1 2.1468 SUB158 >= 3 any ring size 5 1 2.1468 PF00106 short chain dehydrogenase 2 2.1118 SUB414 S(~C)(~H) 2 2.1118 PF00255 Glutathione peroxidase 3 1.9413 SUB158 >= 3 any ring size 5 3 1.9413 PF01126 Heme oxygenase 4 1.8035 SUB686 O=C-C-C-C-N 4 1.8035 PF01094 Receptor family ligand binding region 5 1.7707 SUB687 O=C-C-C-C-O 5 1.7707 PF03171 2OG-Fe(II), oxygenase superfamily 6 1.7514 SUB348 C(~C)(~H)(~O)(~O) 6 1.7514 PF03414 Glycosyltransferase family 6 7 1.6343 SUB387 C(:C)(:C)(:N) 7 1.6343 PF00042 Globin 8 1.6299 SUB409 O(~H)(~S) 8 1.6299 PF00167 Fibroblast growth factor 9 1.5807 SUB32 >= 2 P 9 1.5807 PF00348 Polyprenyl synthetase 10 1.5797 SUB567 O-C-C-N 10 1.5797 PF00464 Serine hydroxymethyltransferase 11 1.5105 SUB309 O-H 11 1.5105 PF00102 Protein-tyrosine phosphatase 12 1.5065 SUB433 C(-C)(-C)(=O) 12 1.5065 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 13 1.5033 SUB449 C(-H)(=O) 13 1.5033 PF00107 Zinc-binding dehydrogenase 14 1.4956 SUB695 O=C-C-C-C-C=O 14 1.4956 PF00551 Formyl transferase 15 1.4784 SUB433 C(-C)(-C)(=O) 15 1.4784 PF07884 Vitamin K epoxide reductase family 16 1.4255 SUB706 O=C-C-C-C-C(O)-C 16 1.4255 PF00079 Serpin (serine protease inhibitor), 17 1.4095 SUB484 N-S-C:C 17 1.4095 PF00324 Amino acid permease 18 1.4062 SUB13 >= 16 C 18 1.4062 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 19 1.4054 SUB360 C(~C)(:N)(:N) 19 1.4054 PF00106 short chain dehydrogenase 20 1.3993 SUB799 CC1CC(O)CCC1 20 1.3993 PF00168 C2 domain 21 1.3972 SUB4 >= 32 H 21 1.3972 PF00625 Guanylate kinase 22 1.3830 SUB567 O-C-C-N 22 1.3830 PF00155 Aminotransferase class I and II 23 1.3827 SUB302 N-O 23 1.3827 PF00850 Histone deacetylase domain 24 1.3778 SUB714 Cc1ccc(C)cc1 24 1.3778 PF00017 SH2 domain 25 1.3738 SUB217 >= 1 saturated or aromatic heteroatom-containing ring size 7 25 1.3738 PF00069 Protein kinase domain 26 1.3455 SUB38 >= 1 Cl 26 1.3455 PF08403 Amino acid permease N-terminal 27 1.3436 SUB158 >= 3 any ring size 5 27 1.3436 PF00067 Cytochrome P450 28 1.3095 SUB253 >= 1 unsaturated non-aromatic carbon-only ring size 10 28 1.3095 PF00191 Annexin 29 1.2755 SUB603 O=C-C-N-C 29 1.2755 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 30 1.2712 SUB498 O-C:C:N 30 1.2712 PF00266 Aminotransferase class-V 31 1.2692 SUB694 O=C-C-C-C-C-O 31 1.2692 PF00074 Pancreatic ribonuclease 32 1.2638 SUB336 C(~C)(~C)(~C)(~H) 32 1.2638 PF01007 Inward rectifier potassium channel 33 1.2614 SUB364 C(~F)(~F) 33 1.2614 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 34 1.2513 SUB840 CC1CC(C)CC1 34 1.2513 PF00191 Annexin 35 1.2502 SUB656 O-C-C-C:C 35 1.2502 PF00497 Bacterial extracellular solute-binding proteins, family 3 36 1.2353 SUB364 C(~F)(~F) 36 1.2353 PF00146 NADH dehydrogenase 37 1.2310 SUB306 N-S 37 1.2310 PF00194 Eukaryotic-type carbonic anhydrase 38 1.2168 SUB489 N-C=N-[#1] 38 1.2168 PF00089 Trypsin 39 1.2104 SUB537 O=C-C-N 39 1.2104 PF00375 Sodium:dicarboxylate symporter family 40 1.1965 SUB360 C(~C)(:N)(:N) 40 1.1965 PF00017 SH2 domain 41 1.1703 SUB336 C(~C)(~C)(~C)(~H) 41 1.1703 PF00133 tRNA synthetases class I (I, L, M and V), 42 1.1632 SUB686 O=C-C-C-C-N 42 1.1632 PF00282 Pyridoxal-dependent decarboxylase conserved domain 43 1.1558 SUB498 O-C:C:N 43 1.1558 PF00155 Aminotransferase class I and II 44 1.1505 SUB657 C-C-N-C-C 44 1.1505 PF07562 Nine Cysteines Domain of family 3 GPCR 45 1.1340 SUB615 C-C-O-C-C 45 1.1340 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 46 1.1295 SUB32 >= 2 P 46 1.1295 PF01370 NAD dependent epimerase/dehydratase family 47 1.1287 SUB567 O-C-C-N 47 1.1287 PF00266 Aminotransferase class-V 48 1.1271 SUB407 O(~C)(~H) 48 1.1271 PF01063 Aminotransferase class IV 49 1.1143 SUB389 C(:C)(:N)(:N) 49 1.1143 PF00106 short chain dehydrogenase 50 1.1100 SUB242 >= 1 any ring size 9 50 1.1100 PF01048 Phosphorylase superfamily 51 1.1078 SUB567 O-C-C-N 51 1.1078 PF00282 Pyridoxal-dependent decarboxylase conserved domain 52 1.1053 SUB172 >= 5 any ring size 5 52 1.1053 PF07645 Calcium-binding EGF domain 53 1.0969 SUB686 O=C-C-C-C-N 53 1.0969 PF02798 Glutathione S-transferase, N-terminal domain 54 1.0949 SUB841 CC1CC(O)CC1 54 1.0949 PF00001 7 transmembrane receptor (rhodopsin family), 55 1.0837 SUB4 >= 32 H 55 1.0837 PF08725 Integrin beta cytoplasmic domain 56 1.0798 SUB337 C(~C)(~C)(~C)(~N) 56 1.0798 PF00497 Bacterial extracellular solute-binding proteins, family 3 57 1.0768 SUB537 O=C-C-N 57 1.0768 PF01490 Transmembrane amino acid transporter protein 58 1.0699 SUB32 >= 2 P 58 1.0699 PF00248 Aldo/keto reductase family 59 1.0618 SUB537 O=C-C-N 59 1.0618 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 60 1.0586 SUB640 O-C-C-C-O 60 1.0586 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 61 1.0581 SUB193 >= 3 any ring size 6 61 1.0581 PF09396 Thrombin light chain 62 1.0516 SUB249 >= 1 any ring size 10 62 1.0516 PF03493 Calcium-activated BK potassium channel alpha subunit 63 1.0339 SUB414 S(~C)(~H) 63 1.0339 PF01124 MAPEG family 64 1.0302 SUB633 C-C-O-C:C 64 1.0302 PF01023 S-100/ICaBP type calcium binding domain 65 1.0268 SUB408 O(~C)(~P) 65 1.0268 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 66 1.0195 SUB38 >= 1 Cl 66 1.0195 PF00324 Amino acid permease 67 1.0116 SUB31 >= 1 P 67 1.0116 PF00069 Protein kinase domain 68 1.0087 SUB346 C(~C)(~H)(~N) 68 1.0087 PF02159 Oestrogen receptor 69 0.9925 SUB656 O-C-C-C:C 69 0.9925 PF00576 HIUase/Transthyretin family 70 0.9883 SUB703 O-C-C-C-C-C-N-C 70 0.9883 PF01401 Angiotensin-converting enzyme 71 0.9849 SUB686 O=C-C-C-C-N 71 0.9849 PF00068 Phospholipase A2 72 0.9721 SUB503 N-C=C-[#1] 72 0.9721 PF00069 Protein kinase domain 73 0.9712 SUB695 O=C-C-C-C-C=O 73 0.9712 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 74 0.9629 SUB398 N(~C)(:C)(:C) 74 0.9629 PF00071 Ras family 75 0.9546 SUB683 O-C-C-C-C-N 75 0.9546 PF00225 Kinesin motor domain 76 0.9526 SUB598 O=C-C-C:C 76 0.9526 PF06512 Sodium ion transport-associated 77 0.9491 SUB688 O=C-C-C-C=O 77 0.9491 PF00549 CoA-ligase 78 0.9442 SUB687 O=C-C-C-C-O 78 0.9442 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 79 0.9436 SUB618 C-C-C-O-[#1] 79 0.9436 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 80 0.9419 SUB673 O=C-C=C-[#1] 80 0.9419 PF00171 Aldehyde dehydrogenase family 81 0.9332 SUB694 O=C-C-C-C-C-O 81 0.9332 PF02798 Glutathione S-transferase, N-terminal domain 82 0.9327 SUB132 >= 1 saturated or aromatic nitrogen-containing ring size 4 82 0.9327 PF00854 POT family 83 0.9287 SUB242 >= 1 any ring size 9 83 0.9287 PF00478 IMP dehydrogenase / GMP reductase domain 84 0.9284 SUB537 O=C-C-N 84 0.9284 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 85 0.9219 SUB778 CC1CCC(O)CC1 85 0.9219 PF12497 Estrogen receptor beta 86 0.9204 SUB757 Cc1c(O)cccc1 86 0.9204 PF00001 7 transmembrane receptor (rhodopsin family), 87 0.9160 SUB140 >= 2 saturated or aromatic heteroatom-containing ring size 4 87 0.9160 PF00069 Protein kinase domain 88 0.9040 SUB572 [#1]-C-O-[#1] 88 0.9040 PF01607 Chitin binding Peritrophin-A domain 89 0.9040 SUB336 C(~C)(~C)(~C)(~H) 89 0.9040 PF00005 ABC transporter 90 0.9029 SUB686 O=C-C-C-C-N 90 0.9029 PF00464 Serine hydroxymethyltransferase 91 0.8984 SUB398 N(~C)(:C)(:C) 91 0.8984 PF00067 Cytochrome P450 92 0.8955 SUB622 N-C:C:C:N 92 0.8955 PF08240 Alcohol dehydrogenase GroES-like domain 93 0.8923 SUB17 >= 4 N 93 0.8923 PF00186 Dihydrofolate reductase 94 0.8863 SUB207 >= 5 any ring size 6 94 0.8863 PF02932 Neurotransmitter-gated ion-channel transmembrane region 95 0.8818 SUB379 C(~N)(:C)(:N) 95 0.8818 PF00962 Adenosine/AMP deaminase 96 0.8781 SUB207 >= 5 any ring size 6 96 0.8781 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 97 0.8767 SUB158 >= 3 any ring size 5 97 0.8767 PF00056 lactate/malate dehydrogenase, NAD binding domain 98 0.8713 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 98 0.8713 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 99 0.8678 SUB31 >= 1 P 99 0.8678 PF03770 Inositol polyphosphate kinase 100 0.8619 SUB441 C(-C)(-O)(=O) 100 0.8619 PF01401 Angiotensin-converting enzyme 101 0.8594 SUB567 O-C-C-N 101 0.8594 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 102 0.8589 SUB448 C(-H)(=N) 102 0.8589 PF02267 ADP-ribosyl cyclase 103 0.8582 SUB647 O=C-N-C-[#1] 103 0.8582 PF01401 Angiotensin-converting enzyme 104 0.8566 SUB588 N-C:C-O-[#1] 104 0.8566 PF00266 Aminotransferase class-V 105 0.8538 SUB410 O(:C)(:C) 105 0.8538 PF00001 7 transmembrane receptor (rhodopsin family), 106 0.8533 SUB379 C(~N)(:C)(:N) 106 0.8533 PF00858 Amiloride-sensitive sodium channel 107 0.8528 SUB447 C(-H)(=C) 107 0.8528 PF03098 Animal haem peroxidase 108 0.8525 SUB625 O=C-C:C-N 108 0.8525 PF00071 Ras family 109 0.8417 SUB567 O-C-C-N 109 0.8417 PF00153 Mitochondrial carrier protein 110 0.8379 SUB579 C-C:C-C:C 110 0.8379 PF00209 Sodium:neurotransmitter symporter family 111 0.8352 SUB696 O=C-C-C-C-C-N 111 0.8352 PF00026 Eukaryotic aspartyl protease 112 0.8269 SUB228 >= 1 any ring size 8 112 0.8269 PF02932 Neurotransmitter-gated ion-channel transmembrane region 113 0.8254 SUB588 N-C:C-O-[#1] 113 0.8254 PF00155 Aminotransferase class I and II 114 0.8242 SUB703 O-C-C-C-C-C-N-C 114 0.8242 PF00233 3"5"-cyclic nucleotide phosphodiesterase 115 0.8226 SUB407 O(~C)(~H) 115 0.8226 PF00576 HIUase/Transthyretin family 116 0.8091 SUB14 >= 32 C 116 0.8091 PF00149 Calcineurin-like phosphoesterase 117 0.8086 SUB18 >= 8 N 117 0.8086 PF07992 Pyridine nucleotide-disulphide oxidoreductase 118 0.8084 SUB339 C(~C)(~C)(~H)(~N) 118 0.8084 PF00128 Alpha amylase, catalytic domain 119 0.8007 SUB396 N(~C)(~O) 119 0.8007 PF00850 Histone deacetylase domain 120 0.8003 SUB757 Cc1c(O)cccc1 120 0.8003 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 121 0.7997 SUB529 [#1]-N-C-[#1] 121 0.7997 PF00117 Glutamine amidotransferase class-I 122 0.7973 SUB653 O-C:C:C-N 122 0.7973 PF00001 7 transmembrane receptor (rhodopsin family), 123 0.7953 SUB682 O-C-C-C-C-O 123 0.7953 PF01532 Glycosyl hydrolase family 47 124 0.7924 SUB424 N=O 124 0.7924 PF00211 Adenylate and Guanylate cyclase catalytic domain 125 0.7822 SUB375 C(~H)(~H)(~H) 125 0.7822 PF00305 Lipoxygenase 126 0.7768 SUB799 CC1CC(O)CCC1 126 0.7768 PF00520 Ion transport protein 127 0.7753 SUB441 C(-C)(-O)(=O) 127 0.7753 PF00324 Amino acid permease 128 0.7714 SUB715 Cc1ccc(O)cc1 128 0.7714 PF00105 Zinc finger, C4 type (two domains), 129 0.7710 SUB365 C(~F)(:C) 129 0.7710 PF00069 Protein kinase domain 130 0.7702 SUB643 O-C-C-C=O 130 0.7702 PF00291 Pyridoxal-phosphate dependent enzyme 131 0.7689 SUB602 N-C:C:C-N 131 0.7689 PF00069 Protein kinase domain 132 0.7664 SUB712 C-C(C)(C)-C-C 132 0.7664 PF00106 short chain dehydrogenase 133 0.7659 SUB674 O=C-C=C-N 133 0.7659 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 134 0.7655 SUB825 OC1C(O)CCCC1 134 0.7655 PF00091 Tubulin/FtsZ family, GTPase domain 135 0.7641 SUB536 O=C-C-C 135 0.7641 PF07690 Major Facilitator Superfamily 136 0.7637 SUB214 >= 1 any ring size 7 136 0.7637 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 137 0.7628 SUB375 C(~H)(~H)(~H) 137 0.7628 PF00135 Carboxylesterase 138 0.7580 SUB606 O=C-C-O-C 138 0.7580 PF00001 7 transmembrane receptor (rhodopsin family), 139 0.7557 SUB252 >= 1 saturated or aromatic heteroatom-containing ring size 10 139 0.7557 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 140 0.7554 SUB529 [#1]-N-C-[#1] 140 0.7554 PF00709 Adenylosuccinate synthetase 141 0.7535 SUB494 O=C-C:C 141 0.7535 PF00017 SH2 domain 142 0.7510 SUB252 >= 1 saturated or aromatic heteroatom-containing ring size 10 142 0.7510 PF00233 3"5"-cyclic nucleotide phosphodiesterase 143 0.7496 SUB486 N:C:C:N 143 0.7496 PF00858 Amiloride-sensitive sodium channel 144 0.7478 SUB208 >= 5 saturated or aromatic carbon-only ring size 6 144 0.7478 PF00089 Trypsin 145 0.7464 SUB712 C-C(C)(C)-C-C 145 0.7464 PF03953 Tubulin C-terminal domain 146 0.7455 SUB716 Cc1ccc(S)cc1 146 0.7455 PF00005 ABC transporter 147 0.7430 SUB715 Cc1ccc(O)cc1 147 0.7430 PF00104 Ligand-binding domain of nuclear hormone receptor 148 0.7402 SUB674 O=C-C=C-N 148 0.7402 PF00303 Thymidylate synthase 149 0.7384 SUB14 >= 32 C 149 0.7384 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 150 0.7340 SUB718 Cc1ccc(Cl)cc1 150 0.7340 PF01094 Receptor family ligand binding region 151 0.7315 SUB441 C(-C)(-O)(=O) 151 0.7315 PF00354 Pentaxin family 152 0.7291 SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 152 0.7291 PF00501 AMP-binding enzyme 153 0.7258 SUB683 O-C-C-C-C-N 153 0.7258 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 154 0.7257 SUB602 N-C:C:C-N 154 0.7257 PF08240 Alcohol dehydrogenase GroES-like domain 155 0.7249 SUB712 C-C(C)(C)-C-C 155 0.7249 PF00104 Ligand-binding domain of nuclear hormone receptor 156 0.7234 SUB288 C-F 156 0.7234 PF00520 Ion transport protein 157 0.7223 SUB674 O=C-C=C-N 157 0.7223 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 158 0.7191 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 158 0.7191 PF00041 Fibronectin type III domain 159 0.7146 SUB259 >= 2 hetero-aromatic rings 159 0.7146 PF00017 SH2 domain 160 0.7139 SUB253 >= 1 unsaturated non-aromatic carbon-only ring size 10 160 0.7139 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 161 0.7135 SUB706 O=C-C-C-C-C(O)-C 161 0.7135 PF00229 TNF(Tumour Necrosis Factor), family 162 0.7130 SUB389 C(:C)(:N)(:N) 162 0.7130 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 163 0.7124 SUB708 O=C-C-C-C-C(N)-C 163 0.7124 PF02310 B12 binding domain 164 0.7121 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 164 0.7121 PF02159 Oestrogen receptor 165 0.7108 SUB381 C(~O)(~O) 165 0.7108 PF00405 Transferrin 166 0.7103 SUB433 C(-C)(-C)(=O) 166 0.7103 PF07690 Major Facilitator Superfamily 167 0.7099 SUB364 C(~F)(~F) 167 0.7099 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 168 0.7047 SUB379 C(~N)(:C)(:N) 168 0.7047 PF00156 Phosphoribosyl transferase domain 169 0.7043 SUB346 C(~C)(~H)(~N) 169 0.7043 PF00209 Sodium:neurotransmitter symporter family 170 0.7040 SUB693 O=C-C-C-C-C-C 170 0.7040 PF00089 Trypsin 171 0.6969 SUB262 >= 4 aromatic rings 171 0.6969 PF00089 Trypsin 172 0.6960 SUB613 N-C-O-C-C 172 0.6960 PF02223 Thymidylate kinase 173 0.6959 SUB720 Oc1ccc(O)cc1 173 0.6959 PF00105 Zinc finger, C4 type (two domains), 174 0.6931 SUB5 >= 1 Li 174 0.6931 PF00459 Inositol monophosphatase family 175 0.6926 SUB348 C(~C)(~H)(~O)(~O) 175 0.6926 PF00143 Interferon alpha/beta domain 176 0.6921 SUB336 C(~C)(~C)(~C)(~H) 176 0.6921 PF00051 Kringle domain 177 0.6915 SUB760 Cc1c(Cl)cccc1 177 0.6915 PF00069 Protein kinase domain 178 0.6914 SUB459 S(-O)(=O) 178 0.6914 PF00194 Eukaryotic-type carbonic anhydrase 179 0.6907 SUB392 N(~C)(~C)(~C) 179 0.6907 PF08674 Acetylcholinesterase tetramerisation domain 180 0.6866 SUB821 CC1C(S)CCCC1 180 0.6866 PF00001 7 transmembrane receptor (rhodopsin family), 181 0.6859 SUB25 >= 2 F 181 0.6859 PF00690 Cation transporter/ATPase, N-terminus 182 0.6854 SUB345 C(~C)(~H) 182 0.6854 PF00273 Serum albumin family 183 0.6829 SUB703 O-C-C-C-C-C-N-C 183 0.6829 PF08527 Protein-arginine deiminase (PAD), middle domain 184 0.6828 SUB407 O(~C)(~H) 184 0.6828 PF02898 Nitric oxide synthase, oxygenase domain 185 0.6828 SUB646 O=C-N-C-C 185 0.6828 PF02166 Androgen receptor 186 0.6826 SUB554 O=C-C=C 186 0.6826 PF00464 Serine hydroxymethyltransferase 187 0.6777 SUB369 C(~H)(~S) 187 0.6777 PF00233 3"5"-cyclic nucleotide phosphodiesterase 188 0.6717 SUB309 O-H 188 0.6717 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 189 0.6712 SUB200 >= 4 any ring size 6 189 0.6712 PF00089 Trypsin 190 0.6673 SUB691 O-C-C-C-C-C-O 190 0.6673 PF02806 Alpha amylase, C-terminal all-beta domain 191 0.6657 SUB691 O-C-C-C-C-C-O 191 0.6657 PF01094 Receptor family ligand binding region 192 0.6653 SUB421 C=O 192 0.6653 PF00107 Zinc-binding dehydrogenase 193 0.6645 SUB347 C(~C)(~H)(~O) 193 0.6645 PF00343 Carbohydrate phosphorylase 194 0.6639 SUB541 C-N-C-[#1] 194 0.6639 PF00755 Choline/Carnitine o-acyltransferase 195 0.6616 SUB687 O=C-C-C-C-O 195 0.6616 PF00939 Sodium:sulfate symporter transmembrane region 196 0.6587 SUB440 C(-C)(-N)(=O) 196 0.6587 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 197 0.6544 SUB577 N=C-C:C-[#1] 197 0.6544 PF03073 TspO/MBR family 198 0.6464 SUB568 O-C-C-O 198 0.6464 PF00017 SH2 domain 199 0.6448 SUB664 O-C-C-O-[#1] 199 