF00554 Rel homology domain (RHD), 0.0118 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0115 PF00183 Hsp90 protein 0.0115 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0113 PF00229 TNF(Tumour Necrosis Factor), family 0.0094 PF12497 Estrogen receptor beta 0.0093 PF08035 Opioids neuropeptide 0.0093 PF00976 Corticotropin ACTH domain 0.0093 PF08384 Pro-opiomelanocortin, N-terminal region 0.0089 PF03062 MBOAT family 0.0087 PF02173 pKID domain 0.0078 PF01477 PLAT/LH2 domain 0.0074 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0073 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0071 PF07690 Major Facilitator Superfamily 0.0064 PF02159 Oestrogen receptor 0.0061 PF00170 bZIP transcription factor 0.0059 PF00005 ABC transporter 0.0054 PF00656 Caspase domain 0.0054 PF00664 ABC transporter transmembrane region 0.0053 PF00151 Lipase 0.0052 PF01347 Lipoprotein amino terminal region 0.0051 PF02260 FATC domain 0.0051 PF02259 FAT domain 0.0051 PF08771 Rapamycin binding domain 0.0048 PF03171 2OG-Fe(II), oxygenase superfamily 0.0047 PF00341 Platelet-derived growth factor (PDGF), 0.0045 PF00531 Death domain 0.0043 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0041 PF07648 Kazal-type serine protease inhibitor domain 0.0038 PF02525 Flavodoxin-like fold 0.0037 PF00094 von Willebrand factor type D domain 0.0037 PF08742 C8 domain 0.0037 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0037 PF02025 Interleukin 5 0.0036 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0035 PF00305 Lipoxygenase 0.0035 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0034 PF00176 SNF2 family N-terminal domain 0.0033 PF00271 Helicase conserved C-terminal domain 0.0032 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0032 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0032 PF00975 Thioesterase domain 0.0032 PF08659 KR domain 0.0032 PF00698 Acyl transferase domain 0.0030 PF00432 Prenyltransferase and squalene oxidase repeat 0.0028 PF00493 MCM2/3/5 family 0.0025 PF01596 O-methyltransferase 0.0022 PF02758 PAAD/DAPIN/Pyrin domain 0.0020 PF01391 Collagen triple helix repeat (20 copies), 0.0020 PF00023 Ankyrin repeat 0.0018 PF00224 Pyruvate kinase, barrel domain 0.0018 PF02887 Pyruvate kinase, alpha/beta domain 0.0017 PF00377 Prion/Doppel alpha-helical domain 0.0017 PF03360 Glycosyltransferase family 43 0.0016 PF00040 Fibronectin type II domain 0.0016 PF00167 Fibroblast growth factor 0.0016 PF02166 Androgen receptor 0.0016 PF00489 Interleukin-6/G-CSF/MGF family 0.0014 PF00274 Fructose-bisphosphate aldolase class-I 0.0013 PF00354 Pentaxin family 0.0013 PF02394 Interleukin-1 propeptide 0.0013 PF00340 Interleukin-1 / 18 0.0013 PF02460 Patched family 0.0013 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0013 PF07884 Vitamin K epoxide reductase family 0.0012 PF01061 ABC-2 type transporter 0.0010 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0010 PF00071 Ras family 0.0010 PF00969 Class II histocompatibility antigen, beta domain 0.0010 PF02161 Progesterone receptor 0.0009 PF12491 Apolipoprotein B100 C terminal 0.0009 PF06448 Domain of Unknown Function (DUF1081), 0.0009 PF03623 Focal adhesion targeting region 0.0008 PF00643 B-box zinc finger 0.0008 PF00622 SPRY domain 0.0007 PF01023 S-100/ICaBP type calcium binding domain 0.0007 PF00067 Cytochrome P450 0.0006 PF00074 Pancreatic ribonuclease 0.0005 PF00342 Phosphoglucose isomerase 0.0002 PF00550 Phosphopantetheine attachment site 0.0001 PF01388 ARID/BRIGHT DNA binding domain 0.0001 PF08429 PLU-1-like protein 0.0001 PF02373 JmjC domain 0.0001 PF02375 jmjN domain 0.0001 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0001 PF00860 Permease family 0.0001 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0001 PF00628 PHD-finger 0.0001 PF02928 C5HC2 zinc finger 0.0001 PF01753 MYND finger SUB11 >= 4 C 0.1509 PF00001 7 transmembrane receptor (rhodopsin family), 0.0842 PF00105 Zinc finger, C4 type (two domains), 0.0837 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0791 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0739 PF02159 Oestrogen receptor 0.0480 PF00209 Sodium:neurotransmitter symporter family 0.0332 PF03098 Animal haem peroxidase 0.0311 PF08070 DTHCT (NUC029), region 0.0311 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0311 PF00204 DNA gyrase B 0.0159 PF00091 Tubulin/FtsZ family, GTPase domain 0.0159 PF03953 Tubulin C-terminal domain 0.0158 PF00989 PAS fold 0.0130 PF09396 Thrombin light chain 0.0125 PF00027 Cyclic nucleotide-binding domain 0.0123 PF00005 ABC transporter 0.0112 PF00067 Cytochrome P450 0.0105 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0105 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0088 PF00664 ABC transporter transmembrane region 0.0046 PF00273 Serum albumin family 0.0045 PF02161 Progesterone receptor 0.0040 PF01593 Flavin containing amine oxidoreductase 0.0034 PF03073 TspO/MBR family 0.0028 PF12497 Estrogen receptor beta 0.0025 PF11825 Protein of unknown function (DUF3345), 0.0021 PF02166 Androgen receptor 0.0010 PF00061 Lipocalin / cytosolic fatty-acid binding protein family SUB680 C-C-C-C-C-C 0.1508 PF00001 7 transmembrane receptor (rhodopsin family), 0.0659 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0617 PF02159 Oestrogen receptor 0.0615 PF00105 Zinc finger, C4 type (two domains), 0.0615 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0606 PF03098 Animal haem peroxidase 0.0408 PF00209 Sodium:neurotransmitter symporter family 0.0307 PF06512 Sodium ion transport-associated 0.0199 PF03073 TspO/MBR family 0.0175 PF09396 Thrombin light chain 0.0161 PF00191 Annexin 0.0149 PF00520 Ion transport protein 0.0146 PF00989 PAS fold 0.0122 PF00067 Cytochrome P450 0.0120 PF00005 ABC transporter 0.0116 PF00027 Cyclic nucleotide-binding domain 0.0106 PF02161 Progesterone receptor 0.0103 PF02155 Glucocorticoid receptor 0.0102 PF08070 DTHCT (NUC029), region 0.0102 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0102 PF00204 DNA gyrase B 0.0093 PF00664 ABC transporter transmembrane region 0.0064 PF01593 Flavin containing amine oxidoreductase 0.0049 PF00186 Dihydrofolate reductase 0.0044 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0033 PF01007 Inward rectifier potassium channel 0.0030 PF01735 Lysophospholipase catalytic domain 0.0024 PF00194 Eukaryotic-type carbonic anhydrase 0.0023 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0022 PF12497 Estrogen receptor beta 0.0013 PF11825 Protein of unknown function (DUF3345), 0.0013 PF02166 Androgen receptor 0.0011 PF00305 Lipoxygenase 0.0011 PF00102 Protein-tyrosine phosphatase 0.0011 PF00017 SH2 domain 0.0010 PF03953 Tubulin C-terminal domain 0.0010 PF00091 Tubulin/FtsZ family, GTPase domain 0.0005 PF08403 Amino acid permease N-terminal 0.0003 PF00576 HIUase/Transthyretin family 0.0002 PF00273 Serum albumin family 0.0001 PF07884 Vitamin K epoxide reductase family SUB360 C(~C)(:N)(:N) 0.1507 PF00186 Dihydrofolate reductase 0.0801 PF00069 Protein kinase domain 0.0665 PF00478 IMP dehydrogenase / GMP reductase domain 0.0580 PF08240 Alcohol dehydrogenase GroES-like domain 0.0522 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0516 PF01048 Phosphorylase superfamily 0.0512 PF00107 Zinc-binding dehydrogenase 0.0474 PF00106 short chain dehydrogenase 0.0438 PF00571 CBS domain 0.0336 PF00962 Adenosine/AMP deaminase 0.0314 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0314 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0314 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0314 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0314 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0263 PF00171 Aldehyde dehydrogenase family 0.0214 PF00018 SH3 domain 0.0208 PF00248 Aldo/keto reductase family 0.0198 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0198 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0181 PF02223 Thymidylate kinase 0.0178 PF00156 Phosphoribosyl transferase domain 0.0154 PF00017 SH2 domain 0.0150 PF00501 AMP-binding enzyme 0.0135 PF08919 F-actin binding 0.0114 PF01467 Cytidylyltransferase 0.0091 PF00225 Kinesin motor domain 0.0088 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0088 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0087 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0079 PF01230 HIT domain 0.0076 PF02036 SCP-2 sterol transfer family 0.0076 PF00136 DNA polymerase family B 0.0076 PF12473 Kinesin protein 0.0076 PF00970 Oxidoreductase FAD-binding domain 0.0076 PF08676 MutL C terminal dimerisation domain 0.0076 PF12423 Kinesin protein 1B 0.0076 PF08996 DNA Polymerase alpha zinc finger 0.0076 PF01575 MaoC like domain 0.0076 PF03104 DNA polymerase family B, exonuclease domain 0.0076 PF01119 DNA mismatch repair protein, C-terminal domain 0.0076 PF00498 FHA domain 0.0075 PF03949 Malic enzyme, NAD binding domain 0.0075 PF00390 Malic enzyme, N-terminal domain 0.0069 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0069 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0069 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0069 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0063 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0063 PF00931 NB-ARC domain 0.0063 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0063 PF00400 WD domain, G-beta repeat 0.0063 PF02233 NAD(P), transhydrogenase beta subunit 0.0051 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0049 PF02867 Ribonucleotide reductase, barrel domain 0.0049 PF03477 ATP cone domain 0.0049 PF00317 Ribonucleotide reductase, all-alpha domain 0.0049 PF03770 Inositol polyphosphate kinase 0.0048 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0045 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0040 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0040 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0023 PF01030 Receptor L domain 0.0023 PF00757 Furin-like cysteine rich region 0.0022 PF01268 Formate--tetrahydrofolate ligase 0.0021 PF00858 Amiloride-sensitive sodium channel 0.0014 PF01064 Activin types I and II receptor domain 0.0014 PF08515 Transforming growth factor beta type I GS-motif 0.0014 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0014 PF00378 Enoyl-CoA hydratase/isomerase family 0.0014 PF00676 Dehydrogenase E1 component 0.0009 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0006 PF00005 ABC transporter 0.0003 PF01126 Heme oxygenase 0.0002 PF02525 Flavodoxin-like fold SUB357 C(~C)(:C)(:C) 0.1504 PF00001 7 transmembrane receptor (rhodopsin family), 0.0722 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0500 PF00209 Sodium:neurotransmitter symporter family 0.0435 PF03098 Animal haem peroxidase 0.0400 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0400 PF00204 DNA gyrase B 0.0400 PF08070 DTHCT (NUC029), region 0.0340 PF06512 Sodium ion transport-associated 0.0294 PF00194 Eukaryotic-type carbonic anhydrase 0.0284 PF03073 TspO/MBR family 0.0261 PF00520 Ion transport protein 0.0181 PF00989 PAS fold 0.0162 PF00102 Protein-tyrosine phosphatase 0.0161 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0148 PF09396 Thrombin light chain 0.0148 PF00027 Cyclic nucleotide-binding domain 0.0147 PF00186 Dihydrofolate reductase 0.0143 PF00005 ABC transporter 0.0104 PF00069 Protein kinase domain 0.0103 PF01593 Flavin containing amine oxidoreductase 0.0103 PF00664 ABC transporter transmembrane region 0.0096 PF00576 HIUase/Transthyretin family 0.0064 PF01007 Inward rectifier potassium channel 0.0061 PF08403 Amino acid permease N-terminal 0.0045 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0044 PF00017 SH2 domain 0.0035 PF05649 Peptidase family M13 0.0035 PF01431 Peptidase family M13 0.0031 PF07884 Vitamin K epoxide reductase family 0.0029 PF00018 SH3 domain 0.0012 PF01061 ABC-2 type transporter 0.0011 PF08983 Domain of unknown function (DUF1856), 0.0010 PF00822 PMP-22/EMP/MP20/Claudin family 0.0007 PF01401 Angiotensin-converting enzyme 0.0006 PF12497 Estrogen receptor beta 0.0003 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0001 PF00042 Globin 0.0001 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB534 S-C:C-N 0.1455 PF00194 Eukaryotic-type carbonic anhydrase 0.1102 PF03953 Tubulin C-terminal domain 0.1102 PF00091 Tubulin/FtsZ family, GTPase domain 0.0664 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0664 PF02254 TrkA-N domain 0.0556 PF08403 Amino acid permease N-terminal 0.0534 PF00001 7 transmembrane receptor (rhodopsin family), 0.0234 PF00324 Amino acid permease 0.0179 PF00689 Cation transporting ATPase, C-terminus 0.0179 PF00690 Cation transporter/ATPase, N-terminus 0.0159 PF07884 Vitamin K epoxide reductase family 0.0155 PF00122 E1-E2 ATPase 0.0147 PF00018 SH3 domain 0.0135 PF00520 Ion transport protein 0.0133 PF00702 haloacid dehalogenase-like hydrolase 0.0129 PF00017 SH2 domain 0.0128 PF04679 ATP dependent DNA ligase C terminal region 0.0128 PF01068 ATP dependent DNA ligase domain 0.0126 PF01770 Reduced folate carrier 0.0123 PF08919 F-actin binding 0.0119 PF02038 ATP1G1/PLM/MAT8 family 0.0119 PF00102 Protein-tyrosine phosphatase 0.0089 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0087 PF00536 SAM domain (Sterile alpha motif), 0.0087 PF01404 Ephrin receptor ligand binding domain 0.0073 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0070 PF00854 POT family 0.0061 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0060 PF00478 IMP dehydrogenase / GMP reductase domain 0.0060 PF02865 STAT protein, protein interaction domain 0.0060 PF01017 STAT protein, all-alpha domain 0.0060 PF02864 STAT protein, DNA binding domain 0.0057 PF00656 Caspase domain 0.0057 PF00183 Hsp90 protein 0.0056 PF02059 Interleukin-3 0.0056 PF00377 Prion/Doppel alpha-helical domain 0.0055 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0054 PF00340 Interleukin-1 / 18 0.0054 PF02394 Interleukin-1 propeptide 0.0049 PF00962 Adenosine/AMP deaminase 0.0040 PF01023 S-100/ICaBP type calcium binding domain 0.0040 PF00043 Glutathione S-transferase, C-terminal domain 0.0038 PF02798 Glutathione S-transferase, N-terminal domain 0.0038 PF00156 Phosphoribosyl transferase domain 0.0037 PF09396 Thrombin light chain 0.0036 PF10397 Adenylosuccinate lyase C-terminus 0.0036 PF00069 Protein kinase domain 0.0036 PF03098 Animal haem peroxidase 0.0035 PF00020 TNFR/NGFR cysteine-rich region 0.0032 PF00619 Caspase recruitment domain 0.0032 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0031 PF00958 GMP synthase C terminal domain 0.0030 PF02525 Flavodoxin-like fold 0.0030 PF00341 Platelet-derived growth factor (PDGF), 0.0029 PF00822 PMP-22/EMP/MP20/Claudin family 0.0028 PF00305 Lipoxygenase 0.0025 PF00040 Fibronectin type II domain 0.0024 PF00041 Fibronectin type III domain 0.0024 PF00357 Integrin alpha cytoplasmic region 0.0024 PF12497 Estrogen receptor beta 0.0022 PF00206 Lyase 0.0022 PF00531 Death domain 0.0021 PF02155 Glucocorticoid receptor 0.0019 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0015 PF08441 Integrin alpha 0.0014 PF01734 Patatin-like phospholipase 0.0013 PF01030 Receptor L domain 0.0013 PF00757 Furin-like cysteine rich region 0.0012 PF00117 Glutamine amidotransferase class-I 0.0012 PF00273 Serum albumin family 0.0011 PF01477 PLAT/LH2 domain 0.0011 PF00709 Adenylosuccinate synthetase 0.0009 PF00245 Alkaline phosphatase 0.0009 PF00571 CBS domain 0.0009 PF00310 Glutamine amidotransferases class-II 0.0009 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0009 PF00230 Major intrinsic protein 0.0008 PF01425 Amidase 0.0006 PF00287 Sodium / potassium ATPase beta chain 0.0006 PF01835 MG2 domain 0.0006 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0006 PF07677 A-macroglobulin receptor 0.0006 PF07678 A-macroglobulin complement component 0.0005 PF01582 TIR domain 0.0005 PF01007 Inward rectifier potassium channel 0.0005 PF01731 Arylesterase 0.0005 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0005 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0005 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0004 PF00042 Globin 0.0001 PF05193 Peptidase M16 inactive domain 0.0001 PF11857 Domain of unknown function (DUF3377), 0.0001 PF00557 Metallopeptidase family M24 0.0001 PF00675 Insulinase (Peptidase family M16), SUB572 [#1]-C-O-[#1] 0.1444 PF00191 Annexin 0.1330 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.1260 PF02806 Alpha amylase, C-terminal all-beta domain 0.1183 PF02155 Glucocorticoid receptor 0.0883 PF00128 Alpha amylase, catalytic domain 0.0858 PF03414 Glycosyltransferase family 6 0.0780 PF00079 Serpin (serine protease inhibitor), 0.0711 PF01048 Phosphorylase superfamily 0.0616 PF03953 Tubulin C-terminal domain 0.0616 PF00091 Tubulin/FtsZ family, GTPase domain 0.0542 PF02223 Thymidylate kinase 0.0446 PF01735 Lysophospholipase catalytic domain 0.0404 PF00303 Thymidylate synthase 0.0350 PF00106 short chain dehydrogenase 0.0289 PF00059 Lectin C-type domain 0.0283 PF00167 Fibroblast growth factor 0.0248 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0235 PF03770 Inositol polyphosphate kinase 0.0209 PF00005 ABC transporter 0.0200 PF01607 Chitin binding Peritrophin-A domain 0.0200 PF00704 Glycosyl hydrolases family 18 0.0182 PF01467 Cytidylyltransferase 0.0152 PF00664 ABC transporter transmembrane region 0.0152 PF00084 Sushi domain (SCR repeat), 0.0149 PF02267 ADP-ribosyl cyclase 0.0145 PF00171 Aldehyde dehydrogenase family 0.0139 PF00349 Hexokinase 0.0139 PF03727 Hexokinase 0.0135 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0135 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0132 PF07654 Immunoglobulin C1-set domain 0.0126 PF00976 Corticotropin ACTH domain 0.0126 PF08035 Opioids neuropeptide 0.0126 PF08384 Pro-opiomelanocortin, N-terminal region 0.0125 PF01370 NAD dependent epimerase/dehydratase family 0.0123 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.0104 PF01532 Glycosyl hydrolase family 47 0.0088 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0088 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0088 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0072 PF08240 Alcohol dehydrogenase GroES-like domain 0.0047 PF00248 Aldo/keto reductase family 0.0043 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0040 PF00107 Zinc-binding dehydrogenase 0.0038 PF00143 Interferon alpha/beta domain 0.0037 PF01687 Riboflavin kinase 0.0036 PF00071 Ras family 0.0025 PF01842 ACT domain 0.0024 PF01122 Eukaryotic cobalamin-binding protein 0.0024 PF01230 HIT domain 0.0020 PF00571 CBS domain 0.0015 PF03360 Glycosyltransferase family 43 0.0006 PF01055 Glycosyl hydrolases family 31 0.0006 PF00088 Trefoil (P-type), domain 0.0001 PF00229 TNF(Tumour Necrosis Factor), family SUB392 N(~C)(~C)(~C) 0.1429 PF00001 7 transmembrane receptor (rhodopsin family), 0.0375 PF03073 TspO/MBR family 0.0245 PF00209 Sodium:neurotransmitter symporter family 0.0242 PF01401 Angiotensin-converting enzyme 0.0238 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0235 PF06512 Sodium ion transport-associated 0.0226 PF00005 ABC transporter 0.0197 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0193 PF00664 ABC transporter transmembrane region 0.0150 PF00989 PAS fold 0.0139 PF01593 Flavin containing amine oxidoreductase 0.0136 PF00520 Ion transport protein 0.0133 PF00069 Protein kinase domain 0.0126 PF00186 Dihydrofolate reductase 0.0123 PF00027 Cyclic nucleotide-binding domain 0.0123 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0123 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0100 PF01048 Phosphorylase superfamily 0.0076 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0059 PF08070 DTHCT (NUC029), region 0.0059 PF00204 DNA gyrase B 0.0059 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0057 PF03953 Tubulin C-terminal domain 0.0057 PF00091 Tubulin/FtsZ family, GTPase domain 0.0043 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0043 PF02180 Bcl-2 homology region 4 0.0039 PF01061 ABC-2 type transporter 0.0038 PF08983 Domain of unknown function (DUF1856), 0.0037 PF00017 SH2 domain 0.0016 PF08491 Squalene epoxidase 0.0016 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0016 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0014 PF08919 F-actin binding 0.0013 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0010 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0010 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0010 PF00018 SH3 domain 0.0006 PF01467 Cytidylyltransferase 0.0006 PF02223 Thymidylate kinase 0.0003 PF00962 Adenosine/AMP deaminase 0.0002 PF01126 Heme oxygenase 0.0001 PF09396 Thrombin light chain SUB457 P(-O)(=O) 0.1420 PF02223 Thymidylate kinase 0.1139 PF00348 Polyprenyl synthetase 0.0767 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0751 PF08240 Alcohol dehydrogenase GroES-like domain 0.0686 PF03770 Inositol polyphosphate kinase 0.0646 PF00107 Zinc-binding dehydrogenase 0.0607 PF00106 short chain dehydrogenase 0.0586 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0569 PF02267 ADP-ribosyl cyclase 0.0564 PF00102 Protein-tyrosine phosphatase 0.0489 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0489 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0487 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0487 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0487 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0469 PF01370 NAD dependent epimerase/dehydratase family 0.0416 PF00248 Aldo/keto reductase family 0.0393 PF00171 Aldehyde dehydrogenase family 0.0377 PF01467 Cytidylyltransferase 0.0302 PF00478 IMP dehydrogenase / GMP reductase domain 0.0286 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0286 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0284 PF01122 Eukaryotic cobalamin-binding protein 0.0219 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0210 PF02310 B12 binding domain 0.0199 PF01923 Cobalamin adenosyltransferase 0.0199 PF01642 Methylmalonyl-CoA mutase 0.0199 PF03308 ArgK protein 0.0178 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0166 PF00571 CBS domain 0.0141 PF00169 PH domain 0.0115 PF08674 Acetylcholinesterase tetramerisation domain 0.0111 PF00225 Kinesin motor domain 0.0106 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0102 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0102 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0095 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0095 PF00155 Aminotransferase class I and II 0.0095 PF02607 B12 binding domain 0.0095 PF00809 Pterin binding enzyme 0.0093 PF00431 CUB domain 0.0091 PF03360 Glycosyltransferase family 43 0.0091 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0090 PF00266 Aminotransferase class-V 0.0087 PF00258 Flavodoxin 0.0087 PF00667 FAD binding domain 0.0086 PF08676 MutL C terminal dimerisation domain 0.0086 PF01119 DNA mismatch repair protein, C-terminal domain 0.0086 PF00175 Oxidoreductase NAD-binding domain 0.0086 PF00501 AMP-binding enzyme 0.0086 PF12423 Kinesin protein 1B 0.0086 PF12473 Kinesin protein 0.0086 PF00498 FHA domain 0.0085 PF00069 Protein kinase domain 0.0084 PF02036 SCP-2 sterol transfer family 0.0084 PF01575 MaoC like domain 0.0083 PF00390 Malic enzyme, N-terminal domain 0.0083 PF01652 Eukaryotic initiation factor 4E 0.0083 PF03949 Malic enzyme, NAD binding domain 0.0082 PF00970 Oxidoreductase FAD-binding domain 0.0073 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0073 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0071 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0071 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0066 PF00464 Serine hydroxymethyltransferase 0.0065 PF00400 WD domain, G-beta repeat 0.0065 PF00931 NB-ARC domain 0.0062 PF02233 NAD(P), transhydrogenase beta subunit 0.0061 PF07645 Calcium-binding EGF domain 0.0059 PF00291 Pyridoxal-phosphate dependent enzyme 0.0057 PF00202 Aminotransferase class-III 0.0054 PF01063 Aminotransferase class IV 0.0052 PF00343 Carbohydrate phosphorylase 0.0051 PF00018 SH3 domain 0.0049 PF02574 Homocysteine S-methyltransferase 0.0048 PF00071 Ras family 0.0044 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0044 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0040 PF00074 Pancreatic ribonuclease 0.0037 PF00294 pfkB family carbohydrate kinase 0.0030 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0030 PF00702 haloacid dehalogenase-like hydrolase 0.0026 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0026 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0023 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0023 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0022 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0022 PF01212 Beta-eliminating lyase 0.0022 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0022 PF01168 Alanine racemase, N-terminal domain 0.0022 PF03476 MOSC N-terminal beta barrel domain 0.0022 PF01202 Shikimate kinase 0.0022 PF03473 MOSC domain 0.0022 PF02347 Glycine cleavage system P-protein 0.0021 PF07706 Aminotransferase ubiquitination site 0.0021 PF02971 Formiminotransferase domain 0.0021 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0021 PF04961 Formiminotransferase-cyclodeaminase 0.0018 PF01126 Heme oxygenase 0.0016 PF01596 O-methyltransferase 0.0011 PF00349 Hexokinase 0.0011 PF03727 Hexokinase 0.0007 PF01687 Riboflavin kinase 0.0007 PF01268 Formate--tetrahydrofolate ligase 0.0007 PF00058 Low-density lipoprotein receptor repeat class B 0.0007 PF00057 Low-density lipoprotein receptor domain class A 0.0007 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0007 PF00676 Dehydrogenase E1 component 0.0007 PF02525 Flavodoxin-like fold 0.0006 PF00017 SH2 domain 0.0006 PF00186 Dihydrofolate reductase 0.0005 PF01230 HIT domain 0.0005 PF02394 Interleukin-1 propeptide 0.0005 PF00378 Enoyl-CoA hydratase/isomerase family 0.0005 PF00340 Interleukin-1 / 18 0.0005 PF00342 Phosphoglucose isomerase 0.0004 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0004 PF00576 HIUase/Transthyretin family 0.0004 PF00689 Cation transporting ATPase, C-terminus 0.0004 PF01833 IPT/TIG domain 0.0004 PF01403 Sema domain 0.0004 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0004 PF01588 Putative tRNA binding domain 0.0004 PF01437 Plexin repeat 0.0004 PF00690 Cation transporter/ATPase, N-terminus 0.0004 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0004 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0004 PF05347 Complex 1 protein (LYR family), 0.0004 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0004 PF02779 Transketolase, pyrimidine binding domain 0.0003 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0003 PF01916 Deoxyhypusine synthase 0.0003 PF00122 E1-E2 ATPase 0.0003 PF00794 PI3-kinase family, ras-binding domain 0.0003 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0002 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0002 PF09326 Domain of unknown function (DUF1982), 0.0002 PF08070 DTHCT (NUC029), region 0.0002 PF04116 Fatty acid hydroxylase superfamily 0.0002 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0002 PF04800 ETC complex I subunit conserved region 0.0002 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0002 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0002 PF06212 GRIM-19 protein 0.0002 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0002 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0002 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0002 PF10531 SLBB domain 0.0002 PF02817 e3 binding domain 0.0002 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0002 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0002 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0002 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0002 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0002 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0002 PF01808 AICARFT/IMPCHase bienzyme 0.0002 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0002 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0002 PF00204 DNA gyrase B 0.0002 PF08040 MNLL subunit 0.0002 PF09166 Biliverdin reductase, catalytic 0.0002 PF00384 Molybdopterin oxidoreductase 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0002 PF04716 ETC complex I subunit conserved region 0.0002 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0002 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0002 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0002 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0002 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0002 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0002 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0002 PF10276 Zinc-finger domain 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0002 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0002 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0002 PF02466 Tim17/Tim22/Tim23 family 0.0002 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0002 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF00170 bZIP transcription factor 0.0001 PF02173 pKID domain 0.0001 PF00042 Globin 0.0001 PF02780 Transketolase, C-terminal domain 0.0001 PF00962 Adenosine/AMP deaminase 0.0001 PF00406 Adenylate kinase 0.0001 PF01064 Activin types I and II receptor domain 0.0001 PF08515 Transforming growth factor beta type I GS-motif 0.0001 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0001 PF00149 Calcineurin-like phosphoesterase 0.0001 PF03435 Saccharopine dehydrogenase SUB426 P=O 0.1420 PF02223 Thymidylate kinase 0.1139 PF00348 Polyprenyl synthetase 0.0767 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0751 PF08240 Alcohol dehydrogenase GroES-like domain 0.0686 PF03770 Inositol polyphosphate kinase 0.0646 PF00107 Zinc-binding dehydrogenase 0.0607 PF00106 short chain dehydrogenase 0.0586 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0569 PF02267 ADP-ribosyl cyclase 0.0564 PF00102 Protein-tyrosine phosphatase 0.0489 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0489 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0487 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0487 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0487 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0469 PF01370 NAD dependent epimerase/dehydratase family 0.0416 PF00248 Aldo/keto reductase family 0.0393 PF00171 Aldehyde dehydrogenase family 0.0377 PF01467 Cytidylyltransferase 0.0302 PF00478 IMP dehydrogenase / GMP reductase domain 0.0286 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0286 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0284 PF01122 Eukaryotic cobalamin-binding protein 0.0219 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0210 PF02310 B12 binding domain 0.0199 PF01923 Cobalamin adenosyltransferase 0.0199 PF01642 Methylmalonyl-CoA mutase 0.0199 PF03308 ArgK protein 0.0178 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0166 PF00571 CBS domain 0.0141 PF00169 PH domain 0.0115 PF08674 Acetylcholinesterase tetramerisation domain 0.0111 PF00225 Kinesin motor domain 0.0106 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0102 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0102 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0095 PF02607 B12 binding domain 0.0095 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0095 PF00809 Pterin binding enzyme 0.0095 PF00155 Aminotransferase class I and II 0.0093 PF00431 CUB domain 0.0091 PF03360 Glycosyltransferase family 43 0.0091 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0090 PF00266 Aminotransferase class-V 0.0087 PF00258 Flavodoxin 0.0087 PF00667 FAD binding domain 0.0086 PF00501 AMP-binding enzyme 0.0086 PF12423 Kinesin protein 1B 0.0086 PF00498 FHA domain 0.0086 PF12473 Kinesin protein 0.0086 PF01119 DNA mismatch repair protein, C-terminal domain 0.0086 PF08676 MutL C terminal dimerisation domain 0.0086 PF00175 Oxidoreductase NAD-binding domain 0.0085 PF00069 Protein kinase domain 0.0084 PF01575 MaoC like domain 0.0084 PF02036 SCP-2 sterol transfer family 0.0083 PF00390 Malic enzyme, N-terminal domain 0.0083 PF01652 Eukaryotic initiation factor 4E 0.0083 PF03949 Malic enzyme, NAD binding domain 0.0082 PF00970 Oxidoreductase FAD-binding domain 0.0073 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0073 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0071 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0071 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0066 PF00464 Serine hydroxymethyltransferase 0.0065 PF00931 NB-ARC domain 0.0065 PF00400 WD domain, G-beta repeat 0.0062 PF02233 NAD(P), transhydrogenase beta subunit 0.0061 PF07645 Calcium-binding EGF domain 0.0059 PF00291 Pyridoxal-phosphate dependent enzyme 0.0057 PF00202 Aminotransferase class-III 0.0054 PF01063 Aminotransferase class IV 0.0052 PF00343 Carbohydrate phosphorylase 0.0051 PF00018 SH3 domain 0.0049 PF02574 Homocysteine S-methyltransferase 0.0048 PF00071 Ras family 0.0044 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0044 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0040 PF00074 Pancreatic ribonuclease 0.0037 PF00294 pfkB family carbohydrate kinase 0.0030 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0030 PF00702 haloacid dehalogenase-like hydrolase 0.0026 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0026 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0023 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0023 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0022 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0022 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0022 PF02347 Glycine cleavage system P-protein 0.0022 PF03476 MOSC N-terminal beta barrel domain 0.0022 PF01168 Alanine racemase, N-terminal domain 0.0022 PF03473 MOSC domain 0.0022 PF01202 Shikimate kinase 0.0022 PF01212 Beta-eliminating lyase 0.0021 PF02971 Formiminotransferase domain 0.0021 PF04961 Formiminotransferase-cyclodeaminase 0.0021 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0021 PF07706 Aminotransferase ubiquitination site 0.0018 PF01126 Heme oxygenase 0.0016 PF01596 O-methyltransferase 0.0011 PF03727 Hexokinase 0.0011 PF00349 Hexokinase 0.0007 PF00057 Low-density lipoprotein receptor domain class A 0.0007 PF00058 Low-density lipoprotein receptor repeat class B 0.0007 PF01687 Riboflavin kinase 0.0007 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0007 PF00676 Dehydrogenase E1 component 0.0007 PF02525 Flavodoxin-like fold 0.0007 PF01268 Formate--tetrahydrofolate ligase 0.0006 PF00017 SH2 domain 0.0006 PF00186 Dihydrofolate reductase 0.0005 PF01230 HIT domain 0.0005 PF00340 Interleukin-1 / 18 0.0005 PF00378 Enoyl-CoA hydratase/isomerase family 0.0005 PF00342 Phosphoglucose isomerase 0.0005 PF02394 Interleukin-1 propeptide 0.0004 PF00690 Cation transporter/ATPase, N-terminus 0.0004 PF00689 Cation transporting ATPase, C-terminus 0.0004 PF01588 Putative tRNA binding domain 0.0004 PF02779 Transketolase, pyrimidine binding domain 0.0004 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0004 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0004 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0004 PF00576 HIUase/Transthyretin family 0.0004 PF01403 Sema domain 0.0004 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0004 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0004 PF01833 IPT/TIG domain 0.0004 PF01437 Plexin repeat 0.0004 PF05347 Complex 1 protein (LYR family), 0.0003 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0003 PF00122 E1-E2 ATPase 0.0003 PF01916 Deoxyhypusine synthase 0.0003 PF00794 PI3-kinase family, ras-binding domain 0.0003 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF09326 Domain of unknown function (DUF1982), 0.0002 PF08040 MNLL subunit 0.0002 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0002 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0002 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0002 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0002 PF08070 DTHCT (NUC029), region 0.0002 PF04116 Fatty acid hydroxylase superfamily 0.0002 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF00204 DNA gyrase B 0.0002 PF10531 SLBB domain 0.0002 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0002 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0002 PF04716 ETC complex I subunit conserved region 0.0002 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0002 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0002 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0002 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0002 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0002 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0002 PF06212 GRIM-19 protein 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0002 PF10276 Zinc-finger domain 0.0002 PF02817 e3 binding domain 0.0002 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0002 PF09166 Biliverdin reductase, catalytic 0.0002 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0002 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0002 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0002 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0002 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0002 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0002 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0002 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0002 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0002 PF00384 Molybdopterin oxidoreductase 0.0002 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0002 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0002 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0002 PF04800 ETC complex I subunit conserved region 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0002 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0002 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0002 PF01808 AICARFT/IMPCHase bienzyme 0.0002 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF08515 Transforming growth factor beta type I GS-motif 0.0001 PF01064 Activin types I and II receptor domain 0.0001 PF00149 Calcineurin-like phosphoesterase 0.0001 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0001 PF00042 Globin 0.0001 PF02780 Transketolase, C-terminal domain 0.0001 PF00170 bZIP transcription factor 0.0001 PF03435 Saccharopine dehydrogenase 0.0001 PF02173 pKID domain 0.0001 PF00406 Adenylate kinase 0.0001 PF00962 Adenosine/AMP deaminase SUB861 CC1C(C)CCC1 0.1418 PF02159 Oestrogen receptor 0.1203 PF02155 Glucocorticoid receptor 0.1200 PF00191 Annexin 0.1046 PF00105 Zinc finger, C4 type (two domains), 0.1044 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1027 PF02161 Progesterone receptor 0.0785 PF02166 Androgen receptor 0.0562 PF01735 Lysophospholipase catalytic domain 0.0467 PF00079 Serpin (serine protease inhibitor), 0.0224 PF00168 C2 domain 0.0179 PF12497 Estrogen receptor beta 0.0146 PF08035 Opioids neuropeptide 0.0146 PF00976 Corticotropin ACTH domain 0.0146 PF08384 Pro-opiomelanocortin, N-terminal region 0.0117 PF00689 Cation transporting ATPase, C-terminus 0.0117 PF00690 Cation transporter/ATPase, N-terminus 0.0104 PF00122 E1-E2 ATPase 0.0088 PF00702 haloacid dehalogenase-like hydrolase 0.0078 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0078 PF07648 Kazal-type serine protease inhibitor domain 0.0078 PF00554 Rel homology domain (RHD), 0.0076 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0076 PF00031 Cystatin domain 0.0072 PF00212 Atrial natriuretic peptide 0.0065 PF08377 MAP2/Tau projection domain 0.0065 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0057 PF00067 Cytochrome P450 0.0054 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0052 PF01607 Chitin binding Peritrophin-A domain 0.0052 PF00704 Glycosyl hydrolases family 18 0.0050 PF00039 Fibronectin type I domain 0.0045 PF02898 Nitric oxide synthase, oxygenase domain 0.0040 PF00106 short chain dehydrogenase 0.0040 PF00531 Death domain 0.0039 PF00762 Ferrochelatase 0.0034 PF00654 Voltage gated chloride channel 0.0034 PF09164 Vitamin D binding protein, domain III 0.0032 PF02180 Bcl-2 homology region 4 0.0032 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0027 PF00258 Flavodoxin 0.0027 PF00305 Lipoxygenase 0.0027 PF00667 FAD binding domain 0.0023 PF02038 ATP1G1/PLM/MAT8 family 0.0023 PF00884 Sulfatase 0.0022 PF00175 Oxidoreductase NAD-binding domain 0.0021 PF07884 Vitamin K epoxide reductase family 0.0021 PF00432 Prenyltransferase and squalene oxidase repeat 0.0014 PF00023 Ankyrin repeat 0.0010 PF00341 Platelet-derived growth factor (PDGF), 0.0010 PF01477 PLAT/LH2 domain 0.0009 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0009 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0009 PF04756 OST3 / OST6 family 0.0009 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0009 PF02210 Laminin G domain 0.0009 PF00377 Prion/Doppel alpha-helical domain 0.0009 PF00969 Class II histocompatibility antigen, beta domain 0.0008 PF01593 Flavin containing amine oxidoreductase 0.0005 PF00020 TNFR/NGFR cysteine-rich region 0.0005 PF01429 Methyl-CpG binding domain 0.0005 PF00688 TGF-beta propeptide 0.0005 PF00019 Transforming growth factor beta like domain 0.0005 PF05193 Peptidase M16 inactive domain 0.0005 PF00675 Insulinase (Peptidase family M16), 0.0004 PF00340 Interleukin-1 / 18 0.0004 PF00714 Interferon gamma 0.0004 PF02394 Interleukin-1 propeptide 0.0002 PF00656 Caspase domain 0.0002 PF05649 Peptidase family M13 0.0002 PF01391 Collagen triple helix repeat (20 copies), 0.0002 PF01431 Peptidase family M13 SUB315 O-P 0.1411 PF02223 Thymidylate kinase 0.1132 PF00348 Polyprenyl synthetase 0.0762 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0746 PF08240 Alcohol dehydrogenase GroES-like domain 0.0682 PF03770 Inositol polyphosphate kinase 0.0641 PF00107 Zinc-binding dehydrogenase 0.0603 PF00106 short chain dehydrogenase 0.0582 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0565 PF02267 ADP-ribosyl cyclase 0.0561 PF00102 Protein-tyrosine phosphatase 0.0486 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0486 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0484 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0484 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0484 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0466 PF01370 NAD dependent epimerase/dehydratase family 0.0413 PF00248 Aldo/keto reductase family 0.0391 PF00171 Aldehyde dehydrogenase family 0.0375 PF01467 Cytidylyltransferase 0.0300 PF00478 IMP dehydrogenase / GMP reductase domain 0.0284 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0284 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0281 PF01122 Eukaryotic cobalamin-binding protein 0.0217 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0208 PF02310 B12 binding domain 0.0197 PF01642 Methylmalonyl-CoA mutase 0.0197 PF01923 Cobalamin adenosyltransferase 0.0197 PF03308 ArgK protein 0.0177 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0165 PF00571 CBS domain 0.0140 PF00169 PH domain 0.0114 PF08674 Acetylcholinesterase tetramerisation domain 0.0110 PF00225 Kinesin motor domain 0.0105 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0101 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0101 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0094 PF00809 Pterin binding enzyme 0.0094 PF02607 B12 binding domain 0.0094 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0093 PF00155 Aminotransferase class I and II 0.0092 PF00431 CUB domain 0.0091 PF03360 Glycosyltransferase family 43 0.0089 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0088 PF00266 Aminotransferase class-V 0.0086 PF00258 Flavodoxin 0.0086 PF08676 MutL C terminal dimerisation domain 0.0086 PF00667 FAD binding domain 0.0086 PF12473 Kinesin protein 0.0086 PF01119 DNA mismatch repair protein, C-terminal domain 0.0086 PF12423 Kinesin protein 1B 0.0086 PF00498 FHA domain 0.0085 PF00175 Oxidoreductase NAD-binding domain 0.0085 PF00501 AMP-binding enzyme 0.0084 PF00069 Protein kinase domain 0.0083 PF00390 Malic enzyme, N-terminal domain 0.0083 PF02036 SCP-2 sterol transfer family 0.0083 PF01575 MaoC like domain 0.0083 PF03949 Malic enzyme, NAD binding domain 0.0082 PF01652 Eukaryotic initiation factor 4E 0.0082 PF00970 Oxidoreductase FAD-binding domain 0.0072 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0072 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0071 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0071 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0065 PF00931 NB-ARC domain 0.0065 PF00464 Serine hydroxymethyltransferase 0.0065 PF00400 WD domain, G-beta repeat 0.0061 PF02233 NAD(P), transhydrogenase beta subunit 0.0060 PF07645 Calcium-binding EGF domain 0.0058 PF00291 Pyridoxal-phosphate dependent enzyme 0.0055 PF00202 Aminotransferase class-III 0.0053 PF01063 Aminotransferase class IV 0.0051 PF00018 SH3 domain 0.0051 PF00343 Carbohydrate phosphorylase 0.0048 PF02574 Homocysteine S-methyltransferase 0.0047 PF00071 Ras family 0.0043 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0043 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0040 PF00074 Pancreatic ribonuclease 0.0037 PF00294 pfkB family carbohydrate kinase 0.0029 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0029 PF00702 haloacid dehalogenase-like hydrolase 0.0026 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0026 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0023 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0023 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0021 PF01212 Beta-eliminating lyase 0.0021 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0021 PF04961 Formiminotransferase-cyclodeaminase 0.0021 PF03476 MOSC N-terminal beta barrel domain 0.0021 PF03473 MOSC domain 0.0021 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0021 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0021 PF02347 Glycine cleavage system P-protein 0.0021 PF02971 Formiminotransferase domain 0.0021 PF01168 Alanine racemase, N-terminal domain 0.0021 PF01202 Shikimate kinase 0.0020 PF07706 Aminotransferase ubiquitination site 0.0018 PF01126 Heme oxygenase 0.0015 PF01596 O-methyltransferase 0.0011 PF03727 Hexokinase 0.0011 PF00349 Hexokinase 0.0007 PF00057 Low-density lipoprotein receptor domain class A 0.0007 PF00058 Low-density lipoprotein receptor repeat class B 0.0007 PF00676 Dehydrogenase E1 component 0.0007 PF01268 Formate--tetrahydrofolate ligase 0.0007 PF01687 Riboflavin kinase 0.0007 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0006 PF00186 Dihydrofolate reductase 0.0006 PF00017 SH2 domain 0.0006 PF02525 Flavodoxin-like fold 0.0005 PF00378 Enoyl-CoA hydratase/isomerase family 0.0005 PF02394 Interleukin-1 propeptide 0.0005 PF00340 Interleukin-1 / 18 0.0005 PF00342 Phosphoglucose isomerase 0.0005 PF01230 HIT domain 0.0004 PF00689 Cation transporting ATPase, C-terminus 0.0004 PF01588 Putative tRNA binding domain 0.0004 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0004 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0004 PF02779 Transketolase, pyrimidine binding domain 0.0004 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0004 PF00690 Cation transporter/ATPase, N-terminus 0.0004 PF01403 Sema domain 0.0004 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0004 PF05347 Complex 1 protein (LYR family), 0.0004 PF01437 Plexin repeat 0.0004 PF01833 IPT/TIG domain 0.0003 PF00792 Phosphoinositide 3-kinase C2 0.0003 PF00794 PI3-kinase family, ras-binding domain 0.0003 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0003 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0003 PF01916 Deoxyhypusine synthase 0.0003 PF00122 E1-E2 ATPase 0.0003 PF00576 HIUase/Transthyretin family 0.0002 PF10531 SLBB domain 0.0002 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0002 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF02466 Tim17/Tim22/Tim23 family 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0002 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0002 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0002 PF04716 ETC complex I subunit conserved region 0.0002 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0002 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0002 PF04116 Fatty acid hydroxylase superfamily 0.0002 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0002 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0002 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0002 PF04800 ETC complex I subunit conserved region 0.0002 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0002 PF10276 Zinc-finger domain 0.0002 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0002 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0002 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0002 PF02817 e3 binding domain 0.0002 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0002 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0002 PF08070 DTHCT (NUC029), region 0.0002 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0002 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0002 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0002 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0002 PF09326 Domain of unknown function (DUF1982), 0.0002 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0002 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0002 PF00384 Molybdopterin oxidoreductase 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF01808 AICARFT/IMPCHase bienzyme 0.0002 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0002 PF00204 DNA gyrase B 0.0002 PF06212 GRIM-19 protein 0.0002 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0002 PF09166 Biliverdin reductase, catalytic 0.0002 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0002 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0002 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0002 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0002 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0002 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0002 PF08040 MNLL subunit 0.0001 PF00170 bZIP transcription factor 0.0001 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0001 PF00042 Globin 0.0001 PF03435 Saccharopine dehydrogenase 0.0001 PF00149 Calcineurin-like phosphoesterase 0.0001 PF08515 Transforming growth factor beta type I GS-motif 0.0001 PF02780 Transketolase, C-terminal domain 0.0001 PF02173 pKID domain 0.0001 PF01064 Activin types I and II receptor domain 0.0001 PF00406 Adenylate kinase 0.0001 PF00962 Adenosine/AMP deaminase SUB412 P(~O)(~O) 0.1411 PF02223 Thymidylate kinase 0.1132 PF00348 Polyprenyl synthetase 0.0762 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0746 PF08240 Alcohol dehydrogenase GroES-like domain 0.0682 PF03770 Inositol polyphosphate kinase 0.0641 PF00107 Zinc-binding dehydrogenase 0.0603 PF00106 short chain dehydrogenase 0.0582 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0565 PF02267 ADP-ribosyl cyclase 0.0561 PF00102 Protein-tyrosine phosphatase 0.0486 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0486 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0484 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0484 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0484 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0466 PF01370 NAD dependent epimerase/dehydratase family 0.0413 PF00248 Aldo/keto reductase family 0.0391 PF00171 Aldehyde dehydrogenase family 0.0375 PF01467 Cytidylyltransferase 0.0300 PF00478 IMP dehydrogenase / GMP reductase domain 0.0284 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0284 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0281 PF01122 Eukaryotic cobalamin-binding protein 0.0217 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0208 PF02310 B12 binding domain 0.0197 PF01642 Methylmalonyl-CoA mutase 0.0197 PF03308 ArgK protein 0.0197 PF01923 Cobalamin adenosyltransferase 0.0177 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0165 PF00571 CBS domain 0.0140 PF00169 PH domain 0.0114 PF08674 Acetylcholinesterase tetramerisation domain 0.0110 PF00225 Kinesin motor domain 0.0105 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0101 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0101 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0094 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0094 PF02607 B12 binding domain 0.0094 PF00809 Pterin binding enzyme 0.0093 PF00155 Aminotransferase class I and II 0.0092 PF00431 CUB domain 0.0091 PF03360 Glycosyltransferase family 43 0.0089 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0088 PF00266 Aminotransferase class-V 0.0086 PF01119 DNA mismatch repair protein, C-terminal domain 0.0086 PF12473 Kinesin protein 0.0086 PF00258 Flavodoxin 0.0086 PF12423 Kinesin protein 1B 0.0086 PF08676 MutL C terminal dimerisation domain 0.0086 PF00667 FAD binding domain 0.0086 PF00498 FHA domain 0.0085 PF00501 AMP-binding enzyme 0.0085 PF00175 Oxidoreductase NAD-binding domain 0.0084 PF00069 Protein kinase domain 0.0083 PF03949 Malic enzyme, NAD binding domain 0.0083 PF02036 SCP-2 sterol transfer family 0.0083 PF01575 MaoC like domain 0.0083 PF00390 Malic enzyme, N-terminal domain 0.0082 PF00970 Oxidoreductase FAD-binding domain 0.0082 PF01652 Eukaryotic initiation factor 4E 0.0072 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0072 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0071 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0071 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0065 PF00464 Serine hydroxymethyltransferase 0.0065 PF00931 NB-ARC domain 0.0065 PF00400 WD domain, G-beta repeat 0.0061 PF02233 NAD(P), transhydrogenase beta subunit 0.0060 PF07645 Calcium-binding EGF domain 0.0058 PF00291 Pyridoxal-phosphate dependent enzyme 0.0055 PF00202 Aminotransferase class-III 0.0053 PF01063 Aminotransferase class IV 0.0051 PF00343 Carbohydrate phosphorylase 0.0051 PF00018 SH3 domain 0.0048 PF02574 Homocysteine S-methyltransferase 0.0047 PF00071 Ras family 0.0043 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0043 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0040 PF00074 Pancreatic ribonuclease 0.0037 PF00294 pfkB family carbohydrate kinase 0.0029 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0029 PF00702 haloacid dehalogenase-like hydrolase 0.0026 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0026 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0023 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0023 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0021 PF01212 Beta-eliminating lyase 0.0021 PF02347 Glycine cleavage system P-protein 0.0021 PF02971 Formiminotransferase domain 0.0021 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0021 PF03473 MOSC domain 0.0021 PF03476 MOSC N-terminal beta barrel domain 0.0021 PF01168 Alanine racemase, N-terminal domain 0.0021 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0021 PF04961 Formiminotransferase-cyclodeaminase 0.0021 PF01202 Shikimate kinase 0.0021 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0020 PF07706 Aminotransferase ubiquitination site 0.0018 PF01126 Heme oxygenase 0.0015 PF01596 O-methyltransferase 0.0011 PF00349 Hexokinase 0.0011 PF03727 Hexokinase 0.0007 PF01268 Formate--tetrahydrofolate ligase 0.0007 PF01687 Riboflavin kinase 0.0007 PF00676 Dehydrogenase E1 component 0.0007 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0007 PF00058 Low-density lipoprotein receptor repeat class B 0.0007 PF00057 Low-density lipoprotein receptor domain class A 0.0006 PF02525 Flavodoxin-like fold 0.0006 PF00017 SH2 domain 0.0006 PF00186 Dihydrofolate reductase 0.0005 PF00340 Interleukin-1 / 18 0.0005 PF00342 Phosphoglucose isomerase 0.0005 PF01230 HIT domain 0.0005 PF02394 Interleukin-1 propeptide 0.0005 PF00378 Enoyl-CoA hydratase/isomerase family 0.0004 PF02779 Transketolase, pyrimidine binding domain 0.0004 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0004 PF01437 Plexin repeat 0.0004 PF00689 Cation transporting ATPase, C-terminus 0.0004 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0004 PF05347 Complex 1 protein (LYR family), 0.0004 PF01588 Putative tRNA binding domain 0.0004 PF01833 IPT/TIG domain 0.0004 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0004 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0004 PF01403 Sema domain 0.0004 PF00690 Cation transporter/ATPase, N-terminus 0.0003 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0003 PF00794 PI3-kinase family, ras-binding domain 0.0003 PF00792 Phosphoinositide 3-kinase C2 0.0003 PF00576 HIUase/Transthyretin family 0.0003 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0003 PF00122 E1-E2 ATPase 0.0003 PF01916 Deoxyhypusine synthase 0.0002 PF06212 GRIM-19 protein 0.0002 PF02466 Tim17/Tim22/Tim23 family 0.0002 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0002 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0002 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0002 PF10531 SLBB domain 0.0002 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0002 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0002 PF10276 Zinc-finger domain 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0002 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0002 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0002 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0002 PF00384 Molybdopterin oxidoreductase 0.0002 PF01808 AICARFT/IMPCHase bienzyme 0.0002 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0002 PF09326 Domain of unknown function (DUF1982), 0.0002 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0002 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0002 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0002 PF04800 ETC complex I subunit conserved region 0.0002 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0002 PF04116 Fatty acid hydroxylase superfamily 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0002 PF04716 ETC complex I subunit conserved region 0.0002 PF08070 DTHCT (NUC029), region 0.0002 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0002 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0002 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0002 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0002 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0002 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0002 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0002 PF08040 MNLL subunit 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0002 PF02817 e3 binding domain 0.0002 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0002 PF09166 Biliverdin reductase, catalytic 0.0002 PF00204 DNA gyrase B 0.0002 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0002 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0002 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0002 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0002 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0002 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF00042 Globin 0.0001 PF00962 Adenosine/AMP deaminase 0.0001 PF02780 Transketolase, C-terminal domain 0.0001 PF00406 Adenylate kinase 0.0001 PF01064 Activin types I and II receptor domain 0.0001 PF02173 pKID domain 0.0001 PF00170 bZIP transcription factor 0.0001 PF08515 Transforming growth factor beta type I GS-motif 0.0001 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0001 PF00149 Calcineurin-like phosphoesterase 0.0001 PF03435 Saccharopine dehydrogenase SUB705 O=C-C-C-C-C-C-C 0.1405 PF03098 Animal haem peroxidase 0.1402 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1402 PF00204 DNA gyrase B 0.1402 PF08070 DTHCT (NUC029), region 0.0797 PF00191 Annexin 0.0700 PF02155 Glucocorticoid receptor 0.0656 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0592 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0587 PF00105 Zinc finger, C4 type (two domains), 0.0577 PF00273 Serum albumin family 0.0501 PF00102 Protein-tyrosine phosphatase 0.0395 PF07884 Vitamin K epoxide reductase family 0.0264 PF01735 Lysophospholipase catalytic domain 0.0247 PF00005 ABC transporter 0.0235 PF06512 Sodium ion transport-associated 0.0222 PF02161 Progesterone receptor 0.0197 PF02525 Flavodoxin-like fold 0.0187 PF00576 HIUase/Transthyretin family 0.0183 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0181 PF00079 Serpin (serine protease inhibitor), 0.0179 PF01268 Formate--tetrahydrofolate ligase 0.0175 PF00464 Serine hydroxymethyltransferase 0.0173 PF02166 Androgen receptor 0.0171 PF00664 ABC transporter transmembrane region 0.0163 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0163 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0162 PF09396 Thrombin light chain 0.0140 PF00089 Trypsin 0.0140 PF00051 Kringle domain 0.0125 PF00554 Rel homology domain (RHD), 0.0118 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0118 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0118 PF08063 PADR1 (NUC008), domain 0.0118 PF00533 BRCA1 C Terminus (BRCT), domain 0.0118 PF05406 WGR domain 0.0106 PF01061 ABC-2 type transporter 0.0104 PF08403 Amino acid permease N-terminal 0.0102 PF00551 Formyl transferase 0.0095 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0092 PF11825 Protein of unknown function (DUF3345), 0.0088 PF00017 SH2 domain 0.0080 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0080 PF01571 Aminomethyltransferase folate-binding domain 0.0054 PF00018 SH3 domain 0.0053 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0053 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0053 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0046 PF02219 Methylenetetrahydrofolate reductase 0.0044 PF00531 Death domain 0.0041 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0030 PF00229 TNF(Tumour Necrosis Factor), family 0.0029 PF00183 Hsp90 protein 0.0021 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0017 PF01467 Cytidylyltransferase 0.0013 PF02911 Formyl transferase, C-terminal domain 0.0013 PF00343 Carbohydrate phosphorylase 0.0013 PF03024 Folate receptor family 0.0009 PF00248 Aldo/keto reductase family 0.0003 PF01180 Dihydroorotate dehydrogenase 0.0001 PF01596 O-methyltransferase SUB214 >= 1 any ring size 7 0.1401 PF03073 TspO/MBR family 0.1266 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1266 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0139 PF00343 Carbohydrate phosphorylase 0.0127 PF08403 Amino acid permease N-terminal 0.0121 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0114 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0114 PF02254 TrkA-N domain 0.0112 PF00989 PAS fold 0.0093 PF02196 Raf-like Ras-binding domain 0.0091 PF00194 Eukaryotic-type carbonic anhydrase 0.0088 PF00027 Cyclic nucleotide-binding domain 0.0085 PF00209 Sodium:neurotransmitter symporter family 0.0079 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0078 PF00001 7 transmembrane receptor (rhodopsin family), 0.0077 PF00018 SH3 domain 0.0076 PF00186 Dihydrofolate reductase 0.0071 PF00520 Ion transport protein 0.0067 PF00017 SH2 domain 0.0062 PF01007 Inward rectifier potassium channel 0.0062 PF06512 Sodium ion transport-associated 0.0055 PF08919 F-actin binding 0.0044 PF00243 Nerve growth factor family 0.0044 PF00612 IQ calmodulin-binding motif 0.0042 PF00664 ABC transporter transmembrane region 0.0041 PF00690 Cation transporter/ATPase, N-terminus 0.0041 PF00689 Cation transporting ATPase, C-terminus 0.0040 PF00536 SAM domain (Sterile alpha motif), 0.0040 PF01404 Ephrin receptor ligand binding domain 0.0039 PF00005 ABC transporter 0.0037 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0034 PF00122 E1-E2 ATPase 0.0030 PF00324 Amino acid permease 0.0027 PF02864 STAT protein, DNA binding domain 0.0027 PF02865 STAT protein, protein interaction domain 0.0027 PF01017 STAT protein, all-alpha domain 0.0024 PF01234 NNMT/PNMT/TEMT family 0.0023 PF00702 haloacid dehalogenase-like hydrolase 0.0022 PF00069 Protein kinase domain 0.0021 PF00191 Annexin 0.0011 PF02743 Cache domain 0.0011 PF08399 VWA N-terminal 0.0011 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0011 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0007 PF02888 Calmodulin binding domain 0.0007 PF03530 Calcium-activated SK potassium channel 0.0007 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0007 PF07686 Immunoglobulin V-set domain 0.0006 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0006 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0006 PF01734 Patatin-like phospholipase 0.0006 PF03630 Fumble 0.0006 PF02038 ATP1G1/PLM/MAT8 family 0.0006 PF02060 Slow voltage-gated potassium channel 0.0003 PF03520 KCNQ voltage-gated potassium channel 0.0003 PF00146 NADH dehydrogenase 0.0002 PF00858 Amiloride-sensitive sodium channel 0.0001 PF01030 Receptor L domain 0.0001 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0001 PF00757 Furin-like cysteine rich region 0.0001 PF08912 Rho Binding 0.0001 PF00631 GGL domain 0.0001 PF01833 IPT/TIG domain 0.0001 PF02185 Hr1 repeat 0.0001 PF11956 Ankyrin-G binding motif of KCNQ2-3 0.0001 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 0.0001 PF01403 Sema domain 0.0001 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0001 PF00717 Peptidase S24-like 0.0001 PF01437 Plexin repeat 0.0001 PF02758 PAAD/DAPIN/Pyrin domain 0.0001 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0001 PF08377 MAP2/Tau projection domain SUB581 O=C-C-C-N 0.1401 PF00204 DNA gyrase B 0.1401 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1401 PF08070 DTHCT (NUC029), region 0.0696 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0530 PF00102 Protein-tyrosine phosphatase 0.0355 PF01048 Phosphorylase superfamily 0.0343 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0228 PF00303 Thymidylate synthase 0.0207 PF01590 GAF domain 0.0195 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0175 PF02525 Flavodoxin-like fold 0.0167 PF00576 HIUase/Transthyretin family 0.0166 PF08063 PADR1 (NUC008), domain 0.0166 PF00533 BRCA1 C Terminus (BRCT), domain 0.0166 PF05406 WGR domain 0.0166 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0166 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0161 PF00821 Phosphoenolpyruvate carboxykinase 0.0158 PF01467 Cytidylyltransferase 0.0156 PF01268 Formate--tetrahydrofolate ligase 0.0148 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0148 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0140 PF01808 AICARFT/IMPCHase bienzyme 0.0134 PF00107 Zinc-binding dehydrogenase 0.0133 PF00106 short chain dehydrogenase 0.0129 PF08240 Alcohol dehydrogenase GroES-like domain 0.0121 PF00248 Aldo/keto reductase family 0.0120 PF00071 Ras family 0.0110 PF00858 Amiloride-sensitive sodium channel 0.0106 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0098 PF00186 Dihydrofolate reductase 0.0096 PF01652 Eukaryotic initiation factor 4E 0.0093 PF02223 Thymidylate kinase 0.0089 PF02142 MGS-like domain 0.0088 PF00183 Hsp90 protein 0.0088 PF01370 NAD dependent epimerase/dehydratase family 0.0081 PF03098 Animal haem peroxidase 0.0078 PF00227 Proteasome subunit 0.0075 PF03024 Folate receptor family 0.0069 PF00464 Serine hydroxymethyltransferase 0.0067 PF01571 Aminomethyltransferase folate-binding domain 0.0067 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0065 PF00551 Formyl transferase 0.0063 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0063 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0058 PF00171 Aldehyde dehydrogenase family 0.0057 PF02267 ADP-ribosyl cyclase 0.0056 PF02036 SCP-2 sterol transfer family 0.0056 PF01575 MaoC like domain 0.0055 PF00025 ADP-ribosylation factor family 0.0053 PF00493 MCM2/3/5 family 0.0048 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0048 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0048 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0047 PF00305 Lipoxygenase 0.0046 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0046 PF01061 ABC-2 type transporter 0.0046 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0043 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0043 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0039 PF02233 NAD(P), transhydrogenase beta subunit 0.0034 PF08919 F-actin binding 0.0033 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0033 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0031 PF02219 Methylenetetrahydrofolate reductase 0.0031 PF00822 PMP-22/EMP/MP20/Claudin family 0.0031 PF00018 SH3 domain 0.0028 PF01731 Arylesterase 0.0028 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0028 PF00017 SH2 domain 0.0028 PF01180 Dihydroorotate dehydrogenase 0.0028 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0027 PF02059 Interleukin-3 0.0027 PF00999 Sodium/hydrogen exchanger family 0.0026 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0026 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0024 PF03360 Glycosyltransferase family 43 0.0024 PF00028 Cadherin domain 0.0023 PF06448 Domain of Unknown Function (DUF1081), 0.0023 PF12491 Apolipoprotein B100 C terminal 0.0022 PF00571 CBS domain 0.0021 PF00550 Phosphopantetheine attachment site 0.0021 PF00478 IMP dehydrogenase / GMP reductase domain 0.0020 PF01023 S-100/ICaBP type calcium binding domain 0.0018 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0018 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0017 PF00586 AIR synthase related protein, N-terminal domain 0.0017 PF02769 AIR synthase related protein, C-terminal domain 0.0016 PF02911 Formyl transferase, C-terminal domain 0.0016 PF00390 Malic enzyme, N-terminal domain 0.0016 PF03949 Malic enzyme, NAD binding domain 0.0015 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0015 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0015 PF10420 Cytokine interleukin-12p40 C-terminus 0.0013 PF07722 Peptidase C26 0.0013 PF00377 Prion/Doppel alpha-helical domain 0.0012 PF01404 Ephrin receptor ligand binding domain 0.0012 PF01227 GTP cyclohydrolase I 0.0012 PF00536 SAM domain (Sterile alpha motif), 0.0011 PF01347 Lipoprotein amino terminal region 0.0009 PF08403 Amino acid permease N-terminal 0.0009 PF00341 Platelet-derived growth factor (PDGF), 0.0009 PF00264 Common central domain of tyrosinase 0.0008 PF01841 Transglutaminase-like superfamily 0.0008 PF00927 Transglutaminase family, C-terminal ig like domain 0.0008 PF00654 Voltage gated chloride channel 0.0008 PF00656 Caspase domain 0.0008 PF00868 Transglutaminase family 0.0006 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0006 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0005 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0003 PF00340 Interleukin-1 / 18 0.0003 PF02394 Interleukin-1 propeptide 0.0003 PF00676 Dehydrogenase E1 component 0.0003 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0002 PF01916 Deoxyhypusine synthase 0.0001 PF00385 chromo (CHRromatin Organisation MOdifier), domain SUB819 CC1C(C)CCCC1 0.1401 PF02159 Oestrogen receptor 0.1182 PF00105 Zinc finger, C4 type (two domains), 0.1170 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0777 PF00191 Annexin 0.0733 PF02155 Glucocorticoid receptor 0.0591 PF02161 Progesterone receptor 0.0391 PF02166 Androgen receptor 0.0368 PF01735 Lysophospholipase catalytic domain 0.0331 PF08070 DTHCT (NUC029), region 0.0331 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0331 PF00204 DNA gyrase B 0.0330 PF00001 7 transmembrane receptor (rhodopsin family), 0.0329 PF00079 Serpin (serine protease inhibitor), 0.0269 PF03953 Tubulin C-terminal domain 0.0269 PF00091 Tubulin/FtsZ family, GTPase domain 0.0264 PF08035 Opioids neuropeptide 0.0264 PF08384 Pro-opiomelanocortin, N-terminal region 0.0264 PF00976 Corticotropin ACTH domain 0.0187 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0179 PF12497 Estrogen receptor beta 0.0155 PF00168 C2 domain 0.0129 PF00005 ABC transporter 0.0126 PF00989 PAS fold 0.0115 PF00664 ABC transporter transmembrane region 0.0113 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0105 PF00027 Cyclic nucleotide-binding domain 0.0097 PF11825 Protein of unknown function (DUF3345), 0.0087 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0076 PF01477 PLAT/LH2 domain 0.0069 PF00067 Cytochrome P450 0.0067 PF00273 Serum albumin family 0.0055 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0054 PF03414 Glycosyltransferase family 6 0.0054 PF00305 Lipoxygenase 0.0049 PF00822 PMP-22/EMP/MP20/Claudin family 0.0049 PF07648 Kazal-type serine protease inhibitor domain 0.0045 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0040 PF00643 B-box zinc finger 0.0038 PF01429 Methyl-CpG binding domain 0.0037 PF02806 Alpha amylase, C-terminal all-beta domain 0.0037 PF00106 short chain dehydrogenase 0.0036 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0031 PF03098 Animal haem peroxidase 0.0030 PF08491 Squalene epoxidase 0.0030 PF00040 Fibronectin type II domain 0.0029 PF07966 A1 Propeptide 0.0028 PF06327 Domain of Unknown Function (DUF1053), 0.0028 PF02180 Bcl-2 homology region 4 0.0028 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0024 PF01401 Angiotensin-converting enzyme 0.0024 PF01122 Eukaryotic cobalamin-binding protein 0.0024 PF00653 Inhibitor of Apoptosis domain 0.0024 PF00918 Gastrin/cholecystokinin family 0.0023 PF00026 Eukaryotic aspartyl protease 0.0022 PF00183 Hsp90 protein 0.0021 PF04622 ERG2 and Sigma1 receptor like protein 0.0019 PF00170 bZIP transcription factor 0.0017 PF02173 pKID domain 0.0017 PF01160 Vertebrate endogenous opioids neuropeptide 0.0017 PF03765 CRAL/TRIO, N-terminus 0.0017 PF00212 Atrial natriuretic peptide 0.0017 PF02394 Interleukin-1 propeptide 0.0017 PF00554 Rel homology domain (RHD), 0.0017 PF00031 Cystatin domain 0.0017 PF00650 CRAL/TRIO domain 0.0017 PF00340 Interleukin-1 / 18 0.0016 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0015 PF00762 Ferrochelatase 0.0015 PF01642 Methylmalonyl-CoA mutase 0.0015 PF03308 ArgK protein 0.0015 PF08763 Voltage gated calcium channel IQ domain 0.0015 PF01923 Cobalamin adenosyltransferase 0.0015 PF00656 Caspase domain 0.0014 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0014 PF08377 MAP2/Tau projection domain 0.0014 PF00151 Lipase 0.0011 PF00884 Sulfatase 0.0011 PF00377 Prion/Doppel alpha-helical domain 0.0011 PF02310 B12 binding domain 0.0010 PF06907 Latexin 0.0010 PF03572 Peptidase family S41 0.0010 PF00625 Guanylate kinase 0.0010 PF01061 ABC-2 type transporter 0.0009 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0009 PF00969 Class II histocompatibility antigen, beta domain 0.0009 PF00059 Lectin C-type domain 0.0008 PF00341 Platelet-derived growth factor (PDGF), 0.0008 PF00531 Death domain 0.0007 PF08441 Integrin alpha 0.0007 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0005 PF00229 TNF(Tumour Necrosis Factor), family 0.0005 PF00714 Interferon gamma 0.0005 PF00357 Integrin alpha cytoplasmic region 0.0005 PF03957 Jun-like transcription factor 0.0005 PF00432 Prenyltransferase and squalene oxidase repeat 0.0005 PF00489 Interleukin-6/G-CSF/MGF family 0.0004 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0004 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0003 PF00688 TGF-beta propeptide 0.0003 PF01244 Membrane dipeptidase (Peptidase family M19), 0.0003 PF00108 Thiolase, N-terminal domain 0.0003 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0003 PF00439 Bromodomain 0.0003 PF00019 Transforming growth factor beta like domain 0.0003 PF00890 FAD binding domain 0.0003 PF02803 Thiolase, C-terminal domain 0.0003 PF00020 TNFR/NGFR cysteine-rich region 0.0003 PF01327 Polypeptide deformylase 0.0003 PF00128 Alpha amylase, catalytic domain 0.0002 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0002 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0002 PF02260 FATC domain 0.0002 PF02259 FAT domain 0.0002 PF08771 Rapamycin binding domain 0.0001 PF01425 Amidase SUB549 O-C-C:C 0.1380 PF02159 Oestrogen receptor 0.0728 PF00001 7 transmembrane receptor (rhodopsin family), 0.0597 PF00105 Zinc finger, C4 type (two domains), 0.0582 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0557 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0557 PF00204 DNA gyrase B 0.0557 PF08070 DTHCT (NUC029), region 0.0278 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0270 PF12497 Estrogen receptor beta 0.0269 PF00576 HIUase/Transthyretin family 0.0217 PF08384 Pro-opiomelanocortin, N-terminal region 0.0217 PF00976 Corticotropin ACTH domain 0.0217 PF08035 Opioids neuropeptide 0.0207 PF00102 Protein-tyrosine phosphatase 0.0203 PF00989 PAS fold 0.0201 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0166 PF00027 Cyclic nucleotide-binding domain 0.0162 PF00005 ABC transporter 0.0160 PF00664 ABC transporter transmembrane region 0.0136 PF11825 Protein of unknown function (DUF3345), 0.0114 PF00643 B-box zinc finger 0.0105 PF01596 O-methyltransferase 0.0077 PF01477 PLAT/LH2 domain 0.0076 PF00305 Lipoxygenase 0.0072 PF02394 Interleukin-1 propeptide 0.0072 PF00340 Interleukin-1 / 18 0.0072 PF03062 MBOAT family 0.0061 PF08983 Domain of unknown function (DUF1856), 0.0043 PF04622 ERG2 and Sigma1 receptor like protein 0.0038 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0038 PF00656 Caspase domain 0.0038 PF00183 Hsp90 protein 0.0037 PF01160 Vertebrate endogenous opioids neuropeptide 0.0037 PF00918 Gastrin/cholecystokinin family 0.0026 PF01588 Putative tRNA binding domain 0.0026 PF01180 Dihydroorotate dehydrogenase 0.0025 PF00135 Carboxylesterase 0.0024 PF00650 CRAL/TRIO domain 0.0024 PF08377 MAP2/Tau projection domain 0.0024 PF03765 CRAL/TRIO, N-terminus 0.0024 PF02180 Bcl-2 homology region 4 0.0024 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0024 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0023 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0023 PF02460 Patched family 0.0022 PF00377 Prion/Doppel alpha-helical domain 0.0021 PF06327 Domain of Unknown Function (DUF1053), 0.0021 PF08441 Integrin alpha 0.0021 PF00884 Sulfatase 0.0019 PF00625 Guanylate kinase 0.0018 PF00357 Integrin alpha cytoplasmic region 0.0018 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0014 PF09396 Thrombin light chain 0.0014 PF07885 Ion channel 0.0012 PF00229 TNF(Tumour Necrosis Factor), family 0.0011 PF00341 Platelet-derived growth factor (PDGF), 0.0010 PF00002 7 transmembrane receptor (Secretin family), 0.0010 PF02793 Hormone receptor domain 0.0009 PF02025 Interleukin 5 0.0009 PF02201 SWIB/MDM2 domain 0.0009 PF09193 Cholecystokinin A receptor, N-terminal 0.0009 PF08763 Voltage gated calcium channel IQ domain 0.0009 PF00094 von Willebrand factor type D domain 0.0009 PF08742 C8 domain 0.0009 PF00641 Zn-finger in Ran binding protein and others 0.0009 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0008 PF00068 Phospholipase A2 0.0008 PF00170 bZIP transcription factor 0.0006 PF00757 Furin-like cysteine rich region 0.0006 PF00266 Aminotransferase class-V 0.0006 PF01030 Receptor L domain 0.0006 PF00091 Tubulin/FtsZ family, GTPase domain 0.0006 PF03953 Tubulin C-terminal domain 0.0005 PF00620 RhoGAP domain 0.0005 PF01733 Nucleoside transporter 0.0005 PF02173 pKID domain 0.0004 PF01347 Lipoprotein amino terminal region 0.0003 PF00151 Lipase SUB253 >= 1 unsaturated non-aromatic carbon-only ring size 10 0.1379 PF02159 Oestrogen receptor 0.1170 PF02155 Glucocorticoid receptor 0.1167 PF00191 Annexin 0.1017 PF00105 Zinc finger, C4 type (two domains), 0.1015 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0999 PF02161 Progesterone receptor 0.0764 PF02166 Androgen receptor 0.0547 PF01735 Lysophospholipase catalytic domain 0.0454 PF00079 Serpin (serine protease inhibitor), 0.0218 PF00168 C2 domain 0.0174 PF12497 Estrogen receptor beta 0.0142 PF08035 Opioids neuropeptide 0.0142 PF00976 Corticotropin ACTH domain 0.0142 PF08384 Pro-opiomelanocortin, N-terminal region 0.0113 PF00690 Cation transporter/ATPase, N-terminus 0.0113 PF00689 Cation transporting ATPase, C-terminus 0.0101 PF00122 E1-E2 ATPase 0.0085 PF00702 haloacid dehalogenase-like hydrolase 0.0076 PF00554 Rel homology domain (RHD), 0.0076 PF07648 Kazal-type serine protease inhibitor domain 0.0076 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0074 PF00031 Cystatin domain 0.0074 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0070 PF00212 Atrial natriuretic peptide 0.0064 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0064 PF08377 MAP2/Tau projection domain 0.0055 PF00067 Cytochrome P450 0.0053 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0051 PF01607 Chitin binding Peritrophin-A domain 0.0051 PF00704 Glycosyl hydrolases family 18 0.0049 PF00039 Fibronectin type I domain 0.0044 PF02898 Nitric oxide synthase, oxygenase domain 0.0039 PF00106 short chain dehydrogenase 0.0039 PF00531 Death domain 0.0038 PF00762 Ferrochelatase 0.0033 PF09164 Vitamin D binding protein, domain III 0.0033 PF00654 Voltage gated chloride channel 0.0031 PF02180 Bcl-2 homology region 4 0.0031 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0026 PF00305 Lipoxygenase 0.0026 PF00667 FAD binding domain 0.0026 PF00258 Flavodoxin 0.0022 PF00884 Sulfatase 0.0022 PF02038 ATP1G1/PLM/MAT8 family 0.0021 PF00175 Oxidoreductase NAD-binding domain 0.0021 PF00432 Prenyltransferase and squalene oxidase repeat 0.0020 PF07884 Vitamin K epoxide reductase family 0.0014 PF00023 Ankyrin repeat 0.0010 PF00341 Platelet-derived growth factor (PDGF), 0.0009 PF02210 Laminin G domain 0.0009 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0009 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0009 PF00377 Prion/Doppel alpha-helical domain 0.0009 PF04756 OST3 / OST6 family 0.0009 PF01477 PLAT/LH2 domain 0.0009 PF00969 Class II histocompatibility antigen, beta domain 0.0009 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0008 PF01593 Flavin containing amine oxidoreductase 0.0005 PF00675 Insulinase (Peptidase family M16), 0.0005 PF00688 TGF-beta propeptide 0.0005 PF00020 TNFR/NGFR cysteine-rich region 0.0005 PF05193 Peptidase M16 inactive domain 0.0005 PF01429 Methyl-CpG binding domain 0.0005 PF00019 Transforming growth factor beta like domain 0.0004 PF00714 Interferon gamma 0.0004 PF00340 Interleukin-1 / 18 0.0004 PF02394 Interleukin-1 propeptide 0.0002 PF01431 Peptidase family M13 0.0002 PF01391 Collagen triple helix repeat (20 copies), 0.0002 PF00656 Caspase domain 0.0002 PF05649 Peptidase family M13 SUB31 >= 1 P 0.1379 PF02223 Thymidylate kinase 0.1106 PF00348 Polyprenyl synthetase 0.0745 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0729 PF08240 Alcohol dehydrogenase GroES-like domain 0.0666 PF03770 Inositol polyphosphate kinase 0.0627 PF00107 Zinc-binding dehydrogenase 0.0590 PF00106 short chain dehydrogenase 0.0569 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0552 PF02267 ADP-ribosyl cyclase 0.0548 PF00102 Protein-tyrosine phosphatase 0.0475 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0475 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0473 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0473 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0473 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0455 PF01370 NAD dependent epimerase/dehydratase family 0.0404 PF00248 Aldo/keto reductase family 0.0382 PF00171 Aldehyde dehydrogenase family 0.0366 PF01467 Cytidylyltransferase 0.0293 PF00478 IMP dehydrogenase / GMP reductase domain 0.0278 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0278 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0275 PF01122 Eukaryotic cobalamin-binding protein 0.0212 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0204 PF02310 B12 binding domain 0.0193 PF03308 ArgK protein 0.0193 PF01642 Methylmalonyl-CoA mutase 0.0193 PF01923 Cobalamin adenosyltransferase 0.0173 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0161 PF00571 CBS domain 0.0137 PF00169 PH domain 0.0111 PF08674 Acetylcholinesterase tetramerisation domain 0.0108 PF00225 Kinesin motor domain 0.0103 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0099 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0099 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0092 PF02607 B12 binding domain 0.0092 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0092 PF00809 Pterin binding enzyme 0.0090 PF00155 Aminotransferase class I and II 0.0090 PF00431 CUB domain 0.0089 PF03360 Glycosyltransferase family 43 0.0086 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0085 PF00258 Flavodoxin 0.0085 PF00667 FAD binding domain 0.0085 PF00266 Aminotransferase class-V 0.0084 PF08676 MutL C terminal dimerisation domain 0.0084 PF12473 Kinesin protein 0.0084 PF12423 Kinesin protein 1B 0.0084 PF01119 DNA mismatch repair protein, C-terminal domain 0.0084 PF00498 FHA domain 0.0083 PF00175 Oxidoreductase NAD-binding domain 0.0083 PF00501 AMP-binding enzyme 0.0082 PF00069 Protein kinase domain 0.0081 PF03949 Malic enzyme, NAD binding domain 0.0081 PF02036 SCP-2 sterol transfer family 0.0081 PF00390 Malic enzyme, N-terminal domain 0.0081 PF01652 Eukaryotic initiation factor 4E 0.0081 PF01575 MaoC like domain 0.0080 PF00970 Oxidoreductase FAD-binding domain 0.0070 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0070 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0069 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0069 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0063 PF00400 WD domain, G-beta repeat 0.0063 PF00931 NB-ARC domain 0.0063 PF00464 Serine hydroxymethyltransferase 0.0060 PF02233 NAD(P), transhydrogenase beta subunit 0.0059 PF07645 Calcium-binding EGF domain 0.0056 PF00291 Pyridoxal-phosphate dependent enzyme 0.0054 PF00202 Aminotransferase class-III 0.0051 PF01063 Aminotransferase class IV 0.0050 PF00343 Carbohydrate phosphorylase 0.0050 PF00018 SH3 domain 0.0047 PF02574 Homocysteine S-methyltransferase 0.0046 PF00071 Ras family 0.0042 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0042 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0039 PF00074 Pancreatic ribonuclease 0.0036 PF00294 pfkB family carbohydrate kinase 0.0029 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0028 PF00702 haloacid dehalogenase-like hydrolase 0.0025 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0025 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0022 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0022 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0021 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0021 PF01202 Shikimate kinase 0.0021 PF02347 Glycine cleavage system P-protein 0.0021 PF01168 Alanine racemase, N-terminal domain 0.0021 PF03473 MOSC domain 0.0021 PF03476 MOSC N-terminal beta barrel domain 0.0021 PF01212 Beta-eliminating lyase 0.0021 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0020 PF02971 Formiminotransferase domain 0.0020 PF04961 Formiminotransferase-cyclodeaminase 0.0020 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0020 PF07706 Aminotransferase ubiquitination site 0.0017 PF01126 Heme oxygenase 0.0015 PF01596 O-methyltransferase 0.0010 PF00349 Hexokinase 0.0010 PF03727 Hexokinase 0.0007 PF00058 Low-density lipoprotein receptor repeat class B 0.0007 PF00057 Low-density lipoprotein receptor domain class A 0.0007 PF01268 Formate--tetrahydrofolate ligase 0.0007 PF01687 Riboflavin kinase 0.0006 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0006 PF02525 Flavodoxin-like fold 0.0006 PF00017 SH2 domain 0.0006 PF00186 Dihydrofolate reductase 0.0006 PF00676 Dehydrogenase E1 component 0.0005 PF01230 HIT domain 0.0005 PF02394 Interleukin-1 propeptide 0.0005 PF00342 Phosphoglucose isomerase 0.0005 PF00340 Interleukin-1 / 18 0.0004 PF00378 Enoyl-CoA hydratase/isomerase family 0.0004 PF01437 Plexin repeat 0.0004 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0004 PF01833 IPT/TIG domain 0.0004 PF00690 Cation transporter/ATPase, N-terminus 0.0004 PF00689 Cation transporting ATPase, C-terminus 0.0004 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0004 PF05347 Complex 1 protein (LYR family), 0.0004 PF01403 Sema domain 0.0004 PF02779 Transketolase, pyrimidine binding domain 0.0004 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0004 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0003 PF00576 HIUase/Transthyretin family 0.0003 PF01916 Deoxyhypusine synthase 0.0003 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0003 PF00122 E1-E2 ATPase 0.0003 PF01588 Putative tRNA binding domain 0.0002 PF00794 PI3-kinase family, ras-binding domain 0.0002 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF08040 MNLL subunit 0.0002 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0002 PF00204 DNA gyrase B 0.0002 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0002 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0002 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0002 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0002 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0002 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0002 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0002 PF00384 Molybdopterin oxidoreductase 0.0002 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0002 PF08070 DTHCT (NUC029), region 0.0002 PF09326 Domain of unknown function (DUF1982), 0.0002 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0002 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0002 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0002 PF02466 Tim17/Tim22/Tim23 family 0.0002 PF04716 ETC complex I subunit conserved region 0.0002 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0002 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0002 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0002 PF01808 AICARFT/IMPCHase bienzyme 0.0002 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0002 PF06212 GRIM-19 protein 0.0002 PF10276 Zinc-finger domain 0.0002 PF09166 Biliverdin reductase, catalytic 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0002 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0002 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0002 PF02817 e3 binding domain 0.0002 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0002 PF04800 ETC complex I subunit conserved region 0.0002 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0002 PF10531 SLBB domain 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0002 PF04116 Fatty acid hydroxylase superfamily 0.0002 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0002 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0002 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0002 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0002 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0002 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0002 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0002 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF00149 Calcineurin-like phosphoesterase 0.0001 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0001 PF00962 Adenosine/AMP deaminase 0.0001 PF00042 Globin 0.0001 PF00170 bZIP transcription factor 0.0001 PF02780 Transketolase, C-terminal domain 0.0001 PF00406 Adenylate kinase 0.0001 PF08515 Transforming growth factor beta type I GS-motif 0.0001 PF01064 Activin types I and II receptor domain 0.0001 PF03435 Saccharopine dehydrogenase 0.0001 PF02173 pKID domain SUB341 C(~C)(~C)(~N) 0.1362 PF00001 7 transmembrane receptor (rhodopsin family), 0.0357 PF03073 TspO/MBR family 0.0234 PF00209 Sodium:neurotransmitter symporter family 0.0231 PF01401 Angiotensin-converting enzyme 0.0227 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0224 PF06512 Sodium ion transport-associated 0.0215 PF00005 ABC transporter 0.0188 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0184 PF00664 ABC transporter transmembrane region 0.0143 PF00989 PAS fold 0.0132 PF01593 Flavin containing amine oxidoreductase 0.0130 PF00520 Ion transport protein 0.0127 PF00069 Protein kinase domain 0.0120 PF00186 Dihydrofolate reductase 0.0117 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0117 PF00027 Cyclic nucleotide-binding domain 0.0117 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0095 PF01048 Phosphorylase superfamily 0.0072 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0057 PF08070 DTHCT (NUC029), region 0.0057 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0057 PF00204 DNA gyrase B 0.0054 PF03953 Tubulin C-terminal domain 0.0054 PF00091 Tubulin/FtsZ family, GTPase domain 0.0041 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0041 PF02180 Bcl-2 homology region 4 0.0037 PF01061 ABC-2 type transporter 0.0036 PF08983 Domain of unknown function (DUF1856), 0.0035 PF00017 SH2 domain 0.0016 PF08491 Squalene epoxidase 0.0015 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0015 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0014 PF08919 F-actin binding 0.0012 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0009 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0009 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0009 PF00018 SH3 domain 0.0006 PF01467 Cytidylyltransferase 0.0005 PF02223 Thymidylate kinase 0.0003 PF00962 Adenosine/AMP deaminase 0.0002 PF01126 Heme oxygenase 0.0001 PF09396 Thrombin light chain SUB699 O-C-C-C-C-C-C-C 0.1334 PF02159 Oestrogen receptor 0.0966 PF00105 Zinc finger, C4 type (two domains), 0.0957 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0838 PF00001 7 transmembrane receptor (rhodopsin family), 0.0818 PF00204 DNA gyrase B 0.0818 PF08070 DTHCT (NUC029), region 0.0818 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0674 PF00191 Annexin 0.0617 PF02155 Glucocorticoid receptor 0.0523 PF02161 Progesterone receptor 0.0373 PF02166 Androgen receptor 0.0343 PF01735 Lysophospholipase catalytic domain 0.0337 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0277 PF00079 Serpin (serine protease inhibitor), 0.0212 PF08035 Opioids neuropeptide 0.0212 PF00976 Corticotropin ACTH domain 0.0212 PF08384 Pro-opiomelanocortin, N-terminal region 0.0179 PF12497 Estrogen receptor beta 0.0163 PF00005 ABC transporter 0.0157 PF01401 Angiotensin-converting enzyme 0.0149 PF00664 ABC transporter transmembrane region 0.0138 PF09396 Thrombin light chain 0.0137 PF00168 C2 domain 0.0108 PF00091 Tubulin/FtsZ family, GTPase domain 0.0108 PF03953 Tubulin C-terminal domain 0.0104 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0102 PF00989 PAS fold 0.0092 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0081 PF00186 Dihydrofolate reductase 0.0079 PF07884 Vitamin K epoxide reductase family 0.0076 PF00027 Cyclic nucleotide-binding domain 0.0049 PF00042 Globin 0.0039 PF00305 Lipoxygenase 0.0038 PF00051 Kringle domain 0.0038 PF11825 Protein of unknown function (DUF3345), 0.0037 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0037 PF00067 Cytochrome P450 0.0032 PF01061 ABC-2 type transporter 0.0030 PF00643 B-box zinc finger 0.0024 PF00229 TNF(Tumour Necrosis Factor), family 0.0024 PF02394 Interleukin-1 propeptide 0.0024 PF00340 Interleukin-1 / 18 0.0023 PF07648 Kazal-type serine protease inhibitor domain 0.0022 PF04622 ERG2 and Sigma1 receptor like protein 0.0020 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0017 PF00554 Rel homology domain (RHD), 0.0016 PF06327 Domain of Unknown Function (DUF1053), 0.0016 PF01477 PLAT/LH2 domain 0.0015 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0014 PF00357 Integrin alpha cytoplasmic region 0.0013 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0012 PF08441 Integrin alpha 0.0011 PF00650 CRAL/TRIO domain 0.0011 PF03765 CRAL/TRIO, N-terminus 0.0010 PF07885 Ion channel 0.0009 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0009 PF03062 MBOAT family 0.0008 PF02259 FAT domain 0.0008 PF08771 Rapamycin binding domain 0.0008 PF02260 FATC domain 0.0006 PF00212 Atrial natriuretic peptide 0.0006 PF00341 Platelet-derived growth factor (PDGF), 0.0003 PF02180 Bcl-2 homology region 4 0.0003 PF00452 Apoptosis regulator proteins, Bcl-2 family SUB340 C(~C)(~C)(~H)(~O) 0.1324 PF00191 Annexin 0.1220 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.1156 PF02806 Alpha amylase, C-terminal all-beta domain 0.1085 PF02155 Glucocorticoid receptor 0.0810 PF00128 Alpha amylase, catalytic domain 0.0787 PF03414 Glycosyltransferase family 6 0.0715 PF00079 Serpin (serine protease inhibitor), 0.0652 PF01048 Phosphorylase superfamily 0.0565 PF00091 Tubulin/FtsZ family, GTPase domain 0.0565 PF03953 Tubulin C-terminal domain 0.0498 PF02223 Thymidylate kinase 0.0409 PF01735 Lysophospholipase catalytic domain 0.0370 PF00303 Thymidylate synthase 0.0322 PF00106 short chain dehydrogenase 0.0265 PF00059 Lectin C-type domain 0.0259 PF00167 Fibroblast growth factor 0.0227 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0215 PF03770 Inositol polyphosphate kinase 0.0192 PF00005 ABC transporter 0.0183 PF01607 Chitin binding Peritrophin-A domain 0.0183 PF00704 Glycosyl hydrolases family 18 0.0167 PF01467 Cytidylyltransferase 0.0140 PF00084 Sushi domain (SCR repeat), 0.0139 PF00664 ABC transporter transmembrane region 0.0136 PF02267 ADP-ribosyl cyclase 0.0133 PF00171 Aldehyde dehydrogenase family 0.0128 PF03727 Hexokinase 0.0128 PF00349 Hexokinase 0.0124 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0124 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0121 PF07654 Immunoglobulin C1-set domain 0.0116 PF08035 Opioids neuropeptide 0.0116 PF08384 Pro-opiomelanocortin, N-terminal region 0.0116 PF00976 Corticotropin ACTH domain 0.0114 PF01370 NAD dependent epimerase/dehydratase family 0.0113 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.0096 PF01532 Glycosyl hydrolase family 47 0.0081 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0081 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0081 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0066 PF08240 Alcohol dehydrogenase GroES-like domain 0.0043 PF00248 Aldo/keto reductase family 0.0039 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0037 PF00107 Zinc-binding dehydrogenase 0.0035 PF00143 Interferon alpha/beta domain 0.0034 PF01687 Riboflavin kinase 0.0033 PF00071 Ras family 0.0023 PF01842 ACT domain 0.0022 PF01230 HIT domain 0.0022 PF01122 Eukaryotic cobalamin-binding protein 0.0018 PF00571 CBS domain 0.0013 PF03360 Glycosyltransferase family 43 0.0006 PF00088 Trefoil (P-type), domain 0.0006 PF01055 Glycosyl hydrolases family 31 0.0001 PF00229 TNF(Tumour Necrosis Factor), family SUB777 CC1CCC(C)CC1 0.1317 PF00105 Zinc finger, C4 type (two domains), 0.1317 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1286 PF02159 Oestrogen receptor 0.1113 PF00191 Annexin 0.1042 PF02155 Glucocorticoid receptor 0.0912 PF02161 Progesterone receptor 0.0689 PF02166 Androgen receptor 0.0508 PF01735 Lysophospholipase catalytic domain 0.0420 PF00079 Serpin (serine protease inhibitor), 0.0362 PF08035 Opioids neuropeptide 0.0362 PF00976 Corticotropin ACTH domain 0.0362 PF08384 Pro-opiomelanocortin, N-terminal region 0.0251 PF03953 Tubulin C-terminal domain 0.0251 PF00091 Tubulin/FtsZ family, GTPase domain 0.0200 PF00168 C2 domain 0.0178 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0177 PF11825 Protein of unknown function (DUF3345), 0.0144 PF12497 Estrogen receptor beta 0.0097 PF01429 Methyl-CpG binding domain 0.0095 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0094 PF00106 short chain dehydrogenase 0.0093 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0089 PF00643 B-box zinc finger 0.0087 PF00305 Lipoxygenase 0.0084 PF07648 Kazal-type serine protease inhibitor domain 0.0078 PF08491 Squalene epoxidase 0.0076 PF00040 Fibronectin type II domain 0.0074 PF00067 Cytochrome P450 0.0072 PF06327 Domain of Unknown Function (DUF1053), 0.0068 PF02180 Bcl-2 homology region 4 0.0068 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0062 PF00918 Gastrin/cholecystokinin family 0.0062 PF01122 Eukaryotic cobalamin-binding protein 0.0061 PF00653 Inhibitor of Apoptosis domain 0.0059 PF01477 PLAT/LH2 domain 0.0055 PF04622 ERG2 and Sigma1 receptor like protein 0.0048 PF00170 bZIP transcription factor 0.0044 PF02173 pKID domain 0.0044 PF00212 Atrial natriuretic peptide 0.0044 PF01160 Vertebrate endogenous opioids neuropeptide 0.0043 PF00031 Cystatin domain 0.0043 PF00554 Rel homology domain (RHD), 0.0040 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0040 PF03765 CRAL/TRIO, N-terminus 0.0040 PF00650 CRAL/TRIO domain 0.0038 PF00656 Caspase domain 0.0038 PF01923 Cobalamin adenosyltransferase 0.0038 PF03308 ArgK protein 0.0038 PF01642 Methylmalonyl-CoA mutase 0.0037 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0037 PF08377 MAP2/Tau projection domain 0.0037 PF00762 Ferrochelatase 0.0028 PF02310 B12 binding domain 0.0027 PF00377 Prion/Doppel alpha-helical domain 0.0027 PF00884 Sulfatase 0.0026 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0025 PF00204 DNA gyrase B 0.0025 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0025 PF00625 Guanylate kinase 0.0025 PF08070 DTHCT (NUC029), region 0.0024 PF06907 Latexin 0.0024 PF03572 Peptidase family S41 0.0024 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0024 PF00969 Class II histocompatibility antigen, beta domain 0.0022 PF00183 Hsp90 protein 0.0021 PF02394 Interleukin-1 propeptide 0.0021 PF00340 Interleukin-1 / 18 0.0021 PF00531 Death domain 0.0020 PF00341 Platelet-derived growth factor (PDGF), 0.0019 PF08763 Voltage gated calcium channel IQ domain 0.0017 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0014 PF00714 Interferon gamma 0.0013 PF00489 Interleukin-6/G-CSF/MGF family 0.0012 PF00432 Prenyltransferase and squalene oxidase repeat 0.0012 PF03957 Jun-like transcription factor 0.0012 PF00357 Integrin alpha cytoplasmic region 0.0010 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0010 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0007 PF00439 Bromodomain 0.0007 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0007 PF00108 Thiolase, N-terminal domain 0.0007 PF01244 Membrane dipeptidase (Peptidase family M19), 0.0007 PF00020 TNFR/NGFR cysteine-rich region 0.0007 PF00019 Transforming growth factor beta like domain 0.0007 PF02803 Thiolase, C-terminal domain 0.0007 PF00688 TGF-beta propeptide 0.0007 PF00890 FAD binding domain 0.0007 PF01327 Polypeptide deformylase 0.0004 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0004 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0002 PF08441 Integrin alpha 0.0002 PF01425 Amidase 0.0001 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0001 PF00229 TNF(Tumour Necrosis Factor), family SUB250 >= 1 saturated or aromatic carbon-only ring size 10 0.1315 PF00105 Zinc finger, C4 type (two domains), 0.1314 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1284 PF02159 Oestrogen receptor 0.1111 PF00191 Annexin 0.1040 PF02155 Glucocorticoid receptor 0.0910 PF02161 Progesterone receptor 0.0687 PF02166 Androgen receptor 0.0507 PF01735 Lysophospholipase catalytic domain 0.0419 PF00079 Serpin (serine protease inhibitor), 0.0361 PF00976 Corticotropin ACTH domain 0.0361 PF08035 Opioids neuropeptide 0.0361 PF08384 Pro-opiomelanocortin, N-terminal region 0.0250 PF03953 Tubulin C-terminal domain 0.0250 PF00091 Tubulin/FtsZ family, GTPase domain 0.0199 PF00168 C2 domain 0.0177 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0176 PF11825 Protein of unknown function (DUF3345), 0.0144 PF12497 Estrogen receptor beta 0.0097 PF01429 Methyl-CpG binding domain 0.0095 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0094 PF00106 short chain dehydrogenase 0.0092 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0089 PF00643 B-box zinc finger 0.0087 PF00305 Lipoxygenase 0.0084 PF07648 Kazal-type serine protease inhibitor domain 0.0078 PF08491 Squalene epoxidase 0.0076 PF00040 Fibronectin type II domain 0.0074 PF00067 Cytochrome P450 0.0072 PF06327 Domain of Unknown Function (DUF1053), 0.0068 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0068 PF02180 Bcl-2 homology region 4 0.0062 PF01122 Eukaryotic cobalamin-binding protein 0.0062 PF00918 Gastrin/cholecystokinin family 0.0061 PF00653 Inhibitor of Apoptosis domain 0.0059 PF01477 PLAT/LH2 domain 0.0055 PF04622 ERG2 and Sigma1 receptor like protein 0.0048 PF00170 bZIP transcription factor 0.0044 PF00212 Atrial natriuretic peptide 0.0044 PF02173 pKID domain 0.0044 PF01160 Vertebrate endogenous opioids neuropeptide 0.0043 PF00031 Cystatin domain 0.0043 PF00554 Rel homology domain (RHD), 0.0040 PF00650 CRAL/TRIO domain 0.0040 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0040 PF03765 CRAL/TRIO, N-terminus 0.0038 PF03308 ArgK protein 0.0038 PF01923 Cobalamin adenosyltransferase 0.0038 PF01642 Methylmalonyl-CoA mutase 0.0037 PF00656 Caspase domain 0.0037 PF00762 Ferrochelatase 0.0037 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0037 PF08377 MAP2/Tau projection domain 0.0028 PF02310 B12 binding domain 0.0027 PF00884 Sulfatase 0.0027 PF00377 Prion/Doppel alpha-helical domain 0.0026 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0025 PF08070 DTHCT (NUC029), region 0.0025 PF00625 Guanylate kinase 0.0025 PF00204 DNA gyrase B 0.0025 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0024 PF06907 Latexin 0.0024 PF00969 Class II histocompatibility antigen, beta domain 0.0024 PF03572 Peptidase family S41 0.0024 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0022 PF00183 Hsp90 protein 0.0021 PF02394 Interleukin-1 propeptide 0.0021 PF00531 Death domain 0.0021 PF00340 Interleukin-1 / 18 0.0020 PF00341 Platelet-derived growth factor (PDGF), 0.0019 PF08763 Voltage gated calcium channel IQ domain 0.0017 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0014 PF00714 Interferon gamma 0.0013 PF00489 Interleukin-6/G-CSF/MGF family 0.0012 PF00357 Integrin alpha cytoplasmic region 0.0012 PF03957 Jun-like transcription factor 0.0012 PF00432 Prenyltransferase and squalene oxidase repeat 0.0010 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0010 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0007 PF00890 FAD binding domain 0.0007 PF00108 Thiolase, N-terminal domain 0.0007 PF01327 Polypeptide deformylase 0.0007 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0007 PF02803 Thiolase, C-terminal domain 0.0007 PF00439 Bromodomain 0.0007 PF00688 TGF-beta propeptide 0.0007 PF00020 TNFR/NGFR cysteine-rich region 0.0007 PF01244 Membrane dipeptidase (Peptidase family M19), 0.0007 PF00019 Transforming growth factor beta like domain 0.0004 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0004 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0002 PF01425 Amidase 0.0002 PF08441 Integrin alpha 0.0001 PF00229 TNF(Tumour Necrosis Factor), family 0.0001 PF00368 Hydroxymethylglutaryl-coenzyme A reductase SUB394 N(~C)(~H) 0.1312 PF00194 Eukaryotic-type carbonic anhydrase 0.0362 PF01048 Phosphorylase superfamily 0.0333 PF00186 Dihydrofolate reductase 0.0319 PF00303 Thymidylate synthase 0.0281 PF02223 Thymidylate kinase 0.0251 PF00324 Amino acid permease 0.0221 PF08403 Amino acid permease N-terminal 0.0218 PF00478 IMP dehydrogenase / GMP reductase domain 0.0208 PF00107 Zinc-binding dehydrogenase 0.0199 PF00069 Protein kinase domain 0.0199 PF08240 Alcohol dehydrogenase GroES-like domain 0.0196 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0185 PF02806 Alpha amylase, C-terminal all-beta domain 0.0181 PF01842 ACT domain 0.0177 PF02898 Nitric oxide synthase, oxygenase domain 0.0154 PF00128 Alpha amylase, catalytic domain 0.0149 PF02254 TrkA-N domain 0.0149 PF00310 Glutamine amidotransferases class-II 0.0149 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0137 PF06512 Sodium ion transport-associated 0.0134 PF02798 Glutathione S-transferase, N-terminal domain 0.0131 PF00043 Glutathione S-transferase, C-terminal domain 0.0131 PF00156 Phosphoribosyl transferase domain 0.0130 PF00175 Oxidoreductase NAD-binding domain 0.0122 PF00667 FAD binding domain 0.0122 PF00258 Flavodoxin 0.0121 PF00962 Adenosine/AMP deaminase 0.0115 PF01426 BAH domain 0.0115 PF02008 CXXC zinc finger domain 0.0115 PF06464 DMAP1-binding Domain 0.0108 PF00733 Asparagine synthase 0.0107 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0097 PF00571 CBS domain 0.0096 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0079 PF01841 Transglutaminase-like superfamily 0.0079 PF00868 Transglutaminase family 0.0079 PF00927 Transglutaminase family, C-terminal ig like domain 0.0078 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0077 PF00317 Ribonucleotide reductase, all-alpha domain 0.0077 PF03477 ATP cone domain 0.0077 PF02867 Ribonucleotide reductase, barrel domain 0.0076 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0074 PF09396 Thrombin light chain 0.0072 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0072 PF00764 Arginosuccinate synthase 0.0072 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0069 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0067 PF00958 GMP synthase C terminal domain 0.0064 PF00145 C-5 cytosine-specific DNA methylase 0.0063 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0063 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0061 PF00117 Glutamine amidotransferase class-I 0.0059 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0059 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0057 PF03199 Eukaryotic glutathione synthase 0.0057 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0057 PF01268 Formate--tetrahydrofolate ligase 0.0055 PF01063 Aminotransferase class IV 0.0048 PF00858 Amiloride-sensitive sodium channel 0.0041 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0041 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0039 PF01401 Angiotensin-converting enzyme 0.0036 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0036 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0034 PF02142 MGS-like domain 0.0034 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0032 PF01370 NAD dependent epimerase/dehydratase family 0.0027 PF00051 Kringle domain 0.0026 PF01490 Transmembrane amino acid transporter protein 0.0024 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0023 PF01467 Cytidylyltransferase 0.0021 PF02267 ADP-ribosyl cyclase 0.0016 PF01536 Adenosylmethionine decarboxylase 0.0016 PF02728 Copper amine oxidase, N3 domain 0.0016 PF02727 Copper amine oxidase, N2 domain 0.0016 PF01179 Copper amine oxidase, enzyme domain 0.0015 PF01916 Deoxyhypusine synthase 0.0015 PF00255 Glutathione peroxidase 0.0013 PF01808 AICARFT/IMPCHase bienzyme 0.0012 PF08919 F-actin binding 0.0007 PF00171 Aldehyde dehydrogenase family 0.0006 PF00018 SH3 domain 0.0006 PF00183 Hsp90 protein 0.0006 PF00375 Sodium:dicarboxylate symporter family 0.0004 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0004 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0004 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0004 PF00074 Pancreatic ribonuclease 0.0001 PF01590 GAF domain SUB840 CC1CC(C)CC1 0.1307 PF02159 Oestrogen receptor 0.1109 PF02155 Glucocorticoid receptor 0.1107 PF00191 Annexin 0.0965 PF00105 Zinc finger, C4 type (two domains), 0.0962 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0947 PF02161 Progesterone receptor 0.0724 PF02166 Androgen receptor 0.0519 PF01735 Lysophospholipase catalytic domain 0.0430 PF00079 Serpin (serine protease inhibitor), 0.0207 PF00168 C2 domain 0.0165 PF12497 Estrogen receptor