0.6448 PF00728 Glycosyl hydrolase family 20, catalytic domain 200 0.6438 SUB631 O-C:C-O-C 200 0.6438 PF07690 Major Facilitator Superfamily 201 0.6426 SUB3 >= 16 H 201 0.6426 PF00001 7 transmembrane receptor (rhodopsin family), 202 0.6408 SUB422 C=S 202 0.6408 PF07645 Calcium-binding EGF domain 203 0.6392 SUB664 O-C-C-O-[#1] 203 0.6392 PF01370 NAD dependent epimerase/dehydratase family 204 0.6389 SUB537 O=C-C-N 204 0.6389 PF00579 tRNA synthetases class I (W and Y), 205 0.6388 SUB547 N-C:C-[#1] 205 0.6388 PF07885 Ion channel 206 0.6365 SUB23 >= 16 O 206 0.6365 PF02793 Hormone receptor domain 207 0.6360 SUB631 O-C:C-O-C 207 0.6360 PF00643 B-box zinc finger 208 0.6350 SUB419 C=N 208 0.6350 PF00051 Kringle domain 209 0.6334 SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 209 0.6334 PF03807 NADP oxidoreductase coenzyme F420-dependent 210 0.6318 SUB277 B-O 210 0.6318 PF00227 Proteasome subunit 211 0.6310 SUB25 >= 2 F 211 0.6310 PF00689 Cation transporting ATPase, C-terminus 212 0.6306 SUB406 O(~C)(~C) 212 0.6306 PF00059 Lectin C-type domain 213 0.6299 SUB594 N-C-C-C-N 213 0.6299 PF00583 Acetyltransferase (GNAT), family 214 0.6285 SUB545 O-C:C-O 214 0.6285 PF00001 7 transmembrane receptor (rhodopsin family), 215 0.6267 SUB862 CC1C(O)CCC1 215 0.6267 PF00001 7 transmembrane receptor (rhodopsin family), 216 0.6256 SUB284 C-H 216 0.6256 PF00194 Eukaryotic-type carbonic anhydrase 217 0.6231 SUB381 C(~O)(~O) 217 0.6231 PF00058 Low-density lipoprotein receptor repeat class B 218 0.6227 SUB484 N-S-C:C 218 0.6227 PF08403 Amino acid permease N-terminal 219 0.6219 SUB14 >= 32 C 219 0.6219 PF00493 MCM2/3/5 family 220 0.6191 SUB458 S(-C)(=O) 220 0.6191 PF01007 Inward rectifier potassium channel 221 0.6181 SUB567 O-C-C-N 221 0.6181 PF00248 Aldo/keto reductase family 222 0.6153 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 222 0.6153 PF01039 Carboxyl transferase domain 223 0.6131 SUB16 >= 2 N 223 0.6131 PF00194 Eukaryotic-type carbonic anhydrase 224 0.6131 SUB172 >= 5 any ring size 5 224 0.6131 PF01122 Eukaryotic cobalamin-binding protein 225 0.6114 SUB695 O=C-C-C-C-C=O 225 0.6114 PF00023 Ankyrin repeat 226 0.6112 SUB186 >= 2 any ring size 6 226 0.6112 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 227 0.6095 SUB335 C(~C)(~C)(~C)(~C) 227 0.6095 PF00106 short chain dehydrogenase 228 0.6075 SUB432 C(-C)(-C)(=N) 228 0.6075 PF00343 Carbohydrate phosphorylase 229 0.6051 SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 229 0.6051 PF00106 short chain dehydrogenase 230 0.6041 SUB407 O(~C)(~H) 230 0.6041 PF00557 Metallopeptidase family M24 231 0.6022 SUB577 N=C-C:C-[#1] 231 0.6022 PF00089 Trypsin 232 0.6007 SUB686 O=C-C-C-C-N 232 0.6007 PF00060 Ligand-gated ion channel 233 0.6004 SUB3 >= 16 H 233 0.6004 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 234 0.5981 SUB250 >= 1 saturated or aromatic carbon-only ring size 10 234 0.5981 PF08491 Squalene epoxidase 235 0.5976 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 235 0.5976 PF00676 Dehydrogenase E1 component 236 0.5946 SUB717 Cc1ccc(N)cc1 236 0.5946 PF02310 B12 binding domain 237 0.5940 SUB595 C-O-C-C=C 237 0.5940 PF00091 Tubulin/FtsZ family, GTPase domain 238 0.5932 SUB695 O=C-C-C-C-C=O 238 0.5932 PF00255 Glutathione peroxidase 239 0.5931 SUB647 O=C-N-C-[#1] 239 0.5931 PF07686 Immunoglobulin V-set domain 240 0.5931 SUB673 O=C-C=C-[#1] 240 0.5931 PF00531 Death domain 241 0.5926 SUB668 C=C-C-O-[#1] 241 0.5926 PF00171 Aldehyde dehydrogenase family 242 0.5921 SUB286 C-N 242 0.5921 PF00497 Bacterial extracellular solute-binding proteins, family 3 243 0.5914 SUB147 >= 1 saturated or aromatic heteroatom-containing ring size 5 243 0.5914 PF00478 IMP dehydrogenase / GMP reductase domain 244 0.5895 SUB660 O-C-C-N-C 244 0.5895 PF01467 Cytidylyltransferase 245 0.5891 SUB407 O(~C)(~H) 245 0.5891 PF01180 Dihydroorotate dehydrogenase 246 0.5858 SUB414 S(~C)(~H) 246 0.5858 PF00656 Caspase domain 247 0.5843 SUB489 N-C=N-[#1] 247 0.5843 PF02807 ATP:guanido phosphotransferase, N-terminal domain 248 0.5840 SUB381 C(~O)(~O) 248 0.5840 PF07654 Immunoglobulin C1-set domain 249 0.5820 SUB686 O=C-C-C-C-N 249 0.5820 PF00043 Glutathione S-transferase, C-terminal domain 250 0.5812 SUB17 >= 4 N 250 0.5812 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 251 0.5811 SUB536 O=C-C-C 251 0.5811 PF00202 Aminotransferase class-III 252 0.5807 SUB700 O-C-C-C-C-C(C)-C 252 0.5807 PF01401 Angiotensin-converting enzyme 253 0.5803 SUB339 C(~C)(~C)(~H)(~N) 253 0.5803 PF07690 Major Facilitator Superfamily 254 0.5782 SUB158 >= 3 any ring size 5 254 0.5782 PF00180 Isocitrate/isopropylmalate dehydrogenase 255 0.5778 SUB392 N(~C)(~C)(~C) 255 0.5778 PF00001 7 transmembrane receptor (rhodopsin family), 256 0.5771 SUB602 N-C:C:C-N 256 0.5771 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 257 0.5760 SUB360 C(~C)(:N)(:N) 257 0.5760 PF00074 Pancreatic ribonuclease 258 0.5755 SUB682 O-C-C-C-C-O 258 0.5755 PF00501 AMP-binding enzyme 259 0.5749 SUB668 C=C-C-O-[#1] 259 0.5749 PF00102 Protein-tyrosine phosphatase 260 0.5740 SUB367 C(~H)(~O) 260 0.5740 PF02214 K+ channel tetramerisation domain 261 0.5737 SUB306 N-S 261 0.5737 PF01007 Inward rectifier potassium channel 262 0.5719 SUB3 >= 16 H 262 0.5719 PF00005 ABC transporter 263 0.5710 SUB591 C-C:C-O-[#1] 263 0.5710 PF00069 Protein kinase domain 264 0.5694 SUB260 >= 3 aromatic rings 264 0.5694 PF00989 PAS fold 265 0.5658 SUB522 C:N-C-[#1] 265 0.5658 PF00105 Zinc finger, C4 type (two domains), 266 0.5652 SUB23 >= 16 O 266 0.5652 PF00002 7 transmembrane receptor (Secretin family), 267 0.5642 SUB647 O=C-N-C-[#1] 267 0.5642 PF01431 Peptidase family M13 268 0.5621 SUB417 C=C 268 0.5621 PF03098 Animal haem peroxidase 269 0.5618 SUB682 O-C-C-C-C-O 269 0.5618 PF00349 Hexokinase 270 0.5604 SUB549 O-C-C:C 270 0.5604 PF00989 PAS fold 271 0.5598 SUB216 >= 1 saturated or aromatic nitrogen-containing ring size 7 271 0.5598 PF00069 Protein kinase domain 272 0.5597 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 272 0.5597 PF00171 Aldehyde dehydrogenase family 273 0.5593 SUB624 O=C-C:C-C 273 0.5593 PF00343 Carbohydrate phosphorylase 274 0.5587 SUB715 Cc1ccc(O)cc1 274 0.5587 PF00017 SH2 domain 275 0.5585 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 275 0.5585 PF00069 Protein kinase domain 276 0.5583 SUB406 O(~C)(~C) 276 0.5583 PF07645 Calcium-binding EGF domain 277 0.5580 SUB343 C(~C)(~Cl) 277 0.5580 PF02254 TrkA-N domain 278 0.5561 SUB249 >= 1 any ring size 10 278 0.5561 PF08070 DTHCT (NUC029), region 279 0.5536 SUB348 C(~C)(~H)(~O)(~O) 279 0.5536 PF00337 Galactoside-binding lectin 280 0.5534 SUB672 O=C-C=C-C 280 0.5534 PF00069 Protein kinase domain 281 0.5525 SUB799 CC1CC(O)CCC1 281 0.5525 PF01735 Lysophospholipase catalytic domain 282 0.5482 SUB572 [#1]-C-O-[#1] 282 0.5482 PF00400 WD domain, G-beta repeat 283 0.5476 SUB415 S(~C)(~O) 283 0.5476 PF01007 Inward rectifier potassium channel 284 0.5470 SUB629 C-N-C-C:C 284 0.5470 PF02180 Bcl-2 homology region 4 285 0.5466 SUB369 C(~H)(~S) 285 0.5466 PF01770 Reduced folate carrier 286 0.5446 SUB756 Cc1c(C)cccc1 286 0.5446 PF07645 Calcium-binding EGF domain 287 0.5436 SUB631 O-C:C-O-C 287 0.5436 PF00233 3"5"-cyclic nucleotide phosphodiesterase 288 0.5428 SUB24 >= 1 F 288 0.5428 PF07686 Immunoglobulin V-set domain 289 0.5416 SUB20 >= 2 O 289 0.5416 PF03098 Animal haem peroxidase 290 0.5404 SUB459 S(-O)(=O) 290 0.5404 PF00089 Trypsin 291 0.5398 SUB664 O-C-C-O-[#1] 291 0.5398 PF02065 Melibiase 292 0.5383 SUB32 >= 2 P 292 0.5383 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 293 0.5376 SUB180 >= 1 saturated or aromatic carbon-only ring size 6 293 0.5376 PF02159 Oestrogen receptor 294 0.5371 SUB591 C-C:C-O-[#1] 294 0.5371 PF00282 Pyridoxal-dependent decarboxylase conserved domain 295 0.5362 SUB151 >= 2 any ring size 5 295 0.5362 PF00170 bZIP transcription factor 296 0.5335 SUB633 C-C-O-C:C 296 0.5335 PF00650 CRAL/TRIO domain 297 0.5323 SUB686 O=C-C-C-C-N 297 0.5323 PF00155 Aminotransferase class I and II 298 0.5320 SUB603 O=C-C-N-C 298 0.5320 PF00089 Trypsin 299 0.5286 SUB249 >= 1 any ring size 10 299 0.5286 PF00204 DNA gyrase B 300 0.5256 SUB15 >= 1 N 300 0.5256 PF00497 Bacterial extracellular solute-binding proteins, family 3 301 0.5256 SUB529 [#1]-N-C-[#1] 301 0.5256 PF00209 Sodium:neurotransmitter symporter family 302 0.5228 SUB567 O-C-C-N 302 0.5228 PF00764 Arginosuccinate synthase 303 0.5209 SUB444 C(-C)(=O) 303 0.5209 PF00202 Aminotransferase class-III 304 0.5191 SUB24 >= 1 F 304 0.5191 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 305 0.5187 SUB751 Nc1cc(Cl)ccc1 305 0.5187 PF00043 Glutathione S-transferase, C-terminal domain 306 0.5185 SUB762 Oc1c(O)cccc1 306 0.5185 PF00001 7 transmembrane receptor (rhodopsin family), 307 0.5173 SUB16 >= 2 N 307 0.5173 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 308 0.5161 SUB151 >= 2 any ring size 5 308 0.5161 PF00069 Protein kinase domain 309 0.5154 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 309 0.5154 PF00364 Biotin-requiring enzyme 310 0.5139 SUB738 Cc1cc(N)ccc1 310 0.5139 PF00105 Zinc finger, C4 type (two domains), 311 0.5118 SUB32 >= 2 P 311 0.5118 PF00153 Mitochondrial carrier protein 312 0.5115 SUB379 C(~N)(:C)(:N) 312 0.5115 PF00186 Dihydrofolate reductase 313 0.5114 SUB537 O=C-C-N 313 0.5114 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 314 0.5108 SUB17 >= 4 N 314 0.5108 PF01916 Deoxyhypusine synthase 315 0.5100 SUB407 O(~C)(~H) 315 0.5100 PF00079 Serpin (serine protease inhibitor), 316 0.5098 SUB407 O(~C)(~H) 316 0.5098 PF00303 Thymidylate synthase 317 0.5076 SUB516 N-N-C-C 317 0.5076 PF00664 ABC transporter transmembrane region 318 0.5060 SUB342 C(~C)(~C)(~O) 318 0.5060 PF02525 Flavodoxin-like fold 319 0.5032 SUB675 N-C-N-C:C 319 0.5032 PF00001 7 transmembrane receptor (rhodopsin family), 320 0.5010 SUB712 C-C(C)(C)-C-C 320 0.5010 PF00091 Tubulin/FtsZ family, GTPase domain 321 0.5005 SUB20 >= 2 O 321 0.5005 PF00821 Phosphoenolpyruvate carboxykinase 322 0.4999 SUB390 C(:N)(:N) 322 0.4999 PF00478 IMP dehydrogenase / GMP reductase domain 323 0.4983 SUB801 CC1CC(N)CCC1 323 0.4983 PF00001 7 transmembrane receptor (rhodopsin family), 324 0.4931 SUB261 >= 3 hetero-aromatic rings 324 0.4931 PF00017 SH2 domain 325 0.4917 SUB4 >= 32 H 325 0.4917 PF00650 CRAL/TRIO domain 326 0.4909 SUB574 O-C-C=C 326 0.4909 PF00822 PMP-22/EMP/MP20/Claudin family 327 0.4903 SUB7 >= 1 B 327 0.4903 PF00227 Proteasome subunit 328 0.4899 SUB288 C-F 328 0.4899 PF03477 ATP cone domain 329 0.4897 SUB759 Cc1c(N)cccc1 329 0.4897 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 330 0.4896 SUB520 N=C-N-C 330 0.4896 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 331 0.4896 SUB21 >= 4 O 331 0.4896 PF00822 PMP-22/EMP/MP20/Claudin family 332 0.4884 SUB682 O-C-C-C-C-O 332 0.4884 PF03360 Glycosyltransferase family 43 333 0.4877 SUB486 N:C:C:N 333 0.4877 PF00962 Adenosine/AMP deaminase 334 0.4864 SUB691 O-C-C-C-C-C-O 334 0.4864 PF00005 ABC transporter 335 0.4850 SUB13 >= 16 C 335 0.4850 PF00171 Aldehyde dehydrogenase family 336 0.4850 SUB517 [#1]-C=C-[#1] 336 0.4850 PF03098 Animal haem peroxidase 337 0.4803 SUB689 C-C-C-C-C-C-C 337 0.4803 PF01593 Flavin containing amine oxidoreductase 338 0.4784 SUB629 C-N-C-C:C 338 0.4784 PF00248 Aldo/keto reductase family 339 0.4771 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 339 0.4771 PF00211 Adenylate and Guanylate cyclase catalytic domain 340 0.4757 SUB193 >= 3 any ring size 6 340 0.4757 PF00001 7 transmembrane receptor (rhodopsin family), 341 0.4753 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 341 0.4753 PF00059 Lectin C-type domain 342 0.4720 SUB460 S(=O)(=O) 342 0.4720 PF00194 Eukaryotic-type carbonic anhydrase 343 0.4717 SUB533 S-C:C-[#1] 343 0.4717 PF00045 Hemopexin 344 0.4713 SUB348 C(~C)(~H)(~O)(~O) 344 0.4713 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 345 0.4701 SUB452 C(-N)(=O) 345 0.4701 PF01007 Inward rectifier potassium channel 346 0.4697 SUB367 C(~H)(~O) 346 0.4697 PF00084 Sushi domain (SCR repeat), 347 0.4696 SUB572 [#1]-C-O-[#1] 347 0.4696 PF00041 Fibronectin type III domain 348 0.4694 SUB622 N-C:C:C:N 348 0.4694 PF00069 Protein kinase domain 349 0.4686 SUB367 C(~H)(~O) 349 0.4686 PF00069 Protein kinase domain 350 0.4680 SUB4 >= 32 H 350 0.4680 PF00149 Calcineurin-like phosphoesterase 351 0.4665 SUB12 >= 8 C 351 0.4665 PF01593 Flavin containing amine oxidoreductase 352 0.4661 SUB186 >= 2 any ring size 6 352 0.4661 PF00067 Cytochrome P450 353 0.4657 SUB580 O=C-C-C-C 353 0.4657 PF03171 2OG-Fe(II), oxygenase superfamily 354 0.4655 SUB48 >= 2 I 354 0.4655 PF00105 Zinc finger, C4 type (two domains), 355 0.4625 SUB536 O=C-C-C 355 0.4625 PF00233 3"5"-cyclic nucleotide phosphodiesterase 356 0.4623 SUB666 N-C:C-C-C 356 0.4623 PF00520 Ion transport protein 357 0.4612 SUB651 O=C-N-C=O 357 0.4612 PF00520 Ion transport protein 358 0.4607 SUB529 [#1]-N-C-[#1] 358 0.4607 PF00324 Amino acid permease 359 0.4601 SUB460 S(=O)(=O) 359 0.4601 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 360 0.4586 SUB537 O=C-C-N 360 0.4586 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 361 0.4551 SUB357 C(~C)(:C)(:C) 361 0.4551 PF01593 Flavin containing amine oxidoreductase 362 0.4548 SUB572 [#1]-C-O-[#1] 362 0.4548 PF00303 Thymidylate synthase 363 0.4547 SUB708 O=C-C-C-C-C(N)-C 363 0.4547 PF07690 Major Facilitator Superfamily 364 0.4539 SUB426 P=O 364 0.4539 PF00017 SH2 domain 365 0.4523 SUB537 O=C-C-N 365 0.4523 PF01841 Transglutaminase-like superfamily 366 0.4492 SUB618 C-C-C-O-[#1] 366 0.4492 PF02574 Homocysteine S-methyltransferase 367 0.4491 SUB488 N-C=N-C 367 0.4491 PF01048 Phosphorylase superfamily 368 0.4483 SUB690 O-C-C-C-C-C-C 368 0.4483 PF08763 Voltage gated calcium channel IQ domain 369 0.4477 SUB453 C(-O)(=O) 369 0.4477 PF00324 Amino acid permease 370 0.4474 SUB529 [#1]-N-C-[#1] 370 0.4474 PF00051 Kringle domain 371 0.4470 SUB451 C(-N)(=N) 371 0.4470 PF00186 Dihydrofolate reductase 372 0.4465 SUB341 C(~C)(~C)(~N) 372 0.4465 PF06512 Sodium ion transport-associated 373 0.4456 SUB389 C(:C)(:N)(:N) 373 0.4456 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 374 0.4442 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 374 0.4442 PF00229 TNF(Tumour Necrosis Factor), family 375 0.4435 SUB667 C=C-C-O-C 375 0.4435 PF00091 Tubulin/FtsZ family, GTPase domain 376 0.4427 SUB259 >= 2 hetero-aromatic rings 376 0.4427 PF00005 ABC transporter 377 0.4416 SUB680 C-C-C-C-C-C 377 0.4416 PF08718 Glycolipid transfer protein (GLTP), 378 0.4405 SUB309 O-H 378 0.4405 PF00557 Metallopeptidase family M24 379 0.4397 SUB492 C-N:C-[#1] 379 0.4397 PF00571 CBS domain 380 0.4389 SUB622 N-C:C:C:N 380 0.4389 PF00175 Oxidoreductase NAD-binding domain 381 0.4369 SUB578 C:C-N-C:C 381 0.4369 PF00858 Amiloride-sensitive sodium channel 382 0.4364 SUB340 C(~C)(~C)(~H)(~O) 382 0.4364 PF00001 7 transmembrane receptor (rhodopsin family), 383 0.4360 SUB681 O-C-C-C-C-C 383 0.4360 PF00023 Ankyrin repeat 384 0.4358 SUB500 N-C:C:N 384 0.4358 PF00156 Phosphoribosyl transferase domain 385 0.4358 SUB441 C(-C)(-O)(=O) 385 0.4358 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 386 0.4350 SUB580 O=C-C-C-C 386 0.4350 PF00153 Mitochondrial carrier protein 387 0.4332 SUB618 C-C-C-O-[#1] 387 0.4332 PF00310 Glutamine amidotransferases class-II 388 0.4292 SUB663 O-C-C-O-C 388 0.4292 PF00454 Phosphatidylinositol 3- and 4-kinase 389 0.4289 SUB32 >= 2 P 389 0.4289 PF02770 Acyl-CoA dehydrogenase, middle domain 390 0.4287 SUB515 O-N-C-C 390 0.4287 PF01471 Putative peptidoglycan binding domain 391 0.4277 SUB712 C-C(C)(C)-C-C 391 0.4277 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 392 0.4270 SUB537 O=C-C-N 392 0.4270 PF00155 Aminotransferase class I and II 393 0.4269 SUB288 C-F 393 0.4269 PF01094 Receptor family ligand binding region 394 0.4265 SUB686 O=C-C-C-C-N 394 0.4265 PF00413 Matrixin 395 0.4263 SUB519 O=C-N-N 395 0.4263 PF00664 ABC transporter transmembrane region 396 0.4256 SUB421 C=O 396 0.4256 PF00202 Aminotransferase class-III 397 0.4252 SUB369 C(~H)(~S) 397 0.4252 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 398 0.4248 SUB258 >= 2 aromatic rings 398 0.4248 PF00520 Ion transport protein 399 0.4243 SUB686 O=C-C-C-C-N 399 0.4243 PF04961 Formiminotransferase-cyclodeaminase 400 0.4222 SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 