beta 0.0134 PF08035 Opioids neuropeptide 0.0134 PF00976 Corticotropin ACTH domain 0.0134 PF08384 Pro-opiomelanocortin, N-terminal region 0.0108 PF00689 Cation transporting ATPase, C-terminus 0.0108 PF00690 Cation transporter/ATPase, N-terminus 0.0096 PF00122 E1-E2 ATPase 0.0081 PF00702 haloacid dehalogenase-like hydrolase 0.0072 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0072 PF07648 Kazal-type serine protease inhibitor domain 0.0072 PF00554 Rel homology domain (RHD), 0.0070 PF00031 Cystatin domain 0.0070 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0067 PF00212 Atrial natriuretic peptide 0.0060 PF08377 MAP2/Tau projection domain 0.0060 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0052 PF00067 Cytochrome P450 0.0050 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0048 PF01607 Chitin binding Peritrophin-A domain 0.0048 PF00704 Glycosyl hydrolases family 18 0.0046 PF00039 Fibronectin type I domain 0.0041 PF02898 Nitric oxide synthase, oxygenase domain 0.0037 PF00106 short chain dehydrogenase 0.0037 PF00531 Death domain 0.0036 PF00762 Ferrochelatase 0.0031 PF09164 Vitamin D binding protein, domain III 0.0031 PF00654 Voltage gated chloride channel 0.0030 PF02180 Bcl-2 homology region 4 0.0030 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0025 PF00667 FAD binding domain 0.0025 PF00258 Flavodoxin 0.0024 PF00305 Lipoxygenase 0.0021 PF00884 Sulfatase 0.0021 PF02038 ATP1G1/PLM/MAT8 family 0.0020 PF00432 Prenyltransferase and squalene oxidase repeat 0.0020 PF00175 Oxidoreductase NAD-binding domain 0.0019 PF07884 Vitamin K epoxide reductase family 0.0013 PF00023 Ankyrin repeat 0.0009 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0009 PF01477 PLAT/LH2 domain 0.0009 PF00969 Class II histocompatibility antigen, beta domain 0.0009 PF00341 Platelet-derived growth factor (PDGF), 0.0008 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0008 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0008 PF02210 Laminin G domain 0.0008 PF00377 Prion/Doppel alpha-helical domain 0.0008 PF04756 OST3 / OST6 family 0.0007 PF01593 Flavin containing amine oxidoreductase 0.0005 PF01429 Methyl-CpG binding domain 0.0005 PF00019 Transforming growth factor beta like domain 0.0005 PF00020 TNFR/NGFR cysteine-rich region 0.0005 PF00688 TGF-beta propeptide 0.0004 PF05193 Peptidase M16 inactive domain 0.0004 PF00675 Insulinase (Peptidase family M16), 0.0004 PF00714 Interferon gamma 0.0003 PF00340 Interleukin-1 / 18 0.0003 PF02394 Interleukin-1 propeptide 0.0002 PF01431 Peptidase family M13 0.0002 PF00656 Caspase domain 0.0002 PF05649 Peptidase family M13 0.0001 PF01391 Collagen triple helix repeat (20 copies), SUB500 N-C:C:N 0.1306 PF00227 Proteasome subunit 0.0181 PF01048 Phosphorylase superfamily 0.0177 PF01122 Eukaryotic cobalamin-binding protein 0.0156 PF00478 IMP dehydrogenase / GMP reductase domain 0.0156 PF00069 Protein kinase domain 0.0139 PF00186 Dihydrofolate reductase 0.0120 PF01642 Methylmalonyl-CoA mutase 0.0120 PF02310 B12 binding domain 0.0120 PF03308 ArgK protein 0.0120 PF01923 Cobalamin adenosyltransferase 0.0115 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0104 PF00571 CBS domain 0.0095 PF00962 Adenosine/AMP deaminase 0.0088 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0077 PF08240 Alcohol dehydrogenase GroES-like domain 0.0076 PF00156 Phosphoribosyl transferase domain 0.0074 PF00107 Zinc-binding dehydrogenase 0.0069 PF00106 short chain dehydrogenase 0.0064 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0062 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0062 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0058 PF01590 GAF domain 0.0057 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0057 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0057 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0054 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0050 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0050 PF02607 B12 binding domain 0.0050 PF00809 Pterin binding enzyme 0.0048 PF00858 Amiloride-sensitive sodium channel 0.0048 PF00431 CUB domain 0.0047 PF00171 Aldehyde dehydrogenase family 0.0046 PF00258 Flavodoxin 0.0046 PF00667 FAD binding domain 0.0045 PF00175 Oxidoreductase NAD-binding domain 0.0043 PF00017 SH2 domain 0.0042 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0042 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0042 PF01467 Cytidylyltransferase 0.0039 PF00018 SH3 domain 0.0036 PF02223 Thymidylate kinase 0.0034 PF01126 Heme oxygenase 0.0032 PF07645 Calcium-binding EGF domain 0.0031 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0031 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0031 PF00501 AMP-binding enzyme 0.0030 PF00970 Oxidoreductase FAD-binding domain 0.0029 PF01575 MaoC like domain 0.0029 PF02036 SCP-2 sterol transfer family 0.0029 PF01652 Eukaryotic initiation factor 4E 0.0028 PF08919 F-actin binding 0.0026 PF00498 FHA domain 0.0026 PF12473 Kinesin protein 0.0026 PF08676 MutL C terminal dimerisation domain 0.0026 PF01119 DNA mismatch repair protein, C-terminal domain 0.0026 PF12423 Kinesin protein 1B 0.0025 PF08996 DNA Polymerase alpha zinc finger 0.0025 PF03104 DNA polymerase family B, exonuclease domain 0.0025 PF02574 Homocysteine S-methyltransferase 0.0025 PF00136 DNA polymerase family B 0.0025 PF10397 Adenylosuccinate lyase C-terminus 0.0025 PF01230 HIT domain 0.0025 PF02233 NAD(P), transhydrogenase beta subunit 0.0024 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0024 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0024 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0024 PF00821 Phosphoenolpyruvate carboxykinase 0.0023 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0023 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0023 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0022 PF01808 AICARFT/IMPCHase bienzyme 0.0022 PF00225 Kinesin motor domain 0.0021 PF00931 NB-ARC domain 0.0021 PF02525 Flavodoxin-like fold 0.0021 PF00400 WD domain, G-beta repeat 0.0021 PF00248 Aldo/keto reductase family 0.0020 PF00676 Dehydrogenase E1 component 0.0020 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0020 PF03949 Malic enzyme, NAD binding domain 0.0020 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0020 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0020 PF02267 ADP-ribosyl cyclase 0.0020 PF07966 A1 Propeptide 0.0020 PF00390 Malic enzyme, N-terminal domain 0.0020 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0019 PF03770 Inositol polyphosphate kinase 0.0019 PF00071 Ras family 0.0019 PF00378 Enoyl-CoA hydratase/isomerase family 0.0019 PF00689 Cation transporting ATPase, C-terminus 0.0019 PF00690 Cation transporter/ATPase, N-terminus 0.0017 PF08515 Transforming growth factor beta type I GS-motif 0.0017 PF01064 Activin types I and II receptor domain 0.0017 PF00702 haloacid dehalogenase-like hydrolase 0.0016 PF02867 Ribonucleotide reductase, barrel domain 0.0016 PF00958 GMP synthase C terminal domain 0.0016 PF03477 ATP cone domain 0.0016 PF00317 Ribonucleotide reductase, all-alpha domain 0.0015 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0015 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0014 PF03073 TspO/MBR family 0.0014 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0013 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0013 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0013 PF00310 Glutamine amidotransferases class-II 0.0013 PF05347 Complex 1 protein (LYR family), 0.0012 PF00122 E1-E2 ATPase 0.0012 PF11555 EGFR receptor inhibitor Mig-6 0.0012 PF09027 GTPase binding 0.0011 PF03024 Folate receptor family 0.0011 PF04679 ATP dependent DNA ligase C terminal region 0.0011 PF01404 Ephrin receptor ligand binding domain 0.0011 PF00334 Nucleoside diphosphate kinase 0.0011 PF01268 Formate--tetrahydrofolate ligase 0.0011 PF00536 SAM domain (Sterile alpha motif), 0.0011 PF01068 ATP dependent DNA ligase domain 0.0011 PF00025 ADP-ribosylation factor family 0.0010 PF02779 Transketolase, pyrimidine binding domain 0.0010 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0010 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0009 PF01030 Receptor L domain 0.0009 PF00042 Globin 0.0009 PF00757 Furin-like cysteine rich region 0.0009 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0009 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0009 PF01712 Deoxynucleoside kinase 0.0008 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0008 PF00206 Lyase 0.0008 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0008 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0007 PF01687 Riboflavin kinase 0.0007 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0007 PF01916 Deoxyhypusine synthase 0.0007 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0007 PF05406 WGR domain 0.0007 PF00533 BRCA1 C Terminus (BRCT), domain 0.0007 PF00794 PI3-kinase family, ras-binding domain 0.0007 PF00792 Phosphoinositide 3-kinase C2 0.0007 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0007 PF08063 PADR1 (NUC008), domain 0.0007 PF01370 NAD dependent epimerase/dehydratase family 0.0006 PF03530 Calcium-activated SK potassium channel 0.0006 PF02888 Calmodulin binding domain 0.0006 PF00005 ABC transporter 0.0005 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0005 PF02772 S-adenosylmethionine synthetase, central domain 0.0005 PF00026 Eukaryotic aspartyl protease 0.0005 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0004 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0004 PF00183 Hsp90 protein 0.0004 PF08040 MNLL subunit 0.0004 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0004 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0004 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0004 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0004 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0004 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0004 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0004 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0004 PF02817 e3 binding domain 0.0004 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0004 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0004 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0004 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0004 PF10276 Zinc-finger domain 0.0004 PF09326 Domain of unknown function (DUF1982), 0.0004 PF00384 Molybdopterin oxidoreductase 0.0004 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0004 PF04716 ETC complex I subunit conserved region 0.0004 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0004 PF06212 GRIM-19 protein 0.0004 PF04116 Fatty acid hydroxylase superfamily 0.0004 PF00057 Low-density lipoprotein receptor domain class A 0.0004 PF00058 Low-density lipoprotein receptor repeat class B 0.0004 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0004 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0004 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0004 PF10531 SLBB domain 0.0004 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0004 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0004 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0004 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0004 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0004 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0004 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0004 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0004 PF04800 ETC complex I subunit conserved region 0.0004 PF09166 Biliverdin reductase, catalytic 0.0004 PF02466 Tim17/Tim22/Tim23 family 0.0004 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0004 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0004 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0003 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0003 PF01835 MG2 domain 0.0003 PF10509 Galactokinase galactose-binding signature 0.0003 PF00004 ATPase family associated with various cellular activities (AAA), 0.0003 PF00012 Hsp70 protein 0.0003 PF02493 MORN repeat 0.0003 PF02037 SAP domain 0.0003 PF00348 Polyprenyl synthetase 0.0003 PF01591 6-phosphofructo-2-kinase 0.0003 PF00316 Fructose-1-6-bisphosphatase 0.0003 PF01747 ATP-sulfurylase 0.0003 PF00287 Sodium / potassium ATPase beta chain 0.0003 PF00288 GHMP kinases N terminal domain 0.0003 PF00300 Phosphoglycerate mutase family 0.0003 PF00856 SET domain 0.0003 PF00899 ThiF family 0.0003 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0003 PF01583 Adenylylsulphate kinase 0.0003 PF01434 Peptidase family M41 0.0003 PF12062 heparan sulfate-N-deacetylase 0.0003 PF08544 GHMP kinases C terminal 0.0003 PF07677 A-macroglobulin receptor 0.0003 PF07678 A-macroglobulin complement component 0.0003 PF00629 MAM domain 0.0003 PF00439 Bromodomain 0.0003 PF02173 pKID domain 0.0003 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0003 PF00221 Phenylalanine and histidine ammonia-lyase 0.0002 PF01437 Plexin repeat 0.0002 PF01403 Sema domain 0.0002 PF00108 Thiolase, N-terminal domain 0.0002 PF00615 Regulator of G protein signaling domain 0.0002 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0002 PF01017 STAT protein, all-alpha domain 0.0002 PF02142 MGS-like domain 0.0002 PF01582 TIR domain 0.0002 PF00002 7 transmembrane receptor (Secretin family), 0.0002 PF02865 STAT protein, protein interaction domain 0.0002 PF02864 STAT protein, DNA binding domain 0.0002 PF01833 IPT/TIG domain 0.0002 PF00291 Pyridoxal-phosphate dependent enzyme 0.0002 PF02793 Hormone receptor domain 0.0002 PF02196 Raf-like Ras-binding domain 0.0002 PF00343 Carbohydrate phosphorylase 0.0002 PF02803 Thiolase, C-terminal domain 0.0001 PF00349 Hexokinase 0.0001 PF03727 Hexokinase 0.0001 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0001 PF00619 Caspase recruitment domain 0.0001 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0001 PF01061 ABC-2 type transporter SUB643 O-C-C-C=O 0.1293 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1293 PF08070 DTHCT (NUC029), region 0.1293 PF00204 DNA gyrase B 0.0587 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0161 PF00273 Serum albumin family 0.0147 PF03953 Tubulin C-terminal domain 0.0147 PF00091 Tubulin/FtsZ family, GTPase domain 0.0114 PF00102 Protein-tyrosine phosphatase 0.0110 PF00576 HIUase/Transthyretin family 0.0083 PF00405 Transferrin 0.0083 PF00005 ABC transporter 0.0082 PF09396 Thrombin light chain 0.0078 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0074 PF01061 ABC-2 type transporter 0.0060 PF07884 Vitamin K epoxide reductase family 0.0059 PF00664 ABC transporter transmembrane region 0.0055 PF00754 F5/8 type C domain 0.0052 PF00017 SH2 domain 0.0050 PF08919 F-actin binding 0.0048 PF03098 Animal haem peroxidase 0.0045 PF01735 Lysophospholipase catalytic domain 0.0044 PF00018 SH3 domain 0.0043 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0038 PF01187 Macrophage migration inhibitory factor (MIF), 0.0038 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0036 PF00305 Lipoxygenase 0.0035 PF03957 Jun-like transcription factor 0.0035 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0034 PF00079 Serpin (serine protease inhibitor), 0.0034 PF03171 2OG-Fe(II), oxygenase superfamily 0.0033 PF00291 Pyridoxal-phosphate dependent enzyme 0.0032 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0030 PF01477 PLAT/LH2 domain 0.0030 PF00266 Aminotransferase class-V 0.0030 PF00656 Caspase domain 0.0029 PF03949 Malic enzyme, NAD binding domain 0.0029 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0029 PF00390 Malic enzyme, N-terminal domain 0.0028 PF02259 FAT domain 0.0028 PF02155 Glucocorticoid receptor 0.0028 PF00043 Glutathione S-transferase, C-terminal domain 0.0028 PF00168 C2 domain 0.0028 PF02260 FATC domain 0.0028 PF08771 Rapamycin binding domain 0.0027 PF02798 Glutathione S-transferase, N-terminal domain 0.0026 PF00493 MCM2/3/5 family 0.0026 PF00229 TNF(Tumour Necrosis Factor), family 0.0026 PF02394 Interleukin-1 propeptide 0.0026 PF00340 Interleukin-1 / 18 0.0024 PF00341 Platelet-derived growth factor (PDGF), 0.0024 PF01347 Lipoprotein amino terminal region 0.0024 PF01023 S-100/ICaBP type calcium binding domain 0.0023 PF01180 Dihydroorotate dehydrogenase 0.0022 PF00155 Aminotransferase class I and II 0.0022 PF02803 Thiolase, C-terminal domain 0.0022 PF00108 Thiolase, N-terminal domain 0.0021 PF00040 Fibronectin type II domain 0.0021 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0021 PF00271 Helicase conserved C-terminal domain 0.0021 PF00698 Acyl transferase domain 0.0021 PF08659 KR domain 0.0021 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0021 PF00975 Thioesterase domain 0.0021 PF00377 Prion/Doppel alpha-helical domain 0.0021 PF00989 PAS fold 0.0020 PF00071 Ras family 0.0020 PF00085 Thioredoxin 0.0020 PF00170 bZIP transcription factor 0.0020 PF01202 Shikimate kinase 0.0019 PF02793 Hormone receptor domain 0.0019 PF06448 Domain of Unknown Function (DUF1081), 0.0019 PF00191 Annexin 0.0019 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0019 PF00002 7 transmembrane receptor (Secretin family), 0.0019 PF12491 Apolipoprotein B100 C terminal 0.0019 PF02059 Interleukin-3 0.0018 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0018 PF00176 SNF2 family N-terminal domain 0.0017 PF01391 Collagen triple helix repeat (20 copies), 0.0017 PF00755 Choline/Carnitine o-acyltransferase 0.0016 PF00027 Cyclic nucleotide-binding domain 0.0016 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0016 PF02525 Flavodoxin-like fold 0.0016 PF03062 MBOAT family 0.0015 PF02025 Interleukin 5 0.0015 PF00058 Low-density lipoprotein receptor repeat class B 0.0015 PF00609 Diacylglycerol kinase accessory domain 0.0015 PF00094 von Willebrand factor type D domain 0.0015 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0015 PF02180 Bcl-2 homology region 4 0.0015 PF04679 ATP dependent DNA ligase C terminal region 0.0015 PF03034 Phosphatidyl serine synthase 0.0015 PF02824 TGS domain 0.0015 PF08742 C8 domain 0.0015 PF00781 Diacylglycerol kinase catalytic domain 0.0015 PF01731 Arylesterase 0.0015 PF01068 ATP dependent DNA ligase domain 0.0015 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0014 PF02375 jmjN domain 0.0014 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0014 PF02928 C5HC2 zinc finger 0.0014 PF00860 Permease family 0.0014 PF02373 JmjC domain 0.0014 PF08429 PLU-1-like protein 0.0014 PF01753 MYND finger 0.0014 PF00183 Hsp90 protein 0.0014 PF00342 Phosphoglucose isomerase 0.0014 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0014 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0014 PF01388 ARID/BRIGHT DNA binding domain 0.0014 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0014 PF00628 PHD-finger 0.0014 PF00274 Fructose-bisphosphate aldolase class-I 0.0013 PF00057 Low-density lipoprotein receptor domain class A 0.0013 PF01596 O-methyltransferase 0.0013 PF00464 Serine hydroxymethyltransferase 0.0012 PF03476 MOSC N-terminal beta barrel domain 0.0012 PF03473 MOSC domain 0.0012 PF00654 Voltage gated chloride channel 0.0012 PF01429 Methyl-CpG binding domain 0.0012 PF01425 Amidase 0.0012 PF00343 Carbohydrate phosphorylase 0.0012 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0011 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0011 PF00717 Peptidase S24-like 0.0011 PF01437 Plexin repeat 0.0011 PF01833 IPT/TIG domain 0.0011 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0011 PF03351 DOMON domain 0.0011 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0011 PF00186 Dihydrofolate reductase 0.0011 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0011 PF01403 Sema domain 0.0010 PF11404 Potassium voltage-gated channel 0.0010 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0010 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0010 PF00270 DEAD/DEAH box helicase 0.0010 PF01130 CD36 family 0.0010 PF09193 Cholecystokinin A receptor, N-terminal 0.0010 PF02666 Phosphatidylserine decarboxylase 0.0010 PF07647 SAM domain (Sterile alpha motif), 0.0010 PF00550 Phosphopantetheine attachment site 0.0010 PF02403 Seryl-tRNA synthetase N-terminal domain 0.0010 PF00554 Rel homology domain (RHD), 0.0010 PF00969 Class II histocompatibility antigen, beta domain 0.0010 PF00246 Zinc carboxypeptidase 0.0009 PF03623 Focal adhesion targeting region 0.0009 PF02898 Nitric oxide synthase, oxygenase domain 0.0009 PF00051 Kringle domain 0.0008 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0008 PF00294 pfkB family carbohydrate kinase 0.0008 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0008 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.0008 PF03360 Glycosyltransferase family 43 0.0007 PF02347 Glycine cleavage system P-protein 0.0007 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0007 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 0.0007 PF01212 Beta-eliminating lyase 0.0007 PF01168 Alanine racemase, N-terminal domain 0.0007 PF07690 Major Facilitator Superfamily 0.0006 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0006 PF00714 Interferon gamma 0.0006 PF00028 Cadherin domain 0.0006 PF00020 TNFR/NGFR cysteine-rich region 0.0006 PF00019 Transforming growth factor beta like domain 0.0006 PF00688 TGF-beta propeptide 0.0006 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0006 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0006 PF00489 Interleukin-6/G-CSF/MGF family 0.0006 PF00373 FERM central domain 0.0006 PF00151 Lipase 0.0005 PF00682 HMGL-like 0.0005 PF00202 Aminotransferase class-III 0.0004 PF08063 PADR1 (NUC008), domain 0.0004 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0004 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0004 PF05406 WGR domain 0.0004 PF00619 Caspase recruitment domain 0.0004 PF00533 BRCA1 C Terminus (BRCT), domain 0.0004 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0004 PF01462 Leucine rich repeat N-terminal domain 0.0003 PF01067 Calpain large subunit, domain III 0.0003 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0003 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0003 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0003 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0003 PF00024 PAN domain 0.0003 PF00622 SPRY domain 0.0003 PF00432 Prenyltransferase and squalene oxidase repeat 0.0003 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0003 PF04961 Formiminotransferase-cyclodeaminase 0.0003 PF00787 PX domain 0.0003 PF00648 Calpain family cysteine protease 0.0003 PF02971 Formiminotransferase domain 0.0003 PF02460 Patched family 0.0003 PF00571 CBS domain 0.0003 PF03129 Anticodon binding domain 0.0003 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0003 PF00792 Phosphoinositide 3-kinase C2 0.0003 PF00794 PI3-kinase family, ras-binding domain 0.0002 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0002 PF02210 Laminin G domain 0.0002 PF06459 Ryanodine Receptor TM 4-6 0.0002 PF07648 Kazal-type serine protease inhibitor domain 0.0002 PF00354 Pentaxin family 0.0002 PF02815 MIR domain 0.0002 PF08709 Inositol 1,4,5-trisphosphate/ryanodine receptor 0.0002 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0002 PF00433 Protein kinase C terminal domain 0.0002 PF00074 Pancreatic ribonuclease 0.0002 PF02758 PAAD/DAPIN/Pyrin domain 0.0002 PF00025 ADP-ribosylation factor family 0.0002 PF00227 Proteasome subunit 0.0002 PF01365 RIH domain 0.0002 PF02026 RyR domain 0.0002 PF08454 RyR and IP3R Homology associated 0.0002 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0002 PF04756 OST3 / OST6 family 0.0002 PF03024 Folate receptor family 0.0001 PF00067 Cytochrome P450 0.0001 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0001 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0001 PF00531 Death domain 0.0001 PF08725 Integrin beta cytoplasmic domain 0.0001 PF00089 Trypsin SUB582 O=C-C-C-O 0.1293 PF00204 DNA gyrase B 0.1293 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1293 PF08070 DTHCT (NUC029), region 0.0587 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0161 PF00273 Serum albumin family 0.0147 PF03953 Tubulin C-terminal domain 0.0147 PF00091 Tubulin/FtsZ family, GTPase domain 0.0114 PF00102 Protein-tyrosine phosphatase 0.0110 PF00576 HIUase/Transthyretin family 0.0083 PF00405 Transferrin 0.0083 PF00005 ABC transporter 0.0082 PF09396 Thrombin light chain 0.0078 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0074 PF01061 ABC-2 type transporter 0.0060 PF07884 Vitamin K epoxide reductase family 0.0059 PF00664 ABC transporter transmembrane region 0.0055 PF00754 F5/8 type C domain 0.0052 PF00017 SH2 domain 0.0050 PF08919 F-actin binding 0.0048 PF03098 Animal haem peroxidase 0.0045 PF01735 Lysophospholipase catalytic domain 0.0044 PF00018 SH3 domain 0.0043 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0038 PF01187 Macrophage migration inhibitory factor (MIF), 0.0038 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0036 PF00305 Lipoxygenase 0.0035 PF03957 Jun-like transcription factor 0.0035 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0034 PF00079 Serpin (serine protease inhibitor), 0.0034 PF03171 2OG-Fe(II), oxygenase superfamily 0.0033 PF00291 Pyridoxal-phosphate dependent enzyme 0.0032 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0030 PF00656 Caspase domain 0.0030 PF01477 PLAT/LH2 domain 0.0030 PF00266 Aminotransferase class-V 0.0029 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0029 PF03949 Malic enzyme, NAD binding domain 0.0029 PF00390 Malic enzyme, N-terminal domain 0.0028 PF02260 FATC domain 0.0028 PF00168 C2 domain 0.0028 PF08771 Rapamycin binding domain 0.0028 PF02259 FAT domain 0.0028 PF02155 Glucocorticoid receptor 0.0028 PF00043 Glutathione S-transferase, C-terminal domain 0.0027 PF02798 Glutathione S-transferase, N-terminal domain 0.0026 PF00229 TNF(Tumour Necrosis Factor), family 0.0026 PF02394 Interleukin-1 propeptide 0.0026 PF00340 Interleukin-1 / 18 0.0026 PF00493 MCM2/3/5 family 0.0024 PF00341 Platelet-derived growth factor (PDGF), 0.0024 PF01023 S-100/ICaBP type calcium binding domain 0.0024 PF01347 Lipoprotein amino terminal region 0.0023 PF01180 Dihydroorotate dehydrogenase 0.0022 PF00155 Aminotransferase class I and II 0.0022 PF00108 Thiolase, N-terminal domain 0.0022 PF02803 Thiolase, C-terminal domain 0.0021 PF00698 Acyl transferase domain 0.0021 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0021 PF00040 Fibronectin type II domain 0.0021 PF00975 Thioesterase domain 0.0021 PF00989 PAS fold 0.0021 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0021 PF08659 KR domain 0.0021 PF00271 Helicase conserved C-terminal domain 0.0021 PF00377 Prion/Doppel alpha-helical domain 0.0020 PF00170 bZIP transcription factor 0.0020 PF01202 Shikimate kinase 0.0020 PF00071 Ras family 0.0020 PF00085 Thioredoxin 0.0019 PF06448 Domain of Unknown Function (DUF1081), 0.0019 PF00002 7 transmembrane receptor (Secretin family), 0.0019 PF02059 Interleukin-3 0.0019 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0019 PF12491 Apolipoprotein B100 C terminal 0.0019 PF00191 Annexin 0.0019 PF02793 Hormone receptor domain 0.0018 PF00176 SNF2 family N-terminal domain 0.0018 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0017 PF00755 Choline/Carnitine o-acyltransferase 0.0017 PF01391 Collagen triple helix repeat (20 copies), 0.0016 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0016 PF03062 MBOAT family 0.0016 PF02525 Flavodoxin-like fold 0.0016 PF00027 Cyclic nucleotide-binding domain 0.0015 PF02824 TGS domain 0.0015 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0015 PF00094 von Willebrand factor type D domain 0.0015 PF02180 Bcl-2 homology region 4 0.0015 PF04679 ATP dependent DNA ligase C terminal region 0.0015 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0015 PF03034 Phosphatidyl serine synthase 0.0015 PF01068 ATP dependent DNA ligase domain 0.0015 PF00609 Diacylglycerol kinase accessory domain 0.0015 PF00058 Low-density lipoprotein receptor repeat class B 0.0015 PF02025 Interleukin 5 0.0015 PF08742 C8 domain 0.0015 PF01731 Arylesterase 0.0015 PF00781 Diacylglycerol kinase catalytic domain 0.0014 PF00860 Permease family 0.0014 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0014 PF08429 PLU-1-like protein 0.0014 PF02375 jmjN domain 0.0014 PF02373 JmjC domain 0.0014 PF00183 Hsp90 protein 0.0014 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0014 PF01753 MYND finger 0.0014 PF00628 PHD-finger 0.0014 PF00342 Phosphoglucose isomerase 0.0014 PF00274 Fructose-bisphosphate aldolase class-I 0.0014 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0014 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0014 PF01388 ARID/BRIGHT DNA binding domain 0.0014 PF02928 C5HC2 zinc finger 0.0013 PF01596 O-methyltransferase 0.0013 PF00057 Low-density lipoprotein receptor domain class A 0.0013 PF00464 Serine hydroxymethyltransferase 0.0012 PF01429 Methyl-CpG binding domain 0.0012 PF01425 Amidase 0.0012 PF00343 Carbohydrate phosphorylase 0.0012 PF00654 Voltage gated chloride channel 0.0012 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0012 PF03476 MOSC N-terminal beta barrel domain 0.0012 PF03473 MOSC domain 0.0011 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0011 PF01833 IPT/TIG domain 0.0011 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0011 PF01437 Plexin repeat 0.0011 PF03351 DOMON domain 0.0011 PF01403 Sema domain 0.0011 PF00186 Dihydrofolate reductase 0.0011 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0011 PF00717 Peptidase S24-like 0.0011 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0010 PF00969 Class II histocompatibility antigen, beta domain 0.0010 PF00270 DEAD/DEAH box helicase 0.0010 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0010 PF02403 Seryl-tRNA synthetase N-terminal domain 0.0010 PF01130 CD36 family 0.0010 PF00550 Phosphopantetheine attachment site 0.0010 PF00554 Rel homology domain (RHD), 0.0010 PF00246 Zinc carboxypeptidase 0.0010 PF09193 Cholecystokinin A receptor, N-terminal 0.0010 PF07647 SAM domain (Sterile alpha motif), 0.0010 PF02666 Phosphatidylserine decarboxylase 0.0010 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0010 PF11404 Potassium voltage-gated channel 0.0009 PF03623 Focal adhesion targeting region 0.0009 PF02898 Nitric oxide synthase, oxygenase domain 0.0009 PF00051 Kringle domain 0.0008 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0008 PF00294 pfkB family carbohydrate kinase 0.0008 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.0008 PF03360 Glycosyltransferase family 43 0.0008 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0007 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 0.0007 PF01212 Beta-eliminating lyase 0.0007 PF07690 Major Facilitator Superfamily 0.0007 PF02347 Glycine cleavage system P-protein 0.0007 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0007 PF01168 Alanine racemase, N-terminal domain 0.0006 PF00028 Cadherin domain 0.0006 PF00020 TNFR/NGFR cysteine-rich region 0.0006 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0006 PF00489 Interleukin-6/G-CSF/MGF family 0.0006 PF00714 Interferon gamma 0.0006 PF00688 TGF-beta propeptide 0.0006 PF00151 Lipase 0.0006 PF00019 Transforming growth factor beta like domain 0.0006 PF00373 FERM central domain 0.0006 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0006 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0005 PF00682 HMGL-like 0.0005 PF00202 Aminotransferase class-III 0.0004 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0004 PF00619 Caspase recruitment domain 0.0004 PF01462 Leucine rich repeat N-terminal domain 0.0004 PF08063 PADR1 (NUC008), domain 0.0004 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0004 PF00533 BRCA1 C Terminus (BRCT), domain 0.0004 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0004 PF05406 WGR domain 0.0003 PF00787 PX domain 0.0003 PF00794 PI3-kinase family, ras-binding domain 0.0003 PF00792 Phosphoinositide 3-kinase C2 0.0003 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0003 PF01067 Calpain large subunit, domain III 0.0003 PF02971 Formiminotransferase domain 0.0003 PF00571 CBS domain 0.0003 PF00622 SPRY domain 0.0003 PF04961 Formiminotransferase-cyclodeaminase 0.0003 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0003 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0003 PF02460 Patched family 0.0003 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0003 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0003 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0003 PF00432 Prenyltransferase and squalene oxidase repeat 0.0003 PF03129 Anticodon binding domain 0.0003 PF00024 PAN domain 0.0003 PF00648 Calpain family cysteine protease 0.0002 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0002 PF00025 ADP-ribosylation factor family 0.0002 PF00433 Protein kinase C terminal domain 0.0002 PF08709 Inositol 1,4,5-trisphosphate/ryanodine receptor 0.0002 PF01365 RIH domain 0.0002 PF02210 Laminin G domain 0.0002 PF02815 MIR domain 0.0002 PF08454 RyR and IP3R Homology associated 0.0002 PF04756 OST3 / OST6 family 0.0002 PF02758 PAAD/DAPIN/Pyrin domain 0.0002 PF06459 Ryanodine Receptor TM 4-6 0.0002 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0002 PF00074 Pancreatic ribonuclease 0.0002 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0002 PF00227 Proteasome subunit 0.0002 PF00354 Pentaxin family 0.0002 PF07648 Kazal-type serine protease inhibitor domain 0.0002 PF02026 RyR domain 0.0002 PF03024 Folate receptor family 0.0001 PF00531 Death domain 0.0001 PF00067 Cytochrome P450 0.0001 PF00089 Trypsin 0.0001 PF08725 Integrin beta cytoplasmic domain 0.0001 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0001 PF03522 K-Cl Co-transporter type 1 (KCC1), SUB333 C(~C)(~C) 0.1292 PF00001 7 transmembrane receptor (rhodopsin family), 0.0721 PF00105 Zinc finger, C4 type (two domains), 0.0717 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0677 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0633 PF02159 Oestrogen receptor 0.0411 PF00209 Sodium:neurotransmitter symporter family 0.0284 PF03098 Animal haem peroxidase 0.0266 PF00204 DNA gyrase B 0.0266 PF08070 DTHCT (NUC029), region 0.0266 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0136 PF00091 Tubulin/FtsZ family, GTPase domain 0.0136 PF03953 Tubulin C-terminal domain 0.0135 PF00989 PAS fold 0.0111 PF09396 Thrombin light chain 0.0107 PF00027 Cyclic nucleotide-binding domain 0.0106 PF00005 ABC transporter 0.0096 PF00067 Cytochrome P450 0.0090 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0090 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0075 PF00664 ABC transporter transmembrane region 0.0039 PF02161 Progesterone receptor 0.0039 PF00273 Serum albumin family 0.0034 PF01593 Flavin containing amine oxidoreductase 0.0029 PF03073 TspO/MBR family 0.0024 PF12497 Estrogen receptor beta 0.0022 PF11825 Protein of unknown function (DUF3345), 0.0018 PF02166 Androgen receptor 0.0008 PF00061 Lipocalin / cytosolic fatty-acid binding protein family SUB693 O=C-C-C-C-C-C 0.1290 PF03098 Animal haem peroxidase 0.1287 PF00204 DNA gyrase B 0.1287 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1287 PF08070 DTHCT (NUC029), region 0.0732 PF00191 Annexin 0.0642 PF02155 Glucocorticoid receptor 0.0602 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0543 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0539 PF00105 Zinc finger, C4 type (two domains), 0.0530 PF00273 Serum albumin family 0.0460 PF00102 Protein-tyrosine phosphatase 0.0363 PF07884 Vitamin K epoxide reductase family 0.0242 PF01735 Lysophospholipase catalytic domain 0.0227 PF00005 ABC transporter 0.0215 PF06512 Sodium ion transport-associated 0.0204 PF02161 Progesterone receptor 0.0181 PF02525 Flavodoxin-like fold 0.0171 PF00576 HIUase/Transthyretin family 0.0168 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0166 PF00079 Serpin (serine protease inhibitor), 0.0164 PF01268 Formate--tetrahydrofolate ligase 0.0160 PF00464 Serine hydroxymethyltransferase 0.0159 PF02166 Androgen receptor 0.0157 PF00664 ABC transporter transmembrane region 0.0150 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0150 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0149 PF09396 Thrombin light chain 0.0128 PF00089 Trypsin 0.0128 PF00051 Kringle domain 0.0114 PF00554 Rel homology domain (RHD), 0.0109 PF00533 BRCA1 C Terminus (BRCT), domain 0.0109 PF05406 WGR domain 0.0109 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0109 PF08063 PADR1 (NUC008), domain 0.0109 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0097 PF01061 ABC-2 type transporter 0.0095 PF08403 Amino acid permease N-terminal 0.0094 PF00551 Formyl transferase 0.0087 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0084 PF11825 Protein of unknown function (DUF3345), 0.0081 PF00017 SH2 domain 0.0073 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0073 PF01571 Aminomethyltransferase folate-binding domain 0.0050 PF00018 SH3 domain 0.0048 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0048 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0048 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0042 PF02219 Methylenetetrahydrofolate reductase 0.0040 PF00531 Death domain 0.0038 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0027 PF00183 Hsp90 protein 0.0027 PF00229 TNF(Tumour Necrosis Factor), family 0.0019 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0016 PF01467 Cytidylyltransferase 0.0012 PF02911 Formyl transferase, C-terminal domain 0.0012 PF00343 Carbohydrate phosphorylase 0.0012 PF03024 Folate receptor family 0.0008 PF00248 Aldo/keto reductase family 0.0002 PF01180 Dihydroorotate dehydrogenase SUB350 C(~C)(~H)(~S) 0.1286 PF02798 Glutathione S-transferase, N-terminal domain 0.1257 PF00043 Glutathione S-transferase, C-terminal domain 0.0761 PF00255 Glutathione peroxidase 0.0613 PF05649 Peptidase family M13 0.0613 PF01431 Peptidase family M13 0.0534 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0430 PF01124 MAPEG family 0.0399 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0379 PF00091 Tubulin/FtsZ family, GTPase domain 0.0379 PF03953 Tubulin C-terminal domain 0.0369 PF01401 Angiotensin-converting enzyme 0.0349 PF09396 Thrombin light chain 0.0337 PF03199 Eukaryotic glutathione synthase 0.0337 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0259 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0256 PF01323 DSBA-like thioredoxin domain 0.0232 PF00656 Caspase domain 0.0227 PF08983 Domain of unknown function (DUF1856), 0.0215 PF00303 Thymidylate synthase 0.0200 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0188 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0186 PF00462 Glutaredoxin 0.0176 PF07722 Peptidase C26 0.0154 PF01406 tRNA synthetases class I (C), catalytic domain 0.0148 PF05995 Cysteine dioxygenase type I 0.0147 PF00756 Putative esterase 0.0147 PF01019 Gamma-glutamyltranspeptidase 0.0131 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0131 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0126 PF00619 Caspase recruitment domain 0.0122 PF03074 Glutamate-cysteine ligase 0.0085 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0084 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0084 PF00439 Bromodomain 0.0075 PF00581 Rhodanese-like domain 0.0075 PF06617 M-phase inducer phosphatase 0.0067 PF03002 Somatostatin/Cortistatin family 0.0066 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0064 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0057 PF00085 Thioredoxin 0.0056 PF00778 DIX domain 0.0056 PF08833 Axin beta-catenin binding domain 0.0056 PF00806 Pumilio-family RNA binding repeat 0.0054 PF00822 PMP-22/EMP/MP20/Claudin family 0.0050 PF00265 Thymidine kinase 0.0048 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0048 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0041 PF00342 Phosphoglucose isomerase 0.0040 PF00931 NB-ARC domain 0.0040 PF00400 WD domain, G-beta repeat 0.0030 PF02793 Hormone receptor domain 0.0030 PF00002 7 transmembrane receptor (Secretin family), 0.0022 PF01268 Formate--tetrahydrofolate ligase 0.0013 PF02769 AIR synthase related protein, C-terminal domain 0.0013 PF00586 AIR synthase related protein, N-terminal domain 0.0012 PF10420 Cytokine interleukin-12p40 C-terminus 0.0010 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0010 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0007 PF00045 Hemopexin 0.0007 PF00108 Thiolase, N-terminal domain 0.0007 PF01471 Putative peptidoglycan binding domain 0.0007 PF02803 Thiolase, C-terminal domain 0.0002 PF00551 Formyl transferase SUB447 C(-H)(=C) 0.1276 PF00001 7 transmembrane receptor (rhodopsin family), 0.1069 PF02159 Oestrogen receptor 0.0897 PF00105 Zinc finger, C4 type (two domains), 0.0893 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0710 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0550 PF00204 DNA gyrase B 0.0550 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0550 PF08070 DTHCT (NUC029), region 0.0461 PF00209 Sodium:neurotransmitter symporter family 0.0378 PF03098 Animal haem peroxidase 0.0315 PF06512 Sodium ion transport-associated 0.0289 PF02161 Progesterone receptor 0.0270 PF00191 Annexin 0.0258 PF09396 Thrombin light chain 0.0237 PF00520 Ion transport protein 0.0202 PF02155 Glucocorticoid receptor 0.0195 PF00989 PAS fold 0.0170 PF03073 TspO/MBR family 0.0154 PF00067 Cytochrome P450 0.0146 PF00027 Cyclic nucleotide-binding domain 0.0137 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0135 PF02166 Androgen receptor 0.0095 PF03953 Tubulin C-terminal domain 0.0095 PF00091 Tubulin/FtsZ family, GTPase domain 0.0075 PF01735 Lysophospholipase catalytic domain 0.0072 PF00102 Protein-tyrosine phosphatase 0.0072 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0072 PF00005 ABC transporter 0.0066 PF12497 Estrogen receptor beta 0.0051 PF00186 Dihydrofolate reductase 0.0042 PF00305 Lipoxygenase 0.0042 PF00664 ABC transporter transmembrane region 0.0005 PF07884 Vitamin K epoxide reductase family SUB575 O-C-C:C-C 0.1255 PF02159 Oestrogen receptor 0.0663 PF00001 7 transmembrane receptor (rhodopsin family), 0.0543 PF00105 Zinc finger, C4 type (two domains), 0.0530 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0507 PF08070 DTHCT (NUC029), region 0.0507 PF00204 DNA gyrase B 0.0507 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0253 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0246 PF12497 Estrogen receptor beta 0.0245 PF00576 HIUase/Transthyretin family 0.0197 PF08384 Pro-opiomelanocortin, N-terminal region 0.0197 PF00976 Corticotropin ACTH domain 0.0197 PF08035 Opioids neuropeptide 0.0189 PF00102 Protein-tyrosine phosphatase 0.0185 PF00989 PAS fold 0.0183 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0151 PF00027 Cyclic nucleotide-binding domain 0.0147 PF00005 ABC transporter 0.0145 PF00664 ABC transporter transmembrane region 0.0123 PF11825 Protein of unknown function (DUF3345), 0.0103 PF00643 B-box zinc finger 0.0095 PF01596 O-methyltransferase 0.0070 PF01477 PLAT/LH2 domain 0.0069 PF00305 Lipoxygenase 0.0066 PF00340 Interleukin-1 / 18 0.0066 PF02394 Interleukin-1 propeptide 0.0066 PF03062 MBOAT family 0.0055 PF08983 Domain of unknown function (DUF1856), 0.0039 PF04622 ERG2 and Sigma1 receptor like protein 0.0035 PF00656 Caspase domain 0.0035 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0034 PF00918 Gastrin/cholecystokinin family 0.0034 PF01160 Vertebrate endogenous opioids neuropeptide 0.0034 PF00183 Hsp90 protein 0.0023 PF01588 Putative tRNA binding domain 0.0023 PF01180 Dihydroorotate dehydrogenase 0.0022 PF00135 Carboxylesterase 0.0022 PF03765 CRAL/TRIO, N-terminus 0.0022 PF02180 Bcl-2 homology region 4 0.0022 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0022 PF00650 CRAL/TRIO domain 0.0022 PF08377 MAP2/Tau projection domain 0.0022 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0021 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0021 PF02460 Patched family 0.0020 PF00377 Prion/Doppel alpha-helical domain 0.0020 PF08441 Integrin alpha 0.0019 PF06327 Domain of Unknown Function (DUF1053), 0.0019 PF00884 Sulfatase 0.0018 PF00625 Guanylate kinase 0.0016 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0016 PF00357 Integrin alpha cytoplasmic region 0.0013 PF09396 Thrombin light chain 0.0013 PF07885 Ion channel 0.0011 PF00229 TNF(Tumour Necrosis Factor), family 0.0010 PF00341 Platelet-derived growth factor (PDGF), 0.0009 PF00002 7 transmembrane receptor (Secretin family), 0.0009 PF08763 Voltage gated calcium channel IQ domain 0.0009 PF02793 Hormone receptor domain 0.0008 PF09193 Cholecystokinin A receptor, N-terminal 0.0008 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0008 PF00094 von Willebrand factor type D domain 0.0008 PF08742 C8 domain 0.0008 PF00641 Zn-finger in Ran binding protein and others 0.0008 PF02025 Interleukin 5 0.0008 PF02201 SWIB/MDM2 domain 0.0007 PF00068 Phospholipase A2 0.0007 PF00170 bZIP transcription factor 0.0006 PF01030 Receptor L domain 0.0006 PF00091 Tubulin/FtsZ family, GTPase domain 0.0006 PF03953 Tubulin C-terminal domain 0.0006 PF00757 Furin-like cysteine rich region 0.0005 PF01733 Nucleoside transporter 0.0005 PF02173 pKID domain 0.0005 PF00266 Aminotransferase class-V 0.0005 PF00620 RhoGAP domain 0.0004 PF01347 Lipoprotein amino terminal region 0.0003 PF00151 Lipase SUB614 C-N-C-C-C 0.1252 PF00001 7 transmembrane receptor (rhodopsin family), 0.0499 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0413 PF00209 Sodium:neurotransmitter symporter family 0.0297 PF03073 TspO/MBR family 0.0244 PF01401 Angiotensin-converting enzyme 0.0177 PF00005 ABC transporter 0.0152 PF00664 ABC transporter transmembrane region 0.0145 PF00989 PAS fold 0.0128 PF00186 Dihydrofolate reductase 0.0122 PF00027 Cyclic nucleotide-binding domain 0.0120 PF02223 Thymidylate kinase 0.0103 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0099 PF01048 Phosphorylase superfamily 0.0084 PF00069 Protein kinase domain 0.0080 PF06512 Sodium ion transport-associated 0.0074 PF01431 Peptidase family M13 0.0074 PF05649 Peptidase family M13 0.0063 PF00520 Ion transport protein 0.0057 PF00017 SH2 domain 0.0056 PF02180 Bcl-2 homology region 4 0.0056 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0051 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0051 PF02267 ADP-ribosyl cyclase 0.0051 PF08983 Domain of unknown function (DUF1856), 0.0045 PF01007 Inward rectifier potassium channel 0.0032 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0029 PF01842 ACT domain 0.0029 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0028 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0028 PF00464 Serine hydroxymethyltransferase 0.0024 PF01061 ABC-2 type transporter 0.0023 PF00255 Glutathione peroxidase 0.0023 PF01467 Cytidylyltransferase 0.0023 PF00018 SH3 domain 0.0022 PF00303 Thymidylate synthase 0.0022 PF02798 Glutathione S-transferase, N-terminal domain 0.0020 PF01234 NNMT/PNMT/TEMT family 0.0020 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0020 PF08919 F-actin binding 0.0020 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0017 PF00043 Glutathione S-transferase, C-terminal domain 0.0017 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0017 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0014 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0012 PF01590 GAF domain 0.0011 PF00551 Formyl transferase 0.0011 PF03807 NADP oxidoreductase coenzyme F420-dependent 0.0010 PF08491 Squalene epoxidase 0.0007 PF00088 Trefoil (P-type), domain 0.0007 PF08441 Integrin alpha 0.0007 PF01055 Glycosyl hydrolases family 31 0.0006 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0006 PF09396 Thrombin light chain 0.0005 PF01808 AICARFT/IMPCHase bienzyme 0.0005 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0005 PF05406 WGR domain 0.0005 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0005 PF02173 pKID domain 0.0005 PF07966 A1 Propeptide 0.0005 PF01687 Riboflavin kinase 0.0005 PF08063 PADR1 (NUC008), domain 0.0005 PF00533 BRCA1 C Terminus (BRCT), domain 0.0005 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0004 PF00357 Integrin alpha cytoplasmic region 0.0004 PF08403 Amino acid permease N-terminal 0.0004 PF06464 DMAP1-binding Domain 0.0004 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0004 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0004 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0004 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0004 PF02008 CXXC zinc finger domain 0.0004 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0004 PF01571 Aminomethyltransferase folate-binding domain 0.0004 PF00026 Eukaryotic aspartyl protease 0.0004 PF01122 Eukaryotic cobalamin-binding protein 0.0004 PF01426 BAH domain 0.0002 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0002 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0001 PF00204 DNA gyrase B 0.0001 PF01268 Formate--tetrahydrofolate ligase 0.0001 PF08070 DTHCT (NUC029), region 0.0001 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0001 PF00755 Choline/Carnitine o-acyltransferase 0.0001 PF00521 DNA gyrase/topoisomerase IV, subunit A SUB553 C:C-C:C 0.1245 PF00001 7 transmembrane receptor (rhodopsin family), 0.0583 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0415 PF00209 Sodium:neurotransmitter symporter family 0.0370 PF03098 Animal haem peroxidase 0.0315 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0315 PF00204 DNA gyrase B 0.0315 PF08070 DTHCT (NUC029), region 0.0300 PF00194 Eukaryotic-type carbonic anhydrase 0.0280 PF06512 Sodium ion transport-associated 0.0236 PF03073 TspO/MBR family 0.0235 PF00520 Ion transport protein 0.0148 PF00989 PAS fold 0.0122 PF00027 Cyclic nucleotide-binding domain 0.0122 PF09396 Thrombin light chain 0.0119 PF00102 Protein-tyrosine phosphatase 0.0112 PF00186 Dihydrofolate reductase 0.0095 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0090 PF01593 Flavin containing amine oxidoreductase 0.0086 PF00576 HIUase/Transthyretin family 0.0081 PF00005 ABC transporter 0.0069 PF08403 Amino acid permease N-terminal 0.0065 PF01007 Inward rectifier potassium channel 0.0054 PF00664 ABC transporter transmembrane region 0.0049 PF00069 Protein kinase domain 0.0048 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0032 PF05649 Peptidase family M13 0.0032 PF01431 Peptidase family M13 0.0032 PF00017 SH2 domain 0.0030 PF07884 Vitamin K epoxide reductase family 0.0022 PF02254 TrkA-N domain 0.0022 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0021 PF01401 Angiotensin-converting enzyme 0.0019 PF00018 SH3 domain 0.0014 PF00822 PMP-22/EMP/MP20/Claudin family 0.0012 PF12497 Estrogen receptor beta 0.0012 PF02159 Oestrogen receptor 0.0012 PF08983 Domain of unknown function (DUF1856), 0.0009 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0007 PF00042 Globin 0.0004 PF01061 ABC-2 type transporter 0.0002 PF00067 Cytochrome P450 0.0001 PF00089 Trypsin SUB603 O=C-C-N-C 0.1236 PF01401 Angiotensin-converting enzyme 0.0785 PF03073 TspO/MBR family 0.0770 PF09396 Thrombin light chain 0.0653 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0521 PF01471 Putative peptidoglycan binding domain 0.0521 PF00045 Hemopexin 0.0491 PF00102 Protein-tyrosine phosphatase 0.0474 PF02798 Glutathione S-transferase, N-terminal domain 0.0461 PF00043 Glutathione S-transferase, C-terminal domain 0.0458 PF00413 Matrixin 0.0363 PF05649 Peptidase family M13 0.0363 PF01431 Peptidase family M13 0.0293 PF08983 Domain of unknown function (DUF1856), 0.0292 PF01048 Phosphorylase superfamily 0.0287 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0219 PF01590 GAF domain 0.0208 PF00303 Thymidylate synthase 0.0164 PF00255 Glutathione peroxidase 0.0132 PF00051 Kringle domain 0.0115 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0112 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0109 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0109 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0108 PF06512 Sodium ion transport-associated 0.0098 PF01268 Formate--tetrahydrofolate ligase 0.0093 PF00854 POT family 0.0083 PF00551 Formyl transferase 0.0065 PF01808 AICARFT/IMPCHase bienzyme 0.0040 PF00868 Transglutaminase family 0.0040 PF00927 Transglutaminase family, C-terminal ig like domain 0.0040 PF01841 Transglutaminase-like superfamily 0.0037 PF00026 Eukaryotic aspartyl protease 0.0035 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0035 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0035 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0033 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0028 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0028 PF01571 Aminomethyltransferase folate-binding domain 0.0027 PF07966 A1 Propeptide 0.0014 PF00089 Trypsin 0.0008 PF00586 AIR synthase related protein, N-terminal domain 0.0008 PF02769 AIR synthase related protein, C-terminal domain 0.0001 PF02142 MGS-like domain SUB309 O-H 0.1228 PF03098 Animal haem peroxidase 0.0978 PF00273 Serum albumin family 0.0962 PF00204 DNA gyrase B 0.0962 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0962 PF08070 DTHCT (NUC029), region 0.0750 PF00191 Annexin 0.0735 PF02155 Glucocorticoid receptor 0.0689 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0644 PF00105 Zinc finger, C4 type (two domains), 0.0636 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0589 PF01401 Angiotensin-converting enzyme 0.0538 PF00576 HIUase/Transthyretin family 0.0470 PF00102 Protein-tyrosine phosphatase 0.0409 PF00079 Serpin (serine protease inhibitor), 0.0403 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0329 PF01063 Aminotransferase class IV 0.0269 PF02159 Oestrogen receptor 0.0261 PF03953 Tubulin C-terminal domain 0.0261 PF00091 Tubulin/FtsZ family, GTPase domain 0.0248 PF00155 Aminotransferase class I and II 0.0233 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0173 PF01842 ACT domain 0.0157 PF00557 Metallopeptidase family M24 0.0153 PF00202 Aminotransferase class-III 0.0148 PF00303 Thymidylate synthase 0.0147 PF02806 Alpha amylase, C-terminal all-beta domain 0.0141 PF01735 Lysophospholipase catalytic domain 0.0129 PF02166 Androgen receptor 0.0084 PF00128 Alpha amylase, catalytic domain 0.0074 PF01268 Formate--tetrahydrofolate ligase 0.0068 PF00464 Serine hydroxymethyltransferase 0.0059 PF01126 Heme oxygenase 0.0058 PF05649 Peptidase family M13 0.0058 PF01431 Peptidase family M13 0.0057 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0057 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0044 PF03414 Glycosyltransferase family 6 0.0043 PF00248 Aldo/keto reductase family 0.0025 PF00175 Oxidoreductase NAD-binding domain 0.0025 PF00291 Pyridoxal-phosphate dependent enzyme 0.0019 PF00733 Asparagine synthase 0.0019 PF02898 Nitric oxide synthase, oxygenase domain 0.0014 PF00571 CBS domain 0.0012 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0012 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0012 PF00071 Ras family 0.0011 PF03171 2OG-Fe(II), oxygenase superfamily 0.0010 PF00266 Aminotransferase class-V 0.0010 PF07706 Aminotransferase ubiquitination site 0.0009 PF00258 Flavodoxin 0.0009 PF00667 FAD binding domain 0.0007 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0006 PF02798 Glutathione S-transferase, N-terminal domain 0.0002 PF00043 Glutathione S-transferase, C-terminal domain SUB612 N-C-C-N-C 0.1224 PF08070 DTHCT (NUC029), region 0.1224 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1224 PF00204 DNA gyrase B 0.0849 PF01048 Phosphorylase superfamily 0.0822 PF00186 Dihydrofolate reductase 0.0717 PF00001 7 transmembrane receptor (rhodopsin family), 0.0657 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0651 PF00069 Protein kinase domain 0.0585 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0482 PF00478 IMP dehydrogenase / GMP reductase domain 0.0434 PF01401 Angiotensin-converting enzyme 0.0335 PF03073 TspO/MBR family 0.0286 PF08240 Alcohol dehydrogenase GroES-like domain 0.0277 PF00571 CBS domain 0.0271 PF09396 Thrombin light chain 0.0253 PF00107 Zinc-binding dehydrogenase 0.0231 PF01590 GAF domain 0.0223 PF00962 Adenosine/AMP deaminase 0.0221 PF00017 SH2 domain 0.0215 PF02223 Thymidylate kinase 0.0214 PF00018 SH3 domain 0.0191 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0186 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0186 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0183 PF00045 Hemopexin 0.0183 PF01471 Putative peptidoglycan binding domain 0.0173 PF00102 Protein-tyrosine phosphatase 0.0169 PF00106 short chain dehydrogenase 0.0166 PF02798 Glutathione S-transferase, N-terminal domain 0.0162 PF00043 Glutathione S-transferase, C-terminal domain 0.0161 PF00413 Matrixin 0.0134 PF08919 F-actin binding 0.0132 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0127 PF01431 Peptidase family M13 0.0127 PF05649 Peptidase family M13 0.0107 PF00005 ABC transporter 0.0103 PF08983 Domain of unknown function (DUF1856), 0.0101 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0100 PF00858 Amiloride-sensitive sodium channel 0.0089 PF01467 Cytidylyltransferase 0.0087 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0087 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0087 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0080 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0075 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0073 PF00303 Thymidylate synthase 0.0070 PF00171 Aldehyde dehydrogenase family 0.0065 PF00156 Phosphoribosyl transferase domain 0.0058 PF00255 Glutathione peroxidase 0.0052 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0052 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0046 PF00051 Kringle domain 0.0041 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0041 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0041 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0038 PF06512 Sodium ion transport-associated 0.0035 PF01268 Formate--tetrahydrofolate ligase 0.0033 PF00854 POT family 0.0029 PF00551 Formyl transferase 0.0023 PF01808 AICARFT/IMPCHase bienzyme 0.0019 PF01687 Riboflavin kinase 0.0016 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0016 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0015 PF01061 ABC-2 type transporter 0.0014 PF00868 Transglutaminase family 0.0014 PF00927 Transglutaminase family, C-terminal ig like domain 0.0014 PF01841 Transglutaminase-like superfamily 0.0013 PF00026 Eukaryotic aspartyl protease 0.0013 PF02267 ADP-ribosyl cyclase 0.0012 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0012 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0012 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0012 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0011 PF00664 ABC transporter transmembrane region 0.0010 PF07966 A1 Propeptide 0.0010 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0010 PF01571 Aminomethyltransferase folate-binding domain 0.0005 PF00089 Trypsin 0.0004 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF02769 AIR synthase related protein, C-terminal domain 0.0003 PF02036 SCP-2 sterol transfer family 0.0003 PF00586 AIR synthase related protein, N-terminal domain 0.0003 PF01575 MaoC like domain SUB629 C-N-C-C:C 0.1216 PF03073 TspO/MBR family 0.1212 PF00194 Eukaryotic-type carbonic anhydrase 0.0942 PF00186 Dihydrofolate reductase 0.0679 PF00069 Protein kinase domain 0.0523 PF01048 Phosphorylase superfamily 0.0494 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0490 PF00001 7 transmembrane receptor (rhodopsin family), 0.0470 PF08403 Amino acid permease N-terminal 0.0417 PF00204 DNA gyrase B 0.0417 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0417 PF08070 DTHCT (NUC029), region 0.0358 PF06512 Sodium ion transport-associated 0.0286 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0286 PF02254 TrkA-N domain 0.0243 PF00005 ABC transporter 0.0229 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0184 PF00478 IMP dehydrogenase / GMP reductase domain 0.0166 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0162 PF01126 Heme oxygenase 0.0140 PF00962 Adenosine/AMP deaminase 0.0128 PF01061 ABC-2 type transporter 0.0128 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0123 PF00017 SH2 domain 0.0118 PF00520 Ion transport protein 0.0111 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0111 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0108 PF00018 SH3 domain 0.0102 PF01590 GAF domain 0.0094 PF00664 ABC transporter transmembrane region 0.0079 PF00571 CBS domain 0.0076 PF00042 Globin 0.0066 PF00102 Protein-tyrosine phosphatase 0.0063 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0063 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0052 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0043 PF00156 Phosphoribosyl transferase domain 0.0039 PF00464 Serine hydroxymethyltransferase 0.0032 PF08919 F-actin binding 0.0029 PF00858 Amiloride-sensitive sodium channel 0.0026 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0026 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0025 PF01268 Formate--tetrahydrofolate ligase 0.0020 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB591 C-C:C-O-[#1] 0.1216 PF02159 Oestrogen receptor 0.0642 PF00001 7 transmembrane receptor (rhodopsin family), 0.0526 PF00105 Zinc finger, C4 type (two domains), 0.0513 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0491 PF00204 DNA gyrase B 0.0491 PF08070 DTHCT (NUC029), region 0.0491 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0245 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0238 PF00576 HIUase/Transthyretin family 0.0238 PF12497 Estrogen receptor beta 0.0191 PF00976 Corticotropin ACTH domain 0.0191 PF08384 Pro-opiomelanocortin, N-terminal region 0.0191 PF08035 Opioids neuropeptide 0.0183 PF00102 Protein-tyrosine phosphatase 0.0179 PF00989 PAS fold 0.0177 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0146 PF00027 Cyclic nucleotide-binding domain 0.0143 PF00005 ABC transporter 0.0141 PF00664 ABC transporter transmembrane region 0.0120 PF11825 Protein of unknown function (DUF3345), 0.0100 PF00643 B-box zinc finger 0.0092 PF01596 O-methyltransferase 0.0068 PF01477 PLAT/LH2 domain 0.0067 PF00305 Lipoxygenase 0.0064 PF00340 Interleukin-1 / 18 0.0064 PF02394 Interleukin-1 propeptide 0.0064 PF03062 MBOAT family 0.0054 PF08983 Domain of unknown function (DUF1856), 0.0038 PF04622 ERG2 and Sigma1 receptor like protein 0.0034 PF00656 Caspase domain 0.0034 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0033 PF00183 Hsp90 protein 0.0033 PF01160 Vertebrate endogenous opioids neuropeptide 0.0033 PF00918 Gastrin/cholecystokinin family 0.0023 PF01180 Dihydroorotate dehydrogenase 0.0023 PF01588 Putative tRNA binding domain 0.0022 PF00135 Carboxylesterase 0.0021 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0021 PF03765 CRAL/TRIO, N-terminus 0.0021 PF00650 CRAL/TRIO domain 0.0021 PF08377 MAP2/Tau projection domain 0.0021 PF02180 Bcl-2 homology region 4 0.0021 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0020 PF00377 Prion/Doppel alpha-helical domain 0.0020 PF02460 Patched family 0.0020 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0019 PF00884 Sulfatase 0.0019 PF06327 Domain of Unknown Function (DUF1053), 0.0019 PF08441 Integrin alpha 0.0017 PF00625 Guanylate kinase 0.0016 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0016 PF00357 Integrin alpha cytoplasmic region 0.0012 PF07885 Ion channel 0.0012 PF09396 Thrombin light chain 0.0010 PF00229 TNF(Tumour Necrosis Factor), family 0.0009 PF00002 7 transmembrane receptor (Secretin family), 0.0009 PF00341 Platelet-derived growth factor (PDGF), 0.0009 PF02793 Hormone receptor domain 0.0008 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0008 PF02201 SWIB/MDM2 domain 0.0008 PF02025 Interleukin 5 0.0008 PF09193 Cholecystokinin A receptor, N-terminal 0.0008 PF08742 C8 domain 0.0008 PF00094 von Willebrand factor type D domain 0.0008 PF00641 Zn-finger in Ran binding protein and others 0.0008 PF08763 Voltage gated calcium channel IQ domain 0.0007 PF00170 bZIP transcription factor 0.0007 PF00068 Phospholipase A2 0.0006 PF00757 Furin-like cysteine rich region 0.0006 PF00091 Tubulin/FtsZ family, GTPase domain 0.0006 PF03953 Tubulin C-terminal domain 0.0006 PF01030 Receptor L domain 0.0005 PF02173 pKID domain 0.0005 PF01733 Nucleoside transporter 0.0005 PF00620 RhoGAP domain 0.0005 PF00266 Aminotransferase class-V 0.0004 PF01347 Lipoprotein amino terminal region 0.0003 PF00151 Lipase SUB419 C=N 0.1215 PF03073 TspO/MBR family 0.0895 PF00069 Protein kinase domain 0.0829 PF00186 Dihydrofolate reductase 0.0767 PF01048 Phosphorylase superfamily 0.0572 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0429 PF00478 IMP dehydrogenase / GMP reductase domain 0.0372 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0313 PF00091 Tubulin/FtsZ family, GTPase domain 0.0313 PF03953 Tubulin C-terminal domain 0.0304 PF00571 CBS domain 0.0270 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0270 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0230 PF00962 Adenosine/AMP deaminase 0.0205 PF01126 Heme oxygenase 0.0184 PF01590 GAF domain 0.0118 PF00156 Phosphoribosyl transferase domain 0.0117 PF08240 Alcohol dehydrogenase GroES-like domain 0.0115 PF00017 SH2 domain 0.0106 PF00042 Globin 0.0096 PF00107 Zinc-binding dehydrogenase 0.0088 PF00018 SH3 domain 0.0082 PF00858 Amiloride-sensitive sodium channel 0.0077 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0070 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0052 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0052 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0052 PF00343 Carbohydrate phosphorylase 0.0046 PF02267 ADP-ribosyl cyclase 0.0037 PF00106 short chain dehydrogenase 0.0028 PF08919 F-actin binding 0.0016 PF00005 ABC transporter 0.0007 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0003 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0003 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0003 PF00441 Acyl-CoA dehydrogenase, C-terminal domain SUB261 >= 3 hetero-aromatic rings 0.1208 PF00186 Dihydrofolate reductase 0.0642 PF00069 Protein kinase domain 0.0533 PF00478 IMP dehydrogenase / GMP reductase domain 0.0465 PF08240 Alcohol dehydrogenase GroES-like domain 0.0418 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0414 PF01048 Phosphorylase superfamily 0.0411 PF00107 Zinc-binding dehydrogenase 0.0380 PF00106 short chain dehydrogenase 0.0351 PF00571 CBS domain 0.0269 PF00962 Adenosine/AMP deaminase 0.0252 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0252 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0252 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0252 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0252 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0211 PF00171 Aldehyde dehydrogenase family 0.0172 PF00018 SH3 domain 0.0167 PF00248 Aldo/keto reductase family 0.0159 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0159 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0145 PF02223 Thymidylate kinase 0.0143 PF00156 Phosphoribosyl transferase domain 0.0124 PF00017 SH2 domain 0.0121 PF00501 AMP-binding enzyme 0.0109 PF08919 F-actin binding 0.0092 PF01467 Cytidylyltransferase 0.0073 PF00225 Kinesin motor domain 0.0071 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0071 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0070 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0063 PF01230 HIT domain 0.0061 PF00498 FHA domain 0.0061 PF00136 DNA polymerase family B 0.0061 PF01119 DNA mismatch repair protein, C-terminal domain 0.0061 PF12423 Kinesin protein 1B 0.0061 PF12473 Kinesin protein 0.0061 PF03104 DNA polymerase family B, exonuclease domain 0.0061 PF01575 MaoC like domain 0.0061 PF08996 DNA Polymerase alpha zinc finger 0.0061 PF02036 SCP-2 sterol transfer family 0.0061 PF08676 MutL C terminal dimerisation domain 0.0061 PF00970 Oxidoreductase FAD-binding domain 0.0060 PF00390 Malic enzyme, N-terminal domain 0.0060 PF03949 Malic enzyme, NAD binding domain 0.0055 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0055 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0055 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0055 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0050 PF02233 NAD(P), transhydrogenase beta subunit 0.0050 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0050 PF00931 NB-ARC domain 0.0050 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0050 PF00400 WD domain, G-beta repeat 0.0041 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0039 PF03477 ATP cone domain 0.0039 PF02867 Ribonucleotide reductase, barrel domain 0.0039 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0039 PF03770 Inositol polyphosphate kinase 0.0039 PF00317 Ribonucleotide reductase, all-alpha domain 0.0036 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0032 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0032 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0018 PF00757 Furin-like cysteine rich region 0.0018 PF01030 Receptor L domain 0.0017 PF01268 Formate--tetrahydrofolate ligase 0.0017 PF00858 Amiloride-sensitive sodium channel 0.0012 PF08515 Transforming growth factor beta type I GS-motif 0.0012 PF01064 Activin types I and II receptor domain 0.0011 PF00676 Dehydrogenase E1 component 0.0011 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0011 PF00378 Enoyl-CoA hydratase/isomerase family 0.0007 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0005 PF00005 ABC transporter 0.0002 PF01126 Heme oxygenase 0.0001 PF02525 Flavodoxin-like fold SUB687 O=C-C-C-C-O 0.1205 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1205 PF00204 DNA gyrase B 0.1205 PF08070 DTHCT (NUC029), region 0.0598 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0456 PF00102 Protein-tyrosine phosphatase 0.0306 PF01048 Phosphorylase superfamily 0.0295 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0196 PF00303 Thymidylate synthase 0.0178 PF01590 GAF domain 0.0167 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0150 PF02525 Flavodoxin-like fold 0.0145 PF00576 HIUase/Transthyretin family 0.0143 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0143 PF00533 BRCA1 C Terminus (BRCT), domain 0.0143 PF08063 PADR1 (NUC008), domain 0.0143 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0143 PF05406 WGR domain 0.0138 PF00821 Phosphoenolpyruvate carboxykinase 0.0135 PF01467 Cytidylyltransferase 0.0134 PF01268 Formate--tetrahydrofolate ligase 0.0127 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0127 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0120 PF01808 AICARFT/IMPCHase bienzyme 0.0115 PF00107 Zinc-binding dehydrogenase 0.0114 PF00106 short chain dehydrogenase 0.0111 PF08240 Alcohol dehydrogenase GroES-like domain 0.0104 PF00071 Ras family 0.0104 PF00248 Aldo/keto reductase family 0.0098 PF00464 Serine hydroxymethyltransferase 0.0095 PF00858 Amiloride-sensitive sodium channel 0.0091 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0084 PF00186 Dihydrofolate reductase 0.0082 PF01652 Eukaryotic initiation factor 4E 0.0080 PF02223 Thymidylate kinase 0.0076 PF00183 Hsp90 protein 0.0076 PF02142 MGS-like domain 0.0076 PF01370 NAD dependent epimerase/dehydratase family 0.0070 PF03098 Animal haem peroxidase 0.0067 PF00227 Proteasome subunit 0.0065 PF03024 Folate receptor family 0.0057 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0057 PF01571 Aminomethyltransferase folate-binding domain 0.0056 PF00551 Formyl transferase 0.0055 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0055 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0054 PF00155 Aminotransferase class I and II 0.0052 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0052 PF00266 Aminotransferase class-V 0.0050 PF00171 Aldehyde dehydrogenase family 0.0049 PF02267 ADP-ribosyl cyclase 0.0048 PF02036 SCP-2 sterol transfer family 0.0048 PF01575 MaoC like domain 0.0047 PF00025 ADP-ribosylation factor family 0.0045 PF00493 MCM2/3/5 family 0.0041 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0041 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0041 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0040 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0040 PF00305 Lipoxygenase 0.0040 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0039 PF01061 ABC-2 type transporter 0.0037 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0037 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0034 PF00291 Pyridoxal-phosphate dependent enzyme 0.0034 PF02233 NAD(P), transhydrogenase beta subunit 0.0032 PF00202 Aminotransferase class-III 0.0031 PF01063 Aminotransferase class IV 0.0030 PF00343 Carbohydrate phosphorylase 0.0029 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0029 PF08919 F-actin binding 0.0028 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0026 PF02219 Methylenetetrahydrofolate reductase 0.0026 PF00822 PMP-22/EMP/MP20/Claudin family 0.0026 PF00571 CBS domain 0.0026 PF00018 SH3 domain 0.0025 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0025 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0024 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0024 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0024 PF01731 Arylesterase 0.0024 PF00017 SH2 domain 0.0024 PF01180 Dihydroorotate dehydrogenase 0.0023 PF00999 Sodium/hydrogen exchanger family 0.0023 PF02059 Interleukin-3 0.0022 PF00294 pfkB family carbohydrate kinase 0.0022 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0022 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0021 PF00028 Cadherin domain 0.0021 PF03360 Glycosyltransferase family 43 0.0020 PF12491 Apolipoprotein B100 C terminal 0.0020 PF06448 Domain of Unknown Function (DUF1081), 0.0018 PF00550 Phosphopantetheine attachment site 0.0018 PF00478 IMP dehydrogenase / GMP reductase domain 0.0017 PF01023 S-100/ICaBP type calcium binding domain 0.0017 PF00702 haloacid dehalogenase-like hydrolase 0.0015 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0015 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0014 PF00586 AIR synthase related protein, N-terminal domain 0.0014 PF02911 Formyl transferase, C-terminal domain 0.0014 PF02769 AIR synthase related protein, C-terminal domain 0.0013 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0013 PF10420 Cytokine interleukin-12p40 C-terminus 0.0013 PF00390 Malic enzyme, N-terminal domain 0.0013 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0013 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0013 PF03949 Malic enzyme, NAD binding domain 0.0013 PF03473 MOSC domain 0.0013 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0013 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0013 PF03476 MOSC N-terminal beta barrel domain 0.0012 PF01212 Beta-eliminating lyase 0.0012 PF01202 Shikimate kinase 0.0012 PF02347 Glycine cleavage system P-protein 0.0012 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0012 PF04961 Formiminotransferase-cyclodeaminase 0.0012 PF07706 Aminotransferase ubiquitination site 0.0012 PF01168 Alanine racemase, N-terminal domain 0.0012 PF02971 Formiminotransferase domain 0.0012 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0011 PF00377 Prion/Doppel alpha-helical domain 0.0011 PF07722 Peptidase C26 0.0010 PF01227 GTP cyclohydrolase I 0.0010 PF01347 Lipoprotein amino terminal region 0.0010 PF01404 Ephrin receptor ligand binding domain 0.0010 PF00536 SAM domain (Sterile alpha motif), 0.0009 PF01596 O-methyltransferase 0.0008 PF08403 Amino acid permease N-terminal 0.0008 PF00264 Common central domain of tyrosinase 0.0007 PF00868 Transglutaminase family 0.0007 PF00654 Voltage gated chloride channel 0.0007 PF00656 Caspase domain 0.0007 PF00927 Transglutaminase family, C-terminal ig like domain 0.0007 PF00341 Platelet-derived growth factor (PDGF), 0.0007 PF01841 Transglutaminase-like superfamily 0.0006 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0006 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0006 PF00340 Interleukin-1 / 18 0.0006 PF02394 Interleukin-1 propeptide 0.0004 PF01916 Deoxyhypusine synthase 0.0004 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0003 PF00342 Phosphoglucose isomerase 0.0003 PF00689 Cation transporting ATPase, C-terminus 0.0003 PF00690 Cation transporter/ATPase, N-terminus 0.0002 PF00122 E1-E2 ATPase 0.0002 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0002 PF01588 Putative tRNA binding domain 0.0002 PF00676 Dehydrogenase E1 component 0.0001 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0001 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0001 PF00149 Calcineurin-like phosphoesterase SUB23 >= 16 O 0.1203 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.1203 PF08702 Fibrinogen alpha/beta chain family 0.0753 PF00273 Serum albumin family 0.0687 PF12160 Fibrinogen alpha C domain 0.0685 PF09396 Thrombin light chain 0.0522 PF00167 Fibroblast growth factor 0.0461 PF01459 Eukaryotic porin 0.0406 PF00079 Serpin (serine protease inhibitor), 0.0402 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0343 PF00051 Kringle domain 0.0333 PF00089 Trypsin 0.0205 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0203 PF02146 Sir2 family 0.0169 PF00024 PAN domain 0.0165 PF00405 Transferrin 0.0105 PF00854 POT family 0.0089 PF02806 Alpha amylase, C-terminal all-beta domain 0.0085 PF00690 Cation transporter/ATPase, N-terminus 0.0085 PF00689 Cation transporting ATPase, C-terminus 0.0081 PF00059 Lectin C-type domain 0.0076 PF00122 E1-E2 ATPase 0.0073 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0070 PF00128 Alpha amylase, catalytic domain 0.0058 PF00702 haloacid dehalogenase-like hydrolase 0.0053 PF00084 Sushi domain (SCR repeat), 0.0052 PF00002 7 transmembrane receptor (Secretin family), 0.0052 PF02793 Hormone receptor domain 0.0051 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0048 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0048 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0048 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0048 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0045 PF01055 Glycosyl hydrolases family 31 0.0045 PF00088 Trefoil (P-type), domain 0.0044 PF09193 Cholecystokinin A receptor, N-terminal 0.0042 PF01068 ATP dependent DNA ligase domain 0.0042 PF04679 ATP dependent DNA ligase C terminal region 0.0036 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0035 PF01370 NAD dependent epimerase/dehydratase family 0.0035 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0035 PF00188 Cysteine-rich secretory protein family 0.0035 PF00578 AhpC/TSA family 0.0033 PF01323 DSBA-like thioredoxin domain 0.0033 PF01731 Arylesterase 0.0032 PF03414 Glycosyltransferase family 6 0.0031 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0031 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0030 PF02260 FATC domain 0.0030 PF02259 FAT domain 0.0030 PF08771 Rapamycin binding domain 0.0027 PF02460 Patched family 0.0027 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0027 PF02180 Bcl-2 homology region 4 0.0026 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0026 PF03489 Saposin-like type B, region 2 0.0025 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0024 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0024 PF03062 MBOAT family 0.0024 PF01835 MG2 domain 0.0024 PF07677 A-macroglobulin receptor 0.0024 PF07678 A-macroglobulin complement component 0.0023 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0023 PF00439 Bromodomain 0.0022 PF00581 Rhodanese-like domain 0.0022 PF06617 M-phase inducer phosphatase 0.0020 PF03073 TspO/MBR family 0.0020 PF03770 Inositol polyphosphate kinase 0.0019 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0019 PF01652 Eukaryotic initiation factor 4E 0.0018 PF00169 PH domain 0.0016 PF00091 Tubulin/FtsZ family, GTPase domain 0.0016 PF03953 Tubulin C-terminal domain 0.0015 PF02233 NAD(P), transhydrogenase beta subunit 0.0015 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0015 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0014 PF08983 Domain of unknown function (DUF1856), 0.0014 PF02267 ADP-ribosyl cyclase 0.0012 PF00248 Aldo/keto reductase family 0.0011 PF00151 Lipase 0.0011 PF05193 Peptidase M16 inactive domain 0.0011 PF00675 Insulinase (Peptidase family M16), 0.0011 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0011 PF00378 Enoyl-CoA hydratase/isomerase family 0.0010 PF02803 Thiolase, C-terminal domain 0.0010 PF00108 Thiolase, N-terminal domain 0.0010 PF00106 short chain dehydrogenase 0.0010 PF00431 CUB domain 0.0009 PF00171 Aldehyde dehydrogenase family 0.0008 PF03360 Glycosyltransferase family 43 0.0008 PF07645 Calcium-binding EGF domain 0.0008 PF00406 Adenylate kinase 0.0007 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0007 PF00779 BTK motif 0.0007 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0007 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0006 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0006 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0006 PF01122 Eukaryotic cobalamin-binding protein 0.0005 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0004 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0004 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0004 PF01433 Peptidase family M1 0.0004 PF02223 Thymidylate kinase 0.0004 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0001 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0001 PF01852 START domain 0.0001 PF00698 Acyl transferase domain 0.0001 PF01923 Cobalamin adenosyltransferase 0.0001 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0001 PF01642 Methylmalonyl-CoA mutase 0.0001 PF00583 Acetyltransferase (GNAT), family 0.0001 PF00975 Thioesterase domain 0.0001 PF03308 ArgK protein 0.0001 PF08659 KR domain SUB620 O-C-C=C-C 0.1202 PF02159 Oestrogen receptor 0.0635 PF00001 7 transmembrane receptor (rhodopsin family), 0.0520 PF00105 Zinc finger, C4 type (two domains), 0.0507 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0485 PF08070 DTHCT (NUC029), region 0.0485 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0485 PF00204 DNA gyrase B 0.0243 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0235 PF00576 HIUase/Transthyretin family 0.0235 PF12497 Estrogen receptor beta 0.0189 PF08384 Pro-opiomelanocortin, N-terminal region 0.0189 PF08035 Opioids neuropeptide 0.0189 PF00976 Corticotropin ACTH domain 0.0181 PF00102 Protein-tyrosine phosphatase 0.0177 PF00989 PAS fold 0.0175 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0144 PF00027 Cyclic nucleotide-binding domain 0.0141 PF00005 ABC transporter 0.0139 PF00664 ABC transporter transmembrane region 0.0118 PF11825 Protein of unknown function (DUF3345), 0.0099 PF00643 B-box zinc finger 0.0091 PF01596 O-methyltransferase 0.0067 PF01477 PLAT/LH2 domain 0.0066 PF00305 Lipoxygenase 0.0063 PF02394 Interleukin-1 propeptide 0.0063 PF00340 Interleukin-1 / 18 0.0063 PF03062 MBOAT family 0.0053 PF08983 Domain of unknown function (DUF1856), 0.0038 PF04622 ERG2 and Sigma1 receptor like protein 0.0034 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0033 PF00918 Gastrin/cholecystokinin family 0.0033 PF01160 Vertebrate endogenous opioids neuropeptide 0.0033 PF00656 Caspase domain 0.0033 PF00183 Hsp90 protein 0.0022 PF01588 Putative tRNA binding domain 0.0022 PF01180 Dihydroorotate dehydrogenase 0.0021 PF08377 MAP2/Tau projection domain 0.0021 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0021 PF03765 CRAL/TRIO, N-terminus 0.0021 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0021 PF00650 CRAL/TRIO domain 0.0021 PF00135 Carboxylesterase 0.0021 PF02180 Bcl-2 homology region 4 0.0020 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0020 PF02460 Patched family 0.0020 PF00377 Prion/Doppel alpha-helical domain 0.0019 PF06327 Domain of Unknown Function (DUF1053), 0.0019 PF00884 Sulfatase 0.0019 PF08441 Integrin alpha 0.0017 PF00625 Guanylate kinase 0.0016 PF00357 Integrin alpha cytoplasmic region 0.0016 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0012 PF09396 Thrombin light chain 0.0012 PF07885 Ion channel 0.0010 PF00229 TNF(Tumour Necrosis Factor), family 0.0009 PF00002 7 transmembrane receptor (Secretin family), 0.0009 PF00341 Platelet-derived growth factor (PDGF), 0.0009 PF02793 Hormone receptor domain 0.0008 PF02201 SWIB/MDM2 domain 0.0008 PF02025 Interleukin 5 0.0008 PF08742 C8 domain 0.0008 PF00641 Zn-finger in Ran binding protein and others 0.0008 PF00094 von Willebrand factor type D domain 0.0008 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0008 PF09193 Cholecystokinin A receptor, N-terminal 0.0008 PF08763 Voltage gated calcium channel IQ domain 0.0007 PF00068 Phospholipase A2 0.0007 PF00170 bZIP transcription factor 0.0006 PF03953 Tubulin C-terminal domain 0.0006 PF00091 Tubulin/FtsZ family, GTPase domain 0.0005 PF01030 Receptor L domain 0.0005 PF00266 Aminotransferase class-V 0.0005 PF01733 Nucleoside transporter 0.0005 PF02173 pKID domain 0.0005 PF00757 Furin-like cysteine rich region 0.0005 PF00620 RhoGAP domain 0.0004 PF01347 Lipoprotein amino terminal region 0.0003 PF00151 Lipase SUB13 >= 16 C 0.1199 PF02159 Oestrogen receptor 0.0868 PF00105 Zinc finger, C4 type (two domains), 0.0860 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0753 PF00001 7 transmembrane receptor (rhodopsin family), 0.0735 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0735 PF00204 DNA gyrase B 0.0735 PF08070 DTHCT (NUC029), region 0.0605 PF00191 Annexin 0.0554 PF02155 Glucocorticoid receptor 0.0470 PF02161 Progesterone receptor 0.0335 PF02166 Androgen receptor 0.0308 PF01735 Lysophospholipase catalytic domain 0.0303 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0249 PF00079 Serpin (serine protease inhibitor), 0.0190 PF08035 Opioids neuropeptide 0.0190 PF08384 Pro-opiomelanocortin, N-terminal region 0.0190 PF00976 Corticotropin ACTH domain 0.0161 PF12497 Estrogen receptor beta 0.0147 PF00005 ABC transporter 0.0141 PF01401 Angiotensin-converting enzyme 0.0134 PF00664 ABC transporter transmembrane region 0.0124 PF09396 Thrombin light chain 0.0123 PF00168 C2 domain 0.0097 PF03953 Tubulin C-terminal domain 0.0097 PF00091 Tubulin/FtsZ family, GTPase domain 0.0093 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0092 PF00989 PAS fold 0.0083 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0073 PF00186 Dihydrofolate reductase 0.0071 PF07884 Vitamin K epoxide reductase family 0.0069 PF00027 Cyclic nucleotide-binding domain 0.0044 PF00042 Globin 0.0035 PF00305 Lipoxygenase 0.0034 PF11825 Protein of unknown function (DUF3345), 0.0034 PF00051 Kringle domain 0.0033 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0033 PF00067 Cytochrome P450 0.0029 PF01061 ABC-2 type transporter 0.0027 PF00643 B-box zinc finger 0.0022 PF02394 Interleukin-1 propeptide 0.0022 PF00340 Interleukin-1 / 18 0.0021 PF00229 TNF(Tumour Necrosis Factor), family 0.0020 PF04622 ERG2 and Sigma1 receptor like protein 0.0020 PF07648 Kazal-type serine protease inhibitor domain 0.0018 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0016 PF00554 Rel homology domain (RHD), 0.0015 PF06327 Domain of Unknown Function (DUF1053), 0.0015 PF01477 PLAT/LH2 domain 0.0014 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0013 PF00357 Integrin alpha cytoplasmic region 0.0012 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0011 PF08441 Integrin alpha 0.0010 PF03765 CRAL/TRIO, N-terminus 0.0010 PF00650 CRAL/TRIO domain 0.0009 PF07885 Ion channel 0.0008 PF08771 Rapamycin binding domain 0.0008 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0008 PF02260 FATC domain 0.0008 PF02259 FAT domain 0.0008 PF03062 MBOAT family 0.0006 PF00212 Atrial natriuretic peptide 0.0005 PF00341 Platelet-derived growth factor (PDGF), 0.0002 PF02180 Bcl-2 homology region 4 0.0002 PF00452 Apoptosis regulator proteins, Bcl-2 family SUB641 C=C-C-C-C 0.1193 PF00001 7 transmembrane receptor (rhodopsin family), 0.0548 PF02159 Oestrogen receptor 0.0509 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0506 PF00105 Zinc finger, C4 type (two domains), 0.0503 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0483 PF03098 Animal haem peroxidase 0.0339 PF00209 Sodium:neurotransmitter symporter family 0.0233 PF06512 Sodium ion transport-associated 0.0231 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0231 PF00204 DNA gyrase B 0.0231 PF08070 DTHCT (NUC029), region 0.0183 PF00520 Ion transport protein 0.0142 PF03073 TspO/MBR family 0.0141 PF00191 Annexin 0.0135 PF02161 Progesterone receptor 0.0116 PF00194 Eukaryotic-type carbonic anhydrase 0.0110 PF00989 PAS fold 0.0105 PF09396 Thrombin light chain 0.0102 PF02155 Glucocorticoid receptor 0.0089 PF00027 Cyclic nucleotide-binding domain 0.0088 PF00067 Cytochrome P450 0.0065 PF01593 Flavin containing amine oxidoreductase 0.0046 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0040 PF00186 Dihydrofolate reductase 0.0038 PF01735 Lysophospholipase catalytic domain 0.0034 PF12497 Estrogen receptor beta 0.0033 PF01007 Inward rectifier potassium channel 0.0031 PF00305 Lipoxygenase 0.0025 PF00005 ABC transporter 0.0024 PF08403 Amino acid permease N-terminal 0.0019 PF00102 Protein-tyrosine phosphatase 0.0018 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0016 PF00576 HIUase/Transthyretin family 0.0011 PF00273 Serum albumin family 0.0010 PF00664 ABC transporter transmembrane region 0.0003 PF03953 Tubulin C-terminal domain 0.0003 PF00091 Tubulin/FtsZ family, GTPase domain 0.0003 PF07884 Vitamin K epoxide reductase family SUB611 C-O-C-O-C 0.1190 PF02806 Alpha amylase, C-terminal all-beta domain 0.0948 PF00128 Alpha amylase, catalytic domain 0.0926 PF03414 Glycosyltransferase family 6 0.0776 PF00204 DNA gyrase B 0.0776 PF08070 DTHCT (NUC029), region 0.0776 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0414 PF00079 Serpin (serine protease inhibitor), 0.0403 PF00059 Lectin C-type domain 0.0387 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0380 PF00167 Fibroblast growth factor 0.0362 PF00084 Sushi domain (SCR repeat), 0.0325 PF07654 Immunoglobulin C1-set domain 0.0291 PF00143 Interferon alpha/beta domain 0.0237 PF08702 Fibrinogen alpha/beta chain family 0.0237 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0211 PF02155 Glucocorticoid receptor 0.0181 PF12160 Fibrinogen alpha C domain 0.0174 PF03727 Hexokinase 0.0174 PF00349 Hexokinase 0.0168 PF01055 Glycosyl hydrolases family 31 0.0168 PF00088 Trefoil (P-type), domain 0.0166 PF01735 Lysophospholipase catalytic domain 0.0165 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0155 PF07686 Immunoglobulin V-set domain 0.0154 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0154 PF00293 NUDIX domain 0.0150 PF02065 Melibiase 0.0145 PF00337 Galactoside-binding lectin 0.0142 PF00328 Histidine acid phosphatase 0.0134 PF02267 ADP-ribosyl cyclase 0.0127 PF00689 Cation transporting ATPase, C-terminus 0.0127 PF00690 Cation transporter/ATPase, N-terminus 0.0126 PF07645 Calcium-binding EGF domain 0.0114 PF01068 ATP dependent DNA ligase domain 0.0114 PF04679 ATP dependent DNA ligase C terminal region 0.0111 PF01370 NAD dependent epimerase/dehydratase family 0.0110 PF00089 Trypsin 0.0100 PF00122 E1-E2 ATPase 0.0099 PF00041 Fibronectin type III domain 0.0085 PF00431 CUB domain 0.0084 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0071 PF00702 haloacid dehalogenase-like hydrolase 0.0056 PF00024 PAN domain 0.0054 PF01532 Glycosyl hydrolase family 47 0.0051 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0051 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0051 PF00403 Heavy-metal-associated domain 0.0051 PF04711 Apolipoprotein A-II (ApoA-II), 0.0051 PF00031 Cystatin domain 0.0046 PF00058 Low-density lipoprotein receptor repeat class B 0.0045 PF07648 Kazal-type serine protease inhibitor domain 0.0045 PF00057 Low-density lipoprotein receptor domain class A 0.0040 PF00884 Sulfatase 0.0037 PF00191 Annexin 0.0035 PF02055 O-Glycosyl hydrolase family 30 0.0035 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0034 PF03171 2OG-Fe(II), oxygenase superfamily 0.0030 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0030 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0030 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0030 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0030 PF00236 Glycoprotein hormone 0.0030 PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), 0.0030 PF00200 Disintegrin 0.0030 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0030 PF08516 ADAM cysteine-rich 0.0030 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0030 PF01869 BadF/BadG/BcrA/BcrD ATPase family 0.0030 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 0.0030 PF01562 Reprolysin family propeptide 0.0030 PF00090 Thrombospondin type 1 domain 0.0030 PF00093 von Willebrand factor type C domain 0.0030 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0030 PF00021 u-PAR/Ly-6 domain 0.0030 PF05735 Thrombospondin C-terminal region 0.0030 PF00703 domain 0.0024 PF00183 Hsp90 protein 0.0022 PF00714 Interferon gamma 0.0021 PF03781 Formylglycine-generating sulfatase enzyme 0.0020 PF10420 Cytokine interleukin-12p40 C-terminus 0.0017 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0012 PF07884 Vitamin K epoxide reductase family 0.0011 PF08718 Glycolipid transfer protein (GLTP), 0.0002 PF00176 SNF2 family N-terminal domain SUB380 C(~N)(:N) 0.1189 PF00186 Dihydrofolate reductase 0.0785 PF01048 Phosphorylase superfamily 0.0629 PF00478 IMP dehydrogenase / GMP reductase domain 0.0560 PF00069 Protein kinase domain 0.0489 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0359 PF03073 TspO/MBR family 0.0356 PF00571 CBS domain 0.0343 PF00962 Adenosine/AMP deaminase 0.0247 PF00156 Phosphoribosyl transferase domain 0.0223 PF01590 GAF domain 0.0202 PF00106 short chain dehydrogenase 0.0198 PF08240 Alcohol dehydrogenase GroES-like domain 0.0195 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0155 PF00018 SH3 domain 0.0154 PF00107 Zinc-binding dehydrogenase 0.0144 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0144 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0139 PF00017 SH2 domain 0.0139 PF08919 F-actin binding 0.0128 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0128 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0128 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0127 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0099 PF00858 Amiloride-sensitive sodium channel 0.0090 PF00171 Aldehyde dehydrogenase family 0.0089 PF09396 Thrombin light chain 0.0087 PF00757 Furin-like cysteine rich region 0.0087 PF01030 Receptor L domain 0.0082 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0078 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0078 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0072 PF01268 Formate--tetrahydrofolate ligase 0.0065 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0065 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0052 PF01687 Riboflavin kinase 0.0046 PF00821 Phosphoenolpyruvate carboxykinase 0.0039 PF00501 AMP-binding enzyme 0.0031 PF01808 AICARFT/IMPCHase bienzyme 0.0016 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0016 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0015 PF03477 ATP cone domain 0.0015 PF02867 Ribonucleotide reductase, barrel domain 0.0015 PF00317 Ribonucleotide reductase, all-alpha domain 0.0012 PF02267 ADP-ribosyl cyclase 0.0009 PF01467 Cytidylyltransferase 0.0008 PF00136 DNA polymerase family B 0.0008 PF08996 DNA Polymerase alpha zinc finger 0.0008 PF03104 DNA polymerase family B, exonuclease domain 0.0008 PF00536 SAM domain (Sterile alpha motif), 0.0008 PF02223 Thymidylate kinase 0.0008 PF10397 Adenylosuccinate lyase C-terminus 0.0008 PF01404 Ephrin receptor ligand binding domain 0.0007 PF01575 MaoC like domain 0.0007 PF12423 Kinesin protein 1B 0.0007 PF02036 SCP-2 sterol transfer family 0.0007 PF01119 DNA mismatch repair protein, C-terminal domain 0.0007 PF12473 Kinesin protein 0.0007 PF01652 Eukaryotic initiation factor 4E 0.0007 PF00970 Oxidoreductase FAD-binding domain 0.0007 PF08676 MutL C terminal dimerisation domain 0.0007 PF00498 FHA domain 0.0006 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF01122 Eukaryotic cobalamin-binding protein 0.0002 PF01230 HIT domain SUB499 O-C=C-C 0.1188 PF02159 Oestrogen receptor 0.0948 PF00001 7 transmembrane receptor (rhodopsin family), 0.0711 PF00204 DNA gyrase B 0.0711 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0711 PF08070 DTHCT (NUC029), region 0.0565 PF00576 HIUase/Transthyretin family 0.0501 PF00105 Zinc finger, C4 type (two domains), 0.0486 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0360 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0265 PF12497 Estrogen receptor beta 0.0260 PF00989 PAS fold 0.0205 PF03098 Animal haem peroxidase 0.0194 PF00027 Cyclic nucleotide-binding domain 0.0184 PF00664 ABC transporter transmembrane region 0.0178 PF00005 ABC transporter 0.0164 PF11825 Protein of unknown function (DUF3345), 0.0154 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0153 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0140 PF08674 Acetylcholinesterase tetramerisation domain 0.0133 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0119 PF00135 Carboxylesterase 0.0115 PF00266 Aminotransferase class-V 0.0093 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0093 PF01596 O-methyltransferase 0.0086 PF00186 Dihydrofolate reductase 0.0082 PF01477 PLAT/LH2 domain 0.0080 PF07884 Vitamin K epoxide reductase family 0.0074 PF00702 haloacid dehalogenase-like hydrolase 0.0072 PF00155 Aminotransferase class I and II 0.0067 PF00976 Corticotropin ACTH domain 0.0067 PF08384 Pro-opiomelanocortin, N-terminal region 0.0067 PF08035 Opioids neuropeptide 0.0051 PF00656 Caspase domain 0.0048 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0046 PF00183 Hsp90 protein 0.0046 PF00305 Lipoxygenase 0.0045 PF08983 Domain of unknown function (DUF1856), 0.0042 PF00273 Serum albumin family 0.0041 PF03765 CRAL/TRIO, N-terminus 0.0041 PF00650 CRAL/TRIO domain 0.0041 PF00643 B-box zinc finger 0.0041 PF08441 Integrin alpha 0.0035 PF00068 Phospholipase A2 0.0029 PF03062 MBOAT family 0.0029 PF02394 Interleukin-1 propeptide 0.0029 PF00294 pfkB family carbohydrate kinase 0.0029 PF01588 Putative tRNA binding domain 0.0029 PF00340 Interleukin-1 / 18 0.0024 PF00357 Integrin alpha cytoplasmic region 0.0008 PF00291 Pyridoxal-phosphate dependent enzyme 0.0008 PF07885 Ion channel 0.0007 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0007 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0007 PF00102 Protein-tyrosine phosphatase 0.0007 PF00151 Lipase 0.0005 PF07966 A1 Propeptide SUB673 O=C-C=C-[#1] 0.1183 PF03098 Animal haem peroxidase 0.1180 PF08070 DTHCT (NUC029), region 0.1180 PF00204 DNA gyrase B 0.1180 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0671 PF00191 Annexin 0.0589 PF02155 Glucocorticoid receptor 0.0552 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0498 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0494 PF00105 Zinc finger, C4 type (two domains), 0.0486 PF00273 Serum albumin family 0.0422 PF00102 Protein-tyrosine phosphatase 0.0333 PF07884 Vitamin K epoxide reductase family 0.0222 PF01735 Lysophospholipase catalytic domain 0.0208 PF00005 ABC transporter 0.0198 PF06512 Sodium ion transport-associated 0.0187 PF02161 Progesterone receptor 0.0166 PF02525 Flavodoxin-like fold 0.0157 PF00576 HIUase/Transthyretin family 0.0154 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0152 PF00079 Serpin (serine protease inhibitor), 0.0150 PF01268 Formate--tetrahydrofolate ligase 0.0147 PF00464 Serine hydroxymethyltransferase 0.0146 PF02166 Androgen receptor 0.0144 PF00664 ABC transporter transmembrane region 0.0137 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0137 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0136 PF09396 Thrombin light chain 0.0117 PF00051 Kringle domain 0.0117 PF00089 Trypsin 0.0105 PF00554 Rel homology domain (RHD), 0.0100 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0100 PF08063 PADR1 (NUC008), domain 0.0100 PF00533 BRCA1 C Terminus (BRCT), domain 0.0100 PF05406 WGR domain 0.0100 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0089 PF01061 ABC-2 type transporter 0.0087 PF08403 Amino acid permease N-terminal 0.0086 PF00551 Formyl transferase 0.0080 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0077 PF11825 Protein of unknown function (DUF3345), 0.0074 PF00017 SH2 domain 0.0067 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0067 PF01571 Aminomethyltransferase folate-binding domain 0.0046 PF00018 SH3 domain 0.0044 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0044 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0044 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0039 PF02219 Methylenetetrahydrofolate reductase 0.0037 PF00531 Death domain 0.0035 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0025 PF00229 TNF(Tumour Necrosis Factor), family 0.0024 PF00183 Hsp90 protein 0.0018 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0014 PF01467 Cytidylyltransferase 0.0011 PF02911 Formyl transferase, C-terminal domain 0.0011 PF03024 Folate receptor family 0.0011 PF00343 Carbohydrate phosphorylase 0.0007 PF00248 Aldo/keto reductase family 0.0002 PF01180 Dihydroorotate dehydrogenase SUB778 CC1CCC(O)CC1 0.1177 PF02159 Oestrogen receptor 0.0943 PF00105 Zinc finger, C4 type (two domains), 0.0931 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0752 PF00191 Annexin 0.0689 PF02155 Glucocorticoid receptor 0.0543 PF00204 DNA gyrase B 0.0543 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0543 PF08070 DTHCT (NUC029), region 0.0477 PF00001 7 transmembrane receptor (rhodopsin family), 0.0369 PF01735 Lysophospholipase catalytic domain 0.0350 PF00079 Serpin (serine protease inhibitor), 0.0332 PF02161 Progesterone receptor 0.0291 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0243 PF00091 Tubulin/FtsZ family, GTPase domain 0.0243 PF03953 Tubulin C-terminal domain 0.0190 PF02166 Androgen receptor 0.0181 PF00976 Corticotropin ACTH domain 0.0181 PF08384 Pro-opiomelanocortin, N-terminal region 0.0181 PF08035 Opioids neuropeptide 0.0176 PF12497 Estrogen receptor beta 0.0174 PF00005 ABC transporter 0.0156 PF00664 ABC transporter transmembrane region 0.0153 PF00168 C2 domain 0.0150 PF00989 PAS fold 0.0148 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0124 PF00027 Cyclic nucleotide-binding domain 0.0074 PF01477 PLAT/LH2 domain 0.0072 PF00273 Serum albumin family 0.0062 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0061 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0059 PF03414 Glycosyltransferase family 6 0.0053 PF00822 PMP-22/EMP/MP20/Claudin family 0.0050 PF00067 Cytochrome P450 0.0049 PF01401 Angiotensin-converting enzyme 0.0041 PF00102 Protein-tyrosine phosphatase 0.0040 PF02806 Alpha amylase, C-terminal all-beta domain 0.0037 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0036 PF11825 Protein of unknown function (DUF3345), 0.0035 PF00183 Hsp90 protein 0.0034 PF00305 Lipoxygenase 0.0033 PF03098 Animal haem peroxidase 0.0032 PF07966 A1 Propeptide 0.0032 PF00557 Metallopeptidase family M24 0.0031 PF02180 Bcl-2 homology region 4 0.0031 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0030 PF00229 TNF(Tumour Necrosis Factor), family 0.0029 PF07648 Kazal-type serine protease inhibitor domain 0.0027 PF00554 Rel homology domain (RHD), 0.0025 PF00151 Lipase 0.0025 PF00026 Eukaryotic aspartyl protease 0.0023 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0020 PF09396 Thrombin light chain 0.0018 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0018 PF03062 MBOAT family 0.0017 PF01061 ABC-2 type transporter 0.0016 PF02394 Interleukin-1 propeptide 0.0016 PF00340 Interleukin-1 / 18 0.0016 PF02173 pKID domain 0.0014 PF07884 Vitamin K epoxide reductase family 0.0014 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0014 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0013 PF02259 FAT domain 0.0013 PF08771 Rapamycin binding domain 0.0013 PF07690 Major Facilitator Superfamily 0.0013 PF02260 FATC domain 0.0012 PF00186 Dihydrofolate reductase 0.0012 PF00643 B-box zinc finger 0.0011 PF00170 bZIP transcription factor 0.0010 PF00656 Caspase domain 0.0010 PF00341 Platelet-derived growth factor (PDGF), 0.0010 PF01347 Lipoprotein amino terminal region 0.0009 PF08441 Integrin alpha 0.0009 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0009 PF08763 Voltage gated calcium channel IQ domain 0.0009 PF00059 Lectin C-type domain 0.0009 PF03171 2OG-Fe(II), oxygenase superfamily 0.0008 PF00531 Death domain 0.0008 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0007 PF00042 Globin 0.0007 PF00094 von Willebrand factor type D domain 0.0007 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0007 PF02525 Flavodoxin-like fold 0.0007 PF02025 Interleukin 5 0.0007 PF08742 C8 domain 0.0006 PF00271 Helicase conserved C-terminal domain 0.0006 PF00975 Thioesterase domain 0.0006 PF00176 SNF2 family N-terminal domain 0.0006 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0006 PF00432 Prenyltransferase and squalene oxidase repeat 0.0006 PF08659 KR domain 0.0006 PF00698 Acyl transferase domain 0.0006 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0005 PF01596 O-methyltransferase 0.0005 PF00493 MCM2/3/5 family 0.0005 PF00051 Kringle domain 0.0005 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0004 PF00128 Alpha amylase, catalytic domain 0.0004 PF01391 Collagen triple helix repeat (20 copies), 0.0004 PF00023 Ankyrin repeat 0.0004 PF02758 PAAD/DAPIN/Pyrin domain 0.0003 PF00489 Interleukin-6/G-CSF/MGF family 0.0003 PF02887 Pyruvate kinase, alpha/beta domain 0.0003 PF00167 Fibroblast growth factor 0.0003 PF03765 CRAL/TRIO, N-terminus 0.0003 PF04622 ERG2 and Sigma1 receptor like protein 0.0003 PF00224 Pyruvate kinase, barrel domain 0.0003 PF00650 CRAL/TRIO domain 0.0003 PF00274 Fructose-bisphosphate aldolase class-I 0.0003 PF03360 Glycosyltransferase family 43 0.0003 PF00377 Prion/Doppel alpha-helical domain 0.0003 PF00040 Fibronectin type II domain 0.0002 PF03623 Focal adhesion targeting region 0.0002 PF12491 Apolipoprotein B100 C terminal 0.0002 PF00071 Ras family 0.0002 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0002 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0002 PF06448 Domain of Unknown Function (DUF1081), 0.0002 PF00969 Class II histocompatibility antigen, beta domain 0.0002 PF07885 Ion channel 0.0002 PF02460 Patched family 0.0002 PF00622 SPRY domain 0.0002 PF06327 Domain of Unknown Function (DUF1053), 0.0002 PF00354 Pentaxin family 0.0002 PF00357 Integrin alpha cytoplasmic region 0.0001 PF01023 S-100/ICaBP type calcium binding domain 0.0001 PF00342 Phosphoglucose isomerase 0.0001 PF00074 Pancreatic ribonuclease 0.0001 PF00212 Atrial natriuretic peptide SUB583 C-C-C-C-C 0.1121 PF00001 7 transmembrane receptor (rhodopsin family), 0.0626 PF00105 Zinc finger, C4 type (two domains), 0.0622 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0588 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0549 PF02159 Oestrogen receptor 0.0357 PF00209 Sodium:neurotransmitter symporter family 0.0247 PF03098 Animal haem peroxidase 0.0231 PF08070 DTHCT (NUC029), region 0.0231 PF00204 DNA gyrase B 0.0231 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0118 PF03953 Tubulin C-terminal domain 0.0118 PF00091 Tubulin/FtsZ family, GTPase domain 0.0117 PF00989 PAS fold 0.0097 PF09396 Thrombin light chain 0.0093 PF00027 Cyclic nucleotide-binding domain 0.0092 PF00005 ABC transporter 0.0083 PF00067 Cytochrome P450 0.0078 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0078 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0065 PF00664 ABC transporter transmembrane region 0.0034 PF00273 Serum albumin family 0.0033 PF02161 Progesterone receptor 0.0029 PF01593 Flavin containing amine oxidoreductase 0.0025 PF03073 TspO/MBR family 0.0021 PF12497 Estrogen receptor beta 0.0019 PF11825 Protein of unknown function (DUF3345), 0.0015 PF02166 Androgen receptor 0.0007 PF00061 Lipocalin / cytosolic fatty-acid binding protein family SUB369 C(~H)(~S) 0.1112 PF02798 Glutathione S-transferase, N-terminal domain 0.1087 PF00043 Glutathione S-transferase, C-terminal domain 0.0659 PF00255 Glutathione peroxidase 0.0530 PF01431 Peptidase family M13 0.0530 PF05649 Peptidase family M13 0.0462 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0372 PF01124 MAPEG family 0.0345 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0328 PF00091 Tubulin/FtsZ family, GTPase domain 0.0328 PF03953 Tubulin C-terminal domain 0.0319 PF01401 Angiotensin-converting enzyme 0.0301 PF09396 Thrombin light chain 0.0292 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0292 PF03199 Eukaryotic glutathione synthase 0.0224 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0221 PF01323 DSBA-like thioredoxin domain 0.0200 PF00656 Caspase domain 0.0196 PF08983 Domain of unknown function (DUF1856), 0.0186 PF00303 Thymidylate synthase 0.0173 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0162 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0161 PF00462 Glutaredoxin 0.0152 PF07722 Peptidase C26 0.0133 PF01406 tRNA synthetases class I (C), catalytic domain 0.0128 PF05995 Cysteine dioxygenase type I 0.0127 PF01019 Gamma-glutamyltranspeptidase 0.0127 PF00756 Putative esterase 0.0113 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0113 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0109 PF00619 Caspase recruitment domain 0.0106 PF03074 Glutamate-cysteine ligase 0.0074 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0072 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0072 PF00439 Bromodomain 0.0065 PF06617 M-phase inducer phosphatase 0.0065 PF00581 Rhodanese-like domain 0.0058 PF03002 Somatostatin/Cortistatin family 0.0057 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0056 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0049 PF00085 Thioredoxin 0.0048 PF08833 Axin beta-catenin binding domain 0.0048 PF00778 DIX domain 0.0048 PF00806 Pumilio-family RNA binding repeat 0.0047 PF00822 PMP-22/EMP/MP20/Claudin family 0.0043 PF00265 Thymidine kinase 0.0041 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0041 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0035 PF00931 NB-ARC domain 0.0035 PF00342 Phosphoglucose isomerase 0.0035 PF00400 WD domain, G-beta repeat 0.0026 PF02793 Hormone receptor domain 0.0026 PF00002 7 transmembrane receptor (Secretin family), 0.0019 PF01268 Formate--tetrahydrofolate ligase 0.0011 PF00586 AIR synthase related protein, N-terminal domain 0.0011 PF02769 AIR synthase related protein, C-terminal domain 0.0010 PF10420 Cytokine interleukin-12p40 C-terminus 0.0009 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0009 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0006 PF02803 Thiolase, C-terminal domain 0.0006 PF00108 Thiolase, N-terminal domain 0.0006 PF01471 Putative peptidoglycan binding domain 0.0006 PF00045 Hemopexin 0.0002 PF00551 Formyl transferase SUB716 Cc1ccc(S)cc1 0.1092 PF00194 Eukaryotic-type carbonic anhydrase 0.0366 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0366 PF02254 TrkA-N domain 0.0365 PF08403 Amino acid permease N-terminal 0.0179 PF00324 Amino acid permease 0.0135 PF00689 Cation transporting ATPase, C-terminus 0.0135 PF00690 Cation transporter/ATPase, N-terminus 0.0120 PF00122 E1-E2 ATPase 0.0107 PF00702 haloacid dehalogenase-like hydrolase 0.0082 PF01007 Inward rectifier potassium channel 0.0066 PF00102 Protein-tyrosine phosphatase 0.0066 PF00520 Ion transport protein 0.0061 PF02146 Sir2 family 0.0052 PF10420 Cytokine interleukin-12p40 C-terminus 0.0048 PF01916 Deoxyhypusine synthase 0.0045 PF01471 Putative peptidoglycan binding domain 0.0045 PF00045 Hemopexin 0.0042 PF00413 Matrixin 0.0041 PF09396 Thrombin light chain 0.0036 PF02038 ATP1G1/PLM/MAT8 family 0.0035 PF00108 Thiolase, N-terminal domain 0.0035 PF00040 Fibronectin type II domain 0.0035 PF02803 Thiolase, C-terminal domain 0.0029 PF00043 Glutathione S-transferase, C-terminal domain 0.0028 PF00069 Protein kinase domain 0.0028 PF02798 Glutathione S-transferase, N-terminal domain 0.0027 PF08983 Domain of unknown function (DUF1856), 0.0019 PF00273 Serum albumin family 0.0019 PF00186 Dihydrofolate reductase 0.0015 PF00167 Fibroblast growth factor 0.0014 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0010 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0010 PF04679 ATP dependent DNA ligase C terminal region 0.0010 PF11857 Domain of unknown function (DUF3377), 0.0010 PF08702 Fibrinogen alpha/beta chain family 0.0010 PF00664 ABC transporter transmembrane region 0.0010 PF01068 ATP dependent DNA ligase domain 0.0009 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0007 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0007 PF02793 Hormone receptor domain 0.0007 PF04055 Radical SAM superfamily 0.0007 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0007 PF00051 Kringle domain 0.0007 PF08833 Axin beta-catenin binding domain 0.0007 PF00778 DIX domain 0.0007 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0007 PF00002 7 transmembrane receptor (Secretin family), 0.0007 PF03098 Animal haem peroxidase 0.0006 PF00020 TNFR/NGFR cysteine-rich region 0.0006 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0006 PF00005 ABC transporter 0.0005 PF00230 Major intrinsic protein 0.0005 PF08466 Inward rectifier potassium channel N-terminal 0.0005 PF01731 Arylesterase 0.0005 PF01369 Sec7 domain 0.0005 PF00265 Thymidine kinase 0.0004 PF12160 Fibrinogen alpha C domain 0.0004 PF00024 PAN domain 0.0004 PF03099 Biotin/lipoate A/B protein ligase family 0.0002 PF00058 Low-density lipoprotein receptor repeat class B 0.0002 PF00615 Regulator of G protein signaling domain 0.0002 PF01462 Leucine rich repeat N-terminal domain 0.0002 PF00474 Sodium:solute symporter family 0.0001 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0001 PF01234 NNMT/PNMT/TEMT family SUB548 N-C:C-N 0.1087 PF00227 Proteasome subunit 0.0157 PF01122 Eukaryotic cobalamin-binding protein 0.0151 PF01048 Phosphorylase superfamily 0.0130 PF00069 Protein kinase domain 0.0130 PF00478 IMP dehydrogenase / GMP reductase domain 0.0116 PF00186 Dihydrofolate reductase 0.0107 PF01923 Cobalamin adenosyltransferase 0.0107 PF03308 ArgK protein 0.0107 PF01642 Methylmalonyl-CoA mutase 0.0107 PF02310 B12 binding domain 0.0096 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0087 PF00571 CBS domain 0.0079 PF00962 Adenosine/AMP deaminase 0.0074 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0065 PF08240 Alcohol dehydrogenase GroES-like domain 0.0063 PF00156 Phosphoribosyl transferase domain 0.0062 PF00107 Zinc-binding dehydrogenase 0.0059 PF00106 short chain dehydrogenase 0.0053 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0052 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0052 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0049 PF01590 GAF domain 0.0048 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0048 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0048 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0046 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0045 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0045 PF00809 Pterin binding enzyme 0.0045 PF02607 B12 binding domain 0.0044 PF00431 CUB domain 0.0041 PF00258 Flavodoxin 0.0041 PF00667 FAD binding domain 0.0040 PF00858 Amiloride-sensitive sodium channel 0.0040 PF00175 Oxidoreductase NAD-binding domain 0.0039 PF00171 Aldehyde dehydrogenase family 0.0036 PF00017 SH2 domain 0.0035 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0035 PF01467 Cytidylyltransferase 0.0035 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0033 PF00018 SH3 domain 0.0031 PF02223 Thymidylate kinase 0.0029 PF07645 Calcium-binding EGF domain 0.0029 PF01126 Heme oxygenase 0.0026 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0026 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0026 PF00501 AMP-binding enzyme 0.0025 PF00970 Oxidoreductase FAD-binding domain 0.0025 PF01652 Eukaryotic initiation factor 4E 0.0024 PF08919 F-actin binding 0.0024 PF02036 SCP-2 sterol transfer family 0.0024 PF01575 MaoC like domain 0.0023 PF02574 Homocysteine S-methyltransferase 0.0022 PF01119 DNA mismatch repair protein, C-terminal domain 0.0022 PF12473 Kinesin protein 0.0022 PF12423 Kinesin protein 1B 0.0022 PF00498 FHA domain 0.0022 PF08676 MutL C terminal dimerisation domain 0.0021 PF01230 HIT domain 0.0021 PF02233 NAD(P), transhydrogenase beta subunit 0.0021 PF00136 DNA polymerase family B 0.0021 PF10397 Adenylosuccinate lyase C-terminus 0.0021 PF03104 DNA polymerase family B, exonuclease domain 0.0021 PF08996 DNA Polymerase alpha zinc finger 0.0020 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0020 PF00821 Phosphoenolpyruvate carboxykinase 0.0020 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0020 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0020 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0019 PF00225 Kinesin motor domain 0.0019 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0019 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0018 PF01808 AICARFT/IMPCHase bienzyme 0.0018 PF02525 Flavodoxin-like fold 0.0018 PF00400 WD domain, G-beta repeat 0.0018 PF00931 NB-ARC domain 0.0018 PF00248 Aldo/keto reductase family 0.0017 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0017 PF00390 Malic enzyme, N-terminal domain 0.0017 PF00676 Dehydrogenase E1 component 0.0017 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0017 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0017 PF07966 A1 Propeptide 0.0017 PF02267 ADP-ribosyl cyclase 0.0017 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0017 PF03949 Malic enzyme, NAD binding domain 0.0016 PF00689 Cation transporting ATPase, C-terminus 0.0016 PF00378 Enoyl-CoA hydratase/isomerase family 0.0016 PF03770 Inositol polyphosphate kinase 0.0016 PF00690 Cation transporter/ATPase, N-terminus 0.0015 PF00071 Ras family 0.0014 PF01064 Activin types I and II receptor domain 0.0014 PF00702 haloacid dehalogenase-like hydrolase 0.0014 PF08515 Transforming growth factor beta type I GS-motif 0.0013 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0013 PF00958 GMP synthase C terminal domain 0.0013 PF02867 Ribonucleotide reductase, barrel domain 0.0013 PF00317 Ribonucleotide reductase, all-alpha domain 0.0013 PF03477 ATP cone domain 0.0013 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0012 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0011 PF05347 Complex 1 protein (LYR family), 0.0011 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0011 PF03073 TspO/MBR family 0.0011 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0011 PF00310 Glutamine amidotransferases class-II 0.0010 PF09027 GTPase binding 0.0010 PF01268 Formate--tetrahydrofolate ligase 0.0010 PF00536 SAM domain (Sterile alpha motif), 0.0010 PF11555 EGFR receptor inhibitor Mig-6 0.0010 PF00122 E1-E2 ATPase 0.0010 PF01404 Ephrin receptor ligand binding domain 0.0009 PF00025 ADP-ribosylation factor family 0.0009 PF04679 ATP dependent DNA ligase C terminal region 0.0009 PF03024 Folate receptor family 0.0009 PF00334 Nucleoside diphosphate kinase 0.0009 PF01068 ATP dependent DNA ligase domain 0.0008 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0008 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0008 PF01712 Deoxynucleoside kinase 0.0008 PF01030 Receptor L domain 0.0008 PF00757 Furin-like cysteine rich region 0.0008 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0008 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0008 PF02779 Transketolase, pyrimidine binding domain 0.0007 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0007 PF00206 Lyase 0.0007 PF00042 Globin 0.0007 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0006 PF01687 Riboflavin kinase 0.0006 PF01370 NAD dependent epimerase/dehydratase family 0.0006 PF01916 Deoxyhypusine synthase 0.0006 PF00533 BRCA1 C Terminus (BRCT), domain 0.0006 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0006 PF00792 Phosphoinositide 3-kinase C2 0.0006 PF08063 PADR1 (NUC008), domain 0.0006 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0006 PF00794 PI3-kinase family, ras-binding domain 0.0006 PF05406 WGR domain 0.0006 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0006 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0005 PF03530 Calcium-activated SK potassium channel 0.0005 PF00005 ABC transporter 0.0005 PF02888 Calmodulin binding domain 0.0004 PF10276 Zinc-finger domain 0.0004 PF09326 Domain of unknown function (DUF1982), 0.0004 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0004 PF04716 ETC complex I subunit conserved region 0.0004 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0004 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0004 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0004 PF04800 ETC complex I subunit conserved region 0.0004 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0004 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0004 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0004 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0004 PF02466 Tim17/Tim22/Tim23 family 0.0004 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0004 PF10531 SLBB domain 0.0004 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0004 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0004 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0004 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0004 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0004 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0004 PF02772 S-adenosylmethionine synthetase, central domain 0.0004 PF00384 Molybdopterin oxidoreductase 0.0004 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0004 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0004 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0004 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0004 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0004 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0004 PF08040 MNLL subunit 0.0004 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0004 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0004 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0004 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0004 PF00183 Hsp90 protein 0.0004 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0004 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0004 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0004 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0004 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0004 PF00026 Eukaryotic aspartyl protease 0.0004 PF06212 GRIM-19 protein 0.0004 PF09166 Biliverdin reductase, catalytic 0.0004 PF04116 Fatty acid hydroxylase superfamily 0.0004 PF02817 e3 binding domain 0.0004 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0003 PF00856 SET domain 0.0003 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0003 PF08544 GHMP kinases C terminal 0.0003 PF01434 Peptidase family M41 0.0003 PF07677 A-macroglobulin receptor 0.0003 PF07678 A-macroglobulin complement component 0.0003 PF10509 Galactokinase galactose-binding signature 0.0003 PF01835 MG2 domain 0.0003 PF01747 ATP-sulfurylase 0.0003 PF00057 Low-density lipoprotein receptor domain class A 0.0003 PF00629 MAM domain 0.0003 PF00058 Low-density lipoprotein receptor repeat class B 0.0003 PF02493 MORN repeat 0.0003 PF01591 6-phosphofructo-2-kinase 0.0003 PF02037 SAP domain 0.0003 PF12062 heparan sulfate-N-deacetylase 0.0003 PF00439 Bromodomain 0.0003 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0003 PF00300 Phosphoglycerate mutase family 0.0003 PF00899 ThiF family 0.0003 PF00288 GHMP kinases N terminal domain 0.0003 PF00221 Phenylalanine and histidine ammonia-lyase 0.0003 PF00287 Sodium / potassium ATPase beta chain 0.0003 PF02173 pKID domain 0.0003 PF00316 Fructose-1-6-bisphosphatase 0.0003 PF00004 ATPase family associated with various cellular activities (AAA), 0.0003 PF00348 Polyprenyl synthetase 0.0003 PF00012 Hsp70 protein 0.0003 PF01583 Adenylylsulphate kinase 0.0003 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0002 PF01582 TIR domain 0.0002 PF02793 Hormone receptor domain 0.0002 PF00343 Carbohydrate phosphorylase 0.0002 PF00002 7 transmembrane receptor (Secretin family), 0.0002 PF00615 Regulator of G protein signaling domain 0.0002 PF00291 Pyridoxal-phosphate dependent enzyme 0.0002 PF01437 Plexin repeat 0.0002 PF02196 Raf-like Ras-binding domain 0.0002 PF01403 Sema domain 0.0002 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0002 PF01833 IPT/TIG domain 0.0001 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0001 PF00108 Thiolase, N-terminal domain 0.0001 PF01061 ABC-2 type transporter 0.0001 PF02864 STAT protein, DNA binding domain 0.0001 PF02865 STAT protein, protein interaction domain 0.0001 PF02803 Thiolase, C-terminal domain 0.0001 PF03727 Hexokinase 0.0001 PF00619 Caspase recruitment domain 0.0001 PF01017 STAT protein, all-alpha domain 0.0001 PF00349 Hexokinase 0.0001 PF02142 MGS-like domain 0.0001 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region SUB570 N-C-C-N 0.1083 PF08070 DTHCT (NUC029), region 0.1083 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.1083 PF00204 DNA gyrase B 0.0790 PF01048 Phosphorylase superfamily 0.0728 PF00186 Dihydrofolate reductase 0.0635 PF00001 7 transmembrane receptor (rhodopsin family), 0.0603 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0581 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0576 PF00069 Protein kinase domain 0.0545 PF01401 Angiotensin-converting enzyme 0.0427 PF00478 IMP dehydrogenase / GMP reductase domain 0.0398 PF03073 TspO/MBR family 0.0340 PF09396 Thrombin light chain 0.0253 PF08240 Alcohol dehydrogenase GroES-like domain 0.0245 PF00571 CBS domain 0.0233 PF01590 GAF domain 0.0229 PF01471 Putative peptidoglycan binding domain 0.0229 PF00045 Hemopexin 0.0224 PF00107 Zinc-binding dehydrogenase 0.0217 PF00102 Protein-tyrosine phosphatase 0.0209 PF02798 Glutathione S-transferase, N-terminal domain 0.0203 PF00043 Glutathione S-transferase, C-terminal domain 0.0202 PF00413 Matrixin 0.0197 PF00962 Adenosine/AMP deaminase 0.0195 PF00017 SH2 domain 0.0191 PF02223 Thymidylate kinase 0.0189 PF00018 SH3 domain 0.0169 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0165 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0165 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0160 PF01431 Peptidase family M13 0.0160 PF05649 Peptidase family M13 0.0150 PF00106 short chain dehydrogenase 0.0129 PF08983 Domain of unknown function (DUF1856), 0.0127 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0119 PF08919 F-actin binding 0.0117 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0095 PF00005 ABC transporter 0.0092 PF00303 Thymidylate synthase 0.0089 PF00858 Amiloride-sensitive sodium channel 0.0086 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0079 PF01467 Cytidylyltransferase 0.0077 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0077 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0077 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0072 PF00255 Glutathione peroxidase 0.0067 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0062 PF00171 Aldehyde dehydrogenase family 0.0058 PF00051 Kringle domain 0.0057 PF00156 Phosphoribosyl transferase domain 0.0051 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0051 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0051 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0047 PF06512 Sodium ion transport-associated 0.0046 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0046 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0043 PF01268 Formate--tetrahydrofolate ligase 0.0041 PF00854 POT family 0.0037 PF00551 Formyl transferase 0.0029 PF01808 AICARFT/IMPCHase bienzyme 0.0017 PF00868 Transglutaminase family 0.0017 PF01841 Transglutaminase-like superfamily 0.0017 PF00927 Transglutaminase family, C-terminal ig like domain 0.0016 PF01687 Riboflavin kinase 0.0016 PF00026 Eukaryotic aspartyl protease 0.0016 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0016 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0016 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0015 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0014 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0014 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0013 PF01061 ABC-2 type transporter 0.0012 PF07966 A1 Propeptide 0.0012 PF02267 ADP-ribosyl cyclase 0.0012 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0012 PF01571 Aminomethyltransferase folate-binding domain 0.0009 PF00664 ABC transporter transmembrane region 0.0006 PF00089 Trypsin 0.0004 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF02769 AIR synthase related protein, C-terminal domain 0.0003 PF02036 SCP-2 sterol transfer family 0.0003 PF01575 MaoC like domain 0.0003 PF00586 AIR synthase related protein, N-terminal domain 0.0001 PF02142 MGS-like domain SUB491 C-C-C=C 0.1081 PF00001 7 transmembrane receptor (rhodopsin family), 0.0496 PF02159 Oestrogen receptor 0.0461 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0459 PF00105 Zinc finger, C4 type (two domains), 0.0456 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0438 PF03098 Animal haem peroxidase 0.0307 PF00209 Sodium:neurotransmitter symporter family 0.0212 PF06512 Sodium ion transport-associated 0.0210 PF08070 DTHCT (NUC029), region 0.0210 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0210 PF00204 DNA gyrase B 0.0166 PF00520 Ion transport protein 0.0128 PF03073 TspO/MBR family 0.0128 PF00191 Annexin 0.0122 PF02161 Progesterone receptor 0.0105 PF00194 Eukaryotic-type carbonic anhydrase 0.0099 PF00989 PAS fold 0.0095 PF09396 Thrombin light chain 0.0093 PF02155 Glucocorticoid receptor 0.0080 PF00067 Cytochrome P450 0.0080 PF00027 Cyclic nucleotide-binding domain 0.0059 PF01593 Flavin containing amine oxidoreductase 0.0042 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0036 PF00186 Dihydrofolate reductase 0.0034 PF01735 Lysophospholipase catalytic domain 0.0030 PF12497 Estrogen receptor beta 0.0030 PF01007 Inward rectifier potassium channel 0.0028 PF00305 Lipoxygenase 0.0023 PF00005 ABC transporter 0.0022 PF08403 Amino acid permease N-terminal 0.0017 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0017 PF00102 Protein-tyrosine phosphatase 0.0015 PF00576 HIUase/Transthyretin family 0.0010 PF00273 Serum albumin family 0.0009 PF00664 ABC transporter transmembrane region 0.0003 PF00091 Tubulin/FtsZ family, GTPase domain 0.0003 PF03953 Tubulin C-terminal domain 0.0003 PF07884 Vitamin K epoxide reductase family SUB557 C=C-C-C 0.1081 PF00001 7 transmembrane receptor (rhodopsin family), 0.0496 PF02159 Oestrogen receptor 0.0461 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0459 PF00105 Zinc finger, C4 type (two domains), 0.0456 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0438 PF03098 Animal haem peroxidase 0.0307 PF00209 Sodium:neurotransmitter symporter family 0.0212 PF06512 Sodium ion transport-associated 0.0210 PF00204 DNA gyrase B 0.0210 PF08070 DTHCT (NUC029), region 0.0210 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0166 PF00520 Ion transport protein 0.0128 PF00191 Annexin 0.0128 PF03073 TspO/MBR family 0.0122 PF02161 Progesterone receptor 0.0105 PF00194 Eukaryotic-type carbonic anhydrase 0.0099 PF00989 PAS fold 0.0095 PF09396 Thrombin light chain 0.0093 PF02155 Glucocorticoid receptor 0.0080 PF00027 Cyclic nucleotide-binding domain 0.0080 PF00067 Cytochrome P450 0.0059 PF01593 Flavin containing amine oxidoreductase 0.0042 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0036 PF00186 Dihydrofolate reductase 0.0034 PF01735 Lysophospholipase catalytic domain 0.0030 PF12497 Estrogen receptor beta 0.0030 PF01007 Inward rectifier potassium channel 0.0028 PF00305 Lipoxygenase 0.0023 PF00005 ABC transporter 0.0022 PF08403 Amino acid permease N-terminal 0.0017 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0017 PF00102 Protein-tyrosine phosphatase 0.0015 PF00576 HIUase/Transthyretin family 0.0010 PF00273 Serum albumin family 0.0009 PF00664 ABC transporter transmembrane region 0.0003 PF00091 Tubulin/FtsZ family, GTPase domain 0.0003 PF03953 Tubulin C-terminal domain 0.0003 PF07884 Vitamin K epoxide reductase family SUB490 N-C-S-C 0.1072 PF00091 Tubulin/FtsZ family, GTPase domain 0.1072 PF03953 Tubulin C-terminal domain 0.0456 PF00690 Cation transporter/ATPase, N-terminus 0.0456 PF00689 Cation transporting ATPase, C-terminus 0.0444 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0406 PF00122 E1-E2 ATPase 0.0365 PF00702 haloacid dehalogenase-like hydrolase 0.0160 PF00194 Eukaryotic-type carbonic anhydrase 0.0154 PF00018 SH3 domain 0.0142 PF07884 Vitamin K epoxide reductase family 0.0140 PF00017 SH2 domain 0.0132 PF01068 ATP dependent DNA ligase domain 0.0132 PF04679 ATP dependent DNA ligase C terminal region 0.0130 PF01770 Reduced folate carrier 0.0126 PF08919 F-actin binding 0.0124 PF00102 Protein-tyrosine phosphatase 0.0105 PF00287 Sodium / potassium ATPase beta chain 0.0093 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0090 PF00536 SAM domain (Sterile alpha motif), 0.0090 PF01404 Ephrin receptor ligand binding domain 0.0074 PF00854 POT family 0.0071 PF00478 IMP dehydrogenase / GMP reductase domain 0.0071 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0070 PF00146 NADH dehydrogenase 0.0062 PF01017 STAT protein, all-alpha domain 0.0062 PF02865 STAT protein, protein interaction domain 0.0062 PF02864 STAT protein, DNA binding domain 0.0061 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0059 PF00962 Adenosine/AMP deaminase 0.0050 PF00183 Hsp90 protein 0.0050 PF00377 Prion/Doppel alpha-helical domain 0.0050 PF00656 Caspase domain 0.0050 PF02059 Interleukin-3 0.0048 PF02394 Interleukin-1 propeptide 0.0048 PF00340 Interleukin-1 / 18 0.0045 PF00156 Phosphoribosyl transferase domain 0.0044 PF12497 Estrogen receptor beta 0.0044 PF10397 Adenylosuccinate lyase C-terminus 0.0038 PF00958 GMP synthase C terminal domain 0.0037 PF02214 K+ channel tetramerisation domain 0.0037 PF00230 Major intrinsic protein 0.0036 PF00069 Protein kinase domain 0.0035 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0035 PF01023 S-100/ICaBP type calcium binding domain 0.0035 PF02254 TrkA-N domain 0.0032 PF00020 TNFR/NGFR cysteine-rich region 0.0032 PF03098 Animal haem peroxidase 0.0028 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0028 PF00619 Caspase recruitment domain 0.0027 PF02525 Flavodoxin-like fold 0.0027 PF00206 Lyase 0.0027 PF00341 Platelet-derived growth factor (PDGF), 0.0026 PF00667 FAD binding domain 0.0026 PF00258 Flavodoxin 0.0026 PF00175 Oxidoreductase NAD-binding domain 0.0025 PF02898 Nitric oxide synthase, oxygenase domain 0.0025 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0024 PF00305 Lipoxygenase 0.0023 PF00273 Serum albumin family 0.0023 PF09396 Thrombin light chain 0.0023 PF00041 Fibronectin type III domain 0.0022 PF00040 Fibronectin type II domain 0.0020 PF00531 Death domain 0.0020 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0019 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0019 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0018 PF02155 Glucocorticoid receptor 0.0017 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0017 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0017 PF00631 GGL domain 0.0016 PF03073 TspO/MBR family 0.0016 PF01122 Eukaryotic cobalamin-binding protein 0.0015 PF02888 Calmodulin binding domain 0.0015 PF03530 Calcium-activated SK potassium channel 0.0014 PF00520 Ion transport protein 0.0014 PF00709 Adenylosuccinate synthetase 0.0014 PF00117 Glutamine amidotransferase class-I 0.0013 PF00001 7 transmembrane receptor (rhodopsin family), 0.0013 PF00245 Alkaline phosphatase 0.0013 PF00571 CBS domain 0.0012 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0011 PF03308 ArgK protein 0.0011 PF01642 Methylmalonyl-CoA mutase 0.0011 PF02310 B12 binding domain 0.0011 PF01923 Cobalamin adenosyltransferase 0.0010 PF00310 Glutamine amidotransferases class-II 0.0010 PF01477 PLAT/LH2 domain 0.0010 PF01687 Riboflavin kinase 0.0009 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0009 PF00792 Phosphoinositide 3-kinase C2 0.0009 PF00794 PI3-kinase family, ras-binding domain 0.0008 PF07678 A-macroglobulin complement component 0.0008 PF07677 A-macroglobulin receptor 0.0008 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0008 PF01835 MG2 domain 0.0008 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0007 PF08403 Amino acid permease N-terminal 0.0007 PF01425 Amidase 0.0006 PF02441 Flavoprotein 0.0006 PF01403 Sema domain 0.0006 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0006 PF01437 Plexin repeat 0.0006 PF01833 IPT/TIG domain 0.0006 PF00191 Annexin 0.0006 PF00060 Ligand-gated ion channel 0.0006 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0005 PF00654 Voltage gated chloride channel 0.0005 PF08377 MAP2/Tau projection domain 0.0005 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0005 PF01731 Arylesterase 0.0005 PF00489 Interleukin-6/G-CSF/MGF family 0.0005 PF00576 HIUase/Transthyretin family 0.0005 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0005 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0005 PF07885 Ion channel 0.0005 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0004 PF00625 Guanylate kinase 0.0004 PF00405 Transferrin 0.0004 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0004 PF00970 Oxidoreductase FAD-binding domain 0.0004 PF00459 Inositol monophosphatase family 0.0003 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0003 PF02828 L27 domain 0.0003 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0003 PF07970 Endoplasmic reticulum vesicle transporter 0.0003 PF00514 Armadillo/beta-catenin-like repeat 0.0003 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0003 PF01180 Dihydroorotate dehydrogenase 0.0003 PF05406 WGR domain 0.0003 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0003 PF02607 B12 binding domain 0.0003 PF03454 MoeA C-terminal region (domain IV), 0.0003 PF03453 MoeA N-terminal region (domain I and II), 0.0003 PF02984 Cyclin, C-terminal domain 0.0003 PF00134 Cyclin, N-terminal domain 0.0003 PF00533 BRCA1 C Terminus (BRCT), domain 0.0003 PF00994 Probable molybdopterin binding domain 0.0003 PF00779 BTK motif 0.0003 PF08063 PADR1 (NUC008), domain 0.0003 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0003 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0003 PF01007 Inward rectifier potassium channel 0.0003 PF12126 Protein of unknown function (DUF3583), 0.0003 PF00809 Pterin binding enzyme 0.0003 PF01094 Receptor family ligand binding region 0.0003 PF02196 Raf-like Ras-binding domain 0.0003 PF00431 CUB domain 0.0003 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0003 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0002 PF08399 VWA N-terminal 0.0002 PF02743 Cache domain 0.0002 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0002 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0002 PF00303 Thymidylate synthase 0.0002 PF01369 Sec7 domain 0.0002 PF00675 Insulinase (Peptidase family M16), 0.0002 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0002 PF05193 Peptidase M16 inactive domain 0.0002 PF00089 Trypsin 0.0002 PF00989 PAS fold 0.0001 PF00027 Cyclic nucleotide-binding domain 0.0001 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0001 PF07653 Variant SH3 domain 0.0001 PF00557 Metallopeptidase family M24 0.0001 PF08763 Voltage gated calcium channel IQ domain 0.0001 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0001 PF00406 Adenylate kinase 0.0001 PF00042 Globin 0.0001 PF00581 Rhodanese-like domain 0.0001 PF06617 M-phase inducer phosphatase 0.0001 PF00462 Glutaredoxin 0.0001 PF02189 Immunoreceptor tyrosine-based activation motif 0.0001 PF11857 Domain of unknown function (DUF3377), 0.0001 PF02038 ATP1G1/PLM/MAT8 family 0.0001 PF01733 Nucleoside transporter 0.0001 PF03957 Jun-like transcription factor SUB407 O(~C)(~H) 0.1065 PF03098 Animal haem peroxidase 0.0848 PF00273 Serum albumin family 0.0834 PF00204 DNA gyrase B 0.0834 PF08070 DTHCT (NUC029), region 0.0834 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0650 PF00191 Annexin 0.0638 PF02155 Glucocorticoid receptor 0.0598 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0559 PF00105 Zinc finger, C4 type (two domains), 0.0552 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0511 PF01401 Angiotensin-converting enzyme 0.0466 PF00576 HIUase/Transthyretin family 0.0407 PF00102 Protein-tyrosine phosphatase 0.0354 PF00079 Serpin (serine protease inhibitor), 0.0349 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0285 PF01063 Aminotransferase class IV 0.0233 PF02159 Oestrogen receptor 0.0226 PF00091 Tubulin/FtsZ family, GTPase domain 0.0226 PF03953 Tubulin C-terminal domain 0.0215 PF00155 Aminotransferase class I and II 0.0202 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0150 PF01842 ACT domain 0.0136 PF00557 Metallopeptidase family M24 0.0132 PF00202 Aminotransferase class-III 0.0128 PF00303 Thymidylate synthase 0.0128 PF02806 Alpha amylase, C-terminal all-beta domain 0.0122 PF01735 Lysophospholipase catalytic domain 0.0112 PF02166 Androgen receptor 0.0073 PF00128 Alpha amylase, catalytic domain 0.0064 PF01268 Formate--tetrahydrofolate ligase 0.0059 PF00464 Serine hydroxymethyltransferase 0.0051 PF01126 Heme oxygenase 0.0050 PF05649 Peptidase family M13 0.0050 PF01431 Peptidase family M13 0.0049 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0049 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0038 PF03414 Glycosyltransferase family 6 0.0038 PF00248 Aldo/keto reductase family 0.0022 PF00175 Oxidoreductase NAD-binding domain 0.0021 PF00291 Pyridoxal-phosphate dependent enzyme 0.0017 PF00733 Asparagine synthase 0.0016 PF02898 Nitric oxide synthase, oxygenase domain 0.0012 PF00571 CBS domain 0.0011 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0011 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0011 PF00071 Ras family 0.0009 PF07706 Aminotransferase ubiquitination site 0.0009 PF03171 2OG-Fe(II), oxygenase superfamily 0.0009 PF00266 Aminotransferase class-V 0.0008 PF00667 FAD binding domain 0.0008 PF00258 Flavodoxin 0.0006 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0006 PF02798 Glutathione S-transferase, N-terminal domain 0.0002 PF00043 Glutathione S-transferase, C-terminal domain SUB66 >= 1 As 0.1063 PF07970 Endoplasmic reticulum vesicle transporter 0.1063 PF00134 Cyclin, N-terminal domain 0.1063 PF12126 Protein of unknown function (DUF3583), 0.1063 PF02984 Cyclin, C-terminal domain 0.1061 PF12179 I-kappa-kinase-beta NEMO binding domain 0.1059 PF00489 Interleukin-6/G-CSF/MGF family 0.1058 PF03957 Jun-like transcription factor 0.0732 PF00170 bZIP transcription factor 0.0627 PF00690 Cation transporter/ATPase, N-terminus 0.0627 PF00689 Cation transporting ATPase, C-terminus 0.0592 PF00643 B-box zinc finger 0.0582 PF00069 Protein kinase domain 0.0555 PF00122 E1-E2 ATPase 0.0498 PF00702 haloacid dehalogenase-like hydrolase 0.0410 PF00433 Protein kinase C terminal domain 0.0271 PF00169 PH domain 0.0269 PF00664 ABC transporter transmembrane region 0.0220 PF00005 ABC transporter 0.0150 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0147 PF00146 NADH dehydrogenase 0.0145 PF01161 Phosphatidylethanolamine-binding protein 0.0129 PF00459 Inositol monophosphatase family 0.0113 PF00405 Transferrin 0.0102 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0100 PF00194 Eukaryotic-type carbonic anhydrase 0.0089 PF03160 Calx-beta domain 0.0080 PF00581 Rhodanese-like domain 0.0080 PF06617 M-phase inducer phosphatase 0.0078 PF00324 Amino acid permease 0.0077 PF02214 K+ channel tetramerisation domain 0.0076 PF00625 Guanylate kinase 0.0069 PF00514 Armadillo/beta-catenin-like repeat 0.0067 PF00576 HIUase/Transthyretin family 0.0055 PF02828 L27 domain 0.0055 PF00994 Probable molybdopterin binding domain 0.0055 PF03453 MoeA N-terminal region (domain I and II), 0.0055 PF03454 MoeA C-terminal region (domain IV), 0.0053 PF01369 Sec7 domain 0.0050 PF00822 PMP-22/EMP/MP20/Claudin family 0.0049 PF08403 Amino acid permease N-terminal 0.0048 PF00362 Integrin, beta chain 0.0048 PF07965 Integrin beta tail domain 0.0044 PF00248 Aldo/keto reductase family 0.0043 PF00211 Adenylate and Guanylate cyclase catalytic domain 0.0043 PF00317 Ribonucleotide reductase, all-alpha domain 0.0043 PF02867 Ribonucleotide reductase, barrel domain 0.0043 PF03477 ATP cone domain 0.0036 PF00273 Serum albumin family 0.0035 PF00107 Zinc-binding dehydrogenase 0.0034 PF08240 Alcohol dehydrogenase GroES-like domain 0.0032 PF00041 Fibronectin type III domain 0.0032 PF03949 Malic enzyme, NAD binding domain 0.0032 PF00390 Malic enzyme, N-terminal domain 0.0030 PF00854 POT family 0.0027 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0027 PF07653 Variant SH3 domain 0.0027 PF02743 Cache domain 0.0027 PF08399 VWA N-terminal 0.0023 PF08763 Voltage gated calcium channel IQ domain 0.0022 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0022 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0014 PF00595 PDZ domain (Also known as DHR or GLGF), 0.0012 PF00167 Fibroblast growth factor 0.0011 PF00821 Phosphoenolpyruvate carboxykinase 0.0011 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0011 PF00631 GGL domain 0.0011 PF00153 Mitochondrial carrier protein 0.0010 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0009 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0009 PF02180 Bcl-2 homology region 4 0.0008 PF00858 Amiloride-sensitive sodium channel 0.0007 PF09127 Leukotriene A4 hydrolase, C-terminal 0.0007 PF08674 Acetylcholinesterase tetramerisation domain 0.0005 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0005 PF02254 TrkA-N domain 0.0005 PF03530 Calcium-activated SK potassium channel 0.0005 PF02888 Calmodulin binding domain 0.0002 PF00303 Thymidylate synthase 0.0001 PF00156 Phosphoribosyl transferase domain SUB565 C=C-C=C 0.1053 PF00001 7 transmembrane receptor (rhodopsin family), 0.0497 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0352 PF00209 Sodium:neurotransmitter symporter family 0.0316 PF03098 Animal haem peroxidase 0.0269 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0269 PF00204 DNA gyrase B 0.0269 PF08070 DTHCT (NUC029), region 0.0237 PF06512 Sodium ion transport-associated 0.0224 PF00194 Eukaryotic-type carbonic anhydrase 0.0200 PF03073 TspO/MBR family 0.0197 PF00520 Ion transport protein 0.0124 PF00989 PAS fold 0.0107 PF00102 Protein-tyrosine phosphatase 0.0103 PF09396 Thrombin light chain 0.0102 PF00027 Cyclic nucleotide-binding domain 0.0092 PF00186 Dihydrofolate reductase 0.0084 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0074 PF01593 Flavin containing amine oxidoreductase 0.0073 PF00576 HIUase/Transthyretin family 0.0064 PF00005 ABC transporter 0.0057 PF08403 Amino acid permease N-terminal 0.0053 PF01007 Inward rectifier potassium channel 0.0048 PF03953 Tubulin C-terminal domain 0.0048 PF00091 Tubulin/FtsZ family, GTPase domain 0.0041 PF00664 ABC transporter transmembrane region 0.0039 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0035 PF00069 Protein kinase domain 0.0025 PF01431 Peptidase family M13 0.0025 PF05649 Peptidase family M13 0.0024 PF07884 Vitamin K epoxide reductase family 0.0022 PF00017 SH2 domain 0.0017 PF02254 TrkA-N domain 0.0017 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0015 PF02159 Oestrogen receptor 0.0014 PF01401 Angiotensin-converting enzyme 0.0011 PF00018 SH3 domain 0.0009 PF00822 PMP-22/EMP/MP20/Claudin family 0.0008 PF08983 Domain of unknown function (DUF1856), 0.0008 PF12497 Estrogen receptor beta 0.0005 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0005 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0003 PF00042 Globin 0.0003 PF01061 ABC-2 type transporter 0.0001 PF00067 Cytochrome P450 SUB593 N-C-C-C-C 0.1053 PF00001 7 transmembrane receptor (rhodopsin family), 0.0420 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0347 PF00209 Sodium:neurotransmitter symporter family 0.0250 PF03073 TspO/MBR family 0.0205 PF01401 Angiotensin-converting enzyme 0.0149 PF00005 ABC transporter 0.0128 PF00664 ABC transporter transmembrane region 0.0122 PF00989 PAS fold 0.0108 PF00186 Dihydrofolate reductase 0.0103 PF00027 Cyclic nucleotide-binding domain 0.0101 PF02223 Thymidylate kinase 0.0087 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0083 PF01048 Phosphorylase superfamily 0.0071 PF00069 Protein kinase domain 0.0068 PF06512 Sodium ion transport-associated 0.0062 PF05649 Peptidase family M13 0.0062 PF01431 Peptidase family M13 0.0053 PF00520 Ion transport protein 0.0048 PF00017 SH2 domain 0.0047 PF02180 Bcl-2 homology region 4 0.0047 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0043 PF02267 ADP-ribosyl cyclase 0.0043 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0043 PF08983 Domain of unknown function (DUF1856), 0.0037 PF01007 Inward rectifier potassium channel 0.0027 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0025 PF01842 ACT domain 0.0024 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0024 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0023 PF00464 Serine hydroxymethyltransferase 0.0021 PF01061 ABC-2 type transporter 0.0020 PF01467 Cytidylyltransferase 0.0019 PF00255 Glutathione peroxidase 0.0019 PF00018 SH3 domain 0.0018 PF00303 Thymidylate synthase 0.0018 PF02798 Glutathione S-transferase, N-terminal domain 0.0017 PF08919 F-actin binding 0.0017 PF01234 NNMT/PNMT/TEMT family 0.0017 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0017 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0015 PF00043 Glutathione S-transferase, C-terminal domain 0.0014 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0014 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0012 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0010 PF01590 GAF domain 0.0010 PF03807 NADP oxidoreductase coenzyme F420-dependent 0.0010 PF00551 Formyl transferase 0.0008 PF08491 Squalene epoxidase 0.0006 PF08441 Integrin alpha 0.0006 PF01055 Glycosyl hydrolases family 31 0.0006 PF00088 Trefoil (P-type), domain 0.0005 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0005 PF09396 Thrombin light chain 0.0004 PF05406 WGR domain 0.0004 PF07966 A1 Propeptide 0.0004 PF01808 AICARFT/IMPCHase bienzyme 0.0004 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0004 PF01687 Riboflavin kinase 0.0004 PF00533 BRCA1 C Terminus (BRCT), domain 0.0004 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0004 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0004 PF02173 pKID domain 0.0004 PF08063 PADR1 (NUC008), domain 0.0003 PF00026 Eukaryotic aspartyl protease 0.0003 PF08403 Amino acid permease N-terminal 0.0003 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0003 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0003 PF00357 Integrin alpha cytoplasmic region 0.0003 PF01122 Eukaryotic cobalamin-binding protein 0.0003 PF01571 Aminomethyltransferase folate-binding domain 0.0003 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0003 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0003 PF01426 BAH domain 0.0003 PF06464 DMAP1-binding Domain 0.0003 PF02008 CXXC zinc finger domain 0.0003 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0001 PF00755 Choline/Carnitine o-acyltransferase 0.0001 PF00204 DNA gyrase B 0.0001 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0001 PF08070 DTHCT (NUC029), region 0.0001 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0001 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0001 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0001 PF01268 Formate--tetrahydrofolate ligase SUB544 O-C:C-N 0.1052 PF00155 Aminotransferase class I and II 0.1009 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0996 PF00266 Aminotransferase class-V 0.0737 PF00464 Serine hydroxymethyltransferase 0.0658 PF00291 Pyridoxal-phosphate dependent enzyme 0.0627 PF00202 Aminotransferase class-III 0.0597 PF01063 Aminotransferase class IV 0.0579 PF00343 Carbohydrate phosphorylase 0.0487 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0487 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0415 PF00294 pfkB family carbohydrate kinase 0.0367 PF00702 haloacid dehalogenase-like hydrolase 0.0365 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0365 PF00204 DNA gyrase B 0.0365 PF08070 DTHCT (NUC029), region 0.0244 PF03476 MOSC N-terminal beta barrel domain 0.0244 PF03473 MOSC domain 0.0244 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0243 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0243 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0240 PF02347 Glycine cleavage system P-protein 0.0240 PF01202 Shikimate kinase 0.0240 PF01168 Alanine racemase, N-terminal domain 0.0240 PF01212 Beta-eliminating lyase 0.0240 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0236 PF02971 Formiminotransferase domain 0.0236 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0236 PF04961 Formiminotransferase-cyclodeaminase 0.0231 PF07706 Aminotransferase ubiquitination site 0.0177 PF01596 O-methyltransferase 0.0151 PF00571 CBS domain 0.0138 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0124 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0124 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0103 PF00576 HIUase/Transthyretin family 0.0100 PF00690 Cation transporter/ATPase, N-terminus 0.0100 PF00689 Cation transporting ATPase, C-terminus 0.0081 PF00122 E1-E2 ATPase 0.0079 PF01735 Lysophospholipase catalytic domain 0.0065 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0063 PF00989 PAS fold 0.0061 PF00340 Interleukin-1 / 18 0.0061 PF02394 Interleukin-1 propeptide 0.0060 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0056 PF00191 Annexin 0.0054 PF00342 Phosphoglucose isomerase 0.0051 PF00102 Protein-tyrosine phosphatase 0.0050 PF00194 Eukaryotic-type carbonic anhydrase 0.0050 PF00027 Cyclic nucleotide-binding domain 0.0050 PF02155 Glucocorticoid receptor 0.0049 PF03073 TspO/MBR family 0.0047 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0043 PF00520 Ion transport protein 0.0043 PF02166 Androgen receptor 0.0040 PF01588 Putative tRNA binding domain 0.0039 PF00303 Thymidylate synthase 0.0038 PF03477 ATP cone domain 0.0038 PF00317 Ribonucleotide reductase, all-alpha domain 0.0038 PF02867 Ribonucleotide reductase, barrel domain 0.0037 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0037 PF00079 Serpin (serine protease inhibitor), 0.0035 PF01916 Deoxyhypusine synthase 0.0033 PF00146 NADH dehydrogenase 0.0031 PF01180 Dihydroorotate dehydrogenase 0.0030 PF02214 K+ channel tetramerisation domain 0.0029 PF00168 C2 domain 0.0027 PF00757 Furin-like cysteine rich region 0.0027 PF01030 Receptor L domain 0.0025 PF08996 DNA Polymerase alpha zinc finger 0.0025 PF03104 DNA polymerase family B, exonuclease domain 0.0025 PF00136 DNA polymerase family B 0.0023 PF03098 Animal haem peroxidase 0.0022 PF00248 Aldo/keto reductase family 0.0022 PF00493 MCM2/3/5 family 0.0021 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0019 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0018 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0016 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0016 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0016 PF00028 Cadherin domain 0.0016 PF05406 WGR domain 0.0016 PF08063 PADR1 (NUC008), domain 0.0016 PF00533 BRCA1 C Terminus (BRCT), domain 0.0015 PF02460 Patched family 0.0015 PF00069 Protein kinase domain 0.0014 PF00149 Calcineurin-like phosphoesterase 0.0014 PF03062 MBOAT family 0.0013 PF00654 Voltage gated chloride channel 0.0012 PF12491 Apolipoprotein B100 C terminal 0.0012 PF06448 Domain of Unknown Function (DUF1081), 0.0011 PF00489 Interleukin-6/G-CSF/MGF family 0.0011 PF02196 Raf-like Ras-binding domain 0.0010 PF00229 TNF(Tumour Necrosis Factor), family 0.0010 PF01731 Arylesterase 0.0008 PF02180 Bcl-2 homology region 4 0.0008 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0007 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0006 PF01347 Lipoprotein amino terminal region 0.0005 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0004 PF00554 Rel homology domain (RHD), 0.0004 PF00042 Globin 0.0004 PF00058 Low-density lipoprotein receptor repeat class B 0.0004 PF00406 Adenylate kinase 0.0003 PF02864 STAT protein, DNA binding domain 0.0003 PF02865 STAT protein, protein interaction domain 0.0003 PF08403 Amino acid permease N-terminal 0.0003 PF00432 Prenyltransferase and squalene oxidase repeat 0.0003 PF01017 STAT protein, all-alpha domain 0.0003 PF01391 Collagen triple helix repeat (20 copies), 0.0003 PF09396 Thrombin light chain 0.0002 PF01061 ABC-2 type transporter 0.0002 PF00071 Ras family 0.0002 PF00821 Phosphoenolpyruvate carboxykinase 0.0001 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0001 PF00341 Platelet-derived growth factor (PDGF), 0.0001 PF01433 Peptidase family M1 0.0001 PF00656 Caspase domain 0.0001 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region SUB449 C(-H)(=O) 0.1043 PF00155 Aminotransferase class I and II 0.1000 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0988 PF00266 Aminotransferase class-V 0.0731 PF00464 Serine hydroxymethyltransferase 0.0653 PF00291 Pyridoxal-phosphate dependent enzyme 0.0621 PF00202 Aminotransferase class-III 0.0592 PF01063 Aminotransferase class IV 0.0575 PF00343 Carbohydrate phosphorylase 0.0482 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0482 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0412 PF00294 pfkB family carbohydrate kinase 0.0327 PF00702 haloacid dehalogenase-like hydrolase 0.0242 PF03476 MOSC N-terminal beta barrel domain 0.0242 PF03473 MOSC domain 0.0242 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0241 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0241 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0238 PF01168 Alanine racemase, N-terminal domain 0.0238 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0238 PF01212 Beta-eliminating lyase 0.0238 PF01202 Shikimate kinase 0.0238 PF02347 Glycine cleavage system P-protein 0.0234 PF02971 Formiminotransferase domain 0.0234 PF04961 Formiminotransferase-cyclodeaminase 0.0234 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0229 PF07706 Aminotransferase ubiquitination site 0.0173 PF01596 O-methyltransferase 0.0150 PF00571 CBS domain 0.0060 PF02394 Interleukin-1 propeptide 0.0060 PF00340 Interleukin-1 / 18 0.0054 PF00342 Phosphoglucose isomerase 0.0049 PF00689 Cation transporting ATPase, C-terminus 0.0049 PF00690 Cation transporter/ATPase, N-terminus 0.0040 PF01588 Putative tRNA binding domain 0.0039 PF00576 HIUase/Transthyretin family 0.0036 PF00122 E1-E2 ATPase 0.0034 PF01916 Deoxyhypusine synthase 0.0020 PF00204 DNA gyrase B 0.0020 PF08070 DTHCT (NUC029), region 0.0020 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0018 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0014 PF00149 Calcineurin-like phosphoesterase SUB799 CC1CC(O)CCC1 0.1041 PF00191 Annexin 0.0910 PF02155 Glucocorticoid receptor 0.0502 PF01735 Lysophospholipase catalytic domain 0.0477 PF00079 Serpin (serine protease inhibitor), 0.0437 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0432 PF00105 Zinc finger, C4 type (two domains), 0.0393 PF00204 DNA gyrase B 0.0393 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0393 PF08070 DTHCT (NUC029), region 0.0271 PF02159 Oestrogen receptor 0.0225 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0188 PF00168 C2 domain 0.0181 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0155 PF00091 Tubulin/FtsZ family, GTPase domain 0.0155 PF03953 Tubulin C-terminal domain 0.0146 PF00001 7 transmembrane receptor (rhodopsin family), 0.0134 PF00102 Protein-tyrosine phosphatase 0.0103 PF00557 Metallopeptidase family M24 0.0097 PF02161 Progesterone receptor 0.0095 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0095 PF02180 Bcl-2 homology region 4 0.0094 PF08384 Pro-opiomelanocortin, N-terminal region 0.0094 PF00976 Corticotropin ACTH domain 0.0094 PF08035 Opioids neuropeptide 0.0089 PF12497 Estrogen receptor beta 0.0088 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0084 PF00554 Rel homology domain (RHD), 0.0075 PF02166 Androgen receptor 0.0074 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0073 PF00229 TNF(Tumour Necrosis Factor), family 0.0070 PF00183 Hsp90 protein 0.0064 PF00005 ABC transporter 0.0059 PF00664 ABC transporter transmembrane region 0.0056 PF03062 MBOAT family 0.0053 PF02173 pKID domain 0.0050 PF01477 PLAT/LH2 domain 0.0045 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0045 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0043 PF07690 Major Facilitator Superfamily 0.0037 PF00170 bZIP transcription factor 0.0033 PF00656 Caspase domain 0.0032 PF08771 Rapamycin binding domain 0.0032 PF01347 Lipoprotein amino terminal region 0.0032 PF00151 Lipase 0.0032 PF02259 FAT domain 0.0032 PF02260 FATC domain 0.0030 PF03171 2OG-Fe(II), oxygenase superfamily 0.0030 PF00341 Platelet-derived growth factor (PDGF), 0.0029 PF07648 Kazal-type serine protease inhibitor domain 0.0028 PF00305 Lipoxygenase 0.0027 PF00531 Death domain 0.0027 PF01401 Angiotensin-converting enzyme 0.0026 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0025 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0025 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0024 PF09396 Thrombin light chain 0.0023 PF02025 Interleukin 5 0.0023 PF00094 von Willebrand factor type D domain 0.0023 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0023 PF02525 Flavodoxin-like fold 0.0023 PF08742 C8 domain 0.0022 PF07884 Vitamin K epoxide reductase family 0.0021 PF00176 SNF2 family N-terminal domain 0.0020 PF00271 Helicase conserved C-terminal domain 0.0019 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0019 PF08659 KR domain 0.0019 PF00698 Acyl transferase domain 0.0019 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0019 PF00975 Thioesterase domain 0.0018 PF00432 Prenyltransferase and squalene oxidase repeat 0.0018 PF00989 PAS fold 0.0017 PF00493 MCM2/3/5 family 0.0016 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0015 PF01596 O-methyltransferase 0.0014 PF00186 Dihydrofolate reductase 0.0013 PF01061 ABC-2 type transporter 0.0013 PF00027 Cyclic nucleotide-binding domain 0.0013 PF02758 PAAD/DAPIN/Pyrin domain 0.0012 PF00340 Interleukin-1 / 18 0.0012 PF02394 Interleukin-1 propeptide 0.0012 PF01391 Collagen triple helix repeat (20 copies), 0.0012 PF00023 Ankyrin repeat 0.0011 PF00224 Pyruvate kinase, barrel domain 0.0011 PF03360 Glycosyltransferase family 43 0.0011 PF02887 Pyruvate kinase, alpha/beta domain 0.0010 PF00489 Interleukin-6/G-CSF/MGF family 0.0010 PF00643 B-box zinc finger 0.0010 PF00167 Fibroblast growth factor 0.0010 PF00377 Prion/Doppel alpha-helical domain 0.0010 PF00040 Fibronectin type II domain 0.0010 PF00067 Cytochrome P450 0.0008 PF02460 Patched family 0.0008 PF00042 Globin 0.0008 PF00354 Pentaxin family 0.0008 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0008 PF00274 Fructose-bisphosphate aldolase class-I 0.0007 PF11825 Protein of unknown function (DUF3345), 0.0007 PF00051 Kringle domain 0.0006 PF06448 Domain of Unknown Function (DUF1081), 0.0006 PF12491 Apolipoprotein B100 C terminal 0.0006 PF00071 Ras family 0.0006 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0006 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0006 PF00969 Class II histocompatibility antigen, beta domain 0.0006 PF03623 Focal adhesion targeting region 0.0005 PF00622 SPRY domain 0.0005 PF01023 S-100/ICaBP type calcium binding domain 0.0004 PF04622 ERG2 and Sigma1 receptor like protein 0.0004 PF00074 Pancreatic ribonuclease 0.0003 PF06327 Domain of Unknown Function (DUF1053), 0.0003 PF00342 Phosphoglucose isomerase 0.0002 PF08441 Integrin alpha 0.0002 PF07885 Ion channel 0.0002 PF00357 Integrin alpha cytoplasmic region 0.0002 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0002 PF03765 CRAL/TRIO, N-terminus 0.0002 PF00650 CRAL/TRIO domain 0.0001 PF00550 Phosphopantetheine attachment site 0.0001 PF00212 Atrial natriuretic peptide SUB618 C-C-C-O-[#1] 0.1040 PF03098 Animal haem peroxidase 0.0830 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0830 PF08070 DTHCT (NUC029), region 0.0830 PF00204 DNA gyrase B 0.0828 PF00273 Serum albumin family 0.0636 PF00191 Annexin 0.0627 PF02155 Glucocorticoid receptor 0.0584 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0546 PF00105 Zinc finger, C4 type (two domains), 0.0539 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0499 PF01401 Angiotensin-converting enzyme 0.0456 PF00576 HIUase/Transthyretin family 0.0398 PF00102 Protein-tyrosine phosphatase 0.0354 PF00079 Serpin (serine protease inhibitor), 0.0349 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0279 PF01063 Aminotransferase class IV 0.0228 PF02159 Oestrogen receptor 0.0221 PF00091 Tubulin/FtsZ family, GTPase domain 0.0221 PF03953 Tubulin C-terminal domain 0.0210 PF00155 Aminotransferase class I and II 0.0197 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0148 PF02806 Alpha amylase, C-terminal all-beta domain 0.0147 PF01842 ACT domain 0.0133 PF00557 Metallopeptidase family M24 0.0129 PF00202 Aminotransferase class-III 0.0125 PF00303 Thymidylate synthase 0.0123 PF01735 Lysophospholipase catalytic domain 0.0109 PF02166 Androgen receptor 0.0090 PF00128 Alpha amylase, catalytic domain 0.0063 PF01268 Formate--tetrahydrofolate ligase 0.0058 PF00464 Serine hydroxymethyltransferase 0.0055 PF03414 Glycosyltransferase family 6 0.0050 PF01126 Heme oxygenase 0.0049 PF05649 Peptidase family M13 0.0049 PF01431 Peptidase family M13 0.0048 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0048 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0037 PF00248 Aldo/keto reductase family 0.0021 PF00291 Pyridoxal-phosphate dependent enzyme 0.0021 PF00175 Oxidoreductase NAD-binding domain 0.0016 PF00733 Asparagine synthase 0.0016 PF02898 Nitric oxide synthase, oxygenase domain 0.0012 PF00571 CBS domain 0.0011 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0011 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0010 PF03171 2OG-Fe(II), oxygenase superfamily 0.0010 PF00071 Ras family 0.0008 PF00667 FAD binding domain 0.0008 PF00258 Flavodoxin 0.0008 PF07706 Aminotransferase ubiquitination site 0.0008 PF00059 Lectin C-type domain 0.0008 PF00266 Aminotransferase class-V 0.0007 PF00084 Sushi domain (SCR repeat), 0.0007 PF00167 Fibroblast growth factor 0.0006 PF07654 Immunoglobulin C1-set domain 0.0006 PF00143 Interferon alpha/beta domain 0.0006 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0005 PF08702 Fibrinogen alpha/beta chain family 0.0005 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0005 PF02798 Glutathione S-transferase, N-terminal domain 0.0004 PF12160 Fibrinogen alpha C domain 0.0003 PF03727 Hexokinase 0.0003 PF02267 ADP-ribosyl cyclase 0.0003 PF02065 Melibiase 0.0003 PF00088 Trefoil (P-type), domain 0.0003 PF00293 NUDIX domain 0.0003 PF00328 Histidine acid phosphatase 0.0003 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0003 PF00349 Hexokinase 0.0003 PF00337 Galactoside-binding lectin 0.0003 PF07686 Immunoglobulin V-set domain 0.0003 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0003 PF01055 Glycosyl hydrolases family 31 0.0002 PF01370 NAD dependent epimerase/dehydratase family 0.0002 PF04679 ATP dependent DNA ligase C terminal region 0.0002 PF01068 ATP dependent DNA ligase domain 0.0002 PF00690 Cation transporter/ATPase, N-terminus 0.0002 PF00043 Glutathione S-transferase, C-terminal domain 0.0002 PF00041 Fibronectin type III domain 0.0002 PF00431 CUB domain 0.0002 PF07645 Calcium-binding EGF domain 0.0002 PF00689 Cation transporting ATPase, C-terminus 0.0002 PF00122 E1-E2 ATPase 0.0002 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0002 PF00089 Trypsin 0.0001 PF02055 O-Glycosyl hydrolase family 30 0.0001 PF04711 Apolipoprotein A-II (ApoA-II), 0.0001 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0001 PF00090 Thrombospondin type 1 domain 0.0001 PF00403 Heavy-metal-associated domain 0.0001 PF00093 von Willebrand factor type C domain 0.0001 PF00236 Glycoprotein hormone 0.0001 PF00702 haloacid dehalogenase-like hydrolase 0.0001 PF00703 domain 0.0001 PF01869 BadF/BadG/BcrA/BcrD ATPase family 0.0001 PF01532 Glycosyl hydrolase family 47 0.0001 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0001 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 0.0001 PF01562 Reprolysin family propeptide 0.0001 PF05735 Thrombospondin C-terminal region 0.0001 PF07648 Kazal-type serine protease inhibitor domain 0.0001 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0001 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0001 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0001 PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), 0.0001 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0001 PF00031 Cystatin domain 0.0001 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0001 PF00021 u-PAR/Ly-6 domain 0.0001 PF00057 Low-density lipoprotein receptor domain class A 0.0001 PF00058 Low-density lipoprotein receptor repeat class B 0.0001 PF00024 PAN domain 0.0001 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0001 PF08516 ADAM cysteine-rich 0.0001 PF00200 Disintegrin 0.0001 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0001 PF00884 Sulfatase 0.0001 PF00385 chromo (CHRromatin Organisation MOdifier), domain SUB689 C-C-C-C-C-C-C 0.1032 PF00001 7 transmembrane receptor (rhodopsin family), 0.0549 PF00105 Zinc finger, C4 type (two domains), 0.0547 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0527 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0486 PF02159 Oestrogen receptor 0.0320 PF00209 Sodium:neurotransmitter symporter family 0.0254 PF03098 Animal haem peroxidase 0.0183 PF08070 DTHCT (NUC029), region 0.0183 PF00204 DNA gyrase B 0.0183 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0106 PF00989 PAS fold 0.0094 PF03953 Tubulin C-terminal domain 0.0094 PF00091 Tubulin/FtsZ family, GTPase domain 0.0093 PF09396 Thrombin light chain 0.0086 PF00005 ABC transporter 0.0084 PF00027 Cyclic nucleotide-binding domain 0.0077 PF00067 Cytochrome P450 0.0066 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0063 PF00664 ABC transporter transmembrane region 0.0062 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0039 PF03073 TspO/MBR family 0.0033 PF02161 Progesterone receptor 0.0030 PF01593 Flavin containing amine oxidoreductase 0.0028 PF06512 Sodium ion transport-associated 0.0027 PF00273 Serum albumin family 0.0018 PF12497 Estrogen receptor beta 0.0017 PF11825 Protein of unknown function (DUF3345), 0.0013 PF00191 Annexin 0.0012 PF02166 Androgen receptor 0.0011 PF00520 Ion transport protein 0.0008 PF02155 Glucocorticoid receptor 0.0006 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0004 PF00186 Dihydrofolate reductase 0.0003 PF01007 Inward rectifier potassium channel 0.0002 PF01735 Lysophospholipase catalytic domain 0.0001 PF00017 SH2 domain SUB586 C-C:C-N-C 0.1028 PF03073 TspO/MBR family 0.1024 PF00194 Eukaryotic-type carbonic anhydrase 0.0796 PF00186 Dihydrofolate reductase 0.0574 PF00069 Protein kinase domain 0.0442 PF01048 Phosphorylase superfamily 0.0418 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0414 PF00001 7 transmembrane receptor (rhodopsin family), 0.0397 PF08403 Amino acid permease N-terminal 0.0352 PF08070 DTHCT (NUC029), region 0.0352 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0352 PF00204 DNA gyrase B 0.0302 PF06512 Sodium ion transport-associated 0.0242 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0242 PF02254 TrkA-N domain 0.0205 PF00005 ABC transporter 0.0193 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0155 PF00478 IMP dehydrogenase / GMP reductase domain 0.0140 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0137 PF01126 Heme oxygenase 0.0119 PF00962 Adenosine/AMP deaminase 0.0108 PF01061 ABC-2 type transporter 0.0108 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0104 PF00017 SH2 domain 0.0099 PF00520 Ion transport protein 0.0094 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0094 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0091 PF00018 SH3 domain 0.0086 PF01590 GAF domain 0.0080 PF00664 ABC transporter transmembrane region 0.0067 PF00571 CBS domain 0.0064 PF00042 Globin 0.0056 PF00102 Protein-tyrosine phosphatase 0.0053 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0053 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0044 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0037 PF00156 Phosphoribosyl transferase domain 0.0033 PF00464 Serine hydroxymethyltransferase 0.0027 PF08919 F-actin binding 0.0025 PF00858 Amiloride-sensitive sodium channel 0.0022 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0022 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0021 PF01268 Formate--tetrahydrofolate ligase 0.0017 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB658 C-N-C:C-C 0.1028 PF03073 TspO/MBR family 0.1024 PF00194 Eukaryotic-type carbonic anhydrase 0.0796 PF00186 Dihydrofolate reductase 0.0574 PF00069 Protein kinase domain 0.0442 PF01048 Phosphorylase superfamily 0.0418 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0414 PF00001 7 transmembrane receptor (rhodopsin family), 0.0397 PF08403 Amino acid permease N-terminal 0.0352 PF08070 DTHCT (NUC029), region 0.0352 PF00204 DNA gyrase B 0.0352 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0302 PF06512 Sodium ion transport-associated 0.0242 PF02254 TrkA-N domain 0.0242 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0205 PF00005 ABC transporter 0.0193 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0155 PF00478 IMP dehydrogenase / GMP reductase domain 0.0140 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0137 PF01126 Heme oxygenase 0.0119 PF00962 Adenosine/AMP deaminase 0.0108 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0108 PF01061 ABC-2 type transporter 0.0104 PF00017 SH2 domain 0.0099 PF00520 Ion transport protein 0.0094 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0094 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0091 PF00018 SH3 domain 0.0086 PF01590 GAF domain 0.0080 PF00664 ABC transporter transmembrane region 0.0067 PF00571 CBS domain 0.0064 PF00042 Globin 0.0056 PF00102 Protein-tyrosine phosphatase 0.0053 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0053 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0044 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0037 PF00156 Phosphoribosyl transferase domain 0.0033 PF00464 Serine hydroxymethyltransferase 0.0027 PF08919 F-actin binding 0.0025 PF00858 Amiloride-sensitive sodium channel 0.0022 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0022 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0021 PF01268 Formate--tetrahydrofolate ligase 0.0017 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB496 C-N-C:C 0.1028 PF03073 TspO/MBR family 0.1024 PF00194 Eukaryotic-type carbonic anhydrase 0.0796 PF00186 Dihydrofolate reductase 0.0574 PF00069 Protein kinase domain 0.0442 PF01048 Phosphorylase superfamily 0.0418 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0415 PF00001 7 transmembrane receptor (rhodopsin family), 0.0397 PF08403 Amino acid permease N-terminal 0.0352 PF00204 DNA gyrase B 0.0352 PF08070 DTHCT (NUC029), region 0.0352 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0303 PF06512 Sodium ion transport-associated 0.0242 PF02254 TrkA-N domain 0.0242 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0205 PF00005 ABC transporter 0.0193 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0155 PF00478 IMP dehydrogenase / GMP reductase domain 0.0140 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0137 PF01126 Heme oxygenase 0.0119 PF00962 Adenosine/AMP deaminase 0.0108 PF01061 ABC-2 type transporter 0.0108 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0104 PF00017 SH2 domain 0.0099 PF00520 Ion transport protein 0.0094 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0094 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0091 PF00018 SH3 domain 0.0086 PF01590 GAF domain 0.0080 PF00664 ABC transporter transmembrane region 0.0067 PF00571 CBS domain 0.0064 PF00042 Globin 0.0056 PF00102 Protein-tyrosine phosphatase 0.0053 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0053 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0044 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0037 PF00156 Phosphoribosyl transferase domain 0.0033 PF00464 Serine hydroxymethyltransferase 0.0027 PF08919 F-actin binding 0.0025 PF00858 Amiloride-sensitive sodium channel 0.0022 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0022 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0021 PF01268 Formate--tetrahydrofolate ligase 0.0017 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB486 N:C:C:N 0.1011 PF00227 Proteasome subunit 0.0149 PF01122 Eukaryotic cobalamin-binding protein 0.0140 PF01048 Phosphorylase superfamily 0.0121 PF00069 Protein kinase domain 0.0121 PF00478 IMP dehydrogenase / GMP reductase domain 0.0108 PF00186 Dihydrofolate reductase 0.0102 PF02310 B12 binding domain 0.0101 PF01642 Methylmalonyl-CoA mutase 0.0101 PF03308 ArgK protein 0.0101 PF01923 Cobalamin adenosyltransferase 0.0089 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0081 PF00571 CBS domain 0.0074 PF00962 Adenosine/AMP deaminase 0.0069 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0060 PF08240 Alcohol dehydrogenase GroES-like domain 0.0059 PF00156 Phosphoribosyl transferase domain 0.0058 PF00107 Zinc-binding dehydrogenase 0.0055 PF00106 short chain dehydrogenase 0.0049 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0048 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0048 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0045 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0045 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0045 PF01590 GAF domain 0.0045 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0043 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0042 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0042 PF02607 B12 binding domain 0.0042 PF00809 Pterin binding enzyme 0.0041 PF00431 CUB domain 0.0039 PF00667 FAD binding domain 0.0039 PF00258 Flavodoxin 0.0038 PF00175 Oxidoreductase NAD-binding domain 0.0037 PF00171 Aldehyde dehydrogenase family 0.0037 PF00858 Amiloride-sensitive sodium channel 0.0034 PF00017 SH2 domain 0.0033 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0033 PF01467 Cytidylyltransferase 0.0033 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0030 PF00018 SH3 domain 0.0029 PF02223 Thymidylate kinase 0.0027 PF01126 Heme oxygenase 0.0027 PF07645 Calcium-binding EGF domain 0.0024 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0024 PF00970 Oxidoreductase FAD-binding domain 0.0024 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0024 PF00501 AMP-binding enzyme 0.0023 PF01652 Eukaryotic initiation factor 4E 0.0022 PF02574 Homocysteine S-methyltransferase 0.0022 PF01575 MaoC like domain 0.0022 PF02036 SCP-2 sterol transfer family 0.0022 PF08919 F-actin binding 0.0020 PF08676 MutL C terminal dimerisation domain 0.0020 PF12473 Kinesin protein 0.0020 PF12423 Kinesin protein 1B 0.0020 PF00498 FHA domain 0.0020 PF01119 DNA mismatch repair protein, C-terminal domain 0.0020 PF01230 HIT domain 0.0019 PF00136 DNA polymerase family B 0.0019 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0019 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0019 PF03104 DNA polymerase family B, exonuclease domain 0.0019 PF10397 Adenylosuccinate lyase C-terminus 0.0019 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0019 PF02233 NAD(P), transhydrogenase beta subunit 0.0019 PF08996 DNA Polymerase alpha zinc finger 0.0019 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0018 PF00821 Phosphoenolpyruvate carboxykinase 0.0018 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0018 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0017 PF00931 NB-ARC domain 0.0017 PF00248 Aldo/keto reductase family 0.0017 PF00400 WD domain, G-beta repeat 0.0017 PF00225 Kinesin motor domain 0.0017 PF01808 AICARFT/IMPCHase bienzyme 0.0016 PF03949 Malic enzyme, NAD binding domain 0.0016 PF02525 Flavodoxin-like fold 0.0016 PF02267 ADP-ribosyl cyclase 0.0016 PF00676 Dehydrogenase E1 component 0.0016 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0016 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0016 PF07966 A1 Propeptide 0.0016 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0016 PF00390 Malic enzyme, N-terminal domain 0.0016 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0015 PF00689 Cation transporting ATPase, C-terminus 0.0015 PF00378 Enoyl-CoA hydratase/isomerase family 0.0015 PF03770 Inositol polyphosphate kinase 0.0015 PF00690 Cation transporter/ATPase, N-terminus 0.0014 PF00071 Ras family 0.0013 PF00702 haloacid dehalogenase-like hydrolase 0.0013 PF08515 Transforming growth factor beta type I GS-motif 0.0013 PF01064 Activin types I and II receptor domain 0.0012 PF00958 GMP synthase C terminal domain 0.0012 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0012 PF03477 ATP cone domain 0.0012 PF00317 Ribonucleotide reductase, all-alpha domain 0.0012 PF02867 Ribonucleotide reductase, barrel domain 0.0012 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0011 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0011 PF03073 TspO/MBR family 0.0010 PF00310 Glutamine amidotransferases class-II 0.0010 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0010 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0010 PF05347 Complex 1 protein (LYR family), 0.0009 PF01068 ATP dependent DNA ligase domain 0.0009 PF00334 Nucleoside diphosphate kinase 0.0009 PF00536 SAM domain (Sterile alpha motif), 0.0009 PF03024 Folate receptor family 0.0009 PF09027 GTPase binding 0.0009 PF00122 E1-E2 ATPase 0.0009 PF00025 ADP-ribosylation factor family 0.0009 PF04679 ATP dependent DNA ligase C terminal region 0.0009 PF11555 EGFR receptor inhibitor Mig-6 0.0009 PF01404 Ephrin receptor ligand binding domain 0.0009 PF01268 Formate--tetrahydrofolate ligase 0.0008 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0008 PF02779 Transketolase, pyrimidine binding domain 0.0008 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0007 PF01030 Receptor L domain 0.0007 PF01712 Deoxynucleoside kinase 0.0007 PF00042 Globin 0.0007 PF00757 Furin-like cysteine rich region 0.0007 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0007 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0006 PF08063 PADR1 (NUC008), domain 0.0006 PF00533 BRCA1 C Terminus (BRCT), domain 0.0006 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0006 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0006 PF01370 NAD dependent epimerase/dehydratase family 0.0006 PF01687 Riboflavin kinase 0.0006 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0006 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0006 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0006 PF00206 Lyase 0.0006 PF05406 WGR domain 0.0005 PF01916 Deoxyhypusine synthase 0.0005 PF00005 ABC transporter 0.0005 PF02888 Calmodulin binding domain 0.0005 PF03530 Calcium-activated SK potassium channel 0.0005 PF00792 Phosphoinositide 3-kinase C2 0.0005 PF00794 PI3-kinase family, ras-binding domain 0.0005 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0004 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0004 PF02772 S-adenosylmethionine synthetase, central domain 0.0004 PF00026 Eukaryotic aspartyl protease 0.0004 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0003 PF09326 Domain of unknown function (DUF1982), 0.0003 PF10509 Galactokinase galactose-binding signature 0.0003 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0003 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0003 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0003 PF00221 Phenylalanine and histidine ammonia-lyase 0.0003 PF04716 ETC complex I subunit conserved region 0.0003 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0003 PF00629 MAM domain 0.0003 PF01434 Peptidase family M41 0.0003 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0003 PF00439 Bromodomain 0.0003 PF01835 MG2 domain 0.0003 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0003 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0003 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0003 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0003 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0003 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0003 PF08040 MNLL subunit 0.0003 PF02817 e3 binding domain 0.0003 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0003 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0003 PF00384 Molybdopterin oxidoreductase 0.0003 PF07677 A-macroglobulin receptor 0.0003 PF07678 A-macroglobulin complement component 0.0003 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0003 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0003 PF00348 Polyprenyl synthetase 0.0003 PF01747 ATP-sulfurylase 0.0003 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0003 PF04800 ETC complex I subunit conserved region 0.0003 PF00300 Phosphoglycerate mutase family 0.0003 PF00012 Hsp70 protein 0.0003 PF10276 Zinc-finger domain 0.0003 PF09166 Biliverdin reductase, catalytic 0.0003 PF06212 GRIM-19 protein 0.0003 PF02493 MORN repeat 0.0003 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0003 PF10531 SLBB domain 0.0003 PF00288 GHMP kinases N terminal domain 0.0003 PF00287 Sodium / potassium ATPase beta chain 0.0003 PF00183 Hsp90 protein 0.0003 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0003 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0003 PF00899 ThiF family 0.0003 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0003 PF04116 Fatty acid hydroxylase superfamily 0.0003 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0003 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0003 PF02173 pKID domain 0.0003 PF02037 SAP domain 0.0003 PF00004 ATPase family associated with various cellular activities (AAA), 0.0003 PF01591 6-phosphofructo-2-kinase 0.0003 PF00316 Fructose-1-6-bisphosphatase 0.0003 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0003 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0003 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0003 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0003 PF00058 Low-density lipoprotein receptor repeat class B 0.0003 PF00057 Low-density lipoprotein receptor domain class A 0.0003 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0003 PF01583 Adenylylsulphate kinase 0.0003 PF00856 SET domain 0.0003 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0003 PF02466 Tim17/Tim22/Tim23 family 0.0003 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0003 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0003 PF08544 GHMP kinases C terminal 0.0003 PF12062 heparan sulfate-N-deacetylase 0.0003 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0003 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0002 PF02793 Hormone receptor domain 0.0002 PF00615 Regulator of G protein signaling domain 0.0002 PF00002 7 transmembrane receptor (Secretin family), 0.0002 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0002 PF00291 Pyridoxal-phosphate dependent enzyme 0.0002 PF01833 IPT/TIG domain 0.0002 PF01437 Plexin repeat 0.0002 PF01403 Sema domain 0.0001 PF00108 Thiolase, N-terminal domain 0.0001 PF01017 STAT protein, all-alpha domain 0.0001 PF03727 Hexokinase 0.0001 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0001 PF02196 Raf-like Ras-binding domain 0.0001 PF02803 Thiolase, C-terminal domain 0.0001 PF00343 Carbohydrate phosphorylase 0.0001 PF00349 Hexokinase 0.0001 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0001 PF02865 STAT protein, protein interaction domain 0.0001 PF02864 STAT protein, DNA binding domain 0.0001 PF00619 Caspase recruitment domain 0.0001 PF01582 TIR domain 0.0001 PF02142 MGS-like domain 0.0001 PF01061 ABC-2 type transporter SUB684 N-C-C-C-C-C 0.1010 PF00001 7 transmembrane receptor (rhodopsin family), 0.0403 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0333 PF00209 Sodium:neurotransmitter symporter family 0.0240 PF03073 TspO/MBR family 0.0197 PF01401 Angiotensin-converting enzyme 0.0143 PF00005 ABC transporter 0.0123 PF00664 ABC transporter transmembrane region 0.0117 PF00989 PAS fold 0.0103 PF00186 Dihydrofolate reductase 0.0099 PF00027 Cyclic nucleotide-binding domain 0.0097 PF02223 Thymidylate kinase 0.0083 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0080 PF01048 Phosphorylase superfamily 0.0068 PF00069 Protein kinase domain 0.0065 PF06512 Sodium ion transport-associated 0.0060 PF05649 Peptidase family M13 0.0060 PF01431 Peptidase family M13 0.0050 PF00520 Ion transport protein 0.0046 PF00017 SH2 domain 0.0045 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0045 PF02180 Bcl-2 homology region 4 0.0041 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0041 PF02267 ADP-ribosyl cyclase 0.0041 PF08983 Domain of unknown function (DUF1856), 0.0036 PF01007 Inward rectifier potassium channel 0.0026 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0024 PF01842 ACT domain 0.0023 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0023 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0022 PF00464 Serine hydroxymethyltransferase 0.0020 PF01061 ABC-2 type transporter 0.0019 PF00018 SH3 domain 0.0019 PF01467 Cytidylyltransferase 0.0018 PF00255 Glutathione peroxidase 0.0018 PF00303 Thymidylate synthase 0.0018 PF02798 Glutathione S-transferase, N-terminal domain 0.0016 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0016 PF01234 NNMT/PNMT/TEMT family 0.0016 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0016 PF08919 F-actin binding 0.0014 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0014 PF00043 Glutathione S-transferase, C-terminal domain 0.0014 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0011 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0010 PF01590 GAF domain 0.0009 PF00551 Formyl transferase 0.0009 PF03807 NADP oxidoreductase coenzyme F420-dependent 0.0008 PF08491 Squalene epoxidase 0.0006 PF00088 Trefoil (P-type), domain 0.0006 PF08441 Integrin alpha 0.0006 PF01055 Glycosyl hydrolases family 31 0.0005 PF09396 Thrombin light chain 0.0005 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0004 PF02173 pKID domain 0.0004 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0004 PF01808 AICARFT/IMPCHase bienzyme 0.0004 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0004 PF07966 A1 Propeptide 0.0004 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0004 PF08063 PADR1 (NUC008), domain 0.0004 PF00533 BRCA1 C Terminus (BRCT), domain 0.0004 PF01687 Riboflavin kinase 0.0004 PF05406 WGR domain 0.0003 PF08403 Amino acid permease N-terminal 0.0003 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0003 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0003 PF02008 CXXC zinc finger domain 0.0003 PF01426 BAH domain 0.0003 PF01571 Aminomethyltransferase folate-binding domain 0.0003 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0003 PF01122 Eukaryotic cobalamin-binding protein 0.0003 PF00026 Eukaryotic aspartyl protease 0.0003 PF00357 Integrin alpha cytoplasmic region 0.0003 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0003 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0003 PF06464 DMAP1-binding Domain 0.0001 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0001 PF08070 DTHCT (NUC029), region 0.0001 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0001 PF01268 Formate--tetrahydrofolate ligase 0.0001 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0001 PF00204 DNA gyrase B 0.0001 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0001 PF00755 Choline/Carnitine o-acyltransferase SUB717 Cc1ccc(N)cc1 0.1006 PF08070 DTHCT (NUC029), region 0.1006 PF00204 DNA gyrase B 0.1006 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0500 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0381 PF00102 Protein-tyrosine phosphatase 0.0255 PF01048 Phosphorylase superfamily 0.0246 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0164 PF00303 Thymidylate synthase 0.0148 PF01590 GAF domain 0.0140 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0126 PF02525 Flavodoxin-like fold 0.0120 PF00576 HIUase/Transthyretin family 0.0119 PF05406 WGR domain 0.0119 PF00533 BRCA1 C Terminus (BRCT), domain 0.0119 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0119 PF08063 PADR1 (NUC008), domain 0.0119 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0116 PF00821 Phosphoenolpyruvate carboxykinase 0.0113 PF01467 Cytidylyltransferase 0.0112 PF01268 Formate--tetrahydrofolate ligase 0.0106 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0106 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0101 PF01808 AICARFT/IMPCHase bienzyme 0.0096 PF00107 Zinc-binding dehydrogenase 0.0095 PF00106 short chain dehydrogenase 0.0093 PF08240 Alcohol dehydrogenase GroES-like domain 0.0087 PF00071 Ras family 0.0087 PF00248 Aldo/keto reductase family 0.0079 PF00858 Amiloride-sensitive sodium channel 0.0076 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0071 PF00186 Dihydrofolate reductase 0.0069 PF01652 Eukaryotic initiation factor 4E 0.0067 PF02223 Thymidylate kinase 0.0064 PF01370 NAD dependent epimerase/dehydratase family 0.0064 PF02142 MGS-like domain 0.0063 PF00183 Hsp90 protein 0.0058 PF03098 Animal haem peroxidase 0.0056 PF00227 Proteasome subunit 0.0054 PF03024 Folate receptor family 0.0050 PF00464 Serine hydroxymethyltransferase 0.0048 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0048 PF01571 Aminomethyltransferase folate-binding domain 0.0047 PF00551 Formyl transferase 0.0046 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0046 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0042 PF00171 Aldehyde dehydrogenase family 0.0041 PF02267 ADP-ribosyl cyclase 0.0040 PF01575 MaoC like domain 0.0040 PF02036 SCP-2 sterol transfer family 0.0040 PF00025 ADP-ribosylation factor family 0.0038 PF00493 MCM2/3/5 family 0.0034 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0034 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0034 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0033 PF01061 ABC-2 type transporter 0.0033 PF00305 Lipoxygenase 0.0033 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0033 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0031 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0031 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0028 PF02233 NAD(P), transhydrogenase beta subunit 0.0024 PF08919 F-actin binding 0.0024 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0023 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0022 PF02219 Methylenetetrahydrofolate reductase 0.0022 PF00822 PMP-22/EMP/MP20/Claudin family 0.0022 PF00018 SH3 domain 0.0020 PF01731 Arylesterase 0.0020 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0020 PF00017 SH2 domain 0.0020 PF00999 Sodium/hydrogen exchanger family 0.0020 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0020 PF01180 Dihydroorotate dehydrogenase 0.0019 PF02059 Interleukin-3 0.0018 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0018 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0017 PF03360 Glycosyltransferase family 43 0.0017 PF00028 Cadherin domain 0.0016 PF06448 Domain of Unknown Function (DUF1081), 0.0016 PF12491 Apolipoprotein B100 C terminal 0.0016 PF00571 CBS domain 0.0015 PF00550 Phosphopantetheine attachment site 0.0015 PF00478 IMP dehydrogenase / GMP reductase domain 0.0014 PF01023 S-100/ICaBP type calcium binding domain 0.0013 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0013 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0012 PF02911 Formyl transferase, C-terminal domain 0.0012 PF02769 AIR synthase related protein, C-terminal domain 0.0012 PF00586 AIR synthase related protein, N-terminal domain 0.0011 PF03949 Malic enzyme, NAD binding domain 0.0011 PF10420 Cytokine interleukin-12p40 C-terminus 0.0011 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0011 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0011 PF00390 Malic enzyme, N-terminal domain 0.0010 PF07722 Peptidase C26 0.0009 PF00377 Prion/Doppel alpha-helical domain 0.0008 PF01404 Ephrin receptor ligand binding domain 0.0008 PF00536 SAM domain (Sterile alpha motif), 0.0008 PF01347 Lipoprotein amino terminal region 0.0008 PF01227 GTP cyclohydrolase I 0.0007 PF00264 Common central domain of tyrosinase 0.0006 PF00656 Caspase domain 0.0006 PF00654 Voltage gated chloride channel 0.0006 PF00341 Platelet-derived growth factor (PDGF), 0.0006 PF00868 Transglutaminase family 0.0006 PF00927 Transglutaminase family, C-terminal ig like domain 0.0006 PF01841 Transglutaminase-like superfamily 0.0006 PF08403 Amino acid permease N-terminal 0.0005 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0005 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0003 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0002 PF01916 Deoxyhypusine synthase 0.0002 PF00676 Dehydrogenase E1 component 0.0002 PF02394 Interleukin-1 propeptide 0.0002 PF00340 Interleukin-1 / 18 0.0002 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0001 PF00385 chromo (CHRromatin Organisation MOdifier), domain SUB347 C(~C)(~H)(~O) 0.1002 PF00191 Annexin 0.0923 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0874 PF02806 Alpha amylase, C-terminal all-beta domain 0.0821 PF02155 Glucocorticoid receptor 0.0613 PF00128 Alpha amylase, catalytic domain 0.0595 PF03414 Glycosyltransferase family 6 0.0541 PF00079 Serpin (serine protease inhibitor), 0.0493 PF01048 Phosphorylase superfamily 0.0428 PF03953 Tubulin C-terminal domain 0.0428 PF00091 Tubulin/FtsZ family, GTPase domain 0.0376 PF02223 Thymidylate kinase 0.0309 PF01735 Lysophospholipase catalytic domain 0.0280 PF00303 Thymidylate synthase 0.0243 PF00106 short chain dehydrogenase 0.0200 PF00059 Lectin C-type domain 0.0196 PF00167 Fibroblast growth factor 0.0172 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0163 PF03770 Inositol polyphosphate kinase 0.0145 PF00005 ABC transporter 0.0139 PF00704 Glycosyl hydrolases family 18 0.0139 PF01607 Chitin binding Peritrophin-A domain 0.0126 PF01467 Cytidylyltransferase 0.0106 PF00084 Sushi domain (SCR repeat), 0.0105 PF00664 ABC transporter transmembrane region 0.0103 PF02267 ADP-ribosyl cyclase 0.0100 PF00171 Aldehyde dehydrogenase family 0.0097 PF00349 Hexokinase 0.0097 PF03727 Hexokinase 0.0094 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0094 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0091 PF07654 Immunoglobulin C1-set domain 0.0088 PF00976 Corticotropin ACTH domain 0.0088 PF08035 Opioids neuropeptide 0.0088 PF08384 Pro-opiomelanocortin, N-terminal region 0.0086 PF01370 NAD dependent epimerase/dehydratase family 0.0085 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.0072 PF01532 Glycosyl hydrolase family 47 0.0061 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0061 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0061 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0050 PF08240 Alcohol dehydrogenase GroES-like domain 0.0033 PF00248 Aldo/keto reductase family 0.0030 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0028 PF00107 Zinc-binding dehydrogenase 0.0027 PF00143 Interferon alpha/beta domain 0.0026 PF01687 Riboflavin kinase 0.0025 PF00071 Ras family 0.0018 PF01842 ACT domain 0.0017 PF01122 Eukaryotic cobalamin-binding protein 0.0017 PF01230 HIT domain 0.0014 PF00571 CBS domain 0.0010 PF03360 Glycosyltransferase family 43 0.0004 PF01055 Glycosyl hydrolases family 31 0.0004 PF00088 Trefoil (P-type), domain 0.0001 PF00229 TNF(Tumour Necrosis Factor), family SUB38 >= 1 Cl 0.0992 PF03073 TspO/MBR family 0.0944 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0944 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0399 PF00194 Eukaryotic-type carbonic anhydrase 0.0386 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0386 PF02254 TrkA-N domain 0.0288 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0287 PF08403 Amino acid permease N-terminal 0.0285 PF00146 NADH dehydrogenase 0.0183 PF00689 Cation transporting ATPase, C-terminus 0.0183 PF00690 Cation transporter/ATPase, N-terminus 0.0159 PF00122 E1-E2 ATPase 0.0150 PF00520 Ion transport protein 0.0142 PF02888 Calmodulin binding domain 0.0142 PF03530 Calcium-activated SK potassium channel 0.0136 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0134 PF01007 Inward rectifier potassium channel 0.0134 PF00702 haloacid dehalogenase-like hydrolase 0.0128 PF00631 GGL domain 0.0128 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0114 PF00191 Annexin 0.0109 PF00209 Sodium:neurotransmitter symporter family 0.0103 PF02214 K+ channel tetramerisation domain 0.0102 PF00001 7 transmembrane receptor (rhodopsin family), 0.0090 PF00324 Amino acid permease 0.0085 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0074 PF00018 SH3 domain 0.0069 PF00989 PAS fold 0.0069 PF00343 Carbohydrate phosphorylase 0.0064 PF00186 Dihydrofolate reductase 0.0060 PF00017 SH2 domain 0.0060 PF00273 Serum albumin family 0.0059 PF12497 Estrogen receptor beta 0.0058 PF02196 Raf-like Ras-binding domain 0.0057 PF07885 Ion channel 0.0051 PF00060 Ligand-gated ion channel 0.0051 PF00027 Cyclic nucleotide-binding domain 0.0051 PF06512 Sodium ion transport-associated 0.0048 PF00069 Protein kinase domain 0.0045 PF08919 F-actin binding 0.0044 PF02155 Glucocorticoid receptor 0.0043 PF00664 ABC transporter transmembrane region 0.0040 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0039 PF02159 Oestrogen receptor 0.0038 PF00005 ABC transporter 0.0037 PF01094 Receptor family ligand binding region 0.0036 PF00757 Furin-like cysteine rich region 0.0036 PF01030 Receptor L domain 0.0035 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0034 PF00243 Nerve growth factor family 0.0034 PF00612 IQ calmodulin-binding motif 0.0034 PF03098 Animal haem peroxidase 0.0030 PF00536 SAM domain (Sterile alpha motif), 0.0030 PF01404 Ephrin receptor ligand binding domain 0.0027 PF00305 Lipoxygenase 0.0026 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0026 PF08377 MAP2/Tau projection domain 0.0025 PF01477 PLAT/LH2 domain 0.0024 PF00079 Serpin (serine protease inhibitor), 0.0023 PF02008 CXXC zinc finger domain 0.0023 PF01426 BAH domain 0.0023 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0023 PF06464 DMAP1-binding Domain 0.0019 PF02038 ATP1G1/PLM/MAT8 family 0.0019 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0019 PF03630 Fumble 0.0019 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0019 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0019 PF01734 Patatin-like phospholipase 0.0019 PF02060 Slow voltage-gated potassium channel 0.0018 PF00067 Cytochrome P450 0.0018 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0017 PF02865 STAT protein, protein interaction domain 0.0017 PF02864 STAT protein, DNA binding domain 0.0017 PF01017 STAT protein, all-alpha domain 0.0016 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0015 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0012 PF00145 C-5 cytosine-specific DNA methylase 0.0011 PF08063 PADR1 (NUC008), domain 0.0011 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0011 PF01234 NNMT/PNMT/TEMT family 0.0011 PF00533 BRCA1 C Terminus (BRCT), domain 0.0011 PF05406 WGR domain 0.0011 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0011 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0009 PF00462 Glutaredoxin 0.0008 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0008 PF00576 HIUase/Transthyretin family 0.0008 PF00042 Globin 0.0006 PF01582 TIR domain 0.0006 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0006 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0006 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0006 PF00675 Insulinase (Peptidase family M16), 0.0006 PF05193 Peptidase M16 inactive domain 0.0005 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0005 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0005 PF02743 Cache domain 0.0005 PF08399 VWA N-terminal 0.0005 PF03520 KCNQ voltage-gated potassium channel 0.0005 PF00102 Protein-tyrosine phosphatase 0.0005 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0004 PF01735 Lysophospholipase catalytic domain 0.0004 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0003 PF00204 DNA gyrase B 0.0003 PF07686 Immunoglobulin V-set domain 0.0003 PF08070 DTHCT (NUC029), region 0.0003 PF02166 Androgen receptor 0.0003 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0003 PF00105 Zinc finger, C4 type (two domains), 0.0003 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0002 PF00976 Corticotropin ACTH domain 0.0002 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0002 PF08384 Pro-opiomelanocortin, N-terminal region 0.0002 PF08035 Opioids neuropeptide 0.0001 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0001 PF00303 Thymidylate synthase 0.0001 PF00858 Amiloride-sensitive sodium channel SUB764 Oc1c(N)cccc1 0.0988 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0988 PF08070 DTHCT (NUC029), region 0.0988 PF00204 DNA gyrase B 0.0426 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0145 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0145 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0123 PF00576 HIUase/Transthyretin family 0.0113 PF01735 Lysophospholipase catalytic domain 0.0112 PF00102 Protein-tyrosine phosphatase 0.0090 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0083 PF00989 PAS fold 0.0077 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0075 PF00191 Annexin 0.0073 PF00273 Serum albumin family 0.0071 PF02155 Glucocorticoid receptor 0.0067 PF00091 Tubulin/FtsZ family, GTPase domain 0.0067 PF03953 Tubulin C-terminal domain 0.0066 PF00027 Cyclic nucleotide-binding domain 0.0060 PF00689 Cation transporting ATPase, C-terminus 0.0060 PF00690 Cation transporter/ATPase, N-terminus 0.0059 PF00079 Serpin (serine protease inhibitor), 0.0058 PF00194 Eukaryotic-type carbonic anhydrase 0.0058 PF03073 TspO/MBR family 0.0052 PF00122 E1-E2 ATPase 0.0051 PF02166 Androgen receptor 0.0050 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0050 PF00520 Ion transport protein 0.0048 PF03098 Animal haem peroxidase 0.0047 PF00168 C2 domain 0.0047 PF01180 Dihydroorotate dehydrogenase 0.0046 PF00303 Thymidylate synthase 0.0045 PF00702 haloacid dehalogenase-like hydrolase 0.0044 PF00317 Ribonucleotide reductase, all-alpha domain 0.0044 PF02867 Ribonucleotide reductase, barrel domain 0.0044 PF03477 ATP cone domain 0.0043 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0040 PF09396 Thrombin light chain 0.0038 PF00146 NADH dehydrogenase 0.0037 PF00493 MCM2/3/5 family 0.0037 PF00005 ABC transporter 0.0037 PF00405 Transferrin 0.0035 PF01061 ABC-2 type transporter 0.0035 PF02214 K+ channel tetramerisation domain 0.0032 PF01030 Receptor L domain 0.0032 PF00757 Furin-like cysteine rich region 0.0029 PF03104 DNA polymerase family B, exonuclease domain 0.0029 PF08996 DNA Polymerase alpha zinc finger 0.0029 PF00136 DNA polymerase family B 0.0027 PF07884 Vitamin K epoxide reductase family 0.0027 PF00664 ABC transporter transmembrane region 0.0026 PF00248 Aldo/keto reductase family 0.0025 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0025 PF00754 F5/8 type C domain 0.0024 PF03062 MBOAT family 0.0023 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0023 PF08919 F-actin binding 0.0023 PF06448 Domain of Unknown Function (DUF1081), 0.0023 PF12491 Apolipoprotein B100 C terminal 0.0023 PF00229 TNF(Tumour Necrosis Factor), family 0.0023 PF00017 SH2 domain 0.0021 PF05406 WGR domain 0.0021 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0021 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0021 PF08063 PADR1 (NUC008), domain 0.0021 PF00533 BRCA1 C Terminus (BRCT), domain 0.0021 PF00654 Voltage gated chloride channel 0.0021 PF00028 Cadherin domain 0.0021 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0020 PF00018 SH3 domain 0.0019 PF01731 Arylesterase 0.0019 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0019 PF02460 Patched family 0.0018 PF01347 Lipoprotein amino terminal region 0.0018 PF00069 Protein kinase domain 0.0017 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0017 PF01187 Macrophage migration inhibitory factor (MIF), 0.0016 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0016 PF02180 Bcl-2 homology region 4 0.0016 PF00305 Lipoxygenase 0.0016 PF03957 Jun-like transcription factor 0.0016 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0015 PF00291 Pyridoxal-phosphate dependent enzyme 0.0015 PF00489 Interleukin-6/G-CSF/MGF family 0.0015 PF03171 2OG-Fe(II), oxygenase superfamily 0.0015 PF00656 Caspase domain 0.0014 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0014 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0013 PF00266 Aminotransferase class-V 0.0013 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0013 PF01477 PLAT/LH2 domain 0.0013 PF08771 Rapamycin binding domain 0.0013 PF02196 Raf-like Ras-binding domain 0.0013 PF03949 Malic enzyme, NAD binding domain 0.0013 PF00390 Malic enzyme, N-terminal domain 0.0013 PF02260 FATC domain 0.0013 PF02259 FAT domain 0.0013 PF00043 Glutathione S-transferase, C-terminal domain 0.0012 PF02394 Interleukin-1 propeptide 0.0012 PF02798 Glutathione S-transferase, N-terminal domain 0.0012 PF00340 Interleukin-1 / 18 0.0011 PF00341 Platelet-derived growth factor (PDGF), 0.0011 PF00071 Ras family 0.0011 PF00058 Low-density lipoprotein receptor repeat class B 0.0011 PF01023 S-100/ICaBP type calcium binding domain 0.0011 PF01391 Collagen triple helix repeat (20 copies), 0.0010 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0010 PF02803 Thiolase, C-terminal domain 0.0010 PF00271 Helicase conserved C-terminal domain 0.0010 PF08659 KR domain 0.0010 PF00698 Acyl transferase domain 0.0010 PF00108 Thiolase, N-terminal domain 0.0010 PF00975 Thioesterase domain 0.0010 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0010 PF00554 Rel homology domain (RHD), 0.0010 PF00040 Fibronectin type II domain 0.0010 PF00155 Aminotransferase class I and II 0.0009 PF02059 Interleukin-3 0.0009 PF00002 7 transmembrane receptor (Secretin family), 0.0009 PF00170 bZIP transcription factor 0.0009 PF00085 Thioredoxin 0.0009 PF02793 Hormone receptor domain 0.0009 PF00377 Prion/Doppel alpha-helical domain 0.0009 PF01202 Shikimate kinase 0.0009 PF01596 O-methyltransferase 0.0008 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0008 PF00176 SNF2 family N-terminal domain 0.0008 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0008 PF00755 Choline/Carnitine o-acyltransferase 0.0007 PF00094 von Willebrand factor type D domain 0.0007 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0007 PF03034 Phosphatidyl serine synthase 0.0007 PF02824 TGS domain 0.0007 PF02525 Flavodoxin-like fold 0.0007 PF00781 Diacylglycerol kinase catalytic domain 0.0007 PF01068 ATP dependent DNA ligase domain 0.0007 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0007 PF08742 C8 domain 0.0007 PF04679 ATP dependent DNA ligase C terminal region 0.0007 PF02025 Interleukin 5 0.0007 PF00609 Diacylglycerol kinase accessory domain 0.0007 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0006 PF01425 Amidase 0.0006 PF01429 Methyl-CpG binding domain 0.0006 PF00274 Fructose-bisphosphate aldolase class-I 0.0006 PF00860 Permease family 0.0006 PF00342 Phosphoglucose isomerase 0.0006 PF00057 Low-density lipoprotein receptor domain class A 0.0006 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0006 PF08429 PLU-1-like protein 0.0006 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0006 PF02375 jmjN domain 0.0006 PF02373 JmjC domain 0.0006 PF01388 ARID/BRIGHT DNA binding domain 0.0006 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0006 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0006 PF02928 C5HC2 zinc finger 0.0006 PF00183 Hsp90 protein 0.0006 PF00628 PHD-finger 0.0006 PF00464 Serine hydroxymethyltransferase 0.0006 PF01753 MYND finger 0.0005 PF02403 Seryl-tRNA synthetase N-terminal domain 0.0005 PF00186 Dihydrofolate reductase 0.0005 PF11404 Potassium voltage-gated channel 0.0005 PF00432 Prenyltransferase and squalene oxidase repeat 0.0005 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0005 PF00246 Zinc carboxypeptidase 0.0005 PF03351 DOMON domain 0.0005 PF01403 Sema domain 0.0005 PF01130 CD36 family 0.0005 PF07647 SAM domain (Sterile alpha motif), 0.0005 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0005 PF09193 Cholecystokinin A receptor, N-terminal 0.0005 PF00969 Class II histocompatibility antigen, beta domain 0.0005 PF02666 Phosphatidylserine decarboxylase 0.0005 PF00717 Peptidase S24-like 0.0005 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0005 PF03473 MOSC domain 0.0005 PF03476 MOSC N-terminal beta barrel domain 0.0005 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0005 PF00550 Phosphopantetheine attachment site 0.0005 PF00270 DEAD/DEAH box helicase 0.0005 PF01437 Plexin repeat 0.0005 PF01833 IPT/TIG domain 0.0005 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0005 PF00343 Carbohydrate phosphorylase 0.0005 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0004 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.0004 PF02898 Nitric oxide synthase, oxygenase domain 0.0004 PF00406 Adenylate kinase 0.0004 PF00042 Globin 0.0004 PF00294 pfkB family carbohydrate kinase 0.0004 PF01017 STAT protein, all-alpha domain 0.0004 PF03623 Focal adhesion targeting region 0.0004 PF02864 STAT protein, DNA binding domain 0.0004 PF02865 STAT protein, protein interaction domain 0.0004 PF00051 Kringle domain 0.0004 PF03360 Glycosyltransferase family 43 0.0003 PF02347 Glycine cleavage system P-protein 0.0003 PF00821 Phosphoenolpyruvate carboxykinase 0.0003 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0003 PF00020 TNFR/NGFR cysteine-rich region 0.0003 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 0.0003 PF01212 Beta-eliminating lyase 0.0003 PF08403 Amino acid permease N-terminal 0.0003 PF01168 Alanine racemase, N-terminal domain 0.0003 PF00019 Transforming growth factor beta like domain 0.0003 PF00373 FERM central domain 0.0003 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0003 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0003 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0003 PF00688 TGF-beta propeptide 0.0003 PF00151 Lipase 0.0003 PF07690 Major Facilitator Superfamily 0.0003 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0003 PF00714 Interferon gamma 0.0003 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0002 PF00787 PX domain 0.0002 PF00571 CBS domain 0.0002 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0002 PF01462 Leucine rich repeat N-terminal domain 0.0002 PF00619 Caspase recruitment domain 0.0002 PF00682 HMGL-like 0.0002 PF00202 Aminotransferase class-III 0.0001 PF08454 RyR and IP3R Homology associated 0.0001 PF02210 Laminin G domain 0.0001 PF01365 RIH domain 0.0001 PF00794 PI3-kinase family, ras-binding domain 0.0001 PF00792 Phosphoinositide 3-kinase C2 0.0001 PF00648 Calpain family cysteine protease 0.0001 PF08709 Inositol 1,4,5-trisphosphate/ryanodine receptor 0.0001 PF03024 Folate receptor family 0.0001 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0001 PF01067 Calpain large subunit, domain III 0.0001 PF02971 Formiminotransferase domain 0.0001 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0001 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0001 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0001 PF02815 MIR domain 0.0001 PF00354 Pentaxin family 0.0001 PF00024 PAN domain 0.0001 PF00025 ADP-ribosylation factor family 0.0001 PF07648 Kazal-type serine protease inhibitor domain 0.0001 PF02758 PAAD/DAPIN/Pyrin domain 0.0001 PF02026 RyR domain 0.0001 PF03129 Anticodon binding domain 0.0001 PF00227 Proteasome subunit 0.0001 PF00433 Protein kinase C terminal domain 0.0001 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0001 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0001 PF06459 Ryanodine Receptor TM 4-6 0.0001 PF01433 Peptidase family M1 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0001 PF00074 Pancreatic ribonuclease 0.0001 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0001 PF04756 OST3 / OST6 family 0.0001 PF00622 SPRY domain 0.0001 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0001 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0001 PF04961 Formiminotransferase-cyclodeaminase SUB20 >= 2 O 0.0986 PF03098 Animal haem peroxidase 0.0734 PF00273 Serum albumin family 0.0567 PF01401 Angiotensin-converting enzyme 0.0530 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0530 PF00204 DNA gyrase B 0.0530 PF08070 DTHCT (NUC029), region 0.0323 PF00105 Zinc finger, C4 type (two domains), 0.0321 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0272 PF00091 Tubulin/FtsZ family, GTPase domain 0.0272 PF03953 Tubulin C-terminal domain 0.0256 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0237 PF00576 HIUase/Transthyretin family 0.0235 PF00102 Protein-tyrosine phosphatase 0.0200 PF01063 Aminotransferase class IV 0.0178 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0167 PF05649 Peptidase family M13 0.0167 PF01431 Peptidase family M13 0.0145 PF11825 Protein of unknown function (DUF3345), 0.0125 PF00079 Serpin (serine protease inhibitor), 0.0112 PF00191 Annexin 0.0109 PF02798 Glutathione S-transferase, N-terminal domain 0.0105 PF00043 Glutathione S-transferase, C-terminal domain 0.0093 PF00155 Aminotransferase class I and II 0.0088 PF00202 Aminotransferase class-III 0.0073 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0073 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0060 PF00464 Serine hydroxymethyltransferase 0.0058 PF09396 Thrombin light chain 0.0044 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0036 PF00151 Lipase 0.0034 PF01268 Formate--tetrahydrofolate ligase 0.0032 PF00822 PMP-22/EMP/MP20/Claudin family 0.0032 PF00024 PAN domain 0.0031 PF00733 Asparagine synthase 0.0024 PF02155 Glucocorticoid receptor 0.0022 PF02574 Homocysteine S-methyltransferase 0.0021 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0021 PF00375 Sodium:dicarboxylate symporter family 0.0020 PF01126 Heme oxygenase 0.0019 PF01490 Transmembrane amino acid transporter protein 0.0017 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0017 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0017 PF00764 Arginosuccinate synthase 0.0017 PF00490 Delta-aminolevulinic acid dehydratase 0.0017 PF00039 Fibronectin type I domain 0.0013 PF00255 Glutathione peroxidase 0.0011 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0010 PF00458 WHEP-TRS domain 0.0008 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0008 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0008 PF07706 Aminotransferase ubiquitination site 0.0008 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0007 PF07648 Kazal-type serine protease inhibitor domain 0.0006 PF04960 Glutaminase 0.0002 PF00854 POT family SUB435 C(-C)(-H)(=C) 0.0984 PF00001 7 transmembrane receptor (rhodopsin family), 0.0452 PF02159 Oestrogen receptor 0.0420 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0418 PF00105 Zinc finger, C4 type (two domains), 0.0415 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0399 PF03098 Animal haem peroxidase 0.0279 PF00209 Sodium:neurotransmitter symporter family 0.0193 PF06512 Sodium ion transport-associated 0.0191 PF08070 DTHCT (NUC029), region 0.0191 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0191 PF00204 DNA gyrase B 0.0151 PF00520 Ion transport protein 0.0117 PF03073 TspO/MBR family 0.0116 PF00191 Annexin 0.0111 PF02161 Progesterone receptor 0.0096 PF00194 Eukaryotic-type carbonic anhydrase 0.0091 PF00989 PAS fold 0.0087 PF09396 Thrombin light chain 0.0085 PF02155 Glucocorticoid receptor 0.0073 PF00067 Cytochrome P450 0.0073 PF00027 Cyclic nucleotide-binding domain 0.0054 PF01593 Flavin containing amine oxidoreductase 0.0038 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0033 PF00186 Dihydrofolate reductase 0.0031 PF01735 Lysophospholipase catalytic domain 0.0028 PF12497 Estrogen receptor beta 0.0027 PF01007 Inward rectifier potassium channel 0.0026 PF00305 Lipoxygenase 0.0021 PF00005 ABC transporter 0.0020 PF08403 Amino acid permease N-terminal 0.0015 PF00102 Protein-tyrosine phosphatase 0.0015 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0014 PF00576 HIUase/Transthyretin family 0.0009 PF00273 Serum albumin family 0.0008 PF00664 ABC transporter transmembrane region 0.0003 PF03953 Tubulin C-terminal domain 0.0003 PF00091 Tubulin/FtsZ family, GTPase domain 0.0002 PF07884 Vitamin K epoxide reductase family SUB408 O(~C)(~P) 0.0977 PF02223 Thymidylate kinase 0.0775 PF00348 Polyprenyl synthetase 0.0529 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0521 PF08240 Alcohol dehydrogenase GroES-like domain 0.0469 PF03770 Inositol polyphosphate kinase 0.0448 PF00107 Zinc-binding dehydrogenase 0.0423 PF00106 short chain dehydrogenase 0.0411 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0394 PF02267 ADP-ribosyl cyclase 0.0382 PF00102 Protein-tyrosine phosphatase 0.0356 PF01122 Eukaryotic cobalamin-binding protein 0.0341 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0341 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0339 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0339 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0339 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0322 PF01370 NAD dependent epimerase/dehydratase family 0.0290 PF00248 Aldo/keto reductase family 0.0276 PF00171 Aldehyde dehydrogenase family 0.0263 PF02310 B12 binding domain 0.0262 PF01467 Cytidylyltransferase 0.0250 PF01642 Methylmalonyl-CoA mutase 0.0250 PF01923 Cobalamin adenosyltransferase 0.0250 PF03308 ArgK protein 0.0216 PF00478 IMP dehydrogenase / GMP reductase domain 