400 0.4222 PF00069 Protein kinase domain 401 0.4219 SUB575 O-C-C:C-C 401 0.4219 PF00989 PAS fold 402 0.4186 SUB419 C=N 402 0.4186 PF00175 Oxidoreductase NAD-binding domain 403 0.4164 SUB253 >= 1 unsaturated non-aromatic carbon-only ring size 10 403 0.4164 PF00656 Caspase domain 404 0.4154 SUB20 >= 2 O 404 0.4154 PF00273 Serum albumin family 405 0.4137 SUB441 C(-C)(-O)(=O) 405 0.4137 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 406 0.4132 SUB499 O-C=C-C 406 0.4132 PF00069 Protein kinase domain 407 0.4129 SUB582 O=C-C-C-O 407 0.4129 PF00005 ABC transporter 408 0.4119 SUB500 N-C:C:N 408 0.4119 PF00962 Adenosine/AMP deaminase 409 0.4109 SUB407 O(~C)(~H) 409 0.4109 PF00390 Malic enzyme, N-terminal domain 410 0.4107 SUB578 C:C-N-C:C 410 0.4107 PF00343 Carbohydrate phosphorylase 411 0.4105 SUB22 >= 8 O 411 0.4105 PF07992 Pyridine nucleotide-disulphide oxidoreductase 412 0.4100 SUB572 [#1]-C-O-[#1] 412 0.4100 PF04515 Plasma-membrane choline transporter 413 0.4091 SUB505 N:C:N-C 413 0.4091 PF00005 ABC transporter 414 0.4090 SUB695 O=C-C-C-C-C=O 414 0.4090 PF04389 Peptidase family M28 415 0.4087 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 415 0.4087 PF00571 CBS domain 416 0.4086 SUB249 >= 1 any ring size 10 416 0.4086 PF02254 TrkA-N domain 417 0.4086 SUB366 C(~H)(~N) 417 0.4086 PF00209 Sodium:neurotransmitter symporter family 418 0.4085 SUB545 O-C:C-O 418 0.4085 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 419 0.4080 SUB200 >= 4 any ring size 6 419 0.4080 PF00069 Protein kinase domain 420 0.4072 SUB32 >= 2 P 420 0.4072 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 421 0.4061 SUB534 S-C:C-N 421 0.4061 PF00001 7 transmembrane receptor (rhodopsin family), 422 0.4060 SUB350 C(~C)(~H)(~S) 422 0.4060 PF02798 Glutathione S-transferase, N-terminal domain 423 0.4050 SUB682 O-C-C-C-C-O 423 0.4050 PF01230 HIT domain 424 0.4045 SUB460 S(=O)(=O) 424 0.4045 PF00520 Ion transport protein 425 0.4042 SUB21 >= 4 O 425 0.4042 PF01094 Receptor family ligand binding region 426 0.4038 SUB158 >= 3 any ring size 5 426 0.4038 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 427 0.4037 SUB16 >= 2 N 427 0.4037 PF02898 Nitric oxide synthase, oxygenase domain 428 0.4034 SUB295 C-Cl 428 0.4034 PF00043 Glutathione S-transferase, C-terminal domain 429 0.4027 SUB503 N-C=C-[#1] 429 0.4027 PF07885 Ion channel 430 0.4021 SUB686 O=C-C-C-C-N 430 0.4021 PF00755 Choline/Carnitine o-acyltransferase 431 0.4017 SUB337 C(~C)(~C)(~C)(~N) 431 0.4017 PF00060 Ligand-gated ion channel 432 0.4017 SUB618 C-C-C-O-[#1] 432 0.4017 PF00764 Arginosuccinate synthase 433 0.4015 SUB17 >= 4 N 433 0.4015 PF00211 Adenylate and Guanylate cyclase catalytic domain 434 0.3997 SUB430 C(#N)(-C) 434 0.3997 PF00625 Guanylate kinase 435 0.3996 SUB441 C(-C)(-O)(=O) 435 0.3996 PF00092 von Willebrand factor type A domain 436 0.3992 SUB19 >= 1 O 436 0.3992 PF00194 Eukaryotic-type carbonic anhydrase 437 0.3983 SUB667 C=C-C-O-C 437 0.3983 PF03953 Tubulin C-terminal domain 438 0.3974 SUB704 O-C-C-C-C-C(N)-C 438 0.3974 PF00282 Pyridoxal-dependent decarboxylase conserved domain 439 0.3970 SUB706 O=C-C-C-C-C(O)-C 439 0.3970 PF00104 Ligand-binding domain of nuclear hormone receptor 440 0.3958 SUB572 [#1]-C-O-[#1] 440 0.3958 PF00167 Fibroblast growth factor 441 0.3954 SUB691 O-C-C-C-C-C-O 441 0.3954 PF00070 Pyridine nucleotide-disulphide oxidoreductase 442 0.3950 SUB699 O-C-C-C-C-C-C-C 442 0.3950 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 443 0.3948 SUB444 C(-C)(=O) 443 0.3948 PF00413 Matrixin 444 0.3948 SUB381 C(~O)(~O) 444 0.3948 PF07686 Immunoglobulin V-set domain 445 0.3945 SUB257 >= 1 hetero-aromatic ring 445 0.3945 PF00067 Cytochrome P450 446 0.3939 SUB702 O-C-C-C-C-C(O)-C 446 0.3939 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 447 0.3923 SUB572 [#1]-C-O-[#1] 447 0.3923 PF00704 Glycosyl hydrolases family 18 448 0.3923 SUB536 O=C-C-C 448 0.3923 PF02166 Androgen receptor 449 0.3910 SUB537 O=C-C-N 449 0.3910 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 450 0.3884 SUB453 C(-O)(=O) 450 0.3884 PF03098 Animal haem peroxidase 451 0.3884 SUB407 O(~C)(~H) 451 0.3884 PF00273 Serum albumin family 452 0.3869 SUB431 C(-C)(-C)(=C) 452 0.3869 PF01593 Flavin containing amine oxidoreductase 453 0.3843 SUB529 [#1]-N-C-[#1] 453 0.3843 PF00310 Glutamine amidotransferases class-II 454 0.3817 SUB214 >= 1 any ring size 7 454 0.3817 PF02932 Neurotransmitter-gated ion-channel transmembrane region 455 0.3813 SUB466 O=S-C-C 455 0.3813 PF00045 Hemopexin 456 0.3807 SUB343 C(~C)(~Cl) 456 0.3807 PF03493 Calcium-activated BK potassium channel alpha subunit 457 0.3807 SUB537 O=C-C-N 457 0.3807 PF00458 WHEP-TRS domain 458 0.3798 SUB702 O-C-C-C-C-C(O)-C 458 0.3798 PF00128 Alpha amylase, catalytic domain 459 0.3791 SUB499 O-C=C-C 459 0.3791 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 460 0.3781 SUB454 N(-C)(=C) 460 0.3781 PF03073 TspO/MBR family 461 0.3780 SUB315 O-P 461 0.3780 PF02223 Thymidylate kinase 462 0.3768 SUB647 O=C-N-C-[#1] 462 0.3768 PF00303 Thymidylate synthase 463 0.3766 SUB680 C-C-C-C-C-C 463 0.3766 PF00089 Trypsin 464 0.3766 SUB738 Cc1cc(N)ccc1 464 0.3766 PF01122 Eukaryotic cobalamin-binding protein 465 0.3762 SUB686 O=C-C-C-C-N 465 0.3762 PF00153 Mitochondrial carrier protein 466 0.3752 SUB443 C(-C)(=N) 466 0.3752 PF00233 3"5"-cyclic nucleotide phosphodiesterase 467 0.3751 SUB567 O-C-C-N 467 0.3751 PF03917 Eukaryotic glutathione synthase, ATP binding domain 468 0.3748 SUB398 N(~C)(:C)(:C) 468 0.3748 PF02525 Flavodoxin-like fold 469 0.3743 SUB201 >= 4 saturated or aromatic carbon-only ring size 6 469 0.3743 PF00001 7 transmembrane receptor (rhodopsin family), 470 0.3743 SUB680 C-C-C-C-C-C 470 0.3743 PF00105 Zinc finger, C4 type (two domains), 471 0.3738 SUB407 O(~C)(~H) 471 0.3738 PF00248 Aldo/keto reductase family 472 0.3722 SUB348 C(~C)(~H)(~O)(~O) 472 0.3722 PF07686 Immunoglobulin V-set domain 473 0.3717 SUB243 >= 1 saturated or aromatic carbon-only ring size 9 473 0.3717 PF00191 Annexin 474 0.3710 SUB1 >= 4 H 474 0.3710 PF08674 Acetylcholinesterase tetramerisation domain 475 0.3709 SUB713 C-C(C)-C(C)-C 475 0.3709 PF00341 Platelet-derived growth factor (PDGF), 476 0.3707 SUB692 O-C-C-C-C-C-N 476 0.3707 PF00491 Arginase family 477 0.3707 SUB465 N-C-C=C 477 0.3707 PF00091 Tubulin/FtsZ family, GTPase domain 478 0.3705 SUB539 N=C-C-C 478 0.3705 PF00233 3"5"-cyclic nucleotide phosphodiesterase 479 0.3684 SUB406 O(~C)(~C) 479 0.3684 PF00122 E1-E2 ATPase 480 0.3683 SUB531 N:C-C:C 480 0.3683 PF02196 Raf-like Ras-binding domain 481 0.3674 SUB444 C(-C)(=O) 481 0.3674 PF00248 Aldo/keto reductase family 482 0.3666 SUB193 >= 3 any ring size 6 482 0.3666 PF06387 D1 dopamine receptor-interacting protein (calcyon), 483 0.3662 SUB300 N-H 483 0.3662 PF06512 Sodium ion transport-associated 484 0.3656 SUB695 O=C-C-C-C-C=O 484 0.3656 PF03951 Glutamine synthetase, beta-Grasp domain 485 0.3647 SUB151 >= 2 any ring size 5 485 0.3647 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 486 0.3642 SUB615 C-C-O-C-C 486 0.3642 PF03137 Organic Anion Transporter Polypeptide (OATP), family 487 0.3633 SUB529 [#1]-N-C-[#1] 487 0.3633 PF00155 Aminotransferase class I and II 488 0.3632 SUB249 >= 1 any ring size 10 488 0.3632 PF00521 DNA gyrase/topoisomerase IV, subunit A 489 0.3623 SUB378 C(~N)(:C)(:C) 489 0.3623 PF00005 ABC transporter 490 0.3621 SUB537 O=C-C-N 490 0.3621 PF00586 AIR synthase related protein, N-terminal domain 491 0.3621 SUB285 C-C 491 0.3621 PF00273 Serum albumin family 492 0.3621 SUB600 [#1]-C-C=C-[#1] 492 0.3621 PF00171 Aldehyde dehydrogenase family 493 0.3616 SUB347 C(~C)(~H)(~O) 493 0.3616 PF00089 Trypsin 494 0.3603 SUB433 C(-C)(-C)(=O) 494 0.3603 PF03953 Tubulin C-terminal domain 495 0.3580 SUB52 >= 1 Al 495 0.3580 PF01459 Eukaryotic porin 496 0.3573 SUB421 C=O 496 0.3573 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 497 0.3573 SUB602 N-C:C:C-N 497 0.3573 PF00017 SH2 domain 498 0.3562 SUB293 C-P 498 0.3562 PF00102 Protein-tyrosine phosphatase 499 0.3549 SUB200 >= 4 any ring size 6 499 0.3549 PF00520 Ion transport protein 500 0.3543 SUB489 N-C=N-[#1] 500 0.3543 PF00002 7 transmembrane receptor (Secretin family), 501 0.3543 SUB339 C(~C)(~C)(~H)(~N) 501 0.3543 PF01401 Angiotensin-converting enzyme 502 0.3541 SUB4 >= 32 H 502 0.3541 PF08441 Integrin alpha 503 0.3531 SUB762 Oc1c(O)cccc1 503 0.3531 PF01596 O-methyltransferase 504 0.3523 SUB467 N#C-C=C 504 0.3523 PF00105 Zinc finger, C4 type (two domains), 505 0.3520 SUB686 O=C-C-C-C-N 505 0.3520 PF00023 Ankyrin repeat 506 0.3515 SUB444 C(-C)(=O) 506 0.3515 PF00266 Aminotransferase class-V 507 0.3501 SUB441 C(-C)(-O)(=O) 507 0.3501 PF01063 Aminotransferase class IV 508 0.3496 SUB572 [#1]-C-O-[#1] 508 0.3496 PF00169 PH domain 509 0.3494 SUB618 C-C-C-O-[#1] 509 0.3494 PF00128 Alpha amylase, catalytic domain 510 0.3494 SUB793 NC1CCC(Cl)CC1 510 0.3494 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 511 0.3480 SUB25 >= 2 F 511 0.3480 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 512 0.3472 SUB692 O-C-C-C-C-C-N 512 0.3472 PF03807 NADP oxidoreductase coenzyme F420-dependent 513 0.3463 SUB465 N-C-C=C 513 0.3463 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 514 0.3456 SUB712 C-C(C)(C)-C-C 514 0.3456 PF00976 Corticotropin ACTH domain 515 0.3446 SUB3 >= 16 H 515 0.3446 PF00664 ABC transporter transmembrane region 516 0.3441 SUB708 O=C-C-C-C-C(N)-C 516 0.3441 PF02219 Methylenetetrahydrofolate reductase 517 0.3416 SUB21 >= 4 O 517 0.3416 PF07992 Pyridine nucleotide-disulphide oxidoreductase 518 0.3410 SUB536 O=C-C-C 518 0.3410 PF00001 7 transmembrane receptor (rhodopsin family), 519 0.3410 SUB368 C(~H)(~O)(~O) 519 0.3410 PF07686 Immunoglobulin V-set domain 520 0.3409 SUB664 O-C-C-O-[#1] 520 0.3409 PF01842 ACT domain 521 0.3401 SUB606 O=C-C-O-C 521 0.3401 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 522 0.3401 SUB674 O=C-C=C-N 522 0.3401 PF02219 Methylenetetrahydrofolate reductase 523 0.3399 SUB158 >= 3 any ring size 5 523 0.3399 PF00171 Aldehyde dehydrogenase family 524 0.3398 SUB698 C-C-C-C-C-C(C)-C 524 0.3398 PF00149 Calcineurin-like phosphoesterase 525 0.3396 SUB495 O=C-C:N 525 0.3396 PF00227 Proteasome subunit 526 0.3394 SUB486 N:C:C:N 526 0.3394 PF00520 Ion transport protein 527 0.3384 SUB346 C(~C)(~H)(~N) 527 0.3384 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 528 0.3383 SUB647 O=C-N-C-[#1] 528 0.3383 PF05649 Peptidase family M13 529 0.3376 SUB699 O-C-C-C-C-C-C-C 529 0.3376 PF01477 PLAT/LH2 domain 530 0.3376 SUB454 N(-C)(=C) 530 0.3376 PF00069 Protein kinase domain 531 0.3363 SUB691 O-C-C-C-C-C-O 531 0.3363 PF00551 Formyl transferase 532 0.3362 SUB554 O=C-C=C 532 0.3362 PF02525 Flavodoxin-like fold 533 0.3359 SUB624 O=C-C:C-C 533 0.3359 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 534 0.3359 SUB800 CC1CC(S)CCC1 534 0.3359 PF00001 7 transmembrane receptor (rhodopsin family), 535 0.3353 SUB682 O-C-C-C-C-O 535 0.3353 PF00169 PH domain 536 0.3352 SUB543 O-C:C-[#1] 536 0.3352 PF00656 Caspase domain 537 0.3351 SUB313 O-Al 537 0.3351 PF01459 Eukaryotic porin 538 0.3330 SUB335 C(~C)(~C)(~C)(~C) 538 0.3330 PF00091 Tubulin/FtsZ family, GTPase domain 539 0.3329 SUB13 >= 16 C 539 0.3329 PF00001 7 transmembrane receptor (rhodopsin family), 540 0.3320 SUB394 N(~C)(~H) 540 0.3320 PF02008 CXXC zinc finger domain 541 0.3319 SUB595 C-O-C-C=C 541 0.3319 PF03953 Tubulin C-terminal domain 542 0.3314 SUB10 >= 2 C 542 0.3314 PF00273 Serum albumin family 543 0.3308 SUB772 Nc1c(Cl)cccc1 543 0.3308 PF00001 7 transmembrane receptor (rhodopsin family), 544 0.3308 SUB618 C-C-C-O-[#1] 544 0.3308 PF00927 Transglutaminase family, C-terminal ig like domain 545 0.3302 SUB392 N(~C)(~C)(~C) 545 0.3302 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 546 0.3302 SUB489 N-C=N-[#1] 546 0.3302 PF00217 ATP:guanido phosphotransferase, C-terminal catalytic domain 547 0.3301 SUB582 O=C-C-C-O 547 0.3301 PF00091 Tubulin/FtsZ family, GTPase domain 548 0.3298 SUB781 CC1CCC(Cl)CC1 548 0.3298 PF01094 Receptor family ligand binding region 549 0.3297 SUB252 >= 1 saturated or aromatic heteroatom-containing ring size 10 549 0.3297 PF01582 TIR domain 550 0.3295 SUB537 O=C-C-N 550 0.3295 PF00233 3"5"-cyclic nucleotide phosphodiesterase 551 0.3291 SUB339 C(~C)(~C)(~H)(~N) 551 0.3291 PF00112 Papain family cysteine protease 552 0.3289 SUB392 N(~C)(~C)(~C) 552 0.3289 PF01467 Cytidylyltransferase 553 0.3287 SUB629 C-N-C-C:C 553 0.3287 PF01234 NNMT/PNMT/TEMT family 554 0.3281 SUB578 C:C-N-C:C 554 0.3281 PF00291 Pyridoxal-phosphate dependent enzyme 555 0.3280 SUB4 >= 32 H 555 0.3280 PF03137 Organic Anion Transporter Polypeptide (OATP), family 556 0.3265 SUB151 >= 2 any ring size 5 556 0.3265 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 557 0.3257 SUB258 >= 2 aromatic rings 557 0.3257 PF00005 ABC transporter 558 0.3250 SUB579 C-C:C-C:C 558 0.3250 PF00001 7 transmembrane receptor (rhodopsin family), 559 0.3250 SUB389 C(:C)(:N)(:N) 559 0.3250 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 560 0.3245 SUB567 O-C-C-N 560 0.3245 PF00310 Glutamine amidotransferases class-II 561 0.3209 SUB466 O=S-C-C 561 0.3209 PF08403 Amino acid permease N-terminal 562 0.3209 SUB346 C(~C)(~H)(~N) 562 0.3209 PF00001 7 transmembrane receptor (rhodopsin family), 563 0.3198 SUB756 Cc1c(C)cccc1 563 0.3198 PF00069 Protein kinase domain 564 0.3198 SUB691 O-C-C-C-C-C-O 564 0.3198 PF07654 Immunoglobulin C1-set domain 565 0.3192 SUB548 N-C:C-N 565 0.3192 PF01687 Riboflavin kinase 566 0.3186 SUB539 N=C-C-C 566 0.3186 PF03073 TspO/MBR family 567 0.3178 SUB735 Cc1cc(C)ccc1 567 0.3178 PF01030 Receptor L domain 568 0.3164 SUB709 C-C(C)-C-C 568 0.3164 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 569 0.3149 SUB702 O-C-C-C-C-C(O)-C 569 0.3149 PF01055 Glycosyl hydrolases family 31 570 0.3142 SUB193 >= 3 any ring size 6 570 0.3142 PF00018 SH3 domain 571 0.3141 SUB696 O=C-C-C-C-C-N 571 0.3141 PF02100 Ornithine decarboxylase antizyme 572 0.3141 SUB587 C-S-C-C-C 572 0.3141 PF02772 S-adenosylmethionine synthetase, central domain 573 0.3141 SUB780 CC1CCC(N)CC1 573 0.3141 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 574 0.3134 SUB548 N-C:C-N 574 0.3134 PF01048 Phosphorylase superfamily 575 0.3118 SUB698 C-C-C-C-C-C(C)-C 575 0.3118 PF00520 Ion transport protein 576 0.3114 SUB687 O=C-C-C-C-O 576 0.3114 PF01336 OB-fold nucleic acid binding domain 577 0.3110 SUB572 [#1]-C-O-[#1] 577 0.3110 PF00145 C-5 cytosine-specific DNA methylase 578 0.3098 SUB694 O=C-C-C-C-C-O 578 0.3098 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 579 0.3094 SUB668 C=C-C-O-[#1] 579 0.3094 PF00001 7 transmembrane receptor (rhodopsin family), 580 0.3090 SUB686 O=C-C-C-C-N 580 0.3090 PF00375 Sodium:dicarboxylate symporter family 581 0.3087 SUB633 C-C-O-C:C 581 0.3087 PF00757 Furin-like cysteine rich region 582 0.3087 SUB537 O=C-C-N 582 0.3087 PF02769 AIR synthase related protein, C-terminal domain 583 0.3080 SUB408 O(~C)(~P) 583 0.3080 PF00169 PH domain 584 0.3077 SUB593 N-C-C-C-C 584 0.3077 PF00102 Protein-tyrosine phosphatase 585 0.3073 SUB536 O=C-C-C 585 0.3073 PF00071 Ras family 586 0.3065 SUB392 N(~C)(~C)(~C) 586 0.3065 PF00520 Ion transport protein 587 0.3063 SUB695 O=C-C-C-C-C=O 587 0.3063 PF08240 Alcohol dehydrogenase GroES-like domain 588 0.3058 SUB672 O=C-C=C-C 588 0.3058 PF00005 ABC transporter 589 0.3055 SUB22 >= 8 O 589 0.3055 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 590 0.3053 SUB500 N-C:C:N 590 0.3053 PF00233 3"5"-cyclic nucleotide phosphodiesterase 591 0.3046 SUB438 C(-C)(-N)(=C) 591 0.3046 PF00520 Ion transport protein 592 0.3040 SUB398 N(~C)(:C)(:C) 592 0.3040 PF01467 Cytidylyltransferase 593 0.3033 SUB346 C(~C)(~H)(~N) 593 0.3033 PF03073 TspO/MBR family 594 0.3031 SUB682 O-C-C-C-C-O 594 0.3031 PF00079 Serpin (serine protease inhibitor), 595 0.3029 SUB639 O-C-C-C-N 595 0.3029 PF00088 Trefoil (P-type), domain 596 0.3029 SUB32 >= 2 P 596 0.3029 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 597 0.3026 SUB158 >= 3 any ring size 5 597 0.3026 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 598 0.3026 SUB16 >= 2 N 598 0.3026 PF02932 Neurotransmitter-gated ion-channel transmembrane region 599 0.3025 SUB348 C(~C)(~H)(~O)(~O) 599 0.3025 PF08702 Fibrinogen alpha/beta chain family 600 0.3025 SUB21 >= 4 O 600 0.3025 