0.0202 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0202 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0167 PF00155 Aminotransferase class I and II 0.0160 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0158 PF00266 Aminotransferase class-V 0.0154 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0136 PF00571 CBS domain 0.0126 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0119 PF02607 B12 binding domain 0.0119 PF00809 Pterin binding enzyme 0.0119 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0117 PF00464 Serine hydroxymethyltransferase 0.0116 PF00431 CUB domain 0.0109 PF00258 Flavodoxin 0.0109 PF00667 FAD binding domain 0.0107 PF00175 Oxidoreductase NAD-binding domain 0.0104 PF00291 Pyridoxal-phosphate dependent enzyme 0.0099 PF00202 Aminotransferase class-III 0.0096 PF00169 PH domain 0.0095 PF01063 Aminotransferase class IV 0.0092 PF00343 Carbohydrate phosphorylase 0.0079 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0078 PF08674 Acetylcholinesterase tetramerisation domain 0.0077 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0077 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0076 PF00225 Kinesin motor domain 0.0076 PF07645 Calcium-binding EGF domain 0.0074 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0074 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0066 PF00294 pfkB family carbohydrate kinase 0.0062 PF00970 Oxidoreductase FAD-binding domain 0.0062 PF03360 Glycosyltransferase family 43 0.0062 PF01652 Eukaryotic initiation factor 4E 0.0061 PF01575 MaoC like domain 0.0061 PF02574 Homocysteine S-methyltransferase 0.0061 PF03949 Malic enzyme, NAD binding domain 0.0061 PF00390 Malic enzyme, N-terminal domain 0.0061 PF02036 SCP-2 sterol transfer family 0.0061 PF00069 Protein kinase domain 0.0060 PF00498 FHA domain 0.0060 PF01119 DNA mismatch repair protein, C-terminal domain 0.0060 PF12473 Kinesin protein 0.0060 PF00501 AMP-binding enzyme 0.0060 PF12423 Kinesin protein 1B 0.0060 PF08676 MutL C terminal dimerisation domain 0.0054 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0054 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0053 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0053 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0052 PF00702 haloacid dehalogenase-like hydrolase 0.0047 PF02233 NAD(P), transhydrogenase beta subunit 0.0045 PF00931 NB-ARC domain 0.0045 PF00400 WD domain, G-beta repeat 0.0040 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0040 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0039 PF03473 MOSC domain 0.0039 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0039 PF03476 MOSC N-terminal beta barrel domain 0.0038 PF01168 Alanine racemase, N-terminal domain 0.0038 PF00018 SH3 domain 0.0038 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0038 PF01212 Beta-eliminating lyase 0.0038 PF02347 Glycine cleavage system P-protein 0.0038 PF01202 Shikimate kinase 0.0037 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0037 PF04961 Formiminotransferase-cyclodeaminase 0.0037 PF07706 Aminotransferase ubiquitination site 0.0037 PF02971 Formiminotransferase domain 0.0032 PF00071 Ras family 0.0028 PF01596 O-methyltransferase 0.0027 PF00074 Pancreatic ribonuclease 0.0025 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0022 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0022 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0022 PF01126 Heme oxygenase 0.0010 PF00340 Interleukin-1 / 18 0.0010 PF02394 Interleukin-1 propeptide 0.0009 PF01268 Formate--tetrahydrofolate ligase 0.0009 PF00342 Phosphoglucose isomerase 0.0009 PF00058 Low-density lipoprotein receptor repeat class B 0.0009 PF00057 Low-density lipoprotein receptor domain class A 0.0009 PF01687 Riboflavin kinase 0.0008 PF00017 SH2 domain 0.0008 PF00676 Dehydrogenase E1 component 0.0008 PF00690 Cation transporter/ATPase, N-terminus 0.0008 PF00186 Dihydrofolate reductase 0.0008 PF00689 Cation transporting ATPase, C-terminus 0.0008 PF02525 Flavodoxin-like fold 0.0008 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0007 PF03727 Hexokinase 0.0007 PF00349 Hexokinase 0.0006 PF05347 Complex 1 protein (LYR family), 0.0006 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0006 PF01588 Putative tRNA binding domain 0.0006 PF01230 HIT domain 0.0006 PF00378 Enoyl-CoA hydratase/isomerase family 0.0006 PF00576 HIUase/Transthyretin family 0.0006 PF00122 E1-E2 ATPase 0.0005 PF01437 Plexin repeat 0.0005 PF01403 Sema domain 0.0005 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0005 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0005 PF02779 Transketolase, pyrimidine binding domain 0.0005 PF01833 IPT/TIG domain 0.0005 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0005 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0005 PF01916 Deoxyhypusine synthase 0.0003 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0003 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0003 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0003 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0003 PF00792 Phosphoinositide 3-kinase C2 0.0003 PF00794 PI3-kinase family, ras-binding domain 0.0003 PF00204 DNA gyrase B 0.0003 PF08070 DTHCT (NUC029), region 0.0003 PF01808 AICARFT/IMPCHase bienzyme 0.0002 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0002 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0002 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0002 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0002 PF10531 SLBB domain 0.0002 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0002 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0002 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0002 PF09166 Biliverdin reductase, catalytic 0.0002 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0002 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0002 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0002 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0002 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0002 PF10276 Zinc-finger domain 0.0002 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0002 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0002 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0002 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0002 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0002 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0002 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0002 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0002 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0002 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0002 PF02466 Tim17/Tim22/Tim23 family 0.0002 PF04716 ETC complex I subunit conserved region 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0002 PF09326 Domain of unknown function (DUF1982), 0.0002 PF02817 e3 binding domain 0.0002 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0002 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0002 PF04116 Fatty acid hydroxylase superfamily 0.0002 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0002 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0002 PF06212 GRIM-19 protein 0.0002 PF04800 ETC complex I subunit conserved region 0.0002 PF00149 Calcineurin-like phosphoesterase 0.0002 PF08040 MNLL subunit 0.0002 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0002 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0002 PF00384 Molybdopterin oxidoreductase 0.0001 PF00406 Adenylate kinase 0.0001 PF02780 Transketolase, C-terminal domain 0.0001 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0001 PF08515 Transforming growth factor beta type I GS-motif 0.0001 PF00962 Adenosine/AMP deaminase 0.0001 PF01064 Activin types I and II receptor domain 0.0001 PF00170 bZIP transcription factor 0.0001 PF00042 Globin 0.0001 PF03435 Saccharopine dehydrogenase 0.0001 PF02173 pKID domain SUB668 C=C-C-O-[#1] 0.0968 PF08070 DTHCT (NUC029), region 0.0968 PF00204 DNA gyrase B 0.0968 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0779 PF02159 Oestrogen receptor 0.0473 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0411 PF00001 7 transmembrane receptor (rhodopsin family), 0.0337 PF00105 Zinc finger, C4 type (two domains), 0.0329 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0301 PF00102 Protein-tyrosine phosphatase 0.0223 PF00576 HIUase/Transthyretin family 0.0153 PF12497 Estrogen receptor beta 0.0123 PF08035 Opioids neuropeptide 0.0123 PF08384 Pro-opiomelanocortin, N-terminal region 0.0123 PF00976 Corticotropin ACTH domain 0.0118 PF00989 PAS fold 0.0113 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0111 PF01048 Phosphorylase superfamily 0.0107 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0105 PF00005 ABC transporter 0.0100 PF00664 ABC transporter transmembrane region 0.0096 PF00027 Cyclic nucleotide-binding domain 0.0077 PF11825 Protein of unknown function (DUF3345), 0.0071 PF00303 Thymidylate synthase 0.0064 PF00643 B-box zinc finger 0.0064 PF01590 GAF domain 0.0063 PF00305 Lipoxygenase 0.0061 PF01596 O-methyltransferase 0.0061 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0057 PF02525 Flavodoxin-like fold 0.0052 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0052 PF08063 PADR1 (NUC008), domain 0.0052 PF00533 BRCA1 C Terminus (BRCT), domain 0.0052 PF05406 WGR domain 0.0052 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0051 PF00183 Hsp90 protein 0.0050 PF00821 Phosphoenolpyruvate carboxykinase 0.0049 PF01467 Cytidylyltransferase 0.0049 PF01477 PLAT/LH2 domain 0.0048 PF01268 Formate--tetrahydrofolate ligase 0.0046 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0046 PF02394 Interleukin-1 propeptide 0.0046 PF00340 Interleukin-1 / 18 0.0046 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0044 PF03062 MBOAT family 0.0043 PF01808 AICARFT/IMPCHase bienzyme 0.0042 PF00107 Zinc-binding dehydrogenase 0.0041 PF00106 short chain dehydrogenase 0.0041 PF00071 Ras family 0.0040 PF08240 Alcohol dehydrogenase GroES-like domain 0.0038 PF00248 Aldo/keto reductase family 0.0035 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0034 PF08983 Domain of unknown function (DUF1856), 0.0034 PF00858 Amiloride-sensitive sodium channel 0.0033 PF03098 Animal haem peroxidase 0.0032 PF00186 Dihydrofolate reductase 0.0030 PF01652 Eukaryotic initiation factor 4E 0.0029 PF00091 Tubulin/FtsZ family, GTPase domain 0.0029 PF02223 Thymidylate kinase 0.0029 PF03953 Tubulin C-terminal domain 0.0029 PF00656 Caspase domain 0.0028 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0028 PF02142 MGS-like domain 0.0027 PF01061 ABC-2 type transporter 0.0027 PF00273 Serum albumin family 0.0027 PF01180 Dihydroorotate dehydrogenase 0.0027 PF01370 NAD dependent epimerase/dehydratase family 0.0025 PF00227 Proteasome subunit 0.0024 PF03024 Folate receptor family 0.0024 PF00464 Serine hydroxymethyltransferase 0.0024 PF04622 ERG2 and Sigma1 receptor like protein 0.0023 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0022 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0022 PF09396 Thrombin light chain 0.0022 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0021 PF01160 Vertebrate endogenous opioids neuropeptide 0.0021 PF00918 Gastrin/cholecystokinin family 0.0021 PF00493 MCM2/3/5 family 0.0021 PF01571 Aminomethyltransferase folate-binding domain 0.0021 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0020 PF00551 Formyl transferase 0.0020 PF00377 Prion/Doppel alpha-helical domain 0.0019 PF08919 F-actin binding 0.0018 PF00171 Aldehyde dehydrogenase family 0.0018 PF02267 ADP-ribosyl cyclase 0.0017 PF00025 ADP-ribosylation factor family 0.0017 PF02036 SCP-2 sterol transfer family 0.0017 PF01575 MaoC like domain 0.0017 PF00018 SH3 domain 0.0017 PF00017 SH2 domain 0.0017 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0016 PF02180 Bcl-2 homology region 4 0.0016 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0016 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0015 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0015 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0015 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0015 PF01588 Putative tRNA binding domain 0.0014 PF00135 Carboxylesterase 0.0014 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0014 PF00405 Transferrin 0.0014 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0013 PF03765 CRAL/TRIO, N-terminus 0.0013 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0013 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0013 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0013 PF00650 CRAL/TRIO domain 0.0013 PF00341 Platelet-derived growth factor (PDGF), 0.0013 PF02460 Patched family 0.0013 PF08377 MAP2/Tau projection domain 0.0012 PF06327 Domain of Unknown Function (DUF1053), 0.0012 PF00884 Sulfatase 0.0012 PF02233 NAD(P), transhydrogenase beta subunit 0.0012 PF08441 Integrin alpha 0.0011 PF02059 Interleukin-3 0.0011 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0011 PF00229 TNF(Tumour Necrosis Factor), family 0.0011 PF00625 Guanylate kinase 0.0011 PF01731 Arylesterase 0.0010 PF12491 Apolipoprotein B100 C terminal 0.0010 PF00390 Malic enzyme, N-terminal domain 0.0010 PF02219 Methylenetetrahydrofolate reductase 0.0010 PF03949 Malic enzyme, NAD binding domain 0.0010 PF01023 S-100/ICaBP type calcium binding domain 0.0010 PF07884 Vitamin K epoxide reductase family 0.0010 PF01347 Lipoprotein amino terminal region 0.0010 PF06448 Domain of Unknown Function (DUF1081), 0.0010 PF00357 Integrin alpha cytoplasmic region 0.0010 PF00822 PMP-22/EMP/MP20/Claudin family 0.0009 PF02793 Hormone receptor domain 0.0009 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0009 PF00754 F5/8 type C domain 0.0009 PF00002 7 transmembrane receptor (Secretin family), 0.0009 PF03360 Glycosyltransferase family 43 0.0009 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0008 PF00170 bZIP transcription factor 0.0008 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0008 PF01735 Lysophospholipase catalytic domain 0.0008 PF07885 Ion channel 0.0008 PF00999 Sodium/hydrogen exchanger family 0.0008 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0008 PF00028 Cadherin domain 0.0008 PF00550 Phosphopantetheine attachment site 0.0008 PF00266 Aminotransferase class-V 0.0007 PF00478 IMP dehydrogenase / GMP reductase domain 0.0007 PF09193 Cholecystokinin A receptor, N-terminal 0.0007 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0007 PF02025 Interleukin 5 0.0007 PF08742 C8 domain 0.0007 PF00571 CBS domain 0.0007 PF00094 von Willebrand factor type D domain 0.0006 PF00291 Pyridoxal-phosphate dependent enzyme 0.0006 PF01187 Macrophage migration inhibitory factor (MIF), 0.0006 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0006 PF00079 Serpin (serine protease inhibitor), 0.0006 PF03171 2OG-Fe(II), oxygenase superfamily 0.0006 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0006 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0006 PF03957 Jun-like transcription factor 0.0005 PF02260 FATC domain 0.0005 PF02911 Formyl transferase, C-terminal domain 0.0005 PF02155 Glucocorticoid receptor 0.0005 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0005 PF00641 Zn-finger in Ran binding protein and others 0.0005 PF02798 Glutathione S-transferase, N-terminal domain 0.0005 PF00043 Glutathione S-transferase, C-terminal domain 0.0005 PF00586 AIR synthase related protein, N-terminal domain 0.0005 PF02769 AIR synthase related protein, C-terminal domain 0.0005 PF02201 SWIB/MDM2 domain 0.0005 PF08771 Rapamycin binding domain 0.0005 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0005 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0005 PF10420 Cytokine interleukin-12p40 C-terminus 0.0005 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0005 PF08763 Voltage gated calcium channel IQ domain 0.0005 PF02259 FAT domain 0.0005 PF00168 C2 domain 0.0004 PF00757 Furin-like cysteine rich region 0.0004 PF08659 KR domain 0.0004 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0004 PF02803 Thiolase, C-terminal domain 0.0004 PF00040 Fibronectin type II domain 0.0004 PF00155 Aminotransferase class I and II 0.0004 PF00654 Voltage gated chloride channel 0.0004 PF00068 Phospholipase A2 0.0004 PF01227 GTP cyclohydrolase I 0.0004 PF01030 Receptor L domain 0.0004 PF00536 SAM domain (Sterile alpha motif), 0.0004 PF01404 Ephrin receptor ligand binding domain 0.0004 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0004 PF00108 Thiolase, N-terminal domain 0.0004 PF00975 Thioesterase domain 0.0004 PF00698 Acyl transferase domain 0.0004 PF00271 Helicase conserved C-terminal domain 0.0004 PF07722 Peptidase C26 0.0003 PF00609 Diacylglycerol kinase accessory domain 0.0003 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0003 PF00058 Low-density lipoprotein receptor repeat class B 0.0003 PF01068 ATP dependent DNA ligase domain 0.0003 PF00620 RhoGAP domain 0.0003 PF01391 Collagen triple helix repeat (20 copies), 0.0003 PF04679 ATP dependent DNA ligase C terminal region 0.0003 PF00085 Thioredoxin 0.0003 PF00264 Common central domain of tyrosinase 0.0003 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0003 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0003 PF01202 Shikimate kinase 0.0003 PF01733 Nucleoside transporter 0.0003 PF02173 pKID domain 0.0003 PF00176 SNF2 family N-terminal domain 0.0003 PF00781 Diacylglycerol kinase catalytic domain 0.0003 PF08403 Amino acid permease N-terminal 0.0003 PF00191 Annexin 0.0003 PF00151 Lipase 0.0003 PF00755 Choline/Carnitine o-acyltransferase 0.0002 PF00927 Transglutaminase family, C-terminal ig like domain 0.0002 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0002 PF03351 DOMON domain 0.0002 PF11404 Potassium voltage-gated channel 0.0002 PF00717 Peptidase S24-like 0.0002 PF07647 SAM domain (Sterile alpha motif), 0.0002 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0002 PF03473 MOSC domain 0.0002 PF03476 MOSC N-terminal beta barrel domain 0.0002 PF03034 Phosphatidyl serine synthase 0.0002 PF03623 Focal adhesion targeting region 0.0002 PF00343 Carbohydrate phosphorylase 0.0002 PF00342 Phosphoglucose isomerase 0.0002 PF02928 C5HC2 zinc finger 0.0002 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0002 PF02403 Seryl-tRNA synthetase N-terminal domain 0.0002 PF01388 ARID/BRIGHT DNA binding domain 0.0002 PF00969 Class II histocompatibility antigen, beta domain 0.0002 PF00246 Zinc carboxypeptidase 0.0002 PF01841 Transglutaminase-like superfamily 0.0002 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0002 PF00051 Kringle domain 0.0002 PF01833 IPT/TIG domain 0.0002 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0002 PF00057 Low-density lipoprotein receptor domain class A 0.0002 PF08429 PLU-1-like protein 0.0002 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0002 PF01437 Plexin repeat 0.0002 PF01753 MYND finger 0.0002 PF00554 Rel homology domain (RHD), 0.0002 PF01403 Sema domain 0.0002 PF02824 TGS domain 0.0002 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0002 PF01130 CD36 family 0.0002 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0002 PF00628 PHD-finger 0.0002 PF00270 DEAD/DEAH box helicase 0.0002 PF01429 Methyl-CpG binding domain 0.0002 PF01425 Amidase 0.0002 PF00274 Fructose-bisphosphate aldolase class-I 0.0002 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0002 PF02666 Phosphatidylserine decarboxylase 0.0002 PF02373 JmjC domain 0.0002 PF00868 Transglutaminase family 0.0002 PF02375 jmjN domain 0.0002 PF00860 Permease family 0.0001 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0001 PF00489 Interleukin-6/G-CSF/MGF family 0.0001 PF02971 Formiminotransferase domain 0.0001 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0001 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.0001 PF07690 Major Facilitator Superfamily 0.0001 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0001 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0001 PF00202 Aminotransferase class-III 0.0001 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 0.0001 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0001 PF01462 Leucine rich repeat N-terminal domain 0.0001 PF03129 Anticodon binding domain 0.0001 PF00020 TNFR/NGFR cysteine-rich region 0.0001 PF00432 Prenyltransferase and squalene oxidase repeat 0.0001 PF01168 Alanine racemase, N-terminal domain 0.0001 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0001 PF02898 Nitric oxide synthase, oxygenase domain 0.0001 PF00019 Transforming growth factor beta like domain 0.0001 PF01916 Deoxyhypusine synthase 0.0001 PF01212 Beta-eliminating lyase 0.0001 PF00676 Dehydrogenase E1 component 0.0001 PF00787 PX domain 0.0001 PF00619 Caspase recruitment domain 0.0001 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0001 PF00294 pfkB family carbohydrate kinase 0.0001 PF00373 FERM central domain 0.0001 PF00714 Interferon gamma 0.0001 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0001 PF02347 Glycine cleavage system P-protein 0.0001 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0001 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0001 PF00688 TGF-beta propeptide 0.0001 PF00682 HMGL-like 0.0001 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0001 PF04961 Formiminotransferase-cyclodeaminase SUB619 C:C-C-C:C 0.0957 PF00001 7 transmembrane receptor (rhodopsin family), 0.0439 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0320 PF00209 Sodium:neurotransmitter symporter family 0.0291 PF03098 Animal haem peroxidase 0.0265 PF00194 Eukaryotic-type carbonic anhydrase 0.0232 PF00204 DNA gyrase B 0.0232 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0232 PF08070 DTHCT (NUC029), region 0.0215 PF06512 Sodium ion transport-associated 0.0193 PF00520 Ion transport protein 0.0182 PF03073 TspO/MBR family 0.0113 PF00989 PAS fold 0.0094 PF00027 Cyclic nucleotide-binding domain 0.0093 PF09396 Thrombin light chain 0.0083 PF00102 Protein-tyrosine phosphatase 0.0081 PF00186 Dihydrofolate reductase 0.0073 PF01593 Flavin containing amine oxidoreductase 0.0070 PF00576 HIUase/Transthyretin family 0.0064 PF08403 Amino acid permease N-terminal 0.0058 PF01007 Inward rectifier potassium channel 0.0049 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0044 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0040 PF00005 ABC transporter 0.0031 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0031 PF02254 TrkA-N domain 0.0026 PF01431 Peptidase family M13 0.0026 PF05649 Peptidase family M13 0.0026 PF07884 Vitamin K epoxide reductase family 0.0025 PF01401 Angiotensin-converting enzyme 0.0023 PF00017 SH2 domain 0.0022 PF00664 ABC transporter transmembrane region 0.0017 PF02159 Oestrogen receptor 0.0016 PF00069 Protein kinase domain 0.0014 PF00822 PMP-22/EMP/MP20/Claudin family 0.0014 PF12497 Estrogen receptor beta 0.0012 PF00018 SH3 domain 0.0011 PF08983 Domain of unknown function (DUF1856), 0.0011 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0009 PF00042 Globin 0.0003 PF00067 Cytochrome P450 0.0001 PF00089 Trypsin SUB646 O=C-N-C-C 0.0955 PF01401 Angiotensin-converting enzyme 0.0607 PF03073 TspO/MBR family 0.0595 PF09396 Thrombin light chain 0.0504 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0402 PF01471 Putative peptidoglycan binding domain 0.0402 PF00045 Hemopexin 0.0380 PF00102 Protein-tyrosine phosphatase 0.0366 PF02798 Glutathione S-transferase, N-terminal domain 0.0356 PF00043 Glutathione S-transferase, C-terminal domain 0.0354 PF00413 Matrixin 0.0280 PF01431 Peptidase family M13 0.0280 PF05649 Peptidase family M13 0.0227 PF08983 Domain of unknown function (DUF1856), 0.0226 PF01048 Phosphorylase superfamily 0.0222 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0169 PF01590 GAF domain 0.0161 PF00303 Thymidylate synthase 0.0127 PF00255 Glutathione peroxidase 0.0102 PF00051 Kringle domain 0.0089 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0086 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0084 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0084 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0083 PF06512 Sodium ion transport-associated 0.0076 PF01268 Formate--tetrahydrofolate ligase 0.0072 PF00854 POT family 0.0064 PF00551 Formyl transferase 0.0050 PF01808 AICARFT/IMPCHase bienzyme 0.0031 PF00868 Transglutaminase family 0.0031 PF00927 Transglutaminase family, C-terminal ig like domain 0.0031 PF01841 Transglutaminase-like superfamily 0.0028 PF00026 Eukaryotic aspartyl protease 0.0027 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0027 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0027 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0026 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0022 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0022 PF01571 Aminomethyltransferase folate-binding domain 0.0021 PF07966 A1 Propeptide 0.0011 PF00089 Trypsin 0.0006 PF00586 AIR synthase related protein, N-terminal domain 0.0006 PF02769 AIR synthase related protein, C-terminal domain 0.0001 PF02142 MGS-like domain SUB465 N-C-C=C 0.0953 PF03073 TspO/MBR family 0.0950 PF00194 Eukaryotic-type carbonic anhydrase 0.0739 PF00186 Dihydrofolate reductase 0.0533 PF00069 Protein kinase domain 0.0410 PF01048 Phosphorylase superfamily 0.0388 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0384 PF00001 7 transmembrane receptor (rhodopsin family), 0.0368 PF08403 Amino acid permease N-terminal 0.0327 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0327 PF00204 DNA gyrase B 0.0327 PF08070 DTHCT (NUC029), region 0.0281 PF06512 Sodium ion transport-associated 0.0224 PF02254 TrkA-N domain 0.0224 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0190 PF00005 ABC transporter 0.0179 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0144 PF00478 IMP dehydrogenase / GMP reductase domain 0.0130 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0127 PF01126 Heme oxygenase 0.0110 PF00962 Adenosine/AMP deaminase 0.0101 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0100 PF01061 ABC-2 type transporter 0.0097 PF00017 SH2 domain 0.0092 PF00520 Ion transport protein 0.0087 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0087 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0085 PF00018 SH3 domain 0.0080 PF01590 GAF domain 0.0074 PF00664 ABC transporter transmembrane region 0.0062 PF00571 CBS domain 0.0060 PF00042 Globin 0.0052 PF00102 Protein-tyrosine phosphatase 0.0049 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0049 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0041 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0034 PF00156 Phosphoribosyl transferase domain 0.0031 PF00464 Serine hydroxymethyltransferase 0.0025 PF08919 F-actin binding 0.0023 PF00858 Amiloride-sensitive sodium channel 0.0021 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0021 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0020 PF01268 Formate--tetrahydrofolate ligase 0.0015 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB21 >= 4 O 0.0919 PF02798 Glutathione S-transferase, N-terminal domain 0.0899 PF00043 Glutathione S-transferase, C-terminal domain 0.0544 PF00255 Glutathione peroxidase 0.0438 PF01431 Peptidase family M13 0.0438 PF05649 Peptidase family M13 0.0382 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0366 PF09396 Thrombin light chain 0.0308 PF01124 MAPEG family 0.0298 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0274 PF03953 Tubulin C-terminal domain 0.0274 PF00091 Tubulin/FtsZ family, GTPase domain 0.0264 PF01401 Angiotensin-converting enzyme 0.0241 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0241 PF03199 Eukaryotic glutathione synthase 0.0206 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0206 PF08702 Fibrinogen alpha/beta chain family 0.0189 PF01323 DSBA-like thioredoxin domain 0.0188 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0165 PF00656 Caspase domain 0.0164 PF08983 Domain of unknown function (DUF1856), 0.0154 PF00303 Thymidylate synthase 0.0145 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0139 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0133 PF00462 Glutaredoxin 0.0130 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0129 PF00273 Serum albumin family 0.0126 PF07722 Peptidase C26 0.0118 PF12160 Fibrinogen alpha C domain 0.0110 PF01406 tRNA synthetases class I (C), catalytic domain 0.0106 PF05995 Cysteine dioxygenase type I 0.0105 PF01019 Gamma-glutamyltranspeptidase 0.0105 PF00756 Putative esterase 0.0094 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0094 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0090 PF00619 Caspase recruitment domain 0.0089 PF00167 Fibroblast growth factor 0.0087 PF03074 Glutamate-cysteine ligase 0.0079 PF01459 Eukaryotic porin 0.0069 PF00079 Serpin (serine protease inhibitor), 0.0064 PF00439 Bromodomain 0.0064 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0059 PF00051 Kringle domain 0.0057 PF06617 M-phase inducer phosphatase 0.0057 PF00581 Rhodanese-like domain 0.0057 PF00089 Trypsin 0.0048 PF03002 Somatostatin/Cortistatin family 0.0047 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0046 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0041 PF00085 Thioredoxin 0.0040 PF00806 Pumilio-family RNA binding repeat 0.0040 PF00778 DIX domain 0.0040 PF08833 Axin beta-catenin binding domain 0.0039 PF00822 PMP-22/EMP/MP20/Claudin family 0.0035 PF00265 Thymidine kinase 0.0035 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0035 PF02146 Sir2 family 0.0034 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0034 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0030 PF02793 Hormone receptor domain 0.0030 PF00002 7 transmembrane receptor (Secretin family), 0.0029 PF00400 WD domain, G-beta repeat 0.0029 PF00024 PAN domain 0.0029 PF00342 Phosphoglucose isomerase 0.0029 PF00931 NB-ARC domain 0.0028 PF00405 Transferrin 0.0018 PF00854 POT family 0.0016 PF01268 Formate--tetrahydrofolate ligase 0.0015 PF02806 Alpha amylase, C-terminal all-beta domain 0.0015 PF00689 Cation transporting ATPase, C-terminus 0.0015 PF00690 Cation transporter/ATPase, N-terminus 0.0014 PF00059 Lectin C-type domain 0.0013 PF00122 E1-E2 ATPase 0.0012 PF00128 Alpha amylase, catalytic domain 0.0010 PF00702 haloacid dehalogenase-like hydrolase 0.0009 PF00586 AIR synthase related protein, N-terminal domain 0.0009 PF02769 AIR synthase related protein, C-terminal domain 0.0009 PF00084 Sushi domain (SCR repeat), 0.0009 PF10420 Cytokine interleukin-12p40 C-terminus 0.0009 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0008 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0008 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0008 PF00088 Trefoil (P-type), domain 0.0008 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0008 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0008 PF01055 Glycosyl hydrolases family 31 0.0008 PF09193 Cholecystokinin A receptor, N-terminal 0.0007 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0007 PF04679 ATP dependent DNA ligase C terminal region 0.0007 PF01068 ATP dependent DNA ligase domain 0.0007 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0006 PF00188 Cysteine-rich secretory protein family 0.0006 PF00108 Thiolase, N-terminal domain 0.0006 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0006 PF02803 Thiolase, C-terminal domain 0.0006 PF01731 Arylesterase 0.0006 PF01370 NAD dependent epimerase/dehydratase family 0.0006 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0006 PF00578 AhpC/TSA family 0.0005 PF01471 Putative peptidoglycan binding domain 0.0005 PF08771 Rapamycin binding domain 0.0005 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0005 PF00045 Hemopexin 0.0005 PF02460 Patched family 0.0005 PF02259 FAT domain 0.0005 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0005 PF02180 Bcl-2 homology region 4 0.0005 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0005 PF02260 FATC domain 0.0005 PF03414 Glycosyltransferase family 6 0.0004 PF03062 MBOAT family 0.0004 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0004 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0004 PF01835 MG2 domain 0.0004 PF07677 A-macroglobulin receptor 0.0004 PF07678 A-macroglobulin complement component 0.0004 PF03489 Saposin-like type B, region 2 0.0003 PF01652 Eukaryotic initiation factor 4E 0.0003 PF03073 TspO/MBR family 0.0003 PF03770 Inositol polyphosphate kinase 0.0003 PF02233 NAD(P), transhydrogenase beta subunit 0.0003 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0003 PF00169 PH domain 0.0002 PF00378 Enoyl-CoA hydratase/isomerase family 0.0002 PF00431 CUB domain 0.0002 PF00106 short chain dehydrogenase 0.0002 PF00248 Aldo/keto reductase family 0.0002 PF00151 Lipase 0.0002 PF00675 Insulinase (Peptidase family M16), 0.0002 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0002 PF02267 ADP-ribosyl cyclase 0.0002 PF05193 Peptidase M16 inactive domain 0.0001 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF00171 Aldehyde dehydrogenase family 0.0001 PF00779 BTK motif 0.0001 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0001 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0001 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0001 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0001 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0001 PF01433 Peptidase family M1 0.0001 PF00551 Formyl transferase 0.0001 PF03360 Glycosyltransferase family 43 0.0001 PF01122 Eukaryotic cobalamin-binding protein 0.0001 PF02223 Thymidylate kinase 0.0001 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0001 PF00406 Adenylate kinase 0.0001 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0001 PF07645 Calcium-binding EGF domain SUB421 C=O 0.0917 PF03098 Animal haem peroxidase 0.0693 PF00273 Serum albumin family 0.0539 PF08070 DTHCT (NUC029), region 0.0539 PF00204 DNA gyrase B 0.0539 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0510 PF01401 Angiotensin-converting enzyme 0.0337 PF00105 Zinc finger, C4 type (two domains), 0.0334 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0294 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0257 PF00576 HIUase/Transthyretin family 0.0245 PF00102 Protein-tyrosine phosphatase 0.0241 PF00091 Tubulin/FtsZ family, GTPase domain 0.0241 PF03953 Tubulin C-terminal domain 0.0198 PF01063 Aminotransferase class IV 0.0196 PF00191 Annexin 0.0193 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0154 PF00079 Serpin (serine protease inhibitor), 0.0133 PF01431 Peptidase family M13 0.0133 PF05649 Peptidase family M13 0.0127 PF02155 Glucocorticoid receptor 0.0108 PF11825 Protein of unknown function (DUF3345), 0.0106 PF00155 Aminotransferase class I and II 0.0088 PF00202 Aminotransferase class-III 0.0082 PF02798 Glutathione S-transferase, N-terminal domain 0.0079 PF00043 Glutathione S-transferase, C-terminal domain 0.0057 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0057 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0055 PF00464 Serine hydroxymethyltransferase 0.0050 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0043 PF09396 Thrombin light chain 0.0040 PF02159 Oestrogen receptor 0.0037 PF01268 Formate--tetrahydrofolate ligase 0.0033 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0027 PF00151 Lipase 0.0026 PF01842 ACT domain 0.0026 PF00733 Asparagine synthase 0.0024 PF00822 PMP-22/EMP/MP20/Claudin family 0.0024 PF00024 PAN domain 0.0023 PF01126 Heme oxygenase 0.0023 PF00557 Metallopeptidase family M24 0.0022 PF00303 Thymidylate synthase 0.0022 PF02806 Alpha amylase, C-terminal all-beta domain 0.0021 PF01735 Lysophospholipase catalytic domain 0.0019 PF02166 Androgen receptor 0.0016 PF02574 Homocysteine S-methyltransferase 0.0016 PF00375 Sodium:dicarboxylate symporter family 0.0015 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0015 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0014 PF01490 Transmembrane amino acid transporter protein 0.0013 PF00128 Alpha amylase, catalytic domain 0.0012 PF00764 Arginosuccinate synthase 0.0012 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0012 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0012 PF00490 Delta-aminolevulinic acid dehydratase 0.0012 PF00039 Fibronectin type I domain 0.0010 PF00255 Glutathione peroxidase 0.0008 PF07706 Aminotransferase ubiquitination site 0.0008 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0008 PF00458 WHEP-TRS domain 0.0007 PF03414 Glycosyltransferase family 6 0.0006 PF07648 Kazal-type serine protease inhibitor domain 0.0006 PF00248 Aldo/keto reductase family 0.0006 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0004 PF00291 Pyridoxal-phosphate dependent enzyme 0.0004 PF00175 Oxidoreductase NAD-binding domain 0.0004 PF04960 Glutaminase 0.0003 PF02898 Nitric oxide synthase, oxygenase domain 0.0002 PF03171 2OG-Fe(II), oxygenase superfamily 0.0002 PF00571 CBS domain 0.0002 PF00071 Ras family 0.0001 PF00266 Aminotransferase class-V 0.0001 PF00854 POT family 0.0001 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0001 PF00258 Flavodoxin 0.0001 PF00667 FAD binding domain SUB145 >= 1 saturated or aromatic carbon-only ring size 5 0.0912 PF02159 Oestrogen receptor 0.0774 PF02155 Glucocorticoid receptor 0.0772 PF00191 Annexin 0.0673 PF00105 Zinc finger, C4 type (two domains), 0.0671 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0661 PF02161 Progesterone receptor 0.0505 PF02166 Androgen receptor 0.0362 PF01735 Lysophospholipase catalytic domain 0.0300 PF00079 Serpin (serine protease inhibitor), 0.0144 PF00168 C2 domain 0.0115 PF12497 Estrogen receptor beta 0.0094 PF08035 Opioids neuropeptide 0.0094 PF08384 Pro-opiomelanocortin, N-terminal region 0.0094 PF00976 Corticotropin ACTH domain 0.0075 PF00690 Cation transporter/ATPase, N-terminus 0.0075 PF00689 Cation transporting ATPase, C-terminus 0.0067 PF00122 E1-E2 ATPase 0.0056 PF00702 haloacid dehalogenase-like hydrolase 0.0050 PF00554 Rel homology domain (RHD), 0.0050 PF07648 Kazal-type serine protease inhibitor domain 0.0050 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0049 PF00031 Cystatin domain 0.0049 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0047 PF00212 Atrial natriuretic peptide 0.0042 PF08377 MAP2/Tau projection domain 0.0042 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0036 PF00067 Cytochrome P450 0.0035 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0034 PF00704 Glycosyl hydrolases family 18 0.0034 PF01607 Chitin binding Peritrophin-A domain 0.0032 PF00039 Fibronectin type I domain 0.0029 PF02898 Nitric oxide synthase, oxygenase domain 0.0026 PF00531 Death domain 0.0026 PF00106 short chain dehydrogenase 0.0025 PF00762 Ferrochelatase 0.0022 PF09164 Vitamin D binding protein, domain III 0.0022 PF00654 Voltage gated chloride channel 0.0021 PF02180 Bcl-2 homology region 4 0.0021 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0017 PF00258 Flavodoxin 0.0017 PF00305 Lipoxygenase 0.0017 PF00667 FAD binding domain 0.0015 PF02038 ATP1G1/PLM/MAT8 family 0.0015 PF00884 Sulfatase 0.0014 PF00175 Oxidoreductase NAD-binding domain 0.0014 PF00432 Prenyltransferase and squalene oxidase repeat 0.0013 PF07884 Vitamin K epoxide reductase family 0.0009 PF00023 Ankyrin repeat 0.0007 PF00341 Platelet-derived growth factor (PDGF), 0.0006 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0006 PF01477 PLAT/LH2 domain 0.0006 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0006 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0006 PF00377 Prion/Doppel alpha-helical domain 0.0006 PF00969 Class II histocompatibility antigen, beta domain 0.0006 PF04756 OST3 / OST6 family 0.0006 PF02210 Laminin G domain 0.0005 PF01593 Flavin containing amine oxidoreductase 0.0003 PF00688 TGF-beta propeptide 0.0003 PF05193 Peptidase M16 inactive domain 0.0003 PF00714 Interferon gamma 0.0003 PF00675 Insulinase (Peptidase family M16), 0.0003 PF01429 Methyl-CpG binding domain 0.0003 PF00020 TNFR/NGFR cysteine-rich region 0.0003 PF00019 Transforming growth factor beta like domain 0.0002 PF02394 Interleukin-1 propeptide 0.0002 PF01431 Peptidase family M13 0.0002 PF05649 Peptidase family M13 0.0002 PF00340 Interleukin-1 / 18 0.0001 PF00656 Caspase domain 0.0001 PF01391 Collagen triple helix repeat (20 copies), SUB759 Cc1c(N)cccc1 0.0905 PF00204 DNA gyrase B 0.0905 PF08070 DTHCT (NUC029), region 0.0905 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0361 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0324 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0324 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0208 PF01735 Lysophospholipase catalytic domain 0.0171 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0165 PF00989 PAS fold 0.0165 PF00576 HIUase/Transthyretin family 0.0148 PF00191 Annexin 0.0134 PF00102 Protein-tyrosine phosphatase 0.0133 PF00689 Cation transporting ATPase, C-terminus 0.0133 PF00690 Cation transporter/ATPase, N-terminus 0.0132 PF00027 Cyclic nucleotide-binding domain 0.0130 PF00194 Eukaryotic-type carbonic anhydrase 0.0130 PF02155 Glucocorticoid receptor 0.0129 PF03073 TspO/MBR family 0.0122 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0117 PF00122 E1-E2 ATPase 0.0114 PF02166 Androgen receptor 0.0112 PF00520 Ion transport protein 0.0112 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0102 PF00303 Thymidylate synthase 0.0100 PF00702 haloacid dehalogenase-like hydrolase 0.0099 PF03477 ATP cone domain 0.0099 PF00317 Ribonucleotide reductase, all-alpha domain 0.0099 PF02867 Ribonucleotide reductase, barrel domain 0.0098 PF00079 Serpin (serine protease inhibitor), 0.0097 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0085 PF00146 NADH dehydrogenase 0.0082 PF01180 Dihydroorotate dehydrogenase 0.0077 PF02214 K+ channel tetramerisation domain 0.0076 PF00168 C2 domain 0.0072 PF01030 Receptor L domain 0.0072 PF00757 Furin-like cysteine rich region 0.0064 PF00136 DNA polymerase family B 0.0064 PF08996 DNA Polymerase alpha zinc finger 0.0064 PF03104 DNA polymerase family B, exonuclease domain 0.0060 PF03098 Animal haem peroxidase 0.0059 PF00248 Aldo/keto reductase family 0.0057 PF00493 MCM2/3/5 family 0.0056 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0049 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0047 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0042 PF05406 WGR domain 0.0042 PF08063 PADR1 (NUC008), domain 0.0042 PF00533 BRCA1 C Terminus (BRCT), domain 0.0042 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0042 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0042 PF00028 Cadherin domain 0.0040 PF02460 Patched family 0.0040 PF00069 Protein kinase domain 0.0036 PF03062 MBOAT family 0.0035 PF00654 Voltage gated chloride channel 0.0032 PF12491 Apolipoprotein B100 C terminal 0.0032 PF06448 Domain of Unknown Function (DUF1081), 0.0029 PF02196 Raf-like Ras-binding domain 0.0028 PF00489 Interleukin-6/G-CSF/MGF family 0.0027 PF01731 Arylesterase 0.0026 PF00229 TNF(Tumour Necrosis Factor), family 0.0021 PF02180 Bcl-2 homology region 4 0.0021 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0019 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0016 PF01347 Lipoprotein amino terminal region 0.0013 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0012 PF00554 Rel homology domain (RHD), 0.0010 PF00058 Low-density lipoprotein receptor repeat class B 0.0009 PF00042 Globin 0.0009 PF00406 Adenylate kinase 0.0008 PF01017 STAT protein, all-alpha domain 0.0008 PF01391 Collagen triple helix repeat (20 copies), 0.0008 PF02864 STAT protein, DNA binding domain 0.0008 PF02865 STAT protein, protein interaction domain 0.0008 PF00432 Prenyltransferase and squalene oxidase repeat 0.0008 PF08403 Amino acid permease N-terminal 0.0007 PF09396 Thrombin light chain 0.0006 PF00821 Phosphoenolpyruvate carboxykinase 0.0006 PF01596 O-methyltransferase 0.0005 PF00071 Ras family 0.0005 PF01061 ABC-2 type transporter 0.0003 PF01433 Peptidase family M1 0.0003 PF00656 Caspase domain 0.0002 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0001 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0001 PF07686 Immunoglobulin V-set domain 0.0001 PF00341 Platelet-derived growth factor (PDGF), SUB343 C(~C)(~Cl) 0.0893 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0893 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0847 PF03073 TspO/MBR family 0.0289 PF02254 TrkA-N domain 0.0289 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0280 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0277 PF00146 NADH dehydrogenase 0.0242 PF00194 Eukaryotic-type carbonic anhydrase 0.0179 PF08403 Amino acid permease N-terminal 0.0161 PF00690 Cation transporter/ATPase, N-terminus 0.0161 PF00689 Cation transporting ATPase, C-terminus 0.0140 PF00122 E1-E2 ATPase 0.0132 PF02888 Calmodulin binding domain 0.0132 PF03530 Calcium-activated SK potassium channel 0.0124 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0124 PF00631 GGL domain 0.0123 PF01007 Inward rectifier potassium channel 0.0120 PF00702 haloacid dehalogenase-like hydrolase 0.0116 PF00520 Ion transport protein 0.0112 PF00191 Annexin 0.0100 PF02214 K+ channel tetramerisation domain 0.0092 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0082 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0073 PF00343 Carbohydrate phosphorylase 0.0070 PF00209 Sodium:neurotransmitter symporter family 0.0065 PF00001 7 transmembrane receptor (rhodopsin family), 0.0064 PF00989 PAS fold 0.0058 PF12497 Estrogen receptor beta 0.0058 PF00273 Serum albumin family 0.0055 PF07885 Ion channel 0.0054 PF00018 SH3 domain 0.0053 PF00324 Amino acid permease 0.0053 PF02196 Raf-like Ras-binding domain 0.0050 PF00186 Dihydrofolate reductase 0.0049 PF00060 Ligand-gated ion channel 0.0049 PF00027 Cyclic nucleotide-binding domain 0.0045 PF00017 SH2 domain 0.0042 PF02155 Glucocorticoid receptor 0.0042 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0040 PF06512 Sodium ion transport-associated 0.0038 PF02159 Oestrogen receptor 0.0035 PF01094 Receptor family ligand binding region 0.0035 PF08919 F-actin binding 0.0030 PF00664 ABC transporter transmembrane region 0.0028 PF00612 IQ calmodulin-binding motif 0.0028 PF00243 Nerve growth factor family 0.0027 PF00005 ABC transporter 0.0026 PF00069 Protein kinase domain 0.0025 PF01404 Ephrin receptor ligand binding domain 0.0025 PF08377 MAP2/Tau projection domain 0.0025 PF00536 SAM domain (Sterile alpha motif), 0.0025 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0024 PF00079 Serpin (serine protease inhibitor), 0.0023 PF02008 CXXC zinc finger domain 0.0023 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0023 PF01426 BAH domain 0.0023 PF06464 DMAP1-binding Domain 0.0019 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0017 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0015 PF02865 STAT protein, protein interaction domain 0.0015 PF02864 STAT protein, DNA binding domain 0.0015 PF01017 STAT protein, all-alpha domain 0.0014 PF01030 Receptor L domain 0.0014 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0014 PF00757 Furin-like cysteine rich region 0.0013 PF03098 Animal haem peroxidase 0.0013 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0012 PF00145 C-5 cytosine-specific DNA methylase 0.0012 PF01234 NNMT/PNMT/TEMT family 0.0010 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0010 PF00305 Lipoxygenase 0.0009 PF03630 Fumble 0.0009 PF02060 Slow voltage-gated potassium channel 0.0009 PF01477 PLAT/LH2 domain 0.0009 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0009 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0009 PF02038 ATP1G1/PLM/MAT8 family 0.0009 PF00462 Glutaredoxin 0.0009 PF01734 Patatin-like phospholipase 0.0008 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0007 PF00576 HIUase/Transthyretin family 0.0007 PF00067 Cytochrome P450 0.0007 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0006 PF02743 Cache domain 0.0006 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0006 PF08399 VWA N-terminal 0.0005 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0005 PF00102 Protein-tyrosine phosphatase 0.0005 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0004 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0004 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0004 PF08063 PADR1 (NUC008), domain 0.0004 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0004 PF00533 BRCA1 C Terminus (BRCT), domain 0.0004 PF05406 WGR domain 0.0004 PF01735 Lysophospholipase catalytic domain 0.0003 PF07686 Immunoglobulin V-set domain 0.0003 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0003 PF00105 Zinc finger, C4 type (two domains), 0.0003 PF08070 DTHCT (NUC029), region 0.0003 PF02166 Androgen receptor 0.0003 PF03520 KCNQ voltage-gated potassium channel 0.0003 PF00042 Globin 0.0003 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0003 PF00204 DNA gyrase B 0.0002 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0002 PF05193 Peptidase M16 inactive domain 0.0002 PF01582 TIR domain 0.0002 PF00675 Insulinase (Peptidase family M16), 0.0002 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0002 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0001 PF00858 Amiloride-sensitive sodium channel 0.0001 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0001 PF00976 Corticotropin ACTH domain 0.0001 PF08384 Pro-opiomelanocortin, N-terminal region 0.0001 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0001 PF08035 Opioids neuropeptide 0.0001 PF00303 Thymidylate synthase SUB480 S-C-S-C 0.0891 PF00194 Eukaryotic-type carbonic anhydrase 0.0208 PF08403 Amino acid permease N-terminal 0.0127 PF03953 Tubulin C-terminal domain 0.0127 PF00091 Tubulin/FtsZ family, GTPase domain 0.0123 PF02254 TrkA-N domain 0.0123 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0111 PF01471 Putative peptidoglycan binding domain 0.0111 PF00045 Hemopexin 0.0102 PF00413 Matrixin 0.0100 PF01007 Inward rectifier potassium channel 0.0096 PF00324 Amino acid permease 0.0093 PF00001 7 transmembrane receptor (rhodopsin family), 0.0087 PF00043 Glutathione S-transferase, C-terminal domain 0.0087 PF02798 Glutathione S-transferase, N-terminal domain 0.0081 PF00102 Protein-tyrosine phosphatase 0.0058 PF00690 Cation transporter/ATPase, N-terminus 0.0058 PF00689 Cation transporting ATPase, C-terminus 0.0054 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0049 PF00122 E1-E2 ATPase 0.0045 PF01590 GAF domain 0.0040 PF00664 ABC transporter transmembrane region 0.0037 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0036 PF00702 haloacid dehalogenase-like hydrolase 0.0035 PF08983 Domain of unknown function (DUF1856), 0.0034 PF00005 ABC transporter 0.0033 PF00156 Phosphoribosyl transferase domain 0.0030 PF00478 IMP dehydrogenase / GMP reductase domain 0.0030 PF00255 Glutathione peroxidase 0.0030 PF00854 POT family 0.0029 PF09396 Thrombin light chain 0.0028 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0027 PF00962 Adenosine/AMP deaminase 0.0027 PF01770 Reduced folate carrier 0.0025 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0025 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0023 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0023 PF02772 S-adenosylmethionine synthetase, central domain 0.0023 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0022 PF03098 Animal haem peroxidase 0.0021 PF10397 Adenylosuccinate lyase C-terminus 0.0020 PF04679 ATP dependent DNA ligase C terminal region 0.0020 PF01068 ATP dependent DNA ligase domain 0.0020 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0016 PF12497 Estrogen receptor beta 0.0015 PF11857 Domain of unknown function (DUF3377), 0.0015 PF00108 Thiolase, N-terminal domain 0.0015 PF02803 Thiolase, C-terminal domain 0.0015 PF02785 Biotin carboxylase C-terminal domain 0.0014 PF00656 Caspase domain 0.0014 PF01124 MAPEG family 0.0013 PF08912 Rho Binding 0.0013 PF08441 Integrin alpha 0.0013 PF02185 Hr1 repeat 0.0013 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0012 PF00002 7 transmembrane receptor (Secretin family), 0.0012 PF01039 Carboxyl transferase domain 0.0012 PF00245 Alkaline phosphatase 0.0012 PF00167 Fibroblast growth factor 0.0012 PF02793 Hormone receptor domain 0.0012 PF04321 RmlD substrate binding domain 0.0011 PF02060 Slow voltage-gated potassium channel 0.0011 PF00364 Biotin-requiring enzyme 0.0011 PF08725 Integrin beta cytoplasmic domain 0.0011 PF00958 GMP synthase C terminal domain 0.0011 PF01323 DSBA-like thioredoxin domain 0.0010 PF05649 Peptidase family M13 0.0010 PF01431 Peptidase family M13 0.0009 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0009 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0009 PF02574 Homocysteine S-methyltransferase 0.0009 PF00206 Lyase 0.0009 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0008 PF00273 Serum albumin family 0.0008 PF02038 ATP1G1/PLM/MAT8 family 0.0007 PF03099 Biotin/lipoate A/B protein ligase family 0.0007 PF00357 Integrin alpha cytoplasmic region 0.0006 PF08326 Acetyl-CoA carboxylase, central region 0.0006 PF00362 Integrin, beta chain 0.0006 PF00581 Rhodanese-like domain 0.0006 PF01641 SelR domain 0.0006 PF09334 tRNA synthetases class I (M), 0.0006 PF07965 Integrin beta tail domain 0.0006 PF01406 tRNA synthetases class I (C), catalytic domain 0.0006 PF06617 M-phase inducer phosphatase 0.0005 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0005 PF02146 Sir2 family 0.0005 PF01234 NNMT/PNMT/TEMT family 0.0004 PF00112 Papain family cysteine protease 0.0004 PF10420 Cytokine interleukin-12p40 C-terminus 0.0004 PF00230 Major intrinsic protein 0.0003 PF01916 Deoxyhypusine synthase 0.0003 PF00474 Sodium:solute symporter family 0.0002 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0002 PF03199 Eukaryotic glutathione synthase 0.0002 PF05995 Cysteine dioxygenase type I 0.0002 PF08919 F-actin binding 0.0001 PF00020 TNFR/NGFR cysteine-rich region 0.0001 PF01731 Arylesterase 0.0001 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0001 PF00778 DIX domain 0.0001 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0001 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF04055 Radical SAM superfamily 0.0001 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0001 PF08833 Axin beta-catenin binding domain SUB336 C(~C)(~C)(~C)(~H) 0.0884 PF02159 Oestrogen receptor 0.0657 PF00105 Zinc finger, C4 type (two domains), 0.0646 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0338 PF00191 Annexin 0.0324 PF00001 7 transmembrane receptor (rhodopsin family), 0.0321 PF02155 Glucocorticoid receptor 0.0316 PF00204 DNA gyrase B 0.0316 PF08070 DTHCT (NUC029), region 0.0316 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0232 PF02161 Progesterone receptor 0.0174 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0169 PF00091 Tubulin/FtsZ family, GTPase domain 0.0169 PF03953 Tubulin C-terminal domain 0.0167 PF01735 Lysophospholipase catalytic domain 0.0162 PF00079 Serpin (serine protease inhibitor), 0.0127 PF00005 ABC transporter 0.0123 PF00989 PAS fold 0.0121 PF08384 Pro-opiomelanocortin, N-terminal region 0.0121 PF12497 Estrogen receptor beta 0.0121 PF08035 Opioids neuropeptide 0.0121 PF00976 Corticotropin ACTH domain 0.0120 PF02166 Androgen receptor 0.0113 PF00664 ABC transporter transmembrane region 0.0103 PF00027 Cyclic nucleotide-binding domain 0.0085 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0075 PF00168 C2 domain 0.0066 PF00273 Serum albumin family 0.0054 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0053 PF03414 Glycosyltransferase family 6 0.0052 PF01477 PLAT/LH2 domain 0.0048 PF00822 PMP-22/EMP/MP20/Claudin family 0.0043 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0039 PF00067 Cytochrome P450 0.0036 PF02806 Alpha amylase, C-terminal all-beta domain 0.0030 PF03098 Animal haem peroxidase 0.0029 PF07966 A1 Propeptide 0.0028 PF11825 Protein of unknown function (DUF3345), 0.0024 PF01401 Angiotensin-converting enzyme 0.0022 PF00026 Eukaryotic aspartyl protease 0.0020 PF00305 Lipoxygenase 0.0016 PF07648 Kazal-type serine protease inhibitor domain 0.0014 PF00151 Lipase 0.0013 PF00183 Hsp90 protein 0.0009 PF01061 ABC-2 type transporter 0.0009 PF02394 Interleukin-1 propeptide 0.0009 PF00340 Interleukin-1 / 18 0.0008 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0008 PF00059 Lectin C-type domain 0.0008 PF08763 Voltage gated calcium channel IQ domain 0.0006 PF08441 Integrin alpha 0.0005 PF00643 B-box zinc finger 0.0005 PF00229 TNF(Tumour Necrosis Factor), family 0.0003 PF00128 Alpha amylase, catalytic domain 0.0002 PF03765 CRAL/TRIO, N-terminus 0.0002 PF00650 CRAL/TRIO domain 0.0002 PF08771 Rapamycin binding domain 0.0002 PF02260 FATC domain 0.0002 PF02259 FAT domain 0.0001 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0001 PF02180 Bcl-2 homology region 4 SUB576 O-C-C:C-O 0.0866 PF00204 DNA gyrase B 0.0866 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0866 PF08070 DTHCT (NUC029), region 0.0430 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0328 PF00102 Protein-tyrosine phosphatase 0.0220 PF01048 Phosphorylase superfamily 0.0212 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0141 PF00303 Thymidylate synthase 0.0128 PF01590 GAF domain 0.0120 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0108 PF02525 Flavodoxin-like fold 0.0103 PF05406 WGR domain 0.0103 PF08063 PADR1 (NUC008), domain 0.0103 PF00533 BRCA1 C Terminus (BRCT), domain 0.0103 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0103 PF00576 HIUase/Transthyretin family 0.0103 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0100 PF00821 Phosphoenolpyruvate carboxykinase 0.0097 PF01467 Cytidylyltransferase 0.0096 PF01268 Formate--tetrahydrofolate ligase 0.0091 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0091 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0086 PF01808 AICARFT/IMPCHase bienzyme 0.0083 PF00107 Zinc-binding dehydrogenase 0.0082 PF00106 short chain dehydrogenase 0.0080 PF08240 Alcohol dehydrogenase GroES-like domain 0.0075 PF00248 Aldo/keto reductase family 0.0074 PF00071 Ras family 0.0068 PF00858 Amiloride-sensitive sodium channel 0.0065 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0061 PF00186 Dihydrofolate reductase 0.0059 PF01652 Eukaryotic initiation factor 4E 0.0058 PF02223 Thymidylate kinase 0.0055 PF02142 MGS-like domain 0.0055 PF01370 NAD dependent epimerase/dehydratase family 0.0054 PF00183 Hsp90 protein 0.0050 PF03098 Animal haem peroxidase 0.0048 PF00227 Proteasome subunit 0.0047 PF03024 Folate receptor family 0.0043 PF00464 Serine hydroxymethyltransferase 0.0041 PF01571 Aminomethyltransferase folate-binding domain 0.0041 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0040 PF00551 Formyl transferase 0.0039 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0039 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0036 PF00171 Aldehyde dehydrogenase family 0.0035 PF01575 MaoC like domain 0.0035 PF02036 SCP-2 sterol transfer family 0.0035 PF02267 ADP-ribosyl cyclase 0.0034 PF00025 ADP-ribosylation factor family 0.0033 PF00493 MCM2/3/5 family 0.0030 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0030 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0030 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0029 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0029 PF00305 Lipoxygenase 0.0029 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0028 PF01061 ABC-2 type transporter 0.0027 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0027 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0024 PF02233 NAD(P), transhydrogenase beta subunit 0.0021 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0021 PF08919 F-actin binding 0.0020 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0019 PF00822 PMP-22/EMP/MP20/Claudin family 0.0019 PF02219 Methylenetetrahydrofolate reductase 0.0019 PF00018 SH3 domain 0.0017 PF01180 Dihydroorotate dehydrogenase 0.0017 PF00999 Sodium/hydrogen exchanger family 0.0017 PF01731 Arylesterase 0.0017 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0017 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0017 PF00017 SH2 domain 0.0016 PF02059 Interleukin-3 0.0016 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0016 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0015 PF03360 Glycosyltransferase family 43 0.0015 PF00028 Cadherin domain 0.0014 PF06448 Domain of Unknown Function (DUF1081), 0.0014 PF12491 Apolipoprotein B100 C terminal 0.0013 PF00571 CBS domain 0.0013 PF00550 Phosphopantetheine attachment site 0.0013 PF00478 IMP dehydrogenase / GMP reductase domain 0.0012 PF01023 S-100/ICaBP type calcium binding domain 0.0011 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0011 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0010 PF00390 Malic enzyme, N-terminal domain 0.0010 PF02769 AIR synthase related protein, C-terminal domain 0.0010 PF00586 AIR synthase related protein, N-terminal domain 0.0010 PF10420 Cytokine interleukin-12p40 C-terminus 0.0010 PF02911 Formyl transferase, C-terminal domain 0.0010 PF03949 Malic enzyme, NAD binding domain 0.0009 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0009 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0008 PF00377 Prion/Doppel alpha-helical domain 0.0008 PF07722 Peptidase C26 0.0007 PF01227 GTP cyclohydrolase I 0.0007 PF01404 Ephrin receptor ligand binding domain 0.0007 PF00536 SAM domain (Sterile alpha motif), 0.0007 PF01347 Lipoprotein amino terminal region 0.0006 PF08403 Amino acid permease N-terminal 0.0006 PF00264 Common central domain of tyrosinase 0.0005 PF00927 Transglutaminase family, C-terminal ig like domain 0.0005 PF00341 Platelet-derived growth factor (PDGF), 0.0005 PF01841 Transglutaminase-like superfamily 0.0005 PF00868 Transglutaminase family 0.0005 PF00656 Caspase domain 0.0005 PF00654 Voltage gated chloride channel 0.0004 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0004 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0003 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0002 PF01916 Deoxyhypusine synthase 0.0002 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0002 PF00340 Interleukin-1 / 18 0.0002 PF02394 Interleukin-1 propeptide 0.0002 PF00676 Dehydrogenase E1 component 0.0001 PF00385 chromo (CHRromatin Organisation MOdifier), domain SUB779 CC1CCC(S)CC1 0.0864 PF00194 Eukaryotic-type carbonic anhydrase 0.0289 PF08403 Amino acid permease N-terminal 0.0289 PF02254 TrkA-N domain 0.0289 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0142 PF00324 Amino acid permease 0.0107 PF00689 Cation transporting ATPase, C-terminus 0.0107 PF00690 Cation transporter/ATPase, N-terminus 0.0095 PF00122 E1-E2 ATPase 0.0085 PF00702 haloacid dehalogenase-like hydrolase 0.0065 PF01007 Inward rectifier potassium channel 0.0053 PF00102 Protein-tyrosine phosphatase 0.0052 PF00520 Ion transport protein 0.0048 PF02146 Sir2 family 0.0041 PF10420 Cytokine interleukin-12p40 C-terminus 0.0038 PF01916 Deoxyhypusine synthase 0.0036 PF01471 Putative peptidoglycan binding domain 0.0036 PF00045 Hemopexin 0.0033 PF00413 Matrixin 0.0032 PF09396 Thrombin light chain 0.0028 PF02038 ATP1G1/PLM/MAT8 family 0.0028 PF02803 Thiolase, C-terminal domain 0.0028 PF00108 Thiolase, N-terminal domain 0.0027 PF00040 Fibronectin type II domain 0.0023 PF00043 Glutathione S-transferase, C-terminal domain 0.0022 PF00069 Protein kinase domain 0.0022 PF02798 Glutathione S-transferase, N-terminal domain 0.0021 PF08983 Domain of unknown function (DUF1856), 0.0015 PF00273 Serum albumin family 0.0015 PF00186 Dihydrofolate reductase 0.0012 PF00167 Fibroblast growth factor 0.0011 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0008 PF08702 Fibrinogen alpha/beta chain family 0.0008 PF04679 ATP dependent DNA ligase C terminal region 0.0008 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0008 PF11857 Domain of unknown function (DUF3377), 0.0008 PF01068 ATP dependent DNA ligase domain 0.0008 PF00664 ABC transporter transmembrane region 0.0007 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0006 PF00002 7 transmembrane receptor (Secretin family), 0.0006 PF04055 Radical SAM superfamily 0.0006 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 0.0006 PF08833 Axin beta-catenin binding domain 0.0006 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 0.0006 PF03098 Animal haem peroxidase 0.0006 PF00184 Neurohypophysial hormones, C-terminal Domain 0.0006 PF00778 DIX domain 0.0006 PF02793 Hormone receptor domain 0.0005 PF00020 TNFR/NGFR cysteine-rich region 0.0005 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0005 PF00005 ABC transporter 0.0005 PF00051 Kringle domain 0.0004 PF00230 Major intrinsic protein 0.0004 PF12160 Fibrinogen alpha C domain 0.0004 PF00265 Thymidine kinase 0.0004 PF01731 Arylesterase 0.0004 PF01369 Sec7 domain 0.0004 PF08466 Inward rectifier potassium channel N-terminal 0.0003 PF00024 PAN domain 0.0003 PF03099 Biotin/lipoate A/B protein ligase family 0.0002 PF00474 Sodium:solute symporter family 0.0002 PF01462 Leucine rich repeat N-terminal domain 0.0002 PF00615 Regulator of G protein signaling domain 0.0001 PF00058 Low-density lipoprotein receptor repeat class B 0.0001 PF01234 NNMT/PNMT/TEMT family 0.0001 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain SUB364 C(~F)(~F) 0.0864 PF00689 Cation transporting ATPase, C-terminus 0.0864 PF00690 Cation transporter/ATPase, N-terminus 0.0770 PF00122 E1-E2 ATPase 0.0697 PF00702 haloacid dehalogenase-like hydrolase 0.0636 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0470 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0467 PF00146 NADH dehydrogenase 0.0269 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0269 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0267 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0267 PF02254 TrkA-N domain 0.0232 PF00194 Eukaryotic-type carbonic anhydrase 0.0188 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0188 PF00631 GGL domain 0.0187 PF02214 K+ channel tetramerisation domain 0.0185 PF02888 Calmodulin binding domain 0.0185 PF03530 Calcium-activated SK potassium channel 0.0154 PF00287 Sodium / potassium ATPase beta chain 0.0142 PF00091 Tubulin/FtsZ family, GTPase domain 0.0142 PF03953 Tubulin C-terminal domain 0.0140 PF00191 Annexin 0.0137 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0115 PF01007 Inward rectifier potassium channel 0.0110 PF12497 Estrogen receptor beta 0.0099 PF00520 Ion transport protein 0.0094 PF00273 Serum albumin family 0.0079 PF07885 Ion channel 0.0073 PF00060 Ligand-gated ion channel 0.0068 PF08403 Amino acid permease N-terminal 0.0055 PF02155 Glucocorticoid receptor 0.0050 PF02159 Oestrogen receptor 0.0049 PF01094 Receptor family ligand binding region 0.0046 PF00102 Protein-tyrosine phosphatase 0.0044 PF00230 Major intrinsic protein 0.0040 PF00258 Flavodoxin 0.0040 PF00175 Oxidoreductase NAD-binding domain 0.0040 PF00667 FAD binding domain 0.0039 PF02898 Nitric oxide synthase, oxygenase domain 0.0039 PF08377 MAP2/Tau projection domain 0.0039 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0038 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0038 PF00017 SH2 domain 0.0037 PF00018 SH3 domain 0.0034 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0031 PF00079 Serpin (serine protease inhibitor), 0.0031 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0030 PF02008 CXXC zinc finger domain 0.0030 PF01426 BAH domain 0.0030 PF06464 DMAP1-binding Domain 0.0029 PF01068 ATP dependent DNA ligase domain 0.0029 PF03073 TspO/MBR family 0.0029 PF04679 ATP dependent DNA ligase C terminal region 0.0028 PF01770 Reduced folate carrier 0.0027 PF00478 IMP dehydrogenase / GMP reductase domain 0.0026 PF08919 F-actin binding 0.0025 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0025 PF01122 Eukaryotic cobalamin-binding protein 0.0024 PF00962 Adenosine/AMP deaminase 0.0021 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0019 PF00536 SAM domain (Sterile alpha motif), 0.0019 PF01404 Ephrin receptor ligand binding domain 0.0019 PF10397 Adenylosuccinate lyase C-terminus 0.0018 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0018 PF03308 ArgK protein 0.0018 PF01642 Methylmalonyl-CoA mutase 0.0018 PF00854 POT family 0.0018 PF01923 Cobalamin adenosyltransferase 0.0018 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0017 PF00156 Phosphoribosyl transferase domain 0.0017 PF00324 Amino acid permease 0.0016 PF02310 B12 binding domain 0.0016 PF00145 C-5 cytosine-specific DNA methylase 0.0016 PF01687 Riboflavin kinase 0.0016 PF00958 GMP synthase C terminal domain 0.0015 PF00576 HIUase/Transthyretin family 0.0014 PF00792 Phosphoinositide 3-kinase C2 0.0014 PF00462 Glutaredoxin 0.0014 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0014 PF00794 PI3-kinase family, ras-binding domain 0.0014 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0014 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0013 PF02864 STAT protein, DNA binding domain 0.0013 PF02865 STAT protein, protein interaction domain 0.0013 PF01017 STAT protein, all-alpha domain 0.0012 PF00206 Lyase 0.0010 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0009 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0009 PF01403 Sema domain 0.0009 PF01437 Plexin repeat 0.0009 PF02441 Flavoprotein 0.0009 PF01833 IPT/TIG domain 0.0008 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0008 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0008 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0008 PF00571 CBS domain 0.0008 PF00489 Interleukin-6/G-CSF/MGF family 0.0008 PF00654 Voltage gated chloride channel 0.0007 PF00459 Inositol monophosphatase family 0.0007 PF00069 Protein kinase domain 0.0007 PF00245 Alkaline phosphatase 0.0007 PF00970 Oxidoreductase FAD-binding domain 0.0007 PF00709 Adenylosuccinate synthetase 0.0006 PF00625 Guanylate kinase 0.0006 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0006 PF00405 Transferrin 0.0006 PF00117 Glutamine amidotransferase class-I 0.0005 PF02196 Raf-like Ras-binding domain 0.0005 PF00809 Pterin binding enzyme 0.0005 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0005 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0005 PF02607 B12 binding domain 0.0005 PF08063 PADR1 (NUC008), domain 0.0005 PF01180 Dihydroorotate dehydrogenase 0.0005 PF01735 Lysophospholipase catalytic domain 0.0005 PF05406 WGR domain 0.0005 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0005 PF00779 BTK motif 0.0005 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0005 PF00533 BRCA1 C Terminus (BRCT), domain 0.0005 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0005 PF07677 A-macroglobulin receptor 0.0005 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0005 PF07678 A-macroglobulin complement component 0.0005 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0005 PF01835 MG2 domain 0.0004 PF00134 Cyclin, N-terminal domain 0.0004 PF00204 DNA gyrase B 0.0004 PF00105 Zinc finger, C4 type (two domains), 0.0004 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0004 PF08070 DTHCT (NUC029), region 0.0004 PF12126 Protein of unknown function (DUF3583), 0.0004 PF00994 Probable molybdopterin binding domain 0.0004 PF02828 L27 domain 0.0004 PF07970 Endoplasmic reticulum vesicle transporter 0.0004 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0004 PF00431 CUB domain 0.0004 PF03453 MoeA N-terminal region (domain I and II), 0.0004 PF03454 MoeA C-terminal region (domain IV), 0.0004 PF02984 Cyclin, C-terminal domain 0.0004 PF00303 Thymidylate synthase 0.0004 PF00514 Armadillo/beta-catenin-like repeat 0.0003 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0003 PF01369 Sec7 domain 0.0003 PF00989 PAS fold 0.0003 PF00310 Glutamine amidotransferases class-II 0.0003 PF08399 VWA N-terminal 0.0003 PF02743 Cache domain 0.0003 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0003 PF02166 Androgen receptor 0.0003 PF00089 Trypsin 0.0002 PF00042 Globin 0.0002 PF00041 Fibronectin type III domain 0.0002 PF00406 Adenylate kinase 0.0002 PF05193 Peptidase M16 inactive domain 0.0002 PF07653 Variant SH3 domain 0.0002 PF08763 Voltage gated calcium channel IQ domain 0.0002 PF00675 Insulinase (Peptidase family M16), 0.0001 PF02189 Immunoreceptor tyrosine-based activation motif 0.0001 PF00027 Cyclic nucleotide-binding domain 0.0001 PF00581 Rhodanese-like domain 0.0001 PF06617 M-phase inducer phosphatase 0.0001 PF01733 Nucleoside transporter 0.0001 PF02525 Flavodoxin-like fold 0.0001 PF03957 Jun-like transcription factor 0.0001 PF11628 T-cell surface glycoprotein CD3 zeta chain SUB295 C-Cl 0.0862 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0862 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0830 PF03073 TspO/MBR family 0.0341 PF02254 TrkA-N domain 0.0341 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0313 PF00194 Eukaryotic-type carbonic anhydrase 0.0312 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0309 PF00146 NADH dehydrogenase 0.0222 PF08403 Amino acid permease N-terminal 0.0181 PF00690 Cation transporter/ATPase, N-terminus 0.0181 PF00689 Cation transporting ATPase, C-terminus 0.0158 PF00122 E1-E2 ATPase 0.0148 PF03530 Calcium-activated SK potassium channel 0.0148 PF02888 Calmodulin binding domain 0.0138 PF00631 GGL domain 0.0138 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0135 PF00702 haloacid dehalogenase-like hydrolase 0.0133 PF01007 Inward rectifier potassium channel 0.0132 PF00520 Ion transport protein 0.0122 PF00191 Annexin 0.0112 PF02214 K+ channel tetramerisation domain 0.0104 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0092 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0081 PF00209 Sodium:neurotransmitter symporter family 0.0076 PF00001 7 transmembrane receptor (rhodopsin family), 0.0068 PF00324 Amino acid permease 0.0065 PF00273 Serum albumin family 0.0064 PF12497 Estrogen receptor beta 0.0063 PF00343 Carbohydrate phosphorylase 0.0061 PF07885 Ion channel 0.0060 PF00989 PAS fold 0.0058 PF00018 SH3 domain 0.0054 PF00060 Ligand-gated ion channel 0.0051 PF00186 Dihydrofolate reductase 0.0050 PF02196 Raf-like Ras-binding domain 0.0048 PF00017 SH2 domain 0.0047 PF02155 Glucocorticoid receptor 0.0045 PF00027 Cyclic nucleotide-binding domain 0.0043 PF02159 Oestrogen receptor 0.0041 PF06512 Sodium ion transport-associated 0.0040 PF01094 Receptor family ligand binding region 0.0037 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0036 PF08919 F-actin binding 0.0034 PF00069 Protein kinase domain 0.0033 PF00664 ABC transporter transmembrane region 0.0030 PF00005 ABC transporter 0.0028 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0028 PF08377 MAP2/Tau projection domain 0.0028 PF00612 IQ calmodulin-binding motif 0.0028 PF00243 Nerve growth factor family 0.0026 PF00079 Serpin (serine protease inhibitor), 0.0025 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0025 PF01404 Ephrin receptor ligand binding domain 0.0025 PF02008 CXXC zinc finger domain 0.0025 PF01426 BAH domain 0.0025 PF06464 DMAP1-binding Domain 0.0025 PF00536 SAM domain (Sterile alpha motif), 0.0023 PF00757 Furin-like cysteine rich region 0.0023 PF01030 Receptor L domain 0.0022 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0022 PF03098 Animal haem peroxidase 0.0019 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0017 PF00305 Lipoxygenase 0.0016 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0016 PF01477 PLAT/LH2 domain 0.0016 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0014 PF02864 STAT protein, DNA binding domain 0.0014 PF01017 STAT protein, all-alpha domain 0.0014 PF02865 STAT protein, protein interaction domain 0.0013 PF02038 ATP1G1/PLM/MAT8 family 0.0013 PF03630 Fumble 0.0013 PF02060 Slow voltage-gated potassium channel 0.0013 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0013 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0013 PF01734 Patatin-like phospholipase 0.0013 PF00145 C-5 cytosine-specific DNA methylase 0.0012 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0011 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0011 PF00067 Cytochrome P450 0.0010 PF00462 Glutaredoxin 0.0010 PF01234 NNMT/PNMT/TEMT family 0.0009 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0008 PF00576 HIUase/Transthyretin family 0.0007 PF08063 PADR1 (NUC008), domain 0.0007 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0007 PF05406 WGR domain 0.0007 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0007 PF00533 BRCA1 C Terminus (BRCT), domain 0.0006 PF00102 Protein-tyrosine phosphatase 0.0005 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0005 PF02743 Cache domain 0.0005 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0005 PF00042 Globin 0.0005 PF08399 VWA N-terminal 0.0005 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0004 PF00388 Phosphatidylinositol-specific phospholipase C, X domain 0.0004 PF00387 Phosphatidylinositol-specific phospholipase C, Y domain 0.0004 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0004 PF00105 Zinc finger, C4 type (two domains), 0.0004 PF03520 KCNQ voltage-gated potassium channel 0.0004 PF01582 TIR domain 0.0004 PF01735 Lysophospholipase catalytic domain 0.0004 PF00675 Insulinase (Peptidase family M16), 0.0004 PF09279 Phosphoinositide-specific phospholipase C, efhand-like 0.0004 PF05193 Peptidase M16 inactive domain 0.0003 PF00204 DNA gyrase B 0.0003 PF02166 Androgen receptor 0.0003 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0003 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0003 PF07686 Immunoglobulin V-set domain 0.0003 PF08070 DTHCT (NUC029), region 0.0001 PF00858 Amiloride-sensitive sodium channel 0.0001 PF08035 Opioids neuropeptide 0.0001 PF00976 Corticotropin ACTH domain 0.0001 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0001 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0001 PF00303 Thymidylate synthase 0.0001 PF08384 Pro-opiomelanocortin, N-terminal region SUB451 C(-N)(=N) 0.0849 PF00186 Dihydrofolate reductase 0.0561 PF01048 Phosphorylase superfamily 0.0450 PF00478 IMP dehydrogenase / GMP reductase domain 0.0400 PF00069 Protein kinase domain 0.0349 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0257 PF03073 TspO/MBR family 0.0255 PF00571 CBS domain 0.0245 PF00962 Adenosine/AMP deaminase 0.0176 PF00156 Phosphoribosyl transferase domain 0.0159 PF01590 GAF domain 0.0145 PF00106 short chain dehydrogenase 0.0142 PF08240 Alcohol dehydrogenase GroES-like domain 0.0140 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0111 PF00018 SH3 domain 0.0111 PF00107 Zinc-binding dehydrogenase 0.0104 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0104 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0100 PF00017 SH2 domain 0.0099 PF08919 F-actin binding 0.0092 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0092 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0092 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0092 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0071 PF00858 Amiloride-sensitive sodium channel 0.0065 PF00171 Aldehyde dehydrogenase family 0.0063 PF09396 Thrombin light chain 0.0062 PF01030 Receptor L domain 0.0062 PF00757 Furin-like cysteine rich region 0.0058 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0056 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0056 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0052 PF01268 Formate--tetrahydrofolate ligase 0.0047 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0047 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0037 PF01687 Riboflavin kinase 0.0033 PF00821 Phosphoenolpyruvate carboxykinase 0.0028 PF00501 AMP-binding enzyme 0.0022 PF01808 AICARFT/IMPCHase bienzyme 0.0016 PF01122 Eukaryotic cobalamin-binding protein 0.0012 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0012 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0011 PF03477 ATP cone domain 0.0011 PF02867 Ribonucleotide reductase, barrel domain 0.0011 PF00317 Ribonucleotide reductase, all-alpha domain 0.0009 PF01923 Cobalamin adenosyltransferase 0.0009 PF03308 ArgK protein 0.0009 PF01642 Methylmalonyl-CoA mutase 0.0009 PF02267 ADP-ribosyl cyclase 0.0009 PF02310 B12 binding domain 0.0007 PF01467 Cytidylyltransferase 0.0007 PF02223 Thymidylate kinase 0.0005 PF00498 FHA domain 0.0005 PF02036 SCP-2 sterol transfer family 0.0005 PF01652 Eukaryotic initiation factor 4E 0.0005 PF01404 Ephrin receptor ligand binding domain 0.0005 PF08996 DNA Polymerase alpha zinc finger 0.0005 PF12473 Kinesin protein 0.0005 PF03104 DNA polymerase family B, exonuclease domain 0.0005 PF08676 MutL C terminal dimerisation domain 0.0005 PF01119 DNA mismatch repair protein, C-terminal domain 0.0005 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF01575 MaoC like domain 0.0005 PF00136 DNA polymerase family B 0.0005 PF00970 Oxidoreductase FAD-binding domain 0.0005 PF12423 Kinesin protein 1B 0.0005 PF10397 Adenylosuccinate lyase C-terminus 0.0005 PF00536 SAM domain (Sterile alpha motif), 0.0004 PF00809 Pterin binding enzyme 0.0004 PF00431 CUB domain 0.0004 PF00258 Flavodoxin 0.0004 PF00175 Oxidoreductase NAD-binding domain 0.0004 PF00667 FAD binding domain 0.0004 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0004 PF02607 B12 binding domain 0.0003 PF07645 Calcium-binding EGF domain 0.0002 PF02574 Homocysteine S-methyltransferase 0.0002 PF01230 HIT domain 0.0001 PF00248 Aldo/keto reductase family 0.0001 PF01126 Heme oxygenase SUB462 O-C-C=N 0.0844 PF00155 Aminotransferase class I and II 0.0809 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0799 PF00266 Aminotransferase class-V 0.0591 PF00464 Serine hydroxymethyltransferase 0.0528 PF00291 Pyridoxal-phosphate dependent enzyme 0.0503 PF00202 Aminotransferase class-III 0.0479 PF01063 Aminotransferase class IV 0.0465 PF00343 Carbohydrate phosphorylase 0.0390 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0390 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0333 PF00294 pfkB family carbohydrate kinase 0.0264 PF00702 haloacid dehalogenase-like hydrolase 0.0195 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0195 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0195 PF03476 MOSC N-terminal beta barrel domain 0.0195 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0195 PF03473 MOSC domain 0.0192 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0192 PF02347 Glycine cleavage system P-protein 0.0192 PF01168 Alanine racemase, N-terminal domain 0.0192 PF01212 Beta-eliminating lyase 0.0192 PF01202 Shikimate kinase 0.0189 PF04961 Formiminotransferase-cyclodeaminase 0.0189 PF02971 Formiminotransferase domain 0.0189 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0186 PF07706 Aminotransferase ubiquitination site 0.0140 PF01596 O-methyltransferase 0.0121 PF00571 CBS domain 0.0049 PF00340 Interleukin-1 / 18 0.0049 PF02394 Interleukin-1 propeptide 0.0044 PF00342 Phosphoglucose isomerase 0.0040 PF00690 Cation transporter/ATPase, N-terminus 0.0040 PF00689 Cation transporting ATPase, C-terminus 0.0032 PF00576 HIUase/Transthyretin family 0.0032 PF01588 Putative tRNA binding domain 0.0029 PF00122 E1-E2 ATPase 0.0028 PF01916 Deoxyhypusine synthase 0.0016 PF00204 DNA gyrase B 0.0016 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0016 PF08070 DTHCT (NUC029), region 0.0014 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0011 PF00149 Calcineurin-like phosphoesterase SUB710 C-C(C)-C-C-C 0.0841 PF00001 7 transmembrane receptor (rhodopsin family), 0.0705 PF02159 Oestrogen receptor 0.0591 PF00105 Zinc finger, C4 type (two domains), 0.0589 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0468 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0362 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0362 PF00204 DNA gyrase B 0.0362 PF08070 DTHCT (NUC029), region 0.0304 PF00209 Sodium:neurotransmitter symporter family 0.0249 PF03098 Animal haem peroxidase 0.0207 PF06512 Sodium ion transport-associated 0.0191 PF02161 Progesterone receptor 0.0178 PF00191 Annexin 0.0170 PF09396 Thrombin light chain 0.0156 PF00520 Ion transport protein 0.0133 PF02155 Glucocorticoid receptor 0.0128 PF00989 PAS fold 0.0112 PF03073 TspO/MBR family 0.0102 PF00067 Cytochrome P450 0.0096 PF00027 Cyclic nucleotide-binding domain 0.0090 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0089 PF02166 Androgen receptor 0.0063 PF03953 Tubulin C-terminal domain 0.0063 PF00091 Tubulin/FtsZ family, GTPase domain 0.0050 PF01735 Lysophospholipase catalytic domain 0.0048 PF00005 ABC transporter 0.0047 PF00102 Protein-tyrosine phosphatase 0.0047 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0043 PF12497 Estrogen receptor beta 0.0034 PF00186 Dihydrofolate reductase 0.0028 PF00664 ABC transporter transmembrane region 0.0028 PF00305 Lipoxygenase 0.0004 PF07884 Vitamin K epoxide reductase family SUB494 O=C-C:C 0.0803 PF00204 DNA gyrase B 0.0803 PF08070 DTHCT (NUC029), region 0.0803 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0598 PF03098 Animal haem peroxidase 0.0382 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0332 PF00191 Annexin 0.0292 PF00102 Protein-tyrosine phosphatase 0.0292 PF02155 Glucocorticoid receptor 0.0247 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0245 PF00105 Zinc finger, C4 type (two domains), 0.0241 PF00273 Serum albumin family 0.0165 PF07884 Vitamin K epoxide reductase family 0.0110 PF01735 Lysophospholipase catalytic domain 0.0110 PF02525 Flavodoxin-like fold 0.0104 PF00576 HIUase/Transthyretin family 0.0103 PF00005 ABC transporter 0.0099 PF01268 Formate--tetrahydrofolate ligase 0.0098 PF06512 Sodium ion transport-associated 0.0093 PF02161 Progesterone receptor 0.0091 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0091 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0084 PF00464 Serine hydroxymethyltransferase 0.0076 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0075 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0075 PF08063 PADR1 (NUC008), domain 0.0075 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0075 PF00533 BRCA1 C Terminus (BRCT), domain 0.0075 PF00079 Serpin (serine protease inhibitor), 0.0075 PF05406 WGR domain 0.0072 PF02166 Androgen receptor 0.0071 PF00664 ABC transporter transmembrane region 0.0068 PF09396 Thrombin light chain 0.0058 PF00089 Trypsin 0.0058 PF00051 Kringle domain 0.0056 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0055 PF01048 Phosphorylase superfamily 0.0053 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0053 PF00551 Formyl transferase 0.0052 PF00554 Rel homology domain (RHD), 0.0051 PF01061 ABC-2 type transporter 0.0045 PF08403 Amino acid permease N-terminal 0.0044 PF01571 Aminomethyltransferase folate-binding domain 0.0044 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0041 PF00017 SH2 domain 0.0038 PF11825 Protein of unknown function (DUF3345), 0.0036 PF00303 Thymidylate synthase 0.0032 PF01590 GAF domain 0.0032 PF01467 Cytidylyltransferase 0.0030 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0029 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0029 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0029 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0027 PF00018 SH3 domain 0.0026 PF00183 Hsp90 protein 0.0025 PF00821 Phosphoenolpyruvate carboxykinase 0.0024 PF02219 Methylenetetrahydrofolate reductase 0.0023 PF00248 Aldo/keto reductase family 0.0022 PF01808 AICARFT/IMPCHase bienzyme 0.0021 PF00106 short chain dehydrogenase 0.0021 PF00107 Zinc-binding dehydrogenase 0.0020 PF08240 Alcohol dehydrogenase GroES-like domain 0.0019 PF00071 Ras family 0.0018 PF00531 Death domain 0.0017 PF00858 Amiloride-sensitive sodium channel 0.0017 PF03024 Folate receptor family 0.0017 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0015 PF01652 Eukaryotic initiation factor 4E 0.0015 PF00186 Dihydrofolate reductase 0.0015 PF02223 Thymidylate kinase 0.0014 PF01370 NAD dependent epimerase/dehydratase family 0.0014 PF02142 MGS-like domain 0.0012 PF00229 TNF(Tumour Necrosis Factor), family 0.0012 PF00227 Proteasome subunit 0.0010 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0010 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0009 PF02036 SCP-2 sterol transfer family 0.0009 PF00025 ADP-ribosylation factor family 0.0009 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0009 PF00171 Aldehyde dehydrogenase family 0.0009 PF01575 MaoC like domain 0.0009 PF02267 ADP-ribosyl cyclase 0.0008 PF02911 Formyl transferase, C-terminal domain 0.0008 PF00493 MCM2/3/5 family 0.0007 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0007 PF00305 Lipoxygenase 0.0007 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0007 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0007 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0006 PF02233 NAD(P), transhydrogenase beta subunit 0.0006 PF00343 Carbohydrate phosphorylase 0.0005 PF08919 F-actin binding 0.0005 PF01180 Dihydroorotate dehydrogenase 0.0005 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0005 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0005 PF00822 PMP-22/EMP/MP20/Claudin family 0.0004 PF00028 Cadherin domain 0.0004 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0004 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0004 PF06448 Domain of Unknown Function (DUF1081), 0.0004 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0004 PF00999 Sodium/hydrogen exchanger family 0.0004 PF01731 Arylesterase 0.0004 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0004 PF02059 Interleukin-3 0.0004 PF12491 Apolipoprotein B100 C terminal 0.0004 PF03360 Glycosyltransferase family 43 0.0003 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0003 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0003 PF00571 CBS domain 0.0003 PF02769 AIR synthase related protein, C-terminal domain 0.0003 PF00478 IMP dehydrogenase / GMP reductase domain 0.0003 PF00586 AIR synthase related protein, N-terminal domain 0.0003 PF01023 S-100/ICaBP type calcium binding domain 0.0003 PF00550 Phosphopantetheine attachment site 0.0002 PF01347 Lipoprotein amino terminal region 0.0002 PF10420 Cytokine interleukin-12p40 C-terminus 0.0002 PF01404 Ephrin receptor ligand binding domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF07722 Peptidase C26 0.0002 PF01227 GTP cyclohydrolase I 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF00536 SAM domain (Sterile alpha motif), 0.0002 PF03949 Malic enzyme, NAD binding domain 0.0002 PF00377 Prion/Doppel alpha-helical domain 0.0002 PF00390 Malic enzyme, N-terminal domain 0.0001 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0001 PF00927 Transglutaminase family, C-terminal ig like domain 0.0001 PF00264 Common central domain of tyrosinase 0.0001 PF01841 Transglutaminase-like superfamily 0.0001 PF00868 Transglutaminase family 0.0001 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0001 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0001 PF00341 Platelet-derived growth factor (PDGF), 0.0001 PF00654 Voltage gated chloride channel 0.0001 PF00656 Caspase domain SUB685 O=C-C-C-C-C 0.0798 PF03098 Animal haem peroxidase 0.0603 PF00273 Serum albumin family 0.0474 PF00204 DNA gyrase B 0.0474 PF08070 DTHCT (NUC029), region 0.0474 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0441 PF01401 Angiotensin-converting enzyme 0.0298 PF00105 Zinc finger, C4 type (two domains), 0.0295 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0263 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0228 PF00576 HIUase/Transthyretin family 0.0217 PF00102 Protein-tyrosine phosphatase 0.0208 PF03953 Tubulin C-terminal domain 0.0208 PF00091 Tubulin/FtsZ family, GTPase domain 0.0182 PF00191 Annexin 0.0174 PF01063 Aminotransferase class IV 0.0171 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0139 PF00079 Serpin (serine protease inhibitor), 0.0125 PF02155 Glucocorticoid receptor 0.0113 PF01431 Peptidase family M13 0.0113 PF05649 Peptidase family M13 0.0095 PF00155 Aminotransferase class I and II 0.0090 PF11825 Protein of unknown function (DUF3345), 0.0078 PF00202 Aminotransferase class-III 0.0069 PF02798 Glutathione S-transferase, N-terminal domain 0.0066 PF00043 Glutathione S-transferase, C-terminal domain 0.0048 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0048 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0048 PF00464 Serine hydroxymethyltransferase 0.0048 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0040 PF02159 Oestrogen receptor 0.0036 PF09396 Thrombin light chain 0.0032 PF01268 Formate--tetrahydrofolate ligase 0.0028 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0026 PF01842 ACT domain 0.0024 PF00557 Metallopeptidase family M24 0.0022 PF02806 Alpha amylase, C-terminal all-beta domain 0.0022 PF00151 Lipase 0.0022 PF00303 Thymidylate synthase 0.0022 PF00733 Asparagine synthase 0.0021 PF01735 Lysophospholipase catalytic domain 0.0021 PF01126 Heme oxygenase 0.0020 PF00822 PMP-22/EMP/MP20/Claudin family 0.0020 PF00024 PAN domain 0.0019 PF02166 Androgen receptor 0.0014 PF02574 Homocysteine S-methyltransferase 0.0014 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0014 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0013 PF00375 Sodium:dicarboxylate symporter family 0.0013 PF00128 Alpha amylase, catalytic domain 0.0012 PF01490 Transmembrane amino acid transporter protein 0.0010 PF00490 Delta-aminolevulinic acid dehydratase 0.0010 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0010 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0010 PF00039 Fibronectin type I domain 0.0010 PF00764 Arginosuccinate synthase 0.0008 PF00255 Glutathione peroxidase 0.0007 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0007 PF03414 Glycosyltransferase family 6 0.0007 PF07706 Aminotransferase ubiquitination site 0.0006 PF00458 WHEP-TRS domain 0.0006 PF00248 Aldo/keto reductase family 0.0005 PF07648 Kazal-type serine protease inhibitor domain 0.0005 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0004 PF00175 Oxidoreductase NAD-binding domain 0.0004 PF00291 Pyridoxal-phosphate dependent enzyme 0.0004 PF04960 Glutaminase 0.0003 PF02898 Nitric oxide synthase, oxygenase domain 0.0002 PF03171 2OG-Fe(II), oxygenase superfamily 0.0002 PF00571 CBS domain 0.0002 PF00071 Ras family 0.0001 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0001 PF00266 Aminotransferase class-V 0.0001 PF00854 POT family 0.0001 PF00258 Flavodoxin 0.0001 PF00667 FAD binding domain SUB117 >= 1 saturated or aromatic carbon-only ring size 3 0.0792 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0792 PF00204 DNA gyrase B 0.0792 PF08070 DTHCT (NUC029), region 0.0389 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0272 PF00102 Protein-tyrosine phosphatase 0.0177 PF01048 Phosphorylase superfamily 0.0171 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0114 PF00303 Thymidylate synthase 0.0103 PF01590 GAF domain 0.0097 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0091 PF00576 HIUase/Transthyretin family 0.0088 PF02525 Flavodoxin-like fold 0.0083 PF00533 BRCA1 C Terminus (BRCT), domain 0.0083 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0083 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0083 PF08063 PADR1 (NUC008), domain 0.0083 PF05406 WGR domain 0.0080 PF00821 Phosphoenolpyruvate carboxykinase 0.0078 PF01467 Cytidylyltransferase 0.0077 PF01268 Formate--tetrahydrofolate ligase 0.0074 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0074 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0070 PF01808 AICARFT/IMPCHase bienzyme 0.0067 PF00107 Zinc-binding dehydrogenase 0.0066 PF00106 short chain dehydrogenase 0.0064 PF08240 Alcohol dehydrogenase GroES-like domain 0.0061 PF00071 Ras family 0.0060 PF00248 Aldo/keto reductase family 0.0055 PF00858 Amiloride-sensitive sodium channel 0.0053 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0050 PF00186 Dihydrofolate reductase 0.0048 PF01652 Eukaryotic initiation factor 4E 0.0046 PF02223 Thymidylate kinase 0.0045 PF00183 Hsp90 protein 0.0044 PF03098 Animal haem peroxidase 0.0044 PF02142 MGS-like domain 0.0044 PF01370 NAD dependent epimerase/dehydratase family 0.0039 PF00227 Proteasome subunit 0.0038 PF03024 Folate receptor family 0.0035 PF00464 Serine hydroxymethyltransferase 0.0033 PF01571 Aminomethyltransferase folate-binding domain 0.0033 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0032 PF00551 Formyl transferase 0.0032 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0032 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0029 PF00171 Aldehyde dehydrogenase family 0.0029 PF02267 ADP-ribosyl cyclase 0.0028 PF00025 ADP-ribosylation factor family 0.0028 PF01061 ABC-2 type transporter 0.0028 PF00493 MCM2/3/5 family 0.0028 PF02036 SCP-2 sterol transfer family 0.0028 PF01575 MaoC like domain 0.0026 PF00305 Lipoxygenase 0.0024 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0024 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0024 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0023 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0023 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0022 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0021 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0021 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0020 PF02233 NAD(P), transhydrogenase beta subunit 0.0020 PF08919 F-actin binding 0.0018 PF00018 SH3 domain 0.0018 PF00017 SH2 domain 0.0017 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0015 PF02059 Interleukin-3 0.0015 PF02219 Methylenetetrahydrofolate reductase 0.0015 PF00822 PMP-22/EMP/MP20/Claudin family 0.0015 PF01731 Arylesterase 0.0015 PF01180 Dihydroorotate dehydrogenase 0.0014 PF00999 Sodium/hydrogen exchanger family 0.0014 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0014 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0013 PF06448 Domain of Unknown Function (DUF1081), 0.0013 PF12491 Apolipoprotein B100 C terminal 0.0013 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0013 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0013 PF03360 Glycosyltransferase family 43 0.0012 PF00273 Serum albumin family 0.0012 PF01023 S-100/ICaBP type calcium binding domain 0.0012 PF00028 Cadherin domain 0.0011 PF03953 Tubulin C-terminal domain 0.0011 PF00550 Phosphopantetheine attachment site 0.0011 PF00478 IMP dehydrogenase / GMP reductase domain 0.0011 PF00571 CBS domain 0.0011 PF00091 Tubulin/FtsZ family, GTPase domain 0.0010 PF03949 Malic enzyme, NAD binding domain 0.0010 PF00390 Malic enzyme, N-terminal domain 0.0009 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0009 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0008 PF02911 Formyl transferase, C-terminal domain 0.0008 PF00586 AIR synthase related protein, N-terminal domain 0.0008 PF02769 AIR synthase related protein, C-terminal domain 0.0008 PF10420 Cytokine interleukin-12p40 C-terminus 0.0008 PF00377 Prion/Doppel alpha-helical domain 0.0007 PF07722 Peptidase C26 0.0007 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0007 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0007 PF01347 Lipoprotein amino terminal region 0.0006 PF01227 GTP cyclohydrolase I 0.0006 PF00536 SAM domain (Sterile alpha motif), 0.0006 PF09396 Thrombin light chain 0.0006 PF00341 Platelet-derived growth factor (PDGF), 0.0006 PF00005 ABC transporter 0.0006 PF00405 Transferrin 0.0006 PF00656 Caspase domain 0.0006 PF01404 Ephrin receptor ligand binding domain 0.0005 PF00654 Voltage gated chloride channel 0.0005 PF00264 Common central domain of tyrosinase 0.0004 PF08403 Amino acid permease N-terminal 0.0004 PF00754 F5/8 type C domain 0.0004 PF01841 Transglutaminase-like superfamily 0.0004 PF00927 Transglutaminase family, C-terminal ig like domain 0.0004 PF00868 Transglutaminase family 0.0004 PF07884 Vitamin K epoxide reductase family 0.0004 PF00664 ABC transporter transmembrane region 0.0003 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0003 PF02394 Interleukin-1 propeptide 0.0003 PF00340 Interleukin-1 / 18 0.0003 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0003 PF03957 Jun-like transcription factor 0.0003 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0003 PF01735 Lysophospholipase catalytic domain 0.0003 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0003 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0003 PF00079 Serpin (serine protease inhibitor), 0.0003 PF01187 Macrophage migration inhibitory factor (MIF), 0.0003 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0002 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0002 PF02259 FAT domain 0.0002 PF08659 KR domain 0.0002 PF00043 Glutathione S-transferase, C-terminal domain 0.0002 PF00155 Aminotransferase class I and II 0.0002 PF00040 Fibronectin type II domain 0.0002 PF00168 C2 domain 0.0002 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0002 PF02155 Glucocorticoid receptor 0.0002 PF00271 Helicase conserved C-terminal domain 0.0002 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0002 PF02260 FATC domain 0.0002 PF00291 Pyridoxal-phosphate dependent enzyme 0.0002 PF00229 TNF(Tumour Necrosis Factor), family 0.0002 PF00266 Aminotransferase class-V 0.0002 PF03171 2OG-Fe(II), oxygenase superfamily 0.0002 PF08771 Rapamycin binding domain 0.0002 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0002 PF00975 Thioesterase domain 0.0002 PF00108 Thiolase, N-terminal domain 0.0002 PF00989 PAS fold 0.0002 PF01477 PLAT/LH2 domain 0.0002 PF00698 Acyl transferase domain 0.0002 PF02798 Glutathione S-transferase, N-terminal domain 0.0002 PF02803 Thiolase, C-terminal domain 0.0002 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0001 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0001 PF01753 MYND finger 0.0001 PF02666 Phosphatidylserine decarboxylase 0.0001 PF01168 Alanine racemase, N-terminal domain 0.0001 PF00191 Annexin 0.0001 PF00058 Low-density lipoprotein receptor repeat class B 0.0001 PF00057 Low-density lipoprotein receptor domain class A 0.0001 PF03351 DOMON domain 0.0001 PF00051 Kringle domain 0.0001 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0001 PF02347 Glycine cleavage system P-protein 0.0001 PF02793 Hormone receptor domain 0.0001 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0001 PF07690 Major Facilitator Superfamily 0.0001 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0001 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0001 PF01596 O-methyltransferase 0.0001 PF07647 SAM domain (Sterile alpha motif), 0.0001 PF02180 Bcl-2 homology region 4 0.0001 PF00170 bZIP transcription factor 0.0001 PF03473 MOSC domain 0.0001 PF00342 Phosphoglucose isomerase 0.0001 PF00176 SNF2 family N-terminal domain 0.0001 PF00343 Carbohydrate phosphorylase 0.0001 PF03476 MOSC N-terminal beta barrel domain 0.0001 PF02824 TGS domain 0.0001 PF08742 C8 domain 0.0001 PF00676 Dehydrogenase E1 component 0.0001 PF04679 ATP dependent DNA ligase C terminal region 0.0001 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.0001 PF03623 Focal adhesion targeting region 0.0001 PF01212 Beta-eliminating lyase 0.0001 PF01425 Amidase 0.0001 PF01429 Methyl-CpG binding domain 0.0001 PF00246 Zinc carboxypeptidase 0.0001 PF03062 MBOAT family 0.0001 PF00969 Class II histocompatibility antigen, beta domain 0.0001 PF01437 Plexin repeat 0.0001 PF00094 von Willebrand factor type D domain 0.0001 PF02025 Interleukin 5 0.0001 PF00554 Rel homology domain (RHD), 0.0001 PF00755 Choline/Carnitine o-acyltransferase 0.0001 PF01130 CD36 family 0.0001 PF00027 Cyclic nucleotide-binding domain 0.0001 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0001 PF02928 C5HC2 zinc finger 0.0001 PF01202 Shikimate kinase 0.0001 PF01916 Deoxyhypusine synthase 0.0001 PF00860 Permease family 0.0001 PF00294 pfkB family carbohydrate kinase 0.0001 PF08429 PLU-1-like protein 0.0001 PF02375 jmjN domain 0.0001 PF02373 JmjC domain 0.0001 PF01391 Collagen triple helix repeat (20 copies), 0.0001 PF11404 Potassium voltage-gated channel 0.0001 PF09193 Cholecystokinin A receptor, N-terminal 0.0001 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0001 PF01388 ARID/BRIGHT DNA binding domain 0.0001 PF01403 Sema domain 0.0001 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0001 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0001 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0001 PF01068 ATP dependent DNA ligase domain 0.0001 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0001 PF00274 Fructose-bisphosphate aldolase class-I 0.0001 PF00002 7 transmembrane receptor (Secretin family), 0.0001 PF00609 Diacylglycerol kinase accessory domain 0.0001 PF00270 DEAD/DEAH box helicase 0.0001 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0001 PF02898 Nitric oxide synthase, oxygenase domain 0.0001 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0001 PF00628 PHD-finger 0.0001 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0001 PF00085 Thioredoxin 0.0001 PF02403 Seryl-tRNA synthetase N-terminal domain 0.0001 PF03034 Phosphatidyl serine synthase 0.0001 PF00717 Peptidase S24-like 0.0001 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0001 PF01833 IPT/TIG domain 0.0001 PF00781 Diacylglycerol kinase catalytic domain SUB798 CC1CC(C)CCC1 0.0791 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0791 PF00105 Zinc finger, C4 type (two domains), 0.0772 PF02159 Oestrogen receptor 0.0668 PF00191 Annexin 0.0626 PF02155 Glucocorticoid receptor 0.0548 PF02161 Progesterone receptor 0.0414 PF02166 Androgen receptor 0.0305 PF01735 Lysophospholipase catalytic domain 0.0252 PF00079 Serpin (serine protease inhibitor), 0.0217 PF00976 Corticotropin ACTH domain 0.0217 PF08384 Pro-opiomelanocortin, N-terminal region 0.0217 PF08035 Opioids neuropeptide 0.0151 PF00091 Tubulin/FtsZ family, GTPase domain 0.0151 PF03953 Tubulin C-terminal domain 0.0120 PF00168 C2 domain 0.0107 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0106 PF11825 Protein of unknown function (DUF3345), 0.0086 PF12497 Estrogen receptor beta 0.0058 PF01429 Methyl-CpG binding domain 0.0057 PF00106 short chain dehydrogenase 0.0057 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0056 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0053 PF00643 B-box zinc finger 0.0052 PF00305 Lipoxygenase 0.0050 PF07648 Kazal-type serine protease inhibitor domain 0.0047 PF08491 Squalene epoxidase 0.0046 PF00040 Fibronectin type II domain 0.0045 PF00067 Cytochrome P450 0.0043 PF06327 Domain of Unknown Function (DUF1053), 0.0041 PF02180 Bcl-2 homology region 4 0.0041 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0037 PF01122 Eukaryotic cobalamin-binding protein 0.0037 PF00918 Gastrin/cholecystokinin family 0.0036 PF00653 Inhibitor of Apoptosis domain 0.0036 PF01477 PLAT/LH2 domain 0.0033 PF04622 ERG2 and Sigma1 receptor like protein 0.0029 PF00170 bZIP transcription factor 0.0027 PF02173 pKID domain 0.0026 PF00212 Atrial natriuretic peptide 0.0026 PF00554 Rel homology domain (RHD), 0.0026 PF01160 Vertebrate endogenous opioids neuropeptide 0.0026 PF00031 Cystatin domain 0.0024 PF03765 CRAL/TRIO, N-terminus 0.0024 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0024 PF00650 CRAL/TRIO domain 0.0023 PF00656 Caspase domain 0.0023 PF01642 Methylmalonyl-CoA mutase 0.0023 PF01923 Cobalamin adenosyltransferase 0.0023 PF03308 ArgK protein 0.0022 PF00762 Ferrochelatase 0.0022 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0022 PF08377 MAP2/Tau projection domain 0.0017 PF02310 B12 binding domain 0.0016 PF00377 Prion/Doppel alpha-helical domain 0.0016 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0016 PF00884 Sulfatase 0.0015 PF06907 Latexin 0.0015 PF08070 DTHCT (NUC029), region 0.0015 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0015 PF00969 Class II histocompatibility antigen, beta domain 0.0015 PF00204 DNA gyrase B 0.0015 PF03572 Peptidase family S41 0.0015 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0015 PF00625 Guanylate kinase 0.0013 PF00183 Hsp90 protein 0.0013 PF00531 Death domain 0.0012 PF00340 Interleukin-1 / 18 0.0012 PF00341 Platelet-derived growth factor (PDGF), 0.0012 PF02394 Interleukin-1 propeptide 0.0011 PF08763 Voltage gated calcium channel IQ domain 0.0010 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0008 PF00489 Interleukin-6/G-CSF/MGF family 0.0008 PF00714 Interferon gamma 0.0007 PF00432 Prenyltransferase and squalene oxidase repeat 0.0007 PF00357 Integrin alpha cytoplasmic region 0.0007 PF03957 Jun-like transcription factor 0.0006 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0006 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0004 PF02803 Thiolase, C-terminal domain 0.0004 PF01327 Polypeptide deformylase 0.0004 PF00688 TGF-beta propeptide 0.0004 PF00439 Bromodomain 0.0004 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0004 PF01244 Membrane dipeptidase (Peptidase family M19), 0.0004 PF00019 Transforming growth factor beta like domain 0.0004 PF00890 FAD binding domain 0.0004 PF00108 Thiolase, N-terminal domain 0.0004 PF00020 TNFR/NGFR cysteine-rich region 0.0002 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0002 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0001 PF08441 Integrin alpha 0.0001 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0001 PF01425 Amidase SUB367 C(~H)(~O) 0.0782 PF00191 Annexin 0.0720 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0682 PF02806 Alpha amylase, C-terminal all-beta domain 0.0640 PF02155 Glucocorticoid receptor 0.0478 PF00128 Alpha amylase, catalytic domain 0.0464 PF03414 Glycosyltransferase family 6 0.0422 PF00079 Serpin (serine protease inhibitor), 0.0385 PF01048 Phosphorylase superfamily 0.0334 PF03953 Tubulin C-terminal domain 0.0334 PF00091 Tubulin/FtsZ family, GTPase domain 0.0294 PF02223 Thymidylate kinase 0.0241 PF01735 Lysophospholipase catalytic domain 0.0219 PF00303 Thymidylate synthase 0.0190 PF00106 short chain dehydrogenase 0.0156 PF00059 Lectin C-type domain 0.0153 PF00167 Fibroblast growth factor 0.0134 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0127 PF03770 Inositol polyphosphate kinase 0.0113 PF00005 ABC transporter 0.0108 PF01607 Chitin binding Peritrophin-A domain 0.0108 PF00704 Glycosyl hydrolases family 18 0.0098 PF01467 Cytidylyltransferase 0.0082 PF00664 ABC transporter transmembrane region 0.0082 PF00084 Sushi domain (SCR repeat), 0.0081 PF02267 ADP-ribosyl cyclase 0.0078 PF00171 Aldehyde dehydrogenase family 0.0075 PF00349 Hexokinase 0.0075 PF03727 Hexokinase 0.0073 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0073 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0071 PF07654 Immunoglobulin C1-set domain 0.0068 PF08035 Opioids neuropeptide 0.0068 PF08384 Pro-opiomelanocortin, N-terminal region 0.0068 PF00976 Corticotropin ACTH domain 0.0067 PF01370 NAD dependent epimerase/dehydratase family 0.0066 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.0056 PF01532 Glycosyl hydrolase family 47 0.0048 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0048 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0048 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0039 PF08240 Alcohol dehydrogenase GroES-like domain 0.0026 PF00248 Aldo/keto reductase family 0.0023 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0022 PF00107 Zinc-binding dehydrogenase 0.0021 PF00143 Interferon alpha/beta domain 0.0020 PF01687 Riboflavin kinase 0.0019 PF00071 Ras family 0.0014 PF01842 ACT domain 0.0013 PF01122 Eukaryotic cobalamin-binding protein 0.0013 PF01230 HIT domain 0.0011 PF00571 CBS domain 0.0008 PF03360 Glycosyltransferase family 43 0.0003 PF00088 Trefoil (P-type), domain 0.0003 PF01055 Glycosyl hydrolases family 31 SUB481 C:S:C-C 0.0779 PF00091 Tubulin/FtsZ family, GTPase domain 0.0779 PF03953 Tubulin C-terminal domain 0.0113 PF07884 Vitamin K epoxide reductase family 0.0104 PF00018 SH3 domain 0.0092 PF00017 SH2 domain 0.0090 PF01068 ATP dependent DNA ligase domain 0.0090 PF04679 ATP dependent DNA ligase C terminal region 0.0089 PF01770 Reduced folate carrier 0.0087 PF08919 F-actin binding 0.0078 PF00102 Protein-tyrosine phosphatase 0.0074 PF00194 Eukaryotic-type carbonic anhydrase 0.0063 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0062 PF01404 Ephrin receptor ligand binding domain 0.0062 PF00536 SAM domain (Sterile alpha motif), 0.0049 PF00854 POT family 0.0042 PF02865 STAT protein, protein interaction domain 0.0042 PF00478 IMP dehydrogenase / GMP reductase domain 0.0042 PF01017 STAT protein, all-alpha domain 0.0042 PF02864 STAT protein, DNA binding domain 0.0040 PF02059 Interleukin-3 0.0040 PF00183 Hsp90 protein 0.0040 PF00656 Caspase domain 0.0040 PF00377 Prion/Doppel alpha-helical domain 0.0039 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0038 PF00340 Interleukin-1 / 18 0.0038 PF02394 Interleukin-1 propeptide 0.0035 PF00962 Adenosine/AMP deaminase 0.0028 PF01023 S-100/ICaBP type calcium binding domain 0.0027 PF00156 Phosphoribosyl transferase domain 0.0027 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0026 PF00069 Protein kinase domain 0.0025 PF00020 TNFR/NGFR cysteine-rich region 0.0025 PF10397 Adenylosuccinate lyase C-terminus 0.0025 PF03098 Animal haem peroxidase 0.0022 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0022 PF00619 Caspase recruitment domain 0.0022 PF00958 GMP synthase C terminal domain 0.0021 PF00341 Platelet-derived growth factor (PDGF), 0.0021 PF02525 Flavodoxin-like fold 0.0019 PF00305 Lipoxygenase 0.0018 PF09396 Thrombin light chain 0.0018 PF00040 Fibronectin type II domain 0.0017 PF00041 Fibronectin type III domain 0.0017 PF12497 Estrogen receptor beta 0.0016 PF00206 Lyase 0.0016 PF00531 Death domain 0.0015 PF02155 Glucocorticoid receptor 0.0013 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0010 PF00001 7 transmembrane receptor (rhodopsin family), 0.0009 PF00273 Serum albumin family 0.0008 PF00709 Adenylosuccinate synthetase 0.0008 PF01477 PLAT/LH2 domain 0.0008 PF00117 Glutamine amidotransferase class-I 0.0007 PF00310 Glutamine amidotransferases class-II 0.0007 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0007 PF00245 Alkaline phosphatase 0.0006 PF00571 CBS domain 0.0006 PF00230 Major intrinsic protein 0.0005 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0005 PF00690 Cation transporter/ATPase, N-terminus 0.0005 PF00689 Cation transporting ATPase, C-terminus 0.0005 PF00287 Sodium / potassium ATPase beta chain 0.0005 PF01425 Amidase 0.0005 PF02254 TrkA-N domain 0.0004 PF01835 MG2 domain 0.0004 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0004 PF01731 Arylesterase 0.0004 PF07677 A-macroglobulin receptor 0.0004 PF07678 A-macroglobulin complement component 0.0003 PF00122 E1-E2 ATPase 0.0001 PF00675 Insulinase (Peptidase family M16), 0.0001 PF11857 Domain of unknown function (DUF3377), 0.0001 PF05193 Peptidase M16 inactive domain 0.0001 PF08403 Amino acid permease N-terminal 0.0001 PF00557 Metallopeptidase family M24 SUB720 Oc1ccc(O)cc1 0.0771 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0771 PF00204 DNA gyrase B 0.0771 PF08070 DTHCT (NUC029), region 0.0383 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0292 PF00102 Protein-tyrosine phosphatase 0.0196 PF01048 Phosphorylase superfamily 0.0189 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0126 PF00303 Thymidylate synthase 0.0114 PF01590 GAF domain 0.0107 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0096 PF02525 Flavodoxin-like fold 0.0092 PF00576 HIUase/Transthyretin family 0.0091 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0091 PF00533 BRCA1 C Terminus (BRCT), domain 0.0091 PF08063 PADR1 (NUC008), domain 0.0091 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0091 PF05406 WGR domain 0.0089 PF00821 Phosphoenolpyruvate carboxykinase 0.0087 PF01467 Cytidylyltransferase 0.0086 PF01268 Formate--tetrahydrofolate ligase 0.0081 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0081 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0077 PF01808 AICARFT/IMPCHase bienzyme 0.0074 PF00107 Zinc-binding dehydrogenase 0.0073 PF00106 short chain dehydrogenase 0.0071 PF08240 Alcohol dehydrogenase GroES-like domain 0.0067 PF00248 Aldo/keto reductase family 0.0066 PF00071 Ras family 0.0061 PF00858 Amiloride-sensitive sodium channel 0.0058 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0054 PF00186 Dihydrofolate reductase 0.0053 PF01652 Eukaryotic initiation factor 4E 0.0051 PF02223 Thymidylate kinase 0.0049 PF00183 Hsp90 protein 0.0049 PF01370 NAD dependent epimerase/dehydratase family 0.0049 PF02142 MGS-like domain 0.0045 PF03098 Animal haem peroxidase 0.0043 PF00227 Proteasome subunit 0.0042 PF03024 Folate receptor family 0.0038 PF00464 Serine hydroxymethyltransferase 0.0037 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0037 PF01571 Aminomethyltransferase folate-binding domain 0.0036 PF00551 Formyl transferase 0.0035 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0035 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0032 PF00171 Aldehyde dehydrogenase family 0.0032 PF02267 ADP-ribosyl cyclase 0.0031 PF01575 MaoC like domain 0.0031 PF02036 SCP-2 sterol transfer family 0.0030 PF00025 ADP-ribosylation factor family 0.0029 PF00493 MCM2/3/5 family 0.0026 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0026 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0026 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0026 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0026 PF00305 Lipoxygenase 0.0026 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0025 PF01061 ABC-2 type transporter 0.0024 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0024 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0022 PF02233 NAD(P), transhydrogenase beta subunit 0.0019 PF08919 F-actin binding 0.0018 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0018 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0017 PF02219 Methylenetetrahydrofolate reductase 0.0017 PF00018 SH3 domain 0.0017 PF00822 PMP-22/EMP/MP20/Claudin family 0.0016 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0016 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0015 PF00017 SH2 domain 0.0015 PF00999 Sodium/hydrogen exchanger family 0.0015 PF01731 Arylesterase 0.0015 PF01180 Dihydroorotate dehydrogenase 0.0015 PF02059 Interleukin-3 0.0014 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0014 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0013 PF12491 Apolipoprotein B100 C terminal 0.0013 PF00028 Cadherin domain 0.0013 PF06448 Domain of Unknown Function (DUF1081), 0.0013 PF03360 Glycosyltransferase family 43 0.0012 PF00571 CBS domain 0.0012 PF00550 Phosphopantetheine attachment site 0.0012 PF00478 IMP dehydrogenase / GMP reductase domain 0.0011 PF01023 S-100/ICaBP type calcium binding domain 0.0010 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0010 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0009 PF02911 Formyl transferase, C-terminal domain 0.0009 PF03949 Malic enzyme, NAD binding domain 0.0009 PF10420 Cytokine interleukin-12p40 C-terminus 0.0009 PF02769 AIR synthase related protein, C-terminal domain 0.0009 PF00586 AIR synthase related protein, N-terminal domain 0.0009 PF00390 Malic enzyme, N-terminal domain 0.0008 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0008 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0007 PF00377 Prion/Doppel alpha-helical domain 0.0007 PF07722 Peptidase C26 0.0006 PF00536 SAM domain (Sterile alpha motif), 0.0006 PF01347 Lipoprotein amino terminal region 0.0006 PF01404 Ephrin receptor ligand binding domain 0.0006 PF01227 GTP cyclohydrolase I 0.0005 PF00341 Platelet-derived growth factor (PDGF), 0.0005 PF08403 Amino acid permease N-terminal 0.0005 PF00264 Common central domain of tyrosinase 0.0004 PF00654 Voltage gated chloride channel 0.0004 PF00656 Caspase domain 0.0004 PF01841 Transglutaminase-like superfamily 0.0004 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0004 PF00868 Transglutaminase family 0.0004 PF00927 Transglutaminase family, C-terminal ig like domain 0.0004 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0003 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0002 PF00340 Interleukin-1 / 18 0.0002 PF02394 Interleukin-1 propeptide 0.0001 PF01916 Deoxyhypusine synthase 0.0001 PF00676 Dehydrogenase E1 component 0.0001 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0001 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains SUB556 N=C-C=C 0.0771 PF03073 TspO/MBR family 0.0568 PF00069 Protein kinase domain 0.0526 PF00186 Dihydrofolate reductase 0.0487 PF01048 Phosphorylase superfamily 0.0363 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0273 PF00478 IMP dehydrogenase / GMP reductase domain 0.0236 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0199 PF03953 Tubulin C-terminal domain 0.0199 PF00091 Tubulin/FtsZ family, GTPase domain 0.0193 PF00571 CBS domain 0.0172 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0172 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0146 PF00962 Adenosine/AMP deaminase 0.0130 PF01126 Heme oxygenase 0.0117 PF01590 GAF domain 0.0075 PF00156 Phosphoribosyl transferase domain 0.0075 PF08240 Alcohol dehydrogenase GroES-like domain 0.0073 PF00017 SH2 domain 0.0067 PF00042 Globin 0.0061 PF00107 Zinc-binding dehydrogenase 0.0056 PF00018 SH3 domain 0.0052 PF00858 Amiloride-sensitive sodium channel 0.0049 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0044 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0033 PF00343 Carbohydrate phosphorylase 0.0033 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0033 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0029 PF02267 ADP-ribosyl cyclase 0.0023 PF00106 short chain dehydrogenase 0.0018 PF08919 F-actin binding 0.0010 PF00005 ABC transporter 0.0004 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0002 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0002 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0002 PF02770 Acyl-CoA dehydrogenase, middle domain SUB624 O=C-C:C-C 0.0764 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0764 PF00204 DNA gyrase B 0.0764 PF08070 DTHCT (NUC029), region 0.0669 PF03098 Animal haem peroxidase 0.0379 PF00191 Annexin 0.0356 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0334 PF02155 Glucocorticoid receptor 0.0286 PF00273 Serum albumin family 0.0280 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0278 PF00105 Zinc finger, C4 type (two domains), 0.0246 PF00102 Protein-tyrosine phosphatase 0.0192 PF07884 Vitamin K epoxide reductase family 0.0129 PF01735 Lysophospholipase catalytic domain 0.0124 PF00005 ABC transporter 0.0111 PF06512 Sodium ion transport-associated 0.0105 PF02161 Progesterone receptor 0.0097 PF00576 HIUase/Transthyretin family 0.0095 PF02525 Flavodoxin-like fold 0.0089 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0088 PF00079 Serpin (serine protease inhibitor), 0.0086 PF00664 ABC transporter transmembrane region 0.0085 PF01268 Formate--tetrahydrofolate ligase 0.0084 PF00464 Serine hydroxymethyltransferase 0.0083 PF09396 Thrombin light chain 0.0082 PF02166 Androgen receptor 0.0077 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0077 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0067 PF00051 Kringle domain 0.0066 PF00089 Trypsin 0.0060 PF00554 Rel homology domain (RHD), 0.0056 PF08063 PADR1 (NUC008), domain 0.0056 PF05406 WGR domain 0.0056 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0056 PF00533 BRCA1 C Terminus (BRCT), domain 0.0056 PF01061 ABC-2 type transporter 0.0056 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0049 PF08403 Amino acid permease N-terminal 0.0048 PF00551 Formyl transferase 0.0046 PF00017 SH2 domain 0.0046 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0043 PF11825 Protein of unknown function (DUF3345), 0.0038 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0038 PF01571 Aminomethyltransferase folate-binding domain 0.0029 PF00018 SH3 domain 0.0025 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0025 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0025 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0022 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0022 PF02219 Methylenetetrahydrofolate reductase 0.0021 PF00531 Death domain 0.0016 PF00229 TNF(Tumour Necrosis Factor), family 0.0015 PF00183 Hsp90 protein 0.0011 PF03953 Tubulin C-terminal domain 0.0011 PF00091 Tubulin/FtsZ family, GTPase domain 0.0010 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0008 PF01467 Cytidylyltransferase 0.0007 PF00343 Carbohydrate phosphorylase 0.0006 PF00405 Transferrin 0.0006 PF02911 Formyl transferase, C-terminal domain 0.0006 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0006 PF03024 Folate receptor family 0.0004 PF00754 F5/8 type C domain 0.0004 PF00248 Aldo/keto reductase family 0.0004 PF08919 F-actin binding 0.0003 PF03957 Jun-like transcription factor 0.0003 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0003 PF01180 Dihydroorotate dehydrogenase 0.0003 PF01187 Macrophage migration inhibitory factor (MIF), 0.0003 PF00305 Lipoxygenase 0.0003 PF03171 2OG-Fe(II), oxygenase superfamily 0.0003 PF00291 Pyridoxal-phosphate dependent enzyme 0.0002 PF00656 Caspase domain 0.0002 PF00377 Prion/Doppel alpha-helical domain 0.0002 PF00168 C2 domain 0.0002 PF02260 FATC domain 0.0002 PF00271 Helicase conserved C-terminal domain 0.0002 PF00085 Thioredoxin 0.0002 PF08659 KR domain 0.0002 PF00266 Aminotransferase class-V 0.0002 PF02259 FAT domain 0.0002 PF08771 Rapamycin binding domain 0.0002 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0002 PF00108 Thiolase, N-terminal domain 0.0002 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0002 PF00390 Malic enzyme, N-terminal domain 0.0002 PF00698 Acyl transferase domain 0.0002 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0002 PF02803 Thiolase, C-terminal domain 0.0002 PF00340 Interleukin-1 / 18 0.0002 PF00341 Platelet-derived growth factor (PDGF), 0.0002 PF00155 Aminotransferase class I and II 0.0002 PF00493 MCM2/3/5 family 0.0002 PF01347 Lipoprotein amino terminal region 0.0002 PF00989 PAS fold 0.0002 PF01202 Shikimate kinase 0.0002 PF02798 Glutathione S-transferase, N-terminal domain 0.0002 PF02394 Interleukin-1 propeptide 0.0002 PF00975 Thioesterase domain 0.0002 PF01477 PLAT/LH2 domain 0.0002 PF03949 Malic enzyme, NAD binding domain 0.0002 PF00043 Glutathione S-transferase, C-terminal domain 0.0002 PF00170 bZIP transcription factor 0.0002 PF00040 Fibronectin type II domain 0.0002 PF00071 Ras family 0.0002 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 0.0002 PF01023 S-100/ICaBP type calcium binding domain 0.0001 PF03473 MOSC domain 0.0001 PF03476 MOSC N-terminal beta barrel domain 0.0001 PF02180 Bcl-2 homology region 4 0.0001 PF03034 Phosphatidyl serine synthase 0.0001 PF00176 SNF2 family N-terminal domain 0.0001 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0001 PF00186 Dihydrofolate reductase 0.0001 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0001 PF03623 Focal adhesion targeting region 0.0001 PF01168 Alanine racemase, N-terminal domain 0.0001 PF08742 C8 domain 0.0001 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0001 PF00027 Cyclic nucleotide-binding domain 0.0001 PF00294 pfkB family carbohydrate kinase 0.0001 PF02928 C5HC2 zinc finger 0.0001 PF02793 Hormone receptor domain 0.0001 PF02025 Interleukin 5 0.0001 PF02059 Interleukin-3 0.0001 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 0.0001 PF07647 SAM domain (Sterile alpha motif), 0.0001 PF00058 Low-density lipoprotein receptor repeat class B 0.0001 PF00057 Low-density lipoprotein receptor domain class A 0.0001 PF11404 Potassium voltage-gated channel 0.0001 PF00781 Diacylglycerol kinase catalytic domain 0.0001 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0001 PF01212 Beta-eliminating lyase 0.0001 PF08429 PLU-1-like protein 0.0001 PF06448 Domain of Unknown Function (DUF1081), 0.0001 PF03062 MBOAT family 0.0001 PF02824 TGS domain 0.0001 PF01068 ATP dependent DNA ligase domain 0.0001 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0001 PF02347 Glycine cleavage system P-protein 0.0001 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0001 PF04679 ATP dependent DNA ligase C terminal region 0.0001 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.0001 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0001 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0001 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0001 PF01596 O-methyltransferase 0.0001 PF01833 IPT/TIG domain 0.0001 PF00342 Phosphoglucose isomerase 0.0001 PF00628 PHD-finger 0.0001 PF09193 Cholecystokinin A receptor, N-terminal 0.0001 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0001 PF00246 Zinc carboxypeptidase 0.0001 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0001 PF02898 Nitric oxide synthase, oxygenase domain 0.0001 PF01403 Sema domain 0.0001 PF00094 von Willebrand factor type D domain 0.0001 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0001 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0001 PF00550 Phosphopantetheine attachment site 0.0001 PF01731 Arylesterase 0.0001 PF00717 Peptidase S24-like 0.0001 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 0.0001 PF07690 Major Facilitator Superfamily 0.0001 PF00969 Class II histocompatibility antigen, beta domain 0.0001 PF01425 Amidase 0.0001 PF01429 Methyl-CpG binding domain 0.0001 PF01437 Plexin repeat 0.0001 PF12491 Apolipoprotein B100 C terminal 0.0001 PF01130 CD36 family 0.0001 PF03351 DOMON domain 0.0001 PF02403 Seryl-tRNA synthetase N-terminal domain 0.0001 PF00860 Permease family 0.0001 PF01388 ARID/BRIGHT DNA binding domain 0.0001 PF02375 jmjN domain 0.0001 PF02373 JmjC domain 0.0001 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0001 PF00270 DEAD/DEAH box helicase 0.0001 PF00002 7 transmembrane receptor (Secretin family), 0.0001 PF00274 Fructose-bisphosphate aldolase class-I 0.0001 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0001 PF03360 Glycosyltransferase family 43 0.0001 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.0001 PF02666 Phosphatidylserine decarboxylase 0.0001 PF01391 Collagen triple helix repeat (20 copies), 0.0001 PF00755 Choline/Carnitine o-acyltransferase 0.0001 PF00609 Diacylglycerol kinase accessory domain 0.0001 PF01753 MYND finger 0.0001 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 0.0001 PF00654 Voltage gated chloride channel SUB682 O-C-C-C-C-O 0.0745 PF02806 Alpha amylase, C-terminal all-beta domain 0.0571 PF00128 Alpha amylase, catalytic domain 0.0557 PF03414 Glycosyltransferase family 6 0.0333 PF08070 DTHCT (NUC029), region 0.0333 PF00204 DNA gyrase B 0.0333 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0323 PF00079 Serpin (serine protease inhibitor), 0.0310 PF02155 Glucocorticoid receptor 0.0284 PF00191 Annexin 0.0247 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0227 PF00059 Lectin C-type domain 0.0216 PF00167 Fibroblast growth factor 0.0184 PF00084 Sushi domain (SCR repeat), 0.0166 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0164 PF07654 Immunoglobulin C1-set domain 0.0154 PF01735 Lysophospholipase catalytic domain 0.0132 PF01048 Phosphorylase superfamily 0.0132 PF00143 Interferon alpha/beta domain 0.0114 PF00091 Tubulin/FtsZ family, GTPase domain 0.0114 PF03953 Tubulin C-terminal domain 0.0102 PF08702 Fibrinogen alpha/beta chain family 0.0102 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0101 PF00349 Hexokinase 0.0101 PF03727 Hexokinase 0.0101 PF02223 Thymidylate kinase 0.0085 PF02267 ADP-ribosyl cyclase 0.0079 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0078 PF12160 Fibrinogen alpha C domain 0.0075 PF00303 Thymidylate synthase 0.0073 PF00088 Trefoil (P-type), domain 0.0073 PF01055 Glycosyl hydrolases family 31 0.0071 PF01370 NAD dependent epimerase/dehydratase family 0.0067 PF07686 Immunoglobulin V-set domain 0.0066 PF00293 NUDIX domain 0.0066 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0065 PF00106 short chain dehydrogenase 0.0064 PF02065 Melibiase 0.0062 PF00337 Galactoside-binding lectin 0.0061 PF00328 Histidine acid phosphatase 0.0055 PF00689 Cation transporting ATPase, C-terminus 0.0055 PF00690 Cation transporter/ATPase, N-terminus 0.0054 PF07645 Calcium-binding EGF domain 0.0049 PF01068 ATP dependent DNA ligase domain 0.0049 PF04679 ATP dependent DNA ligase C terminal region 0.0047 PF00089 Trypsin 0.0046 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0044 PF03770 Inositol polyphosphate kinase 0.0043 PF00122 E1-E2 ATPase 0.0043 PF01532 Glycosyl hydrolase family 47 0.0043 PF00041 Fibronectin type III domain 0.0039 PF00005 ABC transporter 0.0037 PF01607 Chitin binding Peritrophin-A domain 0.0037 PF00704 Glycosyl hydrolases family 18 0.0036 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0036 PF00431 CUB domain 0.0034 PF01467 Cytidylyltransferase 0.0030 PF00702 haloacid dehalogenase-like hydrolase 0.0028 PF00664 ABC transporter transmembrane region 0.0027 PF00171 Aldehyde dehydrogenase family 0.0025 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0025 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0024 PF00024 PAN domain 0.0023 PF08035 Opioids neuropeptide 0.0023 PF08384 Pro-opiomelanocortin, N-terminal region 0.0023 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.0023 PF00976 Corticotropin ACTH domain 0.0022 PF00403 Heavy-metal-associated domain 0.0022 PF00031 Cystatin domain 0.0022 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0022 PF04711 Apolipoprotein A-II (ApoA-II), 0.0022 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0020 PF00058 Low-density lipoprotein receptor repeat class B 0.0019 PF00057 Low-density lipoprotein receptor domain class A 0.0019 PF07648 Kazal-type serine protease inhibitor domain 0.0017 PF00884 Sulfatase 0.0016 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0016 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0016 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0015 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0015 PF03171 2OG-Fe(II), oxygenase superfamily 0.0015 PF02055 O-Glycosyl hydrolase family 30 0.0013 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0013 PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), 0.0013 PF00200 Disintegrin 0.0013 PF00093 von Willebrand factor type C domain 0.0013 PF00090 Thrombospondin type 1 domain 0.0013 PF08516 ADAM cysteine-rich 0.0013 PF00703 domain 0.0013 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0013 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 0.0013 PF00021 u-PAR/Ly-6 domain 0.0013 PF05735 Thrombospondin C-terminal region 0.0013 PF00236 Glycoprotein hormone 0.0013 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0013 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0013 PF01869 BadF/BadG/BcrA/BcrD ATPase family 0.0013 PF08240 Alcohol dehydrogenase GroES-like domain 0.0013 PF01562 Reprolysin family propeptide 0.0013 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0013 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0013 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0010 PF00714 Interferon gamma 0.0010 PF00183 Hsp90 protein 0.0009 PF10420 Cytokine interleukin-12p40 C-terminus 0.0009 PF03781 Formylglycine-generating sulfatase enzyme 0.0009 PF00248 Aldo/keto reductase family 0.0008 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0007 PF01687 Riboflavin kinase 0.0007 PF00071 Ras family 0.0007 PF00107 Zinc-binding dehydrogenase 0.0005 PF07884 Vitamin K epoxide reductase family 0.0005 PF01842 ACT domain 0.0005 PF08718 Glycolipid transfer protein (GLTP), 0.0004 PF01122 Eukaryotic cobalamin-binding protein 0.0004 PF01230 HIT domain 0.0004 PF00571 CBS domain 0.0003 PF03360 Glycosyltransferase family 43 0.0001 PF00176 SNF2 family N-terminal domain SUB642 O-C-C-C=C 0.0669 PF00001 7 transmembrane receptor (rhodopsin family), 0.0465 PF02159 Oestrogen receptor 0.0399 PF00105 Zinc finger, C4 type (two domains), 0.0395 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0300 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0192 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0192 PF00204 DNA gyrase B 0.0192 PF08070 DTHCT (NUC029), region 0.0182 PF00209 Sodium:neurotransmitter symporter family 0.0126 PF03098 Animal haem peroxidase 0.0087 PF00989 PAS fold 0.0077 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0070 PF00027 Cyclic nucleotide-binding domain 0.0068 PF00005 ABC transporter 0.0061 PF00091 Tubulin/FtsZ family, GTPase domain 0.0061 PF03953 Tubulin C-terminal domain 0.0055 PF00664 ABC transporter transmembrane region 0.0051 PF09396 Thrombin light chain 0.0047 PF12497 Estrogen receptor beta 0.0042 PF00067 Cytochrome P450 0.0040 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0036 PF00576 HIUase/Transthyretin family 0.0029 PF08035 Opioids neuropeptide 0.0029 PF00976 Corticotropin ACTH domain 0.0029 PF08384 Pro-opiomelanocortin, N-terminal region 0.0028 PF00102 Protein-tyrosine phosphatase 0.0028 PF11825 Protein of unknown function (DUF3345), 0.0027 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0017 PF02161 Progesterone receptor 0.0017 PF00273 Serum albumin family 0.0015 PF01593 Flavin containing amine oxidoreductase 0.0015 PF00643 B-box zinc finger 0.0014 PF01596 O-methyltransferase 0.0013 PF03073 TspO/MBR family 0.0010 PF00305 Lipoxygenase 0.0010 PF03062 MBOAT family 0.0010 PF02394 Interleukin-1 propeptide 0.0010 PF00340 Interleukin-1 / 18 0.0010 PF01477 PLAT/LH2 domain 0.0008 PF02166 Androgen receptor 0.0008 PF08983 Domain of unknown function (DUF1856), 0.0006 PF04622 ERG2 and Sigma1 receptor like protein 0.0005 PF00183 Hsp90 protein 0.0005 PF00918 Gastrin/cholecystokinin family 0.0005 PF00656 Caspase domain 0.0005 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0005 PF01160 Vertebrate endogenous opioids neuropeptide 0.0004 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0003 PF02460 Patched family 0.0003 PF03765 CRAL/TRIO, N-terminus 0.0003 PF08377 MAP2/Tau projection domain 0.0003 PF00135 Carboxylesterase 0.0003 PF00884 Sulfatase 0.0003 PF01588 Putative tRNA binding domain 0.0003 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0003 PF00650 CRAL/TRIO domain 0.0003 PF02180 Bcl-2 homology region 4 0.0003 PF00377 Prion/Doppel alpha-helical domain 0.0003 PF01180 Dihydroorotate dehydrogenase 0.0003 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0003 PF00625 Guanylate kinase 0.0003 PF06327 Domain of Unknown Function (DUF1053), 0.0003 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0003 PF08441 Integrin alpha 0.0002 PF00357 Integrin alpha cytoplasmic region 0.0002 PF00229 TNF(Tumour Necrosis Factor), family 0.0002 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0002 PF07885 Ion channel 0.0001 PF02173 pKID domain 0.0001 PF01733 Nucleoside transporter 0.0001 PF00170 bZIP transcription factor 0.0001 PF08742 C8 domain 0.0001 PF00341 Platelet-derived growth factor (PDGF), 0.0001 PF00002 7 transmembrane receptor (Secretin family), 0.0001 PF00094 von Willebrand factor type D domain 0.0001 PF00757 Furin-like cysteine rich region 0.0001 PF02201 SWIB/MDM2 domain 0.0001 PF00620 RhoGAP domain 0.0001 PF00641 Zn-finger in Ran binding protein and others 0.0001 PF01347 Lipoprotein amino terminal region 0.0001 PF02793 Hormone receptor domain 0.0001 PF02025 Interleukin 5 0.0001 PF01030 Receptor L domain 0.0001 PF09193 Cholecystokinin A receptor, N-terminal 0.0001 PF00266 Aminotransferase class-V 0.0001 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0001 PF00068 Phospholipase A2 0.0001 PF08763 Voltage gated calcium channel IQ domain SUB26 >= 4 F 0.0668 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0666 PF00146 NADH dehydrogenase 0.0440 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0440 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0412 PF02254 TrkA-N domain 0.0412 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0327 PF00689 Cation transporting ATPase, C-terminus 0.0327 PF00690 Cation transporter/ATPase, N-terminus 0.0298 PF02888 Calmodulin binding domain 0.0298 PF03530 Calcium-activated SK potassium channel 0.0297 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0297 PF00631 GGL domain 0.0289 PF00122 E1-E2 ATPase 0.0257 PF00702 haloacid dehalogenase-like hydrolase 0.0243 PF00191 Annexin 0.0243 PF02214 K+ channel tetramerisation domain 0.0237 PF00194 Eukaryotic-type carbonic anhydrase 0.0204 PF01007 Inward rectifier potassium channel 0.0197 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0141 PF00273 Serum albumin family 0.0141 PF00520 Ion transport protein 0.0139 PF12497 Estrogen receptor beta 0.0132 PF07885 Ion channel 0.0116 PF00060 Ligand-gated ion channel 0.0109 PF08403 Amino acid permease N-terminal 0.0102 PF02155 Glucocorticoid receptor 0.0092 PF02159 Oestrogen receptor 0.0083 PF01094 Receptor family ligand binding region 0.0059 PF08377 MAP2/Tau projection domain 0.0059 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0057 PF00079 Serpin (serine protease inhibitor), 0.0055 PF06464 DMAP1-binding Domain 0.0055 PF02008 CXXC zinc finger domain 0.0055 PF01426 BAH domain 0.0054 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0041 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0035 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0034 PF02984 Cyclin, C-terminal domain 0.0034 PF07970 Endoplasmic reticulum vesicle transporter 0.0034 PF00134 Cyclin, N-terminal domain 0.0034 PF00489 Interleukin-6/G-CSF/MGF family 0.0034 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0034 PF00324 Amino acid permease 0.0034 PF12126 Protein of unknown function (DUF3583), 0.0033 PF03957 Jun-like transcription factor 0.0029 PF00145 C-5 cytosine-specific DNA methylase 0.0023 PF00170 bZIP transcription factor 0.0023 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0022 PF00462 Glutaredoxin 0.0020 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0019 PF00643 B-box zinc finger 0.0018 PF00069 Protein kinase domain 0.0016 PF00576 HIUase/Transthyretin family 0.0013 PF00433 Protein kinase C terminal domain 0.0012 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0012 PF00102 Protein-tyrosine phosphatase 0.0009 PF00169 PH domain 0.0009 PF00664 ABC transporter transmembrane region 0.0009 PF01735 Lysophospholipase catalytic domain 0.0008 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0008 PF00105 Zinc finger, C4 type (two domains), 0.0007 PF03073 TspO/MBR family 0.0007 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0007 PF00005 ABC transporter 0.0007 PF08070 DTHCT (NUC029), region 0.0007 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0007 PF00204 DNA gyrase B 0.0006 PF02166 Androgen receptor 0.0005 PF01161 Phosphatidylethanolamine-binding protein 0.0004 PF00459 Inositol monophosphatase family 0.0004 PF00405 Transferrin 0.0003 PF00581 Rhodanese-like domain 0.0003 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0003 PF06617 M-phase inducer phosphatase 0.0003 PF03160 Calx-beta domain 0.0002 PF00303 Thymidylate synthase 0.0002 PF03454 MoeA C-terminal region (domain IV), 0.0002 PF03453 MoeA N-terminal region (domain I and II), 0.0002 PF00994 Probable molybdopterin binding domain 0.0002 PF00625 Guanylate kinase 0.0002 PF02828 L27 domain 0.0002 PF00514 Armadillo/beta-catenin-like repeat 0.0002 PF00822 PMP-22/EMP/MP20/Claudin family 0.0002 PF07965 Integrin beta tail domain 0.0002 PF01369 Sec7 domain 0.0002 PF00362 Integrin, beta chain 0.0001 PF00211 Adenylate and Guanylate cyclase catalytic domain 0.0001 PF07653 Variant SH3 domain 0.0001 PF00041 Fibronectin type III domain 0.0001 PF02867 Ribonucleotide reductase, barrel domain 0.0001 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0001 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0001 PF02743 Cache domain 0.0001 PF00390 Malic enzyme, N-terminal domain 0.0001 PF00854 POT family 0.0001 PF08763 Voltage gated calcium channel IQ domain 0.0001 PF00317 Ribonucleotide reductase, all-alpha domain 0.0001 PF08240 Alcohol dehydrogenase GroES-like domain 0.0001 PF00248 Aldo/keto reductase family 0.0001 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0001 PF08399 VWA N-terminal 0.0001 PF03477 ATP cone domain 0.0001 PF00107 Zinc-binding dehydrogenase 0.0001 PF03949 Malic enzyme, NAD binding domain SUB647 O=C-N-C-[#1] 0.0652 PF01401 Angiotensin-converting enzyme 0.0414 PF03073 TspO/MBR family 0.0406 PF09396 Thrombin light chain 0.0344 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0275 PF00045 Hemopexin 0.0275 PF01471 Putative peptidoglycan binding domain 0.0259 PF00102 Protein-tyrosine phosphatase 0.0250 PF02798 Glutathione S-transferase, N-terminal domain 0.0243 PF00043 Glutathione S-transferase, C-terminal domain 0.0242 PF00413 Matrixin 0.0191 PF01431 Peptidase family M13 0.0191 PF05649 Peptidase family M13 0.0155 PF08983 Domain of unknown function (DUF1856), 0.0154 PF01048 Phosphorylase superfamily 0.0151 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0116 PF01590 GAF domain 0.0110 PF00303 Thymidylate synthase 0.0087 PF00255 Glutathione peroxidase 0.0069 PF00051 Kringle domain 0.0061 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0059 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0057 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0057 PF06512 Sodium ion transport-associated 0.0057 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0052 PF01268 Formate--tetrahydrofolate ligase 0.0049 PF00854 POT family 0.0044 PF00551 Formyl transferase 0.0034 PF01808 AICARFT/IMPCHase bienzyme 0.0021 PF00868 Transglutaminase family 0.0021 PF01841 Transglutaminase-like superfamily 0.0021 PF00927 Transglutaminase family, C-terminal ig like domain 0.0019 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0019 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0019 PF00026 Eukaryotic aspartyl protease 0.0019 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0018 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0015 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0015 PF01571 Aminomethyltransferase folate-binding domain 0.0014 PF07966 A1 Propeptide 0.0008 PF00089 Trypsin 0.0004 PF02769 AIR synthase related protein, C-terminal domain 0.0004 PF00586 AIR synthase related protein, N-terminal domain 0.0001 PF02142 MGS-like domain SUB638 O-C-C-C-C 0.0652 PF02159 Oestrogen receptor 0.0611 PF00105 Zinc finger, C4 type (two domains), 0.0601 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0478 PF08070 DTHCT (NUC029), region 0.0478 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0478 PF00204 DNA gyrase B 0.0432 PF00191 Annexin 0.0418 PF02155 Glucocorticoid receptor 0.0367 PF03098 Animal haem peroxidase 0.0320 PF00273 Serum albumin family 0.0250 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0227 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0221 PF00079 Serpin (serine protease inhibitor), 0.0211 PF00001 7 transmembrane receptor (rhodopsin family), 0.0184 PF00091 Tubulin/FtsZ family, GTPase domain 0.0184 PF03953 Tubulin C-terminal domain 0.0182 PF01401 Angiotensin-converting enzyme 0.0152 PF00576 HIUase/Transthyretin family 0.0151 PF02161 Progesterone receptor 0.0149 PF01735 Lysophospholipase catalytic domain 0.0133 PF00102 Protein-tyrosine phosphatase 0.0115 PF02166 Androgen receptor 0.0093 PF01063 Aminotransferase class IV 0.0083 PF00005 ABC transporter 0.0080 PF00989 PAS fold 0.0079 PF08035 Opioids neuropeptide 0.0079 PF12497 Estrogen receptor beta 0.0079 PF08384 Pro-opiomelanocortin, N-terminal region 0.0079 PF00976 Corticotropin ACTH domain 0.0074 PF00664 ABC transporter transmembrane region 0.0070 PF00155 Aminotransferase class I and II 0.0067 PF00027 Cyclic nucleotide-binding domain 0.0066 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0065 PF02806 Alpha amylase, C-terminal all-beta domain 0.0049 PF00168 C2 domain 0.0049 PF01842 ACT domain 0.0047 PF03414 Glycosyltransferase family 6 0.0045 PF00557 Metallopeptidase family M24 0.0043 PF00202 Aminotransferase class-III 0.0042 PF00303 Thymidylate synthase 0.0035 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0034 PF01477 PLAT/LH2 domain 0.0031 PF00822 PMP-22/EMP/MP20/Claudin family 0.0028 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0026 PF00128 Alpha amylase, catalytic domain 0.0026 PF00067 Cytochrome P450 0.0021 PF01268 Formate--tetrahydrofolate ligase 0.0019 PF07966 A1 Propeptide 0.0019 PF00464 Serine hydroxymethyltransferase 0.0018 PF11825 Protein of unknown function (DUF3345), 0.0017 PF01126 Heme oxygenase 0.0016 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0016 PF01431 Peptidase family M13 0.0016 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0016 PF05649 Peptidase family M13 0.0015 PF00026 Eukaryotic aspartyl protease 0.0013 PF00305 Lipoxygenase 0.0012 PF00248 Aldo/keto reductase family 0.0011 PF07648 Kazal-type serine protease inhibitor domain 0.0009 PF00151 Lipase 0.0008 PF00183 Hsp90 protein 0.0007 PF00175 Oxidoreductase NAD-binding domain 0.0007 PF00291 Pyridoxal-phosphate dependent enzyme 0.0006 PF00340 Interleukin-1 / 18 0.0006 PF01061 ABC-2 type transporter 0.0006 PF02394 Interleukin-1 propeptide 0.0005 PF00059 Lectin C-type domain 0.0005 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0005 PF00733 Asparagine synthase 0.0005 PF02898 Nitric oxide synthase, oxygenase domain 0.0005 PF08763 Voltage gated calcium channel IQ domain 0.0004 PF00071 Ras family 0.0004 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0004 PF00571 CBS domain 0.0004 PF08441 Integrin alpha 0.0004 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0003 PF00667 FAD binding domain 0.0003 PF00258 Flavodoxin 0.0003 PF03171 2OG-Fe(II), oxygenase superfamily 0.0003 PF00229 TNF(Tumour Necrosis Factor), family 0.0003 PF07706 Aminotransferase ubiquitination site 0.0003 PF00643 B-box zinc finger 0.0003 PF00266 Aminotransferase class-V 0.0002 PF02798 Glutathione S-transferase, N-terminal domain 0.0002 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0001 PF02259 FAT domain 0.0001 PF03765 CRAL/TRIO, N-terminus 0.0001 PF02260 FATC domain 0.0001 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0001 PF08771 Rapamycin binding domain 0.0001 PF00650 CRAL/TRIO domain 0.0001 PF00043 Glutathione S-transferase, C-terminal domain 0.0001 PF02180 Bcl-2 homology region 4 SUB702 O-C-C-C-C-C(O)-C 0.0651 PF02806 Alpha amylase, C-terminal all-beta domain 0.0519 PF00128 Alpha amylase, catalytic domain 0.0507 PF03414 Glycosyltransferase family 6 0.0425 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0425 PF00204 DNA gyrase B 0.0425 PF08070 DTHCT (NUC029), region 0.0227 PF00079 Serpin (serine protease inhibitor), 0.0221 PF00059 Lectin C-type domain 0.0212 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0208 PF00167 Fibroblast growth factor 0.0198 PF00084 Sushi domain (SCR repeat), 0.0178 PF07654 Immunoglobulin C1-set domain 0.0159 PF00143 Interferon alpha/beta domain 0.0130 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0130 PF08702 Fibrinogen alpha/beta chain family 0.0115 PF02155 Glucocorticoid receptor 0.0099 PF12160 Fibrinogen alpha C domain 0.0096 PF03727 Hexokinase 0.0096 PF00349 Hexokinase 0.0092 PF00088 Trefoil (P-type), domain 0.0092 PF01055 Glycosyl hydrolases family 31 0.0091 PF01735 Lysophospholipase catalytic domain 0.0090 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0085 PF07686 Immunoglobulin V-set domain 0.0085 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0084 PF00293 NUDIX domain 0.0082 PF02065 Melibiase 0.0079 PF00337 Galactoside-binding lectin 0.0078 PF00328 Histidine acid phosphatase 0.0073 PF02267 ADP-ribosyl cyclase 0.0070 PF00690 Cation transporter/ATPase, N-terminus 0.0070 PF00689 Cation transporting ATPase, C-terminus 0.0069 PF07645 Calcium-binding EGF domain 0.0062 PF01068 ATP dependent DNA ligase domain 0.0062 PF04679 ATP dependent DNA ligase C terminal region 0.0061 PF01370 NAD dependent epimerase/dehydratase family 0.0060 PF00089 Trypsin 0.0055 PF00122 E1-E2 ATPase 0.0054 PF00041 Fibronectin type III domain 0.0046 PF00431 CUB domain 0.0046 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0039 PF00702 haloacid dehalogenase-like hydrolase 0.0031 PF00024 PAN domain 0.0030 PF01532 Glycosyl hydrolase family 47 0.0028 PF00031 Cystatin domain 0.0028 PF04711 Apolipoprotein A-II (ApoA-II), 0.0028 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0028 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0028 PF00403 Heavy-metal-associated domain 0.0025 PF07648 Kazal-type serine protease inhibitor domain 0.0025 PF00058 Low-density lipoprotein receptor repeat class B 0.0025 PF00057 Low-density lipoprotein receptor domain class A 0.0022 PF00884 Sulfatase 0.0020 PF00191 Annexin 0.0019 PF03171 2OG-Fe(II), oxygenase superfamily 0.0019 PF02055 O-Glycosyl hydrolase family 30 0.0019 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0016 PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), 0.0016 PF00703 domain 0.0016 PF00093 von Willebrand factor type C domain 0.0016 PF00090 Thrombospondin type 1 domain 0.0016 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0016 PF01562 Reprolysin family propeptide 0.0016 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0016 PF01869 BadF/BadG/BcrA/BcrD ATPase family 0.0016 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0016 PF00021 u-PAR/Ly-6 domain 0.0016 PF00236 Glycoprotein hormone 0.0016 PF05735 Thrombospondin C-terminal region 0.0016 PF08516 ADAM cysteine-rich 0.0016 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 0.0016 PF00200 Disintegrin 0.0016 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0016 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0016 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0016 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0013 PF00183 Hsp90 protein 0.0012 PF00714 Interferon gamma 0.0012 PF03781 Formylglycine-generating sulfatase enzyme 0.0011 PF10420 Cytokine interleukin-12p40 C-terminus 0.0010 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0007 PF07884 Vitamin K epoxide reductase family 0.0006 PF08718 Glycolipid transfer protein (GLTP), 0.0001 PF00176 SNF2 family N-terminal domain SUB16 >= 2 N 0.0637 PF00194 Eukaryotic-type carbonic anhydrase 0.0176 PF01048 Phosphorylase superfamily 0.0162 PF00186 Dihydrofolate reductase 0.0155 PF00303 Thymidylate synthase 0.0136 PF02223 Thymidylate kinase 0.0122 PF00324 Amino acid permease 0.0107 PF08403 Amino acid permease N-terminal 0.0106 PF00478 IMP dehydrogenase / GMP reductase domain 0.0101 PF00107 Zinc-binding dehydrogenase 0.0097 PF00069 Protein kinase domain 0.0096 PF08240 Alcohol dehydrogenase GroES-like domain 0.0095 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0090 PF02806 Alpha amylase, C-terminal all-beta domain 0.0088 PF01842 ACT domain 0.0086 PF02898 Nitric oxide synthase, oxygenase domain 0.0075 PF00128 Alpha amylase, catalytic domain 0.0072 PF02254 TrkA-N domain 0.0072 PF00310 Glutamine amidotransferases class-II 0.0072 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0067 PF06512 Sodium ion transport-associated 0.0065 PF02798 Glutathione S-transferase, N-terminal domain 0.0064 PF00043 Glutathione S-transferase, C-terminal domain 0.0064 PF00156 Phosphoribosyl transferase domain 0.0063 PF00175 Oxidoreductase NAD-binding domain 0.0059 PF00258 Flavodoxin 0.0059 PF00667 FAD binding domain 0.0059 PF00962 Adenosine/AMP deaminase 0.0056 PF01426 BAH domain 0.0056 PF02008 CXXC zinc finger domain 0.0056 PF06464 DMAP1-binding Domain 0.0052 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0052 PF00733 Asparagine synthase 0.0047 PF00571 CBS domain 0.0046 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0039 PF00868 Transglutaminase family 0.0039 PF00927 Transglutaminase family, C-terminal ig like domain 0.0039 PF01841 Transglutaminase-like superfamily 0.0038 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0037 PF03477 ATP cone domain 0.0037 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0037 PF00317 Ribonucleotide reductase, all-alpha domain 0.0037 PF02867 Ribonucleotide reductase, barrel domain 0.0036 PF09396 Thrombin light chain 0.0035 PF00764 Arginosuccinate synthase 0.0035 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0035 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0034 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0032 PF00958 GMP synthase C terminal domain 0.0031 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0031 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0031 PF00145 C-5 cytosine-specific DNA methylase 0.0030 PF00117 Glutamine amidotransferase class-I 0.0029 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0029 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0028 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0028 PF03199 Eukaryotic glutathione synthase 0.0028 PF01268 Formate--tetrahydrofolate ligase 0.0027 PF01063 Aminotransferase class IV 0.0023 PF00858 Amiloride-sensitive sodium channel 0.0020 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0020 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0019 PF01401 Angiotensin-converting enzyme 0.0017 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0017 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0016 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0016 PF02142 MGS-like domain 0.0015 PF01370 NAD dependent epimerase/dehydratase family 0.0013 PF01490 Transmembrane amino acid transporter protein 0.0013 PF00051 Kringle domain 0.0012 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0011 PF01467 Cytidylyltransferase 0.0010 PF02267 ADP-ribosyl cyclase 0.0008 PF02727 Copper amine oxidase, N2 domain 0.0008 PF02728 Copper amine oxidase, N3 domain 0.0008 PF01179 Copper amine oxidase, enzyme domain 0.0008 PF01536 Adenosylmethionine decarboxylase 0.0007 PF01916 Deoxyhypusine synthase 0.0007 PF00255 Glutathione peroxidase 0.0006 PF08919 F-actin binding 0.0006 PF01808 AICARFT/IMPCHase bienzyme 0.0003 PF00375 Sodium:dicarboxylate symporter family 0.0003 PF00183 Hsp90 protein 0.0003 PF00018 SH3 domain 0.0003 PF00171 Aldehyde dehydrogenase family 0.0002 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0002 PF00074 Pancreatic ribonuclease 0.0002 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0002 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0001 PF01590 GAF domain SUB338 C(~C)(~C)(~C)(~O) 0.0630 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0630 PF00105 Zinc finger, C4 type (two domains), 0.0615 PF02159 Oestrogen receptor 0.0532 PF00191 Annexin 0.0498 PF02155 Glucocorticoid receptor 0.0436 PF02161 Progesterone receptor 0.0329 PF02166 Androgen receptor 0.0243 PF01735 Lysophospholipase catalytic domain 0.0201 PF00079 Serpin (serine protease inhibitor), 0.0173 PF08035 Opioids neuropeptide 0.0173 PF08384 Pro-opiomelanocortin, N-terminal region 0.0173 PF00976 Corticotropin ACTH domain 0.0120 PF00091 Tubulin/FtsZ family, GTPase domain 0.0120 PF03953 Tubulin C-terminal domain 0.0096 PF00168 C2 domain 0.0085 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0084 PF11825 Protein of unknown function (DUF3345), 0.0069 PF12497 Estrogen receptor beta 0.0046 PF01429 Methyl-CpG binding domain 0.0045 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0045 PF00106 short chain dehydrogenase 0.0044 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0042 PF00643 B-box zinc finger 0.0042 PF00305 Lipoxygenase 0.0040 PF07648 Kazal-type serine protease inhibitor domain 0.0037 PF08491 Squalene epoxidase 0.0037 PF00040 Fibronectin type II domain 0.0036 PF00067 Cytochrome P450 0.0035 PF06327 Domain of Unknown Function (DUF1053), 0.0033 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0033 PF02180 Bcl-2 homology region 4 0.0030 PF01122 Eukaryotic cobalamin-binding protein 0.0029 PF00653 Inhibitor of Apoptosis domain 0.0029 PF00918 Gastrin/cholecystokinin family 0.0028 PF01477 PLAT/LH2 domain 0.0026 PF04622 ERG2 and Sigma1 receptor like protein 0.0023 PF00170 bZIP transcription factor 0.0021 PF00554 Rel homology domain (RHD), 0.0021 PF01160 Vertebrate endogenous opioids neuropeptide 0.0021 PF02173 pKID domain 0.0021 PF00212 Atrial natriuretic peptide 0.0020 PF00031 Cystatin domain 0.0019 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0019 PF00650 CRAL/TRIO domain 0.0019 PF03765 CRAL/TRIO, N-terminus 0.0018 PF01642 Methylmalonyl-CoA mutase 0.0018 PF03308 ArgK protein 0.0018 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0018 PF08377 MAP2/Tau projection domain 0.0018 PF00762 Ferrochelatase 0.0018 PF00656 Caspase domain 0.0018 PF01923 Cobalamin adenosyltransferase 0.0013 PF00377 Prion/Doppel alpha-helical domain 0.0013 PF00884 Sulfatase 0.0013 PF02310 B12 binding domain 0.0012 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0012 PF00204 DNA gyrase B 0.0012 PF08070 DTHCT (NUC029), region 0.0012 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0012 PF06907 Latexin 0.0012 PF00625 Guanylate kinase 0.0012 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0012 PF00969 Class II histocompatibility antigen, beta domain 0.0012 PF03572 Peptidase family S41 0.0011 PF00183 Hsp90 protein 0.0010 PF02394 Interleukin-1 propeptide 0.0010 PF00340 Interleukin-1 / 18 0.0010 PF00341 Platelet-derived growth factor (PDGF), 0.0010 PF00531 Death domain 0.0009 PF08763 Voltage gated calcium channel IQ domain 0.0008 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0007 PF00714 Interferon gamma 0.0006 PF00489 Interleukin-6/G-CSF/MGF family 0.0006 PF00432 Prenyltransferase and squalene oxidase repeat 0.0006 PF00357 Integrin alpha cytoplasmic region 0.0006 PF03957 Jun-like transcription factor 0.0005 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 0.0005 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0003 PF00108 Thiolase, N-terminal domain 0.0003 PF01327 Polypeptide deformylase 0.0003 PF02803 Thiolase, C-terminal domain 0.0003 PF01244 Membrane dipeptidase (Peptidase family M19), 0.0003 PF00439 Bromodomain 0.0003 PF00688 TGF-beta propeptide 0.0003 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0003 PF00890 FAD binding domain 0.0003 PF00020 TNFR/NGFR cysteine-rich region 0.0003 PF00019 Transforming growth factor beta like domain 0.0002 PF00033 Cytochrome b(N-terminal), /b6/petB 0.0002 PF00032 Cytochrome b(C-terminal), /b6/petD 0.0001 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0001 PF08441 Integrin alpha 0.0001 PF01425 Amidase SUB165 >= 4 any ring size 5 0.0618 PF01122 Eukaryotic cobalamin-binding protein 0.0457 PF02310 B12 binding domain 0.0433 PF03308 ArgK protein 0.0433 PF01642 Methylmalonyl-CoA mutase 0.0433 PF01923 Cobalamin adenosyltransferase 0.0206 PF00809 Pterin binding enzyme 0.0206 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0206 PF02607 B12 binding domain 0.0202 PF00431 CUB domain 0.0190 PF00258 Flavodoxin 0.0190 PF00667 FAD binding domain 0.0186 PF00175 Oxidoreductase NAD-binding domain 0.0132 PF07645 Calcium-binding EGF domain 0.0106 PF02574 Homocysteine S-methyltransferase 0.0058 PF02223 Thymidylate kinase 0.0054 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0048 PF08240 Alcohol dehydrogenase GroES-like domain 0.0047 PF00106 short chain dehydrogenase 0.0042 PF00107 Zinc-binding dehydrogenase 0.0042 PF00478 IMP dehydrogenase / GMP reductase domain 0.0039 PF01126 Heme oxygenase 0.0037 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0035 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0035 PF00171 Aldehyde dehydrogenase family 0.0035 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0035 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0035 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0035 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0033 PF00571 CBS domain 0.0033 PF00248 Aldo/keto reductase family 0.0033 PF02267 ADP-ribosyl cyclase 0.0030 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0030 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0026 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0024 PF01467 Cytidylyltransferase 0.0024 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0023 PF00970 Oxidoreductase FAD-binding domain 0.0021 PF01652 Eukaryotic initiation factor 4E 0.0020 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0020 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0020 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0020 PF02233 NAD(P), transhydrogenase beta subunit 0.0020 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0020 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0018 PF02036 SCP-2 sterol transfer family 0.0018 PF03770 Inositol polyphosphate kinase 0.0018 PF01575 MaoC like domain 0.0017 PF03949 Malic enzyme, NAD binding domain 0.0017 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0017 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0017 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0017 PF00390 Malic enzyme, N-terminal domain 0.0016 PF01687 Riboflavin kinase 0.0016 PF00058 Low-density lipoprotein receptor repeat class B 0.0016 PF01370 NAD dependent epimerase/dehydratase family 0.0016 PF00057 Low-density lipoprotein receptor domain class A 0.0016 PF01268 Formate--tetrahydrofolate ligase 0.0015 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0015 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0014 PF02525 Flavodoxin-like fold 0.0014 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0014 PF00676 Dehydrogenase E1 component 0.0014 PF00017 SH2 domain 0.0014 PF00069 Protein kinase domain 0.0013 PF00186 Dihydrofolate reductase 0.0013 PF00348 Polyprenyl synthetase 0.0011 PF01230 HIT domain 0.0011 PF00018 SH3 domain 0.0010 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0010 PF05347 Complex 1 protein (LYR family), 0.0010 PF00378 Enoyl-CoA hydratase/isomerase family 0.0009 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0008 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0008 PF01437 Plexin repeat 0.0008 PF01833 IPT/TIG domain 0.0008 PF02779 Transketolase, pyrimidine binding domain 0.0008 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0008 PF01403 Sema domain 0.0007 PF00498 FHA domain 0.0007 PF00501 AMP-binding enzyme 0.0007 PF08676 MutL C terminal dimerisation domain 0.0007 PF01119 DNA mismatch repair protein, C-terminal domain 0.0007 PF12423 Kinesin protein 1B 0.0007 PF12473 Kinesin protein 0.0006 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0006 PF00794 PI3-kinase family, ras-binding domain 0.0006 PF00792 Phosphoinositide 3-kinase C2 0.0005 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0005 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0005 PF00931 NB-ARC domain 0.0005 PF00400 WD domain, G-beta repeat 0.0004 PF01808 AICARFT/IMPCHase bienzyme 0.0004 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0004 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0004 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0004 PF09326 Domain of unknown function (DUF1982), 0.0004 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0004 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0004 PF08040 MNLL subunit 0.0004 PF04800 ETC complex I subunit conserved region 0.0004 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0004 PF10276 Zinc-finger domain 0.0004 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0004 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0004 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0004 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0004 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0004 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0004 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0004 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0004 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0004 PF02466 Tim17/Tim22/Tim23 family 0.0004 PF09166 Biliverdin reductase, catalytic 0.0004 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0004 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0004 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0004 PF04716 ETC complex I subunit conserved region 0.0004 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0004 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0004 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0004 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0004 PF01712 Deoxynucleoside kinase 0.0004 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0004 PF02817 e3 binding domain 0.0004 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0004 PF04116 Fatty acid hydroxylase superfamily 0.0004 PF10531 SLBB domain 0.0004 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0004 PF00384 Molybdopterin oxidoreductase 0.0004 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0004 PF00225 Kinesin motor domain 0.0004 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0004 PF06212 GRIM-19 protein 0.0004 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0004 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0004 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0003 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0003 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0002 PF00042 Globin 0.0002 PF02173 pKID domain 0.0002 PF00962 Adenosine/AMP deaminase 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0002 PF03435 Saccharopine dehydrogenase 0.0002 PF02780 Transketolase, C-terminal domain 0.0001 PF00406 Adenylate kinase 0.0001 PF01064 Activin types I and II receptor domain 0.0001 PF08515 Transforming growth factor beta type I GS-motif 0.0001 PF00170 bZIP transcription factor SUB353 C(~C)(~O) 0.0611 PF03098 Animal haem peroxidase 0.0455 PF00273 Serum albumin family 0.0351 PF01401 Angiotensin-converting enzyme 0.0329 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0329 PF00204 DNA gyrase B 0.0329 PF08070 DTHCT (NUC029), region 0.0201 PF00105 Zinc finger, C4 type (two domains), 0.0199 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0169 PF03953 Tubulin C-terminal domain 0.0169 PF00091 Tubulin/FtsZ family, GTPase domain 0.0159 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0147 PF00576 HIUase/Transthyretin family 0.0146 PF00102 Protein-tyrosine phosphatase 0.0124 PF01063 Aminotransferase class IV 0.0110 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0104 PF05649 Peptidase family M13 0.0104 PF01431 Peptidase family M13 0.0090 PF11825 Protein of unknown function (DUF3345), 0.0078 PF00079 Serpin (serine protease inhibitor), 0.0070 PF00191 Annexin 0.0068 PF02798 Glutathione S-transferase, N-terminal domain 0.0065 PF00043 Glutathione S-transferase, C-terminal domain 0.0058 PF00155 Aminotransferase class I and II 0.0055 PF00202 Aminotransferase class-III 0.0046 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0046 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0037 PF00464 Serine hydroxymethyltransferase 0.0036 PF09396 Thrombin light chain 0.0028 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0022 PF00151 Lipase 0.0021 PF01268 Formate--tetrahydrofolate ligase 0.0020 PF00822 PMP-22/EMP/MP20/Claudin family 0.0020 PF00024 PAN domain 0.0019 PF00733 Asparagine synthase 0.0015 PF02155 Glucocorticoid receptor 0.0014 PF02574 Homocysteine S-methyltransferase 0.0013 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0013 PF00375 Sodium:dicarboxylate symporter family 0.0012 PF01490 Transmembrane amino acid transporter protein 0.0012 PF01126 Heme oxygenase 0.0010 PF00039 Fibronectin type I domain 0.0010 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0010 PF00764 Arginosuccinate synthase 0.0010 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0010 PF00490 Delta-aminolevulinic acid dehydratase 0.0008 PF00255 Glutathione peroxidase 0.0007 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0006 PF00458 WHEP-TRS domain 0.0005 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0005 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0005 PF07706 Aminotransferase ubiquitination site 0.0005 PF07648 Kazal-type serine protease inhibitor domain 0.0005 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0004 PF04960 Glutaminase 0.0001 PF00854 POT family SUB119 >= 1 saturated or aromatic heteroatom-containing ring size 3 0.0609 PF03953 Tubulin C-terminal domain 0.0609 PF00091 Tubulin/FtsZ family, GTPase domain 0.0088 PF07884 Vitamin K epoxide reductase family 0.0081 PF00018 SH3 domain 0.0072 PF00017 SH2 domain 0.0071 PF04679 ATP dependent DNA ligase C terminal region 0.0071 PF01068 ATP dependent DNA ligase domain 0.0070 PF01770 Reduced folate carrier 0.0068 PF08919 F-actin binding 0.0061 PF00102 Protein-tyrosine phosphatase 0.0058 PF00194 Eukaryotic-type carbonic anhydrase 0.0049 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0048 PF00536 SAM domain (Sterile alpha motif), 0.0048 PF01404 Ephrin receptor ligand binding domain 0.0039 PF00854 POT family 0.0033 PF02864 STAT protein, DNA binding domain 0.0033 PF01017 STAT protein, all-alpha domain 0.0033 PF00478 IMP dehydrogenase / GMP reductase domain 0.0033 PF02865 STAT protein, protein interaction domain 0.0031 PF00377 Prion/Doppel alpha-helical domain 0.0031 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0031 PF02059 Interleukin-3 0.0031 PF00183 Hsp90 protein 0.0031 PF00656 Caspase domain 0.0030 PF02394 Interleukin-1 propeptide 0.0030 PF00340 Interleukin-1 / 18 0.0027 PF00962 Adenosine/AMP deaminase 0.0022 PF01023 S-100/ICaBP type calcium binding domain 0.0021 PF00156 Phosphoribosyl transferase domain 0.0021 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0020 PF00069 Protein kinase domain 0.0020 PF00020 TNFR/NGFR cysteine-rich region 0.0020 PF10397 Adenylosuccinate lyase C-terminus 0.0020 PF03098 Animal haem peroxidase 0.0018 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0017 PF00619 Caspase recruitment domain 0.0017 PF00958 GMP synthase C terminal domain 0.0017 PF00341 Platelet-derived growth factor (PDGF), 0.0016 PF02525 Flavodoxin-like fold 0.0015 PF00305 Lipoxygenase 0.0014 PF09396 Thrombin light chain 0.0014 PF00040 Fibronectin type II domain 0.0013 PF12497 Estrogen receptor beta 0.0013 PF00041 Fibronectin type III domain 0.0012 PF00531 Death domain 0.0012 PF00206 Lyase 0.0011 PF02155 Glucocorticoid receptor 0.0010 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0008 PF00001 7 transmembrane receptor (rhodopsin family), 0.0007 PF00273 Serum albumin family 0.0006 PF00709 Adenylosuccinate synthetase 0.0006 PF01477 PLAT/LH2 domain 0.0006 PF00117 Glutamine amidotransferase class-I 0.0005 PF00310 Glutamine amidotransferases class-II 0.0005 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0005 PF00245 Alkaline phosphatase 0.0005 PF00230 Major intrinsic protein 0.0005 PF00571 CBS domain 0.0004 PF02254 TrkA-N domain 0.0004 PF00689 Cation transporting ATPase, C-terminus 0.0004 PF00287 Sodium / potassium ATPase beta chain 0.0004 PF00690 Cation transporter/ATPase, N-terminus 0.0004 PF01425 Amidase 0.0004 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0003 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0003 PF01731 Arylesterase 0.0003 PF07677 A-macroglobulin receptor 0.0003 PF07678 A-macroglobulin complement component 0.0003 PF01835 MG2 domain 0.0002 PF00122 E1-E2 ATPase 0.0001 PF11857 Domain of unknown function (DUF3377), 0.0001 PF08403 Amino acid permease N-terminal SUB573 N:C:N:C 0.0607 PF00186 Dihydrofolate reductase 0.0323 PF00069 Protein kinase domain 0.0272 PF00478 IMP dehydrogenase / GMP reductase domain 0.0238 PF08240 Alcohol dehydrogenase GroES-like domain 0.0214 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0210 PF00107 Zinc-binding dehydrogenase 0.0207 PF01048 Phosphorylase superfamily 0.0195 PF00106 short chain dehydrogenase 0.0179 PF00571 CBS domain 0.0135 PF00962 Adenosine/AMP deaminase 0.0130 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0130 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0130 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0130 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0130 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0109 PF00171 Aldehyde dehydrogenase family 0.0087 PF00018 SH3 domain 0.0087 PF00248 Aldo/keto reductase family 0.0083 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0083 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0079 PF02223 Thymidylate kinase 0.0071 PF00156 Phosphoribosyl transferase domain 0.0065 PF01122 Eukaryotic cobalamin-binding protein 0.0063 PF00017 SH2 domain 0.0061 PF00501 AMP-binding enzyme 0.0054 PF08919 F-actin binding 0.0049 PF01467 Cytidylyltransferase 0.0048 PF02310 B12 binding domain 0.0045 PF03308 ArgK protein 0.0045 PF01923 Cobalamin adenosyltransferase 0.0045 PF01642 Methylmalonyl-CoA mutase 0.0038 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0038 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0038 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0037 PF00225 Kinesin motor domain 0.0033 PF01230 HIT domain 0.0033 PF00970 Oxidoreductase FAD-binding domain 0.0032 PF03949 Malic enzyme, NAD binding domain 0.0032 PF02036 SCP-2 sterol transfer family 0.0032 PF01575 MaoC like domain 0.0032 PF00390 Malic enzyme, N-terminal domain 0.0031 PF00498 FHA domain 0.0031 PF12423 Kinesin protein 1B 0.0031 PF08676 MutL C terminal dimerisation domain 0.0031 PF12473 Kinesin protein 0.0031 PF08996 DNA Polymerase alpha zinc finger 0.0031 PF00136 DNA polymerase family B 0.0031 PF01119 DNA mismatch repair protein, C-terminal domain 0.0031 PF03104 DNA polymerase family B, exonuclease domain 0.0030 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0030 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0029 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0029 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0027 PF02233 NAD(P), transhydrogenase beta subunit 0.0026 PF00400 WD domain, G-beta repeat 0.0026 PF00931 NB-ARC domain 0.0025 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0025 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0023 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0022 PF02607 B12 binding domain 0.0022 PF03770 Inositol polyphosphate kinase 0.0022 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0022 PF00809 Pterin binding enzyme 0.0021 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0021 PF00431 CUB domain 0.0021 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0020 PF03477 ATP cone domain 0.0020 PF00258 Flavodoxin 0.0020 PF00667 FAD binding domain 0.0020 PF00175 Oxidoreductase NAD-binding domain 0.0020 PF02867 Ribonucleotide reductase, barrel domain 0.0020 PF00317 Ribonucleotide reductase, all-alpha domain 0.0018 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0018 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0014 PF07645 Calcium-binding EGF domain 0.0011 PF02574 Homocysteine S-methyltransferase 0.0010 PF01268 Formate--tetrahydrofolate ligase 0.0009 PF00757 Furin-like cysteine rich region 0.0009 PF01030 Receptor L domain 0.0009 PF00858 Amiloride-sensitive sodium channel 0.0007 PF00676 Dehydrogenase E1 component 0.0007 PF00378 Enoyl-CoA hydratase/isomerase family 0.0007 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0006 PF01064 Activin types I and II receptor domain 0.0006 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0006 PF08515 Transforming growth factor beta type I GS-motif 0.0005 PF01126 Heme oxygenase 0.0003 PF02267 ADP-ribosyl cyclase 0.0003 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0002 PF01370 NAD dependent epimerase/dehydratase family 0.0002 PF01687 Riboflavin kinase 0.0002 PF01652 Eukaryotic initiation factor 4E 0.0002 PF02525 Flavodoxin-like fold 0.0002 PF00057 Low-density lipoprotein receptor domain class A 0.0002 PF00058 Low-density lipoprotein receptor repeat class B 0.0002 PF00005 ABC transporter 0.0001 PF01437 Plexin repeat 0.0001 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0001 PF00348 Polyprenyl synthetase 0.0001 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0001 PF02779 Transketolase, pyrimidine binding domain 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF00794 PI3-kinase family, ras-binding domain 0.0001 PF00792 Phosphoinositide 3-kinase C2 0.0001 PF05347 Complex 1 protein (LYR family), 0.0001 PF01403 Sema domain 0.0001 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0001 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0001 PF01833 IPT/TIG domain 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0001 PF01208 Uroporphyrinogen decarboxylase (URO-D), SUB692 O-C-C-C-C-C-N 0.0604 PF08070 DTHCT (NUC029), region 0.0604 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0604 PF00204 DNA gyrase B 0.0406 PF00186 Dihydrofolate reductase 0.0369 PF01048 Phosphorylase superfamily 0.0354 PF00001 7 transmembrane receptor (rhodopsin family), 0.0324 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0321 PF00069 Protein kinase domain 0.0238 PF00478 IMP dehydrogenase / GMP reductase domain 0.0176 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0141 PF08240 Alcohol dehydrogenase GroES-like domain 0.0137 PF00571 CBS domain 0.0125 PF00107 Zinc-binding dehydrogenase 0.0110 PF00962 Adenosine/AMP deaminase 0.0109 PF00017 SH2 domain 0.0106 PF02223 Thymidylate kinase 0.0105 PF00018 SH3 domain 0.0094 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0092 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0092 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0084 PF00106 short chain dehydrogenase 0.0076 PF01590 GAF domain 0.0066 PF08919 F-actin binding 0.0065 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0053 PF00005 ABC transporter 0.0050 PF00858 Amiloride-sensitive sodium channel 0.0044 PF01467 Cytidylyltransferase 0.0043 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0043 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0043 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0037 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0035 PF00171 Aldehyde dehydrogenase family 0.0032 PF00156 Phosphoribosyl transferase domain 0.0029 PF03073 TspO/MBR family 0.0025 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0025 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0020 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0009 PF01687 Riboflavin kinase 0.0008 PF01061 ABC-2 type transporter 0.0008 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0008 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0006 PF02267 ADP-ribosyl cyclase 0.0005 PF00664 ABC transporter transmembrane region 0.0002 PF02036 SCP-2 sterol transfer family 0.0002 PF01575 MaoC like domain 0.0002 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0001 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 0.0604 PF01122 Eukaryotic cobalamin-binding protein 0.0447 PF02310 B12 binding domain 0.0424 PF01923 Cobalamin adenosyltransferase 0.0424 PF01642 Methylmalonyl-CoA mutase 0.0424 PF03308 ArgK protein 0.0202 PF00809 Pterin binding enzyme 0.0202 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0202 PF02607 B12 binding domain 0.0197 PF00431 CUB domain 0.0186 PF00667 FAD binding domain 0.0186 PF00258 Flavodoxin 0.0182 PF00175 Oxidoreductase NAD-binding domain 0.0129 PF07645 Calcium-binding EGF domain 0.0104 PF02574 Homocysteine S-methyltransferase 0.0057 PF02223 Thymidylate kinase 0.0052 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0047 PF08240 Alcohol dehydrogenase GroES-like domain 0.0046 PF00106 short chain dehydrogenase 0.0041 PF00107 Zinc-binding dehydrogenase 0.0041 PF00478 IMP dehydrogenase / GMP reductase domain 0.0038 PF01126 Heme oxygenase 0.0037 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0034 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0034 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0034 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0034 PF00171 Aldehyde dehydrogenase family 0.0034 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0034 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0032 PF00571 CBS domain 0.0032 PF00248 Aldo/keto reductase family 0.0032 PF02267 ADP-ribosyl cyclase 0.0029 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0029 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0025 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0024 PF01467 Cytidylyltransferase 0.0023 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0023 PF00970 Oxidoreductase FAD-binding domain 0.0021 PF01652 Eukaryotic initiation factor 4E 0.0020 PF02233 NAD(P), transhydrogenase beta subunit 0.0019 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0019 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0019 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0019 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0019 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0017 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0017 PF02036 SCP-2 sterol transfer family 0.0017 PF01575 MaoC like domain 0.0017 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0017 PF03770 Inositol polyphosphate kinase 0.0017 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0016 PF00057 Low-density lipoprotein receptor domain class A 0.0016 PF00058 Low-density lipoprotein receptor repeat class B 0.0016 PF01687 Riboflavin kinase 0.0016 PF03949 Malic enzyme, NAD binding domain 0.0016 PF01370 NAD dependent epimerase/dehydratase family 0.0016 PF00390 Malic enzyme, N-terminal domain 0.0015 PF01268 Formate--tetrahydrofolate ligase 0.0014 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0014 PF02525 Flavodoxin-like fold 0.0014 PF00069 Protein kinase domain 0.0014 PF00676 Dehydrogenase E1 component 0.0014 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0014 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0013 PF00186 Dihydrofolate reductase 0.0013 PF00348 Polyprenyl synthetase 0.0013 PF00017 SH2 domain 0.0011 PF00018 SH3 domain 0.0010 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0010 PF05347 Complex 1 protein (LYR family), 0.0010 PF01230 HIT domain 0.0010 PF00378 Enoyl-CoA hydratase/isomerase family 0.0009 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0008 PF01437 Plexin repeat 0.0008 PF02779 Transketolase, pyrimidine binding domain 0.0008 PF01833 IPT/TIG domain 0.0008 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0008 PF01403 Sema domain 0.0008 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0007 PF08676 MutL C terminal dimerisation domain 0.0007 PF12423 Kinesin protein 1B 0.0007 PF00501 AMP-binding enzyme 0.0007 PF01119 DNA mismatch repair protein, C-terminal domain 0.0007 PF12473 Kinesin protein 0.0007 PF00498 FHA domain 0.0005 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0005 PF00794 PI3-kinase family, ras-binding domain 0.0005 PF00792 Phosphoinositide 3-kinase C2 0.0005 PF00400 WD domain, G-beta repeat 0.0005 PF00931 NB-ARC domain 0.0005 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0005 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0004 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0004 PF04800 ETC complex I subunit conserved region 0.0004 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0004 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0004 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0004 PF02466 Tim17/Tim22/Tim23 family 0.0004 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0004 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0004 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0004 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0004 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0004 PF10276 Zinc-finger domain 0.0004 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0004 PF00225 Kinesin motor domain 0.0004 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0004 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0004 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0004 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0004 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0004 PF01808 AICARFT/IMPCHase bienzyme 0.0004 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0004 PF04716 ETC complex I subunit conserved region 0.0004 PF06212 GRIM-19 protein 0.0004 PF09166 Biliverdin reductase, catalytic 0.0004 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0004 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0004 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0004 PF09326 Domain of unknown function (DUF1982), 0.0004 PF02817 e3 binding domain 0.0004 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0004 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0004 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0004 PF08040 MNLL subunit 0.0004 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0004 PF04116 Fatty acid hydroxylase superfamily 0.0004 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0004 PF10531 SLBB domain 0.0004 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0004 PF01712 Deoxynucleoside kinase 0.0004 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0004 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0004 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0004 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0004 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0004 PF00384 Molybdopterin oxidoreductase 0.0003 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0003 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0002 PF00962 Adenosine/AMP deaminase 0.0002 PF03435 Saccharopine dehydrogenase 0.0002 PF02173 pKID domain 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0002 PF02780 Transketolase, C-terminal domain 0.0001 PF00406 Adenylate kinase 0.0001 PF01064 Activin types I and II receptor domain 0.0001 PF00042 Globin 0.0001 PF00170 bZIP transcription factor 0.0001 PF08515 Transforming growth factor beta type I GS-motif SUB287 C-O 0.0579 PF03098 Animal haem peroxidase 0.0431 PF00273 Serum albumin family 0.0333 PF01401 Angiotensin-converting enzyme 0.0312 PF08070 DTHCT (NUC029), region 0.0312 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0312 PF00204 DNA gyrase B 0.0190 PF00105 Zinc finger, C4 type (two domains), 0.0188 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0160 PF03953 Tubulin C-terminal domain 0.0160 PF00091 Tubulin/FtsZ family, GTPase domain 0.0151 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0139 PF00576 HIUase/Transthyretin family 0.0138 PF00102 Protein-tyrosine phosphatase 0.0118 PF01063 Aminotransferase class IV 0.0104 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0098 PF01431 Peptidase family M13 0.0098 PF05649 Peptidase family M13 0.0085 PF11825 Protein of unknown function (DUF3345), 0.0074 PF00079 Serpin (serine protease inhibitor), 0.0066 PF00191 Annexin 0.0064 PF02798 Glutathione S-transferase, N-terminal domain 0.0062 PF00043 Glutathione S-transferase, C-terminal domain 0.0055 PF00155 Aminotransferase class I and II 0.0052 PF00202 Aminotransferase class-III 0.0043 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0043 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0035 PF00464 Serine hydroxymethyltransferase 0.0034 PF09396 Thrombin light chain 0.0026 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0021 PF00151 Lipase 0.0020 PF01268 Formate--tetrahydrofolate ligase 0.0019 PF00024 PAN domain 0.0019 PF00822 PMP-22/EMP/MP20/Claudin family 0.0018 PF00733 Asparagine synthase 0.0014 PF02155 Glucocorticoid receptor 0.0013 PF02574 Homocysteine S-methyltransferase 0.0012 PF00375 Sodium:dicarboxylate symporter family 0.0012 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0012 PF01126 Heme oxygenase 0.0011 PF01490 Transmembrane amino acid transporter protein 0.0010 PF00039 Fibronectin type I domain 0.0010 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0010 PF00764 Arginosuccinate synthase 0.0010 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0010 PF00490 Delta-aminolevulinic acid dehydratase 0.0008 PF00255 Glutathione peroxidase 0.0007 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0006 PF00458 WHEP-TRS domain 0.0005 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0005 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0005 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0005 PF07706 Aminotransferase ubiquitination site 0.0004 PF07648 Kazal-type serine protease inhibitor domain 0.0003 PF04960 Glutaminase 0.0001 PF00854 POT family SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 0.0572 PF00001 7 transmembrane receptor (rhodopsin family), 0.0140 PF03073 TspO/MBR family 0.0113 PF08070 DTHCT (NUC029), region 0.0113 PF00204 DNA gyrase B 0.0113 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0107 PF00186 Dihydrofolate reductase 0.0098 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0097 PF00069 Protein kinase domain 0.0092 PF01048 Phosphorylase superfamily 0.0090 PF00005 ABC transporter 0.0089 PF00209 Sodium:neurotransmitter symporter family 0.0088 PF01401 Angiotensin-converting enzyme 0.0086 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0085 PF06512 Sodium ion transport-associated 0.0077 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0071 PF00664 ABC transporter transmembrane region 0.0055 PF00989 PAS fold 0.0050 PF01593 Flavin containing amine oxidoreductase 0.0049 PF00520 Ion transport protein 0.0045 PF00027 Cyclic nucleotide-binding domain 0.0045 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0045 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0036 PF00478 IMP dehydrogenase / GMP reductase domain 0.0030 PF00017 SH2 domain 0.0021 PF08240 Alcohol dehydrogenase GroES-like domain 0.0021 PF00571 CBS domain 0.0021 PF00091 Tubulin/FtsZ family, GTPase domain 0.0021 PF03953 Tubulin C-terminal domain 0.0019 PF00018 SH3 domain 0.0019 PF00107 Zinc-binding dehydrogenase 0.0018 PF00962 Adenosine/AMP deaminase 0.0018 PF02223 Thymidylate kinase 0.0017 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0017 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0016 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0016 PF02180 Bcl-2 homology region 4 0.0015 PF01061 ABC-2 type transporter 0.0015 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0015 PF08919 F-actin binding 0.0014 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0014 PF08983 Domain of unknown function (DUF1856), 0.0013 PF00106 short chain dehydrogenase 0.0011 PF01590 GAF domain 0.0009 PF01467 Cytidylyltransferase 0.0008 PF00858 Amiloride-sensitive sodium channel 0.0006 PF08491 Squalene epoxidase 0.0006 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0006 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0006 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0006 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0006 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0006 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0005 PF00171 Aldehyde dehydrogenase family 0.0005 PF00156 Phosphoribosyl transferase domain 0.0004 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0004 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0003 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0001 PF02267 ADP-ribosyl cyclase 0.0001 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0001 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0001 PF01687 Riboflavin kinase 0.0001 PF01126 Heme oxygenase SUB834 NC1C(N)CCCC1 0.0571 PF00689 Cation transporting ATPase, C-terminus 0.0571 PF00690 Cation transporter/ATPase, N-terminus 0.0524 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0510 PF00122 E1-E2 ATPase 0.0491 PF01122 Eukaryotic cobalamin-binding protein 0.0463 PF00702 haloacid dehalogenase-like hydrolase 0.0361 PF02310 B12 binding domain 0.0345 PF01642 Methylmalonyl-CoA mutase 0.0345 PF01923 Cobalamin adenosyltransferase 0.0345 PF03308 ArgK protein 0.0178 PF00667 FAD binding domain 0.0178 PF00258 Flavodoxin 0.0175 PF00175 Oxidoreductase NAD-binding domain 0.0161 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0161 PF02607 B12 binding domain 0.0161 PF00809 Pterin binding enzyme 0.0157 PF00431 CUB domain 0.0126 PF00287 Sodium / potassium ATPase beta chain 0.0116 PF03953 Tubulin C-terminal domain 0.0116 PF00091 Tubulin/FtsZ family, GTPase domain 0.0101 PF07645 Calcium-binding EGF domain 0.0090 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0088 PF00146 NADH dehydrogenase 0.0086 PF00194 Eukaryotic-type carbonic anhydrase 0.0081 PF02574 Homocysteine S-methyltransferase 0.0054 PF00478 IMP dehydrogenase / GMP reductase domain 0.0047 PF02214 K+ channel tetramerisation domain 0.0044 PF02223 Thymidylate kinase 0.0042 PF00017 SH2 domain 0.0041 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0038 PF00018 SH3 domain 0.0037 PF08240 Alcohol dehydrogenase GroES-like domain 0.0036 PF02254 TrkA-N domain 0.0036 PF00230 Major intrinsic protein 0.0036 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0035 PF00106 short chain dehydrogenase 0.0033 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0033 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0033 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0032 PF00107 Zinc-binding dehydrogenase 0.0032 PF00102 Protein-tyrosine phosphatase 0.0032 PF02898 Nitric oxide synthase, oxygenase domain 0.0031 PF00571 CBS domain 0.0031 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0029 PF12497 Estrogen receptor beta 0.0029 PF01126 Heme oxygenase 0.0028 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0027 PF00171 Aldehyde dehydrogenase family 0.0027 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0027 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0025 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0025 PF02267 ADP-ribosyl cyclase 0.0025 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0025 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0025 PF00248 Aldo/keto reductase family 0.0025 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0025 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0025 PF01687 Riboflavin kinase 0.0024 PF04679 ATP dependent DNA ligase C terminal region 0.0024 PF00970 Oxidoreductase FAD-binding domain 0.0024 PF01068 ATP dependent DNA ligase domain 0.0023 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0023 PF01770 Reduced folate carrier 0.0023 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0022 PF00631 GGL domain 0.0022 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0021 PF08919 F-actin binding 0.0021 PF00962 Adenosine/AMP deaminase 0.0020 PF03073 TspO/MBR family 0.0019 PF02888 Calmodulin binding domain 0.0019 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0019 PF01467 Cytidylyltransferase 0.0019 PF03530 Calcium-activated SK potassium channel 0.0018 PF00520 Ion transport protein 0.0017 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0016 PF01652 Eukaryotic initiation factor 4E 0.0016 PF00069 Protein kinase domain 0.0015 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0015 PF00536 SAM domain (Sterile alpha motif), 0.0015 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0015 PF02233 NAD(P), transhydrogenase beta subunit 0.0015 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0015 PF00794 PI3-kinase family, ras-binding domain 0.0015 PF00792 Phosphoinositide 3-kinase C2 0.0015 PF00273 Serum albumin family 0.0015 PF00854 POT family 0.0015 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0015 PF10397 Adenylosuccinate lyase C-terminus 0.0015 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0015 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0015 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0015 PF01404 Ephrin receptor ligand binding domain 0.0014 PF00156 Phosphoribosyl transferase domain 0.0013 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0013 PF03770 Inositol polyphosphate kinase 0.0013 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0013 PF00390 Malic enzyme, N-terminal domain 0.0013 PF03949 Malic enzyme, NAD binding domain 0.0013 PF01833 IPT/TIG domain 0.0013 PF00958 GMP synthase C terminal domain 0.0013 PF01403 Sema domain 0.0013 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0013 PF02036 SCP-2 sterol transfer family 0.0013 PF01575 MaoC like domain 0.0013 PF01437 Plexin repeat 0.0012 PF01268 Formate--tetrahydrofolate ligase 0.0012 PF01370 NAD dependent epimerase/dehydratase family 0.0012 PF00058 Low-density lipoprotein receptor repeat class B 0.0012 PF00057 Low-density lipoprotein receptor domain class A 0.0011 PF00676 Dehydrogenase E1 component 0.0011 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0011 PF02865 STAT protein, protein interaction domain 0.0011 PF02864 STAT protein, DNA binding domain 0.0011 PF02525 Flavodoxin-like fold 0.0011 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0011 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0011 PF01017 STAT protein, all-alpha domain 0.0010 PF00186 Dihydrofolate reductase 0.0010 PF00206 Lyase 0.0010 PF00348 Polyprenyl synthetase 0.0008 PF08403 Amino acid permease N-terminal 0.0008 PF00060 Ligand-gated ion channel 0.0008 PF00378 Enoyl-CoA hydratase/isomerase family 0.0008 PF01230 HIT domain 0.0007 PF05347 Complex 1 protein (LYR family), 0.0007 PF00489 Interleukin-6/G-CSF/MGF family 0.0007 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0007 PF02441 Flavoprotein 0.0007 PF00191 Annexin 0.0007 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0007 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0006 PF00654 Voltage gated chloride channel 0.0006 PF02779 Transketolase, pyrimidine binding domain 0.0006 PF00245 Alkaline phosphatase 0.0006 PF08377 MAP2/Tau projection domain 0.0006 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0006 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0006 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0006 PF07885 Ion channel 0.0006 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0006 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0006 PF00576 HIUase/Transthyretin family 0.0005 PF01119 DNA mismatch repair protein, C-terminal domain 0.0005 PF00498 FHA domain 0.0005 PF08676 MutL C terminal dimerisation domain 0.0005 PF00405 Transferrin 0.0005 PF00117 Glutamine amidotransferase class-I 0.0005 PF00625 Guanylate kinase 0.0005 PF00459 Inositol monophosphatase family 0.0005 PF00709 Adenylosuccinate synthetase 0.0005 PF12473 Kinesin protein 0.0005 PF00501 AMP-binding enzyme 0.0005 PF12423 Kinesin protein 1B 0.0004 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0004 PF07677 A-macroglobulin receptor 0.0004 PF07678 A-macroglobulin complement component 0.0004 PF08063 PADR1 (NUC008), domain 0.0004 PF01835 MG2 domain 0.0004 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0004 PF01007 Inward rectifier potassium channel 0.0004 PF00779 BTK motif 0.0004 PF00931 NB-ARC domain 0.0004 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0004 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0004 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0004 PF00533 BRCA1 C Terminus (BRCT), domain 0.0004 PF01180 Dihydroorotate dehydrogenase 0.0004 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0004 PF02196 Raf-like Ras-binding domain 0.0004 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0004 PF00400 WD domain, G-beta repeat 0.0004 PF05406 WGR domain 0.0003 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0003 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0003 PF04800 ETC complex I subunit conserved region 0.0003 PF00406 Adenylate kinase 0.0003 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0003 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0003 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0003 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0003 PF02817 e3 binding domain 0.0003 PF00089 Trypsin 0.0003 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0003 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0003 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0003 PF09166 Biliverdin reductase, catalytic 0.0003 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0003 PF09326 Domain of unknown function (DUF1982), 0.0003 PF00384 Molybdopterin oxidoreductase 0.0003 PF00994 Probable molybdopterin binding domain 0.0003 PF00042 Globin 0.0003 PF00514 Armadillo/beta-catenin-like repeat 0.0003 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0003 PF01094 Receptor family ligand binding region 0.0003 PF04116 Fatty acid hydroxylase superfamily 0.0003 PF00225 Kinesin motor domain 0.0003 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0003 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0003 PF00134 Cyclin, N-terminal domain 0.0003 PF01808 AICARFT/IMPCHase bienzyme 0.0003 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0003 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0003 PF04716 ETC complex I subunit conserved region 0.0003 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0003 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0003 PF02828 L27 domain 0.0003 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0003 PF12126 Protein of unknown function (DUF3583), 0.0003 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0003 PF06212 GRIM-19 protein 0.0003 PF02743 Cache domain 0.0003 PF07970 Endoplasmic reticulum vesicle transporter 0.0003 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0003 PF10531 SLBB domain 0.0003 PF08040 MNLL subunit 0.0003 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0003 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0003 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0003 PF10276 Zinc-finger domain 0.0003 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0003 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0003 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0003 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0003 PF02984 Cyclin, C-terminal domain 0.0003 PF01712 Deoxynucleoside kinase 0.0003 PF02466 Tim17/Tim22/Tim23 family 0.0003 PF03453 MoeA N-terminal region (domain I and II), 0.0003 PF03454 MoeA C-terminal region (domain IV), 0.0003 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0003 PF08399 VWA N-terminal 0.0003 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0003 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0003 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0002 PF00303 Thymidylate synthase 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0002 PF00310 Glutamine amidotransferases class-II 0.0002 PF00462 Glutaredoxin 0.0002 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0002 PF02173 pKID domain 0.0002 PF01369 Sec7 domain 0.0002 PF00675 Insulinase (Peptidase family M16), 0.0002 PF00989 PAS fold 0.0002 PF05193 Peptidase M16 inactive domain 0.0002 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0001 PF02780 Transketolase, C-terminal domain 0.0001 PF00041 Fibronectin type III domain 0.0001 PF07653 Variant SH3 domain 0.0001 PF02189 Immunoreceptor tyrosine-based activation motif 0.0001 PF08763 Voltage gated calcium channel IQ domain 0.0001 PF03435 Saccharopine dehydrogenase 0.0001 PF01426 BAH domain 0.0001 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0001 PF03957 Jun-like transcription factor 0.0001 PF00027 Cyclic nucleotide-binding domain 0.0001 PF01064 Activin types I and II receptor domain 0.0001 PF08515 Transforming growth factor beta type I GS-motif 0.0001 PF02008 CXXC zinc finger domain 0.0001 PF00170 bZIP transcription factor 0.0001 PF01733 Nucleoside transporter 0.0001 PF06617 M-phase inducer phosphatase 0.0001 PF06464 DMAP1-binding Domain 0.0001 PF00581 Rhodanese-like domain SUB771 Nc1c(N)cccc1 0.0571 PF00689 Cation transporting ATPase, C-terminus 0.0571 PF00690 Cation transporter/ATPase, N-terminus 0.0524 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0510 PF00122 E1-E2 ATPase 0.0491 PF01122 Eukaryotic cobalamin-binding protein 0.0463 PF00702 haloacid dehalogenase-like hydrolase 0.0361 PF02310 B12 binding domain 0.0345 PF01642 Methylmalonyl-CoA mutase 0.0345 PF03308 ArgK protein 0.0345 PF01923 Cobalamin adenosyltransferase 0.0178 PF00258 Flavodoxin 0.0178 PF00667 FAD binding domain 0.0175 PF00175 Oxidoreductase NAD-binding domain 0.0161 PF02607 B12 binding domain 0.0161 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0161 PF00809 Pterin binding enzyme 0.0157 PF00431 CUB domain 0.0126 PF00287 Sodium / potassium ATPase beta chain 0.0116 PF00091 Tubulin/FtsZ family, GTPase domain 0.0116 PF03953 Tubulin C-terminal domain 0.0101 PF07645 Calcium-binding EGF domain 0.0090 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0088 PF00146 NADH dehydrogenase 0.0086 PF00194 Eukaryotic-type carbonic anhydrase 0.0081 PF02574 Homocysteine S-methyltransferase 0.0054 PF00478 IMP dehydrogenase / GMP reductase domain 0.0047 PF02214 K+ channel tetramerisation domain 0.0044 PF02223 Thymidylate kinase 0.0042 PF00017 SH2 domain 0.0041 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0038 PF00018 SH3 domain 0.0037 PF08240 Alcohol dehydrogenase GroES-like domain 0.0036 PF00230 Major intrinsic protein 0.0036 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0036 PF02254 TrkA-N domain 0.0035 PF00106 short chain dehydrogenase 0.0033 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0033 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0033 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0032 PF00107 Zinc-binding dehydrogenase 0.0032 PF00102 Protein-tyrosine phosphatase 0.0032 PF02898 Nitric oxide synthase, oxygenase domain 0.0031 PF00571 CBS domain 0.0031 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0029 PF01126 Heme oxygenase 0.0029 PF12497 Estrogen receptor beta 0.0028 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0027 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0027 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0027 PF00171 Aldehyde dehydrogenase family 0.0025 PF01687 Riboflavin kinase 0.0025 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0025 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0025 PF00248 Aldo/keto reductase family 0.0025 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0025 PF02267 ADP-ribosyl cyclase 0.0025 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0025 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0024 PF01068 ATP dependent DNA ligase domain 0.0024 PF00970 Oxidoreductase FAD-binding domain 0.0024 PF04679 ATP dependent DNA ligase C terminal region 0.0023 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0023 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0023 PF01770 Reduced folate carrier 0.0022 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0022 PF00631 GGL domain 0.0021 PF00962 Adenosine/AMP deaminase 0.0021 PF08919 F-actin binding 0.0020 PF03073 TspO/MBR family 0.0019 PF02888 Calmodulin binding domain 0.0019 PF03530 Calcium-activated SK potassium channel 0.0019 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0019 PF01467 Cytidylyltransferase 0.0018 PF00520 Ion transport protein 0.0017 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0016 PF00069 Protein kinase domain 0.0016 PF01652 Eukaryotic initiation factor 4E 0.0015 PF00273 Serum albumin family 0.0015 PF00536 SAM domain (Sterile alpha motif), 0.0015 PF00792 Phosphoinositide 3-kinase C2 0.0015 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0015 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0015 PF00794 PI3-kinase family, ras-binding domain 0.0015 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0015 PF00854 POT family 0.0015 PF02233 NAD(P), transhydrogenase beta subunit 0.0015 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0015 PF10397 Adenylosuccinate lyase C-terminus 0.0015 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0015 PF01404 Ephrin receptor ligand binding domain 0.0015 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0015 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0014 PF00156 Phosphoribosyl transferase domain 0.0013 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0013 PF00958 GMP synthase C terminal domain 0.0013 PF03949 Malic enzyme, NAD binding domain 0.0013 PF01403 Sema domain 0.0013 PF01437 Plexin repeat 0.0013 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0013 PF01833 IPT/TIG domain 0.0013 PF03770 Inositol polyphosphate kinase 0.0013 PF01575 MaoC like domain 0.0013 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0013 PF00390 Malic enzyme, N-terminal domain 0.0013 PF02036 SCP-2 sterol transfer family 0.0012 PF00057 Low-density lipoprotein receptor domain class A 0.0012 PF00058 Low-density lipoprotein receptor repeat class B 0.0012 PF01370 NAD dependent epimerase/dehydratase family 0.0012 PF01268 Formate--tetrahydrofolate ligase 0.0011 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0011 PF01017 STAT protein, all-alpha domain 0.0011 PF02525 Flavodoxin-like fold 0.0011 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0011 PF02864 STAT protein, DNA binding domain 0.0011 PF02865 STAT protein, protein interaction domain 0.0011 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0011 PF00676 Dehydrogenase E1 component 0.0010 PF00206 Lyase 0.0010 PF00348 Polyprenyl synthetase 0.0010 PF00186 Dihydrofolate reductase 0.0008 PF08403 Amino acid permease N-terminal 0.0008 PF00378 Enoyl-CoA hydratase/isomerase family 0.0008 PF01230 HIT domain 0.0008 PF00060 Ligand-gated ion channel 0.0007 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0007 PF02441 Flavoprotein 0.0007 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0007 PF00489 Interleukin-6/G-CSF/MGF family 0.0007 PF05347 Complex 1 protein (LYR family), 0.0007 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0007 PF00191 Annexin 0.0006 PF02779 Transketolase, pyrimidine binding domain 0.0006 PF00576 HIUase/Transthyretin family 0.0006 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0006 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0006 PF00245 Alkaline phosphatase 0.0006 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0006 PF08377 MAP2/Tau projection domain 0.0006 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0006 PF07885 Ion channel 0.0006 PF00654 Voltage gated chloride channel 0.0006 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0005 PF00459 Inositol monophosphatase family 0.0005 PF00405 Transferrin 0.0005 PF00498 FHA domain 0.0005 PF12423 Kinesin protein 1B 0.0005 PF00117 Glutamine amidotransferase class-I 0.0005 PF12473 Kinesin protein 0.0005 PF01119 DNA mismatch repair protein, C-terminal domain 0.0005 PF00709 Adenylosuccinate synthetase 0.0005 PF08676 MutL C terminal dimerisation domain 0.0005 PF00501 AMP-binding enzyme 0.0005 PF00625 Guanylate kinase 0.0004 PF00533 BRCA1 C Terminus (BRCT), domain 0.0004 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0004 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0004 PF05406 WGR domain 0.0004 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0004 PF02196 Raf-like Ras-binding domain 0.0004 PF00931 NB-ARC domain 0.0004 PF01180 Dihydroorotate dehydrogenase 0.0004 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0004 PF07678 A-macroglobulin complement component 0.0004 PF07677 A-macroglobulin receptor 0.0004 PF08063 PADR1 (NUC008), domain 0.0004 PF00400 WD domain, G-beta repeat 0.0004 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0004 PF00779 BTK motif 0.0004 PF01835 MG2 domain 0.0004 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0004 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0004 PF01007 Inward rectifier potassium channel 0.0003 PF01808 AICARFT/IMPCHase bienzyme 0.0003 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0003 PF02828 L27 domain 0.0003 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0003 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0003 PF12126 Protein of unknown function (DUF3583), 0.0003 PF10531 SLBB domain 0.0003 PF06212 GRIM-19 protein 0.0003 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0003 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0003 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0003 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0003 PF09326 Domain of unknown function (DUF1982), 0.0003 PF02466 Tim17/Tim22/Tim23 family 0.0003 PF02743 Cache domain 0.0003 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0003 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0003 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0003 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0003 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0003 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0003 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0003 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0003 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0003 PF09166 Biliverdin reductase, catalytic 0.0003 PF02984 Cyclin, C-terminal domain 0.0003 PF08399 VWA N-terminal 0.0003 PF00514 Armadillo/beta-catenin-like repeat 0.0003 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0003 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0003 PF00406 Adenylate kinase 0.0003 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0003 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0003 PF00994 Probable molybdopterin binding domain 0.0003 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0003 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0003 PF02817 e3 binding domain 0.0003 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0003 PF04116 Fatty acid hydroxylase superfamily 0.0003 PF04716 ETC complex I subunit conserved region 0.0003 PF04800 ETC complex I subunit conserved region 0.0003 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0003 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0003 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0003 PF00089 Trypsin 0.0003 PF07970 Endoplasmic reticulum vesicle transporter 0.0003 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0003 PF01094 Receptor family ligand binding region 0.0003 PF00384 Molybdopterin oxidoreductase 0.0003 PF10276 Zinc-finger domain 0.0003 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0003 PF00134 Cyclin, N-terminal domain 0.0003 PF08040 MNLL subunit 0.0003 PF01712 Deoxynucleoside kinase 0.0003 PF00042 Globin 0.0003 PF03453 MoeA N-terminal region (domain I and II), 0.0003 PF03454 MoeA C-terminal region (domain IV), 0.0003 PF00225 Kinesin motor domain 0.0003 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0003 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0003 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0002 PF00989 PAS fold 0.0002 PF00675 Insulinase (Peptidase family M16), 0.0002 PF05193 Peptidase M16 inactive domain 0.0002 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0002 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0002 PF00303 Thymidylate synthase 0.0002 PF02173 pKID domain 0.0002 PF01369 Sec7 domain 0.0002 PF00310 Glutamine amidotransferases class-II 0.0002 PF00462 Glutaredoxin 0.0001 PF00027 Cyclic nucleotide-binding domain 0.0001 PF03435 Saccharopine dehydrogenase 0.0001 PF00170 bZIP transcription factor 0.0001 PF02189 Immunoreceptor tyrosine-based activation motif 0.0001 PF01733 Nucleoside transporter 0.0001 PF07653 Variant SH3 domain 0.0001 PF06617 M-phase inducer phosphatase 0.0001 PF06464 DMAP1-binding Domain 0.0001 PF00581 Rhodanese-like domain 0.0001 PF01426 BAH domain 0.0001 PF02008 CXXC zinc finger domain 0.0001 PF01064 Activin types I and II receptor domain 0.0001 PF08763 Voltage gated calcium channel IQ domain 0.0001 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0001 PF02780 Transketolase, C-terminal domain 0.0001 PF00041 Fibronectin type III domain 0.0001 PF03957 Jun-like transcription factor 0.0001 PF08515 Transforming growth factor beta type I GS-motif SUB446 C(-H)(-N)(=C) 0.0569 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0569 PF08070 DTHCT (NUC029), region 0.0569 PF00204 DNA gyrase B 0.0382 PF00186 Dihydrofolate reductase 0.0347 PF01048 Phosphorylase superfamily 0.0333 PF00001 7 transmembrane receptor (rhodopsin family), 0.0305 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0302 PF00069 Protein kinase domain 0.0224 PF00478 IMP dehydrogenase / GMP reductase domain 0.0165 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0133 PF08240 Alcohol dehydrogenase GroES-like domain 0.0129 PF00571 CBS domain 0.0117 PF00107 Zinc-binding dehydrogenase 0.0104 PF00962 Adenosine/AMP deaminase 0.0103 PF00017 SH2 domain 0.0100 PF02223 Thymidylate kinase 0.0099 PF00018 SH3 domain 0.0089 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0086 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0086 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0079 PF00106 short chain dehydrogenase 0.0072 PF01590 GAF domain 0.0062 PF08919 F-actin binding 0.0061 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0050 PF00005 ABC transporter 0.0047 PF00858 Amiloride-sensitive sodium channel 0.0041 PF01467 Cytidylyltransferase 0.0040 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0040 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0040 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0035 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0033 PF00171 Aldehyde dehydrogenase family 0.0030 PF00156 Phosphoribosyl transferase domain 0.0027 PF03073 TspO/MBR family 0.0024 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0024 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0019 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0009 PF01687 Riboflavin kinase 0.0007 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0007 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0007 PF01061 ABC-2 type transporter 0.0006 PF02267 ADP-ribosyl cyclase 0.0005 PF00664 ABC transporter transmembrane region 0.0002 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0001 PF02036 SCP-2 sterol transfer family 0.0001 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0001 PF01575 MaoC like domain SUB25 >= 2 F 0.0537 PF00689 Cation transporting ATPase, C-terminus 0.0537 PF00690 Cation transporter/ATPase, N-terminus 0.0478 PF00122 E1-E2 ATPase 0.0432 PF00702 haloacid dehalogenase-like hydrolase 0.0373 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0340 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0338 PF00146 NADH dehydrogenase 0.0200 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0200 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0197 PF02254 TrkA-N domain 0.0197 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0159 PF00194 Eukaryotic-type carbonic anhydrase 0.0139 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0139 PF00631 GGL domain 0.0138 PF02888 Calmodulin binding domain 0.0138 PF03530 Calcium-activated SK potassium channel 0.0133 PF02214 K+ channel tetramerisation domain 0.0106 PF00191 Annexin 0.0100 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0090 PF00287 Sodium / potassium ATPase beta chain 0.0087 PF01007 Inward rectifier potassium channel 0.0083 PF00091 