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 601 0.3024 SUB814 NC1CC(Cl)CCC1 601 0.3024 PF00043 Glutathione S-transferase, C-terminal domain 602 0.3022 SUB703 O-C-C-C-C-C-N-C 602 0.3022 PF00211 Adenylate and Guanylate cyclase catalytic domain 603 0.3021 SUB590 C-C:C-O-C 603 0.3021 PF00664 ABC transporter transmembrane region 604 0.3020 SUB759 Cc1c(N)cccc1 604 0.3020 PF00017 SH2 domain 605 0.3017 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 605 0.3017 PF00248 Aldo/keto reductase family 606 0.3002 SUB335 C(~C)(~C)(~C)(~C) 606 0.3002 PF08384 Pro-opiomelanocortin, N-terminal region 607 0.3000 SUB341 C(~C)(~C)(~N) 607 0.3000 PF00291 Pyridoxal-phosphate dependent enzyme 608 0.2997 SUB400 N(~H)(:C) 608 0.2997 PF00001 7 transmembrane receptor (rhodopsin family), 609 0.2986 SUB738 Cc1cc(N)ccc1 609 0.2986 PF00104 Ligand-binding domain of nuclear hormone receptor 610 0.2977 SUB13 >= 16 C 610 0.2977 PF00105 Zinc finger, C4 type (two domains), 611 0.2973 SUB440 C(-C)(-N)(=O) 611 0.2973 PF00868 Transglutaminase family 612 0.2971 SUB353 C(~C)(~O) 612 0.2971 PF02932 Neurotransmitter-gated ion-channel transmembrane region 613 0.2969 SUB381 C(~O)(~O) 613 0.2969 PF00224 Pyruvate kinase, barrel domain 614 0.2968 SUB621 C:C-O-C-C 614 0.2968 PF00105 Zinc finger, C4 type (two domains), 615 0.2960 SUB441 C(-C)(-O)(=O) 615 0.2960 PF00105 Zinc finger, C4 type (two domains), 616 0.2956 SUB694 O=C-C-C-C-C-O 616 0.2956 PF00229 TNF(Tumour Necrosis Factor), family 617 0.2944 SUB341 C(~C)(~C)(~N) 617 0.2944 PF00155 Aminotransferase class I and II 618 0.2939 SUB801 CC1CC(N)CCC1 618 0.2939 PF02166 Androgen receptor 619 0.2926 SUB130 >= 1 any ring size 4 619 0.2926 PF00854 POT family 620 0.2923 SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 620 0.2923 PF00104 Ligand-binding domain of nuclear hormone receptor 621 0.2917 SUB582 O=C-C-C-O 621 0.2917 PF00271 Helicase conserved C-terminal domain 622 0.2917 SUB529 [#1]-N-C-[#1] 622 0.2917 PF00001 7 transmembrane receptor (rhodopsin family), 623 0.2916 SUB621 C:C-O-C-C 623 0.2916 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 624 0.2894 SUB598 O=C-C-C:C 624 0.2894 PF00069 Protein kinase domain 625 0.2876 SUB25 >= 2 F 625 0.2876 PF00146 NADH dehydrogenase 626 0.2874 SUB144 >= 1 any ring size 5 626 0.2874 PF00067 Cytochrome P450 627 0.2873 SUB615 C-C-O-C-C 627 0.2873 PF00079 Serpin (serine protease inhibitor), 628 0.2873 SUB640 O-C-C-C-O 628 0.2873 PF00071 Ras family 629 0.2866 SUB15 >= 1 N 629 0.2866 PF01094 Receptor family ligand binding region 630 0.2864 SUB369 C(~H)(~S) 630 0.2864 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 631 0.2864 SUB825 OC1C(O)CCCC1 631 0.2864 PF02932 Neurotransmitter-gated ion-channel transmembrane region 632 0.2857 SUB673 O=C-C=C-[#1] 632 0.2857 PF00089 Trypsin 633 0.2855 SUB713 C-C(C)-C(C)-C 633 0.2855 PF00079 Serpin (serine protease inhibitor), 634 0.2851 SUB695 O=C-C-C-C-C=O 634 0.2851 PF00120 Glutamine synthetase, catalytic domain 635 0.2846 SUB249 >= 1 any ring size 10 635 0.2846 PF07690 Major Facilitator Superfamily 636 0.2846 SUB441 C(-C)(-O)(=O) 636 0.2846 PF00571 CBS domain 637 0.2843 SUB660 O-C-C-N-C 637 0.2843 PF04515 Plasma-membrane choline transporter 638 0.2835 SUB529 [#1]-N-C-[#1] 638 0.2835 PF00112 Papain family cysteine protease 639 0.2835 SUB39 >= 2 Cl 639 0.2835 PF00689 Cation transporting ATPase, C-terminus 640 0.2831 SUB672 O=C-C=C-C 640 0.2831 PF00104 Ligand-binding domain of nuclear hormone receptor 641 0.2830 SUB712 C-C(C)(C)-C-C 641 0.2830 PF08384 Pro-opiomelanocortin, N-terminal region 642 0.2824 SUB457 P(-O)(=O) 642 0.2824 PF00017 SH2 domain 643 0.2812 SUB792 NC1CCC(N)CC1 643 0.2812 PF00001 7 transmembrane receptor (rhodopsin family), 644 0.2805 SUB407 O(~C)(~H) 644 0.2805 PF00202 Aminotransferase class-III 645 0.2790 SUB779 CC1CCC(S)CC1 645 0.2790 PF00005 ABC transporter 646 0.2789 SUB356 C(~C)(:C) 646 0.2789 PF00001 7 transmembrane receptor (rhodopsin family), 647 0.2783 SUB17 >= 4 N 647 0.2783 PF00067 Cytochrome P450 648 0.2783 SUB643 O-C-C-C=O 648 0.2783 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 649 0.2778 SUB348 C(~C)(~H)(~O)(~O) 649 0.2778 PF00089 Trypsin 650 0.2774 SUB540 N=C-C-[#1] 650 0.2774 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 651 0.2774 SUB715 Cc1ccc(O)cc1 651 0.2774 PF00018 SH3 domain 652 0.2773 SUB259 >= 2 hetero-aromatic rings 652 0.2773 PF00042 Globin 653 0.2763 SUB647 O=C-N-C-[#1] 653 0.2763 PF00005 ABC transporter 654 0.2761 SUB709 C-C(C)-C-C 654 0.2761 PF02932 Neurotransmitter-gated ion-channel transmembrane region 655 0.2758 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 655 0.2758 PF00045 Hemopexin 656 0.2756 SUB546 N-C:C-C 656 0.2756 PF00520 Ion transport protein 657 0.2754 SUB739 Cc1cc(Cl)ccc1 657 0.2754 PF02932 Neurotransmitter-gated ion-channel transmembrane region 658 0.2748 SUB659 C-C-S-C-C 658 0.2748 PF00001 7 transmembrane receptor (rhodopsin family), 659 0.2747 SUB13 >= 16 C 659 0.2747 PF00067 Cytochrome P450 660 0.2745 SUB446 C(-H)(-N)(=C) 660 0.2745 PF00107 Zinc-binding dehydrogenase 661 0.2738 SUB619 C:C-C-C:C 661 0.2738 PF00209 Sodium:neurotransmitter symporter family 662 0.2725 SUB634 N-C-C:C-C 662 0.2725 PF00702 haloacid dehalogenase-like hydrolase 663 0.2721 SUB394 N(~C)(~H) 663 0.2721 PF00051 Kringle domain 664 0.2713 SUB622 N-C:C:C:N 664 0.2713 PF00757 Furin-like cysteine rich region 665 0.2711 SUB640 O-C-C-C-O 665 0.2711 PF00069 Protein kinase domain 666 0.2709 SUB328 C(~Br)(~C) 666 0.2709 PF00001 7 transmembrane receptor (rhodopsin family), 667 0.2697 SUB700 O-C-C-C-C-C(C)-C 667 0.2697 PF00042 Globin 668 0.2692 SUB736 Cc1cc(O)ccc1 668 0.2692 PF00001 7 transmembrane receptor (rhodopsin family), 669 0.2690 SUB408 O(~C)(~P) 669 0.2690 PF00070 Pyridine nucleotide-disulphide oxidoreductase 670 0.2686 SUB616 N-C-C-O-C 670 0.2686 PF00067 Cytochrome P450 671 0.2683 SUB339 C(~C)(~C)(~H)(~N) 671 0.2683 PF02574 Homocysteine S-methyltransferase 672 0.2681 SUB309 O-H 672 0.2681 PF00273 Serum albumin family 673 0.2673 SUB369 C(~H)(~S) 673 0.2673 PF00043 Glutathione S-transferase, C-terminal domain 674 0.2668 SUB21 >= 4 O 674 0.2668 PF00413 Matrixin 675 0.2668 SUB42 >= 1 K 675 0.2668 PF00324 Amino acid permease 676 0.2666 SUB284 C-H 676 0.2666 PF00273 Serum albumin family 677 0.2665 SUB275 B-C 677 0.2665 PF00227 Proteasome subunit 678 0.2664 SUB537 O=C-C-N 678 0.2664 PF00102 Protein-tyrosine phosphatase 679 0.2662 SUB537 O=C-C-N 679 0.2662 PF02142 MGS-like domain 680 0.2661 SUB498 O-C:C:N 680 0.2661 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 681 0.2651 SUB20 >= 2 O 681 0.2651 PF00194 Eukaryotic-type carbonic anhydrase 682 0.2649 SUB284 C-H 682 0.2649 PF08674 Acetylcholinesterase tetramerisation domain 683 0.2647 SUB515 O-N-C-C 683 0.2647 PF00045 Hemopexin 684 0.2640 SUB389 C(:C)(:N)(:N) 684 0.2640 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 685 0.2629 SUB339 C(~C)(~C)(~H)(~N) 685 0.2629 PF00155 Aminotransferase class I and II 686 0.2624 SUB22 >= 8 O 686 0.2624 PF00171 Aldehyde dehydrogenase family 687 0.2622 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 687 0.2622 PF00702 haloacid dehalogenase-like hydrolase 688 0.2621 SUB840 CC1CC(C)CC1 688 0.2621 PF00105 Zinc finger, C4 type (two domains), 689 0.2619 SUB488 N-C=N-C 689 0.2619 PF00206 Lyase 690 0.2617 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 690 0.2617 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 691 0.2612 SUB352 C(~C)(~N) 691 0.2612 PF00001 7 transmembrane receptor (rhodopsin family), 692 0.2610 SUB353 C(~C)(~O) 692 0.2610 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 693 0.2609 SUB350 C(~C)(~H)(~S) 693 0.2609 PF08725 Integrin beta cytoplasmic domain 694 0.2607 SUB674 O=C-C=C-N 694 0.2607 PF01808 AICARFT/IMPCHase bienzyme 695 0.2607 SUB618 C-C-C-O-[#1] 695 0.2607 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 696 0.2606 SUB441 C(-C)(-O)(=O) 696 0.2606 PF01433 Peptidase family M1 697 0.2591 SUB683 O-C-C-C-C-N 697 0.2591 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 698 0.2588 SUB594 N-C-C-C-N 698 0.2588 PF00089 Trypsin 699 0.2579 SUB633 C-C-O-C:C 699 0.2579 PF00105 Zinc finger, C4 type (two domains), 700 0.2578 SUB394 N(~C)(~H) 700 0.2578 PF01593 Flavin containing amine oxidoreductase 701 0.2576 SUB259 >= 2 hetero-aromatic rings 701 0.2576 PF00018 SH3 domain 702 0.2576 SUB462 O-C-C=N 702 0.2576 PF00155 Aminotransferase class I and II 703 0.2573 SUB639 O-C-C-C-N 703 0.2573 PF00001 7 transmembrane receptor (rhodopsin family), 704 0.2570 SUB492 C-N:C-[#1] 704 0.2570 PF01471 Putative peptidoglycan binding domain 705 0.2564 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 705 0.2564 PF00079 Serpin (serine protease inhibitor), 706 0.2562 SUB793 NC1CCC(Cl)CC1 706 0.2562 PF02932 Neurotransmitter-gated ion-channel transmembrane region 707 0.2557 SUB431 C(-C)(-C)(=C) 707 0.2557 PF00171 Aldehyde dehydrogenase family 708 0.2556 SUB407 O(~C)(~H) 708 0.2556 PF00106 short chain dehydrogenase 709 0.2551 SUB528 C:C:N-[#1] 709 0.2551 PF00001 7 transmembrane receptor (rhodopsin family), 710 0.2549 SUB564 O-C-O-C 710 0.2549 PF02806 Alpha amylase, C-terminal all-beta domain 711 0.2547 SUB785 OC1CCC(N)CC1 711 0.2547 PF07885 Ion channel 712 0.2529 SUB644 [#1]-C-C-N-[#1] 712 0.2529 PF00018 SH3 domain 713 0.2528 SUB825 OC1C(O)CCCC1 713 0.2528 PF03953 Tubulin C-terminal domain 714 0.2522 SUB484 N-S-C:C 714 0.2522 PF00194 Eukaryotic-type carbonic anhydrase 715 0.2521 SUB179 >= 1 any ring size 6 715 0.2521 PF00089 Trypsin 716 0.2519 SUB356 C(~C)(:C) 716 0.2519 PF00233 3"5"-cyclic nucleotide phosphodiesterase 717 0.2518 SUB381 C(~O)(~O) 717 0.2518 PF01401 Angiotensin-converting enzyme 718 0.2514 SUB261 >= 3 hetero-aromatic rings 718 0.2514 PF00106 short chain dehydrogenase 719 0.2514 SUB451 C(-N)(=N) 719 0.2514 PF00089 Trypsin 720 0.2513 SUB738 Cc1cc(N)ccc1 720 0.2513 PF00175 Oxidoreductase NAD-binding domain 721 0.2501 SUB643 O-C-C-C=O 721 0.2501 PF01023 S-100/ICaBP type calcium binding domain 722 0.2496 SUB644 [#1]-C-C-N-[#1] 722 0.2496 PF00069 Protein kinase domain 723 0.2467 SUB580 O=C-C-C-C 723 0.2467 PF00248 Aldo/keto reductase family 724 0.2465 SUB433 C(-C)(-C)(=O) 724 0.2465 PF02525 Flavodoxin-like fold 725 0.2455 SUB664 O-C-C-O-[#1] 725 0.2455 PF00180 Isocitrate/isopropylmalate dehydrogenase 726 0.2454 SUB735 Cc1cc(C)ccc1 726 0.2454 PF00105 Zinc finger, C4 type (two domains), 727 0.2444 SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 727 0.2444 PF02525 Flavodoxin-like fold 728 0.2436 SUB627 C-O-C:C-C 728 0.2436 PF08441 Integrin alpha 729 0.2436 SUB354 C(~C)(~S) 729 0.2436 PF00690 Cation transporter/ATPase, N-terminus 730 0.2435 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 730 0.2435 PF00089 Trypsin 731 0.2431 SUB339 C(~C)(~C)(~H)(~N) 731 0.2431 PF07562 Nine Cysteines Domain of family 3 GPCR 732 0.2427 SUB620 O-C-C=C-C 732 0.2427 PF00702 haloacid dehalogenase-like hydrolase 733 0.2427 SUB666 N-C:C-C-C 733 0.2427 PF06512 Sodium ion transport-associated 734 0.2423 SUB406 O(~C)(~C) 734 0.2423 PF00001 7 transmembrane receptor (rhodopsin family), 735 0.2422 SUB664 O-C-C-O-[#1] 735 0.2422 PF03414 Glycosyltransferase family 6 736 0.2422 SUB572 [#1]-C-O-[#1] 736 0.2422 PF00001 7 transmembrane receptor (rhodopsin family), 737 0.2421 SUB343 C(~C)(~Cl) 737 0.2421 PF00084 Sushi domain (SCR repeat), 738 0.2417 SUB13 >= 16 C 738 0.2417 PF00104 Ligand-binding domain of nuclear hormone receptor 739 0.2412 SUB366 C(~H)(~N) 739 0.2412 PF00001 7 transmembrane receptor (rhodopsin family), 740 0.2409 SUB18 >= 8 N 740 0.2409 PF00001 7 transmembrane receptor (rhodopsin family), 741 0.2408 SUB394 N(~C)(~H) 741 0.2408 PF00186 Dihydrofolate reductase 742 0.2403 SUB366 C(~H)(~N) 742 0.2403 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 743 0.2397 SUB613 N-C-O-C-C 743 0.2397 PF02267 ADP-ribosyl cyclase 744 0.2393 SUB660 O-C-C-N-C 744 0.2393 PF00005 ABC transporter 745 0.2390 SUB60 >= 1 Co 745 0.2390 PF01122 Eukaryotic cobalamin-binding protein 746 0.2385 SUB520 N=C-N-C 746 0.2385 PF01048 Phosphorylase superfamily 747 0.2381 SUB309 O-H 747 0.2381 PF00576 HIUase/Transthyretin family 748 0.2373 SUB406 O(~C)(~C) 748 0.2373 PF00690 Cation transporter/ATPase, N-terminus 749 0.2371 SUB354 C(~C)(~S) 749 0.2371 PF02798 Glutathione S-transferase, N-terminal domain 750 0.2367 SUB415 S(~C)(~O) 750 0.2367 PF08403 Amino acid permease N-terminal 751 0.2366 SUB406 O(~C)(~C) 751 0.2366 PF00135 Carboxylesterase 752 0.2365 SUB694 O=C-C-C-C-C-O 752 0.2365 PF07654 Immunoglobulin C1-set domain 753 0.2355 SUB681 O-C-C-C-C-C 753 0.2355 PF00067 Cytochrome P450 754 0.2352 SUB801 CC1CC(N)CCC1 754 0.2352 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 755 0.2341 SUB459 S(-O)(=O) 755 0.2341 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 756 0.2335 SUB287 C-O 756 0.2335 PF02932 Neurotransmitter-gated ion-channel transmembrane region 757 0.2332 SUB394 N(~C)(~H) 757 0.2332 PF01179 Copper amine oxidase, enzyme domain 758 0.2323 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 758 0.2323 PF00001 7 transmembrane receptor (rhodopsin family), 759 0.2322 SUB708 O=C-C-C-C-C(N)-C 759 0.2322 PF01571 Aminomethyltransferase folate-binding domain 760 0.2317 SUB825 OC1C(O)CCCC1 760 0.2317 PF01596 O-methyltransferase 761 0.2309 SUB31 >= 1 P 761 0.2309 PF02223 Thymidylate kinase 762 0.2295 SUB44 >= 1 Br 762 0.2295 PF00001 7 transmembrane receptor (rhodopsin family), 763 0.2293 SUB573 N:C:N:C 763 0.2293 PF00067 Cytochrome P450 764 0.2290 SUB574 O-C-C=C 764 0.2290 PF00702 haloacid dehalogenase-like hydrolase 765 0.2287 SUB503 N-C=C-[#1] 765 0.2287 PF00067 Cytochrome P450 766 0.2286 SUB407 O(~C)(~H) 766 0.2286 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 767 0.2280 SUB500 N-C:C:N 767 0.2280 PF00069 Protein kinase domain 768 0.2280 SUB537 O=C-C-N 768 0.2280 PF00248 Aldo/keto reductase family 769 0.2276 SUB354 C(~C)(~S) 769 0.2276 PF00689 Cation transporting ATPase, C-terminus 770 0.2274 SUB612 N-C-C-N-C 770 0.2274 PF08246 Cathepsin propeptide inhibitor domain (I29), 771 0.2273 SUB691 O-C-C-C-C-C-O 771 0.2273 PF01230 HIT domain 772 0.2271 SUB295 C-Cl 772 0.2271 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 773 0.2266 SUB335 C(~C)(~C)(~C)(~C) 773 0.2266 PF00104 Ligand-binding domain of nuclear hormone receptor 774 0.2260 SUB664 O-C-C-O-[#1] 774 0.2260 PF00328 Histidine acid phosphatase 775 0.2260 SUB780 CC1CCC(N)CC1 775 0.2260 PF02932 Neurotransmitter-gated ion-channel transmembrane region 776 0.2259 SUB632 O-C:C-O-[#1] 776 0.2259 PF00001 7 transmembrane receptor (rhodopsin family), 777 0.2258 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 777 0.2258 PF00067 Cytochrome P450 778 0.2257 SUB348 C(~C)(~H)(~O)(~O) 778 0.2257 PF07654 Immunoglobulin C1-set domain 779 0.2251 SUB691 O-C-C-C-C-C-O 779 0.2251 PF00180 Isocitrate/isopropylmalate dehydrogenase 780 0.2246 SUB640 O-C-C-C-O 780 0.2246 PF00341 Platelet-derived growth factor (PDGF), 781 0.2235 SUB386 C(:C)(:C)(:C) 781 0.2235 PF01582 TIR domain 782 0.2234 SUB440 C(-C)(-N)(=O) 782 0.2234 PF00927 Transglutaminase family, C-terminal ig like domain 783 0.2227 SUB338 C(~C)(~C)(~C)(~O) 783 0.2227 PF00001 7 transmembrane receptor (rhodopsin family), 784 0.2221 SUB567 O-C-C-N 784 0.2221 PF00324 Amino acid permease 785 0.2219 SUB451 C(-N)(=N) 785 0.2219 PF00001 7 transmembrane receptor (rhodopsin family), 786 0.2213 SUB309 O-H 786 0.2213 PF00106 short chain dehydrogenase 787 0.2192 SUB621 C:C-O-C-C 787 0.2192 PF00233 3"5"-cyclic nucleotide phosphodiesterase 788 0.2187 SUB504 Cl-C:C-[#1] 788 0.2187 PF00067 Cytochrome P450 789 0.2182 SUB34 >= 1 S 789 0.2182 PF00167 Fibroblast growth factor 790 0.2177 SUB440 C(-C)(-N)(=O) 790 0.2177 PF00079 Serpin (serine protease inhibitor), 791 0.2169 SUB499 O-C=C-C 791 0.2169 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 792 0.2168 SUB392 N(~C)(~C)(~C) 792 0.2168 PF00209 Sodium:neurotransmitter symporter family 793 0.2164 SUB594 N-C-C-C-N 793 0.2164 PF00149 Calcineurin-like phosphoesterase 794 0.2164 SUB572 [#1]-C-O-[#1] 794 0.2164 PF00069 Protein kinase domain 795 0.2160 SUB441 C(-C)(-O)(=O) 795 0.2160 PF00151 Lipase 796 0.2160 SUB381 C(~O)(~O) 796 0.2160 PF00059 Lectin C-type domain 797 0.2156 SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 797 0.2156 PF00001 7 transmembrane receptor (rhodopsin family), 798 0.2156 SUB498 O-C:C:N 798 0.2156 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 799 0.2154 SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 799 0.2154 PF00106 short chain dehydrogenase 800 0.2151 SUB419 C=N 800 0.2151 PF02898 Nitric oxide synthase, oxygenase domain 801 0.2145 SUB340 C(~C)(~C)(~H)(~O) 801 0.2145 PF00027 Cyclic nucleotide-binding domain 802 0.2142 SUB672 O=C-C=C-C 802 0.2142 PF00229 TNF(Tumour Necrosis Factor), family 803 0.2137 SUB691 O-C-C-C-C-C-O 803 0.2137 PF00349 Hexokinase 804 0.2136 SUB32 >= 2 P 804 0.2136 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 805 0.2134 SUB336 C(~C)(~C)(~C)(~H) 805 0.2134 PF08763 Voltage gated calcium channel IQ domain 806 0.2131 SUB597 N=C-N-C-C 806 0.2131 PF00233 3"5"-cyclic nucleotide phosphodiesterase 807 0.2131 SUB489 N-C=N-[#1] 807 0.2131 PF02793 Hormone receptor domain 808 0.2129 SUB598 O=C-C-C:C 808 0.2129 PF07884 Vitamin K epoxide reductase family 809 0.2129 SUB336 C(~C)(~C)(~C)(~H) 809 0.2129 PF00045 Hemopexin 810 0.2125 SUB612 N-C-C-N-C 810 0.2125 PF03073 TspO/MBR family 811 0.2122 SUB572 [#1]-C-O-[#1] 811 0.2122 PF00175 Oxidoreductase NAD-binding domain 812 0.2110 SUB656 O-C-C-C:C 812 0.2110 PF00989 PAS fold 813 0.2104 SUB675 N-C-N-C:C 813 0.2104 PF00186 Dihydrofolate reductase 814 0.2100 SUB284 C-H 814 0.2100 PF00060 Ligand-gated ion channel 815 0.2087 SUB426 P=O 815 0.2087 PF02223 Thymidylate kinase 816 0.2084 SUB3 >= 16 H 816 0.2084 PF00106 short chain dehydrogenase 817 0.2084 SUB627 C-O-C:C-C 817 0.2084 PF00664 ABC transporter transmembrane region 818 0.2083 SUB681 O-C-C-C-C-C 818 0.2083 PF00501 AMP-binding enzyme 819 0.2081 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 819 0.2081 PF02932 Neurotransmitter-gated ion-channel transmembrane region 820 0.2079 SUB572 [#1]-C-O-[#1] 820 0.2079 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 821 0.2067 SUB20 >= 2 O 821 0.2067 PF00074 Pancreatic ribonuclease 822 0.2065 SUB315 O-P 822 0.2065 PF00018 SH3 domain 823 0.2061 SUB180 >= 1 saturated or aromatic carbon-only ring size 6 823 0.2061 PF00001 7 transmembrane receptor (rhodopsin family), 824 0.2061 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 824 0.2061 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 825 0.2052 SUB341 C(~C)(~C)(~N) 825 0.2052 PF00310 Glutamine amidotransferases class-II 826 0.2044 SUB21 >= 4 O 826 0.2044 PF03949 Malic enzyme, NAD binding domain 827 0.2043 SUB284 C-H 827 0.2043 PF00248 Aldo/keto reductase family 828 0.2042 SUB387 C(:C)(:C)(:N) 828 0.2042 PF00001 7 transmembrane receptor (rhodopsin family), 829 0.2037 SUB621 C:C-O-C-C 829 0.2037 PF01023 S-100/ICaBP type calcium binding domain 830 0.2035 SUB703 O-C-C-C-C-C-N-C 830 0.2035 PF00069 Protein kinase domain 831 0.2033 SUB453 C(-O)(=O) 831 0.2033 PF00571 CBS domain 832 0.2033 SUB756 Cc1c(C)cccc1 832 0.2033 PF00643 B-box zinc finger 833 0.2031 SUB682 O-C-C-C-C-O 833 0.2031 PF03414 Glycosyltransferase family 6 834 0.2025 SUB691 O-C-C-C-C-C-O 834 0.2025 PF01571 Aminomethyltransferase folate-binding domain 835 0.2024 SUB691 O-C-C-C-C-C-O 835 0.2024 PF03727 Hexokinase 836 0.2017 SUB309 O-H 836 0.2017 PF00153 Mitochondrial carrier protein 837 0.2014 SUB392 N(~C)(~C)(~C) 837 0.2014 PF03073 TspO/MBR family 838 0.2014 SUB300 N-H 838 0.2014 PF00520 Ion transport protein 839 0.2008 SUB371 C(~H)(:C) 839 0.2008 PF00001 7 transmembrane receptor (rhodopsin family), 840 0.2007 SUB413 S(~C)(~C) 840 0.2007 PF02773 S-adenosylmethionine synthetase, C-terminal domain 841 0.1999 SUB256 >= 1 aromatic ring 841 0.1999 PF00001 7 transmembrane receptor (rhodopsin family), 842 0.1996 SUB549 O-C-C:C 842 0.1996 PF00027 Cyclic nucleotide-binding domain 843 0.1983 SUB537 O=C-C-N 843 0.1983 PF00045 Hemopexin 844 0.1979 SUB17 >= 4 N 844 0.1979 PF00001 7 transmembrane receptor (rhodopsin family), 845 0.1979 SUB686 O=C-C-C-C-N 845 0.1979 PF08763 Voltage gated calcium channel IQ domain 846 0.1971 SUB228 >= 1 any ring size 8 846 0.1971 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 847 0.1966 SUB537 O=C-C-N 847 0.1966 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 848 0.1963 SUB605 C-O-C-C:C 848 0.1963 PF00105 Zinc finger, C4 type (two domains), 849 0.1963 SUB457 P(-O)(=O) 849 0.1963 PF02223 Thymidylate kinase 850 0.1953 SUB644 [#1]-C-C-N-[#1] 850 0.1953 PF00324 Amino acid permease 851 0.1949 SUB375 C(~H)(~H)(~H) 851 0.1949 PF00001 7 transmembrane receptor (rhodopsin family), 852 0.1943 SUB702 O-C-C-C-C-C(O)-C 852 0.1943 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 853 0.1941 SUB375 C(~H)(~H)(~H) 853 0.1941 PF06512 Sodium ion transport-associated 854 0.1934 SUB708 O=C-C-C-C-C(N)-C 854 0.1934 PF00092 von Willebrand factor type A domain 855 0.1933 SUB834 NC1C(N)CCCC1 855 0.1933 PF00175 Oxidoreductase NAD-binding domain 856 0.1925 SUB577 N=C-C:C-[#1] 856 0.1925 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 857 0.1923 SUB151 >= 2 any ring size 5 857 0.1923 PF02932 Neurotransmitter-gated ion-channel transmembrane region 858 0.1916 SUB499 O-C=C-C 858 0.1916 PF01477 PLAT/LH2 domain 859 0.1913 SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 859 0.1913 PF00520 Ion transport protein 860 0.1912 SUB582 O=C-C-C-O 860 0.1912 PF00069 Protein kinase domain 861 0.1908 SUB392 N(~C)(~C)(~C) 861 0.1908 PF00135 Carboxylesterase 862 0.1907 SUB605 C-O-C-C:C 862 0.1907 PF06512 Sodium ion transport-associated 863 0.1904 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 863 0.1904 PF00069 Protein kinase domain 864 0.1904 SUB762 Oc1c(O)cccc1 864 0.1904 PF00643 B-box zinc finger 865 0.1897 SUB692 O-C-C-C-C-C-N 865 0.1897 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 866 0.1878 SUB298 C-Br 866 0.1878 PF00001 7 transmembrane receptor (rhodopsin family), 867 0.1874 SUB339 C(~C)(~C)(~H)(~N) 867 0.1874 PF00258 Flavodoxin 868 0.1869 SUB660 O-C-C-N-C 868 0.1869 PF00614 Phospholipase D Active site motif 869 0.1861 SUB340 C(~C)(~C)(~H)(~O) 869 0.1861 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 870 0.1854 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 870 0.1854 PF00364 Biotin-requiring enzyme 871 0.1853 SUB375 C(~H)(~H)(~H) 871 0.1853 PF02932 Neurotransmitter-gated ion-channel transmembrane region 872 0.1851 SUB486 N:C:C:N 872 0.1851 PF00156 Phosphoribosyl transferase domain 873 0.1848 SUB13 >= 16 C 873 0.1848 PF00106 short chain dehydrogenase 874 0.1843 SUB613 N-C-O-C-C 874 0.1843 PF01712 Deoxynucleoside kinase 875 0.1841 SUB441 C(-C)(-O)(=O) 875 0.1841 PF02574 Homocysteine S-methyltransferase 876 0.1829 SUB287 C-O 876 0.1829 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 877 0.1828 SUB439 C(-C)(-N)(=N) 877 0.1828 PF00089 Trypsin 878 0.1822 SUB452 C(-N)(=O) 878 0.1822 PF01180 Dihydroorotate dehydrogenase 879 0.1820 SUB702 O-C-C-C-C-C(O)-C 879 0.1820 PF00088 Trefoil (P-type), domain 880 0.1820 SUB700 O-C-C-C-C-C(C)-C 880 0.1820 PF00520 Ion transport protein 881 0.1819 SUB433 C(-C)(-C)(=O) 881 0.1819 PF00091 Tubulin/FtsZ family, GTPase domain 882 0.1815 SUB572 [#1]-C-O-[#1] 882 0.1815 PF00342 Phosphoglucose isomerase 883 0.1814 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 883 0.1814 PF00664 ABC transporter transmembrane region 884 0.1813 SUB590 C-C:C-O-C 884 0.1813 PF08441 Integrin alpha 885 0.1812 SUB347 C(~C)(~H)(~O) 885 0.1812 PF00171 Aldehyde dehydrogenase family 886 0.1799 SUB440 C(-C)(-N)(=O) 886 0.1799 PF01471 Putative peptidoglycan binding domain 887 0.1781 SUB375 C(~H)(~H)(~H) 887 0.1781 PF01471 Putative peptidoglycan binding domain 888 0.1777 SUB444 C(-C)(=O) 888 0.1777 PF00233 3"5"-cyclic nucleotide phosphodiesterase 889 0.1774 SUB376 C(~N)(~N) 889 0.1774 PF00051 Kringle domain 890 0.1771 SUB339 C(~C)(~C)(~H)(~N) 890 0.1771 PF00017 SH2 domain 891 0.1768 SUB664 O-C-C-O-[#1] 891 0.1768 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 892 0.1761 SUB587 C-S-C-C-C 892 0.1761 PF00105 Zinc finger, C4 type (two domains), 893 0.1750 SUB345 C(~C)(~H) 893 0.1750 PF00060 Ligand-gated ion channel 894 0.1741 SUB144 >= 1 any ring size 5 894 0.1741 PF00233 3"5"-cyclic nucleotide phosphodiesterase 895 0.1740 SUB702 O-C-C-C-C-C(O)-C 895 0.1740 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 896 0.1734 SUB703 O-C-C-C-C-C-N-C 896 0.1734 PF03068 Protein-arginine deiminase (PAD), 897 0.1734 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 897 0.1734 PF00170 bZIP transcription factor 898 0.1733 SUB144 >= 1 any ring size 5 898 0.1733 PF00689 Cation transporting ATPase, C-terminus 899 0.1730 SUB338 C(~C)(~C)(~C)(~O) 899 0.1730 PF02161 Progesterone receptor 900 0.1729 SUB193 >= 3 any ring size 6 900 0.1729 PF00005 ABC transporter 901 0.1725 SUB760 Cc1c(Cl)cccc1 901 0.1725 PF00520 Ion transport protein 902 0.1720 SUB375 C(~H)(~H)(~H) 902 0.1720 PF00258 Flavodoxin 903 0.1717 SUB657 C-C-N-C-C 903 0.1717 PF00005 ABC transporter 904 0.1715 SUB602 N-C:C:C-N 904 0.1715 PF00106 short chain dehydrogenase 905 0.1714 SUB465 N-C-C=C 905 0.1714 PF03953 Tubulin C-terminal domain 906 0.1713 SUB359 C(~C)(:N) 906 0.1713 PF00001 7 transmembrane receptor (rhodopsin family), 907 0.1712 SUB682 O-C-C-C-C-O 907 0.1712 PF00017 SH2 domain 908 0.1701 SUB441 C(-C)(-O)(=O) 908 0.1701 PF07690 Major Facilitator Superfamily 909 0.1699 SUB145 >= 1 saturated or aromatic carbon-only ring size 5 909 0.1699 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 910 0.1697 SUB548 N-C:C-N 910 0.1697 PF00156 Phosphoribosyl transferase domain 911 0.1686 SUB389 C(:C)(:N)(:N) 911 0.1686 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 912 0.1684 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 912 0.1684 PF00204 DNA gyrase B 913 0.1677 SUB702 O-C-C-C-C-C(O)-C 913 0.1677 PF02806 Alpha amylase, C-terminal all-beta domain 914 0.1677 SUB461 C-C-C#C 914 0.1677 PF00104 Ligand-binding domain of nuclear hormone receptor 915 0.1676 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 915 0.1676 PF02785 Biotin carboxylase C-terminal domain 916 0.1673 SUB352 C(~C)(~N) 916 0.1673 PF00209 Sodium:neurotransmitter symporter family 917 0.1661 SUB706 O=C-C-C-C-C(O)-C 917 0.1661 PF00067 Cytochrome P450 918 0.1661 SUB457 P(-O)(=O) 918 0.1661 PF00074 Pancreatic ribonuclease 919 0.1659 SUB295 C-Cl 919 0.1659 PF00690 Cation transporter/ATPase, N-terminus 920 0.1645 SUB699 O-C-C-C-C-C-C-C 920 0.1645 PF02743 Cache domain 921 0.1640 SUB285 C-C 921 0.1640 PF02932 Neurotransmitter-gated ion-channel transmembrane region 922 0.1639 SUB336 C(~C)(~C)(~C)(~H) 922 0.1639 PF00520 Ion transport protein 923 0.1617 SUB840 CC1CC(C)CC1 923 0.1617 PF00104 Ligand-binding domain of nuclear hormone receptor 924 0.1616 SUB494 O=C-C:C 924 0.1616 PF00071 Ras family 925 0.1616 SUB300 N-H 925 0.1616 PF00001 7 transmembrane receptor (rhodopsin family), 926 0.1615 SUB548 N-C:C-N 926 0.1615 PF00962 Adenosine/AMP deaminase 927 0.1615 SUB759 Cc1c(N)cccc1 927 0.1615 PF00001 7 transmembrane receptor (rhodopsin family), 928 0.1614 SUB193 >= 3 any ring size 6 928 0.1614 PF01471 Putative peptidoglycan binding domain 929 0.1611 SUB392 N(~C)(~C)(~C) 929 0.1611 PF02932 Neurotransmitter-gated ion-channel transmembrane region 930 0.1608 SUB288 C-F 930 0.1608 PF01180 Dihydroorotate dehydrogenase 931 0.1604 SUB442 C(-C)(=C) 931 0.1604 PF00001 7 transmembrane receptor (rhodopsin family), 932 0.1599 SUB587 C-S-C-C-C 932 0.1599 PF02773 S-adenosylmethionine synthetase, C-terminal domain 933 0.1595 SUB625 O=C-C:C-N 933 0.1595 PF00001 7 transmembrane receptor (rhodopsin family), 934 0.1582 SUB300 N-H 934 0.1582 PF06464 DMAP1-binding Domain 935 0.1581 SUB675 N-C-N-C:C 935 0.1581 PF00520 Ion transport protein 936 0.1576 SUB354 C(~C)(~S) 936 0.1576 PF01471 Putative peptidoglycan binding domain 937 0.1576 SUB618 C-C-C-O-[#1] 937 0.1576 PF00571 CBS domain 938 0.1574 SUB668 C=C-C-O-[#1] 938 0.1574 PF00576 HIUase/Transthyretin family 939 0.1573 SUB408 O(~C)(~P) 939 0.1573 PF00069 Protein kinase domain 940 0.1571 SUB369 C(~H)(~S) 940 0.1571 PF08725 Integrin beta cytoplasmic domain 941 0.1570 SUB647 O=C-N-C-[#1] 941 0.1570 PF01007 Inward rectifier potassium channel 942 0.1569 SUB735 Cc1cc(C)ccc1 942 0.1569 PF00757 Furin-like cysteine rich region 943 0.1568 SUB389 C(:C)(:N)(:N) 943 0.1568 PF00069 Protein kinase domain 944 0.1564 SUB350 C(~C)(~H)(~S) 944 0.1564 PF00043 Glutathione S-transferase, C-terminal domain 945 0.1563 SUB640 O-C-C-C-O 945 0.1563 PF00390 Malic enzyme, N-terminal domain 946 0.1563 SUB699 O-C-C-C-C-C-C-C 946 0.1563 PF00664 ABC transporter transmembrane region 947 0.1561 SUB564 O-C-O-C 947 0.1561 PF07654 Immunoglobulin C1-set domain 948 0.1559 SUB10 >= 2 C 948 0.1559 PF00107 Zinc-binding dehydrogenase 949 0.1552 SUB300 N-H 949 0.1552 PF00051 Kringle domain 950 0.1545 SUB664 O-C-C-O-[#1] 950 0.1545 PF03949 Malic enzyme, NAD binding domain 951 0.1543 SUB575 O-C-C:C-C 951 0.1543 PF00027 Cyclic nucleotide-binding domain 952 0.1541 SUB685 O=C-C-C-C-C 952 0.1541 PF00001 7 transmembrane receptor (rhodopsin family), 953 0.1539 SUB194 >= 3 saturated or aromatic carbon-only ring size 6 953 0.1539 PF00005 ABC transporter 954 0.1538 SUB798 CC1CC(C)CCC1 954 0.1538 PF00105 Zinc finger, C4 type (two domains), 955 0.1538 SUB538 O=C-C-O 955 0.1538 PF00224 Pyruvate kinase, barrel domain 956 0.1536 SUB703 O-C-C-C-C-C-N-C 956 0.1536 PF08526 Protein-arginine deiminase (PAD), N-terminal domain 957 0.1532 SUB694 O=C-C-C-C-C-O 957 0.1532 PF00023 Ankyrin repeat 958 0.1532 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 958 0.1532 PF08070 DTHCT (NUC029), region 959 0.1531 SUB667 C=C-C-O-C 959 0.1531 PF00689 Cation transporting ATPase, C-terminus 960 0.1529 SUB412 P(~O)(~O) 960 0.1529 PF00074 Pancreatic ribonuclease 961 0.1529 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 961 0.1529 PF06512 Sodium ion transport-associated 962 0.1521 SUB336 C(~C)(~C)(~C)(~H) 962 0.1521 PF00089 Trypsin 963 0.1520 SUB663 O-C-C-O-C 963 0.1520 PF00501 AMP-binding enzyme 964 0.1516 SUB375 C(~H)(~H)(~H) 964 0.1516 PF01477 PLAT/LH2 domain 965 0.1516 SUB698 C-C-C-C-C-C(C)-C 965 0.1516 PF00413 Matrixin 966 0.1514 SUB419 C=N 966 0.1514 PF00001 7 transmembrane receptor (rhodopsin family), 967 0.1514 SUB533 S-C:C-[#1] 967 0.1514 PF01471 Putative peptidoglycan binding domain 968 0.1514 SUB712 C-C(C)(C)-C-C 968 0.1514 PF08763 Voltage gated calcium channel IQ domain 969 0.1512 SUB496 C-N-C:C 969 0.1512 PF00001 7 transmembrane receptor (rhodopsin family), 970 0.1511 SUB695 O=C-C-C-C-C=O 970 0.1511 PF02793 Hormone receptor domain 971 0.1510 SUB660 O-C-C-N-C 971 0.1510 PF00664 ABC transporter transmembrane region 972 0.1509 SUB373 C(~H)(:C)(:N) 972 0.1509 PF00282 Pyridoxal-dependent decarboxylase conserved domain 973 0.1507 SUB404 N(:C)(:C) 973 0.1507 PF00067 Cytochrome P450 974 0.1504 SUB287 C-O 974 0.1504 PF00145 C-5 cytosine-specific DNA methylase 975 0.1493 SUB557 C=C-C-C 975 0.1493 PF00067 Cytochrome P450 976 0.1490 SUB668 C=C-C-O-[#1] 976 0.1490 PF00106 short chain dehydrogenase 977 0.1488 SUB435 C(-C)(-H)(=C) 977 0.1488 PF00067 Cytochrome P450 978 0.1481 SUB664 O-C-C-O-[#1] 978 0.1481 PF03360 Glycosyltransferase family 43 979 0.1481 SUB568 O-C-C-O 979 0.1481 PF00728 Glycosyl hydrolase family 20, catalytic domain 980 0.1481 SUB582 O=C-C-C-O 980 0.1481 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 981 0.1475 SUB566 C:C-O-C 981 0.1475 PF08441 Integrin alpha 982 0.1473 SUB381 C(~O)(~O) 982 0.1473 PF03171 2OG-Fe(II), oxygenase superfamily 983 0.1473 SUB286 C-N 983 0.1473 PF00001 7 transmembrane receptor (rhodopsin family), 984 0.1468 SUB533 S-C:C-[#1] 984 0.1468 PF08403 Amino acid permease N-terminal 985 0.1468 SUB594 N-C-C-C-N 985 0.1468 PF01564 Spermine/spermidine synthase 986 0.1468 SUB703 O-C-C-C-C-C-N-C 986 0.1468 PF00571 CBS domain 987 0.1462 SUB629 C-N-C-C:C 987 0.1462 PF00452 Apoptosis regulator proteins, Bcl-2 family 988 0.1461 SUB300 N-H 988 0.1461 PF01426 BAH domain 989 0.1458 SUB802 CC1CC(Cl)CCC1 989 0.1458 PF02932 Neurotransmitter-gated ion-channel transmembrane region 990 0.1451 SUB620 O-C-C=C-C 990 0.1451 PF00822 PMP-22/EMP/MP20/Claudin family 991 0.1446 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 991 0.1446 PF00001 7 transmembrane receptor (rhodopsin family), 992 0.1446 SUB461 C-C-C#C 992 0.1446 PF00105 Zinc finger, C4 type (two domains), 993 0.1439 SUB375 C(~H)(~H)(~H) 993 0.1439 PF00557 Metallopeptidase family M24 994 0.1438 