Tubulin/FtsZ family, GTPase domain 0.0083 PF03953 Tubulin C-terminal domain 0.0078 PF12497 Estrogen receptor beta 0.0072 PF00520 Ion transport protein 0.0069 PF00273 Serum albumin family 0.0059 PF07885 Ion channel 0.0054 PF00060 Ligand-gated ion channel 0.0050 PF08403 Amino acid permease N-terminal 0.0042 PF02155 Glucocorticoid receptor 0.0038 PF02159 Oestrogen receptor 0.0037 PF01094 Receptor family ligand binding region 0.0029 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0029 PF08377 MAP2/Tau projection domain 0.0028 PF00102 Protein-tyrosine phosphatase 0.0026 PF00230 Major intrinsic protein 0.0025 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0024 PF00667 FAD binding domain 0.0024 PF00079 Serpin (serine protease inhibitor), 0.0024 PF00258 Flavodoxin 0.0023 PF01426 BAH domain 0.0023 PF06464 DMAP1-binding Domain 0.0023 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0023 PF02898 Nitric oxide synthase, oxygenase domain 0.0023 PF00175 Oxidoreductase NAD-binding domain 0.0023 PF02008 CXXC zinc finger domain 0.0022 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0022 PF00017 SH2 domain 0.0022 PF00018 SH3 domain 0.0018 PF03073 TspO/MBR family 0.0018 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0017 PF04679 ATP dependent DNA ligase C terminal region 0.0017 PF01068 ATP dependent DNA ligase domain 0.0016 PF01770 Reduced folate carrier 0.0016 PF00478 IMP dehydrogenase / GMP reductase domain 0.0015 PF01122 Eukaryotic cobalamin-binding protein 0.0015 PF08919 F-actin binding 0.0014 PF00962 Adenosine/AMP deaminase 0.0013 PF00324 Amino acid permease 0.0012 PF00145 C-5 cytosine-specific DNA methylase 0.0012 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0011 PF10397 Adenylosuccinate lyase C-terminus 0.0011 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0011 PF01404 Ephrin receptor ligand binding domain 0.0011 PF00536 SAM domain (Sterile alpha motif), 0.0011 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0011 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0011 PF00854 POT family 0.0010 PF00462 Glutaredoxin 0.0010 PF02310 B12 binding domain 0.0010 PF03308 ArgK protein 0.0010 PF00156 Phosphoribosyl transferase domain 0.0010 PF01923 Cobalamin adenosyltransferase 0.0010 PF01642 Methylmalonyl-CoA mutase 0.0010 PF00576 HIUase/Transthyretin family 0.0010 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0009 PF01687 Riboflavin kinase 0.0009 PF00958 GMP synthase C terminal domain 0.0008 PF02865 STAT protein, protein interaction domain 0.0008 PF02864 STAT protein, DNA binding domain 0.0008 PF01017 STAT protein, all-alpha domain 0.0008 PF00794 PI3-kinase family, ras-binding domain 0.0008 PF00792 Phosphoinositide 3-kinase C2 0.0008 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0007 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0007 PF00206 Lyase 0.0005 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0005 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0005 PF01437 Plexin repeat 0.0005 PF01403 Sema domain 0.0005 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0005 PF00571 CBS domain 0.0005 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0005 PF01833 IPT/TIG domain 0.0005 PF02441 Flavoprotein 0.0005 PF00489 Interleukin-6/G-CSF/MGF family 0.0005 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0004 PF00245 Alkaline phosphatase 0.0004 PF00709 Adenylosuccinate synthetase 0.0004 PF00069 Protein kinase domain 0.0004 PF00654 Voltage gated chloride channel 0.0004 PF00405 Transferrin 0.0004 PF00625 Guanylate kinase 0.0004 PF00459 Inositol monophosphatase family 0.0004 PF00970 Oxidoreductase FAD-binding domain 0.0004 PF01735 Lysophospholipase catalytic domain 0.0003 PF00533 BRCA1 C Terminus (BRCT), domain 0.0003 PF08063 PADR1 (NUC008), domain 0.0003 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0003 PF01835 MG2 domain 0.0003 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0003 PF07677 A-macroglobulin receptor 0.0003 PF07678 A-macroglobulin complement component 0.0003 PF00809 Pterin binding enzyme 0.0003 PF02166 Androgen receptor 0.0003 PF00117 Glutamine amidotransferase class-I 0.0003 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0003 PF00105 Zinc finger, C4 type (two domains), 0.0003 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0003 PF00204 DNA gyrase B 0.0003 PF01180 Dihydroorotate dehydrogenase 0.0003 PF00779 BTK motif 0.0003 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0003 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0003 PF02607 B12 binding domain 0.0003 PF02196 Raf-like Ras-binding domain 0.0003 PF00431 CUB domain 0.0003 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0003 PF03522 K-Cl Co-transporter type 1 (KCC1), 0.0003 PF08070 DTHCT (NUC029), region 0.0003 PF05406 WGR domain 0.0003 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0002 PF07970 Endoplasmic reticulum vesicle transporter 0.0002 PF03453 MoeA N-terminal region (domain I and II), 0.0002 PF03454 MoeA C-terminal region (domain IV), 0.0002 PF00989 PAS fold 0.0002 PF00303 Thymidylate synthase 0.0002 PF01369 Sec7 domain 0.0002 PF00994 Probable molybdopterin binding domain 0.0002 PF00134 Cyclin, N-terminal domain 0.0002 PF08399 VWA N-terminal 0.0002 PF02743 Cache domain 0.0002 PF00514 Armadillo/beta-catenin-like repeat 0.0002 PF00089 Trypsin 0.0002 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0002 PF12126 Protein of unknown function (DUF3583), 0.0002 PF02984 Cyclin, C-terminal domain 0.0002 PF00310 Glutamine amidotransferases class-II 0.0002 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.0002 PF02828 L27 domain 0.0001 PF08763 Voltage gated calcium channel IQ domain 0.0001 PF11628 T-cell surface glycoprotein CD3 zeta chain 0.0001 PF00042 Globin 0.0001 PF00041 Fibronectin type III domain 0.0001 PF05193 Peptidase M16 inactive domain 0.0001 PF00027 Cyclic nucleotide-binding domain 0.0001 PF07653 Variant SH3 domain 0.0001 PF03957 Jun-like transcription factor 0.0001 PF01733 Nucleoside transporter 0.0001 PF02189 Immunoreceptor tyrosine-based activation motif 0.0001 PF00406 Adenylate kinase 0.0001 PF00581 Rhodanese-like domain 0.0001 PF00675 Insulinase (Peptidase family M16), 0.0001 PF06617 M-phase inducer phosphatase SUB158 >= 3 any ring size 5 0.0536 PF01122 Eukaryotic cobalamin-binding protein 0.0396 PF02310 B12 binding domain 0.0376 PF01642 Methylmalonyl-CoA mutase 0.0376 PF03308 ArgK protein 0.0376 PF01923 Cobalamin adenosyltransferase 0.0179 PF02607 B12 binding domain 0.0179 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0179 PF00809 Pterin binding enzyme 0.0175 PF00431 CUB domain 0.0165 PF00667 FAD binding domain 0.0165 PF00258 Flavodoxin 0.0162 PF00175 Oxidoreductase NAD-binding domain 0.0115 PF07645 Calcium-binding EGF domain 0.0092 PF02574 Homocysteine S-methyltransferase 0.0051 PF02223 Thymidylate kinase 0.0046 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0042 PF08240 Alcohol dehydrogenase GroES-like domain 0.0040 PF00106 short chain dehydrogenase 0.0037 PF00107 Zinc-binding dehydrogenase 0.0036 PF00478 IMP dehydrogenase / GMP reductase domain 0.0033 PF01126 Heme oxygenase 0.0032 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0030 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0030 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0030 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0030 PF00171 Aldehyde dehydrogenase family 0.0030 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0030 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0028 PF00571 CBS domain 0.0028 PF02267 ADP-ribosyl cyclase 0.0028 PF00248 Aldo/keto reductase family 0.0026 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0026 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0022 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0021 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0021 PF01467 Cytidylyltransferase 0.0020 PF00970 Oxidoreductase FAD-binding domain 0.0019 PF01652 Eukaryotic initiation factor 4E 0.0017 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0017 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0017 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0017 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0017 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0017 PF02233 NAD(P), transhydrogenase beta subunit 0.0015 PF01575 MaoC like domain 0.0015 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0015 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0015 PF03949 Malic enzyme, NAD binding domain 0.0015 PF00390 Malic enzyme, N-terminal domain 0.0015 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0015 PF03770 Inositol polyphosphate kinase 0.0015 PF02036 SCP-2 sterol transfer family 0.0014 PF01268 Formate--tetrahydrofolate ligase 0.0014 PF00058 Low-density lipoprotein receptor repeat class B 0.0014 PF00057 Low-density lipoprotein receptor domain class A 0.0014 PF01370 NAD dependent epimerase/dehydratase family 0.0014 PF01687 Riboflavin kinase 0.0013 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0013 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0013 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0013 PF00676 Dehydrogenase E1 component 0.0012 PF00069 Protein kinase domain 0.0012 PF02525 Flavodoxin-like fold 0.0012 PF00017 SH2 domain 0.0012 PF00348 Polyprenyl synthetase 0.0011 PF00186 Dihydrofolate reductase 0.0010 PF00018 SH3 domain 0.0009 PF00378 Enoyl-CoA hydratase/isomerase family 0.0009 PF01230 HIT domain 0.0008 PF05347 Complex 1 protein (LYR family), 0.0008 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0008 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0007 PF01833 IPT/TIG domain 0.0007 PF01403 Sema domain 0.0007 PF01437 Plexin repeat 0.0007 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0007 PF02779 Transketolase, pyrimidine binding domain 0.0007 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0006 PF00498 FHA domain 0.0006 PF01119 DNA mismatch repair protein, C-terminal domain 0.0006 PF12473 Kinesin protein 0.0006 PF12423 Kinesin protein 1B 0.0006 PF08676 MutL C terminal dimerisation domain 0.0006 PF00501 AMP-binding enzyme 0.0005 PF00794 PI3-kinase family, ras-binding domain 0.0005 PF00792 Phosphoinositide 3-kinase C2 0.0005 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0005 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0005 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0004 PF00225 Kinesin motor domain 0.0004 PF00400 WD domain, G-beta repeat 0.0004 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0004 PF00931 NB-ARC domain 0.0004 PF01808 AICARFT/IMPCHase bienzyme 0.0003 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0003 PF09326 Domain of unknown function (DUF1982), 0.0003 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0003 PF10276 Zinc-finger domain 0.0003 PF04116 Fatty acid hydroxylase superfamily 0.0003 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0003 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0003 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0003 PF02817 e3 binding domain 0.0003 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0003 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0003 PF01712 Deoxynucleoside kinase 0.0003 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0003 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0003 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0003 PF10531 SLBB domain 0.0003 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0003 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0003 PF09166 Biliverdin reductase, catalytic 0.0003 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0003 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0003 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0003 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0003 PF02466 Tim17/Tim22/Tim23 family 0.0003 PF06212 GRIM-19 protein 0.0003 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0003 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0003 PF00384 Molybdopterin oxidoreductase 0.0003 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0003 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0003 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0003 PF08040 MNLL subunit 0.0003 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0003 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0003 PF04716 ETC complex I subunit conserved region 0.0003 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0003 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0003 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0003 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0003 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0003 PF04800 ETC complex I subunit conserved region 0.0003 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0002 PF02173 pKID domain 0.0002 PF00962 Adenosine/AMP deaminase 0.0002 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0002 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0001 PF00042 Globin 0.0001 PF02780 Transketolase, C-terminal domain 0.0001 PF03435 Saccharopine dehydrogenase 0.0001 PF01064 Activin types I and II receptor domain 0.0001 PF08515 Transforming growth factor beta type I GS-motif 0.0001 PF00406 Adenylate kinase 0.0001 PF00170 bZIP transcription factor SUB4 >= 32 H 0.0526 PF08702 Fibrinogen alpha/beta chain family 0.0526 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0329 PF00273 Serum albumin family 0.0300 PF12160 Fibrinogen alpha C domain 0.0300 PF09396 Thrombin light chain 0.0228 PF00167 Fibroblast growth factor 0.0202 PF01459 Eukaryotic porin 0.0178 PF00079 Serpin (serine protease inhibitor), 0.0176 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0150 PF00051 Kringle domain 0.0146 PF00089 Trypsin 0.0090 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0089 PF02146 Sir2 family 0.0074 PF00024 PAN domain 0.0072 PF00405 Transferrin 0.0046 PF00854 POT family 0.0039 PF02806 Alpha amylase, C-terminal all-beta domain 0.0037 PF00690 Cation transporter/ATPase, N-terminus 0.0037 PF00689 Cation transporting ATPase, C-terminus 0.0036 PF00059 Lectin C-type domain 0.0033 PF00122 E1-E2 ATPase 0.0032 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0031 PF00128 Alpha amylase, catalytic domain 0.0025 PF00702 haloacid dehalogenase-like hydrolase 0.0023 PF00084 Sushi domain (SCR repeat), 0.0023 PF02793 Hormone receptor domain 0.0023 PF00002 7 transmembrane receptor (Secretin family), 0.0022 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0021 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0021 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0021 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0021 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0020 PF01055 Glycosyl hydrolases family 31 0.0020 PF00088 Trefoil (P-type), domain 0.0019 PF09193 Cholecystokinin A receptor, N-terminal 0.0018 PF04679 ATP dependent DNA ligase C terminal region 0.0018 PF01068 ATP dependent DNA ligase domain 0.0016 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0015 PF01370 NAD dependent epimerase/dehydratase family 0.0015 PF00578 AhpC/TSA family 0.0015 PF00188 Cysteine-rich secretory protein family 0.0015 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0014 PF01731 Arylesterase 0.0014 PF03414 Glycosyltransferase family 6 0.0014 PF01323 DSBA-like thioredoxin domain 0.0013 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0013 PF02260 FATC domain 0.0013 PF08771 Rapamycin binding domain 0.0013 PF02259 FAT domain 0.0013 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0012 PF02460 Patched family 0.0012 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0012 PF02180 Bcl-2 homology region 4 0.0011 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0011 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0011 PF07677 A-macroglobulin receptor 0.0011 PF07678 A-macroglobulin complement component 0.0011 PF01835 MG2 domain 0.0011 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0011 PF03489 Saposin-like type B, region 2 0.0010 PF00439 Bromodomain 0.0010 PF06617 M-phase inducer phosphatase 0.0010 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0010 PF03062 MBOAT family 0.0010 PF00581 Rhodanese-like domain 0.0009 PF03770 Inositol polyphosphate kinase 0.0009 PF03073 TspO/MBR family 0.0008 PF00169 PH domain 0.0008 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0008 PF01652 Eukaryotic initiation factor 4E 0.0007 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0007 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0007 PF03953 Tubulin C-terminal domain 0.0007 PF00091 Tubulin/FtsZ family, GTPase domain 0.0007 PF02233 NAD(P), transhydrogenase beta subunit 0.0006 PF02267 ADP-ribosyl cyclase 0.0006 PF08983 Domain of unknown function (DUF1856), 0.0005 PF00675 Insulinase (Peptidase family M16), 0.0005 PF00378 Enoyl-CoA hydratase/isomerase family 0.0005 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0005 PF05193 Peptidase M16 inactive domain 0.0005 PF00248 Aldo/keto reductase family 0.0005 PF00151 Lipase 0.0004 PF00171 Aldehyde dehydrogenase family 0.0004 PF00431 CUB domain 0.0004 PF00108 Thiolase, N-terminal domain 0.0004 PF00106 short chain dehydrogenase 0.0004 PF02803 Thiolase, C-terminal domain 0.0004 PF03360 Glycosyltransferase family 43 0.0003 PF01122 Eukaryotic cobalamin-binding protein 0.0003 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0003 PF07645 Calcium-binding EGF domain 0.0003 PF00406 Adenylate kinase 0.0003 PF00779 BTK motif 0.0003 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0003 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0002 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0002 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0002 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0002 PF01433 Peptidase family M1 0.0002 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.0002 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0002 PF02223 Thymidylate kinase 0.0001 PF01268 Formate--tetrahydrofolate ligase SUB422 C=S 0.0525 PF00091 Tubulin/FtsZ family, GTPase domain 0.0525 PF03953 Tubulin C-terminal domain 0.0076 PF07884 Vitamin K epoxide reductase family 0.0070 PF00018 SH3 domain 0.0062 PF00017 SH2 domain 0.0061 PF04679 ATP dependent DNA ligase C terminal region 0.0061 PF01068 ATP dependent DNA ligase domain 0.0060 PF01770 Reduced folate carrier 0.0058 PF08919 F-actin binding 0.0053 PF00102 Protein-tyrosine phosphatase 0.0050 PF00194 Eukaryotic-type carbonic anhydrase 0.0043 PF04263 Thiamin pyrophosphokinase, catalytic domain 0.0041 PF01404 Ephrin receptor ligand binding domain 0.0041 PF00536 SAM domain (Sterile alpha motif), 0.0033 PF00854 POT family 0.0029 PF00478 IMP dehydrogenase / GMP reductase domain 0.0029 PF02865 STAT protein, protein interaction domain 0.0029 PF01017 STAT protein, all-alpha domain 0.0029 PF02864 STAT protein, DNA binding domain 0.0027 PF02059 Interleukin-3 0.0027 PF00377 Prion/Doppel alpha-helical domain 0.0027 PF00656 Caspase domain 0.0027 PF00183 Hsp90 protein 0.0026 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0026 PF02394 Interleukin-1 propeptide 0.0026 PF00340 Interleukin-1 / 18 0.0023 PF00962 Adenosine/AMP deaminase 0.0019 PF01023 S-100/ICaBP type calcium binding domain 0.0018 PF00156 Phosphoribosyl transferase domain 0.0018 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0017 PF10397 Adenylosuccinate lyase C-terminus 0.0017 PF00020 TNFR/NGFR cysteine-rich region 0.0017 PF00069 Protein kinase domain 0.0017 PF03098 Animal haem peroxidase 0.0015 PF00619 Caspase recruitment domain 0.0015 PF00958 GMP synthase C terminal domain 0.0015 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0014 PF00341 Platelet-derived growth factor (PDGF), 0.0014 PF02525 Flavodoxin-like fold 0.0013 PF00305 Lipoxygenase 0.0012 PF09396 Thrombin light chain 0.0012 PF00040 Fibronectin type II domain 0.0012 PF00041 Fibronectin type III domain 0.0011 PF12497 Estrogen receptor beta 0.0011 PF00531 Death domain 0.0011 PF00206 Lyase 0.0010 PF02155 Glucocorticoid receptor 0.0009 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0007 PF00001 7 transmembrane receptor (rhodopsin family), 0.0006 PF00273 Serum albumin family 0.0006 PF00117 Glutamine amidotransferase class-I 0.0005 PF00709 Adenylosuccinate synthetase 0.0005 PF01477 PLAT/LH2 domain 0.0004 PF00230 Major intrinsic protein 0.0004 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0004 PF01425 Amidase 0.0004 PF00245 Alkaline phosphatase 0.0004 PF00310 Glutamine amidotransferases class-II 0.0004 PF00571 CBS domain 0.0003 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0003 PF01835 MG2 domain 0.0003 PF00690 Cation transporter/ATPase, N-terminus 0.0003 PF07678 A-macroglobulin complement component 0.0003 PF07677 A-macroglobulin receptor 0.0003 PF00689 Cation transporting ATPase, C-terminus 0.0003 PF01731 Arylesterase 0.0003 PF02254 TrkA-N domain 0.0003 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0003 PF00287 Sodium / potassium ATPase beta chain 0.0002 PF00122 E1-E2 ATPase 0.0001 PF08403 Amino acid permease N-terminal 0.0001 PF11857 Domain of unknown function (DUF3377), SUB827 OC1C(N)CCCC1 0.0524 PF00204 DNA gyrase B 0.0524 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0524 PF08070 DTHCT (NUC029), region 0.0209 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0188 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0188 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0120 PF01735 Lysophospholipase catalytic domain 0.0099 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0096 PF00989 PAS fold 0.0096 PF00576 HIUase/Transthyretin family 0.0086 PF00191 Annexin 0.0078 PF00102 Protein-tyrosine phosphatase 0.0077 PF00689 Cation transporting ATPase, C-terminus 0.0077 PF00690 Cation transporter/ATPase, N-terminus 0.0077 PF00027 Cyclic nucleotide-binding domain 0.0076 PF02155 Glucocorticoid receptor 0.0075 PF00194 Eukaryotic-type carbonic anhydrase 0.0075 PF03073 TspO/MBR family 0.0071 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0068 PF00122 E1-E2 ATPase 0.0066 PF02166 Androgen receptor 0.0065 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0065 PF00520 Ion transport protein 0.0059 PF00303 Thymidylate synthase 0.0058 PF00702 haloacid dehalogenase-like hydrolase 0.0057 PF03477 ATP cone domain 0.0057 PF02867 Ribonucleotide reductase, barrel domain 0.0057 PF00317 Ribonucleotide reductase, all-alpha domain 0.0057 PF00079 Serpin (serine protease inhibitor), 0.0056 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0049 PF00146 NADH dehydrogenase 0.0048 PF01180 Dihydroorotate dehydrogenase 0.0045 PF02214 K+ channel tetramerisation domain 0.0044 PF00168 C2 domain 0.0042 PF00757 Furin-like cysteine rich region 0.0042 PF01030 Receptor L domain 0.0037 PF08996 DNA Polymerase alpha zinc finger 0.0037 PF00136 DNA polymerase family B 0.0037 PF03104 DNA polymerase family B, exonuclease domain 0.0035 PF03098 Animal haem peroxidase 0.0034 PF00248 Aldo/keto reductase family 0.0033 PF00493 MCM2/3/5 family 0.0032 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0028 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0027 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0024 PF08063 PADR1 (NUC008), domain 0.0024 PF00028 Cadherin domain 0.0024 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0024 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0024 PF05406 WGR domain 0.0024 PF00533 BRCA1 C Terminus (BRCT), domain 0.0023 PF02460 Patched family 0.0023 PF00069 Protein kinase domain 0.0021 PF03062 MBOAT family 0.0020 PF00654 Voltage gated chloride channel 0.0019 PF06448 Domain of Unknown Function (DUF1081), 0.0019 PF12491 Apolipoprotein B100 C terminal 0.0017 PF02196 Raf-like Ras-binding domain 0.0016 PF00489 Interleukin-6/G-CSF/MGF family 0.0016 PF01731 Arylesterase 0.0015 PF00229 TNF(Tumour Necrosis Factor), family 0.0012 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0012 PF02180 Bcl-2 homology region 4 0.0011 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0009 PF01347 Lipoprotein amino terminal region 0.0008 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0007 PF00554 Rel homology domain (RHD), 0.0006 PF00058 Low-density lipoprotein receptor repeat class B 0.0005 PF00406 Adenylate kinase 0.0005 PF02864 STAT protein, DNA binding domain 0.0005 PF02865 STAT protein, protein interaction domain 0.0005 PF01391 Collagen triple helix repeat (20 copies), 0.0005 PF01017 STAT protein, all-alpha domain 0.0005 PF00042 Globin 0.0004 PF09396 Thrombin light chain 0.0004 PF01596 O-methyltransferase 0.0004 PF00432 Prenyltransferase and squalene oxidase repeat 0.0004 PF08403 Amino acid permease N-terminal 0.0003 PF01061 ABC-2 type transporter 0.0003 PF00071 Ras family 0.0003 PF00821 Phosphoenolpyruvate carboxykinase 0.0002 PF00656 Caspase domain 0.0002 PF01433 Peptidase family M1 0.0001 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0001 PF00341 Platelet-derived growth factor (PDGF), 0.0001 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region SUB580 O=C-C-C-C 0.0524 PF03098 Animal haem peroxidase 0.0402 PF00273 Serum albumin family 0.0340 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0340 PF00204 DNA gyrase B 0.0340 PF08070 DTHCT (NUC029), region 0.0279 PF01401 Angiotensin-converting enzyme 0.0218 PF00105 Zinc finger, C4 type (two domains), 0.0216 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0208 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0177 PF00191 Annexin 0.0173 PF00576 HIUase/Transthyretin family 0.0159 PF00102 Protein-tyrosine phosphatase 0.0149 PF02155 Glucocorticoid receptor 0.0129 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0129 PF03953 Tubulin C-terminal domain 0.0129 PF00091 Tubulin/FtsZ family, GTPase domain 0.0122 PF01063 Aminotransferase class IV 0.0115 PF00079 Serpin (serine protease inhibitor), 0.0075 PF00155 Aminotransferase class I and II 0.0060 PF01431 Peptidase family M13 0.0060 PF05649 Peptidase family M13 0.0055 PF00202 Aminotransferase class-III 0.0052 PF02159 Oestrogen receptor 0.0051 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0042 PF11825 Protein of unknown function (DUF3345), 0.0033 PF01842 ACT domain 0.0033 PF02798 Glutathione S-transferase, N-terminal domain 0.0031 PF00043 Glutathione S-transferase, C-terminal domain 0.0031 PF00464 Serine hydroxymethyltransferase 0.0030 PF00557 Metallopeptidase family M24 0.0029 PF00303 Thymidylate synthase 0.0028 PF02806 Alpha amylase, C-terminal all-beta domain 0.0027 PF01735 Lysophospholipase catalytic domain 0.0025 PF02166 Androgen receptor 0.0024 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0024 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0024 PF01268 Formate--tetrahydrofolate ligase 0.0017 PF01126 Heme oxygenase 0.0017 PF09396 Thrombin light chain 0.0016 PF00128 Alpha amylase, catalytic domain 0.0013 PF00733 Asparagine synthase 0.0013 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0013 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0013 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0010 PF00151 Lipase 0.0009 PF00822 PMP-22/EMP/MP20/Claudin family 0.0009 PF00024 PAN domain 0.0008 PF03414 Glycosyltransferase family 6 0.0008 PF00248 Aldo/keto reductase family 0.0006 PF00375 Sodium:dicarboxylate symporter family 0.0006 PF02574 Homocysteine S-methyltransferase 0.0005 PF00175 Oxidoreductase NAD-binding domain 0.0005 PF00039 Fibronectin type I domain 0.0005 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0005 PF01490 Transmembrane amino acid transporter protein 0.0005 PF00764 Arginosuccinate synthase 0.0005 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0005 PF00490 Delta-aminolevulinic acid dehydratase 0.0005 PF00291 Pyridoxal-phosphate dependent enzyme 0.0004 PF02898 Nitric oxide synthase, oxygenase domain 0.0004 PF07706 Aminotransferase ubiquitination site 0.0004 PF00255 Glutathione peroxidase 0.0003 PF00571 CBS domain 0.0003 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0003 PF00458 WHEP-TRS domain 0.0002 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0002 PF03171 2OG-Fe(II), oxygenase superfamily 0.0002 PF07648 Kazal-type serine protease inhibitor domain 0.0002 PF00667 FAD binding domain 0.0002 PF00258 Flavodoxin 0.0002 PF00266 Aminotransferase class-V 0.0002 PF04960 Glutaminase 0.0002 PF00071 Ras family 0.0001 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB804 OC1CC(O)CCC1 0.0522 PF08070 DTHCT (NUC029), region 0.0522 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0522 PF00204 DNA gyrase B 0.0235 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0140 PF00102 Protein-tyrosine phosphatase 0.0089 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0089 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0078 PF00576 HIUase/Transthyretin family 0.0073 PF00303 Thymidylate synthase 0.0069 PF01048 Phosphorylase superfamily 0.0067 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0057 PF01735 Lysophospholipase catalytic domain 0.0047 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0046 PF00989 PAS fold 0.0044 PF05406 WGR domain 0.0044 PF08063 PADR1 (NUC008), domain 0.0044 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0044 PF00533 BRCA1 C Terminus (BRCT), domain 0.0044 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0041 PF00191 Annexin 0.0040 PF00248 Aldo/keto reductase family 0.0040 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0040 PF01590 GAF domain 0.0038 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0037 PF00689 Cation transporting ATPase, C-terminus 0.0037 PF00690 Cation transporter/ATPase, N-terminus 0.0036 PF03073 TspO/MBR family 0.0036 PF00194 Eukaryotic-type carbonic anhydrase 0.0036 PF02155 Glucocorticoid receptor 0.0036 PF00027 Cyclic nucleotide-binding domain 0.0034 PF02525 Flavodoxin-like fold 0.0033 PF00821 Phosphoenolpyruvate carboxykinase 0.0032 PF03098 Animal haem peroxidase 0.0032 PF00122 E1-E2 ATPase 0.0031 PF01467 Cytidylyltransferase 0.0031 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0031 PF00520 Ion transport protein 0.0031 PF02166 Androgen receptor 0.0030 PF01268 Formate--tetrahydrofolate ligase 0.0029 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0029 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0028 PF01180 Dihydroorotate dehydrogenase 0.0028 PF00702 haloacid dehalogenase-like hydrolase 0.0027 PF01808 AICARFT/IMPCHase bienzyme 0.0027 PF02867 Ribonucleotide reductase, barrel domain 0.0027 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0027 PF00079 Serpin (serine protease inhibitor), 0.0027 PF00317 Ribonucleotide reductase, all-alpha domain 0.0027 PF03477 ATP cone domain 0.0026 PF00493 MCM2/3/5 family 0.0026 PF00107 Zinc-binding dehydrogenase 0.0026 PF00106 short chain dehydrogenase 0.0026 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0025 PF00071 Ras family 0.0025 PF08240 Alcohol dehydrogenase GroES-like domain 0.0023 PF00146 NADH dehydrogenase 0.0021 PF02214 K+ channel tetramerisation domain 0.0021 PF00858 Amiloride-sensitive sodium channel 0.0021 PF00168 C2 domain 0.0020 PF00757 Furin-like cysteine rich region 0.0020 PF01030 Receptor L domain 0.0019 PF01652 Eukaryotic initiation factor 4E 0.0019 PF00186 Dihydrofolate reductase 0.0018 PF03104 DNA polymerase family B, exonuclease domain 0.0018 PF02223 Thymidylate kinase 0.0018 PF00136 DNA polymerase family B 0.0018 PF08996 DNA Polymerase alpha zinc finger 0.0017 PF02142 MGS-like domain 0.0017 PF00183 Hsp90 protein 0.0017 PF01370 NAD dependent epimerase/dehydratase family 0.0016 PF00028 Cadherin domain 0.0015 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0015 PF00227 Proteasome subunit 0.0015 PF03024 Folate receptor family 0.0013 PF01731 Arylesterase 0.0013 PF00464 Serine hydroxymethyltransferase 0.0013 PF06448 Domain of Unknown Function (DUF1081), 0.0013 PF00551 Formyl transferase 0.0013 PF01571 Aminomethyltransferase folate-binding domain 0.0013 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0013 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0013 PF12491 Apolipoprotein B100 C terminal 0.0013 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0012 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0012 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0011 PF00025 ADP-ribosylation factor family 0.0011 PF02460 Patched family 0.0011 PF00654 Voltage gated chloride channel 0.0011 PF02267 ADP-ribosyl cyclase 0.0011 PF01575 MaoC like domain 0.0011 PF00171 Aldehyde dehydrogenase family 0.0011 PF02036 SCP-2 sterol transfer family 0.0011 PF00069 Protein kinase domain 0.0010 PF01061 ABC-2 type transporter 0.0010 PF03062 MBOAT family 0.0009 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0009 PF00305 Lipoxygenase 0.0009 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0009 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0009 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0009 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0008 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0008 PF02196 Raf-like Ras-binding domain 0.0008 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0008 PF00489 Interleukin-6/G-CSF/MGF family 0.0008 PF02233 NAD(P), transhydrogenase beta subunit 0.0007 PF08919 F-actin binding 0.0007 PF00229 TNF(Tumour Necrosis Factor), family 0.0007 PF01347 Lipoprotein amino terminal region 0.0006 PF00018 SH3 domain 0.0006 PF02219 Methylenetetrahydrofolate reductase 0.0006 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0006 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 0.0006 PF02180 Bcl-2 homology region 4 0.0006 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 0.0006 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0006 PF00822 PMP-22/EMP/MP20/Claudin family 0.0005 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0005 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0005 PF00999 Sodium/hydrogen exchanger family 0.0005 PF02059 Interleukin-3 0.0005 PF00017 SH2 domain 0.0005 PF03360 Glycosyltransferase family 43 0.0004 PF08403 Amino acid permease N-terminal 0.0004 PF00478 IMP dehydrogenase / GMP reductase domain 0.0004 PF00571 CBS domain 0.0004 PF01023 S-100/ICaBP type calcium binding domain 0.0004 PF00550 Phosphopantetheine attachment site 0.0004 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0003 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0003 PF03949 Malic enzyme, NAD binding domain 0.0003 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0003 PF00554 Rel homology domain (RHD), 0.0003 PF00406 Adenylate kinase 0.0003 PF00390 Malic enzyme, N-terminal domain 0.0003 PF00377 Prion/Doppel alpha-helical domain 0.0003 PF00586 AIR synthase related protein, N-terminal domain 0.0003 PF00058 Low-density lipoprotein receptor repeat class B 0.0003 PF00042 Globin 0.0003 PF07722 Peptidase C26 0.0003 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0003 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0003 PF10420 Cytokine interleukin-12p40 C-terminus 0.0003 PF02769 AIR synthase related protein, C-terminal domain 0.0003 PF02911 Formyl transferase, C-terminal domain 0.0002 PF00341 Platelet-derived growth factor (PDGF), 0.0002 PF01017 STAT protein, all-alpha domain 0.0002 PF00432 Prenyltransferase and squalene oxidase repeat 0.0002 PF00927 Transglutaminase family, C-terminal ig like domain 0.0002 PF00656 Caspase domain 0.0002 PF09396 Thrombin light chain 0.0002 PF01404 Ephrin receptor ligand binding domain 0.0002 PF00536 SAM domain (Sterile alpha motif), 0.0002 PF01227 GTP cyclohydrolase I 0.0002 PF00264 Common central domain of tyrosinase 0.0002 PF02865 STAT protein, protein interaction domain 0.0002 PF02864 STAT protein, DNA binding domain 0.0002 PF01596 O-methyltransferase 0.0002 PF00868 Transglutaminase family 0.0002 PF01391 Collagen triple helix repeat (20 copies), 0.0002 PF01841 Transglutaminase-like superfamily 0.0001 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0001 PF02394 Interleukin-1 propeptide 0.0001 PF03372 Endonuclease/Exonuclease/phosphatase family 0.0001 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0001 PF00340 Interleukin-1 / 18 0.0001 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0001 PF01433 Peptidase family M1 0.0001 PF00676 Dehydrogenase E1 component 0.0001 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain SUB703 O-C-C-C-C-C-N-C 0.0511 PF00204 DNA gyrase B 0.0511 PF08070 DTHCT (NUC029), region 0.0511 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0343 PF00186 Dihydrofolate reductase 0.0311 PF01048 Phosphorylase superfamily 0.0299 PF00001 7 transmembrane receptor (rhodopsin family), 0.0274 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0271 PF00069 Protein kinase domain 0.0201 PF00478 IMP dehydrogenase / GMP reductase domain 0.0171 PF02798 Glutathione S-transferase, N-terminal domain 0.0167 PF00043 Glutathione S-transferase, C-terminal domain 0.0148 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0133 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0119 PF08240 Alcohol dehydrogenase GroES-like domain 0.0116 PF00571 CBS domain 0.0105 PF00107 Zinc-binding dehydrogenase 0.0101 PF00255 Glutathione peroxidase 0.0093 PF00962 Adenosine/AMP deaminase 0.0092 PF00017 SH2 domain 0.0090 PF02223 Thymidylate kinase 0.0089 PF00018 SH3 domain 0.0081 PF05649 Peptidase family M13 0.0081 PF01431 Peptidase family M13 0.0078 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0078 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0071 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0071 PF00106 short chain dehydrogenase 0.0064 PF01590 GAF domain 0.0057 PF01124 MAPEG family 0.0056 PF08919 F-actin binding 0.0055 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0050 PF03953 Tubulin C-terminal domain 0.0050 PF00091 Tubulin/FtsZ family, GTPase domain 0.0049 PF01401 Angiotensin-converting enzyme 0.0046 PF09396 Thrombin light chain 0.0045 PF03199 Eukaryotic glutathione synthase 0.0045 PF00005 ABC transporter 0.0045 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0042 PF00858 Amiloride-sensitive sodium channel 0.0037 PF01467 Cytidylyltransferase 0.0036 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0036 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0036 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0034 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0034 PF01323 DSBA-like thioredoxin domain 0.0031 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0031 PF00656 Caspase domain 0.0030 PF08983 Domain of unknown function (DUF1856), 0.0029 PF00303 Thymidylate synthase 0.0029 PF00171 Aldehyde dehydrogenase family 0.0028 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0027 PF00156 Phosphoribosyl transferase domain 0.0025 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0025 PF00462 Glutaredoxin 0.0025 PF03073 TspO/MBR family 0.0023 PF07722 Peptidase C26 0.0022 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0022 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0020 PF01406 tRNA synthetases class I (C), catalytic domain 0.0020 PF05995 Cysteine dioxygenase type I 0.0019 PF01019 Gamma-glutamyltranspeptidase 0.0019 PF00756 Putative esterase 0.0017 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0017 PF00619 Caspase recruitment domain 0.0017 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0017 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0016 PF03074 Glutamate-cysteine ligase 0.0011 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0011 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0011 PF00439 Bromodomain 0.0010 PF06617 M-phase inducer phosphatase 0.0010 PF00581 Rhodanese-like domain 0.0009 PF03002 Somatostatin/Cortistatin family 0.0009 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0009 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0008 PF01687 Riboflavin kinase 0.0008 PF00085 Thioredoxin 0.0007 PF00778 DIX domain 0.0007 PF00806 Pumilio-family RNA binding repeat 0.0007 PF00265 Thymidine kinase 0.0007 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0007 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0007 PF00822 PMP-22/EMP/MP20/Claudin family 0.0007 PF08833 Axin beta-catenin binding domain 0.0006 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0006 PF01061 ABC-2 type transporter 0.0006 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0005 PF00931 NB-ARC domain 0.0005 PF02267 ADP-ribosyl cyclase 0.0005 PF00400 WD domain, G-beta repeat 0.0005 PF00342 Phosphoglucose isomerase 0.0004 PF00002 7 transmembrane receptor (Secretin family), 0.0004 PF00664 ABC transporter transmembrane region 0.0004 PF02793 Hormone receptor domain 0.0003 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0003 PF01268 Formate--tetrahydrofolate ligase 0.0003 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0002 PF10420 Cytokine interleukin-12p40 C-terminus 0.0002 PF02769 AIR synthase related protein, C-terminal domain 0.0002 PF00586 AIR synthase related protein, N-terminal domain 0.0001 PF00108 Thiolase, N-terminal domain 0.0001 PF01575 MaoC like domain 0.0001 PF00045 Hemopexin 0.0001 PF02036 SCP-2 sterol transfer family 0.0001 PF02803 Thiolase, C-terminal domain 0.0001 PF01471 Putative peptidoglycan binding domain SUB598 O=C-C-C:C 0.0505 PF03098 Animal haem peroxidase 0.0504 PF00204 DNA gyrase B 0.0504 PF08070 DTHCT (NUC029), region 0.0504 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0286 PF00191 Annexin 0.0251 PF02155 Glucocorticoid receptor 0.0236 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0213 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0211 PF00105 Zinc finger, C4 type (two domains), 0.0207 PF00273 Serum albumin family 0.0180 PF00102 Protein-tyrosine phosphatase 0.0142 PF07884 Vitamin K epoxide reductase family 0.0095 PF01735 Lysophospholipase catalytic domain 0.0089 PF00005 ABC transporter 0.0084 PF06512 Sodium ion transport-associated 0.0080 PF02161 Progesterone receptor 0.0071 PF02525 Flavodoxin-like fold 0.0067 PF00576 HIUase/Transthyretin family 0.0066 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0065 PF00079 Serpin (serine protease inhibitor), 0.0064 PF01268 Formate--tetrahydrofolate ligase 0.0063 PF00464 Serine hydroxymethyltransferase 0.0062 PF02166 Androgen receptor 0.0061 PF00664 ABC transporter transmembrane region 0.0059 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0059 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0058 PF09396 Thrombin light chain 0.0050 PF00051 Kringle domain 0.0050 PF00089 Trypsin 0.0045 PF00554 Rel homology domain (RHD), 0.0043 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0043 PF05406 WGR domain 0.0043 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0043 PF00533 BRCA1 C Terminus (BRCT), domain 0.0043 PF08063 PADR1 (NUC008), domain 0.0038 PF01061 ABC-2 type transporter 0.0037 PF00551 Formyl transferase 0.0037 PF08403 Amino acid permease N-terminal 0.0034 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0033 PF11825 Protein of unknown function (DUF3345), 0.0032 PF00017 SH2 domain 0.0029 PF01571 Aminomethyltransferase folate-binding domain 0.0029 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0020 PF00018 SH3 domain 0.0019 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A), domain 0.0019 PF02843 Phosphoribosylglycinamide synthetase, C domain 0.0019 PF02844 Phosphoribosylglycinamide synthetase, N domain 0.0017 PF02219 Methylenetetrahydrofolate reductase 0.0016 PF00531 Death domain 0.0015 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0011 PF00229 TNF(Tumour Necrosis Factor), family 0.0010 PF00183 Hsp90 protein 0.0008 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0006 PF01467 Cytidylyltransferase 0.0005 PF00343 Carbohydrate phosphorylase 0.0005 PF02911 Formyl transferase, C-terminal domain 0.0005 PF03024 Folate receptor family 0.0003 PF00248 Aldo/keto reductase family 0.0001 PF01180 Dihydroorotate dehydrogenase SUB377 C(~N)(:C) 0.0503 PF03073 TspO/MBR family 0.0501 PF00194 Eukaryotic-type carbonic anhydrase 0.0390 PF00186 Dihydrofolate reductase 0.0281 PF00069 Protein kinase domain 0.0216 PF01048 Phosphorylase superfamily 0.0205 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0203 PF00001 7 transmembrane receptor (rhodopsin family), 0.0194 PF08403 Amino acid permease N-terminal 0.0173 PF00204 DNA gyrase B 0.0173 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0173 PF08070 DTHCT (NUC029), region 0.0148 PF06512 Sodium ion transport-associated 0.0118 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0118 PF02254 TrkA-N domain 0.0101 PF00005 ABC transporter 0.0095 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0076 PF00478 IMP dehydrogenase / GMP reductase domain 0.0069 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0067 PF01126 Heme oxygenase 0.0058 PF00962 Adenosine/AMP deaminase 0.0053 PF01061 ABC-2 type transporter 0.0053 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0051 PF00017 SH2 domain 0.0049 PF00520 Ion transport protein 0.0046 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0046 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0045 PF00018 SH3 domain 0.0042 PF01590 GAF domain 0.0039 PF00664 ABC transporter transmembrane region 0.0033 PF00571 CBS domain 0.0031 PF00042 Globin 0.0027 PF00102 Protein-tyrosine phosphatase 0.0026 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0026 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0022 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0018 PF00156 Phosphoribosyl transferase domain 0.0016 PF00464 Serine hydroxymethyltransferase 0.0013 PF08919 F-actin binding 0.0012 PF00858 Amiloride-sensitive sodium channel 0.0011 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0011 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0010 PF01268 Formate--tetrahydrofolate ligase 0.0008 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB696 O=C-C-C-C-C-N 0.0501 PF02798 Glutathione S-transferase, N-terminal domain 0.0490 PF00043 Glutathione S-transferase, C-terminal domain 0.0297 PF00255 Glutathione peroxidase 0.0239 PF05649 Peptidase family M13 0.0239 PF01431 Peptidase family M13 0.0208 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0168 PF01124 MAPEG family 0.0156 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0148 PF03953 Tubulin C-terminal domain 0.0148 PF00091 Tubulin/FtsZ family, GTPase domain 0.0144 PF01401 Angiotensin-converting enzyme 0.0136 PF09396 Thrombin light chain 0.0132 PF03199 Eukaryotic glutathione synthase 0.0132 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0101 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0100 PF01323 DSBA-like thioredoxin domain 0.0090 PF00656 Caspase domain 0.0088 PF08983 Domain of unknown function (DUF1856), 0.0084 PF00303 Thymidylate synthase 0.0078 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0073 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0072 PF00462 Glutaredoxin 0.0068 PF07722 Peptidase C26 0.0060 PF01406 tRNA synthetases class I (C), catalytic domain 0.0058 PF05995 Cysteine dioxygenase type I 0.0057 PF01019 Gamma-glutamyltranspeptidase 0.0057 PF00756 Putative esterase 0.0051 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0051 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0049 PF00619 Caspase recruitment domain 0.0048 PF03074 Glutamate-cysteine ligase 0.0033 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0033 PF00439 Bromodomain 0.0033 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0029 PF00581 Rhodanese-like domain 0.0029 PF06617 M-phase inducer phosphatase 0.0026 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0026 PF03002 Somatostatin/Cortistatin family 0.0025 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0022 PF08833 Axin beta-catenin binding domain 0.0022 PF00806 Pumilio-family RNA binding repeat 0.0022 PF00778 DIX domain 0.0022 PF00085 Thioredoxin 0.0021 PF00822 PMP-22/EMP/MP20/Claudin family 0.0019 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0019 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0019 PF00265 Thymidine kinase 0.0016 PF00931 NB-ARC domain 0.0016 PF00400 WD domain, G-beta repeat 0.0016 PF00342 Phosphoglucose isomerase 0.0012 PF00002 7 transmembrane receptor (Secretin family), 0.0012 PF02793 Hormone receptor domain 0.0009 PF01268 Formate--tetrahydrofolate ligase 0.0005 PF00586 AIR synthase related protein, N-terminal domain 0.0005 PF02769 AIR synthase related protein, C-terminal domain 0.0005 PF10420 Cytokine interleukin-12p40 C-terminus 0.0004 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0004 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0003 PF01471 Putative peptidoglycan binding domain 0.0003 PF00108 Thiolase, N-terminal domain 0.0003 PF02803 Thiolase, C-terminal domain 0.0003 PF00045 Hemopexin 0.0001 PF00551 Formyl transferase SUB505 N:C:N-C 0.0499 PF00186 Dihydrofolate reductase 0.0266 PF00069 Protein kinase domain 0.0223 PF00478 IMP dehydrogenase / GMP reductase domain 0.0196 PF08240 Alcohol dehydrogenase GroES-like domain 0.0175 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0173 PF00107 Zinc-binding dehydrogenase 0.0170 PF01048 Phosphorylase superfamily 0.0161 PF00106 short chain dehydrogenase 0.0147 PF00571 CBS domain 0.0111 PF00962 Adenosine/AMP deaminase 0.0107 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0107 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0107 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0107 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0107 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0090 PF00171 Aldehyde dehydrogenase family 0.0072 PF00018 SH3 domain 0.0071 PF00248 Aldo/keto reductase family 0.0068 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0068 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0065 PF02223 Thymidylate kinase 0.0059 PF00156 Phosphoribosyl transferase domain 0.0053 PF01122 Eukaryotic cobalamin-binding protein 0.0052 PF00017 SH2 domain 0.0050 PF00501 AMP-binding enzyme 0.0045 PF08919 F-actin binding 0.0040 PF01467 Cytidylyltransferase 0.0039 PF02310 B12 binding domain 0.0037 PF01923 Cobalamin adenosyltransferase 0.0037 PF03308 ArgK protein 0.0037 PF01642 Methylmalonyl-CoA mutase 0.0031 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0031 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0031 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0030 PF00225 Kinesin motor domain 0.0027 PF01575 MaoC like domain 0.0027 PF00970 Oxidoreductase FAD-binding domain 0.0027 PF01230 HIT domain 0.0027 PF02036 SCP-2 sterol transfer family 0.0026 PF12423 Kinesin protein 1B 0.0026 PF08676 MutL C terminal dimerisation domain 0.0026 PF03949 Malic enzyme, NAD binding domain 0.0026 PF12473 Kinesin protein 0.0026 PF00498 FHA domain 0.0026 PF01119 DNA mismatch repair protein, C-terminal domain 0.0026 PF00390 Malic enzyme, N-terminal domain 0.0025 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0025 PF03104 DNA polymerase family B, exonuclease domain 0.0025 PF08996 DNA Polymerase alpha zinc finger 0.0025 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0025 PF00136 DNA polymerase family B 0.0024 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0024 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0022 PF02233 NAD(P), transhydrogenase beta subunit 0.0021 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0021 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0021 PF00400 WD domain, G-beta repeat 0.0021 PF00931 NB-ARC domain 0.0019 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0018 PF02607 B12 binding domain 0.0018 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0018 PF00809 Pterin binding enzyme 0.0018 PF03770 Inositol polyphosphate kinase 0.0017 PF00431 CUB domain 0.0017 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0017 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0016 PF00175 Oxidoreductase NAD-binding domain 0.0016 PF02867 Ribonucleotide reductase, barrel domain 0.0016 PF00667 FAD binding domain 0.0016 PF03477 ATP cone domain 0.0016 PF00258 Flavodoxin 0.0016 PF00317 Ribonucleotide reductase, all-alpha domain 0.0015 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0015 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0011 PF07645 Calcium-binding EGF domain 0.0009 PF01268 Formate--tetrahydrofolate ligase 0.0009 PF02574 Homocysteine S-methyltransferase 0.0007 PF00858 Amiloride-sensitive sodium channel 0.0007 PF01030 Receptor L domain 0.0007 PF00757 Furin-like cysteine rich region 0.0006 PF00378 Enoyl-CoA hydratase/isomerase family 0.0006 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0006 PF00676 Dehydrogenase E1 component 0.0005 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0005 PF08515 Transforming growth factor beta type I GS-motif 0.0005 PF01064 Activin types I and II receptor domain 0.0004 PF01126 Heme oxygenase 0.0003 PF02267 ADP-ribosyl cyclase 0.0003 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0002 PF00005 ABC transporter 0.0002 PF01652 Eukaryotic initiation factor 4E 0.0002 PF02525 Flavodoxin-like fold 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF05347 Complex 1 protein (LYR family), 0.0001 PF01833 IPT/TIG domain 0.0001 PF01437 Plexin repeat 0.0001 PF01687 Riboflavin kinase 0.0001 PF01403 Sema domain 0.0001 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0001 PF00348 Polyprenyl synthetase 0.0001 PF02779 Transketolase, pyrimidine binding domain 0.0001 PF00057 Low-density lipoprotein receptor domain class A 0.0001 PF00058 Low-density lipoprotein receptor repeat class B 0.0001 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF01208 Uroporphyrinogen decarboxylase (URO-D), SUB608 N-C-C-C:C 0.0498 PF00001 7 transmembrane receptor (rhodopsin family), 0.0133 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0119 PF03073 TspO/MBR family 0.0111 PF00209 Sodium:neurotransmitter symporter family 0.0092 PF06512 Sodium ion transport-associated 0.0069 PF00005 ABC transporter 0.0060 PF00520 Ion transport protein 0.0058 PF01401 Angiotensin-converting enzyme 0.0057 PF00664 ABC transporter transmembrane region 0.0056 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0056 PF08070 DTHCT (NUC029), region 0.0056 PF00204 DNA gyrase B 0.0055 PF00989 PAS fold 0.0047 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0046 PF03098 Animal haem peroxidase 0.0045 PF00027 Cyclic nucleotide-binding domain 0.0045 PF00186 Dihydrofolate reductase 0.0044 PF01593 Flavin containing amine oxidoreductase 0.0043 PF00069 Protein kinase domain 0.0035 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0031 PF00194 Eukaryotic-type carbonic anhydrase 0.0029 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0029 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0024 PF01048 Phosphorylase superfamily 0.0017 PF00102 Protein-tyrosine phosphatase 0.0016 PF09396 Thrombin light chain 0.0013 PF03953 Tubulin C-terminal domain 0.0013 PF00091 Tubulin/FtsZ family, GTPase domain 0.0013 PF00017 SH2 domain 0.0010 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0010 PF08983 Domain of unknown function (DUF1856), 0.0010 PF01061 ABC-2 type transporter 0.0010 PF00576 HIUase/Transthyretin family 0.0010 PF02180 Bcl-2 homology region 4 0.0007 PF01007 Inward rectifier potassium channel 0.0006 PF08403 Amino acid permease N-terminal 0.0005 PF00018 SH3 domain 0.0005 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0004 PF05649 Peptidase family M13 0.0004 PF01431 Peptidase family M13 0.0004 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0004 PF08491 Squalene epoxidase 0.0004 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0003 PF07884 Vitamin K epoxide reductase family 0.0003 PF08919 F-actin binding 0.0003 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0002 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0002 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0001 PF02223 Thymidylate kinase 0.0001 PF12497 Estrogen receptor beta 0.0001 PF00822 PMP-22/EMP/MP20/Claudin family 0.0001 PF00962 Adenosine/AMP deaminase 0.0001 PF01467 Cytidylyltransferase SUB529 [#1]-N-C-[#1] 0.0493 PF02798 Glutathione S-transferase, N-terminal domain 0.0482 PF00043 Glutathione S-transferase, C-terminal domain 0.0292 PF00255 Glutathione peroxidase 0.0235 PF05649 Peptidase family M13 0.0235 PF01431 Peptidase family M13 0.0205 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0165 PF01124 MAPEG family 0.0153 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0145 PF03953 Tubulin C-terminal domain 0.0145 PF00091 Tubulin/FtsZ family, GTPase domain 0.0141 PF01401 Angiotensin-converting enzyme 0.0134 PF09396 Thrombin light chain 0.0129 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0129 PF03199 Eukaryotic glutathione synthase 0.0099 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0098 PF01323 DSBA-like thioredoxin domain 0.0089 PF00656 Caspase domain 0.0087 PF08983 Domain of unknown function (DUF1856), 0.0082 PF00303 Thymidylate synthase 0.0076 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0072 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0071 PF00462 Glutaredoxin 0.0067 PF07722 Peptidase C26 0.0059 PF01406 tRNA synthetases class I (C), catalytic domain 0.0057 PF05995 Cysteine dioxygenase type I 0.0056 PF01019 Gamma-glutamyltranspeptidase 0.0056 PF00756 Putative esterase 0.0050 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0050 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0048 PF00619 Caspase recruitment domain 0.0047 PF03074 Glutamate-cysteine ligase 0.0033 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0032 PF00439 Bromodomain 0.0032 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0029 PF00581 Rhodanese-like domain 0.0029 PF06617 M-phase inducer phosphatase 0.0026 PF03002 Somatostatin/Cortistatin family 0.0025 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0025 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0022 PF00085 Thioredoxin 0.0021 PF00778 DIX domain 0.0021 PF00806 Pumilio-family RNA binding repeat 0.0021 PF00822 PMP-22/EMP/MP20/Claudin family 0.0021 PF08833 Axin beta-catenin binding domain 0.0019 PF00265 Thymidine kinase 0.0018 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0018 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0016 PF00342 Phosphoglucose isomerase 0.0015 PF00931 NB-ARC domain 0.0015 PF00400 WD domain, G-beta repeat 0.0011 PF00002 7 transmembrane receptor (Secretin family), 0.0011 PF02793 Hormone receptor domain 0.0008 PF01268 Formate--tetrahydrofolate ligase 0.0005 PF02769 AIR synthase related protein, C-terminal domain 0.0005 PF00586 AIR synthase related protein, N-terminal domain 0.0005 PF10420 Cytokine interleukin-12p40 C-terminus 0.0004 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0004 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0003 PF00108 Thiolase, N-terminal domain 0.0003 PF00045 Hemopexin 0.0003 PF01471 Putative peptidoglycan binding domain 0.0003 PF02803 Thiolase, C-terminal domain 0.0001 PF00551 Formyl transferase SUB116 >= 1 any ring size 3 0.0479 PF08070 DTHCT (NUC029), region 0.0479 PF00204 DNA gyrase B 0.0479 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0191 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0172 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0172 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0110 PF01735 Lysophospholipase catalytic domain 0.0091 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0088 PF00989 PAS fold 0.0087 PF00576 HIUase/Transthyretin family 0.0078 PF00191 Annexin 0.0071 PF00689 Cation transporting ATPase, C-terminus 0.0071 PF00690 Cation transporter/ATPase, N-terminus 0.0071 PF00102 Protein-tyrosine phosphatase 0.0070 PF00027 Cyclic nucleotide-binding domain 0.0069 PF00194 Eukaryotic-type carbonic anhydrase 0.0069 PF02155 Glucocorticoid receptor 0.0068 PF03073 TspO/MBR family 0.0065 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0062 PF00122 E1-E2 ATPase 0.0060 PF02166 Androgen receptor 0.0059 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0059 PF00520 Ion transport protein 0.0054 PF00303 Thymidylate synthase 0.0053 PF00702 haloacid dehalogenase-like hydrolase 0.0052 PF00079 Serpin (serine protease inhibitor), 0.0052 PF00317 Ribonucleotide reductase, all-alpha domain 0.0052 PF03477 ATP cone domain 0.0052 PF02867 Ribonucleotide reductase, barrel domain 0.0051 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0045 PF00146 NADH dehydrogenase 0.0044 PF01180 Dihydroorotate dehydrogenase 0.0041 PF02214 K+ channel tetramerisation domain 0.0040 PF00168 C2 domain 0.0038 PF01030 Receptor L domain 0.0038 PF00757 Furin-like cysteine rich region 0.0034 PF03104 DNA polymerase family B, exonuclease domain 0.0034 PF08996 DNA Polymerase alpha zinc finger 0.0034 PF00136 DNA polymerase family B 0.0032 PF03098 Animal haem peroxidase 0.0031 PF00248 Aldo/keto reductase family 0.0030 PF00493 MCM2/3/5 family 0.0029 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0026 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0025 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0022 PF00028 Cadherin domain 0.0022 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0022 PF00533 BRCA1 C Terminus (BRCT), domain 0.0022 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0022 PF05406 WGR domain 0.0022 PF08063 PADR1 (NUC008), domain 0.0021 PF02460 Patched family 0.0021 PF00069 Protein kinase domain 0.0019 PF00654 Voltage gated chloride channel 0.0019 PF03062 MBOAT family 0.0017 PF06448 Domain of Unknown Function (DUF1081), 0.0017 PF12491 Apolipoprotein B100 C terminal 0.0015 PF00489 Interleukin-6/G-CSF/MGF family 0.0015 PF02196 Raf-like Ras-binding domain 0.0014 PF01731 Arylesterase 0.0014 PF00229 TNF(Tumour Necrosis Factor), family 0.0011 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0011 PF02180 Bcl-2 homology region 4 0.0010 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0008 PF01347 Lipoprotein amino terminal region 0.0007 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0006 PF00554 Rel homology domain (RHD), 0.0005 PF00058 Low-density lipoprotein receptor repeat class B 0.0005 PF00406 Adenylate kinase 0.0005 PF00042 Globin 0.0004 PF08403 Amino acid permease N-terminal 0.0004 PF01391 Collagen triple helix repeat (20 copies), 0.0004 PF02864 STAT protein, DNA binding domain 0.0004 PF02865 STAT protein, protein interaction domain 0.0004 PF01017 STAT protein, all-alpha domain 0.0004 PF09396 Thrombin light chain 0.0004 PF00432 Prenyltransferase and squalene oxidase repeat 0.0003 PF01596 O-methyltransferase 0.0003 PF01061 ABC-2 type transporter 0.0003 PF00821 Phosphoenolpyruvate carboxykinase 0.0003 PF00071 Ras family 0.0002 PF01433 Peptidase family M1 0.0002 PF00656 Caspase domain 0.0001 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0001 PF00341 Platelet-derived growth factor (PDGF), 0.0001 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region SUB17 >= 4 N 0.0468 PF00186 Dihydrofolate reductase 0.0329 PF01048 Phosphorylase superfamily 0.0256 PF00478 IMP dehydrogenase / GMP reductase domain 0.0248 PF00069 Protein kinase domain 0.0194 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0146 PF00571 CBS domain 0.0133 PF00962 Adenosine/AMP deaminase 0.0127 PF08070 DTHCT (NUC029), region 0.0127 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0127 PF00204 DNA gyrase B 0.0121 PF03073 TspO/MBR family 0.0098 PF08240 Alcohol dehydrogenase GroES-like domain 0.0088 PF01590 GAF domain 0.0087 PF00106 short chain dehydrogenase 0.0086 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0086 PF00156 Phosphoribosyl transferase domain 0.0080 PF00107 Zinc-binding dehydrogenase 0.0074 PF00001 7 transmembrane receptor (rhodopsin family), 0.0073 PF00018 SH3 domain 0.0069 PF00017 SH2 domain 0.0069 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0069 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0068 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0063 PF01122 Eukaryotic cobalamin-binding protein 0.0058 PF08919 F-actin binding 0.0053 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0053 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0053 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0050 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0045 PF02310 B12 binding domain 0.0043 PF01923 Cobalamin adenosyltransferase 0.0043 PF03308 ArgK protein 0.0043 PF01642 Methylmalonyl-CoA mutase 0.0042 PF00858 Amiloride-sensitive sodium channel 0.0040 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0039 PF00171 Aldehyde dehydrogenase family 0.0031 PF02223 Thymidylate kinase 0.0029 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0029 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0028 PF01030 Receptor L domain 0.0028 PF09396 Thrombin light chain 0.0028 PF00757 Furin-like cysteine rich region 0.0027 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0027 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0025 PF01268 Formate--tetrahydrofolate ligase 0.0020 PF00809 Pterin binding enzyme 0.0020 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0020 PF00431 CUB domain 0.0020 PF02607 B12 binding domain 0.0020 PF01687 Riboflavin kinase 0.0019 PF00175 Oxidoreductase NAD-binding domain 0.0019 PF00667 FAD binding domain 0.0019 PF00258 Flavodoxin 0.0015 PF01467 Cytidylyltransferase 0.0015 PF00821 Phosphoenolpyruvate carboxykinase 0.0013 PF07645 Calcium-binding EGF domain 0.0013 PF00501 AMP-binding enzyme 0.0011 PF00005 ABC transporter 0.0011 PF02574 Homocysteine S-methyltransferase 0.0010 PF01808 AICARFT/IMPCHase bienzyme 0.0009 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0009 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0008 PF02267 ADP-ribosyl cyclase 0.0008 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0005 PF00970 Oxidoreductase FAD-binding domain 0.0005 PF00317 Ribonucleotide reductase, all-alpha domain 0.0005 PF03477 ATP cone domain 0.0005 PF02867 Ribonucleotide reductase, barrel domain 0.0004 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0004 PF01575 MaoC like domain 0.0004 PF02036 SCP-2 sterol transfer family 0.0004 PF01652 Eukaryotic initiation factor 4E 0.0004 PF01126 Heme oxygenase 0.0003 PF08676 MutL C terminal dimerisation domain 0.0003 PF00248 Aldo/keto reductase family 0.0003 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF00498 FHA domain 0.0003 PF12423 Kinesin protein 1B 0.0003 PF12473 Kinesin protein 0.0003 PF01119 DNA mismatch repair protein, C-terminal domain 0.0002 PF03104 DNA polymerase family B, exonuclease domain 0.0002 PF00136 DNA polymerase family B 0.0002 PF02233 NAD(P), transhydrogenase beta subunit 0.0002 PF08996 DNA Polymerase alpha zinc finger 0.0002 PF00390 Malic enzyme, N-terminal domain 0.0002 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0002 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0002 PF10397 Adenylosuccinate lyase C-terminus 0.0002 PF00057 Low-density lipoprotein receptor domain class A 0.0002 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0002 PF00058 Low-density lipoprotein receptor repeat class B 0.0002 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0002 PF01230 HIT domain 0.0002 PF00536 SAM domain (Sterile alpha motif), 0.0002 PF03949 Malic enzyme, NAD binding domain 0.0002 PF01404 Ephrin receptor ligand binding domain 0.0002 PF01061 ABC-2 type transporter 0.0002 PF03770 Inositol polyphosphate kinase 0.0002 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF01833 IPT/TIG domain 0.0001 PF02779 Transketolase, pyrimidine binding domain 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF05347 Complex 1 protein (LYR family), 0.0001 PF00348 Polyprenyl synthetase 0.0001 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0001 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0001 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0001 PF01403 Sema domain 0.0001 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0001 PF00794 PI3-kinase family, ras-binding domain 0.0001 PF01437 Plexin repeat 0.0001 PF00792 Phosphoinositide 3-kinase C2 0.0001 PF00676 Dehydrogenase E1 component 0.0001 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0001 PF00664 ABC transporter transmembrane region 0.0001 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0001 PF00378 Enoyl-CoA hydratase/isomerase family 0.0001 PF02525 Flavodoxin-like fold 0.0001 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0001 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit SUB656 O-C-C-C:C 0.0467 PF02159 Oestrogen receptor 0.0261 PF00001 7 transmembrane receptor (rhodopsin family), 0.0201 PF00105 Zinc finger, C4 type (two domains), 0.0199 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0199 PF00204 DNA gyrase B 0.0199 PF08070 DTHCT (NUC029), region 0.0196 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0106 PF00576 HIUase/Transthyretin family 0.0100 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0093 PF12497 Estrogen receptor beta 0.0072 PF00989 PAS fold 0.0068 PF00976 Corticotropin ACTH domain 0.0068 PF08384 Pro-opiomelanocortin, N-terminal region 0.0068 PF08035 Opioids neuropeptide 0.0064 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0063 PF00102 Protein-tyrosine phosphatase 0.0058 PF00027 Cyclic nucleotide-binding domain 0.0056 PF00005 ABC transporter 0.0056 PF00664 ABC transporter transmembrane region 0.0048 PF11825 Protein of unknown function (DUF3345), 0.0036 PF00643 B-box zinc finger 0.0036 PF01596 O-methyltransferase 0.0027 PF01477 PLAT/LH2 domain 0.0025 PF00305 Lipoxygenase 0.0023 PF02394 Interleukin-1 propeptide 0.0023 PF03062 MBOAT family 0.0023 PF00340 Interleukin-1 / 18 0.0020 PF08983 Domain of unknown function (DUF1856), 0.0018 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0014 PF00656 Caspase domain 0.0013 PF04622 ERG2 and Sigma1 receptor like protein 0.0013 PF00183 Hsp90 protein 0.0013 PF00135 Carboxylesterase 0.0011 PF00918 Gastrin/cholecystokinin family 0.0011 PF01160 Vertebrate endogenous opioids neuropeptide 0.0009 PF00650 CRAL/TRIO domain 0.0009 PF03765 CRAL/TRIO, N-terminus 0.0009 PF03098 Animal haem peroxidase 0.0009 PF01588 Putative tRNA binding domain 0.0008 PF01180 Dihydroorotate dehydrogenase 0.0008 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0008 PF08441 Integrin alpha 0.0007 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0007 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0007 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0007 PF00266 Aminotransferase class-V 0.0007 PF02180 Bcl-2 homology region 4 0.0007 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0007 PF00377 Prion/Doppel alpha-helical domain 0.0007 PF02460 Patched family 0.0007 PF08377 MAP2/Tau projection domain 0.0006 PF06327 Domain of Unknown Function (DUF1053), 0.0006 PF00357 Integrin alpha cytoplasmic region 0.0006 PF00884 Sulfatase 0.0006 PF00625 Guanylate kinase 0.0006 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0006 PF08674 Acetylcholinesterase tetramerisation domain 0.0005 PF07885 Ion channel 0.0004 PF00068 Phospholipase A2 0.0004 PF00186 Dihydrofolate reductase 0.0004 PF09396 Thrombin light chain 0.0004 PF07884 Vitamin K epoxide reductase family 0.0003 PF00229 TNF(Tumour Necrosis Factor), family 0.0003 PF08763 Voltage gated calcium channel IQ domain 0.0003 PF02025 Interleukin 5 0.0003 PF00094 von Willebrand factor type D domain 0.0003 PF00341 Platelet-derived growth factor (PDGF), 0.0003 PF02793 Hormone receptor domain 0.0003 PF00702 haloacid dehalogenase-like hydrolase 0.0003 PF09193 Cholecystokinin A receptor, N-terminal 0.0003 PF02201 SWIB/MDM2 domain 0.0003 PF00002 7 transmembrane receptor (Secretin family), 0.0003 PF00155 Aminotransferase class I and II 0.0003 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0003 PF08742 C8 domain 0.0003 PF00641 Zn-finger in Ran binding protein and others 0.0002 PF01733 Nucleoside transporter 0.0002 PF03953 Tubulin C-terminal domain 0.0002 PF02173 pKID domain 0.0002 PF00620 RhoGAP domain 0.0002 PF00273 Serum albumin family 0.0002 PF00757 Furin-like cysteine rich region 0.0002 PF00091 Tubulin/FtsZ family, GTPase domain 0.0002 PF01030 Receptor L domain 0.0002 PF00170 bZIP transcription factor 0.0001 PF01347 Lipoprotein amino terminal region 0.0001 PF00151 Lipase 0.0001 PF00294 pfkB family carbohydrate kinase SUB640 O-C-C-C-O 0.0463 PF02806 Alpha amylase, C-terminal all-beta domain 0.0351 PF00128 Alpha amylase, catalytic domain 0.0342 PF03414 Glycosyltransferase family 6 0.0225 PF02155 Glucocorticoid receptor 0.0224 PF00191 Annexin 0.0212 PF00079 Serpin (serine protease inhibitor), 0.0199 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0179 PF08070 DTHCT (NUC029), region 0.0179 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0179 PF00204 DNA gyrase B 0.0136 PF00059 Lectin C-type domain 0.0130 PF00167 Fibroblast growth factor 0.0106 PF01048 Phosphorylase superfamily 0.0106 PF00084 Sushi domain (SCR repeat), 0.0105 PF01735 Lysophospholipase catalytic domain 0.0095 PF07654 Immunoglobulin C1-set domain 0.0092 PF00091 Tubulin/FtsZ family, GTPase domain 0.0092 PF03953 Tubulin C-terminal domain 0.0089 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0081 PF02223 Thymidylate kinase 0.0073 PF00143 Interferon alpha/beta domain 0.0061 PF00349 Hexokinase 0.0061 PF03727 Hexokinase 0.0060 PF00303 Thymidylate synthase 0.0055 PF08702 Fibrinogen alpha/beta chain family 0.0055 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0053 PF02267 ADP-ribosyl cyclase 0.0052 PF00106 short chain dehydrogenase 0.0044 PF01370 NAD dependent epimerase/dehydratase family 0.0044 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0042 PF12160 Fibrinogen alpha C domain 0.0040 PF01055 Glycosyl hydrolases family 31 0.0040 PF00088 Trefoil (P-type), domain 0.0037 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0036 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0036 PF07686 Immunoglobulin V-set domain 0.0035 PF02065 Melibiase 0.0035 PF03770 Inositol polyphosphate kinase 0.0035 PF00293 NUDIX domain 0.0033 PF00337 Galactoside-binding lectin 0.0033 PF00328 Histidine acid phosphatase 0.0031 PF00005 ABC transporter 0.0030 PF01607 Chitin binding Peritrophin-A domain 0.0030 PF00704 Glycosyl hydrolases family 18 0.0029 PF07645 Calcium-binding EGF domain 0.0029 PF00690 Cation transporter/ATPase, N-terminus 0.0029 PF00689 Cation transporting ATPase, C-terminus 0.0028 PF01532 Glycosyl hydrolase family 47 0.0027 PF01467 Cytidylyltransferase 0.0026 PF01068 ATP dependent DNA ligase domain 0.0026 PF04679 ATP dependent DNA ligase C terminal region 0.0025 PF00089 Trypsin 0.0023 PF00664 ABC transporter transmembrane region 0.0023 PF00122 E1-E2 ATPase 0.0023 PF00041 Fibronectin type III domain 0.0022 PF00171 Aldehyde dehydrogenase family 0.0020 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0020 PF00431 CUB domain 0.0020 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0019 PF08384 Pro-opiomelanocortin, N-terminal region 0.0019 PF00976 Corticotropin ACTH domain 0.0019 PF08035 Opioids neuropeptide 0.0019 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0018 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.0016 PF00702 haloacid dehalogenase-like hydrolase 0.0013 PF00024 PAN domain 0.0013 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0013 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0013 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0012 PF04711 Apolipoprotein A-II (ApoA-II), 0.0012 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0012 PF00403 Heavy-metal-associated domain 0.0012 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0012 PF00031 Cystatin domain 0.0011 PF00058 Low-density lipoprotein receptor repeat class B 0.0011 PF08240 Alcohol dehydrogenase GroES-like domain 0.0010 PF00057 Low-density lipoprotein receptor domain class A 0.0010 PF07648 Kazal-type serine protease inhibitor domain 0.0009 PF00884 Sulfatase 0.0008 PF02055 O-Glycosyl hydrolase family 30 0.0008 PF03171 2OG-Fe(II), oxygenase superfamily 0.0008 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0007 PF01562 Reprolysin family propeptide 0.0007 PF00090 Thrombospondin type 1 domain 0.0007 PF00093 von Willebrand factor type C domain 0.0007 PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), 0.0007 PF01869 BadF/BadG/BcrA/BcrD ATPase family 0.0007 PF00236 Glycoprotein hormone 0.0007 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0007 PF08516 ADAM cysteine-rich 0.0007 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0007 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 0.0007 PF00248 Aldo/keto reductase family 0.0007 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0007 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0007 PF00021 u-PAR/Ly-6 domain 0.0007 PF00200 Disintegrin 0.0007 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0007 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0007 PF05735 Thrombospondin C-terminal region 0.0007 PF00703 domain 0.0007 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0006 PF01687 Riboflavin kinase 0.0006 PF00107 Zinc-binding dehydrogenase 0.0005 PF03781 Formylglycine-generating sulfatase enzyme 0.0005 PF00183 Hsp90 protein 0.0005 PF10420 Cytokine interleukin-12p40 C-terminus 0.0005 PF00714 Interferon gamma 0.0005 PF00071 Ras family 0.0004 PF01842 ACT domain 0.0004 PF01230 HIT domain 0.0004 PF01122 Eukaryotic cobalamin-binding protein 0.0004 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0003 PF08718 Glycolipid transfer protein (GLTP), 0.0003 PF07884 Vitamin K epoxide reductase family 0.0003 PF00571 CBS domain 0.0002 PF03360 Glycosyltransferase family 43 SUB822 CC1C(N)CCCC1 0.0457 PF08070 DTHCT (NUC029), region 0.0457 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0457 PF00204 DNA gyrase B 0.0182 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0164 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0164 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0105 PF01735 Lysophospholipase catalytic domain 0.0087 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0083 PF00989 PAS fold 0.0083 PF00576 HIUase/Transthyretin family 0.0075 PF00191 Annexin 0.0068 PF00102 Protein-tyrosine phosphatase 0.0067 PF00689 Cation transporting ATPase, C-terminus 0.0067 PF00690 Cation transporter/ATPase, N-terminus 0.0067 PF00027 Cyclic nucleotide-binding domain 0.0066 PF00194 Eukaryotic-type carbonic anhydrase 0.0066 PF02155 Glucocorticoid receptor 0.0065 PF03073 TspO/MBR family 0.0062 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0059 PF00122 E1-E2 ATPase 0.0058 PF02166 Androgen receptor 0.0056 PF00520 Ion transport protein 0.0056 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0052 PF00303 Thymidylate synthase 0.0050 PF03477 ATP cone domain 0.0050 PF00702 haloacid dehalogenase-like hydrolase 0.0050 PF02867 Ribonucleotide reductase, barrel domain 0.0050 PF00079 Serpin (serine protease inhibitor), 0.0050 PF00317 Ribonucleotide reductase, all-alpha domain 0.0049 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0043 PF00146 NADH dehydrogenase 0.0042 PF01180 Dihydroorotate dehydrogenase 0.0039 PF02214 K+ channel tetramerisation domain 0.0039 PF00168 C2 domain 0.0036 PF00757 Furin-like cysteine rich region 0.0036 PF01030 Receptor L domain 0.0032 PF00136 DNA polymerase family B 0.0032 PF08996 DNA Polymerase alpha zinc finger 0.0032 PF03104 DNA polymerase family B, exonuclease domain 0.0030 PF03098 Animal haem peroxidase 0.0030 PF00248 Aldo/keto reductase family 0.0029 PF00493 MCM2/3/5 family 0.0028 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0025 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0024 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0021 PF05406 WGR domain 0.0021 PF00028 Cadherin domain 0.0021 PF08063 PADR1 (NUC008), domain 0.0021 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0021 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0021 PF00533 BRCA1 C Terminus (BRCT), domain 0.0020 PF02460 Patched family 0.0020 PF00069 Protein kinase domain 0.0018 PF00654 Voltage gated chloride channel 0.0018 PF03062 MBOAT family 0.0016 PF12491 Apolipoprotein B100 C terminal 0.0016 PF06448 Domain of Unknown Function (DUF1081), 0.0015 PF02196 Raf-like Ras-binding domain 0.0014 PF01731 Arylesterase 0.0014 PF00489 Interleukin-6/G-CSF/MGF family 0.0013 PF00229 TNF(Tumour Necrosis Factor), family 0.0011 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0011 PF02180 Bcl-2 homology region 4 0.0010 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0008 PF01347 Lipoprotein amino terminal region 0.0007 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0006 PF00554 Rel homology domain (RHD), 0.0005 PF00042 Globin 0.0005 PF00406 Adenylate kinase 0.0005 PF00058 Low-density lipoprotein receptor repeat class B 0.0004 PF02865 STAT protein, protein interaction domain 0.0004 PF02864 STAT protein, DNA binding domain 0.0004 PF01391 Collagen triple helix repeat (20 copies), 0.0004 PF01017 STAT protein, all-alpha domain 0.0004 PF00432 Prenyltransferase and squalene oxidase repeat 0.0004 PF08403 Amino acid permease N-terminal 0.0004 PF09396 Thrombin light chain 0.0003 PF01061 ABC-2 type transporter 0.0003 PF00821 Phosphoenolpyruvate carboxykinase 0.0003 PF01596 O-methyltransferase 0.0002 PF00071 Ras family 0.0001 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0001 PF00656 Caspase domain 0.0001 PF00341 Platelet-derived growth factor (PDGF), 0.0001 PF01433 Peptidase family M1 0.0001 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), SUB546 N-C:C-C 0.0457 PF03073 TspO/MBR family 0.0456 PF00194 Eukaryotic-type carbonic anhydrase 0.0354 PF00186 Dihydrofolate reductase 0.0255 PF00069 Protein kinase domain 0.0197 PF01048 Phosphorylase superfamily 0.0186 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0184 PF00001 7 transmembrane receptor (rhodopsin family), 0.0177 PF08403 Amino acid permease N-terminal 0.0157 PF08070 DTHCT (NUC029), region 0.0157 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0157 PF00204 DNA gyrase B 0.0135 PF06512 Sodium ion transport-associated 0.0107 PF02254 TrkA-N domain 0.0107 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0091 PF00005 ABC transporter 0.0086 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0069 PF00478 IMP dehydrogenase / GMP reductase domain 0.0062 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0061 PF01126 Heme oxygenase 0.0053 PF00962 Adenosine/AMP deaminase 0.0048 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0048 PF01061 ABC-2 type transporter 0.0046 PF00017 SH2 domain 0.0044 PF00520 Ion transport protein 0.0042 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0042 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0041 PF00018 SH3 domain 0.0038 PF01590 GAF domain 0.0035 PF00664 ABC transporter transmembrane region 0.0030 PF00571 CBS domain 0.0029 PF00042 Globin 0.0025 PF00102 Protein-tyrosine phosphatase 0.0024 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0024 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0020 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0016 PF00156 Phosphoribosyl transferase domain 0.0015 PF00464 Serine hydroxymethyltransferase 0.0012 PF08919 F-actin binding 0.0011 PF00858 Amiloride-sensitive sodium channel 0.0010 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0010 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0010 PF01268 Formate--tetrahydrofolate ligase 0.0007 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB49 >= 4 I 0.0435 PF00273 Serum albumin family 0.0336 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0316 PF08534 Redoxin 0.0164 PF00854 POT family 0.0091 PF09396 Thrombin light chain 0.0077 PF02180 Bcl-2 homology region 4 0.0077 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0058 PF02460 Patched family 0.0057 PF03062 MBOAT family 0.0057 PF01731 Arylesterase 0.0055 PF00151 Lipase 0.0045 PF00069 Protein kinase domain 0.0039 PF01431 Peptidase family M13 0.0039 PF01401 Angiotensin-converting enzyme 0.0039 PF05649 Peptidase family M13 0.0038 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0038 PF00975 Thioesterase domain 0.0038 PF08659 KR domain 0.0038 PF00698 Acyl transferase domain 0.0038 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0033 PF01477 PLAT/LH2 domain 0.0032 PF01433 Peptidase family M1 0.0028 PF00051 Kringle domain 0.0027 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0022 PF00576 HIUase/Transthyretin family 0.0021 PF00550 Phosphopantetheine attachment site 0.0021 PF00343 Carbohydrate phosphorylase 0.0018 PF00134 Cyclin, N-terminal domain 0.0018 PF02984 Cyclin, C-terminal domain 0.0018 PF12126 Protein of unknown function (DUF3583), 0.0018 PF07970 Endoplasmic reticulum vesicle transporter 0.0018 PF00059 Lectin C-type domain 0.0017 PF03953 Tubulin C-terminal domain 0.0017 PF03957 Jun-like transcription factor 0.0017 PF00489 Interleukin-6/G-CSF/MGF family 0.0017 PF00091 Tubulin/FtsZ family, GTPase domain 0.0015 PF02423 Ornithine cyclodeaminase/mu-crystallin family 0.0015 PF07645 Calcium-binding EGF domain 0.0014 PF00664 ABC transporter transmembrane region 0.0010 PF00107 Zinc-binding dehydrogenase 0.0010 PF00170 bZIP transcription factor 0.0010 PF00005 ABC transporter 0.0009 PF00643 B-box zinc finger 0.0007 PF00089 Trypsin 0.0005 PF00433 Protein kinase C terminal domain 0.0002 PF00169 PH domain 0.0001 PF03098 Animal haem peroxidase 0.0001 PF00328 Histidine acid phosphatase 0.0001 PF00462 Glutaredoxin SUB568 O-C-C-O 0.0433 PF00191 Annexin 0.0399 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0378 PF02806 Alpha amylase, C-terminal all-beta domain 0.0355 PF02155 Glucocorticoid receptor 0.0265 PF00128 Alpha amylase, catalytic domain 0.0257 PF03414 Glycosyltransferase family 6 0.0234 PF00079 Serpin (serine protease inhibitor), 0.0213 PF01048 Phosphorylase superfamily 0.0185 PF00091 Tubulin/FtsZ family, GTPase domain 0.0185 PF03953 Tubulin C-terminal domain 0.0163 PF02223 Thymidylate kinase 0.0134 PF01735 Lysophospholipase catalytic domain 0.0121 PF00303 Thymidylate synthase 0.0105 PF00106 short chain dehydrogenase 0.0087 PF00059 Lectin C-type domain 0.0085 PF00167 Fibroblast growth factor 0.0074 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0070 PF03770 Inositol polyphosphate kinase 0.0063 PF00005 ABC transporter 0.0060 PF01607 Chitin binding Peritrophin-A domain 0.0060 PF00704 Glycosyl hydrolases family 18 0.0055 PF01467 Cytidylyltransferase 0.0046 PF00084 Sushi domain (SCR repeat), 0.0046 PF00664 ABC transporter transmembrane region 0.0045 PF02267 ADP-ribosyl cyclase 0.0043 PF00171 Aldehyde dehydrogenase family 0.0042 PF03727 Hexokinase 0.0042 PF00349 Hexokinase 0.0041 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0041 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0040 PF07654 Immunoglobulin C1-set domain 0.0038 PF08384 Pro-opiomelanocortin, N-terminal region 0.0038 PF08035 Opioids neuropeptide 0.0038 PF00976 Corticotropin ACTH domain 0.0037 PF01370 NAD dependent epimerase/dehydratase family 0.0037 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.0031 PF01532 Glycosyl hydrolase family 47 0.0026 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0026 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0026 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0021 PF08240 Alcohol dehydrogenase GroES-like domain 0.0014 PF00248 Aldo/keto reductase family 0.0013 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0012 PF00143 Interferon alpha/beta domain 0.0012 PF00107 Zinc-binding dehydrogenase 0.0011 PF00071 Ras family 0.0011 PF01687 Riboflavin kinase 0.0008 PF01842 ACT domain 0.0007 PF01230 HIT domain 0.0007 PF01122 Eukaryotic cobalamin-binding protein 0.0006 PF00571 CBS domain 0.0004 PF03360 Glycosyltransferase family 43 0.0002 PF01055 Glycosyl hydrolases family 31 0.0002 PF00088 Trefoil (P-type), domain SUB48 >= 2 I 0.0429 PF00273 Serum albumin family 0.0332 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0312 PF08534 Redoxin 0.0162 PF00854 POT family 0.0090 PF09396 Thrombin light chain 0.0076 PF02180 Bcl-2 homology region 4 0.0076 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0057 PF02460 Patched family 0.0057 PF03062 MBOAT family 0.0056 PF01731 Arylesterase 0.0054 PF00151 Lipase 0.0045 PF00069 Protein kinase domain 0.0038 PF00698 Acyl transferase domain 0.0038 PF08659 KR domain 0.0038 PF00975 Thioesterase domain 0.0038 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0038 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0038 PF01431 Peptidase family M13 0.0038 PF01401 Angiotensin-converting enzyme 0.0038 PF05649 Peptidase family M13 0.0033 PF01477 PLAT/LH2 domain 0.0031 PF01433 Peptidase family M1 0.0028 PF00051 Kringle domain 0.0027 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0022 PF00576 HIUase/Transthyretin family 0.0021 PF00550 Phosphopantetheine attachment site 0.0021 PF00343 Carbohydrate phosphorylase 0.0018 PF00059 Lectin C-type domain 0.0018 PF12126 Protein of unknown function (DUF3583), 0.0018 PF00134 Cyclin, N-terminal domain 0.0018 PF02984 Cyclin, C-terminal domain 0.0018 PF07970 Endoplasmic reticulum vesicle transporter 0.0017 PF03953 Tubulin C-terminal domain 0.0017 PF00091 Tubulin/FtsZ family, GTPase domain 0.0016 PF00489 Interleukin-6/G-CSF/MGF family 0.0016 PF03957 Jun-like transcription factor 0.0015 PF02423 Ornithine cyclodeaminase/mu-crystallin family 0.0015 PF07645 Calcium-binding EGF domain 0.0013 PF00664 ABC transporter transmembrane region 0.0010 PF00170 bZIP transcription factor 0.0010 PF00005 ABC transporter 0.0009 PF00643 B-box zinc finger 0.0009 PF00107 Zinc-binding dehydrogenase 0.0007 PF00089 Trypsin 0.0005 PF00433 Protein kinase C terminal domain 0.0002 PF00169 PH domain 0.0001 PF03098 Animal haem peroxidase 0.0001 PF00462 Glutaredoxin 0.0001 PF00328 Histidine acid phosphatase SUB626 O=C-C:C-O 0.0423 PF00155 Aminotransferase class I and II 0.0405 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0400 PF00266 Aminotransferase class-V 0.0296 PF00464 Serine hydroxymethyltransferase 0.0265 PF00291 Pyridoxal-phosphate dependent enzyme 0.0252 PF00202 Aminotransferase class-III 0.0240 PF01063 Aminotransferase class IV 0.0233 PF00343 Carbohydrate phosphorylase 0.0195 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.0195 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0167 PF00294 pfkB family carbohydrate kinase 0.0139 PF00702 haloacid dehalogenase-like hydrolase 0.0098 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 0.0098 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0098 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0098 PF03473 MOSC domain 0.0098 PF03476 MOSC N-terminal beta barrel domain 0.0096 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0096 PF01168 Alanine racemase, N-terminal domain 0.0096 PF02347 Glycine cleavage system P-protein 0.0096 PF01212 Beta-eliminating lyase 0.0096 PF01202 Shikimate kinase 0.0095 PF04961 Formiminotransferase-cyclodeaminase 0.0095 PF02971 Formiminotransferase domain 0.0095 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0093 PF07706 Aminotransferase ubiquitination site 0.0070 PF01596 O-methyltransferase 0.0067 PF00204 DNA gyrase B 0.0067 PF08070 DTHCT (NUC029), region 0.0067 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0061 PF00571 CBS domain 0.0029 PF00690 Cation transporter/ATPase, N-terminus 0.0029 PF00689 Cation transporting ATPase, C-terminus 0.0027 PF00576 HIUase/Transthyretin family 0.0024 PF00340 Interleukin-1 / 18 0.0024 PF02394 Interleukin-1 propeptide 0.0023 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0022 PF00342 Phosphoglucose isomerase 0.0022 PF00122 E1-E2 ATPase 0.0021 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0021 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0016 PF01588 Putative tRNA binding domain 0.0014 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0014 PF01916 Deoxyhypusine synthase 0.0013 PF01735 Lysophospholipase catalytic domain 0.0011 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0011 PF00989 PAS fold 0.0010 PF00191 Annexin 0.0009 PF00102 Protein-tyrosine phosphatase 0.0009 PF00027 Cyclic nucleotide-binding domain 0.0008 PF02155 Glucocorticoid receptor 0.0008 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0008 PF00194 Eukaryotic-type carbonic anhydrase 0.0008 PF03073 TspO/MBR family 0.0007 PF00520 Ion transport protein 0.0007 PF02166 Androgen receptor 0.0007 PF00303 Thymidylate synthase 0.0006 PF00317 Ribonucleotide reductase, all-alpha domain 0.0006 PF00146 NADH dehydrogenase 0.0006 PF00149 Calcineurin-like phosphoesterase 0.0006 PF03477 ATP cone domain 0.0006 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0006 PF00079 Serpin (serine protease inhibitor), 0.0006 PF02867 Ribonucleotide reductase, barrel domain 0.0005 PF01180 Dihydroorotate dehydrogenase 0.0005 PF01030 Receptor L domain 0.0005 PF00757 Furin-like cysteine rich region 0.0005 PF00168 C2 domain 0.0005 PF02214 K+ channel tetramerisation domain 0.0004 PF00136 DNA polymerase family B 0.0004 PF00493 MCM2/3/5 family 0.0004 PF03104 DNA polymerase family B, exonuclease domain 0.0004 PF08996 DNA Polymerase alpha zinc finger 0.0004 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0004 PF00248 Aldo/keto reductase family 0.0004 PF03098 Animal haem peroxidase 0.0003 PF00533 BRCA1 C Terminus (BRCT), domain 0.0003 PF05406 WGR domain 0.0003 PF00069 Protein kinase domain 0.0003 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0003 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0003 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0003 PF00028 Cadherin domain 0.0003 PF02460 Patched family 0.0003 PF08063 PADR1 (NUC008), domain 0.0003 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0002 PF06448 Domain of Unknown Function (DUF1081), 0.0002 PF12491 Apolipoprotein B100 C terminal 0.0002 PF00654 Voltage gated chloride channel 0.0002 PF03062 MBOAT family 0.0002 PF00489 Interleukin-6/G-CSF/MGF family 0.0002 PF00229 TNF(Tumour Necrosis Factor), family 0.0002 PF01731 Arylesterase 0.0002 PF02196 Raf-like Ras-binding domain 0.0001 PF01391 Collagen triple helix repeat (20 copies), 0.0001 PF00406 Adenylate kinase 0.0001 PF00554 Rel homology domain (RHD), 0.0001 PF01017 STAT protein, all-alpha domain 0.0001 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0001 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0001 PF00058 Low-density lipoprotein receptor repeat class B 0.0001 PF01347 Lipoprotein amino terminal region 0.0001 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0001 PF00042 Globin 0.0001 PF02180 Bcl-2 homology region 4 0.0001 PF02865 STAT protein, protein interaction domain 0.0001 PF02864 STAT protein, DNA binding domain SUB375 C(~H)(~H)(~H) 0.0420 PF00001 7 transmembrane receptor (rhodopsin family), 0.0356 PF02159 Oestrogen receptor 0.0333 PF00105 Zinc finger, C4 type (two domains), 0.0330 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0196 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0138 PF08070 DTHCT (NUC029), region 0.0138 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0138 PF00204 DNA gyrase B 0.0112 PF00209 Sodium:neurotransmitter symporter family 0.0084 PF03098 Animal haem peroxidase 0.0072 PF03953 Tubulin C-terminal domain 0.0072 PF00091 Tubulin/FtsZ family, GTPase domain 0.0070 PF00191 Annexin 0.0067 PF02155 Glucocorticoid receptor 0.0062 PF00989 PAS fold 0.0061 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0059 PF02161 Progesterone receptor 0.0055 PF00005 ABC transporter 0.0051 PF00027 Cyclic nucleotide-binding domain 0.0044 PF00664 ABC transporter transmembrane region 0.0035 PF01735 Lysophospholipase catalytic domain 0.0034 PF00067 Cytochrome P450 0.0034 PF00079 Serpin (serine protease inhibitor), 0.0032 PF12497 Estrogen receptor beta 0.0030 PF02166 Androgen receptor 0.0030 PF09396 Thrombin light chain 0.0025 PF08384 Pro-opiomelanocortin, N-terminal region 0.0025 PF08035 Opioids neuropeptide 0.0025 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0025 PF00976 Corticotropin ACTH domain 0.0024 PF00273 Serum albumin family 0.0018 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0016 PF00168 C2 domain 0.0012 PF11825 Protein of unknown function (DUF3345), 0.0011 PF01477 PLAT/LH2 domain 0.0011 PF03414 Glycosyltransferase family 6 0.0010 PF00822 PMP-22/EMP/MP20/Claudin family 0.0009 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0009 PF01593 Flavin containing amine oxidoreductase 0.0008 PF03073 TspO/MBR family 0.0007 PF02806 Alpha amylase, C-terminal all-beta domain 0.0006 PF07966 A1 Propeptide 0.0005 PF01401 Angiotensin-converting enzyme 0.0005 PF00026 Eukaryotic aspartyl protease 0.0004 PF00305 Lipoxygenase 0.0003 PF00151 Lipase 0.0003 PF00183 Hsp90 protein 0.0003 PF07648 Kazal-type serine protease inhibitor domain 0.0002 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0002 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0002 PF00340 Interleukin-1 / 18 0.0002 PF08763 Voltage gated calcium channel IQ domain 0.0002 PF00059 Lectin C-type domain 0.0002 PF01061 ABC-2 type transporter 0.0002 PF02394 Interleukin-1 propeptide 0.0001 PF08441 Integrin alpha 0.0001 PF00229 TNF(Tumour Necrosis Factor), family 0.0001 PF00643 B-box zinc finger 0.0001 PF00128 Alpha amylase, catalytic domain SUB507 C-C:N:C 0.0416 PF00227 Proteasome subunit 0.0130 PF00069 Protein kinase domain 0.0127 PF01048 Phosphorylase superfamily 0.0118 PF00186 Dihydrofolate reductase 0.0115 PF03073 TspO/MBR family 0.0089 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0085 PF00478 IMP dehydrogenase / GMP reductase domain 0.0059 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0058 PF00571 CBS domain 0.0051 PF00962 Adenosine/AMP deaminase 0.0035 PF00156 Phosphoribosyl transferase domain 0.0035 PF01590 GAF domain 0.0031 PF08240 Alcohol dehydrogenase GroES-like domain 0.0029 PF00107 Zinc-binding dehydrogenase 0.0028 PF00091 Tubulin/FtsZ family, GTPase domain 0.0028 PF03953 Tubulin C-terminal domain 0.0026 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0026 PF01126 Heme oxygenase 0.0025 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0025 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0023 PF00017 SH2 domain 0.0023 PF00858 Amiloride-sensitive sodium channel 0.0022 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0022 PF00106 short chain dehydrogenase 0.0022 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0020 PF00018 SH3 domain 0.0016 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0016 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0016 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0013 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0012 PF00042 Globin 0.0012 PF00171 Aldehyde dehydrogenase family 0.0012 PF08919 F-actin binding 0.0011 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0011 PF01467 Cytidylyltransferase 0.0011 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0009 PF00501 AMP-binding enzyme 0.0009 PF01122 Eukaryotic cobalamin-binding protein 0.0009 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0008 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0008 PF12423 Kinesin protein 1B 0.0008 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0008 PF01119 DNA mismatch repair protein, C-terminal domain 0.0008 PF00821 Phosphoenolpyruvate carboxykinase 0.0008 PF01575 MaoC like domain 0.0008 PF02036 SCP-2 sterol transfer family 0.0008 PF01652 Eukaryotic initiation factor 4E 0.0008 PF12473 Kinesin protein 0.0008 PF00970 Oxidoreductase FAD-binding domain 0.0008 PF00136 DNA polymerase family B 0.0008 PF08996 DNA Polymerase alpha zinc finger 0.0008 PF03104 DNA polymerase family B, exonuclease domain 0.0008 PF00498 FHA domain 0.0008 PF02267 ADP-ribosyl cyclase 0.0008 PF10397 Adenylosuccinate lyase C-terminus 0.0008 PF08676 MutL C terminal dimerisation domain 0.0007 PF02223 Thymidylate kinase 0.0007 PF01808 AICARFT/IMPCHase bienzyme 0.0007 PF00225 Kinesin motor domain 0.0007 PF01230 HIT domain 0.0006 PF00400 WD domain, G-beta repeat 0.0006 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0006 PF07966 A1 Propeptide 0.0006 PF00071 Ras family 0.0006 PF00690 Cation transporter/ATPase, N-terminus 0.0006 PF00689 Cation transporting ATPase, C-terminus 0.0006 PF00931 NB-ARC domain 0.0006 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0006 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0006 PF02233 NAD(P), transhydrogenase beta subunit 0.0006 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0006 PF02525 Flavodoxin-like fold 0.0006 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0006 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0006 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0005 PF00378 Enoyl-CoA hydratase/isomerase family 0.0005 PF01923 Cobalamin adenosyltransferase 0.0005 PF00390 Malic enzyme, N-terminal domain 0.0005 PF01064 Activin types I and II receptor domain 0.0005 PF00958 GMP synthase C terminal domain 0.0005 PF02867 Ribonucleotide reductase, barrel domain 0.0005 PF03477 ATP cone domain 0.0005 PF00676 Dehydrogenase E1 component 0.0005 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0005 PF00317 Ribonucleotide reductase, all-alpha domain 0.0005 PF00343 Carbohydrate phosphorylase 0.0005 PF03770 Inositol polyphosphate kinase 0.0005 PF03949 Malic enzyme, NAD binding domain 0.0005 PF08515 Transforming growth factor beta type I GS-motif 0.0005 PF03308 ArgK protein 0.0005 PF01642 Methylmalonyl-CoA mutase 0.0005 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF00702 haloacid dehalogenase-like hydrolase 0.0004 PF03024 Folate receptor family 0.0004 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0004 PF00536 SAM domain (Sterile alpha motif), 0.0004 PF01068 ATP dependent DNA ligase domain 0.0004 PF00025 ADP-ribosylation factor family 0.0004 PF01404 Ephrin receptor ligand binding domain 0.0004 PF09027 GTPase binding 0.0004 PF00248 Aldo/keto reductase family 0.0004 PF04679 ATP dependent DNA ligase C terminal region 0.0004 PF00122 E1-E2 ATPase 0.0004 PF00334 Nucleoside diphosphate kinase 0.0004 PF11555 EGFR receptor inhibitor Mig-6 0.0004 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0004 PF00005 ABC transporter 0.0004 PF00310 Glutamine amidotransferases class-II 0.0003 PF01030 Receptor L domain 0.0003 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0003 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0003 PF05347 Complex 1 protein (LYR family), 0.0003 PF01712 Deoxynucleoside kinase 0.0003 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0003 PF00757 Furin-like cysteine rich region 0.0003 PF00206 Lyase 0.0003 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0003 PF02310 B12 binding domain 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF00533 BRCA1 C Terminus (BRCT), domain 0.0002 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0002 PF00794 PI3-kinase family, ras-binding domain 0.0002 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF03530 Calcium-activated SK potassium channel 0.0002 PF05406 WGR domain 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0002 PF08063 PADR1 (NUC008), domain 0.0002 PF02888 Calmodulin binding domain 0.0002 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0002 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0002 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF01916 Deoxyhypusine synthase 0.0002 PF02779 Transketolase, pyrimidine binding domain 0.0001 PF01747 ATP-sulfurylase 0.0001 PF02772 S-adenosylmethionine synthetase, central domain 0.0001 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF02173 pKID domain 0.0001 PF00439 Bromodomain 0.0001 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0001 PF00899 ThiF family 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF02037 SAP domain 0.0001 PF01583 Adenylylsulphate kinase 0.0001 PF01582 TIR domain 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF00300 Phosphoglycerate mutase family 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF00288 GHMP kinases N terminal domain 0.0001 PF00287 Sodium / potassium ATPase beta chain 0.0001 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF01591 6-phosphofructo-2-kinase 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF10531 SLBB domain 0.0001 PF01434 Peptidase family M41 0.0001 PF00004 ATPase family associated with various cellular activities (AAA), 0.0001 PF00002 7 transmembrane receptor (Secretin family), 0.0001 PF02793 Hormone receptor domain 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF00316 Fructose-1-6-bisphosphatase 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF08040 MNLL subunit 0.0001 PF00183 Hsp90 protein 0.0001 PF00291 Pyridoxal-phosphate dependent enzyme 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0001 PF02493 MORN repeat 0.0001 PF00629 MAM domain 0.0001 PF10276 Zinc-finger domain 0.0001 PF10509 Galactokinase galactose-binding signature 0.0001 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF00012 Hsp70 protein 0.0001 PF00615 Regulator of G protein signaling domain 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF00221 Phenylalanine and histidine ammonia-lyase 0.0001 PF02142 MGS-like domain 0.0001 PF06212 GRIM-19 protein 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF02803 Thiolase, C-terminal domain 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF01017 STAT protein, all-alpha domain 0.0001 PF02817 e3 binding domain 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF00108 Thiolase, N-terminal domain 0.0001 PF08544 GHMP kinases C terminal 0.0001 PF02196 Raf-like Ras-binding domain 0.0001 PF00026 Eukaryotic aspartyl protease 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF02865 STAT protein, protein interaction domain 0.0001 PF02864 STAT protein, DNA binding domain 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF12062 heparan sulfate-N-deacetylase 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF01687 Riboflavin kinase 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF00856 SET domain 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF01835 MG2 domain 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), SUB473 C:N:C-C 0.0416 PF00227 Proteasome subunit 0.0130 PF00069 Protein kinase domain 0.0127 PF01048 Phosphorylase superfamily 0.0118 PF00186 Dihydrofolate reductase 0.0115 PF03073 TspO/MBR family 0.0089 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0085 PF00478 IMP dehydrogenase / GMP reductase domain 0.0059 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0058 PF00571 CBS domain 0.0051 PF00962 Adenosine/AMP deaminase 0.0035 PF01590 GAF domain 0.0035 PF00156 Phosphoribosyl transferase domain 0.0031 PF08240 Alcohol dehydrogenase GroES-like domain 0.0029 PF00107 Zinc-binding dehydrogenase 0.0028 PF03953 Tubulin C-terminal domain 0.0028 PF00091 Tubulin/FtsZ family, GTPase domain 0.0026 PF01126 Heme oxygenase 0.0026 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0025 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0025 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0023 PF00017 SH2 domain 0.0023 PF00858 Amiloride-sensitive sodium channel 0.0022 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0022 PF00106 short chain dehydrogenase 0.0022 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0020 PF00018 SH3 domain 0.0016 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0016 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0016 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0013 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0012 PF00042 Globin 0.0012 PF08919 F-actin binding 0.0012 PF00171 Aldehyde dehydrogenase family 0.0011 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0011 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0011 PF01467 Cytidylyltransferase 0.0009 PF00501 AMP-binding enzyme 0.0009 PF01122 Eukaryotic cobalamin-binding protein 0.0009 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0008 PF10397 Adenylosuccinate lyase C-terminus 0.0008 PF00498 FHA domain 0.0008 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0008 PF00136 DNA polymerase family B 0.0008 PF08676 MutL C terminal dimerisation domain 0.0008 PF12473 Kinesin protein 0.0008 PF00970 Oxidoreductase FAD-binding domain 0.0008 PF00821 Phosphoenolpyruvate carboxykinase 0.0008 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0008 PF02036 SCP-2 sterol transfer family 0.0008 PF03104 DNA polymerase family B, exonuclease domain 0.0008 PF02267 ADP-ribosyl cyclase 0.0008 PF08996 DNA Polymerase alpha zinc finger 0.0008 PF01575 MaoC like domain 0.0008 PF01652 Eukaryotic initiation factor 4E 0.0008 PF12423 Kinesin protein 1B 0.0008 PF01119 DNA mismatch repair protein, C-terminal domain 0.0007 PF01230 HIT domain 0.0007 PF02223 Thymidylate kinase 0.0007 PF00225 Kinesin motor domain 0.0007 PF01808 AICARFT/IMPCHase bienzyme 0.0006 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0006 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0006 PF02233 NAD(P), transhydrogenase beta subunit 0.0006 PF00689 Cation transporting ATPase, C-terminus 0.0006 PF02525 Flavodoxin-like fold 0.0006 PF00690 Cation transporter/ATPase, N-terminus 0.0006 PF00071 Ras family 0.0006 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0006 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0006 PF00931 NB-ARC domain 0.0006 PF00400 WD domain, G-beta repeat 0.0006 PF07966 A1 Propeptide 0.0006 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0006 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0006 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0005 PF00958 GMP synthase C terminal domain 0.0005 PF00702 haloacid dehalogenase-like hydrolase 0.0005 PF08515 Transforming growth factor beta type I GS-motif 0.0005 PF01064 Activin types I and II receptor domain 0.0005 PF00390 Malic enzyme, N-terminal domain 0.0005 PF03949 Malic enzyme, NAD binding domain 0.0005 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0005 PF03308 ArgK protein 0.0005 PF03770 Inositol polyphosphate kinase 0.0005 PF00378 Enoyl-CoA hydratase/isomerase family 0.0005 PF01642 Methylmalonyl-CoA mutase 0.0005 PF02867 Ribonucleotide reductase, barrel domain 0.0005 PF03477 ATP cone domain 0.0005 PF00343 Carbohydrate phosphorylase 0.0005 PF01923 Cobalamin adenosyltransferase 0.0005 PF00317 Ribonucleotide reductase, all-alpha domain 0.0005 PF00676 Dehydrogenase E1 component 0.0004 PF00005 ABC transporter 0.0004 PF09027 GTPase binding 0.0004 PF00122 E1-E2 ATPase 0.0004 PF00310 Glutamine amidotransferases class-II 0.0004 PF01404 Ephrin receptor ligand binding domain 0.0004 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0004 PF11555 EGFR receptor inhibitor Mig-6 0.0004 PF00334 Nucleoside diphosphate kinase 0.0004 PF00248 Aldo/keto reductase family 0.0004 PF00536 SAM domain (Sterile alpha motif), 0.0004 PF03024 Folate receptor family 0.0004 PF04679 ATP dependent DNA ligase C terminal region 0.0004 PF00025 ADP-ribosylation factor family 0.0004 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0004 PF01068 ATP dependent DNA ligase domain 0.0003 PF00206 Lyase 0.0003 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0003 PF01712 Deoxynucleoside kinase 0.0003 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0003 PF00757 Furin-like cysteine rich region 0.0003 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0003 PF02310 B12 binding domain 0.0003 PF01030 Receptor L domain 0.0003 PF05347 Complex 1 protein (LYR family), 0.0003 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0002 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0002 