SUB618 C-C-C-O-[#1] 994 0.1438 PF00071 Ras family 995 0.1432 SUB463 O-C-C=O 995 0.1432 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 996 0.1429 SUB444 C(-C)(=O) 996 0.1429 PF00045 Hemopexin 997 0.1429 SUB688 O=C-C-C-C=O 997 0.1429 PF00152 tRNA synthetases class II (D, K and N), 998 0.1429 SUB578 C:C-N-C:C 998 0.1429 PF00042 Globin 999 0.1419 SUB664 O-C-C-O-[#1] 999 0.1419 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 1000 0.1416 SUB440 C(-C)(-N)(=O) 1000 0.1416 PF00056 lactate/malate dehydrogenase, NAD binding domain 1001 0.1411 SUB357 C(~C)(:C)(:C) 1001 0.1411 PF02159 Oestrogen receptor 1002 0.1409 SUB360 C(~C)(:N)(:N) 1002 0.1409 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 1003 0.1408 SUB608 N-C-C-C:C 1003 0.1408 PF00001 7 transmembrane receptor (rhodopsin family), 1004 0.1407 SUB543 O-C:C-[#1] 1004 0.1407 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1005 0.1406 SUB261 >= 3 hetero-aromatic rings 1005 0.1406 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 1006 0.1404 SUB285 C-C 1006 0.1404 PF02898 Nitric oxide synthase, oxygenase domain 1007 0.1404 SUB337 C(~C)(~C)(~C)(~N) 1007 0.1404 PF00001 7 transmembrane receptor (rhodopsin family), 1008 0.1404 SUB419 C=N 1008 0.1404 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1009 0.1401 SUB672 O=C-C=C-C 1009 0.1401 PF03098 Animal haem peroxidase 1010 0.1399 SUB682 O-C-C-C-C-O 1010 0.1399 PF00478 IMP dehydrogenase / GMP reductase domain 1011 0.1398 SUB598 O=C-C-C:C 1011 0.1398 PF03098 Animal haem peroxidase 1012 0.1395 SUB583 C-C-C-C-C 1012 0.1395 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1013 0.1392 SUB39 >= 2 Cl 1013 0.1392 PF00067 Cytochrome P450 1014 0.1391 SUB582 O=C-C-C-O 1014 0.1391 PF00454 Phosphatidylinositol 3- and 4-kinase 1015 0.1386 SUB771 Nc1c(N)cccc1 1015 0.1386 PF00175 Oxidoreductase NAD-binding domain 1016 0.1386 SUB621 C:C-O-C-C 1016 0.1386 PF01030 Receptor L domain 1017 0.1378 SUB466 O=S-C-C 1017 0.1378 PF00690 Cation transporter/ATPase, N-terminus 1018 0.1371 SUB644 [#1]-C-C-N-[#1] 1018 0.1371 PF00209 Sodium:neurotransmitter symporter family 1019 0.1365 SUB646 O=C-N-C-C 1019 0.1365 PF00005 ABC transporter 1020 0.1365 SUB696 O=C-C-C-C-C-N 1020 0.1365 PF00490 Delta-aminolevulinic acid dehydratase 1021 0.1359 SUB389 C(:C)(:N)(:N) 1021 0.1359 PF02770 Acyl-CoA dehydrogenase, middle domain 1022 0.1358 SUB643 O-C-C-C=O 1022 0.1358 PF00271 Helicase conserved C-terminal domain 1023 0.1353 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 1023 0.1353 PF00211 Adenylate and Guanylate cyclase catalytic domain 1024 0.1349 SUB457 P(-O)(=O) 1024 0.1349 PF00018 SH3 domain 1025 0.1344 SUB598 O=C-C-C:C 1025 0.1344 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 1026 0.1339 SUB625 O=C-C:C-N 1026 0.1339 PF01467 Cytidylyltransferase 1027 0.1324 SUB597 N=C-N-C-C 1027 0.1324 PF01048 Phosphorylase superfamily 1028 0.1322 SUB20 >= 2 O 1028 0.1322 PF00625 Guanylate kinase 1029 0.1319 SUB417 C=C 1029 0.1319 PF00001 7 transmembrane receptor (rhodopsin family), 1030 0.1313 SUB529 [#1]-N-C-[#1] 1030 0.1313 PF00089 Trypsin 1031 0.1313 SUB426 P=O 1031 0.1313 PF00018 SH3 domain 1032 0.1313 SUB295 C-Cl 1032 0.1313 PF00689 Cation transporting ATPase, C-terminus 1033 0.1312 SUB1 >= 4 H 1033 0.1312 PF00248 Aldo/keto reductase family 1034 0.1306 SUB256 >= 1 aromatic ring 1034 0.1306 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1035 0.1305 SUB376 C(~N)(~N) 1035 0.1305 PF00303 Thymidylate synthase 1036 0.1301 SUB398 N(~C)(:C)(:C) 1036 0.1301 PF00069 Protein kinase domain 1037 0.1300 SUB537 O=C-C-N 1037 0.1300 PF00133 tRNA synthetases class I (I, L, M and V), 1038 0.1293 SUB459 S(-O)(=O) 1038 0.1293 PF00520 Ion transport protein 1039 0.1293 SUB338 C(~C)(~C)(~C)(~O) 1039 0.1293 PF08384 Pro-opiomelanocortin, N-terminal region 1040 0.1292 SUB629 C-N-C-C:C 1040 0.1292 PF00104 Ligand-binding domain of nuclear hormone receptor 1041 0.1290 SUB21 >= 4 O 1041 0.1290 PF00390 Malic enzyme, N-terminal domain 1042 0.1286 SUB568 O-C-C-O 1042 0.1286 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 1043 0.1285 SUB620 O-C-C=C-C 1043 0.1285 PF00001 7 transmembrane receptor (rhodopsin family), 1044 0.1285 SUB618 C-C-C-O-[#1] 1044 0.1285 PF02806 Alpha amylase, C-terminal all-beta domain 1045 0.1284 SUB657 C-C-N-C-C 1045 0.1284 PF00989 PAS fold 1046 0.1282 SUB713 C-C(C)-C(C)-C 1046 0.1282 PF00067 Cytochrome P450 1047 0.1280 SUB345 C(~C)(~H) 1047 0.1280 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1048 0.1279 SUB677 N#C-C-C-C 1048 0.1279 PF00105 Zinc finger, C4 type (two domains), 1049 0.1277 SUB712 C-C(C)(C)-C-C 1049 0.1277 PF00067 Cytochrome P450 1050 0.1274 SUB578 C:C-N-C:C 1050 0.1274 PF00282 Pyridoxal-dependent decarboxylase conserved domain 1051 0.1273 SUB692 O-C-C-C-C-C-N 1051 0.1273 PF00927 Transglutaminase family, C-terminal ig like domain 1052 0.1271 SUB681 O-C-C-C-C-C 1052 0.1271 PF08763 Voltage gated calcium channel IQ domain 1053 0.1270 SUB633 C-C-O-C:C 1053 0.1270 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1054 0.1270 SUB603 O=C-C-N-C 1054 0.1270 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 1055 0.1269 SUB450 C(-N)(=C) 1055 0.1269 PF03098 Animal haem peroxidase 1056 0.1269 SUB378 C(~N)(:C)(:C) 1056 0.1269 PF00229 TNF(Tumour Necrosis Factor), family 1057 0.1268 SUB144 >= 1 any ring size 5 1057 0.1268 PF00001 7 transmembrane receptor (rhodopsin family), 1058 0.1266 SUB441 C(-C)(-O)(=O) 1058 0.1266 PF00104 Ligand-binding domain of nuclear hormone receptor 1059 0.1265 SUB189 >= 2 saturated or aromatic heteroatom-containing ring size 6 1059 0.1265 PF00001 7 transmembrane receptor (rhodopsin family), 1060 0.1263 SUB599 Cl-C:C:C-C 1060 0.1263 PF03073 TspO/MBR family 1061 0.1260 SUB494 O=C-C:C 1061 0.1260 PF00018 SH3 domain 1062 0.1258 SUB688 O=C-C-C-C=O 1062 0.1258 PF01336 OB-fold nucleic acid binding domain 1063 0.1256 SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 1063 0.1256 PF06387 D1 dopamine receptor-interacting protein (calcyon), 1064 0.1249 SUB595 C-O-C-C=C 1064 0.1249 PF00689 Cation transporting ATPase, C-terminus 1065 0.1247 SUB375 C(~H)(~H)(~H) 1065 0.1247 PF00667 FAD binding domain 1066 0.1246 SUB570 N-C-C-N 1066 0.1246 PF03073 TspO/MBR family 1067 0.1244 SUB144 >= 1 any ring size 5 1067 0.1244 PF00690 Cation transporter/ATPase, N-terminus 1068 0.1235 SUB567 O-C-C-N 1068 0.1235 PF00001 7 transmembrane receptor (rhodopsin family), 1069 0.1232 SUB700 O-C-C-C-C-C(C)-C 1069 0.1232 PF00069 Protein kinase domain 1070 0.1231 SUB401 N(~H)(:C)(:C) 1070 0.1231 PF00001 7 transmembrane receptor (rhodopsin family), 1071 0.1230 SUB640 O-C-C-C-O 1071 0.1230 PF03953 Tubulin C-terminal domain 1072 0.1226 SUB284 C-H 1072 0.1226 PF00107 Zinc-binding dehydrogenase 1073 0.1224 SUB19 >= 1 O 1073 0.1224 PF01180 Dihydroorotate dehydrogenase 1074 0.1221 SUB503 N-C=C-[#1] 1074 0.1221 PF03098 Animal haem peroxidase 1075 0.1220 SUB624 O=C-C:C-C 1075 0.1220 PF00464 Serine hydroxymethyltransferase 1076 0.1210 SUB697 C-C-C-C-C-C-C-C 1076 0.1210 PF00001 7 transmembrane receptor (rhodopsin family), 1077 0.1191 SUB618 C-C-C-O-[#1] 1077 0.1191 PF01841 Transglutaminase-like superfamily 1078 0.1189 SUB309 O-H 1078 0.1189 PF01063 Aminotransferase class IV 1079 0.1187 SUB675 N-C-N-C:C 1079 0.1187 PF02196 Raf-like Ras-binding domain 1080 0.1185 SUB646 O=C-N-C-C 1080 0.1185 PF07686 Immunoglobulin V-set domain 1081 0.1184 SUB466 O=S-C-C 1081 0.1184 PF00689 Cation transporting ATPase, C-terminus 1082 0.1184 SUB572 [#1]-C-O-[#1] 1082 0.1184 PF02806 Alpha amylase, C-terminal all-beta domain 1083 0.1184 SUB180 >= 1 saturated or aromatic carbon-only ring size 6 1083 0.1184 PF00520 Ion transport protein 1084 0.1183 SUB339 C(~C)(~C)(~H)(~N) 1084 0.1183 PF00018 SH3 domain 1085 0.1182 SUB529 [#1]-N-C-[#1] 1085 0.1182 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 1086 0.1182 SUB517 [#1]-C=C-[#1] 1086 0.1182 PF00069 Protein kinase domain 1087 0.1181 SUB488 N-C=N-C 1087 0.1181 PF00069 Protein kinase domain 1088 0.1173 SUB354 C(~C)(~S) 1088 0.1173 PF00045 Hemopexin 1089 0.1172 SUB691 O-C-C-C-C-C-O 1089 0.1172 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 1090 0.1162 SUB616 N-C-C-O-C 1090 0.1162 PF01401 Angiotensin-converting enzyme 1091 0.1159 SUB350 C(~C)(~H)(~S) 1091 0.1159 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 1092 0.1157 SUB421 C=O 1092 0.1157 PF00248 Aldo/keto reductase family 1093 0.1155 SUB641 C=C-C-C-C 1093 0.1155 PF00067 Cytochrome P450 1094 0.1155 SUB629 C-N-C-C:C 1094 0.1155 PF00225 Kinesin motor domain 1095 0.1148 SUB369 C(~H)(~S) 1095 0.1148 PF02798 Glutathione S-transferase, N-terminal domain 1096 0.1148 SUB335 C(~C)(~C)(~C)(~C) 1096 0.1148 PF03953 Tubulin C-terminal domain 1097 0.1147 SUB771 Nc1c(N)cccc1 1097 0.1147 PF01122 Eukaryotic cobalamin-binding protein 1098 0.1145 SUB712 C-C(C)(C)-C-C 1098 0.1145 PF00520 Ion transport protein 1099 0.1137 SUB345 C(~C)(~H) 1099 0.1137 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1100 0.1137 SUB697 C-C-C-C-C-C-C-C 1100 0.1137 PF00432 Prenyltransferase and squalene oxidase repeat 1101 0.1132 SUB381 C(~O)(~O) 1101 0.1132 PF00273 Serum albumin family 1102 0.1130 SUB573 N:C:N:C 1102 0.1130 PF00478 IMP dehydrogenase / GMP reductase domain 1103 0.1128 SUB133 >= 1 saturated or aromatic heteroatom-containing ring size 4 1103 0.1128 PF00854 POT family 1104 0.1126 SUB505 N:C:N-C 1104 0.1126 PF00478 IMP dehydrogenase / GMP reductase domain 1105 0.1123 SUB286 C-N 1105 0.1123 PF00209 Sodium:neurotransmitter symporter family 1106 0.1122 SUB622 N-C:C:C:N 1106 0.1122 PF00107 Zinc-binding dehydrogenase 1107 0.1122 SUB694 O=C-C-C-C-C-O 1107 0.1122 PF00324 Amino acid permease 1108 0.1121 SUB576 O-C-C:C-O 1108 0.1121 PF00171 Aldehyde dehydrogenase family 1109 0.1119 SUB32 >= 2 P 1109 0.1119 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 1110 0.1119 SUB644 [#1]-C-C-N-[#1] 1110 0.1119 PF01536 Adenosylmethionine decarboxylase 1111 0.1117 SUB537 O=C-C-N 1111 0.1117 PF00152 tRNA synthetases class II (D, K and N), 1112 0.1100 SUB586 C-C:C-N-C 1112 0.1100 PF00001 7 transmembrane receptor (rhodopsin family), 1113 0.1099 SUB537 O=C-C-N 1113 0.1099 PF06021 Aralkyl acyl-CoA:amino acid N-acyltransferase 1114 0.1099 SUB622 N-C:C:C:N 1114 0.1099 PF00005 ABC transporter 1115 0.1098 SUB242 >= 1 any ring size 9 1115 0.1098 PF00069 Protein kinase domain 1116 0.1097 SUB642 O-C-C-C=C 1116 0.1097 PF00001 7 transmembrane receptor (rhodopsin family), 1117 0.1097 SUB407 O(~C)(~H) 1117 0.1097 PF03949 Malic enzyme, NAD binding domain 1118 0.1093 SUB358 C(~C)(:C)(:N) 1118 0.1093 PF00042 Globin 1119 0.1085 SUB708 O=C-C-C-C-C(N)-C 1119 0.1085 PF08669 Glycine cleavage T-protein C-terminal barrel domain 1120 0.1084 SUB632 O-C:C-O-[#1] 1120 0.1084 PF01596 O-methyltransferase 1121 0.1080 SUB664 O-C-C-O-[#1] 1121 0.1080 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 1122 0.1072 SUB730 Nc1ccc(Cl)cc1 1122 0.1072 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1123 0.1072 SUB375 C(~H)(~H)(~H) 1123 0.1072 PF00045 Hemopexin 1124 0.1071 SUB646 O=C-N-C-C 1124 0.1071 PF00079 Serpin (serine protease inhibitor), 1125 0.1070 SUB376 C(~N)(~N) 1125 0.1070 PF00175 Oxidoreductase NAD-binding domain 1126 0.1067 SUB200 >= 4 any ring size 6 1126 0.1067 PF00357 Integrin alpha cytoplasmic region 1127 0.1065 SUB375 C(~H)(~H)(~H) 1127 0.1065 PF08674 Acetylcholinesterase tetramerisation domain 1128 0.1064 SUB589 O=C-C-C=O 1128 0.1064 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1129 0.1062 SUB762 Oc1c(O)cccc1 1129 0.1062 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1130 0.1055 SUB453 C(-O)(=O) 1130 0.1055 PF01063 Aminotransferase class IV 1131 0.1054 SUB309 O-H 1131 0.1054 PF03098 Animal haem peroxidase 1132 0.1053 SUB691 O-C-C-C-C-C-O 1132 0.1053 PF02525 Flavodoxin-like fold 1133 0.1052 SUB692 O-C-C-C-C-C-N 1133 0.1052 PF00074 Pancreatic ribonuclease 1134 0.1049 SUB602 N-C:C:C-N 1134 0.1049 PF00175 Oxidoreductase NAD-binding domain 1135 0.1046 SUB560 O-C-N-[#1] 1135 0.1046 PF00001 7 transmembrane receptor (rhodopsin family), 1136 0.1040 SUB804 OC1CC(O)CCC1 1136 0.1040 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1137 0.1040 SUB17 >= 4 N 1137 0.1040 PF00005 ABC transporter 1138 0.1038 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 1138 0.1038 PF00106 short chain dehydrogenase 1139 0.1033 SUB421 C=O 1139 0.1033 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1140 0.1025 SUB703 O-C-C-C-C-C-N-C 1140 0.1025 PF02223 Thymidylate kinase 1141 0.1025 SUB660 O-C-C-N-C 1141 0.1025 PF00755 Choline/Carnitine o-acyltransferase 1142 0.1023 SUB600 [#1]-C-C=C-[#1] 1142 0.1023 PF00001 7 transmembrane receptor (rhodopsin family), 1143 0.1022 SUB295 C-Cl 1143 0.1022 PF02254 TrkA-N domain 1144 0.1021 SUB31 >= 1 P 1144 0.1021 PF00018 SH3 domain 1145 0.1016 SUB375 C(~H)(~H)(~H) 1145 0.1016 PF00173 Cytochrome b5-like Heme/Steroid binding domain 1146 0.1013 SUB151 >= 2 any ring size 5 1146 0.1013 PF00364 Biotin-requiring enzyme 1147 0.1009 SUB640 O-C-C-C-O 1147 0.1009 PF00084 Sushi domain (SCR repeat), 1148 0.1009 SUB440 C(-C)(-N)(=O) 1148 0.1009 PF01841 Transglutaminase-like superfamily 1149 0.1006 SUB656 O-C-C-C:C 1149 0.1006 PF00027 Cyclic nucleotide-binding domain 1150 0.1006 SUB783 OC1CCC(O)CC1 1150 0.1006 PF00079 Serpin (serine protease inhibitor), 1151 0.1005 SUB709 C-C(C)-C-C 1151 0.1005 PF00520 Ion transport protein 1152 0.1005 SUB674 O=C-C=C-N 1152 0.1005 PF08669 Glycine cleavage T-protein C-terminal barrel domain 1153 0.1001 SUB365 C(~F)(:C) 1153 0.1001 PF00493 MCM2/3/5 family 1154 0.0996 SUB412 P(~O)(~O) 1154 0.0996 PF00017 SH2 domain 1155 0.0995 SUB587 C-S-C-C-C 1155 0.0995 PF00438 S-adenosylmethionine synthetase, N-terminal domain 1156 0.0994 SUB389 C(:C)(:N)(:N) 1156 0.0994 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 1157 0.0994 SUB566 C:C-O-C 1157 0.0994 PF00664 ABC transporter transmembrane region 1158 0.0993 SUB381 C(~O)(~O) 1158 0.0993 PF00128 Alpha amylase, catalytic domain 1159 0.0985 SUB704 O-C-C-C-C-C(N)-C 1159 0.0985 PF00291 Pyridoxal-phosphate dependent enzyme 1160 0.0981 SUB38 >= 1 Cl 1160 0.0981 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1161 0.0979 SUB432 C(-C)(-C)(=N) 1161 0.0979 PF00069 Protein kinase domain 1162 0.0978 SUB439 C(-C)(-N)(=N) 1162 0.0978 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1163 0.0974 SUB339 C(~C)(~C)(~H)(~N) 1163 0.0974 PF02798 Glutathione S-transferase, N-terminal domain 1164 0.0970 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 1164 0.0970 PF00521 DNA gyrase/topoisomerase IV, subunit A 1165 0.0966 SUB381 C(~O)(~O) 1165 0.0966 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1166 0.0965 SUB375 C(~H)(~H)(~H) 1166 0.0965 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1167 0.0965 SUB387 C(:C)(:C)(:N) 1167 0.0965 PF00005 ABC transporter 1168 0.0958 SUB451 C(-N)(=N) 1168 0.0958 PF00069 Protein kinase domain 1169 0.0957 SUB798 CC1CC(C)CCC1 1169 0.0957 PF00104 Ligand-binding domain of nuclear hormone receptor 1170 0.0953 SUB580 O=C-C-C-C 1170 0.0953 PF00106 short chain dehydrogenase 1171 0.0952 SUB2 >= 8 H 1171 0.0952 PF00089 Trypsin 1172 0.0951 SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 1172 0.0951 PF00001 7 transmembrane receptor (rhodopsin family), 1173 0.0950 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 1173 0.0950 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1174 0.0946 SUB444 C(-C)(=O) 1174 0.0946 PF01471 Putative peptidoglycan binding domain 1175 0.0945 SUB19 >= 1 O 1175 0.0945 PF00520 Ion transport protein 1176 0.0945 SUB394 N(~C)(~H) 1176 0.0945 PF02728 Copper amine oxidase, N3 domain 1177 0.0943 SUB660 O-C-C-N-C 1177 0.0943 PF00067 Cytochrome P450 1178 0.0943 SUB657 C-C-N-C-C 1178 0.0943 PF00001 7 transmembrane receptor (rhodopsin family), 1179 0.0943 SUB421 C=O 1179 0.0943 PF00266 Aminotransferase class-V 1180 0.0943 SUB421 C=O 1180 0.0943 PF00001 7 transmembrane receptor (rhodopsin family), 1181 0.0942 SUB682 O-C-C-C-C-O 1181 0.0942 PF00069 Protein kinase domain 1182 0.0939 SUB614 C-N-C-C-C 1182 0.0939 PF01007 Inward rectifier potassium channel 1183 0.0934 SUB582 O=C-C-C-O 1183 0.0934 PF00168 C2 domain 1184 0.0933 SUB388 C(:C)(:N) 1184 0.0933 PF00001 7 transmembrane receptor (rhodopsin family), 1185 0.0932 SUB393 N(~C)(~C)(~H) 1185 0.0932 PF00069 Protein kinase domain 1186 