PF05406 WGR domain 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF01916 Deoxyhypusine synthase 0.0002 PF03530 Calcium-activated SK potassium channel 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF00533 BRCA1 C Terminus (BRCT), domain 0.0002 PF02779 Transketolase, pyrimidine binding domain 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0002 PF02888 Calmodulin binding domain 0.0002 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF00794 PI3-kinase family, ras-binding domain 0.0002 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0002 PF08063 PADR1 (NUC008), domain 0.0001 PF00012 Hsp70 protein 0.0001 PF00026 Eukaryotic aspartyl protease 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF00291 Pyridoxal-phosphate dependent enzyme 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF00615 Regulator of G protein signaling domain 0.0001 PF02817 e3 binding domain 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF10276 Zinc-finger domain 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF00221 Phenylalanine and histidine ammonia-lyase 0.0001 PF02173 pKID domain 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF00899 ThiF family 0.0001 PF02142 MGS-like domain 0.0001 PF00300 Phosphoglycerate mutase family 0.0001 PF02793 Hormone receptor domain 0.0001 PF08040 MNLL subunit 0.0001 PF00183 Hsp90 protein 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF01835 MG2 domain 0.0001 PF00629 MAM domain 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF02196 Raf-like Ras-binding domain 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0001 PF02772 S-adenosylmethionine synthetase, central domain 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF00856 SET domain 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF02803 Thiolase, C-terminal domain 0.0001 PF02037 SAP domain 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF06212 GRIM-19 protein 0.0001 PF01582 TIR domain 0.0001 PF01583 Adenylylsulphate kinase 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF10531 SLBB domain 0.0001 PF02493 MORN repeat 0.0001 PF01591 6-phosphofructo-2-kinase 0.0001 PF08544 GHMP kinases C terminal 0.0001 PF01687 Riboflavin kinase 0.0001 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0001 PF00316 Fructose-1-6-bisphosphatase 0.0001 PF10509 Galactokinase galactose-binding signature 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF02865 STAT protein, protein interaction domain 0.0001 PF02864 STAT protein, DNA binding domain 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF00439 Bromodomain 0.0001 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0001 PF01434 Peptidase family M41 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF01017 STAT protein, all-alpha domain 0.0001 PF01747 ATP-sulfurylase 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF12062 heparan sulfate-N-deacetylase 0.0001 PF00288 GHMP kinases N terminal domain 0.0001 PF00287 Sodium / potassium ATPase beta chain 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF00004 ATPase family associated with various cellular activities (AAA), 0.0001 PF00002 7 transmembrane receptor (Secretin family), 0.0001 PF00108 Thiolase, N-terminal domain 0.0001 PF04116 Fatty acid hydroxylase superfamily SUB664 O-C-C-O-[#1] 0.0411 PF00191 Annexin 0.0378 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0377 PF02806 Alpha amylase, C-terminal all-beta domain 0.0340 PF02155 Glucocorticoid receptor 0.0266 PF00128 Alpha amylase, catalytic domain 0.0258 PF03414 Glycosyltransferase family 6 0.0228 PF00079 Serpin (serine protease inhibitor), 0.0202 PF01048 Phosphorylase superfamily 0.0175 PF00091 Tubulin/FtsZ family, GTPase domain 0.0175 PF03953 Tubulin C-terminal domain 0.0154 PF02223 Thymidylate kinase 0.0129 PF01735 Lysophospholipase catalytic domain 0.0115 PF00303 Thymidylate synthase 0.0100 PF00106 short chain dehydrogenase 0.0088 PF00059 Lectin C-type domain 0.0086 PF00167 Fibroblast growth factor 0.0071 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0067 PF03770 Inositol polyphosphate kinase 0.0060 PF00005 ABC transporter 0.0057 PF01607 Chitin binding Peritrophin-A domain 0.0057 PF00704 Glycosyl hydrolases family 18 0.0052 PF01467 Cytidylyltransferase 0.0049 PF00084 Sushi domain (SCR repeat), 0.0044 PF02267 ADP-ribosyl cyclase 0.0043 PF07654 Immunoglobulin C1-set domain 0.0043 PF00664 ABC transporter transmembrane region 0.0042 PF00349 Hexokinase 0.0042 PF03727 Hexokinase 0.0041 PF00171 Aldehyde dehydrogenase family 0.0038 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0038 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0037 PF01370 NAD dependent epimerase/dehydratase family 0.0036 PF08035 Opioids neuropeptide 0.0036 PF00976 Corticotropin ACTH domain 0.0036 PF08384 Pro-opiomelanocortin, N-terminal region 0.0035 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.0030 PF01532 Glycosyl hydrolase family 47 0.0025 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0025 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0025 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0020 PF08240 Alcohol dehydrogenase GroES-like domain 0.0015 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0015 PF00143 Interferon alpha/beta domain 0.0013 PF00248 Aldo/keto reductase family 0.0012 PF00204 DNA gyrase B 0.0012 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0012 PF08070 DTHCT (NUC029), region 0.0011 PF01687 Riboflavin kinase 0.0011 PF00107 Zinc-binding dehydrogenase 0.0010 PF00071 Ras family 0.0007 PF01842 ACT domain 0.0007 PF01230 HIT domain 0.0007 PF01122 Eukaryotic cobalamin-binding protein 0.0006 PF00571 CBS domain 0.0006 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0004 PF08702 Fibrinogen alpha/beta chain family 0.0004 PF01055 Glycosyl hydrolases family 31 0.0004 PF00088 Trefoil (P-type), domain 0.0004 PF03360 Glycosyltransferase family 43 0.0004 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0003 PF12160 Fibrinogen alpha C domain 0.0002 PF00293 NUDIX domain 0.0002 PF00041 Fibronectin type III domain 0.0002 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0002 PF00337 Galactoside-binding lectin 0.0002 PF07645 Calcium-binding EGF domain 0.0002 PF00328 Histidine acid phosphatase 0.0002 PF01068 ATP dependent DNA ligase domain 0.0002 PF00690 Cation transporter/ATPase, N-terminus 0.0002 PF00089 Trypsin 0.0002 PF00122 E1-E2 ATPase 0.0002 PF02065 Melibiase 0.0002 PF07686 Immunoglobulin V-set domain 0.0002 PF00689 Cation transporting ATPase, C-terminus 0.0002 PF04679 ATP dependent DNA ligase C terminal region 0.0001 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0001 PF00403 Heavy-metal-associated domain 0.0001 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0001 PF00702 haloacid dehalogenase-like hydrolase 0.0001 PF02055 O-Glycosyl hydrolase family 30 0.0001 PF00884 Sulfatase 0.0001 PF00057 Low-density lipoprotein receptor domain class A 0.0001 PF00058 Low-density lipoprotein receptor repeat class B 0.0001 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0001 PF00431 CUB domain 0.0001 PF04711 Apolipoprotein A-II (ApoA-II), 0.0001 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0001 PF07648 Kazal-type serine protease inhibitor domain 0.0001 PF03171 2OG-Fe(II), oxygenase superfamily 0.0001 PF00024 PAN domain 0.0001 PF00031 Cystatin domain SUB444 C(-C)(=O) 0.0406 PF03098 Animal haem peroxidase 0.0319 PF00273 Serum albumin family 0.0296 PF08070 DTHCT (NUC029), region 0.0296 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0296 PF00204 DNA gyrase B 0.0203 PF01401 Angiotensin-converting enzyme 0.0202 PF00191 Annexin 0.0200 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0195 PF00105 Zinc finger, C4 type (two domains), 0.0193 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0190 PF02155 Glucocorticoid receptor 0.0160 PF00576 HIUase/Transthyretin family 0.0142 PF00102 Protein-tyrosine phosphatase 0.0120 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0116 PF00079 Serpin (serine protease inhibitor), 0.0103 PF01063 Aminotransferase class IV 0.0092 PF00091 Tubulin/FtsZ family, GTPase domain 0.0092 PF03953 Tubulin C-terminal domain 0.0072 PF00155 Aminotransferase class I and II 0.0069 PF02159 Oestrogen receptor 0.0061 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0047 PF00202 Aminotransferase class-III 0.0044 PF01842 ACT domain 0.0040 PF00557 Metallopeptidase family M24 0.0038 PF00303 Thymidylate synthase 0.0038 PF02806 Alpha amylase, C-terminal all-beta domain 0.0036 PF01735 Lysophospholipase catalytic domain 0.0033 PF02166 Androgen receptor 0.0030 PF05649 Peptidase family M13 0.0030 PF01431 Peptidase family M13 0.0023 PF00464 Serine hydroxymethyltransferase 0.0022 PF00128 Alpha amylase, catalytic domain 0.0022 PF01268 Formate--tetrahydrofolate ligase 0.0017 PF01126 Heme oxygenase 0.0015 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0015 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0014 PF11825 Protein of unknown function (DUF3345), 0.0012 PF02798 Glutathione S-transferase, N-terminal domain 0.0011 PF03414 Glycosyltransferase family 6 0.0011 PF00248 Aldo/keto reductase family 0.0010 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0010 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0010 PF00043 Glutathione S-transferase, C-terminal domain 0.0008 PF00733 Asparagine synthase 0.0006 PF00291 Pyridoxal-phosphate dependent enzyme 0.0006 PF00175 Oxidoreductase NAD-binding domain 0.0005 PF09396 Thrombin light chain 0.0005 PF02898 Nitric oxide synthase, oxygenase domain 0.0004 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0004 PF00571 CBS domain 0.0003 PF00266 Aminotransferase class-V 0.0003 PF00024 PAN domain 0.0003 PF03171 2OG-Fe(II), oxygenase superfamily 0.0003 PF00822 PMP-22/EMP/MP20/Claudin family 0.0003 PF00071 Ras family 0.0003 PF07706 Aminotransferase ubiquitination site 0.0003 PF00151 Lipase 0.0002 PF02574 Homocysteine S-methyltransferase 0.0002 PF00375 Sodium:dicarboxylate symporter family 0.0002 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 0.0002 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0002 PF00490 Delta-aminolevulinic acid dehydratase 0.0002 PF00039 Fibronectin type I domain 0.0002 PF01490 Transmembrane amino acid transporter protein 0.0002 PF00258 Flavodoxin 0.0002 PF00667 FAD binding domain 0.0002 PF00764 Arginosuccinate synthase 0.0002 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0001 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0001 PF00458 WHEP-TRS domain 0.0001 PF00255 Glutathione peroxidase 0.0001 PF04960 Glutaminase 0.0001 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0001 PF07648 Kazal-type serine protease inhibitor domain SUB492 C-N:C-[#1] 0.0403 PF00227 Proteasome subunit 0.0056 PF01048 Phosphorylase superfamily 0.0047 PF00069 Protein kinase domain 0.0045 PF00478 IMP dehydrogenase / GMP reductase domain 0.0042 PF00186 Dihydrofolate reductase 0.0036 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0030 PF00571 CBS domain 0.0029 PF00962 Adenosine/AMP deaminase 0.0024 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0023 PF00156 Phosphoribosyl transferase domain 0.0020 PF08240 Alcohol dehydrogenase GroES-like domain 0.0020 PF00107 Zinc-binding dehydrogenase 0.0019 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0018 PF00106 short chain dehydrogenase 0.0018 PF01590 GAF domain 0.0016 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0016 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0015 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0015 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0015 PF00858 Amiloride-sensitive sodium channel 0.0015 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0013 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0012 PF00171 Aldehyde dehydrogenase family 0.0012 PF00017 SH2 domain 0.0011 PF00018 SH3 domain 0.0011 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0011 PF01467 Cytidylyltransferase 0.0011 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0009 PF01122 Eukaryotic cobalamin-binding protein 0.0009 PF00501 AMP-binding enzyme 0.0009 PF08919 F-actin binding 0.0008 PF10397 Adenylosuccinate lyase C-terminus 0.0008 PF08996 DNA Polymerase alpha zinc finger 0.0008 PF03104 DNA polymerase family B, exonuclease domain 0.0008 PF12423 Kinesin protein 1B 0.0008 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0008 PF00498 FHA domain 0.0008 PF08676 MutL C terminal dimerisation domain 0.0008 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0008 PF01575 MaoC like domain 0.0008 PF01119 DNA mismatch repair protein, C-terminal domain 0.0008 PF02036 SCP-2 sterol transfer family 0.0008 PF01126 Heme oxygenase 0.0008 PF00136 DNA polymerase family B 0.0008 PF12473 Kinesin protein 0.0008 PF01652 Eukaryotic initiation factor 4E 0.0007 PF02223 Thymidylate kinase 0.0007 PF00821 Phosphoenolpyruvate carboxykinase 0.0007 PF00970 Oxidoreductase FAD-binding domain 0.0007 PF01230 HIT domain 0.0007 PF00225 Kinesin motor domain 0.0006 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0006 PF07966 A1 Propeptide 0.0006 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0006 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0006 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0006 PF02233 NAD(P), transhydrogenase beta subunit 0.0006 PF00689 Cation transporting ATPase, C-terminus 0.0006 PF00931 NB-ARC domain 0.0006 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0006 PF01808 AICARFT/IMPCHase bienzyme 0.0006 PF00071 Ras family 0.0006 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0006 PF00400 WD domain, G-beta repeat 0.0006 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0006 PF00690 Cation transporter/ATPase, N-terminus 0.0005 PF03308 ArgK protein 0.0005 PF01642 Methylmalonyl-CoA mutase 0.0005 PF00958 GMP synthase C terminal domain 0.0005 PF08515 Transforming growth factor beta type I GS-motif 0.0005 PF00702 haloacid dehalogenase-like hydrolase 0.0005 PF00676 Dehydrogenase E1 component 0.0005 PF01923 Cobalamin adenosyltransferase 0.0005 PF00390 Malic enzyme, N-terminal domain 0.0005 PF00317 Ribonucleotide reductase, all-alpha domain 0.0005 PF02867 Ribonucleotide reductase, barrel domain 0.0005 PF02525 Flavodoxin-like fold 0.0005 PF03770 Inositol polyphosphate kinase 0.0005 PF00378 Enoyl-CoA hydratase/isomerase family 0.0005 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF03949 Malic enzyme, NAD binding domain 0.0005 PF03477 ATP cone domain 0.0005 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0005 PF01064 Activin types I and II receptor domain 0.0004 PF00536 SAM domain (Sterile alpha motif), 0.0004 PF03073 TspO/MBR family 0.0004 PF00122 E1-E2 ATPase 0.0004 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0004 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0004 PF01404 Ephrin receptor ligand binding domain 0.0004 PF00248 Aldo/keto reductase family 0.0004 PF09027 GTPase binding 0.0004 PF02267 ADP-ribosyl cyclase 0.0004 PF11555 EGFR receptor inhibitor Mig-6 0.0004 PF00310 Glutamine amidotransferases class-II 0.0003 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0003 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0003 PF00206 Lyase 0.0003 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0003 PF00757 Furin-like cysteine rich region 0.0003 PF01068 ATP dependent DNA ligase domain 0.0003 PF02310 B12 binding domain 0.0003 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0003 PF04679 ATP dependent DNA ligase C terminal region 0.0003 PF00025 ADP-ribosylation factor family 0.0003 PF03024 Folate receptor family 0.0003 PF00334 Nucleoside diphosphate kinase 0.0003 PF01030 Receptor L domain 0.0003 PF05347 Complex 1 protein (LYR family), 0.0003 PF00042 Globin 0.0002 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0002 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0002 PF00533 BRCA1 C Terminus (BRCT), domain 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF03530 Calcium-activated SK potassium channel 0.0002 PF05406 WGR domain 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0002 PF00005 ABC transporter 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF08063 PADR1 (NUC008), domain 0.0002 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF02779 Transketolase, pyrimidine binding domain 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF00794 PI3-kinase family, ras-binding domain 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF02888 Calmodulin binding domain 0.0002 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0002 PF01916 Deoxyhypusine synthase 0.0001 PF10531 SLBB domain 0.0001 PF01591 6-phosphofructo-2-kinase 0.0001 PF00291 Pyridoxal-phosphate dependent enzyme 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF00899 ThiF family 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF00629 MAM domain 0.0001 PF00012 Hsp70 protein 0.0001 PF10276 Zinc-finger domain 0.0001 PF00615 Regulator of G protein signaling domain 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF00300 Phosphoglycerate mutase family 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF01747 ATP-sulfurylase 0.0001 PF00026 Eukaryotic aspartyl protease 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF02173 pKID domain 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF02817 e3 binding domain 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF01582 TIR domain 0.0001 PF01583 Adenylylsulphate kinase 0.0001 PF02142 MGS-like domain 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF02793 Hormone receptor domain 0.0001 PF08544 GHMP kinases C terminal 0.0001 PF01434 Peptidase family M41 0.0001 PF01017 STAT protein, all-alpha domain 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF02196 Raf-like Ras-binding domain 0.0001 PF00316 Fructose-1-6-bisphosphatase 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF00221 Phenylalanine and histidine ammonia-lyase 0.0001 PF02803 Thiolase, C-terminal domain 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF02772 S-adenosylmethionine synthetase, central domain 0.0001 PF00343 Carbohydrate phosphorylase 0.0001 PF00183 Hsp90 protein 0.0001 PF12062 heparan sulfate-N-deacetylase 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF01835 MG2 domain 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF01687 Riboflavin kinase 0.0001 PF02037 SAP domain 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF06212 GRIM-19 protein 0.0001 PF02493 MORN repeat 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF00108 Thiolase, N-terminal domain 0.0001 PF02865 STAT protein, protein interaction domain 0.0001 PF02864 STAT protein, DNA binding domain 0.0001 PF00002 7 transmembrane receptor (Secretin family), 0.0001 PF00004 ATPase family associated with various cellular activities (AAA), 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF10509 Galactokinase galactose-binding signature 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF00856 SET domain 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF00439 Bromodomain 0.0001 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0001 PF08040 MNLL subunit 0.0001 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF00288 GHMP kinases N terminal domain 0.0001 PF00287 Sodium / potassium ATPase beta chain SUB374 C(~H)(:N) 0.0402 PF00227 Proteasome subunit 0.0056 PF01048 Phosphorylase superfamily 0.0047 PF00069 Protein kinase domain 0.0045 PF00478 IMP dehydrogenase / GMP reductase domain 0.0042 PF00186 Dihydrofolate reductase 0.0035 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0030 PF00571 CBS domain 0.0029 PF00962 Adenosine/AMP deaminase 0.0024 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0023 PF00156 Phosphoribosyl transferase domain 0.0020 PF08240 Alcohol dehydrogenase GroES-like domain 0.0020 PF00107 Zinc-binding dehydrogenase 0.0019 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0018 PF00106 short chain dehydrogenase 0.0018 PF01590 GAF domain 0.0016 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0016 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0015 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0015 PF00858 Amiloride-sensitive sodium channel 0.0015 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0015 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0013 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0012 PF00017 SH2 domain 0.0012 PF00171 Aldehyde dehydrogenase family 0.0011 PF01467 Cytidylyltransferase 0.0011 PF00018 SH3 domain 0.0011 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0011 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0009 PF08919 F-actin binding 0.0009 PF00501 AMP-binding enzyme 0.0009 PF01122 Eukaryotic cobalamin-binding protein 0.0008 PF00136 DNA polymerase family B 0.0008 PF12473 Kinesin protein 0.0008 PF08676 MutL C terminal dimerisation domain 0.0008 PF10397 Adenylosuccinate lyase C-terminus 0.0008 PF12423 Kinesin protein 1B 0.0008 PF01575 MaoC like domain 0.0008 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0008 PF01119 DNA mismatch repair protein, C-terminal domain 0.0008 PF01126 Heme oxygenase 0.0008 PF02036 SCP-2 sterol transfer family 0.0008 PF08996 DNA Polymerase alpha zinc finger 0.0008 PF03104 DNA polymerase family B, exonuclease domain 0.0008 PF00498 FHA domain 0.0008 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0007 PF01652 Eukaryotic initiation factor 4E 0.0007 PF00821 Phosphoenolpyruvate carboxykinase 0.0007 PF02223 Thymidylate kinase 0.0007 PF00225 Kinesin motor domain 0.0007 PF01230 HIT domain 0.0007 PF00970 Oxidoreductase FAD-binding domain 0.0006 PF00689 Cation transporting ATPase, C-terminus 0.0006 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0006 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0006 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0006 PF00400 WD domain, G-beta repeat 0.0006 PF00071 Ras family 0.0006 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0006 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0006 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0006 PF00690 Cation transporter/ATPase, N-terminus 0.0006 PF07966 A1 Propeptide 0.0006 PF01808 AICARFT/IMPCHase bienzyme 0.0006 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0006 PF02233 NAD(P), transhydrogenase beta subunit 0.0006 PF00931 NB-ARC domain 0.0005 PF00702 haloacid dehalogenase-like hydrolase 0.0005 PF08515 Transforming growth factor beta type I GS-motif 0.0005 PF03477 ATP cone domain 0.0005 PF02867 Ribonucleotide reductase, barrel domain 0.0005 PF00958 GMP synthase C terminal domain 0.0005 PF01642 Methylmalonyl-CoA mutase 0.0005 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0005 PF00390 Malic enzyme, N-terminal domain 0.0005 PF01923 Cobalamin adenosyltransferase 0.0005 PF02525 Flavodoxin-like fold 0.0005 PF01064 Activin types I and II receptor domain 0.0005 PF00378 Enoyl-CoA hydratase/isomerase family 0.0005 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF03770 Inositol polyphosphate kinase 0.0005 PF00317 Ribonucleotide reductase, all-alpha domain 0.0005 PF03308 ArgK protein 0.0005 PF00676 Dehydrogenase E1 component 0.0005 PF03949 Malic enzyme, NAD binding domain 0.0004 PF00310 Glutamine amidotransferases class-II 0.0004 PF00248 Aldo/keto reductase family 0.0004 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0004 PF01404 Ephrin receptor ligand binding domain 0.0004 PF11555 EGFR receptor inhibitor Mig-6 0.0004 PF02267 ADP-ribosyl cyclase 0.0004 PF00122 E1-E2 ATPase 0.0004 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0004 PF03073 TspO/MBR family 0.0004 PF00536 SAM domain (Sterile alpha motif), 0.0004 PF09027 GTPase binding 0.0003 PF00757 Furin-like cysteine rich region 0.0003 PF01068 ATP dependent DNA ligase domain 0.0003 PF00042 Globin 0.0003 PF04679 ATP dependent DNA ligase C terminal region 0.0003 PF00206 Lyase 0.0003 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0003 PF03024 Folate receptor family 0.0003 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0003 PF02310 B12 binding domain 0.0003 PF01030 Receptor L domain 0.0003 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0003 PF05347 Complex 1 protein (LYR family), 0.0003 PF00025 ADP-ribosylation factor family 0.0003 PF00334 Nucleoside diphosphate kinase 0.0003 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0002 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF02779 Transketolase, pyrimidine binding domain 0.0002 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0002 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0002 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0002 PF05406 WGR domain 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0002 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF00794 PI3-kinase family, ras-binding domain 0.0002 PF00533 BRCA1 C Terminus (BRCT), domain 0.0002 PF02888 Calmodulin binding domain 0.0002 PF03530 Calcium-activated SK potassium channel 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF08063 PADR1 (NUC008), domain 0.0002 PF00005 ABC transporter 0.0002 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0002 PF01916 Deoxyhypusine synthase 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0001 PF00629 MAM domain 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF00287 Sodium / potassium ATPase beta chain 0.0001 PF00288 GHMP kinases N terminal domain 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF02793 Hormone receptor domain 0.0001 PF01835 MG2 domain 0.0001 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF00291 Pyridoxal-phosphate dependent enzyme 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF00004 ATPase family associated with various cellular activities (AAA), 0.0001 PF00439 Bromodomain 0.0001 PF00012 Hsp70 protein 0.0001 PF00002 7 transmembrane receptor (Secretin family), 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF00856 SET domain 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF08040 MNLL subunit 0.0001 PF02493 MORN repeat 0.0001 PF02865 STAT protein, protein interaction domain 0.0001 PF02864 STAT protein, DNA binding domain 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF01687 Riboflavin kinase 0.0001 PF00108 Thiolase, N-terminal domain 0.0001 PF02196 Raf-like Ras-binding domain 0.0001 PF02173 pKID domain 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF08544 GHMP kinases C terminal 0.0001 PF12062 heparan sulfate-N-deacetylase 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF02803 Thiolase, C-terminal domain 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF01583 Adenylylsulphate kinase 0.0001 PF01582 TIR domain 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF10276 Zinc-finger domain 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0001 PF10509 Galactokinase galactose-binding signature 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF02142 MGS-like domain 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF00343 Carbohydrate phosphorylase 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF00221 Phenylalanine and histidine ammonia-lyase 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF01591 6-phosphofructo-2-kinase 0.0001 PF02037 SAP domain 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF00300 Phosphoglycerate mutase family 0.0001 PF00615 Regulator of G protein signaling domain 0.0001 PF02772 S-adenosylmethionine synthetase, central domain 0.0001 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF01747 ATP-sulfurylase 0.0001 PF00183 Hsp90 protein 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF00026 Eukaryotic aspartyl protease 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF00899 ThiF family 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF00316 Fructose-1-6-bisphosphatase 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF06212 GRIM-19 protein 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF01434 Peptidase family M41 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF01017 STAT protein, all-alpha domain 0.0001 PF10531 SLBB domain 0.0001 PF02817 e3 binding domain SUB522 C:N-C-[#1] 0.0393 PF00227 Proteasome subunit 0.0055 PF01048 Phosphorylase superfamily 0.0046 PF00069 Protein kinase domain 0.0044 PF00478 IMP dehydrogenase / GMP reductase domain 0.0041 PF00186 Dihydrofolate reductase 0.0035 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0029 PF00962 Adenosine/AMP deaminase 0.0029 PF00571 CBS domain 0.0024 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0023 PF00156 Phosphoribosyl transferase domain 0.0020 PF08240 Alcohol dehydrogenase GroES-like domain 0.0019 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0019 PF00107 Zinc-binding dehydrogenase 0.0018 PF00106 short chain dehydrogenase 0.0018 PF01590 GAF domain 0.0016 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0016 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0015 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0015 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0015 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0014 PF00858 Amiloride-sensitive sodium channel 0.0012 PF00171 Aldehyde dehydrogenase family 0.0012 PF00017 SH2 domain 0.0012 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0011 PF01467 Cytidylyltransferase 0.0011 PF00018 SH3 domain 0.0010 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0010 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0009 PF00501 AMP-binding enzyme 0.0009 PF08919 F-actin binding 0.0009 PF01122 Eukaryotic cobalamin-binding protein 0.0008 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0008 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0007 PF01119 DNA mismatch repair protein, C-terminal domain 0.0007 PF00136 DNA polymerase family B 0.0007 PF00498 FHA domain 0.0007 PF02036 SCP-2 sterol transfer family 0.0007 PF01575 MaoC like domain 0.0007 PF12423 Kinesin protein 1B 0.0007 PF01652 Eukaryotic initiation factor 4E 0.0007 PF00970 Oxidoreductase FAD-binding domain 0.0007 PF08676 MutL C terminal dimerisation domain 0.0007 PF10397 Adenylosuccinate lyase C-terminus 0.0007 PF02223 Thymidylate kinase 0.0007 PF01126 Heme oxygenase 0.0007 PF12473 Kinesin protein 0.0007 PF01230 HIT domain 0.0007 PF03104 DNA polymerase family B, exonuclease domain 0.0007 PF00821 Phosphoenolpyruvate carboxykinase 0.0007 PF08996 DNA Polymerase alpha zinc finger 0.0006 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0006 PF00690 Cation transporter/ATPase, N-terminus 0.0006 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0006 PF01808 AICARFT/IMPCHase bienzyme 0.0006 PF00689 Cation transporting ATPase, C-terminus 0.0006 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0006 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0006 PF00225 Kinesin motor domain 0.0006 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0006 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0006 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0006 PF02233 NAD(P), transhydrogenase beta subunit 0.0006 PF07966 A1 Propeptide 0.0006 PF00400 WD domain, G-beta repeat 0.0006 PF00931 NB-ARC domain 0.0006 PF00071 Ras family 0.0005 PF00378 Enoyl-CoA hydratase/isomerase family 0.0005 PF02867 Ribonucleotide reductase, barrel domain 0.0005 PF00958 GMP synthase C terminal domain 0.0005 PF00317 Ribonucleotide reductase, all-alpha domain 0.0005 PF01923 Cobalamin adenosyltransferase 0.0005 PF03477 ATP cone domain 0.0005 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0005 PF00676 Dehydrogenase E1 component 0.0005 PF01064 Activin types I and II receptor domain 0.0005 PF02525 Flavodoxin-like fold 0.0005 PF03949 Malic enzyme, NAD binding domain 0.0005 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF03770 Inositol polyphosphate kinase 0.0005 PF00390 Malic enzyme, N-terminal domain 0.0005 PF03308 ArgK protein 0.0005 PF00702 haloacid dehalogenase-like hydrolase 0.0005 PF01642 Methylmalonyl-CoA mutase 0.0005 PF08515 Transforming growth factor beta type I GS-motif 0.0004 PF03073 TspO/MBR family 0.0004 PF00122 E1-E2 ATPase 0.0004 PF02267 ADP-ribosyl cyclase 0.0004 PF11555 EGFR receptor inhibitor Mig-6 0.0004 PF09027 GTPase binding 0.0004 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0004 PF00310 Glutamine amidotransferases class-II 0.0004 PF00248 Aldo/keto reductase family 0.0004 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF01030 Receptor L domain 0.0003 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0003 PF04679 ATP dependent DNA ligase C terminal region 0.0003 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0003 PF01404 Ephrin receptor ligand binding domain 0.0003 PF00536 SAM domain (Sterile alpha motif), 0.0003 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0003 PF00025 ADP-ribosylation factor family 0.0003 PF00757 Furin-like cysteine rich region 0.0003 PF00042 Globin 0.0003 PF02310 B12 binding domain 0.0003 PF05347 Complex 1 protein (LYR family), 0.0003 PF00334 Nucleoside diphosphate kinase 0.0003 PF03024 Folate receptor family 0.0003 PF01068 ATP dependent DNA ligase domain 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF01916 Deoxyhypusine synthase 0.0002 PF03530 Calcium-activated SK potassium channel 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0002 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0002 PF00206 Lyase 0.0002 PF00794 PI3-kinase family, ras-binding domain 0.0002 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF02888 Calmodulin binding domain 0.0002 PF08063 PADR1 (NUC008), domain 0.0002 PF02779 Transketolase, pyrimidine binding domain 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF00005 ABC transporter 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0002 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0002 PF05406 WGR domain 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0002 PF00533 BRCA1 C Terminus (BRCT), domain 0.0001 PF00288 GHMP kinases N terminal domain 0.0001 PF00287 Sodium / potassium ATPase beta chain 0.0001 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF01434 Peptidase family M41 0.0001 PF00221 Phenylalanine and histidine ammonia-lyase 0.0001 PF00012 Hsp70 protein 0.0001 PF00108 Thiolase, N-terminal domain 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF01747 ATP-sulfurylase 0.0001 PF01591 6-phosphofructo-2-kinase 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF10509 Galactokinase galactose-binding signature 0.0001 PF10531 SLBB domain 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF01582 TIR domain 0.0001 PF01583 Adenylylsulphate kinase 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF00856 SET domain 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0001 PF02864 STAT protein, DNA binding domain 0.0001 PF02865 STAT protein, protein interaction domain 0.0001 PF00004 ATPase family associated with various cellular activities (AAA), 0.0001 PF00002 7 transmembrane receptor (Secretin family), 0.0001 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0001 PF02142 MGS-like domain 0.0001 PF00439 Bromodomain 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0001 PF02772 S-adenosylmethionine synthetase, central domain 0.0001 PF02037 SAP domain 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF02173 pKID domain 0.0001 PF00343 Carbohydrate phosphorylase 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF12062 heparan sulfate-N-deacetylase 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF02803 Thiolase, C-terminal domain 0.0001 PF01017 STAT protein, all-alpha domain 0.0001 PF02196 Raf-like Ras-binding domain 0.0001 PF08544 GHMP kinases C terminal 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF02793 Hormone receptor domain 0.0001 PF01687 Riboflavin kinase 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF00026 Eukaryotic aspartyl protease 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF01835 MG2 domain 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF00316 Fructose-1-6-bisphosphatase 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF02817 e3 binding domain 0.0001 PF08040 MNLL subunit 0.0001 PF00183 Hsp90 protein 0.0001 PF00615 Regulator of G protein signaling domain 0.0001 PF02493 MORN repeat 0.0001 PF10276 Zinc-finger domain 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF00899 ThiF family 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF00300 Phosphoglycerate mutase family 0.0001 PF00291 Pyridoxal-phosphate dependent enzyme 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF00629 MAM domain 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF06212 GRIM-19 protein SUB397 N(~C)(:C) 0.0392 PF00227 Proteasome subunit 0.0159 PF00069 Protein kinase domain 0.0158 PF03073 TspO/MBR family 0.0152 PF01048 Phosphorylase superfamily 0.0146 PF00186 Dihydrofolate reductase 0.0107 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0098 PF00478 IMP dehydrogenase / GMP reductase domain 0.0071 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0067 PF00571 CBS domain 0.0058 PF00962 Adenosine/AMP deaminase 0.0041 PF01590 GAF domain 0.0040 PF03953 Tubulin C-terminal domain 0.0040 PF00091 Tubulin/FtsZ family, GTPase domain 0.0038 PF00156 Phosphoribosyl transferase domain 0.0034 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0034 PF08240 Alcohol dehydrogenase GroES-like domain 0.0034 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0033 PF01126 Heme oxygenase 0.0031 PF00107 Zinc-binding dehydrogenase 0.0028 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0027 PF00017 SH2 domain 0.0025 PF00858 Amiloride-sensitive sodium channel 0.0023 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0023 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0022 PF00018 SH3 domain 0.0022 PF00106 short chain dehydrogenase 0.0016 PF00042 Globin 0.0015 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0015 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0015 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0012 PF08919 F-actin binding 0.0012 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0012 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0012 PF00171 Aldehyde dehydrogenase family 0.0011 PF01467 Cytidylyltransferase 0.0010 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0010 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0009 PF01122 Eukaryotic cobalamin-binding protein 0.0009 PF02267 ADP-ribosyl cyclase 0.0009 PF00501 AMP-binding enzyme 0.0008 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0008 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0007 PF00970 Oxidoreductase FAD-binding domain 0.0007 PF01575 MaoC like domain 0.0007 PF00821 Phosphoenolpyruvate carboxykinase 0.0007 PF02223 Thymidylate kinase 0.0007 PF08676 MutL C terminal dimerisation domain 0.0007 PF00498 FHA domain 0.0007 PF00136 DNA polymerase family B 0.0007 PF12423 Kinesin protein 1B 0.0007 PF01230 HIT domain 0.0007 PF08996 DNA Polymerase alpha zinc finger 0.0007 PF01652 Eukaryotic initiation factor 4E 0.0007 PF01119 DNA mismatch repair protein, C-terminal domain 0.0007 PF03104 DNA polymerase family B, exonuclease domain 0.0007 PF12473 Kinesin protein 0.0007 PF02036 SCP-2 sterol transfer family 0.0007 PF10397 Adenylosuccinate lyase C-terminus 0.0007 PF00343 Carbohydrate phosphorylase 0.0006 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0006 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0006 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0006 PF00225 Kinesin motor domain 0.0006 PF00931 NB-ARC domain 0.0006 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0006 PF07966 A1 Propeptide 0.0006 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0006 PF00071 Ras family 0.0006 PF00690 Cation transporter/ATPase, N-terminus 0.0006 PF00689 Cation transporting ATPase, C-terminus 0.0006 PF02233 NAD(P), transhydrogenase beta subunit 0.0006 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0006 PF01808 AICARFT/IMPCHase bienzyme 0.0006 PF00400 WD domain, G-beta repeat 0.0006 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0005 PF00317 Ribonucleotide reductase, all-alpha domain 0.0005 PF03477 ATP cone domain 0.0005 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0005 PF01642 Methylmalonyl-CoA mutase 0.0005 PF03949 Malic enzyme, NAD binding domain 0.0005 PF00378 Enoyl-CoA hydratase/isomerase family 0.0005 PF08515 Transforming growth factor beta type I GS-motif 0.0005 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF00676 Dehydrogenase E1 component 0.0005 PF00702 haloacid dehalogenase-like hydrolase 0.0005 PF00390 Malic enzyme, N-terminal domain 0.0005 PF01064 Activin types I and II receptor domain 0.0005 PF03770 Inositol polyphosphate kinase 0.0005 PF02867 Ribonucleotide reductase, barrel domain 0.0005 PF01923 Cobalamin adenosyltransferase 0.0005 PF03308 ArgK protein 0.0005 PF02525 Flavodoxin-like fold 0.0005 PF00958 GMP synthase C terminal domain 0.0004 PF09027 GTPase binding 0.0004 PF00122 E1-E2 ATPase 0.0004 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0004 PF00005 ABC transporter 0.0004 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0004 PF11555 EGFR receptor inhibitor Mig-6 0.0004 PF00248 Aldo/keto reductase family 0.0004 PF00310 Glutamine amidotransferases class-II 0.0003 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0003 PF00757 Furin-like cysteine rich region 0.0003 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0003 PF01404 Ephrin receptor ligand binding domain 0.0003 PF00025 ADP-ribosylation factor family 0.0003 PF03024 Folate receptor family 0.0003 PF00536 SAM domain (Sterile alpha motif), 0.0003 PF04679 ATP dependent DNA ligase C terminal region 0.0003 PF00334 Nucleoside diphosphate kinase 0.0003 PF01068 ATP dependent DNA ligase domain 0.0003 PF02310 B12 binding domain 0.0003 PF01030 Receptor L domain 0.0003 PF05347 Complex 1 protein (LYR family), 0.0003 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0002 PF01916 Deoxyhypusine synthase 0.0002 PF00206 Lyase 0.0002 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF00794 PI3-kinase family, ras-binding domain 0.0002 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF02779 Transketolase, pyrimidine binding domain 0.0002 PF03530 Calcium-activated SK potassium channel 0.0002 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0002 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0002 PF02888 Calmodulin binding domain 0.0002 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0002 PF00533 BRCA1 C Terminus (BRCT), domain 0.0002 PF08063 PADR1 (NUC008), domain 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF05406 WGR domain 0.0001 PF06212 GRIM-19 protein 0.0001 PF02142 MGS-like domain 0.0001 PF00108 Thiolase, N-terminal domain 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF00856 SET domain 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF01687 Riboflavin kinase 0.0001 PF08040 MNLL subunit 0.0001 PF10509 Galactokinase galactose-binding signature 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF00291 Pyridoxal-phosphate dependent enzyme 0.0001 PF00002 7 transmembrane receptor (Secretin family), 0.0001 PF00004 ATPase family associated with various cellular activities (AAA), 0.0001 PF02493 MORN repeat 0.0001 PF01835 MG2 domain 0.0001 PF10531 SLBB domain 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF00221 Phenylalanine and histidine ammonia-lyase 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF00316 Fructose-1-6-bisphosphatase 0.0001 PF08544 GHMP kinases C terminal 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF01591 6-phosphofructo-2-kinase 0.0001 PF01434 Peptidase family M41 0.0001 PF02865 STAT protein, protein interaction domain 0.0001 PF02864 STAT protein, DNA binding domain 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF01017 STAT protein, all-alpha domain 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF02173 pKID domain 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF00026 Eukaryotic aspartyl protease 0.0001 PF02803 Thiolase, C-terminal domain 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF00012 Hsp70 protein 0.0001 PF00287 Sodium / potassium ATPase beta chain 0.0001 PF00288 GHMP kinases N terminal domain 0.0001 PF00629 MAM domain 0.0001 PF02817 e3 binding domain 0.0001 PF00183 Hsp90 protein 0.0001 PF10276 Zinc-finger domain 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF02772 S-adenosylmethionine synthetase, central domain 0.0001 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF12062 heparan sulfate-N-deacetylase 0.0001 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0001 PF00300 Phosphoglycerate mutase family 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF02196 Raf-like Ras-binding domain 0.0001 PF02037 SAP domain 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF01747 ATP-sulfurylase 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF00899 ThiF family 0.0001 PF00615 Regulator of G protein signaling domain 0.0001 PF00439 Bromodomain 0.0001 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0001 PF02793 Hormone receptor domain 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF01582 TIR domain 0.0001 PF01583 Adenylylsulphate kinase SUB483 C:N-C:C 0.0391 PF00227 Proteasome subunit 0.0150 PF00069 Protein kinase domain 0.0145 PF03073 TspO/MBR family 0.0143 PF01048 Phosphorylase superfamily 0.0137 PF00186 Dihydrofolate reductase 0.0101 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0093 PF00478 IMP dehydrogenase / GMP reductase domain 0.0067 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0064 PF00571 CBS domain 0.0055 PF00962 Adenosine/AMP deaminase 0.0039 PF01590 GAF domain 0.0036 PF03953 Tubulin C-terminal domain 0.0036 PF00156 Phosphoribosyl transferase domain 0.0036 PF00091 Tubulin/FtsZ family, GTPase domain 0.0033 PF08240 Alcohol dehydrogenase GroES-like domain 0.0031 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0031 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0031 PF01126 Heme oxygenase 0.0030 PF00107 Zinc-binding dehydrogenase 0.0027 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0025 PF00017 SH2 domain 0.0024 PF00858 Amiloride-sensitive sodium channel 0.0022 PF00106 short chain dehydrogenase 0.0022 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0022 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0021 PF00018 SH3 domain 0.0015 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0015 PF00042 Globin 0.0015 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0015 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0012 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0012 PF08919 F-actin binding 0.0012 PF00171 Aldehyde dehydrogenase family 0.0011 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0011 PF01467 Cytidylyltransferase 0.0010 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0010 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0009 PF00501 AMP-binding enzyme 0.0009 PF01122 Eukaryotic cobalamin-binding protein 0.0009 PF02267 ADP-ribosyl cyclase 0.0008 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0008 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0007 PF03104 DNA polymerase family B, exonuclease domain 0.0007 PF01652 Eukaryotic initiation factor 4E 0.0007 PF01575 MaoC like domain 0.0007 PF08676 MutL C terminal dimerisation domain 0.0007 PF02223 Thymidylate kinase 0.0007 PF00970 Oxidoreductase FAD-binding domain 0.0007 PF12473 Kinesin protein 0.0007 PF00821 Phosphoenolpyruvate carboxykinase 0.0007 PF01230 HIT domain 0.0007 PF08996 DNA Polymerase alpha zinc finger 0.0007 PF00498 FHA domain 0.0007 PF10397 Adenylosuccinate lyase C-terminus 0.0007 PF12423 Kinesin protein 1B 0.0007 PF02036 SCP-2 sterol transfer family 0.0007 PF01119 DNA mismatch repair protein, C-terminal domain 0.0007 PF00136 DNA polymerase family B 0.0007 PF00343 Carbohydrate phosphorylase 0.0006 PF01808 AICARFT/IMPCHase bienzyme 0.0006 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0006 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0006 PF00071 Ras family 0.0006 PF02233 NAD(P), transhydrogenase beta subunit 0.0006 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0006 PF00690 Cation transporter/ATPase, N-terminus 0.0006 PF07966 A1 Propeptide 0.0006 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0006 PF00931 NB-ARC domain 0.0006 PF00225 Kinesin motor domain 0.0006 PF00400 WD domain, G-beta repeat 0.0006 PF00689 Cation transporting ATPase, C-terminus 0.0006 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0006 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0006 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0005 PF00958 GMP synthase C terminal domain 0.0005 PF00317 Ribonucleotide reductase, all-alpha domain 0.0005 PF02867 Ribonucleotide reductase, barrel domain 0.0005 PF03770 Inositol polyphosphate kinase 0.0005 PF01064 Activin types I and II receptor domain 0.0005 PF00390 Malic enzyme, N-terminal domain 0.0005 PF02525 Flavodoxin-like fold 0.0005 PF08515 Transforming growth factor beta type I GS-motif 0.0005 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0005 PF03949 Malic enzyme, NAD binding domain 0.0005 PF03308 ArgK protein 0.0005 PF03477 ATP cone domain 0.0005 PF00702 haloacid dehalogenase-like hydrolase 0.0005 PF01642 Methylmalonyl-CoA mutase 0.0005 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF01923 Cobalamin adenosyltransferase 0.0005 PF00676 Dehydrogenase E1 component 0.0005 PF00378 Enoyl-CoA hydratase/isomerase family 0.0004 PF00005 ABC transporter 0.0004 PF00310 Glutamine amidotransferases class-II 0.0004 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0004 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0004 PF00248 Aldo/keto reductase family 0.0004 PF00122 E1-E2 ATPase 0.0003 PF01068 ATP dependent DNA ligase domain 0.0003 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0003 PF00025 ADP-ribosylation factor family 0.0003 PF11555 EGFR receptor inhibitor Mig-6 0.0003 PF00334 Nucleoside diphosphate kinase 0.0003 PF01404 Ephrin receptor ligand binding domain 0.0003 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0003 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0003 PF05347 Complex 1 protein (LYR family), 0.0003 PF00536 SAM domain (Sterile alpha motif), 0.0003 PF09027 GTPase binding 0.0003 PF04679 ATP dependent DNA ligase C terminal region 0.0003 PF01030 Receptor L domain 0.0003 PF02310 B12 binding domain 0.0003 PF00757 Furin-like cysteine rich region 0.0003 PF03024 Folate receptor family 0.0002 PF01916 Deoxyhypusine synthase 0.0002 PF00206 Lyase 0.0002 PF02779 Transketolase, pyrimidine binding domain 0.0002 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0002 PF02888 Calmodulin binding domain 0.0002 PF03530 Calcium-activated SK potassium channel 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0002 PF00794 PI3-kinase family, ras-binding domain 0.0002 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF00533 BRCA1 C Terminus (BRCT), domain 0.0002 PF08063 PADR1 (NUC008), domain 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0002 PF05406 WGR domain 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0001 PF01835 MG2 domain 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF10509 Galactokinase galactose-binding signature 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF00629 MAM domain 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF08544 GHMP kinases C terminal 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF01687 Riboflavin kinase 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF02817 e3 binding domain 0.0001 PF00108 Thiolase, N-terminal domain 0.0001 PF00439 Bromodomain 0.0001 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF00856 SET domain 0.0001 PF10531 SLBB domain 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF08040 MNLL subunit 0.0001 PF06212 GRIM-19 protein 0.0001 PF00026 Eukaryotic aspartyl protease 0.0001 PF12062 heparan sulfate-N-deacetylase 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF00300 Phosphoglycerate mutase family 0.0001 PF02793 Hormone receptor domain 0.0001 PF01434 Peptidase family M41 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF00899 ThiF family 0.0001 PF00288 GHMP kinases N terminal domain 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF00287 Sodium / potassium ATPase beta chain 0.0001 PF00221 Phenylalanine and histidine ammonia-lyase 0.0001 PF00183 Hsp90 protein 0.0001 PF01747 ATP-sulfurylase 0.0001 PF10276 Zinc-finger domain 0.0001 PF00291 Pyridoxal-phosphate dependent enzyme 0.0001 PF02493 MORN repeat 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF01591 6-phosphofructo-2-kinase 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF02865 STAT protein, protein interaction domain 0.0001 PF02864 STAT protein, DNA binding domain 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF00615 Regulator of G protein signaling domain 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0001 PF01017 STAT protein, all-alpha domain 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0001 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0001 PF02772 S-adenosylmethionine synthetase, central domain 0.0001 PF02173 pKID domain 0.0001 PF02037 SAP domain 0.0001 PF00004 ATPase family associated with various cellular activities (AAA), 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF00002 7 transmembrane receptor (Secretin family), 0.0001 PF00316 Fructose-1-6-bisphosphatase 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF02142 MGS-like domain 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF02803 Thiolase, C-terminal domain 0.0001 PF02196 Raf-like Ras-binding domain 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF00012 Hsp70 protein 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF01582 TIR domain 0.0001 PF01583 Adenylylsulphate kinase SUB644 [#1]-C-C-N-[#1] 0.0389 PF02798 Glutathione S-transferase, N-terminal domain 0.0380 PF00043 Glutathione S-transferase, C-terminal domain 0.0230 PF00255 Glutathione peroxidase 0.0185 PF05649 Peptidase family M13 0.0185 PF01431 Peptidase family M13 0.0161 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0130 PF01124 MAPEG family 0.0121 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0115 PF03953 Tubulin C-terminal domain 0.0115 PF00091 Tubulin/FtsZ family, GTPase domain 0.0112 PF01401 Angiotensin-converting enzyme 0.0105 PF09396 Thrombin light chain 0.0102 PF03199 Eukaryotic glutathione synthase 0.0102 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0078 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0077 PF01323 DSBA-like thioredoxin domain 0.0070 PF00656 Caspase domain 0.0068 PF08983 Domain of unknown function (DUF1856), 0.0065 PF00303 Thymidylate synthase 0.0060 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0057 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0056 PF00462 Glutaredoxin 0.0053 PF07722 Peptidase C26 0.0046 PF01406 tRNA synthetases class I (C), catalytic domain 0.0045 PF05995 Cysteine dioxygenase type I 0.0044 PF00756 Putative esterase 0.0044 PF01019 Gamma-glutamyltranspeptidase 0.0040 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0040 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0038 PF00619 Caspase recruitment domain 0.0037 PF03074 Glutamate-cysteine ligase 0.0026 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0025 PF00439 Bromodomain 0.0025 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0023 PF06617 M-phase inducer phosphatase 0.0023 PF00581 Rhodanese-like domain 0.0020 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0020 PF03002 Somatostatin/Cortistatin family 0.0019 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0017 PF00778 DIX domain 0.0017 PF08833 Axin beta-catenin binding domain 0.0017 PF00806 Pumilio-family RNA binding repeat 0.0017 PF00085 Thioredoxin 0.0016 PF00822 PMP-22/EMP/MP20/Claudin family 0.0015 PF00265 Thymidine kinase 0.0014 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0014 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0012 PF00931 NB-ARC domain 0.0012 PF00400 WD domain, G-beta repeat 0.0012 PF00342 Phosphoglucose isomerase 0.0009 PF00002 7 transmembrane receptor (Secretin family), 0.0009 PF02793 Hormone receptor domain 0.0007 PF01268 Formate--tetrahydrofolate ligase 0.0004 PF10420 Cytokine interleukin-12p40 C-terminus 0.0004 PF02769 AIR synthase related protein, C-terminal domain 0.0004 PF00586 AIR synthase related protein, N-terminal domain 0.0003 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0003 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0002 PF00045 Hemopexin 0.0002 PF00108 Thiolase, N-terminal domain 0.0002 PF01471 Putative peptidoglycan binding domain 0.0002 PF02803 Thiolase, C-terminal domain 0.0001 PF00551 Formyl transferase SUB450 C(-N)(=C) 0.0388 PF08070 DTHCT (NUC029), region 0.0388 PF00204 DNA gyrase B 0.0388 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0261 PF00186 Dihydrofolate reductase 0.0236 PF01048 Phosphorylase superfamily 0.0227 PF00001 7 transmembrane receptor (rhodopsin family), 0.0208 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0206 PF00069 Protein kinase domain 0.0153 PF00478 IMP dehydrogenase / GMP reductase domain 0.0113 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0091 PF08240 Alcohol dehydrogenase GroES-like domain 0.0088 PF00571 CBS domain 0.0080 PF00107 Zinc-binding dehydrogenase 0.0071 PF00962 Adenosine/AMP deaminase 0.0070 PF00017 SH2 domain 0.0068 PF02223 Thymidylate kinase 0.0068 PF00018 SH3 domain 0.0061 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0059 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0059 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0054 PF00106 short chain dehydrogenase 0.0049 PF01590 GAF domain 0.0043 PF08919 F-actin binding 0.0042 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0034 PF00005 ABC transporter 0.0032 PF00858 Amiloride-sensitive sodium channel 0.0028 PF01467 Cytidylyltransferase 0.0027 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0027 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0027 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0024 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0022 PF00171 Aldehyde dehydrogenase family 0.0020 PF00156 Phosphoribosyl transferase domain 0.0019 PF03073 TspO/MBR family 0.0016 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0016 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0013 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0006 PF01687 Riboflavin kinase 0.0005 PF01061 ABC-2 type transporter 0.0005 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0005 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0004 PF02267 ADP-ribosyl cyclase 0.0003 PF00664 ABC transporter transmembrane region 0.0001 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0001 PF02036 SCP-2 sterol transfer family 0.0001 PF01575 MaoC like domain 0.0001 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain SUB390 C(:N)(:N) 0.0381 PF00186 Dihydrofolate reductase 0.0203 PF00069 Protein kinase domain 0.0170 PF00478 IMP dehydrogenase / GMP reductase domain 0.0149 PF08240 Alcohol dehydrogenase GroES-like domain 0.0134 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0132 PF00107 Zinc-binding dehydrogenase 0.0130 PF01048 Phosphorylase superfamily 0.0123 PF00106 short chain dehydrogenase 0.0112 PF00571 CBS domain 0.0085 PF00962 Adenosine/AMP deaminase 0.0082 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0082 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0081 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0081 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0081 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0069 PF00171 Aldehyde dehydrogenase family 0.0055 PF00018 SH3 domain 0.0055 PF00248 Aldo/keto reductase family 0.0052 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0052 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0049 PF02223 Thymidylate kinase 0.0045 PF00156 Phosphoribosyl transferase domain 0.0041 PF01122 Eukaryotic cobalamin-binding protein 0.0040 PF00017 SH2 domain 0.0038 PF00501 AMP-binding enzyme 0.0034 PF08919 F-actin binding 0.0030 PF01467 Cytidylyltransferase 0.0030 PF02310 B12 binding domain 0.0029 PF01642 Methylmalonyl-CoA mutase 0.0029 PF03308 ArgK protein 0.0029 PF01923 Cobalamin adenosyltransferase 0.0024 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0024 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0024 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0023 PF00225 Kinesin motor domain 0.0021 PF00970 Oxidoreductase FAD-binding domain 0.0021 PF01230 HIT domain 0.0020 PF03949 Malic enzyme, NAD binding domain 0.0020 PF12423 Kinesin protein 1B 0.0020 PF01575 MaoC like domain 0.0020 PF00390 Malic enzyme, N-terminal domain 0.0020 PF02036 SCP-2 sterol transfer family 0.0020 PF08676 MutL C terminal dimerisation domain 0.0020 PF12473 Kinesin protein 0.0020 PF00498 FHA domain 0.0020 PF01119 DNA mismatch repair protein, C-terminal domain 0.0019 PF03104 DNA polymerase family B, exonuclease domain 0.0019 PF08996 DNA Polymerase alpha zinc finger 0.0019 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0019 PF00136 DNA polymerase family B 0.0019 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0018 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0018 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0017 PF02233 NAD(P), transhydrogenase beta subunit 0.0016 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0016 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0016 PF00931 NB-ARC domain 0.0016 PF00400 WD domain, G-beta repeat 0.0014 PF02607 B12 binding domain 0.0014 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0014 PF00809 Pterin binding enzyme 0.0014 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0013 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0013 PF03770 Inositol polyphosphate kinase 0.0013 PF00258 Flavodoxin 0.0013 PF00431 CUB domain 0.0013 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0013 PF00667 FAD binding domain 0.0012 PF02867 Ribonucleotide reductase, barrel domain 0.0012 PF03477 ATP cone domain 0.0012 PF00317 Ribonucleotide reductase, all-alpha domain 0.0012 PF00175 Oxidoreductase NAD-binding domain 0.0011 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0011 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0009 PF07645 Calcium-binding EGF domain 0.0007 PF02574 Homocysteine S-methyltransferase 0.0007 PF01268 Formate--tetrahydrofolate ligase 0.0006 PF00757 Furin-like cysteine rich region 0.0006 PF01030 Receptor L domain 0.0005 PF00858 Amiloride-sensitive sodium channel 0.0005 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0005 PF00676 Dehydrogenase E1 component 0.0004 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0004 PF01064 Activin types I and II receptor domain 0.0004 PF00378 Enoyl-CoA hydratase/isomerase family 0.0004 PF08515 Transforming growth factor beta type I GS-motif 0.0003 PF01126 Heme oxygenase 0.0002 PF02267 ADP-ribosyl cyclase 0.0002 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0001 PF01403 Sema domain 0.0001 PF01437 Plexin repeat 0.0001 PF02525 Flavodoxin-like fold 0.0001 PF02779 Transketolase, pyrimidine binding domain 0.0001 PF01687 Riboflavin kinase 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF01833 IPT/TIG domain 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0001 PF00348 Polyprenyl synthetase 0.0001 PF00005 ABC transporter 0.0001 PF05347 Complex 1 protein (LYR family), 0.0001 PF00057 Low-density lipoprotein receptor domain class A 0.0001 PF00058 Low-density lipoprotein receptor repeat class B 0.0001 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0001 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0001 PF01652 Eukaryotic initiation factor 4E SUB393 N(~C)(~C)(~H) 0.0373 PF02798 Glutathione S-transferase, N-terminal domain 0.0364 PF00043 Glutathione S-transferase, C-terminal domain 0.0221 PF00255 Glutathione peroxidase 0.0178 PF01431 Peptidase family M13 0.0178 PF05649 Peptidase family M13 0.0155 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0125 PF01124 MAPEG family 0.0116 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0110 PF03953 Tubulin C-terminal domain 0.0110 PF00091 Tubulin/FtsZ family, GTPase domain 0.0107 PF01401 Angiotensin-converting enzyme 0.0101 PF09396 Thrombin light chain 0.0098 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0098 PF03199 Eukaryotic glutathione synthase 0.0075 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0074 PF01323 DSBA-like thioredoxin domain 0.0067 PF00656 Caspase domain 0.0066 PF08983 Domain of unknown function (DUF1856), 0.0062 PF00303 Thymidylate synthase 0.0058 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0054 PF00462 Glutaredoxin 0.0054 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0051 PF07722 Peptidase C26 0.0044 PF01406 tRNA synthetases class I (C), catalytic domain 0.0043 PF05995 Cysteine dioxygenase type I 0.0042 PF00756 Putative esterase 0.0042 PF01019 Gamma-glutamyltranspeptidase 0.0038 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0038 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0037 PF00619 Caspase recruitment domain 0.0035 PF03074 Glutamate-cysteine ligase 0.0025 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0024 PF00439 Bromodomain 0.0024 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0022 PF06617 M-phase inducer phosphatase 0.0022 PF00581 Rhodanese-like domain 0.0020 PF03002 Somatostatin/Cortistatin family 0.0019 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0019 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0017 PF00085 Thioredoxin 0.0016 PF08833 Axin beta-catenin binding domain 0.0016 PF00822 PMP-22/EMP/MP20/Claudin family 0.0016 PF00778 DIX domain 0.0016 PF00806 Pumilio-family RNA binding repeat 0.0014 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0014 PF00265 Thymidine kinase 0.0014 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0012 PF00400 WD domain, G-beta repeat 0.0012 PF00931 NB-ARC domain 0.0012 PF00342 Phosphoglucose isomerase 0.0009 PF00002 7 transmembrane receptor (Secretin family), 0.0009 PF02793 Hormone receptor domain 0.0006 PF01268 Formate--tetrahydrofolate ligase 0.0004 PF02769 AIR synthase related protein, C-terminal domain 0.0004 PF10420 Cytokine interleukin-12p40 C-terminus 0.0004 PF00586 AIR synthase related protein, N-terminal domain 0.0003 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0003 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0002 PF00045 Hemopexin 0.0002 PF00108 Thiolase, N-terminal domain 0.0002 PF01471 Putative peptidoglycan binding domain 0.0002 PF02803 Thiolase, C-terminal domain 0.0001 PF00551 Formyl transferase SUB756 Cc1c(C)cccc1 0.0370 PF00001 7 transmembrane receptor (rhodopsin family), 0.0206 PF00105 Zinc finger, C4 type (two domains), 0.0205 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0194 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0181 PF02159 Oestrogen receptor 0.0118 PF00209 Sodium:neurotransmitter symporter family 0.0081 PF03098 Animal haem peroxidase 0.0076 PF08070 DTHCT (NUC029), region 0.0076 PF00204 DNA gyrase B 0.0076 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0039 PF00091 Tubulin/FtsZ family, GTPase domain 0.0039 PF03953 Tubulin C-terminal domain 0.0039 PF00989 PAS fold 0.0032 PF09396 Thrombin light chain 0.0031 PF00027 Cyclic nucleotide-binding domain 0.0030 PF00005 ABC transporter 0.0027 PF00067 Cytochrome P450 0.0026 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0026 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0021 PF00664 ABC transporter transmembrane region 0.0011 PF00273 Serum albumin family 0.0011 PF02161 Progesterone receptor 0.0010 PF01593 Flavin containing amine oxidoreductase 0.0008 PF03073 TspO/MBR family 0.0007 PF12497 Estrogen receptor beta 0.0006 PF11825 Protein of unknown function (DUF3345), 0.0005 PF02166 Androgen receptor 0.0002 PF00061 Lipocalin / cytosolic fatty-acid binding protein family SUB359 C(~C)(:N) 0.0367 PF00227 Proteasome subunit 0.0336 PF03073 TspO/MBR family 0.0288 PF00069 Protein kinase domain 0.0265 PF00186 Dihydrofolate reductase 0.0261 PF01048 Phosphorylase superfamily 0.0189 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0158 PF00478 IMP dehydrogenase / GMP reductase domain 0.0124 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0110 PF00571 CBS domain 0.0090 PF00962 Adenosine/AMP deaminase 0.0086 PF03953 Tubulin C-terminal domain 0.0086 PF00091 Tubulin/FtsZ family, GTPase domain 0.0074 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0074 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0067 PF01590 GAF domain 0.0063 PF01126 Heme oxygenase 0.0054 PF00156 Phosphoribosyl transferase domain 0.0050 PF08240 Alcohol dehydrogenase GroES-like domain 0.0044 PF00107 Zinc-binding dehydrogenase 0.0043 PF00017 SH2 domain 0.0037 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0036 PF00858 Amiloride-sensitive sodium channel 0.0034 PF00018 SH3 domain 0.0031 PF00042 Globin 0.0029 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0029 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0026 PF00106 short chain dehydrogenase 0.0023 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0016 PF02267 ADP-ribosyl cyclase 0.0016 PF08919 F-actin binding 0.0015 PF00343 Carbohydrate phosphorylase 0.0014 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0014 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0014 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0011 PF00171 Aldehyde dehydrogenase family 0.0011 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0010 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0010 PF01467 Cytidylyltransferase 0.0010 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0008 PF00501 AMP-binding enzyme 0.0008 PF01122 Eukaryotic cobalamin-binding protein 0.0007 PF01119 DNA mismatch repair protein, C-terminal domain 0.0007 PF03104 DNA polymerase family B, exonuclease domain 0.0007 PF00821 Phosphoenolpyruvate carboxykinase 0.0007 PF01652 Eukaryotic initiation factor 4E 0.0007 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0007 PF12473 Kinesin protein 0.0007 PF08996 DNA Polymerase alpha zinc finger 0.0007 PF08676 MutL C terminal dimerisation domain 0.0007 PF12423 Kinesin protein 1B 0.0007 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0007 PF00970 Oxidoreductase FAD-binding domain 0.0007 PF02036 SCP-2 sterol transfer family 0.0007 PF00498 FHA domain 0.0007 PF00136 DNA polymerase family B 0.0007 PF10397 Adenylosuccinate lyase C-terminus 0.0007 PF01575 MaoC like domain 0.0006 PF02233 NAD(P), transhydrogenase beta subunit 0.0006 PF01808 AICARFT/IMPCHase bienzyme 0.0006 PF00931 NB-ARC domain 0.0006 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0006 PF00225 Kinesin motor domain 0.0006 PF00400 WD domain, G-beta repeat 0.0006 PF00005 ABC transporter 0.0006 PF02223 Thymidylate kinase 0.0006 PF01230 HIT domain 0.0006 PF07966 A1 Propeptide 0.0006 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0005 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0005 PF00690 Cation transporter/ATPase, N-terminus 0.0005 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0005 PF02525 Flavodoxin-like fold 0.0005 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0005 PF01064 Activin types I and II receptor domain 0.0005 PF08515 Transforming growth factor beta type I GS-motif 0.0005 PF00378 Enoyl-CoA hydratase/isomerase family 0.0005 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0005 PF00676 Dehydrogenase E1 component 0.0005 PF00689 Cation transporting ATPase, C-terminus 0.0005 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0005 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0005 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF00702 haloacid dehalogenase-like hydrolase 0.0005 PF00071 Ras family 0.0004 PF00390 Malic enzyme, N-terminal domain 0.0004 PF00958 GMP synthase C terminal domain 0.0004 PF01642 Methylmalonyl-CoA mutase 0.0004 PF03308 ArgK protein 0.0004 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0004 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0004 PF00248 Aldo/keto reductase family 0.0004 PF03949 Malic enzyme, NAD binding domain 0.0004 PF02867 Ribonucleotide reductase, barrel domain 0.0004 PF01923 Cobalamin adenosyltransferase 0.0004 PF03477 ATP cone domain 0.0004 PF03770 Inositol polyphosphate kinase 0.0004 PF00310 Glutamine amidotransferases class-II 0.0004 PF00317 Ribonucleotide reductase, all-alpha domain 0.0003 PF02310 B12 binding domain 0.0003 PF00334 Nucleoside diphosphate kinase 0.0003 PF00757 Furin-like cysteine rich region 0.0003 PF01030 Receptor L domain 0.0003 PF04679 ATP dependent DNA ligase C terminal region 0.0003 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0003 PF00122 E1-E2 ATPase 0.0003 PF11555 EGFR receptor inhibitor Mig-6 0.0003 PF00025 ADP-ribosylation factor family 0.0003 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0003 PF01404 Ephrin receptor ligand binding domain 0.0003 PF05347 Complex 1 protein (LYR family), 0.0003 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0003 PF09027 GTPase binding 0.0003 PF00536 SAM domain (Sterile alpha motif), 0.0003 PF01068 ATP dependent DNA ligase domain 0.0003 PF03024 Folate receptor family 0.0002 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0002 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0002 PF00794 PI3-kinase family, ras-binding domain 0.0002 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF00206 Lyase 0.0002 PF00533 BRCA1 C Terminus (BRCT), domain 0.0002 PF01916 Deoxyhypusine synthase 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0002 PF03530 Calcium-activated SK potassium channel 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF02888 Calmodulin binding domain 0.0002 PF02779 Transketolase, pyrimidine binding domain 0.0002 PF05406 WGR domain 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF08063 PADR1 (NUC008), domain 0.0002 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0001 PF00615 Regulator of G protein signaling domain 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF00629 MAM domain 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF00899 ThiF family 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF00026 Eukaryotic aspartyl protease 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF00439 Bromodomain 0.0001 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0001 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF00288 GHMP kinases N terminal domain 0.0001 PF00287 Sodium / potassium ATPase beta chain 0.0001 PF01434 Peptidase family M41 0.0001 PF00004 ATPase family associated with various cellular activities (AAA), 0.0001 PF00002 7 transmembrane receptor (Secretin family), 0.0001 PF01687 Riboflavin kinase 0.0001 PF01747 ATP-sulfurylase 0.0001 PF08544 GHMP kinases C terminal 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0001 PF00316 Fructose-1-6-bisphosphatase 0.0001 PF02772 S-adenosylmethionine synthetase, central domain 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF01835 MG2 domain 0.0001 PF00300 Phosphoglycerate mutase family 0.0001 PF10276 Zinc-finger domain 0.0001 PF10531 SLBB domain 0.0001 PF12062 heparan sulfate-N-deacetylase 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0001 PF02037 SAP domain 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF00291 Pyridoxal-phosphate dependent enzyme 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF01583 Adenylylsulphate kinase 0.0001 PF01582 TIR domain 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF00856 SET domain 0.0001 PF00183 Hsp90 protein 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF00012 Hsp70 protein 0.0001 PF02817 e3 binding domain 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF01591 6-phosphofructo-2-kinase 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF08040 MNLL subunit 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF02196 Raf-like Ras-binding domain 0.0001 PF10509 Galactokinase galactose-binding signature 0.0001 PF02793 Hormone receptor domain 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF02493 MORN repeat 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF06212 GRIM-19 protein 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF00221 Phenylalanine and histidine ammonia-lyase 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF02173 pKID domain SUB22 >= 8 O 0.0365 PF08702 Fibrinogen alpha/beta chain family 0.0365 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0228 PF00273 Serum albumin family 0.0208 PF09396 Thrombin light chain 0.0208 PF12160 Fibrinogen alpha C domain 0.0158 PF00167 Fibroblast growth factor 0.0140 PF01459 Eukaryotic porin 0.0123 PF00079 Serpin (serine protease inhibitor), 0.0122 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0104 PF00051 Kringle domain 0.0101 PF00089 Trypsin 0.0062 PF02146 Sir2 family 0.0062 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0051 PF00024 PAN domain 0.0050 PF00405 Transferrin 0.0032 PF00854 POT family 0.0027 PF02806 Alpha amylase, C-terminal all-beta domain 0.0026 PF00689 Cation transporting ATPase, C-terminus 0.0026 PF00690 Cation transporter/ATPase, N-terminus 0.0025 PF00059 Lectin C-type domain 0.0023 PF00122 E1-E2 ATPase 0.0022 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0021 PF00128 Alpha amylase, catalytic domain 0.0018 PF00702 haloacid dehalogenase-like hydrolase 0.0016 PF02793 Hormone receptor domain 0.0016 PF00002 7 transmembrane receptor (Secretin family), 0.0016 PF00084 Sushi domain (SCR repeat), 0.0015 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0015 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0015 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0015 PF10606 Homer-binding domain of metabotropic glutamate receptor 0.0015 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0014 PF00088 Trefoil (P-type), domain 0.0014 PF01055 Glycosyl hydrolases family 31 0.0013 PF04679 ATP dependent DNA ligase C terminal region 0.0013 PF01068 ATP dependent DNA ligase domain 0.0013 PF09193 Cholecystokinin A receptor, N-terminal 0.0011 PF00578 AhpC/TSA family 0.0011 PF00188 Cysteine-rich secretory protein family 0.0011 PF07562 Nine Cysteines Domain of family 3 GPCR 0.0011 PF10417 C-terminal domain of 1-Cys peroxiredoxin 0.0011 PF01370 NAD dependent epimerase/dehydratase family 0.0010 PF01731 Arylesterase 0.0010 PF03414 Glycosyltransferase family 6 0.0010 PF01323 DSBA-like thioredoxin domain 0.0009 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0009 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0009 PF08771 Rapamycin binding domain 0.0009 PF02260 FATC domain 0.0009 PF02259 FAT domain 0.0008 PF02460 Patched family 0.0008 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0008 PF03489 Saposin-like type B, region 2 0.0008 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0008 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0008 PF02180 Bcl-2 homology region 4 0.0007 PF00439 Bromodomain 0.0007 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0007 PF07678 A-macroglobulin complement component 0.0007 PF01835 MG2 domain 0.0007 PF07677 A-macroglobulin receptor 0.0007 PF06617 M-phase inducer phosphatase 0.0007 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0007 PF03062 MBOAT family 0.0007 PF00581 Rhodanese-like domain 0.0006 PF03073 TspO/MBR family 0.0006 PF01652 Eukaryotic initiation factor 4E 0.0006 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0006 PF03770 Inositol polyphosphate kinase 0.0005 PF00169 PH domain 0.0005 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0005 PF03953 Tubulin C-terminal domain 0.0005 PF00091 Tubulin/FtsZ family, GTPase domain 0.0005 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF02233 NAD(P), transhydrogenase beta subunit 0.0004 PF08983 Domain of unknown function (DUF1856), 0.0004 PF00248 Aldo/keto reductase family 0.0004 PF02267 ADP-ribosyl cyclase 0.0003 PF00106 short chain dehydrogenase 0.0003 PF00108 Thiolase, N-terminal domain 0.0003 PF00378 Enoyl-CoA hydratase/isomerase family 0.0003 PF05193 Peptidase M16 inactive domain 0.0003 PF00431 CUB domain 0.0003 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0003 PF00675 Insulinase (Peptidase family M16), 0.0003 PF02803 Thiolase, C-terminal domain 0.0003 PF00171 Aldehyde dehydrogenase family 0.0003 PF00151 Lipase 0.0002 PF01122 Eukaryotic cobalamin-binding protein 0.0002 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF00406 Adenylate kinase 0.0002 PF00779 BTK motif 0.0002 PF03360 Glycosyltransferase family 43 0.0002 PF07645 Calcium-binding EGF domain 0.0002 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0002 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0001 PF02223 Thymidylate kinase 0.0001 PF01268 Formate--tetrahydrofolate ligase 0.0001 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0001 PF01433 Peptidase family M1 0.0001 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0001 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0001 PF08246 Cathepsin propeptide inhibitor domain (I29), SUB536 O=C-C-C 0.0356 PF03098 Animal haem peroxidase 0.0284 PF00273 Serum albumin family 0.0279 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0279 PF08070 DTHCT (NUC029), region 0.0279 PF00204 DNA gyrase B 0.0217 PF00191 Annexin 0.0213 PF02155 Glucocorticoid receptor 0.0200 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0187 PF00105 Zinc finger, C4 type (two domains), 0.0185 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0171 PF01401 Angiotensin-converting enzyme 0.0156 PF00576 HIUase/Transthyretin family 0.0136 PF00102 Protein-tyrosine phosphatase 0.0119 PF00079 Serpin (serine protease inhibitor), 0.0117 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0095 PF01063 Aminotransferase class IV 0.0078 PF02159 Oestrogen receptor 0.0076 PF00091 Tubulin/FtsZ family, GTPase domain 0.0076 PF03953 Tubulin C-terminal domain 0.0072 PF00155 Aminotransferase class I and II 0.0067 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0050 PF01842 ACT domain 0.0046 PF00557 Metallopeptidase family M24 0.0044 PF00202 Aminotransferase class-III 0.0043 PF02806 Alpha amylase, C-terminal all-beta domain 0.0043 PF00303 Thymidylate synthase 0.0041 PF01735 Lysophospholipase catalytic domain 0.0037 PF02166 Androgen receptor 0.0024 PF00128 Alpha amylase, catalytic domain 0.0021 PF01268 Formate--tetrahydrofolate ligase 0.0020 PF00464 Serine hydroxymethyltransferase 0.0017 PF01126 Heme oxygenase 0.0017 PF05649 Peptidase family M13 0.0017 PF01431 Peptidase family M13 0.0016 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0016 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0013 PF03414 Glycosyltransferase family 6 0.0013 PF00248 Aldo/keto reductase family 0.0007 PF00291 Pyridoxal-phosphate dependent enzyme 0.0007 PF00175 Oxidoreductase NAD-binding domain 0.0006 PF00733 Asparagine synthase 0.0005 PF02898 Nitric oxide synthase, oxygenase domain 0.0004 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.0004 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.0004 PF00571 CBS domain 0.0004 PF00071 Ras family 0.0003 PF07706 Aminotransferase ubiquitination site 0.0003 PF00266 Aminotransferase class-V 0.0003 PF00667 FAD binding domain 0.0003 PF00258 Flavodoxin 0.0003 PF03171 2OG-Fe(II), oxygenase superfamily 0.0002 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0002 PF02798 Glutathione S-transferase, N-terminal domain 0.0001 PF00043 Glutathione S-transferase, C-terminal domain SUB691 O-C-C-C-C-C-O 0.0350 PF02806 Alpha amylase, C-terminal all-beta domain 0.0268 PF00128 Alpha amylase, catalytic domain 0.0261 PF03414 Glycosyltransferase family 6 0.0154 PF00079 Serpin (serine protease inhibitor), 0.0152 PF02155 Glucocorticoid receptor 0.0151 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0151 PF00204 DNA gyrase B 0.0151 PF08070 DTHCT (NUC029), region 0.0143 PF00191 Annexin 0.0125 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0106 PF00059 Lectin C-type domain 0.0101 PF00167 Fibroblast growth factor 0.0085 PF00084 Sushi domain (SCR repeat), 0.0076 PF07654 Immunoglobulin C1-set domain 0.0075 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0074 PF01735 Lysophospholipase catalytic domain 0.0067 PF01048 Phosphorylase superfamily 0.0060 PF00143 Interferon alpha/beta domain 0.0058 PF00091 Tubulin/FtsZ family, GTPase domain 0.0058 PF03953 Tubulin C-terminal domain 0.0051 PF02223 Thymidylate kinase 0.0047 PF03727 Hexokinase 0.0047 PF00349 Hexokinase 0.0046 PF08702 Fibrinogen alpha/beta chain family 0.0046 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0040 PF02267 ADP-ribosyl cyclase 0.0038 PF00303 Thymidylate synthase 0.0036 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0035 PF12160 Fibrinogen alpha C domain 0.0033 PF01370 NAD dependent epimerase/dehydratase family 0.0033 PF00106 short chain dehydrogenase 0.0033 PF00088 Trefoil (P-type), domain 0.0033 PF01055 Glycosyl hydrolases family 31 0.0030 PF00293 NUDIX domain 0.0030 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0030 PF07686 Immunoglobulin V-set domain 0.0029 PF02065 Melibiase 0.0028 PF00337 Galactoside-binding lectin 0.0028 PF00328 Histidine acid phosphatase 0.0025 PF00690 Cation transporter/ATPase, N-terminus 0.0025 PF07645 Calcium-binding EGF domain 0.0025 PF00689 Cation transporting ATPase, C-terminus 0.0023 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0022 PF01068 ATP dependent DNA ligase domain 0.0022 PF03770 Inositol polyphosphate kinase 0.0022 PF00089 Trypsin 0.0022 PF04679 ATP dependent DNA ligase C terminal region 0.0020 PF01532 Glycosyl hydrolase family 47 0.0020 PF00005 ABC transporter 0.0020 PF00122 E1-E2 ATPase 0.0019 PF01607 Chitin binding Peritrophin-A domain 0.0019 PF00704 Glycosyl hydrolases family 18 0.0019 PF00041 Fibronectin type III domain 0.0017 PF01467 Cytidylyltransferase 0.0017 PF00431 CUB domain 0.0016 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0014 PF00702 haloacid dehalogenase-like hydrolase 0.0014 PF00664 ABC transporter transmembrane region 0.0014 PF00171 Aldehyde dehydrogenase family 0.0013 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0013 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0012 PF00976 Corticotropin ACTH domain 0.0012 PF08384 Pro-opiomelanocortin, N-terminal region 0.0012 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.0012 PF08035 Opioids neuropeptide 0.0011 PF00024 PAN domain 0.0010 PF00031 Cystatin domain 0.0010 PF00403 Heavy-metal-associated domain 0.0010 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0010 PF04711 Apolipoprotein A-II (ApoA-II), 0.0010 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0009 PF00057 Low-density lipoprotein receptor domain class A 0.0009 PF07648 Kazal-type serine protease inhibitor domain 0.0009 PF00058 Low-density lipoprotein receptor repeat class B 0.0008 PF00884 Sulfatase 0.0008 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0008 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0008 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0007 PF02055 O-Glycosyl hydrolase family 30 0.0007 PF03171 2OG-Fe(II), oxygenase superfamily 0.0007 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0007 PF08240 Alcohol dehydrogenase GroES-like domain 0.0006 PF00093 von Willebrand factor type C domain 0.0006 PF00090 Thrombospondin type 1 domain 0.0006 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0006 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0006 PF01869 BadF/BadG/BcrA/BcrD ATPase family 0.0006 PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), 0.0006 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0006 PF00200 Disintegrin 0.0006 PF08516 ADAM cysteine-rich 0.0006 PF00236 Glycoprotein hormone 0.0006 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0006 PF00021 u-PAR/Ly-6 domain 0.0006 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0006 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0006 PF00703 domain 0.0006 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 0.0006 PF05735 Thrombospondin C-terminal region 0.0006 PF01562 Reprolysin family propeptide 0.0006 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0005 PF00183 Hsp90 protein 0.0004 PF00107 Zinc-binding dehydrogenase 0.0004 PF00248 Aldo/keto reductase family 0.0004 PF10420 Cytokine interleukin-12p40 C-terminus 0.0004 PF03781 Formylglycine-generating sulfatase enzyme 0.0004 PF00714 Interferon gamma 0.0003 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0003 PF00071 Ras family 0.0003 PF01687 Riboflavin kinase 0.0002 PF00571 CBS domain 0.0002 PF07884 Vitamin K epoxide reductase family 0.0002 PF01842 ACT domain 0.0002 PF01230 HIT domain 0.0002 PF01122 Eukaryotic cobalamin-binding protein 0.0002 PF08718 Glycolipid transfer protein (GLTP), 0.0001 PF03360 Glycosyltransferase family 43 SUB349 C(~C)(~H)(~P) 0.0327 PF00273 Serum albumin family 0.0253 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0238 PF08534 Redoxin 0.0124 PF00854 POT family 0.0069 PF09396 Thrombin light chain 0.0058 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0058 PF02180 Bcl-2 homology region 4 0.0044 PF02460 Patched family 0.0043 PF03062 MBOAT family 0.0043 PF01731 Arylesterase 0.0041 PF00151 Lipase 0.0034 PF00069 Protein kinase domain 0.0029 PF05649 Peptidase family M13 0.0029 PF01401 Angiotensin-converting enzyme 0.0029 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0029 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0029 PF00975 Thioesterase domain 0.0029 PF08659 KR domain 0.0029 PF01431 Peptidase family M13 0.0029 PF00698 Acyl transferase domain 0.0025 PF01477 PLAT/LH2 domain 0.0024 PF01433 Peptidase family M1 0.0021 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0021 PF00051 Kringle domain 0.0017 PF00576 HIUase/Transthyretin family 0.0016 PF00343 Carbohydrate phosphorylase 0.0016 PF00550 Phosphopantetheine attachment site 0.0014 PF00059 Lectin C-type domain 0.0014 PF02984 Cyclin, C-terminal domain 0.0014 PF12126 Protein of unknown function (DUF3583), 0.0014 PF00134 Cyclin, N-terminal domain 0.0014 PF07970 Endoplasmic reticulum vesicle transporter 0.0013 PF03957 Jun-like transcription factor 0.0013 PF03953 Tubulin C-terminal domain 0.0013 PF00091 Tubulin/FtsZ family, GTPase domain 0.0013 PF00489 Interleukin-6/G-CSF/MGF family 0.0011 PF07645 Calcium-binding EGF domain 0.0011 PF02423 Ornithine cyclodeaminase/mu-crystallin family 0.0010 PF00664 ABC transporter transmembrane region 0.0008 PF00170 bZIP transcription factor 0.0008 PF00005 ABC transporter 0.0007 PF00643 B-box zinc finger 0.0007 PF00107 Zinc-binding dehydrogenase 0.0005 PF00089 Trypsin 0.0004 PF00433 Protein kinase C terminal domain 0.0001 PF00462 Glutaredoxin 0.0001 PF03098 Animal haem peroxidase 0.0001 PF00169 PH domain 0.0001 PF00328 Histidine acid phosphatase SUB404 N(:C)(:C) 0.0326 PF00227 Proteasome subunit 0.0076 PF01048 Phosphorylase superfamily 0.0074 PF00069 Protein kinase domain 0.0067 PF00186 Dihydrofolate reductase 0.0054 PF00478 IMP dehydrogenase / GMP reductase domain 0.0053 PF03073 TspO/MBR family 0.0052 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0036 PF00571 CBS domain 0.0035 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0033 PF00962 Adenosine/AMP deaminase 0.0024 PF00156 Phosphoribosyl transferase domain 0.0022 PF01590 GAF domain 0.0021 PF08240 Alcohol dehydrogenase GroES-like domain 0.0020 PF00107 Zinc-binding dehydrogenase 0.0019 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0016 PF00106 short chain dehydrogenase 0.0015 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0015 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0015 PF00858 Amiloride-sensitive sodium channel 0.0015 PF00017 SH2 domain 0.0014 PF01126 Heme oxygenase 0.0013 PF00091 Tubulin/FtsZ family, GTPase domain 0.0013 PF00018 SH3 domain 0.0013 PF03953 Tubulin C-terminal domain 0.0012 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0012 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0012 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0011 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0011 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0010 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0010 PF00171 Aldehyde dehydrogenase family 0.0009 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0009 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0009 PF01467 Cytidylyltransferase 0.0008 PF08919 F-actin binding 0.0007 PF00501 AMP-binding enzyme 0.0007 PF01122 Eukaryotic cobalamin-binding protein 0.0006 PF12423 Kinesin protein 1B 0.0006 PF01652 Eukaryotic initiation factor 4E 0.0006 PF10397 Adenylosuccinate lyase C-terminus 0.0006 PF01230 HIT domain 0.0006 PF01575 MaoC like domain 0.0006 PF00498 FHA domain 0.0006 PF08676 MutL C terminal dimerisation domain 0.0006 PF00970 Oxidoreductase FAD-binding domain 0.0006 PF00821 Phosphoenolpyruvate carboxykinase 0.0006 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0006 PF02036 SCP-2 sterol transfer family 0.0006 PF00136 DNA polymerase family B 0.0006 PF01119 DNA mismatch repair protein, C-terminal domain 0.0006 PF12473 Kinesin protein 0.0006 PF00042 Globin 0.0006 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0006 PF08996 DNA Polymerase alpha zinc finger 0.0006 PF03104 DNA polymerase family B, exonuclease domain 0.0005 PF00400 WD domain, G-beta repeat 0.0005 PF02233 NAD(P), transhydrogenase beta subunit 0.0005 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0005 PF00931 NB-ARC domain 0.0005 PF00690 Cation transporter/ATPase, N-terminus 0.0005 PF01808 AICARFT/IMPCHase bienzyme 0.0005 PF00071 Ras family 0.0005 PF02223 Thymidylate kinase 0.0005 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0005 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0005 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0005 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0005 PF00225 Kinesin motor domain 0.0005 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0005 PF00689 Cation transporting ATPase, C-terminus 0.0005 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0005 PF07966 A1 Propeptide 0.0005 PF02267 ADP-ribosyl cyclase 0.0005 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0004 PF03949 Malic enzyme, NAD binding domain 0.0004 PF00390 Malic enzyme, N-terminal domain 0.0004 PF03308 ArgK protein 0.0004 PF00676 Dehydrogenase E1 component 0.0004 PF01923 Cobalamin adenosyltransferase 0.0004 PF00702 haloacid dehalogenase-like hydrolase 0.0004 PF00317 Ribonucleotide reductase, all-alpha domain 0.0004 PF01064 Activin types I and II receptor domain 0.0004 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0004 PF00958 GMP synthase C terminal domain 0.0004 PF00378 Enoyl-CoA hydratase/isomerase family 0.0004 PF02867 Ribonucleotide reductase, barrel domain 0.0004 PF02525 Flavodoxin-like fold 0.0004 PF03477 ATP cone domain 0.0004 PF01642 Methylmalonyl-CoA mutase 0.0004 PF08515 Transforming growth factor beta type I GS-motif 0.0004 PF03770 Inositol polyphosphate kinase 0.0004 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF00536 SAM domain (Sterile alpha motif), 0.0003 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF01404 Ephrin receptor ligand binding domain 0.0003 PF09027 GTPase binding 0.0003 PF00122 E1-E2 ATPase 0.0003 PF00343 Carbohydrate phosphorylase 0.0003 PF11555 EGFR receptor inhibitor Mig-6 0.0003 PF02310 B12 binding domain 0.0003 PF03024 Folate receptor family 0.0003 PF01068 ATP dependent DNA ligase domain 0.0003 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0003 PF00310 Glutamine amidotransferases class-II 0.0003 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0003 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0003 PF04679 ATP dependent DNA ligase C terminal region 0.0003 PF00025 ADP-ribosylation factor family 0.0003 PF00248 Aldo/keto reductase family 0.0003 PF05347 Complex 1 protein (LYR family), 0.0003 PF00334 Nucleoside diphosphate kinase 0.0003 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0002 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0002 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0002 PF01030 Receptor L domain 0.0002 PF00757 Furin-like cysteine rich region 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF00005 ABC transporter 0.0002 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0002 PF02888 Calmodulin binding domain 0.0002 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF05406 WGR domain 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF01916 Deoxyhypusine synthase 0.0002 PF03530 Calcium-activated SK potassium channel 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF00533 BRCA1 C Terminus (BRCT), domain 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF00206 Lyase 0.0002 PF02779 Transketolase, pyrimidine binding domain 0.0002 PF08063 PADR1 (NUC008), domain 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF02793 Hormone receptor domain 0.0001 PF02817 e3 binding domain 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF00792 Phosphoinositide 3-kinase C2 0.0001 PF00794 PI3-kinase family, ras-binding domain 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF02037 SAP domain 0.0001 PF02772 S-adenosylmethionine synthetase, central domain 0.0001 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0001 PF00221 Phenylalanine and histidine ammonia-lyase 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF06212 GRIM-19 protein 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF01835 MG2 domain 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF10509 Galactokinase galactose-binding signature 0.0001 PF01687 Riboflavin kinase 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF02173 pKID domain 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0001 PF00615 Regulator of G protein signaling domain 0.0001 PF10531 SLBB domain 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF10276 Zinc-finger domain 0.0001 PF01434 Peptidase family M41 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0001 PF00629 MAM domain 0.0001 PF00899 ThiF family 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF02493 MORN repeat 0.0001 PF00300 Phosphoglycerate mutase family 0.0001 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF01747 ATP-sulfurylase 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF00316 Fructose-1-6-bisphosphatase 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF08544 GHMP kinases C terminal 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF00002 7 transmembrane receptor (Secretin family), 0.0001 PF00004 ATPase family associated with various cellular activities (AAA), 0.0001 PF00026 Eukaryotic aspartyl protease 0.0001 PF00439 Bromodomain 0.0001 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0001 PF00012 Hsp70 protein 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF01583 Adenylylsulphate kinase 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF00856 SET domain 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF00287 Sodium / potassium ATPase beta chain 0.0001 PF00288 GHMP kinases N terminal domain 0.0001 PF01591 6-phosphofructo-2-kinase 0.0001 PF08040 MNLL subunit 0.0001 PF00183 Hsp90 protein 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF12062 heparan sulfate-N-deacetylase SUB388 C(:C)(:N) 0.0326 PF00227 Proteasome subunit 0.0045 PF01048 Phosphorylase superfamily 0.0038 PF00069 Protein kinase domain 0.0036 PF00478 IMP dehydrogenase / GMP reductase domain 0.0034 PF00186 Dihydrofolate reductase 0.0029 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0024 PF00571 CBS domain 0.0024 PF00962 Adenosine/AMP deaminase 0.0020 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0019 PF00156 Phosphoribosyl transferase domain 0.0016 PF08240 Alcohol dehydrogenase GroES-like domain 0.0016 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0016 PF00107 Zinc-binding dehydrogenase 0.0015 PF01590 GAF domain 0.0015 PF00106 short chain dehydrogenase 0.0013 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0013 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0012 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0012 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0012 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0012 PF00858 Amiloride-sensitive sodium channel 0.0010 PF00017 SH2 domain 0.0010 PF00171 Aldehyde dehydrogenase family 0.0010 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0009 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0009 PF00018 SH3 domain 0.0009 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0009 PF01467 Cytidylyltransferase 0.0007 PF08919 F-actin binding 0.0007 PF00501 AMP-binding enzyme 0.0007 PF01122 Eukaryotic cobalamin-binding protein 0.0006 PF00821 Phosphoenolpyruvate carboxykinase 0.0006 PF12423 Kinesin protein 1B 0.0006 PF01652 Eukaryotic initiation factor 4E 0.0006 PF12473 Kinesin protein 0.0006 PF08676 MutL C terminal dimerisation domain 0.0006 PF10397 Adenylosuccinate lyase C-terminus 0.0006 PF00498 FHA domain 0.0006 PF00136 DNA polymerase family B 0.0006 PF01575 MaoC like domain 0.0006 PF01230 HIT domain 0.0006 PF03104 DNA polymerase family B, exonuclease domain 0.0006 PF01119 DNA mismatch repair protein, C-terminal domain 0.0006 PF02036 SCP-2 sterol transfer family 0.0006 PF08996 DNA Polymerase alpha zinc finger 0.0006 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0006 PF01126 Heme oxygenase 0.0006 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0006 PF00970 Oxidoreductase FAD-binding domain 0.0005 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0005 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0005 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0005 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0005 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0005 PF00225 Kinesin motor domain 0.0005 PF02233 NAD(P), transhydrogenase beta subunit 0.0005 PF02223 Thymidylate kinase 0.0005 PF00400 WD domain, G-beta repeat 0.0005 PF00690 Cation transporter/ATPase, N-terminus 0.0005 PF01808 AICARFT/IMPCHase bienzyme 0.0005 PF00071 Ras family 0.0005 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0005 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0005 PF00931 NB-ARC domain 0.0005 PF00689 Cation transporting ATPase, C-terminus 0.0005 PF07966 A1 Propeptide 0.0004 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0004 PF01064 Activin types I and II receptor domain 0.0004 PF01923 Cobalamin adenosyltransferase 0.0004 PF02525 Flavodoxin-like fold 0.0004 PF03308 ArgK protein 0.0004 PF00390 Malic enzyme, N-terminal domain 0.0004 PF03770 Inositol polyphosphate kinase 0.0004 PF08515 Transforming growth factor beta type I GS-motif 0.0004 PF02867 Ribonucleotide reductase, barrel domain 0.0004 PF01642 Methylmalonyl-CoA mutase 0.0004 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0004 PF00317 Ribonucleotide reductase, all-alpha domain 0.0004 PF00958 GMP synthase C terminal domain 0.0004 PF00676 Dehydrogenase E1 component 0.0004 PF00702 haloacid dehalogenase-like hydrolase 0.0004 PF03949 Malic enzyme, NAD binding domain 0.0004 PF03477 ATP cone domain 0.0004 PF00378 Enoyl-CoA hydratase/isomerase family 0.0003 PF03024 Folate receptor family 0.0003 PF04679 ATP dependent DNA ligase C terminal region 0.0003 PF00025 ADP-ribosylation factor family 0.0003 PF05347 Complex 1 protein (LYR family), 0.0003 PF11555 EGFR receptor inhibitor Mig-6 0.0003 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF00248 Aldo/keto reductase family 0.0003 PF00536 SAM domain (Sterile alpha motif), 0.0003 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0003 PF01404 Ephrin receptor ligand binding domain 0.0003 PF00310 Glutamine amidotransferases class-II 0.0003 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0003 PF03073 TspO/MBR family 0.0003 PF00334 Nucleoside diphosphate kinase 0.0003 PF00122 E1-E2 ATPase 0.0003 PF09027 GTPase binding 0.0003 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0003 PF02267 ADP-ribosyl cyclase 0.0003 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0003 PF01068 ATP dependent DNA ligase domain 0.0003 PF02310 B12 binding domain 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF00005 ABC transporter 0.0002 PF00206 Lyase 0.0002 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0002 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0002 PF05406 WGR domain 0.0002 PF08063 PADR1 (NUC008), domain 0.0002 PF00757 Furin-like cysteine rich region 0.0002 PF02888 Calmodulin binding domain 0.0002 PF01030 Receptor L domain 0.0002 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0002 PF01916 Deoxyhypusine synthase 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF00533 BRCA1 C Terminus (BRCT), domain 0.0002 PF00042 Globin 0.0002 PF02779 Transketolase, pyrimidine binding domain 0.0002 PF03530 Calcium-activated SK potassium channel 0.0001 PF02772 S-adenosylmethionine synthetase, central domain 0.0001 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF02173 pKID domain 0.0001 PF01835 MG2 domain 0.0001 PF00012 Hsp70 protein 0.0001 PF02037 SAP domain 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0001 PF00026 Eukaryotic aspartyl protease 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF00221 Phenylalanine and histidine ammonia-lyase 0.0001 PF00316 Fructose-1-6-bisphosphatase 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF02793 Hormone receptor domain 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF01591 6-phosphofructo-2-kinase 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF08040 MNLL subunit 0.0001 PF06212 GRIM-19 protein 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF01687 Riboflavin kinase 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF01747 ATP-sulfurylase 0.0001 PF00183 Hsp90 protein 0.0001 PF02493 MORN repeat 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF00439 Bromodomain 0.0001 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF10509 Galactokinase galactose-binding signature 0.0001 PF01434 Peptidase family M41 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF10276 Zinc-finger domain 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF08544 GHMP kinases C terminal 0.0001 PF02817 e3 binding domain 0.0001 PF00300 Phosphoglycerate mutase family 0.0001 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF12062 heparan sulfate-N-deacetylase 0.0001 PF00899 ThiF family 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF00629 MAM domain 0.0001 PF00288 GHMP kinases N terminal domain 0.0001 PF00287 Sodium / potassium ATPase beta chain 0.0001 PF01583 Adenylylsulphate kinase 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF00856 SET domain 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF00004 ATPase family associated with various cellular activities (AAA), 0.0001 PF00002 7 transmembrane receptor (Secretin family), 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF00794 PI3-kinase family, ras-binding domain 0.0001 PF00792 Phosphoinositide 3-kinase C2 0.0001 PF10531 SLBB domain 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0001 PF00615 Regulator of G protein signaling domain SUB485 N-C:N:C 0.0310 PF00186 Dihydrofolate reductase 0.0165 PF00069 Protein kinase domain 0.0137 PF00478 IMP dehydrogenase / GMP reductase domain 0.0120 PF08240 Alcohol dehydrogenase GroES-like domain 0.0108 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0106 PF00107 Zinc-binding dehydrogenase 0.0106 PF01048 Phosphorylase superfamily 0.0098 PF00106 short chain dehydrogenase 0.0090 PF00571 CBS domain 0.0069 PF00962 Adenosine/AMP deaminase 0.0065 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0065 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0065 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0065 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0065 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0054 PF00171 Aldehyde dehydrogenase family 0.0044 PF00018 SH3 domain 0.0043 PF00248 Aldo/keto reductase family 0.0041 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0041 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0038 PF02223 Thymidylate kinase 0.0037 PF00156 Phosphoribosyl transferase domain 0.0032 PF00017 SH2 domain 0.0031 PF00501 AMP-binding enzyme 0.0028 PF08919 F-actin binding 0.0024 PF01467 Cytidylyltransferase 0.0019 PF00225 Kinesin motor domain 0.0018 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0018 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0018 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0016 PF01119 DNA mismatch repair protein, C-terminal domain 0.0016 PF00136 DNA polymerase family B 0.0016 PF03949 Malic enzyme, NAD binding domain 0.0016 PF08996 DNA Polymerase alpha zinc finger 0.0016 PF03104 DNA polymerase family B, exonuclease domain 0.0016 PF00970 Oxidoreductase FAD-binding domain 0.0016 PF01230 HIT domain 0.0016 PF12473 Kinesin protein 0.0016 PF01575 MaoC like domain 0.0016 PF00498 FHA domain 0.0016 PF12423 Kinesin protein 1B 0.0016 PF08676 MutL C terminal dimerisation domain 0.0016 PF02036 SCP-2 sterol transfer family 0.0016 PF00390 Malic enzyme, N-terminal domain 0.0014 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0014 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0014 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0014 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0013 PF02233 NAD(P), transhydrogenase beta subunit 0.0013 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0013 PF00400 WD domain, G-beta repeat 0.0013 PF00931 NB-ARC domain 0.0013 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0011 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0010 PF00317 Ribonucleotide reductase, all-alpha domain 0.0010 PF02867 Ribonucleotide reductase, barrel domain 0.0010 PF03477 ATP cone domain 0.0010 PF03770 Inositol polyphosphate kinase 0.0010 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0009 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0008 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0008 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0006 PF01122 Eukaryotic cobalamin-binding protein 0.0005 PF01030 Receptor L domain 0.0005 PF01268 Formate--tetrahydrofolate ligase 0.0005 PF00757 Furin-like cysteine rich region 0.0004 PF01642 Methylmalonyl-CoA mutase 0.0004 PF02310 B12 binding domain 0.0004 PF01923 Cobalamin adenosyltransferase 0.0004 PF00858 Amiloride-sensitive sodium channel 0.0004 PF03308 ArgK protein 0.0003 PF08515 Transforming growth factor beta type I GS-motif 0.0003 PF01064 Activin types I and II receptor domain 0.0003 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0003 PF00676 Dehydrogenase E1 component 0.0003 PF00378 Enoyl-CoA hydratase/isomerase family 0.0002 PF02607 B12 binding domain 0.0002 PF00431 CUB domain 0.0002 PF00258 Flavodoxin 0.0002 PF00809 Pterin binding enzyme 0.0002 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0002 PF00175 Oxidoreductase NAD-binding domain 0.0002 PF00667 FAD binding domain 0.0002 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0001 PF02574 Homocysteine S-methyltransferase 0.0001 PF00005 ABC transporter 0.0001 PF07645 Calcium-binding EGF domain 0.0001 PF01126 Heme oxygenase SUB543 O-C:C-[#1] 0.0282 PF02159 Oestrogen receptor 0.0149 PF00001 7 transmembrane receptor (rhodopsin family), 0.0122 PF00105 Zinc finger, C4 type (two domains), 0.0119 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0114 PF00204 DNA gyrase B 0.0114 PF08070 DTHCT (NUC029), region 0.0114 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0057 