0.0932 SUB682 O-C-C-C-C-O 1186 0.0932 PF00343 Carbohydrate phosphorylase 1187 0.0932 SUB525 C-C=C-C 1187 0.0932 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1188 0.0932 SUB643 O-C-C-C=O 1188 0.0932 PF00454 Phosphatidylinositol 3- and 4-kinase 1189 0.0929 SUB595 C-O-C-C=C 1189 0.0929 PF00690 Cation transporter/ATPase, N-terminus 1190 0.0928 SUB537 O=C-C-N 1190 0.0928 PF01471 Putative peptidoglycan binding domain 1191 0.0928 SUB147 >= 1 saturated or aromatic heteroatom-containing ring size 5 1191 0.0928 PF00001 7 transmembrane receptor (rhodopsin family), 1192 0.0927 SUB639 O-C-C-C-N 1192 0.0927 PF01055 Glycosyl hydrolases family 31 1193 0.0926 SUB339 C(~C)(~C)(~H)(~N) 1193 0.0926 PF01336 OB-fold nucleic acid binding domain 1194 0.0924 SUB680 C-C-C-C-C-C 1194 0.0924 PF00273 Serum albumin family 1195 0.0920 SUB421 C=O 1195 0.0920 PF00051 Kringle domain 1196 0.0907 SUB613 N-C-O-C-C 1196 0.0907 PF00001 7 transmembrane receptor (rhodopsin family), 1197 0.0902 SUB522 C:N-C-[#1] 1197 0.0902 PF00104 Ligand-binding domain of nuclear hormone receptor 1198 0.0899 SUB492 C-N:C-[#1] 1198 0.0899 PF00045 Hemopexin 1199 0.0896 SUB243 >= 1 saturated or aromatic carbon-only ring size 9 1199 0.0896 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 1200 0.0891 SUB309 O-H 1200 0.0891 PF00303 Thymidylate synthase 1201 0.0889 SUB345 C(~C)(~H) 1201 0.0889 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 1202 0.0885 SUB25 >= 2 F 1202 0.0885 PF00520 Ion transport protein 1203 0.0884 SUB466 O=S-C-C 1203 0.0884 PF01471 Putative peptidoglycan binding domain 1204 0.0884 SUB21 >= 4 O 1204 0.0884 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 1205 0.0882 SUB618 C-C-C-O-[#1] 1205 0.0882 PF00868 Transglutaminase family 1206 0.0879 SUB407 O(~C)(~H) 1206 0.0879 PF00056 lactate/malate dehydrogenase, NAD binding domain 1207 0.0877 SUB642 O-C-C-C=C 1207 0.0877 PF00989 PAS fold 1208 0.0875 SUB288 C-F 1208 0.0875 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1209 0.0873 SUB137 >= 2 any ring size 4 1209 0.0873 PF00069 Protein kinase domain 1210 0.0869 SUB841 CC1CC(O)CC1 1210 0.0869 PF02155 Glucocorticoid receptor 1211 0.0866 SUB284 C-H 1211 0.0866 PF00497 Bacterial extracellular solute-binding proteins, family 3 1212 0.0864 SUB376 C(~N)(~N) 1212 0.0864 PF02867 Ribonucleotide reductase, barrel domain 1213 0.0863 SUB15 >= 1 N 1213 0.0863 PF00001 7 transmembrane receptor (rhodopsin family), 1214 0.0861 SUB674 O=C-C=C-N 1214 0.0861 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1215 0.0859 SUB638 O-C-C-C-C 1215 0.0859 PF00153 Mitochondrial carrier protein 1216 0.0854 SUB702 O-C-C-C-C-C(O)-C 1216 0.0854 PF00091 Tubulin/FtsZ family, GTPase domain 1217 0.0849 SUB441 C(-C)(-O)(=O) 1217 0.0849 PF00071 Ras family 1218 0.0848 SUB624 O=C-C:C-C 1218 0.0848 PF00571 CBS domain 1219 0.0845 SUB433 C(-C)(-C)(=O) 1219 0.0845 PF00089 Trypsin 1220 0.0845 SUB295 C-Cl 1220 0.0845 PF03493 Calcium-activated BK potassium channel alpha subunit 1221 0.0840 SUB380 C(~N)(:N) 1221 0.0840 PF01030 Receptor L domain 1222 0.0834 SUB366 C(~H)(~N) 1222 0.0834 PF02159 Oestrogen receptor 1223 0.0834 SUB381 C(~O)(~O) 1223 0.0834 PF00084 Sushi domain (SCR repeat), 1224 0.0832 SUB604 C-C:C:C-C 1224 0.0832 PF00209 Sodium:neurotransmitter symporter family 1225 0.0829 SUB200 >= 4 any ring size 6 1225 0.0829 PF00170 bZIP transcription factor 1226 0.0826 SUB602 N-C:C:C-N 1226 0.0826 PF00005 ABC transporter 1227 0.0825 SUB823 CC1C(Cl)CCCC1 1227 0.0825 PF00069 Protein kinase domain 1228 0.0814 SUB621 C:C-O-C-C 1228 0.0814 PF00757 Furin-like cysteine rich region 1229 0.0812 SUB488 N-C=N-C 1229 0.0812 PF00186 Dihydrofolate reductase 1230 0.0808 SUB712 C-C(C)(C)-C-C 1230 0.0808 PF08035 Opioids neuropeptide 1231 0.0805 SUB679 C-C-C=C-C 1231 0.0805 PF00305 Lipoxygenase 1232 0.0803 SUB674 O=C-C=C-N 1232 0.0803 PF02142 MGS-like domain 1233 0.0802 SUB654 O-C:C:C-O 1233 0.0802 PF00069 Protein kinase domain 1234 0.0801 SUB701 O-C-C-C-C-C-O-C 1234 0.0801 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1235 0.0800 SUB710 C-C(C)-C-C-C 1235 0.0800 PF02159 Oestrogen receptor 1236 0.0796 SUB436 C(-C)(-H)(=N) 1236 0.0796 PF00001 7 transmembrane receptor (rhodopsin family), 1237 0.0796 SUB862 CC1C(O)CCC1 1237 0.0796 PF02155 Glucocorticoid receptor 1238 0.0796 SUB582 O=C-C-C-O 1238 0.0796 PF00001 7 transmembrane receptor (rhodopsin family), 1239 0.0789 SUB673 O=C-C=C-[#1] 1239 0.0789 PF00107 Zinc-binding dehydrogenase 1240 0.0788 SUB377 C(~N)(:C) 1240 0.0788 PF00520 Ion transport protein 1241 0.0786 SUB683 O-C-C-C-C-N 1241 0.0786 PF00704 Glycosyl hydrolases family 18 1242 0.0785 SUB261 >= 3 hetero-aromatic rings 1242 0.0785 PF02770 Acyl-CoA dehydrogenase, middle domain 1243 0.0785 SUB16 >= 2 N 1243 0.0785 PF00324 Amino acid permease 1244 0.0770 SUB259 >= 2 hetero-aromatic rings 1244 0.0770 PF00001 7 transmembrane receptor (rhodopsin family), 1245 0.0768 SUB31 >= 1 P 1245 0.0768 PF00017 SH2 domain 1246 0.0760 SUB664 O-C-C-O-[#1] 1246 0.0760 PF01712 Deoxynucleoside kinase 1247 0.0760 SUB499 O-C=C-C 1247 0.0760 PF00001 7 transmembrane receptor (rhodopsin family), 1248 0.0756 SUB517 [#1]-C=C-[#1] 1248 0.0756 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1249 0.0756 SUB406 O(~C)(~C) 1249 0.0756 PF00337 Galactoside-binding lectin 1250 0.0755 SUB381 C(~O)(~O) 1250 0.0755 PF00105 Zinc finger, C4 type (two domains), 1251 0.0753 SUB446 C(-H)(-N)(=C) 1251 0.0753 PF08240 Alcohol dehydrogenase GroES-like domain 1252 0.0750 SUB380 C(~N)(:N) 1252 0.0750 PF00069 Protein kinase domain 1253 0.0747 SUB572 [#1]-C-O-[#1] 1253 0.0747 PF07686 Immunoglobulin V-set domain 1254 0.0743 SUB711 C-C-C(C)-C-C 1254 0.0743 PF02159 Oestrogen receptor 1255 0.0739 SUB295 C-Cl 1255 0.0739 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1256 0.0735 SUB697 C-C-C-C-C-C-C-C 1256 0.0735 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 1257 0.0732 SUB288 C-F 1257 0.0732 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1258 0.0732 SUB683 O-C-C-C-C-N 1258 0.0732 PF07885 Ion channel 1259 0.0731 SUB335 C(~C)(~C)(~C)(~C) 1259 0.0731 PF08035 Opioids neuropeptide 1260 0.0727 SUB684 N-C-C-C-C-C 1260 0.0727 PF00001 7 transmembrane receptor (rhodopsin family), 1261 0.0726 SUB379 C(~N)(:C)(:N) 1261 0.0726 PF00069 Protein kinase domain 1262 0.0717 SUB643 O-C-C-C=O 1262 0.0717 PF00005 ABC transporter 1263 0.0717 SUB193 >= 3 any ring size 6 1263 0.0717 PF00017 SH2 domain 1264 0.0716 SUB618 C-C-C-O-[#1] 1264 0.0716 PF07654 Immunoglobulin C1-set domain 1265 0.0715 SUB619 C:C-C-C:C 1265 0.0715 PF06512 Sodium ion transport-associated 1266 0.0713 SUB644 [#1]-C-C-N-[#1] 1266 0.0713 PF02166 Androgen receptor 1267 0.0711 SUB353 C(~C)(~O) 1267 0.0711 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1268 0.0710 SUB407 O(~C)(~H) 1268 0.0710 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 1269 0.0707 SUB340 C(~C)(~C)(~H)(~O) 1269 0.0707 PF00229 TNF(Tumour Necrosis Factor), family 1270 0.0707 SUB32 >= 2 P 1270 0.0707 PF00056 lactate/malate dehydrogenase, NAD binding domain 1271 0.0703 SUB431 C(-C)(-C)(=C) 1271 0.0703 PF00067 Cytochrome P450 1272 0.0703 SUB529 [#1]-N-C-[#1] 1272 0.0703 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 1273 0.0702 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 1273 0.0702 PF01471 Putative peptidoglycan binding domain 1274 0.0702 SUB4 >= 32 H 1274 0.0702 PF00520 Ion transport protein 1275 0.0701 SUB633 C-C-O-C:C 1275 0.0701 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 1276 0.0700 SUB780 CC1CCC(N)CC1 1276 0.0700 PF00001 7 transmembrane receptor (rhodopsin family), 1277 0.0697 SUB200 >= 4 any ring size 6 1277 0.0697 PF00043 Glutathione S-transferase, C-terminal domain 1278 0.0696 SUB647 O=C-N-C-[#1] 1278 0.0696 PF00551 Formyl transferase 1279 0.0691 SUB695 O=C-C-C-C-C=O 1279 0.0691 PF00749 tRNA synthetases class I (E and Q), , catalytic domain 1280 0.0682 SUB651 O=C-N-C=O 1280 0.0682 PF00001 7 transmembrane receptor (rhodopsin family), 1281 0.0681 SUB581 O=C-C-C-N 1281 0.0681 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1282 0.0676 SUB600 [#1]-C-C=C-[#1] 1282 0.0676 PF03098 Animal haem peroxidase 1283 0.0671 SUB453 C(-O)(=O) 1283 0.0671 PF00092 von Willebrand factor type A domain 1284 0.0668 SUB435 C(-C)(-H)(=C) 1284 0.0668 PF03098 Animal haem peroxidase 1285 0.0668 SUB646 O=C-N-C-C 1285 0.0668 PF01477 PLAT/LH2 domain 1286 0.0667 SUB453 C(-O)(=O) 1286 0.0667 PF01433 Peptidase family M1 1287 0.0665 SUB21 >= 4 O 1287 0.0665 PF00005 ABC transporter 1288 0.0664 SUB426 P=O 1288 0.0664 PF00074 Pancreatic ribonuclease 1289 0.0664 SUB346 C(~C)(~H)(~N) 1289 0.0664 PF00005 ABC transporter 1290 0.0663 SUB431 C(-C)(-C)(=C) 1290 0.0663 PF00305 Lipoxygenase 1291 0.0663 SUB603 O=C-C-N-C 1291 0.0663 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1292 0.0662 SUB394 N(~C)(~H) 1292 0.0662 PF02727 Copper amine oxidase, N2 domain 1293 0.0660 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 1293 0.0660 PF00001 7 transmembrane receptor (rhodopsin family), 1294 0.0659 SUB200 >= 4 any ring size 6 1294 0.0659 PF00001 7 transmembrane receptor (rhodopsin family), 1295 0.0659 SUB622 N-C:C:C:N 1295 0.0659 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 1296 0.0658 SUB261 >= 3 hetero-aromatic rings 1296 0.0658 PF00005 ABC transporter 1297 0.0658 SUB658 C-N-C:C-C 1297 0.0658 PF00001 7 transmembrane receptor (rhodopsin family), 1298 0.0655 SUB580 O=C-C-C-C 1298 0.0655 PF00067 Cytochrome P450 1299 0.0652 SUB720 Oc1ccc(O)cc1 1299 0.0652 PF00104 Ligand-binding domain of nuclear hormone receptor 1300 0.0650 SUB441 C(-C)(-O)(=O) 1300 0.0650 PF00153 Mitochondrial carrier protein 1301 0.0647 SUB394 N(~C)(~H) 1301 0.0647 PF06464 DMAP1-binding Domain 1302 0.0646 SUB690 O-C-C-C-C-C-C 1302 0.0646 PF00105 Zinc finger, C4 type (two domains), 1303 0.0644 SUB371 C(~H)(:C) 1303 0.0644 PF06512 Sodium ion transport-associated 1304 0.0644 SUB389 C(:C)(:N)(:N) 1304 0.0644 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 1305 0.0639 SUB357 C(~C)(:C)(:C) 1305 0.0639 PF00209 Sodium:neurotransmitter symporter family 1306 0.0638 SUB696 O=C-C-C-C-C-N 1306 0.0638 PF00491 Arginase family 1307 0.0638 SUB376 C(~N)(~N) 1307 0.0638 PF03477 ATP cone domain 1308 0.0636 SUB375 C(~H)(~H)(~H) 1308 0.0636 PF03098 Animal haem peroxidase 1309 0.0635 SUB457 P(-O)(=O) 1309 0.0635 PF01467 Cytidylyltransferase 1310 0.0633 SUB15 >= 1 N 1310 0.0633 PF00209 Sodium:neurotransmitter symporter family 1311 0.0632 SUB19 >= 1 O 1311 0.0632 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1312 0.0627 SUB691 O-C-C-C-C-C-O 1312 0.0627 PF01712 Deoxynucleoside kinase 1313 0.0626 SUB375 C(~H)(~H)(~H) 1313 0.0626 PF01180 Dihydroorotate dehydrogenase 1314 0.0625 SUB466 O=S-C-C 1314 0.0625 PF00664 ABC transporter transmembrane region 1315 0.0625 SUB633 C-C-O-C:C 1315 0.0625 PF01030 Receptor L domain 1316 0.0622 SUB386 C(:C)(:C)(:C) 1316 0.0622 PF00001 7 transmembrane receptor (rhodopsin family), 1317 0.0620 SUB698 C-C-C-C-C-C(C)-C 1317 0.0620 PF00092 von Willebrand factor type A domain 1318 0.0619 SUB390 C(:N)(:N) 1318 0.0619 PF00757 Furin-like cysteine rich region 1319 0.0619 SUB541 C-N-C-[#1] 1319 0.0619 PF00005 ABC transporter 1320 0.0614 SUB407 O(~C)(~H) 1320 0.0614 PF02770 Acyl-CoA dehydrogenase, middle domain 1321 0.0614 SUB214 >= 1 any ring size 7 1321 0.0614 PF00209 Sodium:neurotransmitter symporter family 1322 0.0610 SUB582 O=C-C-C-O 1322 0.0610 PF00291 Pyridoxal-phosphate dependent enzyme 1323 0.0609 SUB288 C-F 1323 0.0609 PF00248 Aldo/keto reductase family 1324 0.0607 SUB593 N-C-C-C-C 1324 0.0607 PF01593 Flavin containing amine oxidoreductase 1325 0.0607 SUB705 O=C-C-C-C-C-C-C 1325 0.0607 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 1326 0.0605 SUB546 N-C:C-C 1326 0.0605 PF00001 7 transmembrane receptor (rhodopsin family), 1327 0.0603 SUB309 O-H 1327 0.0603 PF01180 Dihydroorotate dehydrogenase 1328 0.0602 SUB368 C(~H)(~O)(~O) 1328 0.0602 PF00167 Fibroblast growth factor 1329 0.0597 SUB38 >= 1 Cl 1329 0.0597 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1330 0.0597 SUB572 [#1]-C-O-[#1] 1330 0.0597 PF05221 S-adenosyl-L-homocysteine hydrolase 1331 0.0597 SUB691 O-C-C-C-C-C-O 1331 0.0597 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 1332 0.0596 SUB757 Cc1c(O)cccc1 1332 0.0596 PF00005 ABC transporter 1333 0.0593 SUB315 O-P 1333 0.0593 PF03770 Inositol polyphosphate kinase 1334 0.0592 SUB453 C(-O)(=O) 1334 0.0592 PF01401 Angiotensin-converting enzyme 1335 0.0591 SUB594 N-C-C-C-N 1335 0.0591 PF00067 Cytochrome P450 1336 0.0590 SUB594 N-C-C-C-N 1336 0.0590 PF00026 Eukaryotic aspartyl protease 1337 0.0583 SUB686 O=C-C-C-C-N 1337 0.0583 PF00045 Hemopexin 1338 0.0578 SUB249 >= 1 any ring size 10 1338 0.0578 PF00168 C2 domain 1339 0.0574 SUB432 C(-C)(-C)(=N) 1339 0.0574 PF03073 TspO/MBR family 1340 0.0573 SUB683 O-C-C-C-C-N 1340 0.0573 PF00153 Mitochondrial carrier protein 1341 0.0572 SUB643 O-C-C-C=O 1341 0.0572 PF00091 Tubulin/FtsZ family, GTPase domain 1342 0.0570 SUB496 C-N-C:C 1342 0.0570 PF00702 haloacid dehalogenase-like hydrolase 1343 0.0569 SUB384 C(~S)(:C) 1343 0.0569 PF08403 Amino acid permease N-terminal 1344 0.0568 SUB407 O(~C)(~H) 1344 0.0568 PF00169 PH domain 1345 0.0568 SUB25 >= 2 F 1345 0.0568 PF00702 haloacid dehalogenase-like hydrolase 1346 0.0567 SUB664 O-C-C-O-[#1] 1346 0.0567 PF02770 Acyl-CoA dehydrogenase, middle domain 1347 0.0565 SUB738 Cc1cc(N)ccc1 1347 0.0565 PF00324 Amino acid permease 1348 0.0554 SUB299 C-I 1348 0.0554 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1349 0.0547 SUB441 C(-C)(-O)(=O) 1349 0.0547 PF03098 Animal haem peroxidase 1350 0.0545 SUB12 >= 8 C 1350 0.0545 PF06512 Sodium ion transport-associated 1351 0.0543 SUB735 Cc1cc(C)ccc1 1351 0.0543 PF00069 Protein kinase domain 1352 0.0539 SUB537 O=C-C-N 1352 0.0539 PF08444 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region 1353 0.0537 SUB288 C-F 1353 0.0537 PF07686 Immunoglobulin V-set domain 1354 0.0536 SUB658 C-N-C:C-C 1354 0.0536 PF00105 Zinc finger, C4 type (two domains), 1355 0.0536 SUB594 N-C-C-C-N 1355 0.0536 PF01048 Phosphorylase superfamily 1356 0.0534 SUB367 C(~H)(~O) 1356 0.0534 PF00520 Ion transport protein 1357 0.0532 SUB618 C-C-C-O-[#1] 1357 0.0532 PF00079 Serpin (serine protease inhibitor), 1358 0.0532 SUB688 O=C-C-C-C=O 1358 0.0532 PF00005 ABC transporter 1359 0.0531 SUB376 C(~N)(~N) 1359 0.0531 PF00317 Ribonucleotide reductase, all-alpha domain 1360 0.0527 SUB577 N=C-C:C-[#1] 1360 0.0527 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1361 0.0527 SUB642 O-C-C-C=C 1361 0.0527 PF00069 Protein kinase domain 1362 0.0523 SUB702 O-C-C-C-C-C(O)-C 1362 0.0523 PF03953 Tubulin C-terminal domain 1363 0.0522 SUB683 O-C-C-C-C-N 1363 0.0522 PF00171 Aldehyde dehydrogenase family 1364 0.0519 SUB550 N-C-C:C 1364 0.0519 PF00229 TNF(Tumour Necrosis Factor), family 1365 0.0518 SUB24 >= 1 F 1365 0.0518 PF01094 Receptor family ligand binding region 1366 0.0514 SUB692 O-C-C-C-C-C-N 1366 0.0514 PF00209 Sodium:neurotransmitter symporter family 1367 0.0510 SUB258 >= 2 aromatic rings 1367 0.0510 PF00069 Protein kinase domain 1368 0.0510 SUB339 C(~C)(~C)(~H)(~N) 1368 0.0510 PF00579 tRNA synthetases class I (W and Y), 1369 0.0509 SUB407 O(~C)(~H) 1369 0.0509 PF00105 Zinc finger, C4 type (two domains), 1370 0.0508 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 1370 0.0508 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1371 0.0508 SUB441 C(-C)(-O)(=O) 1371 0.0508 PF06021 Aralkyl acyl-CoA:amino acid N-acyltransferase 1372 0.0506 SUB21 >= 4 O 1372 0.0506 PF00153 Mitochondrial carrier protein 1373 0.0503 SUB507 C-C:N:C 1373 0.0503 PF00571 CBS domain 1374 0.0502 SUB390 C(:N)(:N) 1374 0.0502 PF01030 Receptor L domain 1375 0.0493 SUB711 C-C-C(C)-C-C 1375 0.0493 PF00305 Lipoxygenase 1376 0.0492 SUB295 C-Cl 1376 0.0492 PF00520 Ion transport protein 1377 0.0491 SUB738 Cc1cc(N)ccc1 1377 0.0491 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 1378 0.0491 SUB643 O-C-C-C=O 1378 0.0491 PF03953 Tubulin C-terminal domain 1379 0.0489 SUB366 C(~H)(~N) 1379 0.0489 PF00497 Bacterial extracellular solute-binding proteins, family 3 1380 0.0488 SUB697 C-C-C-C-C-C-C-C 1380 0.0488 PF00209 Sodium:neurotransmitter symporter family 1381 0.0487 SUB532 S-C:C-C 1381 0.0487 PF08403 Amino acid permease N-terminal 1382 0.0487 SUB515 O-N-C-C 1382 