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0055 PF00576 HIUase/Transthyretin family 0.0055 PF12497 Estrogen receptor beta 0.0044 PF08035 Opioids neuropeptide 0.0044 PF08384 Pro-opiomelanocortin, N-terminal region 0.0044 PF00976 Corticotropin ACTH domain 0.0042 PF00102 Protein-tyrosine phosphatase 0.0042 PF00989 PAS fold 0.0041 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0034 PF00027 Cyclic nucleotide-binding domain 0.0033 PF00664 ABC transporter transmembrane region 0.0033 PF00005 ABC transporter 0.0028 PF11825 Protein of unknown function (DUF3345), 0.0023 PF00643 B-box zinc finger 0.0021 PF01596 O-methyltransferase 0.0016 PF00305 Lipoxygenase 0.0016 PF01477 PLAT/LH2 domain 0.0015 PF03062 MBOAT family 0.0015 PF02394 Interleukin-1 propeptide 0.0015 PF00340 Interleukin-1 / 18 0.0012 PF08983 Domain of unknown function (DUF1856), 0.0009 PF04622 ERG2 and Sigma1 receptor like protein 0.0008 PF00183 Hsp90 protein 0.0008 PF00656 Caspase domain 0.0008 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0008 PF00918 Gastrin/cholecystokinin family 0.0008 PF01160 Vertebrate endogenous opioids neuropeptide 0.0005 PF00135 Carboxylesterase 0.0005 PF01180 Dihydroorotate dehydrogenase 0.0005 PF01588 Putative tRNA binding domain 0.0005 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0005 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0005 PF00377 Prion/Doppel alpha-helical domain 0.0005 PF02180 Bcl-2 homology region 4 0.0005 PF08377 MAP2/Tau projection domain 0.0005 PF03765 CRAL/TRIO, N-terminus 0.0005 PF00650 CRAL/TRIO domain 0.0005 PF02460 Patched family 0.0005 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0004 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0004 PF00884 Sulfatase 0.0004 PF06327 Domain of Unknown Function (DUF1053), 0.0004 PF00357 Integrin alpha cytoplasmic region 0.0004 PF08441 Integrin alpha 0.0004 PF00625 Guanylate kinase 0.0003 PF09396 Thrombin light chain 0.0003 PF07885 Ion channel 0.0002 PF02025 Interleukin 5 0.0002 PF00002 7 transmembrane receptor (Secretin family), 0.0002 PF00641 Zn-finger in Ran binding protein and others 0.0002 PF08763 Voltage gated calcium channel IQ domain 0.0002 PF09193 Cholecystokinin A receptor, N-terminal 0.0002 PF00068 Phospholipase A2 0.0002 PF00094 von Willebrand factor type D domain 0.0002 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0002 PF00229 TNF(Tumour Necrosis Factor), family 0.0002 PF00170 bZIP transcription factor 0.0002 PF02793 Hormone receptor domain 0.0002 PF02201 SWIB/MDM2 domain 0.0002 PF00341 Platelet-derived growth factor (PDGF), 0.0002 PF08742 C8 domain 0.0001 PF01347 Lipoprotein amino terminal region 0.0001 PF01030 Receptor L domain 0.0001 PF02173 pKID domain 0.0001 PF00151 Lipase 0.0001 PF00620 RhoGAP domain 0.0001 PF00091 Tubulin/FtsZ family, GTPase domain 0.0001 PF00266 Aminotransferase class-V 0.0001 PF00757 Furin-like cysteine rich region 0.0001 PF01733 Nucleoside transporter 0.0001 PF03953 Tubulin C-terminal domain SUB524 N:C:C-C 0.0278 PF00227 Proteasome subunit 0.0039 PF01048 Phosphorylase superfamily 0.0032 PF00069 Protein kinase domain 0.0031 PF00478 IMP dehydrogenase / GMP reductase domain 0.0029 PF00186 Dihydrofolate reductase 0.0025 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0020 PF00962 Adenosine/AMP deaminase 0.0020 PF00571 CBS domain 0.0017 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0016 PF00156 Phosphoribosyl transferase domain 0.0014 PF00107 Zinc-binding dehydrogenase 0.0014 PF08240 Alcohol dehydrogenase GroES-like domain 0.0013 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0012 PF00106 short chain dehydrogenase 0.0012 PF01590 GAF domain 0.0011 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0011 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0010 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0010 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0010 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0010 PF00858 Amiloride-sensitive sodium channel 0.0009 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0009 PF00017 SH2 domain 0.0008 PF00018 SH3 domain 0.0008 PF01467 Cytidylyltransferase 0.0008 PF00171 Aldehyde dehydrogenase family 0.0007 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0007 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0006 PF01122 Eukaryotic cobalamin-binding protein 0.0006 PF00501 AMP-binding enzyme 0.0006 PF08919 F-actin binding 0.0005 PF00821 Phosphoenolpyruvate carboxykinase 0.0005 PF03104 DNA polymerase family B, exonuclease domain 0.0005 PF08996 DNA Polymerase alpha zinc finger 0.0005 PF02223 Thymidylate kinase 0.0005 PF12423 Kinesin protein 1B 0.0005 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0005 PF00498 FHA domain 0.0005 PF02036 SCP-2 sterol transfer family 0.0005 PF00970 Oxidoreductase FAD-binding domain 0.0005 PF08676 MutL C terminal dimerisation domain 0.0005 PF12473 Kinesin protein 0.0005 PF10397 Adenylosuccinate lyase C-terminus 0.0005 PF01126 Heme oxygenase 0.0005 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0005 PF00225 Kinesin motor domain 0.0005 PF01652 Eukaryotic initiation factor 4E 0.0005 PF01230 HIT domain 0.0005 PF01119 DNA mismatch repair protein, C-terminal domain 0.0005 PF01575 MaoC like domain 0.0005 PF00136 DNA polymerase family B 0.0004 PF00689 Cation transporting ATPase, C-terminus 0.0004 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0004 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0004 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0004 PF00676 Dehydrogenase E1 component 0.0004 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0004 PF00378 Enoyl-CoA hydratase/isomerase family 0.0004 PF00702 haloacid dehalogenase-like hydrolase 0.0004 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0004 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0004 PF00400 WD domain, G-beta repeat 0.0004 PF02233 NAD(P), transhydrogenase beta subunit 0.0004 PF08515 Transforming growth factor beta type I GS-motif 0.0004 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0004 PF07966 A1 Propeptide 0.0004 PF01064 Activin types I and II receptor domain 0.0004 PF00690 Cation transporter/ATPase, N-terminus 0.0004 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0004 PF01808 AICARFT/IMPCHase bienzyme 0.0004 PF00071 Ras family 0.0004 PF02525 Flavodoxin-like fold 0.0004 PF00931 NB-ARC domain 0.0004 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF03770 Inositol polyphosphate kinase 0.0003 PF03477 ATP cone domain 0.0003 PF00958 GMP synthase C terminal domain 0.0003 PF01923 Cobalamin adenosyltransferase 0.0003 PF01642 Methylmalonyl-CoA mutase 0.0003 PF00310 Glutamine amidotransferases class-II 0.0003 PF00317 Ribonucleotide reductase, all-alpha domain 0.0003 PF00122 E1-E2 ATPase 0.0003 PF03073 TspO/MBR family 0.0003 PF02867 Ribonucleotide reductase, barrel domain 0.0003 PF00248 Aldo/keto reductase family 0.0003 PF03308 ArgK protein 0.0003 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0003 PF03949 Malic enzyme, NAD binding domain 0.0003 PF00390 Malic enzyme, N-terminal domain 0.0002 PF00334 Nucleoside diphosphate kinase 0.0002 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF00025 ADP-ribosylation factor family 0.0002 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0002 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0002 PF11555 EGFR receptor inhibitor Mig-6 0.0002 PF00757 Furin-like cysteine rich region 0.0002 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0002 PF02267 ADP-ribosyl cyclase 0.0002 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0002 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0002 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0002 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF01030 Receptor L domain 0.0002 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF05406 WGR domain 0.0002 PF01404 Ephrin receptor ligand binding domain 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF00533 BRCA1 C Terminus (BRCT), domain 0.0002 PF00536 SAM domain (Sterile alpha motif), 0.0002 PF03024 Folate receptor family 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF09027 GTPase binding 0.0002 PF05347 Complex 1 protein (LYR family), 0.0002 PF04679 ATP dependent DNA ligase C terminal region 0.0002 PF00042 Globin 0.0002 PF01068 ATP dependent DNA ligase domain 0.0002 PF00206 Lyase 0.0002 PF08063 PADR1 (NUC008), domain 0.0002 PF02779 Transketolase, pyrimidine binding domain 0.0002 PF02310 B12 binding domain 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF00792 Phosphoinositide 3-kinase C2 0.0001 PF00794 PI3-kinase family, ras-binding domain 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF06212 GRIM-19 protein 0.0001 PF02772 S-adenosylmethionine synthetase, central domain 0.0001 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF02037 SAP domain 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF00221 Phenylalanine and histidine ammonia-lyase 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF02173 pKID domain 0.0001 PF01835 MG2 domain 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF01747 ATP-sulfurylase 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF01687 Riboflavin kinase 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF02817 e3 binding domain 0.0001 PF02888 Calmodulin binding domain 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF01916 Deoxyhypusine synthase 0.0001 PF00629 MAM domain 0.0001 PF10509 Galactokinase galactose-binding signature 0.0001 PF00899 ThiF family 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF03530 Calcium-activated SK potassium channel 0.0001 PF00300 Phosphoglycerate mutase family 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF02493 MORN repeat 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF00316 Fructose-1-6-bisphosphatase 0.0001 PF01434 Peptidase family M41 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF00004 ATPase family associated with various cellular activities (AAA), 0.0001 PF00005 ABC transporter 0.0001 PF00012 Hsp70 protein 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF01591 6-phosphofructo-2-kinase 0.0001 PF00287 Sodium / potassium ATPase beta chain 0.0001 PF00288 GHMP kinases N terminal domain 0.0001 PF00026 Eukaryotic aspartyl protease 0.0001 PF10276 Zinc-finger domain 0.0001 PF12062 heparan sulfate-N-deacetylase 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF00183 Hsp90 protein 0.0001 PF01583 Adenylylsulphate kinase 0.0001 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0001 PF00439 Bromodomain 0.0001 PF00856 SET domain 0.0001 PF10531 SLBB domain 0.0001 PF08040 MNLL subunit 0.0001 PF08544 GHMP kinases C terminal SUB783 OC1CCC(O)CC1 0.0269 PF08070 DTHCT (NUC029), region 0.0269 PF00204 DNA gyrase B 0.0269 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0108 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0097 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0097 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0062 PF01735 Lysophospholipase catalytic domain 0.0051 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0049 PF00989 PAS fold 0.0049 PF00576 HIUase/Transthyretin family 0.0044 PF00191 Annexin 0.0040 PF00102 Protein-tyrosine phosphatase 0.0040 PF00690 Cation transporter/ATPase, N-terminus 0.0040 PF00689 Cation transporting ATPase, C-terminus 0.0039 PF00194 Eukaryotic-type carbonic anhydrase 0.0039 PF02155 Glucocorticoid receptor 0.0039 PF00027 Cyclic nucleotide-binding domain 0.0038 PF03073 TspO/MBR family 0.0036 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0035 PF00122 E1-E2 ATPase 0.0034 PF02166 Androgen receptor 0.0033 PF00520 Ion transport protein 0.0033 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0030 PF00702 haloacid dehalogenase-like hydrolase 0.0030 PF03477 ATP cone domain 0.0030 PF00317 Ribonucleotide reductase, all-alpha domain 0.0030 PF02867 Ribonucleotide reductase, barrel domain 0.0030 PF00303 Thymidylate synthase 0.0029 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0029 PF00079 Serpin (serine protease inhibitor), 0.0025 PF00146 NADH dehydrogenase 0.0024 PF01180 Dihydroorotate dehydrogenase 0.0023 PF00168 C2 domain 0.0023 PF02214 K+ channel tetramerisation domain 0.0021 PF01030 Receptor L domain 0.0021 PF00757 Furin-like cysteine rich region 0.0019 PF00136 DNA polymerase family B 0.0019 PF03104 DNA polymerase family B, exonuclease domain 0.0019 PF08996 DNA Polymerase alpha zinc finger 0.0018 PF03098 Animal haem peroxidase 0.0017 PF00493 MCM2/3/5 family 0.0017 PF00248 Aldo/keto reductase family 0.0017 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0014 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 0.0014 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0012 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0012 PF05406 WGR domain 0.0012 PF08063 PADR1 (NUC008), domain 0.0012 PF02460 Patched family 0.0012 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0012 PF00533 BRCA1 C Terminus (BRCT), domain 0.0012 PF00069 Protein kinase domain 0.0012 PF00028 Cadherin domain 0.0011 PF03062 MBOAT family 0.0010 PF06448 Domain of Unknown Function (DUF1081), 0.0010 PF00654 Voltage gated chloride channel 0.0010 PF12491 Apolipoprotein B100 C terminal 0.0009 PF02196 Raf-like Ras-binding domain 0.0008 PF00489 Interleukin-6/G-CSF/MGF family 0.0008 PF00229 TNF(Tumour Necrosis Factor), family 0.0008 PF01731 Arylesterase 0.0006 PF02180 Bcl-2 homology region 4 0.0006 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0006 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0005 PF01347 Lipoprotein amino terminal region 0.0004 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0004 PF00554 Rel homology domain (RHD), 0.0003 PF00042 Globin 0.0003 PF00406 Adenylate kinase 0.0003 PF00058 Low-density lipoprotein receptor repeat class B 0.0002 PF01061 ABC-2 type transporter 0.0002 PF09396 Thrombin light chain 0.0002 PF08403 Amino acid permease N-terminal 0.0002 PF00432 Prenyltransferase and squalene oxidase repeat 0.0002 PF02864 STAT protein, DNA binding domain 0.0002 PF02865 STAT protein, protein interaction domain 0.0002 PF01391 Collagen triple helix repeat (20 copies), 0.0002 PF00821 Phosphoenolpyruvate carboxykinase 0.0002 PF01017 STAT protein, all-alpha domain 0.0002 PF01596 O-methyltransferase 0.0001 PF00656 Caspase domain 0.0001 PF00071 Ras family 0.0001 PF01433 Peptidase family M1 0.0001 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region SUB18 >= 8 N 0.0265 PF01122 Eukaryotic cobalamin-binding protein 0.0196 PF02310 B12 binding domain 0.0186 PF01642 Methylmalonyl-CoA mutase 0.0186 PF03308 ArgK protein 0.0186 PF01923 Cobalamin adenosyltransferase 0.0088 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0088 PF00809 Pterin binding enzyme 0.0088 PF02607 B12 binding domain 0.0086 PF00431 CUB domain 0.0081 PF00258 Flavodoxin 0.0081 PF00667 FAD binding domain 0.0080 PF00175 Oxidoreductase NAD-binding domain 0.0057 PF07645 Calcium-binding EGF domain 0.0045 PF02574 Homocysteine S-methyltransferase 0.0025 PF02223 Thymidylate kinase 0.0023 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0021 PF08240 Alcohol dehydrogenase GroES-like domain 0.0020 PF00106 short chain dehydrogenase 0.0018 PF00478 IMP dehydrogenase / GMP reductase domain 0.0018 PF00107 Zinc-binding dehydrogenase 0.0017 PF01126 Heme oxygenase 0.0016 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0015 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0015 PF00171 Aldehyde dehydrogenase family 0.0015 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0015 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0015 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0015 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0014 PF00571 CBS domain 0.0014 PF00248 Aldo/keto reductase family 0.0014 PF02267 ADP-ribosyl cyclase 0.0013 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0013 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0011 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0010 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0010 PF01467 Cytidylyltransferase 0.0010 PF00970 Oxidoreductase FAD-binding domain 0.0009 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0009 PF01652 Eukaryotic initiation factor 4E 0.0009 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0009 PF02233 NAD(P), transhydrogenase beta subunit 0.0009 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0008 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0008 PF03770 Inositol polyphosphate kinase 0.0008 PF02036 SCP-2 sterol transfer family 0.0008 PF01575 MaoC like domain 0.0008 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0007 PF00057 Low-density lipoprotein receptor domain class A 0.0007 PF00058 Low-density lipoprotein receptor repeat class B 0.0007 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0007 PF03949 Malic enzyme, NAD binding domain 0.0007 PF01687 Riboflavin kinase 0.0007 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0007 PF01268 Formate--tetrahydrofolate ligase 0.0007 PF01370 NAD dependent epimerase/dehydratase family 0.0007 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0007 PF00390 Malic enzyme, N-terminal domain 0.0006 PF02525 Flavodoxin-like fold 0.0006 PF00676 Dehydrogenase E1 component 0.0006 PF00348 Polyprenyl synthetase 0.0006 PF00017 SH2 domain 0.0006 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0006 PF00069 Protein kinase domain 0.0006 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0006 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0006 PF00186 Dihydrofolate reductase 0.0005 PF00018 SH3 domain 0.0005 PF01230 HIT domain 0.0004 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0004 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0004 PF01437 Plexin repeat 0.0004 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0004 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0004 PF02779 Transketolase, pyrimidine binding domain 0.0004 PF05347 Complex 1 protein (LYR family), 0.0004 PF01833 IPT/TIG domain 0.0004 PF01403 Sema domain 0.0004 PF00378 Enoyl-CoA hydratase/isomerase family 0.0003 PF00501 AMP-binding enzyme 0.0003 PF08676 MutL C terminal dimerisation domain 0.0003 PF12423 Kinesin protein 1B 0.0003 PF01119 DNA mismatch repair protein, C-terminal domain 0.0003 PF12473 Kinesin protein 0.0003 PF00498 FHA domain 0.0002 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0002 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0002 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0002 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0002 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0002 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0002 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0002 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0002 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0002 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0002 PF10276 Zinc-finger domain 0.0002 PF08040 MNLL subunit 0.0002 PF04116 Fatty acid hydroxylase superfamily 0.0002 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0002 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0002 PF09326 Domain of unknown function (DUF1982), 0.0002 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0002 PF00400 WD domain, G-beta repeat 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF04716 ETC complex I subunit conserved region 0.0002 PF09166 Biliverdin reductase, catalytic 0.0002 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0002 PF02817 e3 binding domain 0.0002 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0002 PF00931 NB-ARC domain 0.0002 PF04800 ETC complex I subunit conserved region 0.0002 PF02466 Tim17/Tim22/Tim23 family 0.0002 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0002 PF01808 AICARFT/IMPCHase bienzyme 0.0002 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0002 PF10531 SLBB domain 0.0002 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0002 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0002 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0002 PF01712 Deoxynucleoside kinase 0.0002 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0002 PF06212 GRIM-19 protein 0.0002 PF00794 PI3-kinase family, ras-binding domain 0.0002 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0002 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0002 PF00384 Molybdopterin oxidoreductase 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0002 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0002 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0002 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0002 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0002 PF00225 Kinesin motor domain 0.0002 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0002 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0002 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF01064 Activin types I and II receptor domain 0.0001 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0001 PF08515 Transforming growth factor beta type I GS-motif 0.0001 PF00962 Adenosine/AMP deaminase 0.0001 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0001 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0001 PF00042 Globin 0.0001 PF02173 pKID domain 0.0001 PF00406 Adenylate kinase 0.0001 PF00170 bZIP transcription factor 0.0001 PF02780 Transketolase, C-terminal domain 0.0001 PF03435 Saccharopine dehydrogenase SUB867 OC1C(O)CCC1 0.0259 PF00191 Annexin 0.0225 PF02155 Glucocorticoid receptor 0.0124 PF01735 Lysophospholipase catalytic domain 0.0120 PF00079 Serpin (serine protease inhibitor), 0.0076 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0074 PF00105 Zinc finger, C4 type (two domains), 0.0070 PF00204 DNA gyrase B 0.0070 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0070 PF08070 DTHCT (NUC029), region 0.0051 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0047 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0046 PF00168 C2 domain 0.0038 PF00091 Tubulin/FtsZ family, GTPase domain 0.0038 PF03953 Tubulin C-terminal domain 0.0037 PF00102 Protein-tyrosine phosphatase 0.0029 PF00557 Metallopeptidase family M24 0.0026 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0026 PF02180 Bcl-2 homology region 4 0.0023 PF00554 Rel homology domain (RHD), 0.0020 PF00183 Hsp90 protein 0.0020 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0020 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0019 PF00229 TNF(Tumour Necrosis Factor), family 0.0016 PF08384 Pro-opiomelanocortin, N-terminal region 0.0016 PF12497 Estrogen receptor beta 0.0016 PF00976 Corticotropin ACTH domain 0.0016 PF08035 Opioids neuropeptide 0.0015 PF02173 pKID domain 0.0015 PF03062 MBOAT family 0.0013 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0013 PF01477 PLAT/LH2 domain 0.0012 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0012 PF07690 Major Facilitator Superfamily 0.0011 PF02159 Oestrogen receptor 0.0010 PF00005 ABC transporter 0.0010 PF00170 bZIP transcription factor 0.0009 PF02260 FATC domain 0.0009 PF00151 Lipase 0.0009 PF08771 Rapamycin binding domain 0.0009 PF00656 Caspase domain 0.0009 PF01347 Lipoprotein amino terminal region 0.0009 PF02259 FAT domain 0.0009 PF00664 ABC transporter transmembrane region 0.0008 PF03171 2OG-Fe(II), oxygenase superfamily 0.0008 PF00341 Platelet-derived growth factor (PDGF), 0.0008 PF00531 Death domain 0.0007 PF07648 Kazal-type serine protease inhibitor domain 0.0007 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0006 PF00305 Lipoxygenase 0.0006 PF02525 Flavodoxin-like fold 0.0006 PF08742 C8 domain 0.0006 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0006 PF02025 Interleukin 5 0.0006 PF00176 SNF2 family N-terminal domain 0.0006 PF00271 Helicase conserved C-terminal domain 0.0006 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0006 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0006 PF00094 von Willebrand factor type D domain 0.0005 PF00975 Thioesterase domain 0.0005 PF00432 Prenyltransferase and squalene oxidase repeat 0.0005 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0005 PF00493 MCM2/3/5 family 0.0005 PF00698 Acyl transferase domain 0.0005 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0005 PF08659 KR domain 0.0004 PF02758 PAAD/DAPIN/Pyrin domain 0.0004 PF01596 O-methyltransferase 0.0003 PF00167 Fibroblast growth factor 0.0003 PF02166 Androgen receptor 0.0003 PF00224 Pyruvate kinase, barrel domain 0.0003 PF00377 Prion/Doppel alpha-helical domain 0.0003 PF02887 Pyruvate kinase, alpha/beta domain 0.0003 PF00040 Fibronectin type II domain 0.0003 PF01391 Collagen triple helix repeat (20 copies), 0.0003 PF03360 Glycosyltransferase family 43 0.0003 PF00489 Interleukin-6/G-CSF/MGF family 0.0003 PF00023 Ankyrin repeat 0.0002 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0002 PF03623 Focal adhesion targeting region 0.0002 PF02394 Interleukin-1 propeptide 0.0002 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0002 PF07884 Vitamin K epoxide reductase family 0.0002 PF01061 ABC-2 type transporter 0.0002 PF00274 Fructose-bisphosphate aldolase class-I 0.0002 PF02460 Patched family 0.0002 PF00354 Pentaxin family 0.0002 PF00071 Ras family 0.0002 PF00969 Class II histocompatibility antigen, beta domain 0.0002 PF12491 Apolipoprotein B100 C terminal 0.0002 PF02161 Progesterone receptor 0.0002 PF00340 Interleukin-1 / 18 0.0002 PF06448 Domain of Unknown Function (DUF1081), 0.0001 PF00643 B-box zinc finger 0.0001 PF00342 Phosphoglucose isomerase 0.0001 PF00622 SPRY domain 0.0001 PF00074 Pancreatic ribonuclease 0.0001 PF01023 S-100/ICaBP type calcium binding domain 0.0001 PF00067 Cytochrome P450 SUB606 O=C-C-O-C 0.0244 PF00191 Annexin 0.0212 PF02155 Glucocorticoid receptor 0.0117 PF01735 Lysophospholipase catalytic domain 0.0113 PF00079 Serpin (serine protease inhibitor), 0.0071 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0070 PF00105 Zinc finger, C4 type (two domains), 0.0066 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0066 PF08070 DTHCT (NUC029), region 0.0066 PF00204 DNA gyrase B 0.0048 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0044 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0043 PF00168 C2 domain 0.0036 PF03953 Tubulin C-terminal domain 0.0036 PF00091 Tubulin/FtsZ family, GTPase domain 0.0035 PF00102 Protein-tyrosine phosphatase 0.0027 PF00557 Metallopeptidase family M24 0.0025 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0025 PF02180 Bcl-2 homology region 4 0.0021 PF00554 Rel homology domain (RHD), 0.0019 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0019 PF00183 Hsp90 protein 0.0018 PF00229 TNF(Tumour Necrosis Factor), family 0.0018 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0015 PF08035 Opioids neuropeptide 0.0015 PF00976 Corticotropin ACTH domain 0.0015 PF08384 Pro-opiomelanocortin, N-terminal region 0.0015 PF12497 Estrogen receptor beta 0.0014 PF02173 pKID domain 0.0014 PF03062 MBOAT family 0.0012 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0012 PF01477 PLAT/LH2 domain 0.0012 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0011 PF07690 Major Facilitator Superfamily 0.0010 PF02159 Oestrogen receptor 0.0010 PF00170 bZIP transcription factor 0.0009 PF00005 ABC transporter 0.0009 PF00151 Lipase 0.0009 PF00656 Caspase domain 0.0009 PF00664 ABC transporter transmembrane region 0.0008 PF00341 Platelet-derived growth factor (PDGF), 0.0008 PF02259 FAT domain 0.0008 PF01347 Lipoprotein amino terminal region 0.0008 PF03171 2OG-Fe(II), oxygenase superfamily 0.0008 PF02260 FATC domain 0.0008 PF08771 Rapamycin binding domain 0.0007 PF07648 Kazal-type serine protease inhibitor domain 0.0007 PF00531 Death domain 0.0007 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0006 PF00305 Lipoxygenase 0.0006 PF00176 SNF2 family N-terminal domain 0.0006 PF02525 Flavodoxin-like fold 0.0006 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0006 PF00094 von Willebrand factor type D domain 0.0006 PF01826 Trypsin Inhibitor like cysteine rich domain 0.0006 PF02025 Interleukin 5 0.0006 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0006 PF08742 C8 domain 0.0005 PF00698 Acyl transferase domain 0.0005 PF00432 Prenyltransferase and squalene oxidase repeat 0.0005 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0005 PF08659 KR domain 0.0005 PF00493 MCM2/3/5 family 0.0005 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0005 PF00271 Helicase conserved C-terminal domain 0.0005 PF00975 Thioesterase domain 0.0004 PF01596 O-methyltransferase 0.0004 PF02758 PAAD/DAPIN/Pyrin domain 0.0003 PF01391 Collagen triple helix repeat (20 copies), 0.0003 PF03360 Glycosyltransferase family 43 0.0003 PF00489 Interleukin-6/G-CSF/MGF family 0.0003 PF00040 Fibronectin type II domain 0.0003 PF02887 Pyruvate kinase, alpha/beta domain 0.0003 PF00167 Fibroblast growth factor 0.0003 PF00377 Prion/Doppel alpha-helical domain 0.0003 PF00224 Pyruvate kinase, barrel domain 0.0003 PF02166 Androgen receptor 0.0003 PF00023 Ankyrin repeat 0.0002 PF02460 Patched family 0.0002 PF07884 Vitamin K epoxide reductase family 0.0002 PF06448 Domain of Unknown Function (DUF1081), 0.0002 PF00969 Class II histocompatibility antigen, beta domain 0.0002 PF00340 Interleukin-1 / 18 0.0002 PF02161 Progesterone receptor 0.0002 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 0.0002 PF00071 Ras family 0.0002 PF03623 Focal adhesion targeting region 0.0002 PF02394 Interleukin-1 propeptide 0.0002 PF12491 Apolipoprotein B100 C terminal 0.0002 PF00274 Fructose-bisphosphate aldolase class-I 0.0002 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.0002 PF01061 ABC-2 type transporter 0.0002 PF00354 Pentaxin family 0.0001 PF00622 SPRY domain 0.0001 PF00067 Cytochrome P450 0.0001 PF00074 Pancreatic ribonuclease 0.0001 PF00342 Phosphoglucose isomerase 0.0001 PF00643 B-box zinc finger 0.0001 PF01023 S-100/ICaBP type calcium binding domain SUB698 C-C-C-C-C-C(C)-C 0.0221 PF02159 Oestrogen receptor 0.0160 PF00105 Zinc finger, C4 type (two domains), 0.0159 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0139 PF00001 7 transmembrane receptor (rhodopsin family), 0.0136 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0136 PF08070 DTHCT (NUC029), region 0.0136 PF00204 DNA gyrase B 0.0112 PF00191 Annexin 0.0102 PF02155 Glucocorticoid receptor 0.0087 PF02161 Progesterone receptor 0.0062 PF02166 Androgen receptor 0.0057 PF01735 Lysophospholipase catalytic domain 0.0056 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0046 PF00079 Serpin (serine protease inhibitor), 0.0035 PF08384 Pro-opiomelanocortin, N-terminal region 0.0035 PF00976 Corticotropin ACTH domain 0.0035 PF08035 Opioids neuropeptide 0.0030 PF12497 Estrogen receptor beta 0.0027 PF00005 ABC transporter 0.0026 PF01401 Angiotensin-converting enzyme 0.0025 PF00664 ABC transporter transmembrane region 0.0023 PF00168 C2 domain 0.0023 PF09396 Thrombin light chain 0.0018 PF03953 Tubulin C-terminal domain 0.0018 PF00091 Tubulin/FtsZ family, GTPase domain 0.0017 PF00989 PAS fold 0.0017 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0015 PF00097 Zinc finger, C3HC4 type (RING finger), 0.0013 PF00027 Cyclic nucleotide-binding domain 0.0013 PF07884 Vitamin K epoxide reductase family 0.0013 PF00186 Dihydrofolate reductase 0.0008 PF00042 Globin 0.0006 PF00067 Cytochrome P450 0.0006 PF11825 Protein of unknown function (DUF3345), 0.0006 PF00305 Lipoxygenase 0.0006 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0006 PF00051 Kringle domain 0.0005 PF00643 B-box zinc finger 0.0005 PF01061 ABC-2 type transporter 0.0004 PF02394 Interleukin-1 propeptide 0.0004 PF00229 TNF(Tumour Necrosis Factor), family 0.0004 PF07648 Kazal-type serine protease inhibitor domain 0.0004 PF04622 ERG2 and Sigma1 receptor like protein 0.0004 PF00340 Interleukin-1 / 18 0.0003 PF00554 Rel homology domain (RHD), 0.0003 PF06327 Domain of Unknown Function (DUF1053), 0.0003 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0003 PF01477 PLAT/LH2 domain 0.0003 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0002 PF08441 Integrin alpha 0.0002 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.0002 PF00357 Integrin alpha cytoplasmic region 0.0002 PF03765 CRAL/TRIO, N-terminus 0.0002 PF07885 Ion channel 0.0002 PF00650 CRAL/TRIO domain 0.0001 PF08771 Rapamycin binding domain 0.0001 PF00212 Atrial natriuretic peptide 0.0001 PF02260 FATC domain 0.0001 PF03062 MBOAT family 0.0001 PF00341 Platelet-derived growth factor (PDGF), 0.0001 PF02259 FAT domain 0.0001 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase SUB686 O=C-C-C-C-N 0.0217 PF02798 Glutathione S-transferase, N-terminal domain 0.0212 PF00043 Glutathione S-transferase, C-terminal domain 0.0129 PF00255 Glutathione peroxidase 0.0104 PF05649 Peptidase family M13 0.0104 PF01431 Peptidase family M13 0.0090 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0073 PF01124 MAPEG family 0.0067 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0064 PF00091 Tubulin/FtsZ family, GTPase domain 0.0064 PF03953 Tubulin C-terminal domain 0.0062 PF01401 Angiotensin-converting enzyme 0.0059 PF09396 Thrombin light chain 0.0057 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0057 PF03199 Eukaryotic glutathione synthase 0.0044 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0043 PF01323 DSBA-like thioredoxin domain 0.0039 PF00656 Caspase domain 0.0038 PF08983 Domain of unknown function (DUF1856), 0.0036 PF00303 Thymidylate synthase 0.0034 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0032 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0031 PF00462 Glutaredoxin 0.0030 PF07722 Peptidase C26 0.0026 PF01406 tRNA synthetases class I (C), catalytic domain 0.0025 PF05995 Cysteine dioxygenase type I 0.0025 PF00756 Putative esterase 0.0025 PF01019 Gamma-glutamyltranspeptidase 0.0022 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0022 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0021 PF03074 Glutamate-cysteine ligase 0.0021 PF00619 Caspase recruitment domain 0.0014 PF00439 Bromodomain 0.0014 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0014 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0013 PF06617 M-phase inducer phosphatase 0.0013 PF00581 Rhodanese-like domain 0.0011 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0011 PF03002 Somatostatin/Cortistatin family 0.0011 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0010 PF00085 Thioredoxin 0.0009 PF08833 Axin beta-catenin binding domain 0.0009 PF00778 DIX domain 0.0009 PF00822 PMP-22/EMP/MP20/Claudin family 0.0009 PF00806 Pumilio-family RNA binding repeat 0.0008 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0008 PF00265 Thymidine kinase 0.0008 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0007 PF00931 NB-ARC domain 0.0007 PF00342 Phosphoglucose isomerase 0.0007 PF00400 WD domain, G-beta repeat 0.0005 PF00002 7 transmembrane receptor (Secretin family), 0.0005 PF02793 Hormone receptor domain 0.0004 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF00586 AIR synthase related protein, N-terminal domain 0.0002 PF10420 Cytokine interleukin-12p40 C-terminus 0.0002 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0002 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0002 PF02769 AIR synthase related protein, C-terminal domain 0.0001 PF01471 Putative peptidoglycan binding domain 0.0001 PF00045 Hemopexin 0.0001 PF02803 Thiolase, C-terminal domain 0.0001 PF00108 Thiolase, N-terminal domain SUB448 C(-H)(=N) 0.0213 PF00227 Proteasome subunit 0.0030 PF01048 Phosphorylase superfamily 0.0025 PF00069 Protein kinase domain 0.0024 PF00478 IMP dehydrogenase / GMP reductase domain 0.0022 PF00186 Dihydrofolate reductase 0.0019 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0016 PF00571 CBS domain 0.0015 PF00962 Adenosine/AMP deaminase 0.0013 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0012 PF00156 Phosphoribosyl transferase domain 0.0011 PF08240 Alcohol dehydrogenase GroES-like domain 0.0010 PF01590 GAF domain 0.0010 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0010 PF00107 Zinc-binding dehydrogenase 0.0009 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0009 PF00106 short chain dehydrogenase 0.0009 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0008 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0008 PF00858 Amiloride-sensitive sodium channel 0.0008 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0008 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0007 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0007 PF00017 SH2 domain 0.0006 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0006 PF00018 SH3 domain 0.0006 PF00171 Aldehyde dehydrogenase family 0.0006 PF01467 Cytidylyltransferase 0.0006 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0005 PF08919 F-actin binding 0.0005 PF01122 Eukaryotic cobalamin-binding protein 0.0005 PF00501 AMP-binding enzyme 0.0004 PF01575 MaoC like domain 0.0004 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0004 PF10397 Adenylosuccinate lyase C-terminus 0.0004 PF02036 SCP-2 sterol transfer family 0.0004 PF12473 Kinesin protein 0.0004 PF00821 Phosphoenolpyruvate carboxykinase 0.0004 PF01230 HIT domain 0.0004 PF00498 FHA domain 0.0004 PF12423 Kinesin protein 1B 0.0004 PF01119 DNA mismatch repair protein, C-terminal domain 0.0004 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0004 PF01652 Eukaryotic initiation factor 4E 0.0004 PF08676 MutL C terminal dimerisation domain 0.0004 PF00970 Oxidoreductase FAD-binding domain 0.0004 PF08996 DNA Polymerase alpha zinc finger 0.0004 PF03104 DNA polymerase family B, exonuclease domain 0.0004 PF02223 Thymidylate kinase 0.0004 PF01126 Heme oxygenase 0.0004 PF00136 DNA polymerase family B 0.0003 PF02233 NAD(P), transhydrogenase beta subunit 0.0003 PF01923 Cobalamin adenosyltransferase 0.0003 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0003 PF01642 Methylmalonyl-CoA mutase 0.0003 PF00071 Ras family 0.0003 PF01808 AICARFT/IMPCHase bienzyme 0.0003 PF00690 Cation transporter/ATPase, N-terminus 0.0003 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF00225 Kinesin motor domain 0.0003 PF00390 Malic enzyme, N-terminal domain 0.0003 PF00400 WD domain, G-beta repeat 0.0003 PF00317 Ribonucleotide reductase, all-alpha domain 0.0003 PF00689 Cation transporting ATPase, C-terminus 0.0003 PF02525 Flavodoxin-like fold 0.0003 PF03477 ATP cone domain 0.0003 PF02867 Ribonucleotide reductase, barrel domain 0.0003 PF00378 Enoyl-CoA hydratase/isomerase family 0.0003 PF07966 A1 Propeptide 0.0003 PF01064 Activin types I and II receptor domain 0.0003 PF00931 NB-ARC domain 0.0003 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0003 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0003 PF03308 ArgK protein 0.0003 PF08515 Transforming growth factor beta type I GS-motif 0.0003 PF00958 GMP synthase C terminal domain 0.0003 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0003 PF00702 haloacid dehalogenase-like hydrolase 0.0003 PF03949 Malic enzyme, NAD binding domain 0.0003 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0003 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0003 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0003 PF00676 Dehydrogenase E1 component 0.0003 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0002 PF03770 Inositol polyphosphate kinase 0.0002 PF04679 ATP dependent DNA ligase C terminal region 0.0002 PF00248 Aldo/keto reductase family 0.0002 PF02310 B12 binding domain 0.0002 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0002 PF00025 ADP-ribosylation factor family 0.0002 PF01404 Ephrin receptor ligand binding domain 0.0002 PF00334 Nucleoside diphosphate kinase 0.0002 PF03024 Folate receptor family 0.0002 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0002 PF00310 Glutamine amidotransferases class-II 0.0002 PF09027 GTPase binding 0.0002 PF03073 TspO/MBR family 0.0002 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0002 PF00536 SAM domain (Sterile alpha motif), 0.0002 PF05347 Complex 1 protein (LYR family), 0.0002 PF02267 ADP-ribosyl cyclase 0.0002 PF11555 EGFR receptor inhibitor Mig-6 0.0002 PF01068 ATP dependent DNA ligase domain 0.0002 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0002 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0002 PF00122 E1-E2 ATPase 0.0001 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0001 PF01591 6-phosphofructo-2-kinase 0.0001 PF01583 Adenylylsulphate kinase 0.0001 PF02888 Calmodulin binding domain 0.0001 PF12062 heparan sulfate-N-deacetylase 0.0001 PF07703 Alpha-2-macroglobulin family N-terminal region 0.0001 PF00899 ThiF family 0.0001 PF10531 SLBB domain 0.0001 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0001 PF08544 GHMP kinases C terminal 0.0001 PF01747 ATP-sulfurylase 0.0001 PF00856 SET domain 0.0001 PF01916 Deoxyhypusine synthase 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF07677 A-macroglobulin receptor 0.0001 PF10276 Zinc-finger domain 0.0001 PF07678 A-macroglobulin complement component 0.0001 PF05406 WGR domain 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF01434 Peptidase family M41 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0001 PF00300 Phosphoglycerate mutase family 0.0001 PF00004 ATPase family associated with various cellular activities (AAA), 0.0001 PF00005 ABC transporter 0.0001 PF02817 e3 binding domain 0.0001 PF01030 Receptor L domain 0.0001 PF00533 BRCA1 C Terminus (BRCT), domain 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF03530 Calcium-activated SK potassium channel 0.0001 PF02493 MORN repeat 0.0001 PF00757 Furin-like cysteine rich region 0.0001 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0001 PF00012 Hsp70 protein 0.0001 PF02779 Transketolase, pyrimidine binding domain 0.0001 PF00221 Phenylalanine and histidine ammonia-lyase 0.0001 PF10509 Galactokinase galactose-binding signature 0.0001 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0001 PF02772 S-adenosylmethionine synthetase, central domain 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF00316 Fructose-1-6-bisphosphatase 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF01835 MG2 domain 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF00439 Bromodomain 0.0001 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0001 PF00629 MAM domain 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF06212 GRIM-19 protein 0.0001 PF01712 Deoxynucleoside kinase 0.0001 PF00183 Hsp90 protein 0.0001 PF08040 MNLL subunit 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF00042 Globin 0.0001 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF00206 Lyase 0.0001 PF08063 PADR1 (NUC008), domain 0.0001 PF00794 PI3-kinase family, ras-binding domain 0.0001 PF00792 Phosphoinositide 3-kinase C2 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF00026 Eukaryotic aspartyl protease 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF01268 Formate--tetrahydrofolate ligase 0.0001 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0001 PF02037 SAP domain 0.0001 PF00288 GHMP kinases N terminal domain 0.0001 PF00287 Sodium / potassium ATPase beta chain 0.0001 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0001 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 SUB398 N(~C)(:C)(:C) 0.0176 PF01122 Eukaryotic cobalamin-binding protein 0.0131 PF02310 B12 binding domain 0.0124 PF03308 ArgK protein 0.0124 PF01923 Cobalamin adenosyltransferase 0.0124 PF01642 Methylmalonyl-CoA mutase 0.0059 PF00809 Pterin binding enzyme 0.0059 PF02607 B12 binding domain 0.0059 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0058 PF00431 CUB domain 0.0054 PF00667 FAD binding domain 0.0054 PF00258 Flavodoxin 0.0053 PF00175 Oxidoreductase NAD-binding domain 0.0038 PF07645 Calcium-binding EGF domain 0.0030 PF02574 Homocysteine S-methyltransferase 0.0017 PF02223 Thymidylate kinase 0.0015 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0014 PF08240 Alcohol dehydrogenase GroES-like domain 0.0013 PF00106 short chain dehydrogenase 0.0012 PF00107 Zinc-binding dehydrogenase 0.0012 PF00478 IMP dehydrogenase / GMP reductase domain 0.0011 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0011 PF01126 Heme oxygenase 0.0010 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0010 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0010 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0010 PF00171 Aldehyde dehydrogenase family 0.0010 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0010 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0009 PF00571 CBS domain 0.0009 PF00248 Aldo/keto reductase family 0.0009 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0009 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0009 PF02267 ADP-ribosyl cyclase 0.0007 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0007 PF00970 Oxidoreductase FAD-binding domain 0.0007 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0007 PF01467 Cytidylyltransferase 0.0006 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0006 PF01652 Eukaryotic initiation factor 4E 0.0006 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0006 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0006 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0006 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0006 PF02233 NAD(P), transhydrogenase beta subunit 0.0005 PF03770 Inositol polyphosphate kinase 0.0005 PF01370 NAD dependent epimerase/dehydratase family 0.0005 PF01575 MaoC like domain 0.0005 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0005 PF01268 Formate--tetrahydrofolate ligase 0.0005 PF02036 SCP-2 sterol transfer family 0.0005 PF01687 Riboflavin kinase 0.0005 PF00058 Low-density lipoprotein receptor repeat class B 0.0005 PF00057 Low-density lipoprotein receptor domain class A 0.0005 PF03949 Malic enzyme, NAD binding domain 0.0005 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0005 PF00390 Malic enzyme, N-terminal domain 0.0005 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0004 PF02525 Flavodoxin-like fold 0.0004 PF00186 Dihydrofolate reductase 0.0004 PF00348 Polyprenyl synthetase 0.0004 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0004 PF00069 Protein kinase domain 0.0004 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0004 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0004 PF00017 SH2 domain 0.0004 PF00676 Dehydrogenase E1 component 0.0003 PF00378 Enoyl-CoA hydratase/isomerase family 0.0003 PF00018 SH3 domain 0.0003 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0003 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0003 PF05347 Complex 1 protein (LYR family), 0.0003 PF01230 HIT domain 0.0002 PF08676 MutL C terminal dimerisation domain 0.0002 PF02779 Transketolase, pyrimidine binding domain 0.0002 PF00498 FHA domain 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF01437 Plexin repeat 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF00794 PI3-kinase family, ras-binding domain 0.0002 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF01119 DNA mismatch repair protein, C-terminal domain 0.0002 PF01833 IPT/TIG domain 0.0002 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0002 PF00501 AMP-binding enzyme 0.0002 PF12423 Kinesin protein 1B 0.0002 PF12473 Kinesin protein 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF01403 Sema domain 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF00400 WD domain, G-beta repeat 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF10531 SLBB domain 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF01712 Deoxynucleoside kinase 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF01808 AICARFT/IMPCHase bienzyme 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF10276 Zinc-finger domain 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF02817 e3 binding domain 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF02173 pKID domain 0.0001 PF06212 GRIM-19 protein 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF00931 NB-ARC domain 0.0001 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0001 PF08040 MNLL subunit 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF00962 Adenosine/AMP deaminase 0.0001 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0001 PF00225 Kinesin motor domain 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus SUB613 N-C-O-C-C 0.0173 PF01122 Eukaryotic cobalamin-binding protein 0.0128 PF02310 B12 binding domain 0.0122 PF03308 ArgK protein 0.0122 PF01642 Methylmalonyl-CoA mutase 0.0122 PF01923 Cobalamin adenosyltransferase 0.0058 PF00809 Pterin binding enzyme 0.0058 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0058 PF02607 B12 binding domain 0.0056 PF00431 CUB domain 0.0053 PF00667 FAD binding domain 0.0053 PF00258 Flavodoxin 0.0052 PF00175 Oxidoreductase NAD-binding domain 0.0037 PF07645 Calcium-binding EGF domain 0.0030 PF02574 Homocysteine S-methyltransferase 0.0016 PF02223 Thymidylate kinase 0.0015 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0014 PF08240 Alcohol dehydrogenase GroES-like domain 0.0013 PF00106 short chain dehydrogenase 0.0012 PF00478 IMP dehydrogenase / GMP reductase domain 0.0012 PF00107 Zinc-binding dehydrogenase 0.0011 PF01126 Heme oxygenase 0.0010 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0010 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0010 PF00171 Aldehyde dehydrogenase family 0.0010 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0010 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0010 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0010 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0009 PF02267 ADP-ribosyl cyclase 0.0009 PF00248 Aldo/keto reductase family 0.0009 PF00571 CBS domain 0.0008 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0008 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0007 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0007 PF00970 Oxidoreductase FAD-binding domain 0.0007 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0007 PF01467 Cytidylyltransferase 0.0006 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0006 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0006 PF02233 NAD(P), transhydrogenase beta subunit 0.0006 PF01652 Eukaryotic initiation factor 4E 0.0006 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0006 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0006 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0005 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0005 PF01687 Riboflavin kinase 0.0005 PF00390 Malic enzyme, N-terminal domain 0.0005 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0005 PF02036 SCP-2 sterol transfer family 0.0005 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0005 PF01575 MaoC like domain 0.0005 PF03949 Malic enzyme, NAD binding domain 0.0005 PF03770 Inositol polyphosphate kinase 0.0004 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0004 PF00017 SH2 domain 0.0004 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0004 PF01268 Formate--tetrahydrofolate ligase 0.0004 PF00057 Low-density lipoprotein receptor domain class A 0.0004 PF00058 Low-density lipoprotein receptor repeat class B 0.0004 PF00348 Polyprenyl synthetase 0.0004 PF00676 Dehydrogenase E1 component 0.0004 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0004 PF00186 Dihydrofolate reductase 0.0004 PF01370 NAD dependent epimerase/dehydratase family 0.0004 PF02525 Flavodoxin-like fold 0.0004 PF00069 Protein kinase domain 0.0003 PF00378 Enoyl-CoA hydratase/isomerase family 0.0003 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0003 PF05347 Complex 1 protein (LYR family), 0.0003 PF00018 SH3 domain 0.0003 PF01230 HIT domain 0.0002 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0002 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0002 PF08676 MutL C terminal dimerisation domain 0.0002 PF01119 DNA mismatch repair protein, C-terminal domain 0.0002 PF12473 Kinesin protein 0.0002 PF01437 Plexin repeat 0.0002 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0002 PF12423 Kinesin protein 1B 0.0002 PF00501 AMP-binding enzyme 0.0002 PF01833 IPT/TIG domain 0.0002 PF01403 Sema domain 0.0002 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0002 PF00498 FHA domain 0.0002 PF00794 PI3-kinase family, ras-binding domain 0.0002 PF00792 Phosphoinositide 3-kinase C2 0.0002 PF02779 Transketolase, pyrimidine binding domain 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF00962 Adenosine/AMP deaminase 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0001 PF01808 AICARFT/IMPCHase bienzyme 0.0001 PF01712 Deoxynucleoside kinase 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF06212 GRIM-19 protein 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF10276 Zinc-finger domain 0.0001 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0001 PF00400 WD domain, G-beta repeat 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF00225 Kinesin motor domain 0.0001 PF02817 e3 binding domain 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF10531 SLBB domain 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF02173 pKID domain 0.0001 PF00931 NB-ARC domain 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF08040 MNLL subunit 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF04116 Fatty acid hydroxylase superfamily SUB339 C(~C)(~C)(~H)(~N) 0.0166 PF02798 Glutathione S-transferase, N-terminal domain 0.0163 PF00043 Glutathione S-transferase, C-terminal domain 0.0099 PF00255 Glutathione peroxidase 0.0079 PF05649 Peptidase family M13 0.0079 PF01431 Peptidase family M13 0.0069 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0056 PF01124 MAPEG family 0.0052 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0049 PF00091 Tubulin/FtsZ family, GTPase domain 0.0049 PF03953 Tubulin C-terminal domain 0.0048 PF01401 Angiotensin-converting enzyme 0.0045 PF09396 Thrombin light chain 0.0044 PF03199 Eukaryotic glutathione synthase 0.0044 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0034 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0033 PF01323 DSBA-like thioredoxin domain 0.0030 PF00656 Caspase domain 0.0029 PF08983 Domain of unknown function (DUF1856), 0.0028 PF00303 Thymidylate synthase 0.0026 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0024 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0024 PF00462 Glutaredoxin 0.0023 PF07722 Peptidase C26 0.0020 PF01406 tRNA synthetases class I (C), catalytic domain 0.0019 PF01019 Gamma-glutamyltranspeptidase 0.0019 PF05995 Cysteine dioxygenase type I 0.0019 PF00756 Putative esterase 0.0017 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0017 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0016 PF03074 Glutamate-cysteine ligase 0.0016 PF00619 Caspase recruitment domain 0.0011 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0011 PF00439 Bromodomain 0.0011 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0010 PF06617 M-phase inducer phosphatase 0.0010 PF00581 Rhodanese-like domain 0.0009 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0009 PF03002 Somatostatin/Cortistatin family 0.0008 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0007 PF00806 Pumilio-family RNA binding repeat 0.0007 PF00085 Thioredoxin 0.0007 PF00778 DIX domain 0.0007 PF00822 PMP-22/EMP/MP20/Claudin family 0.0007 PF08833 Axin beta-catenin binding domain 0.0006 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0006 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0006 PF00265 Thymidine kinase 0.0005 PF00342 Phosphoglucose isomerase 0.0005 PF00931 NB-ARC domain 0.0005 PF00400 WD domain, G-beta repeat 0.0004 PF02793 Hormone receptor domain 0.0004 PF00002 7 transmembrane receptor (Secretin family), 0.0003 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF00586 AIR synthase related protein, N-terminal domain 0.0002 PF10420 Cytokine interleukin-12p40 C-terminus 0.0002 PF02769 AIR synthase related protein, C-terminal domain 0.0001 PF00108 Thiolase, N-terminal domain 0.0001 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0001 PF02803 Thiolase, C-terminal domain 0.0001 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0001 PF01471 Putative peptidoglycan binding domain 0.0001 PF00045 Hemopexin SUB663 O-C-C-O-C 0.0159 PF02806 Alpha amylase, C-terminal all-beta domain 0.0137 PF00191 Annexin 0.0125 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0118 PF02155 Glucocorticoid receptor 0.0115 PF00128 Alpha amylase, catalytic domain 0.0112 PF03414 Glycosyltransferase family 6 0.0087 PF00079 Serpin (serine protease inhibitor), 0.0067 PF01048 Phosphorylase superfamily 0.0058 PF00091 Tubulin/FtsZ family, GTPase domain 0.0058 PF03953 Tubulin C-terminal domain 0.0051 PF02223 Thymidylate kinase 0.0048 PF01735 Lysophospholipase catalytic domain 0.0041 PF00059 Lectin C-type domain 0.0040 PF00167 Fibroblast growth factor 0.0038 PF00303 Thymidylate synthase 0.0033 PF00106 short chain dehydrogenase 0.0027 PF08070 DTHCT (NUC029), region 0.0027 PF00204 DNA gyrase B 0.0027 PF00084 Sushi domain (SCR repeat), 0.0027 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0024 PF07654 Immunoglobulin C1-set domain 0.0023 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0022 PF03770 Inositol polyphosphate kinase 0.0020 PF00005 ABC transporter 0.0019 PF01607 Chitin binding Peritrophin-A domain 0.0019 PF02267 ADP-ribosyl cyclase 0.0019 PF03727 Hexokinase 0.0019 PF00349 Hexokinase 0.0019 PF00704 Glycosyl hydrolases family 18 0.0017 PF01467 Cytidylyltransferase 0.0016 PF01370 NAD dependent epimerase/dehydratase family 0.0014 PF00664 ABC transporter transmembrane region 0.0014 PF00143 Interferon alpha/beta domain 0.0014 PF00171 Aldehyde dehydrogenase family 0.0013 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0013 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0013 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0012 PF08035 Opioids neuropeptide 0.0012 PF00976 Corticotropin ACTH domain 0.0012 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.0012 PF01532 Glycosyl hydrolase family 47 0.0012 PF08384 Pro-opiomelanocortin, N-terminal region 0.0010 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0008 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0008 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0008 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0008 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0008 PF08702 Fibrinogen alpha/beta chain family 0.0007 PF08240 Alcohol dehydrogenase GroES-like domain 0.0006 PF01055 Glycosyl hydrolases family 31 0.0006 PF12160 Fibrinogen alpha C domain 0.0006 PF00088 Trefoil (P-type), domain 0.0005 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0005 PF07686 Immunoglobulin V-set domain 0.0005 PF00337 Galactoside-binding lectin 0.0005 PF00293 NUDIX domain 0.0005 PF00328 Histidine acid phosphatase 0.0005 PF02065 Melibiase 0.0004 PF00107 Zinc-binding dehydrogenase 0.0004 PF00690 Cation transporter/ATPase, N-terminus 0.0004 PF00689 Cation transporting ATPase, C-terminus 0.0004 PF04679 ATP dependent DNA ligase C terminal region 0.0004 PF00248 Aldo/keto reductase family 0.0004 PF00089 Trypsin 0.0004 PF07645 Calcium-binding EGF domain 0.0004 PF01068 ATP dependent DNA ligase domain 0.0003 PF00041 Fibronectin type III domain 0.0003 PF01687 Riboflavin kinase 0.0003 PF00431 CUB domain 0.0003 PF00122 E1-E2 ATPase 0.0003 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0003 PF00071 Ras family 0.0002 PF00058 Low-density lipoprotein receptor repeat class B 0.0002 PF00057 Low-density lipoprotein receptor domain class A 0.0002 PF01842 ACT domain 0.0002 PF00403 Heavy-metal-associated domain 0.0002 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0002 PF00031 Cystatin domain 0.0002 PF04711 Apolipoprotein A-II (ApoA-II), 0.0002 PF01122 Eukaryotic cobalamin-binding protein 0.0002 PF01230 HIT domain 0.0002 PF00024 PAN domain 0.0002 PF00702 haloacid dehalogenase-like hydrolase 0.0002 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0002 PF00571 CBS domain 0.0002 PF07648 Kazal-type serine protease inhibitor domain 0.0001 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0001 PF02055 O-Glycosyl hydrolase family 30 0.0001 PF03781 Formylglycine-generating sulfatase enzyme 0.0001 PF03360 Glycosyltransferase family 43 0.0001 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0001 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0001 PF05735 Thrombospondin C-terminal region 0.0001 PF00884 Sulfatase 0.0001 PF08516 ADAM cysteine-rich 0.0001 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0001 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0001 PF00090 Thrombospondin type 1 domain 0.0001 PF00093 von Willebrand factor type C domain 0.0001 PF00703 domain 0.0001 PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), 0.0001 PF00021 u-PAR/Ly-6 domain 0.0001 PF01562 Reprolysin family propeptide 0.0001 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0001 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0001 PF10420 Cytokine interleukin-12p40 C-terminus 0.0001 PF00236 Glycoprotein hormone 0.0001 PF00714 Interferon gamma 0.0001 PF00183 Hsp90 protein 0.0001 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 0.0001 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0001 PF01869 BadF/BadG/BcrA/BcrD ATPase family 0.0001 PF03171 2OG-Fe(II), oxygenase superfamily 0.0001 PF00200 Disintegrin 0.0001 PF01421 Reprolysin (M12B), family zinc metalloprotease SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 0.0150 PF01122 Eukaryotic cobalamin-binding protein 0.0111 PF02310 B12 binding domain 0.0105 PF01923 Cobalamin adenosyltransferase 0.0105 PF03308 ArgK protein 0.0105 PF01642 Methylmalonyl-CoA mutase 0.0050 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0050 PF02607 B12 binding domain 0.0050 PF00809 Pterin binding enzyme 0.0049 PF00431 CUB domain 0.0046 PF00667 FAD binding domain 0.0046 PF00258 Flavodoxin 0.0045 PF00175 Oxidoreductase NAD-binding domain 0.0032 PF07645 Calcium-binding EGF domain 0.0026 PF02574 Homocysteine S-methyltransferase 0.0014 PF02223 Thymidylate kinase 0.0013 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0012 PF08240 Alcohol dehydrogenase GroES-like domain 0.0011 PF00106 short chain dehydrogenase 0.0010 PF00478 IMP dehydrogenase / GMP reductase domain 0.0010 PF00107 Zinc-binding dehydrogenase 0.0009 PF01126 Heme oxygenase 0.0009 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0009 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0009 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0009 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0008 PF00571 CBS domain 0.0008 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0008 PF00171 Aldehyde dehydrogenase family 0.0008 PF00248 Aldo/keto reductase family 0.0008 PF02267 ADP-ribosyl cyclase 0.0008 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0007 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0007 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0006 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0006 PF01467 Cytidylyltransferase 0.0006 PF00970 Oxidoreductase FAD-binding domain 0.0006 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0005 PF02233 NAD(P), transhydrogenase beta subunit 0.0005 PF01652 Eukaryotic initiation factor 4E 0.0005 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0005 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0005 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0005 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0004 PF03770 Inositol polyphosphate kinase 0.0004 PF00676 Dehydrogenase E1 component 0.0004 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0004 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0004 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0004 PF03949 Malic enzyme, NAD binding domain 0.0004 PF01687 Riboflavin kinase 0.0004 PF02036 SCP-2 sterol transfer family 0.0004 PF00390 Malic enzyme, N-terminal domain 0.0004 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0004 PF01268 Formate--tetrahydrofolate ligase 0.0004 PF01370 NAD dependent epimerase/dehydratase family 0.0004 PF01575 MaoC like domain 0.0004 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0004 PF00057 Low-density lipoprotein receptor domain class A 0.0004 PF00058 Low-density lipoprotein receptor repeat class B 0.0004 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0003 PF00348 Polyprenyl synthetase 0.0003 PF02525 Flavodoxin-like fold 0.0003 PF00186 Dihydrofolate reductase 0.0003 PF00069 Protein kinase domain 0.0003 PF00018 SH3 domain 0.0003 PF00017 SH2 domain 0.0003 PF01230 HIT domain 0.0002 PF02779 Transketolase, pyrimidine binding domain 0.0002 PF00501 AMP-binding enzyme 0.0002 PF05347 Complex 1 protein (LYR family), 0.0002 PF01403 Sema domain 0.0002 PF12423 Kinesin protein 1B 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF00498 FHA domain 0.0002 PF01833 IPT/TIG domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF01119 DNA mismatch repair protein, C-terminal domain 0.0002 PF01437 Plexin repeat 0.0002 PF08676 MutL C terminal dimerisation domain 0.0002 PF00378 Enoyl-CoA hydratase/isomerase family 0.0002 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0002 PF12473 Kinesin protein 0.0002 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF10531 SLBB domain 0.0001 PF10276 Zinc-finger domain 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0001 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF00794 PI3-kinase family, ras-binding domain 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF00792 Phosphoinositide 3-kinase C2 0.0001 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF00225 Kinesin motor domain 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF06212 GRIM-19 protein 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF08040 MNLL subunit 0.0001 PF00931 NB-ARC domain 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF02173 pKID domain 0.0001 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF00400 WD domain, G-beta repeat 0.0001 PF02817 e3 binding domain 0.0001 PF01712 Deoxynucleoside kinase 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF01808 AICARFT/IMPCHase bienzyme 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF02466 Tim17/Tim22/Tim23 family SUB387 C(:C)(:C)(:N) 0.0125 PF01122 Eukaryotic cobalamin-binding protein 0.0093 PF02310 B12 binding domain 0.0088 PF01642 Methylmalonyl-CoA mutase 0.0088 PF01923 Cobalamin adenosyltransferase 0.0088 PF03308 ArgK protein 0.0042 PF00809 Pterin binding enzyme 0.0042 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0042 PF02607 B12 binding domain 0.0041 PF00431 CUB domain 0.0038 PF00667 FAD binding domain 0.0038 PF00175 Oxidoreductase NAD-binding domain 0.0038 PF00258 Flavodoxin 0.0027 PF07645 Calcium-binding EGF domain 0.0021 PF02574 Homocysteine S-methyltransferase 0.0012 PF02223 Thymidylate kinase 0.0011 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0010 PF08240 Alcohol dehydrogenase GroES-like domain 0.0009 PF00106 short chain dehydrogenase 0.0009 PF00107 Zinc-binding dehydrogenase 0.0009 PF00478 IMP dehydrogenase / GMP reductase domain 0.0008 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0008 PF01126 Heme oxygenase 0.0007 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0007 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0007 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0007 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0007 PF00248 Aldo/keto reductase family 0.0007 PF02267 ADP-ribosyl cyclase 0.0007 PF00171 Aldehyde dehydrogenase family 0.0007 PF00571 CBS domain 0.0007 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0006 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0006 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0005 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF01467 Cytidylyltransferase 0.0005 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0005 PF00970 Oxidoreductase FAD-binding domain 0.0004 PF02036 SCP-2 sterol transfer family 0.0004 PF01652 Eukaryotic initiation factor 4E 0.0004 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0004 PF03770 Inositol polyphosphate kinase 0.0004 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0004 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0004 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0004 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0004 PF01575 MaoC like domain 0.0004 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0004 PF02233 NAD(P), transhydrogenase beta subunit 0.0004 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0004 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0003 PF00017 SH2 domain 0.0003 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0003 PF03949 Malic enzyme, NAD binding domain 0.0003 PF00058 Low-density lipoprotein receptor repeat class B 0.0003 PF00057 Low-density lipoprotein receptor domain class A 0.0003 PF00348 Polyprenyl synthetase 0.0003 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0003 PF01268 Formate--tetrahydrofolate ligase 0.0003 PF00676 Dehydrogenase E1 component 0.0003 PF01370 NAD dependent epimerase/dehydratase family 0.0003 PF01687 Riboflavin kinase 0.0003 PF00390 Malic enzyme, N-terminal domain 0.0003 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0003 PF02525 Flavodoxin-like fold 0.0003 PF00069 Protein kinase domain 0.0003 PF00186 Dihydrofolate reductase 0.0002 PF02779 Transketolase, pyrimidine binding domain 0.0002 PF01230 HIT domain 0.0002 PF01403 Sema domain 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0002 PF01833 IPT/TIG domain 0.0002 PF00378 Enoyl-CoA hydratase/isomerase family 0.0002 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0002 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0002 PF05347 Complex 1 protein (LYR family), 0.0002 PF01437 Plexin repeat 0.0002 PF00018 SH3 domain 0.0002 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF12423 Kinesin protein 1B 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF10531 SLBB domain 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF00501 AMP-binding enzyme 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF00400 WD domain, G-beta repeat 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF00794 PI3-kinase family, ras-binding domain 0.0001 PF00792 Phosphoinositide 3-kinase C2 0.0001 PF01119 DNA mismatch repair protein, C-terminal domain 0.0001 PF08676 MutL C terminal dimerisation domain 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF10276 Zinc-finger domain 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF12473 Kinesin protein 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0001 PF02817 e3 binding domain 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF08040 MNLL subunit 0.0001 PF00225 Kinesin motor domain 0.0001 PF01712 Deoxynucleoside kinase 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0001 PF06212 GRIM-19 protein 0.0001 PF00931 NB-ARC domain 0.0001 PF00498 FHA domain 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF01808 AICARFT/IMPCHase bienzyme SUB567 O-C-C-N 0.0115 PF02798 Glutathione S-transferase, N-terminal domain 0.0112 PF00043 Glutathione S-transferase, C-terminal domain 0.0068 PF00255 Glutathione peroxidase 0.0055 PF05649 Peptidase family M13 0.0055 PF01431 Peptidase family M13 0.0048 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0038 PF01124 MAPEG family 0.0036 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0034 PF00091 Tubulin/FtsZ family, GTPase domain 0.0034 PF03953 Tubulin C-terminal domain 0.0033 PF01401 Angiotensin-converting enzyme 0.0031 PF09396 Thrombin light chain 0.0030 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0030 PF03199 Eukaryotic glutathione synthase 0.0023 PF01323 DSBA-like thioredoxin domain 0.0023 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0021 PF00656 Caspase domain 0.0020 PF08983 Domain of unknown function (DUF1856), 0.0019 PF00303 Thymidylate synthase 0.0018 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0017 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0017 PF00462 Glutaredoxin 0.0016 PF07722 Peptidase C26 0.0014 PF01406 tRNA synthetases class I (C), catalytic domain 0.0013 PF01019 Gamma-glutamyltranspeptidase 0.0013 PF00756 Putative esterase 0.0013 PF05995 Cysteine dioxygenase type I 0.0012 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0012 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0011 PF00619 Caspase recruitment domain 0.0011 PF03074 Glutamate-cysteine ligase 0.0008 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0007 PF06617 M-phase inducer phosphatase 0.0007 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0007 PF00581 Rhodanese-like domain 0.0007 PF00439 Bromodomain 0.0006 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0006 PF03002 Somatostatin/Cortistatin family 0.0006 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0005 PF00806 Pumilio-family RNA binding repeat 0.0005 PF00085 Thioredoxin 0.0005 PF00778 DIX domain 0.0005 PF00822 PMP-22/EMP/MP20/Claudin family 0.0005 PF08833 Axin beta-catenin binding domain 0.0004 PF00265 Thymidine kinase 0.0004 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0004 PF00931 NB-ARC domain 0.0004 PF00342 Phosphoglucose isomerase 0.0004 PF00400 WD domain, G-beta repeat 0.0004 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0003 PF00002 7 transmembrane receptor (Secretin family), 0.0003 PF02793 Hormone receptor domain 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0001 PF02803 Thiolase, C-terminal domain 0.0001 PF02769 AIR synthase related protein, C-terminal domain 0.0001 PF00045 Hemopexin 0.0001 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0001 PF00108 Thiolase, N-terminal domain 0.0001 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0001 PF00586 AIR synthase related protein, N-terminal domain 0.0001 PF01471 Putative peptidoglycan binding domain 0.0001 PF10420 Cytokine interleukin-12p40 C-terminus SUB660 O-C-C-N-C 0.0099 PF02798 Glutathione S-transferase, N-terminal domain 0.0097 PF00043 Glutathione S-transferase, C-terminal domain 0.0059 PF00255 Glutathione peroxidase 0.0047 PF05649 Peptidase family M13 0.0047 PF01431 Peptidase family M13 0.0041 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0033 PF01124 MAPEG family 0.0031 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0029 PF03953 Tubulin C-terminal domain 0.0029 PF00091 Tubulin/FtsZ family, GTPase domain 0.0028 PF01401 Angiotensin-converting enzyme 0.0027 PF09396 Thrombin light chain 0.0026 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.0026 PF03199 Eukaryotic glutathione synthase 0.0020 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0020 PF01323 DSBA-like thioredoxin domain 0.0018 PF00656 Caspase domain 0.0017 PF08983 Domain of unknown function (DUF1856), 0.0017 PF00303 Thymidylate synthase 0.0015 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0014 PF00462 Glutaredoxin 0.0014 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0014 PF07722 Peptidase C26 0.0012 PF01406 tRNA synthetases class I (C), catalytic domain 0.0011 PF05995 Cysteine dioxygenase type I 0.0011 PF01019 Gamma-glutamyltranspeptidase 0.0011 PF00756 Putative esterase 0.0010 PF00619 Caspase recruitment domain 0.0010 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 0.0010 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0009 PF03074 Glutamate-cysteine ligase 0.0007 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0006 PF06617 M-phase inducer phosphatase 0.0006 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 0.0006 PF00439 Bromodomain 0.0006 PF00581 Rhodanese-like domain 0.0005 PF01053 Cys/Met metabolism PLP-dependent enzyme 0.0005 PF03002 Somatostatin/Cortistatin family 0.0005 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0004 PF01243 Pyridoxamine 5"-phosphate oxidase 0.0004 PF00822 PMP-22/EMP/MP20/Claudin family 0.0004 PF00085 Thioredoxin 0.0004 PF08833 Axin beta-catenin binding domain 0.0004 PF00265 Thymidine kinase 0.0004 PF00778 DIX domain 0.0004 PF00806 Pumilio-family RNA binding repeat 0.0004 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 0.0003 PF00931 NB-ARC domain 0.0003 PF00342 Phosphoglucose isomerase 0.0003 PF00400 WD domain, G-beta repeat 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF00002 7 transmembrane receptor (Secretin family), 0.0002 PF02793 Hormone receptor domain 0.0001 PF01471 Putative peptidoglycan binding domain 0.0001 PF00045 Hemopexin 0.0001 PF02803 Thiolase, C-terminal domain 0.0001 PF00108 Thiolase, N-terminal domain 0.0001 PF10420 Cytokine interleukin-12p40 C-terminus 0.0001 PF00586 AIR synthase related protein, N-terminal domain 0.0001 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0001 PF02769 AIR synthase related protein, C-terminal domain 0.0001 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain SUB358 C(~C)(:C)(:N) 0.0092 PF00227 Proteasome subunit 0.0013 PF01048 Phosphorylase superfamily 0.0011 PF00069 Protein kinase domain 0.0010 PF00478 IMP dehydrogenase / GMP reductase domain 0.0010 PF00186 Dihydrofolate reductase 0.0008 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0007 PF00571 CBS domain 0.0007 PF00962 Adenosine/AMP deaminase 0.0006 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0005 PF08240 Alcohol dehydrogenase GroES-like domain 0.0005 PF00107 Zinc-binding dehydrogenase 0.0005 PF00156 Phosphoribosyl transferase domain 0.0004 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0004 PF01590 GAF domain 0.0004 PF00106 short chain dehydrogenase 0.0004 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0004 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0003 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0003 PF00858 Amiloride-sensitive sodium channel 0.0003 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0003 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0003 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0003 PF01467 Cytidylyltransferase 0.0003 PF00018 SH3 domain 0.0003 PF00017 SH2 domain 0.0003 PF00171 Aldehyde dehydrogenase family 0.0002 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0002 PF00498 FHA domain 0.0002 PF12423 Kinesin protein 1B 0.0002 PF01575 MaoC like domain 0.0002 PF08919 F-actin binding 0.0002 PF01122 Eukaryotic cobalamin-binding protein 0.0002 PF10397 Adenylosuccinate lyase C-terminus 0.0002 PF01126 Heme oxygenase 0.0002 PF08676 MutL C terminal dimerisation domain 0.0002 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0002 PF01119 DNA mismatch repair protein, C-terminal domain 0.0002 PF02036 SCP-2 sterol transfer family 0.0002 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0002 PF00501 AMP-binding enzyme 0.0002 PF01652 Eukaryotic initiation factor 4E 0.0002 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0002 PF08996 DNA Polymerase alpha zinc finger 0.0002 PF03104 DNA polymerase family B, exonuclease domain 0.0002 PF00821 Phosphoenolpyruvate carboxykinase 0.0002 PF01230 HIT domain 0.0002 PF00970 Oxidoreductase FAD-binding domain 0.0002 PF12473 Kinesin protein 0.0002 PF02223 Thymidylate kinase 0.0002 PF00136 DNA polymerase family B 0.0002 PF00225 Kinesin motor domain 0.0001 PF00071 Ras family 0.0001 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF00536 SAM domain (Sterile alpha motif), 0.0001 PF00533 BRCA1 C Terminus (BRCT), domain 0.0001 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0001 PF03949 Malic enzyme, NAD binding domain 0.0001 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.0001 PF00676 Dehydrogenase E1 component 0.0001 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0001 PF00757 Furin-like cysteine rich region 0.0001 PF01404 Ephrin receptor ligand binding domain 0.0001 PF00400 WD domain, G-beta repeat 0.0001 PF05406 WGR domain 0.0001 PF02233 NAD(P), transhydrogenase beta subunit 0.0001 PF08515 Transforming growth factor beta type I GS-motif 0.0001 PF01064 Activin types I and II receptor domain 0.0001 PF01068 ATP dependent DNA ligase domain 0.0001 PF00690 Cation transporter/ATPase, N-terminus 0.0001 PF01712 Deoxynucleoside kinase 0.0001 PF07966 A1 Propeptide 0.0001 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0001 PF03770 Inositol polyphosphate kinase 0.0001 PF00390 Malic enzyme, N-terminal domain 0.0001 PF02267 ADP-ribosyl cyclase 0.0001 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0001 PF00248 Aldo/keto reductase family 0.0001 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 0.0001 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0001 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0001 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0001 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0001 PF03024 Folate receptor family 0.0001 PF00689 Cation transporting ATPase, C-terminus 0.0001 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0001 PF00702 haloacid dehalogenase-like hydrolase 0.0001 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0001 PF01642 Methylmalonyl-CoA mutase 0.0001 PF01268 Formate--tetrahydrofolate ligase 0.0001 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0001 PF04679 ATP dependent DNA ligase C terminal region 0.0001 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 0.0001 PF02779 Transketolase, pyrimidine binding domain 0.0001 PF00042 Globin 0.0001 PF01808 AICARFT/IMPCHase bienzyme 0.0001 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0001 PF00206 Lyase 0.0001 PF05347 Complex 1 protein (LYR family), 0.0001 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0001 PF08063 PADR1 (NUC008), domain 0.0001 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.0001 PF00025 ADP-ribosylation factor family 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF11555 EGFR receptor inhibitor Mig-6 0.0001 PF03073 TspO/MBR family 0.0001 PF00931 NB-ARC domain 0.0001 PF00122 E1-E2 ATPase 0.0001 PF02310 B12 binding domain 0.0001 PF00378 Enoyl-CoA hydratase/isomerase family 0.0001 PF00334 Nucleoside diphosphate kinase 0.0001 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0001 PF03308 ArgK protein 0.0001 PF01030 Receptor L domain 0.0001 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0001 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0001 PF00644 Poly(ADP-ribose), polymerase catalytic domain 0.0001 PF00317 Ribonucleotide reductase, all-alpha domain 0.0001 PF00310 Glutamine amidotransferases class-II 0.0001 PF09027 GTPase binding 0.0001 PF00958 GMP synthase C terminal domain 0.0001 PF02867 Ribonucleotide reductase, barrel domain 0.0001 PF03477 ATP cone domain 0.0001 PF01923 Cobalamin adenosyltransferase 0.0001 PF02525 Flavodoxin-like fold SUB107 >= 1 Gd 0.0091 PF00273 Serum albumin family 0.0071 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0066 PF08534 Redoxin 0.0035 PF00854 POT family 0.0019 PF09396 Thrombin light chain 0.0016 PF02180 Bcl-2 homology region 4 0.0016 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0012 PF02460 Patched family 0.0012 PF00151 Lipase 0.0012 PF03062 MBOAT family 0.0012 PF01731 Arylesterase 0.0010 PF00069 Protein kinase domain 0.0008 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0008 PF00975 Thioesterase domain 0.0008 PF00698 Acyl transferase domain 0.0008 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0008 PF05649 Peptidase family M13 0.0008 PF01401 Angiotensin-converting enzyme 0.0008 PF01431 Peptidase family M13 0.0008 PF08659 KR domain 0.0007 PF01433 Peptidase family M1 0.0007 PF01477 PLAT/LH2 domain 0.0006 PF00051 Kringle domain 0.0006 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0005 PF00576 HIUase/Transthyretin family 0.0004 PF00343 Carbohydrate phosphorylase 0.0004 PF12126 Protein of unknown function (DUF3583), 0.0004 PF00059 Lectin C-type domain 0.0004 PF00134 Cyclin, N-terminal domain 0.0004 PF00091 Tubulin/FtsZ family, GTPase domain 0.0004 PF03957 Jun-like transcription factor 0.0004 PF00550 Phosphopantetheine attachment site 0.0004 PF03953 Tubulin C-terminal domain 0.0004 PF02984 Cyclin, C-terminal domain 0.0004 PF07970 Endoplasmic reticulum vesicle transporter 0.0003 PF02423 Ornithine cyclodeaminase/mu-crystallin family 0.0003 PF00489 Interleukin-6/G-CSF/MGF family 0.0003 PF07645 Calcium-binding EGF domain 0.0003 PF00664 ABC transporter transmembrane region 0.0002 PF00643 B-box zinc finger 0.0002 PF00005 ABC transporter 0.0002 PF00107 Zinc-binding dehydrogenase 0.0002 PF00170 bZIP transcription factor 0.0001 PF00433 Protein kinase C terminal domain 0.0001 PF00089 Trypsin SUB94 >= 1 Pt 0.0091 PF00273 Serum albumin family 0.0071 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0066 PF08534 Redoxin 0.0035 PF00854 POT family 0.0019 PF09396 Thrombin light chain 0.0016 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0016 PF02180 Bcl-2 homology region 4 0.0012 PF02460 Patched family 0.0012 PF03062 MBOAT family 0.0012 PF00151 Lipase 0.0012 PF01731 Arylesterase 0.0010 PF00069 Protein kinase domain 0.0008 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0008 PF00698 Acyl transferase domain 0.0008 PF08659 KR domain 0.0008 PF01401 Angiotensin-converting enzyme 0.0008 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0008 PF05649 Peptidase family M13 0.0008 PF00975 Thioesterase domain 0.0008 PF01431 Peptidase family M13 0.0007 PF01477 PLAT/LH2 domain 0.0007 PF01433 Peptidase family M1 0.0006 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0006 PF00051 Kringle domain 0.0005 PF00576 HIUase/Transthyretin family 0.0004 PF00343 Carbohydrate phosphorylase 0.0004 PF03957 Jun-like transcription factor 0.0004 PF03953 Tubulin C-terminal domain 0.0004 PF00059 Lectin C-type domain 0.0004 PF00134 Cyclin, N-terminal domain 0.0004 PF00091 Tubulin/FtsZ family, GTPase domain 0.0004 PF07970 Endoplasmic reticulum vesicle transporter 0.0004 PF00550 Phosphopantetheine attachment site 0.0004 PF12126 Protein of unknown function (DUF3583), 0.0004 PF02984 Cyclin, C-terminal domain 0.0003 PF00489 Interleukin-6/G-CSF/MGF family 0.0003 PF02423 Ornithine cyclodeaminase/mu-crystallin family 0.0003 PF00664 ABC transporter transmembrane region 0.0003 PF07645 Calcium-binding EGF domain 0.0002 PF00170 bZIP transcription factor 0.0002 PF00643 B-box zinc finger 0.0002 PF00107 Zinc-binding dehydrogenase 0.0002 PF00005 ABC transporter 0.0001 PF00433 Protein kinase C terminal domain 0.0001 PF00089 Trypsin SUB701 O-C-C-C-C-C-O-C 0.0084 PF02806 Alpha amylase, C-terminal all-beta domain 0.0067 PF00128 Alpha amylase, catalytic domain 0.0066 PF03414 Glycosyltransferase family 6 0.0055 PF00204 DNA gyrase B 0.0055 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0055 PF08070 DTHCT (NUC029), region 0.0029 PF00059 Lectin C-type domain 0.0029 PF00079 Serpin (serine protease inhibitor), 0.0027 PF00167 Fibroblast growth factor 0.0027 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0026 PF00084 Sushi domain (SCR repeat), 0.0023 PF07654 Immunoglobulin C1-set domain 0.0021 PF00143 Interferon alpha/beta domain 0.0017 PF08702 Fibrinogen alpha/beta chain family 0.0017 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.0015 PF02155 Glucocorticoid receptor 0.0013 PF12160 Fibrinogen alpha C domain 0.0012 PF00349 Hexokinase 0.0012 PF00088 Trefoil (P-type), domain 0.0012 PF01055 Glycosyl hydrolases family 31 0.0012 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.0012 PF03727 Hexokinase 0.0012 PF01735 Lysophospholipase catalytic domain 0.0011 PF07686 Immunoglobulin V-set domain 0.0011 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.0011 PF02065 Melibiase 0.0011 PF00293 NUDIX domain 0.0010 PF00337 Galactoside-binding lectin 0.0010 PF00328 Histidine acid phosphatase 0.0009 PF00689 Cation transporting ATPase, C-terminus 0.0009 PF00690 Cation transporter/ATPase, N-terminus 0.0009 PF02267 ADP-ribosyl cyclase 0.0009 PF07645 Calcium-binding EGF domain 0.0008 PF01068 ATP dependent DNA ligase domain 0.0008 PF00089 Trypsin 0.0008 PF01370 NAD dependent epimerase/dehydratase family 0.0008 PF04679 ATP dependent DNA ligase C terminal region 0.0007 PF00122 E1-E2 ATPase 0.0007 PF00041 Fibronectin type III domain 0.0006 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 0.0006 PF00431 CUB domain 0.0005 PF00702 haloacid dehalogenase-like hydrolase 0.0004 PF04711 Apolipoprotein A-II (ApoA-II), 0.0004 PF00385 chromo (CHRromatin Organisation MOdifier), domain 0.0004 PF01532 Glycosyl hydrolase family 47 0.0004 PF00403 Heavy-metal-associated domain 0.0004 PF00031 Cystatin domain 0.0004 PF00024 PAN domain 0.0004 PF03662 Glycosyl hydrolase family 79, N-terminal domain 0.0003 PF07648 Kazal-type serine protease inhibitor domain 0.0003 PF00884 Sulfatase 0.0003 PF00191 Annexin 0.0003 PF00057 Low-density lipoprotein receptor domain class A 0.0003 PF00058 Low-density lipoprotein receptor repeat class B 0.0002 PF02055 O-Glycosyl hydrolase family 30 0.0002 PF09014 Beta-2-glycoprotein-1 fifth domain 0.0002 PF02837 Glycosyl hydrolases family 2, sugar binding domain 0.0002 PF02836 Glycosyl hydrolases family 2, TIM barrel domain 0.0002 PF01869 BadF/BadG/BcrA/BcrD ATPase family 0.0002 PF00714 Interferon gamma 0.0002 PF00200 Disintegrin 0.0002 PF09006 Lung surfactant protein D coiled-coil trimerisation 0.0002 PF08516 ADAM cysteine-rich 0.0002 PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), 0.0002 PF00236 Glycoprotein hormone 0.0002 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 0.0002 PF01421 Reprolysin (M12B), family zinc metalloprotease 0.0002 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0002 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0002 PF03781 Formylglycine-generating sulfatase enzyme 0.0002 PF00183 Hsp90 protein 0.0002 PF00090 Thrombospondin type 1 domain 0.0002 PF00093 von Willebrand factor type C domain 0.0002 PF03171 2OG-Fe(II), oxygenase superfamily 0.0002 PF01704 UTP--glucose-1-phosphate uridylyltransferase 0.0002 PF01562 Reprolysin family propeptide 0.0002 PF00703 domain 0.0002 PF00021 u-PAR/Ly-6 domain 0.0002 PF05735 Thrombospondin C-terminal region 0.0001 PF08718 Glycolipid transfer protein (GLTP), 0.0001 PF07884 Vitamin K epoxide reductase family 0.0001 PF10420 Cytokine interleukin-12p40 C-terminus 0.0001 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase SUB153 >= 2 saturated or aromatic nitrogen-containing ring size 5 0.0084 PF01122 Eukaryotic cobalamin-binding protein 0.0062 PF02310 B12 binding domain 0.0059 PF03308 ArgK protein 0.0059 PF01642 Methylmalonyl-CoA mutase 0.0059 PF01923 Cobalamin adenosyltransferase 0.0028 PF00431 CUB domain 0.0028 PF02607 B12 binding domain 0.0028 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0028 PF00809 Pterin binding enzyme 0.0026 PF00258 Flavodoxin 0.0026 PF00667 FAD binding domain 0.0025 PF00175 Oxidoreductase NAD-binding domain 0.0018 PF07645 Calcium-binding EGF domain 0.0014 PF02574 Homocysteine S-methyltransferase 0.0008 PF02223 Thymidylate kinase 0.0007 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0007 PF08240 Alcohol dehydrogenase GroES-like domain 0.0006 PF00478 IMP dehydrogenase / GMP reductase domain 0.0006 PF00106 short chain dehydrogenase 0.0006 PF00107 Zinc-binding dehydrogenase 0.0005 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0005 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0005 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0005 PF00171 Aldehyde dehydrogenase family 0.0005 PF01126 Heme oxygenase 0.0005 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0005 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0005 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0004 PF00571 CBS domain 0.0004 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0004 PF02267 ADP-ribosyl cyclase 0.0004 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0004 PF00248 Aldo/keto reductase family 0.0004 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0003 PF01652 Eukaryotic initiation factor 4E 0.0003 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0003 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0003 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0003 PF02233 NAD(P), transhydrogenase beta subunit 0.0003 PF00970 Oxidoreductase FAD-binding domain 0.0003 PF01467 Cytidylyltransferase 0.0003 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0003 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0002 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0002 PF00186 Dihydrofolate reductase 0.0002 PF01268 Formate--tetrahydrofolate ligase 0.0002 PF00018 SH3 domain 0.0002 PF00017 SH2 domain 0.0002 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0002 PF03949 Malic enzyme, NAD binding domain 0.0002 PF01575 MaoC like domain 0.0002 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0002 PF00348 Polyprenyl synthetase 0.0002 PF03770 Inositol polyphosphate kinase 0.0002 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0002 PF00676 Dehydrogenase E1 component 0.0002 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0002 PF00069 Protein kinase domain 0.0002 PF02525 Flavodoxin-like fold 0.0002 PF02036 SCP-2 sterol transfer family 0.0002 PF01687 Riboflavin kinase 0.0002 PF01370 NAD dependent epimerase/dehydratase family 0.0002 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0002 PF00058 Low-density lipoprotein receptor repeat class B 0.0002 PF00057 Low-density lipoprotein receptor domain class A 0.0002 PF00390 Malic enzyme, N-terminal domain 0.0001 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 0.0001 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 0.0001 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 0.0001 PF04800 ETC complex I subunit conserved region 0.0001 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 0.0001 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 0.0001 PF09326 Domain of unknown function (DUF1982), 0.0001 PF02817 e3 binding domain 0.0001 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 0.0001 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 0.0001 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 0.0001 PF01833 IPT/TIG domain 0.0001 PF09166 Biliverdin reductase, catalytic 0.0001 PF09040 Gastric H+/K+-ATPase, N terminal domain 0.0001 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 0.0001 PF06212 GRIM-19 protein 0.0001 PF08040 MNLL subunit 0.0001 PF12473 Kinesin protein 0.0001 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 0.0001 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 0.0001 PF01403 Sema domain 0.0001 PF00400 WD domain, G-beta repeat 0.0001 PF01808 AICARFT/IMPCHase bienzyme 0.0001 PF02779 Transketolase, pyrimidine binding domain 0.0001 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 0.0001 PF05347 Complex 1 protein (LYR family), 0.0001 PF10531 SLBB domain 0.0001 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 0.0001 PF01712 Deoxynucleoside kinase 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 0.0001 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 0.0001 PF01119 DNA mismatch repair protein, C-terminal domain 0.0001 PF00662 NADH-Ubiquinone oxidoreductase (complex I), , chain 5 N-terminus 0.0001 PF02466 Tim17/Tim22/Tim23 family 0.0001 PF04716 ETC complex I subunit conserved region 0.0001 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 0.0001 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 0.0001 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 0.0001 PF01230 HIT domain 0.0001 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 0.0001 PF00498 FHA domain 0.0001 PF10276 Zinc-finger domain 0.0001 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 0.0001 PF00378 Enoyl-CoA hydratase/isomerase family 0.0001 PF00501 AMP-binding enzyme 0.0001 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 0.0001 PF04116 Fatty acid hydroxylase superfamily 0.0001 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0001 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 0.0001 PF01437 Plexin repeat 0.0001 PF06444 NADH dehydrogenase subunit 2 C-terminus 0.0001 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 0.0001 PF00225 Kinesin motor domain 0.0001 PF00931 NB-ARC domain 0.0001 PF00792 Phosphoinositide 3-kinase C2 0.0001 PF00794 PI3-kinase family, ras-binding domain 0.0001 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0001 PF12423 Kinesin protein 1B 0.0001 PF06455 NADH dehydrogenase subunit 5 C-terminus 0.0001 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 0.0001 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 0.0001 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus 0.0001 PF08676 MutL C terminal dimerisation domain 0.0001 PF00384 Molybdopterin oxidoreductase 0.0001 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0001 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 0.0001 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain SUB99 >= 1 Bi 0.0069 PF00273 Serum albumin family 0.0053 PF12179 I-kappa-kinase-beta NEMO binding domain 0.0050 PF08534 Redoxin 0.0026 PF00854 POT family 0.0014 PF09396 Thrombin light chain 0.0012 PF02180 Bcl-2 homology region 4 0.0012 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.0009 PF03062 MBOAT family 0.0009 PF00151 Lipase 0.0009 PF02460 Patched family 0.0009 PF01731 Arylesterase 0.0007 PF00069 Protein kinase domain 0.0006 PF00109 Beta-ketoacyl synthase, N-terminal domain 0.0006 PF00698 Acyl transferase domain 0.0006 PF05649 Peptidase family M13 0.0006 PF01431 Peptidase family M13 0.0006 PF00975 Thioesterase domain 0.0006 PF08659 KR domain 0.0006 PF01401 Angiotensin-converting enzyme 0.0006 PF02801 Beta-ketoacyl synthase, C-terminal domain 0.0005 PF01433 Peptidase family M1 0.0005 PF01477 PLAT/LH2 domain 0.0004 PF00051 Kringle domain 0.0004 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0003 PF07970 Endoplasmic reticulum vesicle transporter 0.0003 PF00550 Phosphopantetheine attachment site 0.0003 PF00343 Carbohydrate phosphorylase 0.0003 PF00091 Tubulin/FtsZ family, GTPase domain 0.0003 PF02984 Cyclin, C-terminal domain 0.0003 PF00134 Cyclin, N-terminal domain 0.0003 PF00059 Lectin C-type domain 0.0003 PF03953 Tubulin C-terminal domain 0.0003 PF03957 Jun-like transcription factor 0.0003 PF00489 Interleukin-6/G-CSF/MGF family 0.0003 PF00576 HIUase/Transthyretin family 0.0003 PF12126 Protein of unknown function (DUF3583), 0.0002 PF00664 ABC transporter transmembrane region 0.0002 PF00170 bZIP transcription factor 0.0002 PF07645 Calcium-binding EGF domain 0.0002 PF00005 ABC transporter 0.0002 PF02423 Ornithine cyclodeaminase/mu-crystallin family 0.0002 PF00107 Zinc-binding dehydrogenase 0.0001 PF00433 Protein kinase C terminal domain 0.0001 PF00643 B-box zinc finger 0.0001 PF00089 Trypsin SUB337 C(~C)(~C)(~C)(~N) 0.0052 PF01122 Eukaryotic cobalamin-binding protein 0.0038 PF02310 B12 binding domain 0.0036 PF01642 Methylmalonyl-CoA mutase 0.0036 PF01923 Cobalamin adenosyltransferase 0.0036 PF03308 ArgK protein 0.0017 PF00809 Pterin binding enzyme 0.0017 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0017 PF00431 CUB domain 0.0017 PF02607 B12 binding domain 0.0016 PF00258 Flavodoxin 0.0016 PF00175 Oxidoreductase NAD-binding domain 0.0016 PF00667 FAD binding domain 0.0011 PF07645 Calcium-binding EGF domain 0.0009 PF02574 Homocysteine S-methyltransferase 0.0005 PF02223 Thymidylate kinase 0.0004 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0004 PF08240 Alcohol dehydrogenase GroES-like domain 0.0004 PF00107 Zinc-binding dehydrogenase 0.0004 PF00106 short chain dehydrogenase 0.0004 PF00478 IMP dehydrogenase / GMP reductase domain 0.0003 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0003 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0003 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0003 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0003 PF00571 CBS domain 0.0003 PF00171 Aldehyde dehydrogenase family 0.0003 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0003 PF02267 ADP-ribosyl cyclase 0.0003 PF00248 Aldo/keto reductase family 0.0003 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0003 PF01126 Heme oxygenase 0.0003 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0003 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0002 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0002 PF02233 NAD(P), transhydrogenase beta subunit 0.0002 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0002 PF01652 Eukaryotic initiation factor 4E 0.0002 PF01467 Cytidylyltransferase 0.0002 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0002 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0002 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0002 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0002 PF00970 Oxidoreductase FAD-binding domain 0.0002 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0001 PF02779 Transketolase, pyrimidine binding domain 0.0001 PF02036 SCP-2 sterol transfer family 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0001 PF12423 Kinesin protein 1B 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF03949 Malic enzyme, NAD binding domain 0.0001 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0001 PF05347 Complex 1 protein (LYR family), 0.0001 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0001 PF01437 Plexin repeat 0.0001 PF01833 IPT/TIG domain 0.0001 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0001 PF00390 Malic enzyme, N-terminal domain 0.0001 PF02525 Flavodoxin-like fold 0.0001 PF00186 Dihydrofolate reductase 0.0001 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0001 PF03770 Inositol polyphosphate kinase 0.0001 PF01230 HIT domain 0.0001 PF00018 SH3 domain 0.0001 PF00017 SH2 domain 0.0001 PF00058 Low-density lipoprotein receptor repeat class B 0.0001 PF00057 Low-density lipoprotein receptor domain class A 0.0001 PF00498 FHA domain 0.0001 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0001 PF08676 MutL C terminal dimerisation domain 0.0001 PF00501 AMP-binding enzyme 0.0001 PF01687 Riboflavin kinase 0.0001 PF00069 Protein kinase domain 0.0001 PF01119 DNA mismatch repair protein, C-terminal domain 0.0001 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0001 PF00378 Enoyl-CoA hydratase/isomerase family 0.0001 PF12473 Kinesin protein 0.0001 PF01575 MaoC like domain 0.0001 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0001 PF01403 Sema domain 0.0001 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0001 PF00348 Polyprenyl synthetase 0.0001 PF01268 Formate--tetrahydrofolate ligase 0.0001 PF00676 Dehydrogenase E1 component SUB361 C(~Cl)(~Cl) 0.0040 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.0039 PF00146 NADH dehydrogenase 0.0026 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0026 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0025 PF02254 TrkA-N domain 0.0025 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0018 PF00689 Cation transporting ATPase, C-terminus 0.0018 PF02888 Calmodulin binding domain 0.0018 PF00690 Cation transporter/ATPase, N-terminus 0.0018 PF00631 GGL domain 0.0018 PF03530 Calcium-activated SK potassium channel 0.0018 PF10413 Amino terminal of the G-protein receptor rhodopsin 0.0016 PF00122 E1-E2 ATPase 0.0014 PF00702 haloacid dehalogenase-like hydrolase 0.0014 PF02214 K+ channel tetramerisation domain 0.0014 PF00191 Annexin 0.0014 PF00194 Eukaryotic-type carbonic anhydrase 0.0012 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 0.0012 PF01007 Inward rectifier potassium channel 0.0008 PF12497 Estrogen receptor beta 0.0008 PF00273 Serum albumin family 0.0008 PF07885 Ion channel 0.0008 PF00520 Ion transport protein 0.0007 PF00060 Ligand-gated ion channel 0.0006 PF02155 Glucocorticoid receptor 0.0006 PF08403 Amino acid permease N-terminal 0.0005 PF01094 Receptor family ligand binding region 0.0005 PF02159 Oestrogen receptor 0.0003 PF02008 CXXC zinc finger domain 0.0003 PF00418 Tau and MAP protein, tubulin-binding repeat 0.0003 PF01426 BAH domain 0.0003 PF08377 MAP2/Tau projection domain 0.0003 PF06464 DMAP1-binding Domain 0.0003 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0003 PF00079 Serpin (serine protease inhibitor), 0.0002 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0002 PF00145 C-5 cytosine-specific DNA methylase 0.0002 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0002 PF00324 Amino acid permease 0.0001 PF00102 Protein-tyrosine phosphatase 0.0001 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0001 PF00462 Glutaredoxin 0.0001 PF01735 Lysophospholipase catalytic domain 0.0001 PF00111 2Fe-2S iron-sulfur cluster binding domain 0.0001 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0001 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0001 PF00576 HIUase/Transthyretin family SUB637 C-N-C-N-C 0.0038 PF01122 Eukaryotic cobalamin-binding protein 0.0028 PF02310 B12 binding domain 0.0026 PF01642 Methylmalonyl-CoA mutase 0.0026 PF01923 Cobalamin adenosyltransferase 0.0026 PF03308 ArgK protein 0.0013 PF00809 Pterin binding enzyme 0.0013 PF02607 B12 binding domain 0.0013 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0012 PF00258 Flavodoxin 0.0012 PF00667 FAD binding domain 0.0012 PF00431 CUB domain 0.0011 PF00175 Oxidoreductase NAD-binding domain 0.0008 PF07645 Calcium-binding EGF domain 0.0006 PF02574 Homocysteine S-methyltransferase 0.0004 PF02223 Thymidylate kinase 0.0003 PF08240 Alcohol dehydrogenase GroES-like domain 0.0003 PF00106 short chain dehydrogenase 0.0003 PF00107 Zinc-binding dehydrogenase 0.0003 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0003 PF00478 IMP dehydrogenase / GMP reductase domain 0.0002 PF00171 Aldehyde dehydrogenase family 0.0002 PF00571 CBS domain 0.0002 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0002 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0002 PF01126 Heme oxygenase 0.0002 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0002 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0002 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0002 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0002 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0002 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0002 PF00248 Aldo/keto reductase family 0.0002 PF02267 ADP-ribosyl cyclase 0.0002 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0001 PF00970 Oxidoreductase FAD-binding domain 0.0001 PF02233 NAD(P), transhydrogenase beta subunit 0.0001 PF00390 Malic enzyme, N-terminal domain 0.0001 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0001 PF01268 Formate--tetrahydrofolate ligase 0.0001 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0001 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0001 PF01575 MaoC like domain 0.0001 PF00676 Dehydrogenase E1 component 0.0001 PF01230 HIT domain 0.0001 PF00378 Enoyl-CoA hydratase/isomerase family 0.0001 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0001 PF03770 Inositol polyphosphate kinase 0.0001 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.0001 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.0001 PF01652 Eukaryotic initiation factor 4E 0.0001 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0001 PF02525 Flavodoxin-like fold 0.0001 PF00069 Protein kinase domain 0.0001 PF05347 Complex 1 protein (LYR family), 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF00018 SH3 domain 0.0001 PF00017 SH2 domain 0.0001 PF00057 Low-density lipoprotein receptor domain class A 0.0001 PF00058 Low-density lipoprotein receptor repeat class B 0.0001 PF02779 Transketolase, pyrimidine binding domain 0.0001 PF01403 Sema domain 0.0001 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.0001 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0001 PF02036 SCP-2 sterol transfer family 0.0001 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.0001 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 0.0001 PF00348 Polyprenyl synthetase 0.0001 PF03949 Malic enzyme, NAD binding domain 0.0001 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0001 PF01467 Cytidylyltransferase 0.0001 PF01687 Riboflavin kinase 0.0001 PF01208 Uroporphyrinogen decarboxylase (URO-D), 0.0001 PF01370 NAD dependent epimerase/dehydratase family 0.0001 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.0001 PF00186 Dihydrofolate reductase 0.0001 PF01833 IPT/TIG domain 0.0001 PF01437 Plexin repeat 0.0001 PF00070 Pyridine nucleotide-disulphide oxidoreductase SUB259 >= 2 hetero-aromatic rings 0.0017 PF01122 Eukaryotic cobalamin-binding protein 0.0013 PF02310 B12 binding domain 0.0012 PF01642 Methylmalonyl-CoA mutase 0.0012 PF01923 Cobalamin adenosyltransferase 0.0012 PF03308 ArgK protein 0.0006 PF02965 Vitamin B12 dependent methionine synthase, activation domain 0.0006 PF00809 Pterin binding enzyme 0.0006 PF02607 B12 binding domain 0.0006 PF00431 CUB domain 0.0005 PF00175 Oxidoreductase NAD-binding domain 0.0005 PF00667 FAD binding domain 0.0005 PF00258 Flavodoxin 0.0004 PF07645 Calcium-binding EGF domain 0.0003 PF02574 Homocysteine S-methyltransferase 0.0002 PF02223 Thymidylate kinase 0.0001 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0001 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0001 PF01652 Eukaryotic initiation factor 4E 0.0001 PF00571 CBS domain 0.0001 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.0001 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0001 PF02233 NAD(P), transhydrogenase beta subunit 0.0001 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0001 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0001 PF02267 ADP-ribosyl cyclase 0.0001 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0001 PF01467 Cytidylyltransferase 0.0001 PF00106 short chain dehydrogenase 0.0001 PF00107 Zinc-binding dehydrogenase 0.0001 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0001 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0001 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0001 PF08240 Alcohol dehydrogenase GroES-like domain 0.0001 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0001 PF00171 Aldehyde dehydrogenase family 0.0001 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.0001 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0001 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0001 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.0001 PF01126 Heme oxygenase 0.0001 PF00478 IMP dehydrogenase / GMP reductase domain 0.0001 PF00970 Oxidoreductase FAD-binding domain 0.0001 PF00248 Aldo/keto reductase family SUB438 C(-C)(-N)(=C) 0.0006 PF00204 DNA gyrase B 0.0006 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0006 PF08070 DTHCT (NUC029), region 0.0004 PF00186 Dihydrofolate reductase 0.0003 PF00001 7 transmembrane receptor (rhodopsin family), 0.0003 PF01048 Phosphorylase superfamily 0.0003 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0003 PF00069 Protein kinase domain 0.0002 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0002 PF00478 IMP dehydrogenase / GMP reductase domain 0.0001 PF02223 Thymidylate kinase 0.0001 PF00962 Adenosine/AMP deaminase 0.0001 PF00017 SH2 domain 0.0001 PF00018 SH3 domain 0.0001 PF08240 Alcohol dehydrogenase GroES-like domain 0.0001 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0001 PF08919 F-actin binding 0.0001 PF00107 Zinc-binding dehydrogenase 0.0001 PF00106 short chain dehydrogenase 0.0001 PF01590 GAF domain 0.0001 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0001 PF00571 CBS domain 0.0001 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0001 PF09040 Gastric H+/K+-ATPase, N terminal domain