0.0487 PF00413 Matrixin 1383 0.0486 SUB376 C(~N)(~N) 1383 0.0486 PF01007 Inward rectifier potassium channel 1384 0.0483 SUB407 O(~C)(~H) 1384 0.0483 PF00343 Carbohydrate phosphorylase 1385 0.0474 SUB656 O-C-C-C:C 1385 0.0474 PF00001 7 transmembrane receptor (rhodopsin family), 1386 0.0474 SUB598 O=C-C-C:C 1386 0.0474 PF00464 Serine hydroxymethyltransferase 1387 0.0468 SUB346 C(~C)(~H)(~N) 1387 0.0468 PF00664 ABC transporter transmembrane region 1388 0.0466 SUB394 N(~C)(~H) 1388 0.0466 PF00520 Ion transport protein 1389 0.0463 SUB517 [#1]-C=C-[#1] 1389 0.0463 PF06512 Sodium ion transport-associated 1390 0.0463 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 1390 0.0463 PF00005 ABC transporter 1391 0.0462 SUB336 C(~C)(~C)(~C)(~H) 1391 0.0462 PF01471 Putative peptidoglycan binding domain 1392 0.0456 SUB575 O-C-C:C-C 1392 0.0456 PF00001 7 transmembrane receptor (rhodopsin family), 1393 0.0456 SUB638 O-C-C-C-C 1393 0.0456 PF00001 7 transmembrane receptor (rhodopsin family), 1394 0.0455 SUB158 >= 3 any ring size 5 1394 0.0455 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 1395 0.0455 SUB335 C(~C)(~C)(~C)(~C) 1395 0.0455 PF00067 Cytochrome P450 1396 0.0454 SUB602 N-C:C:C-N 1396 0.0454 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 1397 0.0453 SUB408 O(~C)(~P) 1397 0.0453 PF02223 Thymidylate kinase 1398 0.0453 SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 1398 0.0453 PF08246 Cathepsin propeptide inhibitor domain (I29), 1399 0.0448 SUB567 O-C-C-N 1399 0.0448 PF03199 Eukaryotic glutathione synthase 1400 0.0443 SUB463 O-C-C=O 1400 0.0443 PF00102 Protein-tyrosine phosphatase 1401 0.0443 SUB440 C(-C)(-N)(=O) 1401 0.0443 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1402 0.0441 SUB690 O-C-C-C-C-C-C 1402 0.0441 PF00413 Matrixin 1403 0.0440 SUB707 O=C-C-C-C-C(=O)-C 1403 0.0440 PF00001 7 transmembrane receptor (rhodopsin family), 1404 0.0440 SUB243 >= 1 saturated or aromatic carbon-only ring size 9 1404 0.0440 PF02155 Glucocorticoid receptor 1405 0.0437 SUB582 O=C-C-C-O 1405 0.0437 PF03953 Tubulin C-terminal domain 1406 0.0435 SUB261 >= 3 hetero-aromatic rings 1406 0.0435 PF00018 SH3 domain 1407 0.0434 SUB372 C(~H)(:C)(:C) 1407 0.0434 PF00209 Sodium:neurotransmitter symporter family 1408 0.0427 SUB712 C-C(C)(C)-C-C 1408 0.0427 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1409 0.0426 SUB338 C(~C)(~C)(~C)(~O) 1409 0.0426 PF00104 Ligand-binding domain of nuclear hormone receptor 1410 0.0425 SUB529 [#1]-N-C-[#1] 1410 0.0425 PF00069 Protein kinase domain 1411 0.0425 SUB646 O=C-N-C-C 1411 0.0425 PF00664 ABC transporter transmembrane region 1412 0.0424 SUB412 P(~O)(~O) 1412 0.0424 PF00018 SH3 domain 1413 0.0424 SUB536 O=C-C-C 1413 0.0424 PF00282 Pyridoxal-dependent decarboxylase conserved domain 1414 0.0416 SUB861 CC1C(C)CCC1 1414 0.0416 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 1415 0.0415 SUB677 N#C-C-C-C 1415 0.0415 PF00625 Guanylate kinase 1416 0.0410 SUB381 C(~O)(~O) 1416 0.0410 PF00067 Cytochrome P450 1417 0.0408 SUB722 Oc1ccc(N)cc1 1417 0.0408 PF07885 Ion channel 1418 0.0407 SUB620 O-C-C=C-C 1418 0.0407 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1419 0.0405 SUB629 C-N-C-C:C 1419 0.0405 PF00001 7 transmembrane receptor (rhodopsin family), 1420 0.0403 SUB699 O-C-C-C-C-C-C-C 1420 0.0403 PF08399 VWA N-terminal 1421 0.0401 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 1421 0.0401 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 1422 0.0401 SUB447 C(-H)(=C) 1422 0.0401 PF00067 Cytochrome P450 1423 0.0401 SUB394 N(~C)(~H) 1423 0.0401 PF00001 7 transmembrane receptor (rhodopsin family), 1424 0.0400 SUB629 C-N-C-C:C 1424 0.0400 PF00105 Zinc finger, C4 type (two domains), 1425 0.0398 SUB381 C(~O)(~O) 1425 0.0398 PF02887 Pyruvate kinase, alpha/beta domain 1426 0.0395 SUB622 N-C:C:C:N 1426 0.0395 PF00018 SH3 domain 1427 0.0395 SUB453 C(-O)(=O) 1427 0.0395 PF01180 Dihydroorotate dehydrogenase 1428 0.0389 SUB668 C=C-C-O-[#1] 1428 0.0389 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1429 0.0385 SUB491 C-C-C=C 1429 0.0385 PF00067 Cytochrome P450 1430 0.0384 SUB715 Cc1ccc(O)cc1 1430 0.0384 PF00001 7 transmembrane receptor (rhodopsin family), 1431 0.0381 SUB517 [#1]-C=C-[#1] 1431 0.0381 PF00105 Zinc finger, C4 type (two domains), 1432 0.0380 SUB682 O-C-C-C-C-O 1432 0.0380 PF00171 Aldehyde dehydrogenase family 1433 0.0378 SUB444 C(-C)(=O) 1433 0.0378 PF00001 7 transmembrane receptor (rhodopsin family), 1434 0.0378 SUB629 C-N-C-C:C 1434 0.0378 PF00702 haloacid dehalogenase-like hydrolase 1435 0.0377 SUB38 >= 1 Cl 1435 0.0377 PF00689 Cation transporting ATPase, C-terminus 1436 0.0369 SUB572 [#1]-C-O-[#1] 1436 0.0369 PF00005 ABC transporter 1437 0.0369 SUB473 C:N:C-C 1437 0.0369 PF00571 CBS domain 1438 0.0360 SUB586 C-C:C-N-C 1438 0.0360 PF00105 Zinc finger, C4 type (two domains), 1439 0.0355 SUB447 C(-H)(=C) 1439 0.0355 PF00001 7 transmembrane receptor (rhodopsin family), 1440 0.0351 SUB633 C-C-O-C:C 1440 0.0351 PF03765 CRAL/TRIO, N-terminus 1441 0.0347 SUB444 C(-C)(=O) 1441 0.0347 PF00105 Zinc finger, C4 type (two domains), 1442 0.0346 SUB640 O-C-C-C-O 1442 0.0346 PF00091 Tubulin/FtsZ family, GTPase domain 1443 0.0346 SUB354 C(~C)(~S) 1443 0.0346 PF00043 Glutathione S-transferase, C-terminal domain 1444 0.0343 SUB375 C(~H)(~H)(~H) 1444 0.0343 PF00702 haloacid dehalogenase-like hydrolase 1445 0.0336 SUB567 O-C-C-N 1445 0.0336 PF01063 Aminotransferase class IV 1446 0.0316 SUB251 >= 1 saturated or aromatic nitrogen-containing ring size 10 1446 0.0316 PF00001 7 transmembrane receptor (rhodopsin family), 1447 0.0316 SUB337 C(~C)(~C)(~C)(~N) 1447 0.0316 PF00431 CUB domain 1448 0.0314 SUB630 S-C:C:C-N 1448 0.0314 PF00001 7 transmembrane receptor (rhodopsin family), 1449 0.0311 SUB339 C(~C)(~C)(~H)(~N) 1449 0.0311 PF00520 Ion transport protein 1450 0.0307 SUB394 N(~C)(~H) 1450 0.0307 PF00209 Sodium:neurotransmitter symporter family 1451 0.0306 SUB407 O(~C)(~H) 1451 0.0306 PF00104 Ligand-binding domain of nuclear hormone receptor 1452 0.0306 SUB615 C-C-O-C-C 1452 0.0306 PF07645 Calcium-binding EGF domain 1453 0.0296 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 1453 0.0296 PF00180 Isocitrate/isopropylmalate dehydrogenase 1454 0.0296 SUB339 C(~C)(~C)(~H)(~N) 1454 0.0296 PF00375 Sodium:dicarboxylate symporter family 1455 0.0295 SUB672 O=C-C=C-C 1455 0.0295 PF00105 Zinc finger, C4 type (two domains), 1456 0.0294 SUB3 >= 16 H 1456 0.0294 PF00520 Ion transport protein 1457 0.0290 SUB524 N:C:C-C 1457 0.0290 PF00001 7 transmembrane receptor (rhodopsin family), 1458 0.0289 SUB545 O-C:C-O 1458 0.0289 PF07690 Major Facilitator Superfamily 1459 0.0288 SUB661 C-C=C-C-C 1459 0.0288 PF00305 Lipoxygenase 1460 0.0286 SUB38 >= 1 Cl 1460 0.0286 PF00043 Glutathione S-transferase, C-terminal domain 1461 0.0282 SUB505 N:C:N-C 1461 0.0282 PF01030 Receptor L domain 1462 0.0277 SUB609 C-C-C-C:C 1462 0.0277 PF00209 Sodium:neurotransmitter symporter family 1463 0.0277 SUB594 N-C-C-C-N 1463 0.0277 PF00005 ABC transporter 1464 0.0276 SUB186 >= 2 any ring size 6 1464 0.0276 PF00204 DNA gyrase B 1465 0.0276 SUB500 N-C:C:N 1465 0.0276 PF01048 Phosphorylase superfamily 1466 0.0276 SUB538 O=C-C-O 1466 0.0276 PF00102 Protein-tyrosine phosphatase 1467 0.0276 SUB595 C-O-C-C=C 1467 0.0276 PF00105 Zinc finger, C4 type (two domains), 1468 0.0270 SUB407 O(~C)(~H) 1468 0.0270 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 1469 0.0268 SUB4 >= 32 H 1469 0.0268 PF03765 CRAL/TRIO, N-terminus 1470 0.0265 SUB622 N-C:C:C:N 1470 0.0265 PF00017 SH2 domain 1471 0.0261 SUB407 O(~C)(~H) 1471 0.0261 PF02806 Alpha amylase, C-terminal all-beta domain 1472 0.0260 SUB342 C(~C)(~C)(~O) 1472 0.0260 PF02159 Oestrogen receptor 1473 0.0253 SUB505 N:C:N-C 1473 0.0253 PF00821 Phosphoenolpyruvate carboxykinase 1474 0.0249 SUB287 C-O 1474 0.0249 PF00060 Ligand-gated ion channel 1475 0.0247 SUB492 C-N:C-[#1] 1475 0.0247 PF02196 Raf-like Ras-binding domain 1476 0.0242 SUB342 C(~C)(~C)(~O) 1476 0.0242 PF00069 Protein kinase domain 1477 0.0242 SUB295 C-Cl 1477 0.0242 PF00084 Sushi domain (SCR repeat), 1478 0.0242 SUB19 >= 1 O 1478 0.0242 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1479 0.0239 SUB554 O=C-C=C 1479 0.0239 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1480 0.0232 SUB374 C(~H)(:N) 1480 0.0232 PF02196 Raf-like Ras-binding domain 1481 0.0230 SUB667 C=C-C-O-C 1481 0.0230 PF00105 Zinc finger, C4 type (two domains), 1482 0.0229 SUB432 C(-C)(-C)(=N) 1482 0.0229 PF00225 Kinesin motor domain 1483 0.0228 SUB647 O=C-N-C-[#1] 1483 0.0228 PF00664 ABC transporter transmembrane region 1484 0.0218 SUB692 O-C-C-C-C-C-N 1484 0.0218 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 1485 0.0214 SUB258 >= 2 aromatic rings 1485 0.0214 PF00067 Cytochrome P450 1486 0.0213 SUB17 >= 4 N 1486 0.0213 PF00069 Protein kinase domain 1487 0.0212 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 1487 0.0212 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 1488 0.0207 SUB757 Cc1c(O)cccc1 1488 0.0207 PF01023 S-100/ICaBP type calcium binding domain 1489 0.0205 SUB335 C(~C)(~C)(~C)(~C) 1489 0.0205 PF00976 Corticotropin ACTH domain 1490 0.0204 SUB699 O-C-C-C-C-C-C-C 1490 0.0204 PF00520 Ion transport protein 1491 0.0200 SUB339 C(~C)(~C)(~H)(~N) 1491 0.0200 PF00667 FAD binding domain 1492 0.0198 SUB581 O=C-C-C-N 1492 0.0198 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1493 0.0197 SUB567 O-C-C-N 1493 0.0197 PF02574 Homocysteine S-methyltransferase 1494 0.0196 SUB573 N:C:N:C 1494 0.0196 PF00757 Furin-like cysteine rich region 1495 0.0196 SUB739 Cc1cc(Cl)ccc1 1495 0.0196 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1496 0.0194 SUB696 O=C-C-C-C-C-N 1496 0.0194 PF08527 Protein-arginine deiminase (PAD), middle domain 1497 0.0193 SUB615 C-C-O-C-C 1497 0.0193 PF01030 Receptor L domain 1498 0.0193 SUB735 Cc1cc(C)ccc1 1498 0.0193 PF00104 Ligand-binding domain of nuclear hormone receptor 1499 0.0193 SUB834 NC1C(N)CCCC1 1499 0.0193 PF00001 7 transmembrane receptor (rhodopsin family), 1500 0.0193 SUB704 O-C-C-C-C-C(N)-C 1500 0.0193 PF00214 Calcitonin / CGRP / IAPP family 1501 0.0189 SUB394 N(~C)(~H) 1501 0.0189 PF01426 BAH domain 1502 0.0189 SUB366 C(~H)(~N) 1502 0.0189 PF03073 TspO/MBR family 1503 0.0185 SUB529 [#1]-N-C-[#1] 1503 0.0185 PF01490 Transmembrane amino acid transporter protein 1504 0.0185 SUB32 >= 2 P 1504 0.0185 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 1505 0.0183 SUB494 O=C-C:C 1505 0.0183 PF00001 7 transmembrane receptor (rhodopsin family), 1506 0.0183 SUB678 C-C=C-C:C 1506 0.0183 PF00209 Sodium:neurotransmitter symporter family 1507 0.0182 SUB334 C(~C)(~C)(~C) 1507 0.0182 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1508 0.0178 SUB452 C(-N)(=O) 1508 0.0178 PF00107 Zinc-binding dehydrogenase 1509 0.0177 SUB389 C(:C)(:N)(:N) 1509 0.0177 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 1510 0.0176 SUB835 NC1C(Cl)CCCC1 1510 0.0176 PF00001 7 transmembrane receptor (rhodopsin family), 1511 0.0166 SUB646 O=C-N-C-C 1511 0.0166 PF00026 Eukaryotic aspartyl protease 1512 0.0166 SUB802 CC1CC(Cl)CCC1 1512 0.0166 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1513 0.0166 SUB572 [#1]-C-O-[#1] 1513 0.0166 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 1514 0.0163 SUB618 C-C-C-O-[#1] 1514 0.0163 PF02155 Glucocorticoid receptor 1515 0.0159 SUB522 C:N-C-[#1] 1515 0.0159 PF00017 SH2 domain 1516 0.0157 SUB667 C=C-C-O-C 1516 0.0157 PF00690 Cation transporter/ATPase, N-terminus 1517 0.0157 SUB251 >= 1 saturated or aromatic nitrogen-containing ring size 10 1517 0.0157 PF01582 TIR domain 1518 0.0156 SUB441 C(-C)(-O)(=O) 1518 0.0156 PF00487 Fatty acid desaturase 1519 0.0156 SUB471 C:C-C=C 1519 0.0156 PF00209 Sodium:neurotransmitter symporter family 1520 0.0155 SUB406 O(~C)(~C) 1520 0.0155 PF00689 Cation transporting ATPase, C-terminus 1521 0.0155 SUB643 O-C-C-C=O 1521 0.0155 PF00168 C2 domain 1522 0.0152 SUB441 C(-C)(-O)(=O) 1522 0.0152 PF05649 Peptidase family M13 1523 0.0151 SUB315 O-P 1523 0.0151 PF00017 SH2 domain 1524 0.0149 SUB638 O-C-C-C-C 1524 0.0149 PF07686 Immunoglobulin V-set domain 1525 0.0148 SUB350 C(~C)(~H)(~S) 1525 0.0148 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 1526 0.0145 SUB701 O-C-C-C-C-C-O-C 1526 0.0145 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1527 0.0140 SUB441 C(-C)(-O)(=O) 1527 0.0140 PF08444 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region 1528 0.0135 SUB10 >= 2 C 1528 0.0135 PF00248 Aldo/keto reductase family 1529 0.0134 SUB686 O=C-C-C-C-N 1529 0.0134 PF01471 Putative peptidoglycan binding domain 1530 0.0133 SUB451 C(-N)(=N) 1530 0.0133 PF01048 Phosphorylase superfamily 1531 0.0131 SUB408 O(~C)(~P) 1531 0.0131 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 1532 0.0129 SUB664 O-C-C-O-[#1] 1532 0.0129 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 1533 0.0124 SUB646 O=C-N-C-C 1533 0.0124 PF00074 Pancreatic ribonuclease 1534 0.0121 SUB21 >= 4 O 1534 0.0121 PF00070 Pyridine nucleotide-disulphide oxidoreductase 1535 0.0121 SUB614 C-N-C-C-C 1535 0.0121 PF00520 Ion transport protein 1536 0.0120 SUB358 C(~C)(:C)(:N) 1536 0.0120 PF00001 7 transmembrane receptor (rhodopsin family), 1537 0.0120 SUB549 O-C-C:C 1537 0.0120 PF00001 7 transmembrane receptor (rhodopsin family), 1538 0.0118 SUB372 C(~H)(:C)(:C) 1538 0.0118 PF00001 7 transmembrane receptor (rhodopsin family), 1539 0.0118 SUB449 C(-H)(=O) 1539 0.0118 PF00282 Pyridoxal-dependent decarboxylase conserved domain 1540 0.0116 SUB699 O-C-C-C-C-C-C-C 1540 0.0116 PF00579 tRNA synthetases class I (W and Y), 1541 0.0115 SUB840 CC1CC(C)CC1 1541 0.0115 PF02155 Glucocorticoid receptor 1542 0.0113 SUB252 >= 1 saturated or aromatic heteroatom-containing ring size 10 1542 0.0113 PF00001 7 transmembrane receptor (rhodopsin family), 1543 0.0111 SUB592 Cl-C-C-C-C 1543 0.0111 PF03073 TspO/MBR family 1544 0.0110 SUB531 N:C-C:C 1544 0.0110 PF00017 SH2 domain 1545 0.0109 SUB380 C(~N)(:N) 1545 0.0109 PF00757 Furin-like cysteine rich region 1546 0.0106 SUB339 C(~C)(~C)(~H)(~N) 1546 0.0106 PF00133 tRNA synthetases class I (I, L, M and V), 1547 0.0102 SUB345 C(~C)(~H) 1547 0.0102 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 1548 0.0101 SUB454 N(-C)(=C) 1548 0.0101 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1549 0.0101 SUB703 O-C-C-C-C-C-N-C 1549 0.0101 PF00702 haloacid dehalogenase-like hydrolase 1550 0.0101 SUB340 C(~C)(~C)(~H)(~O) 1550 0.0101 PF00175 Oxidoreductase NAD-binding domain 1551 0.0100 SUB609 C-C-C-C:C 1551 0.0100 PF00001 7 transmembrane receptor (rhodopsin family), 1552 0.0100 SUB567 O-C-C-N 1552 0.0100 PF05995 Cysteine dioxygenase type I 1553 0.0096 SUB640 O-C-C-C-O 1553 0.0096 PF03949 Malic enzyme, NAD binding domain 1554 0.0093 SUB343 C(~C)(~Cl) 1554 0.0093 PF03073 TspO/MBR family 1555 0.0093 SUB861 CC1C(C)CCC1 1555 0.0093 PF02155 Glucocorticoid receptor 1556 0.0093 SUB350 C(~C)(~H)(~S) 1556 0.0093 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 1557 0.0093 SUB736 Cc1cc(O)ccc1 1557 0.0093 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1558 0.0092 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 1558 0.0092 PF00069 Protein kinase domain 1559 0.0092 SUB19 >= 1 O 1559 0.0092 PF03098 Animal haem peroxidase 1560 0.0091 SUB686 O=C-C-C-C-N 1560 0.0091 PF07837 Formiminotransferase domain, N-terminal subdomain 1561 0.0090 SUB382 C(~O)(:C) 1561 0.0090 PF01477 PLAT/LH2 domain 1562 0.0089 SUB686 O=C-C-C-C-N 1562 0.0089 PF00202 Aminotransferase class-III 1563 0.0089 SUB21 >= 4 O 1563 0.0089 PF00102 Protein-tyrosine phosphatase 1564 0.0089 SUB343 C(~C)(~Cl) 1564 0.0089 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1565 0.0087 SUB452 C(-N)(=O) 1565 0.0087 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1566 0.0084 SUB545 O-C:C-O 1566 0.0084 PF00643 B-box zinc finger 1567 0.0084 SUB20 >= 2 O 1567 0.0084 PF00084 Sushi domain (SCR repeat), 1568 0.0084 SUB503 N-C=C-[#1] 1568 0.0084 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1569 0.0084 SUB608 N-C-C-C:C 1569 0.0084 PF00018 SH3 domain 1570 0.0083 SUB145 >= 1 saturated or aromatic carbon-only ring size 5 1570 0.0083 PF02155 Glucocorticoid receptor 1571 0.0076 SUB440 C(-C)(-N)(=O) 1571 0.0076 PF00045 Hemopexin 1572 0.0071 SUB343 C(~C)(~Cl) 1572 0.0071 PF00520 Ion transport protein 1573 0.0068 SUB606 O=C-C-O-C 1573 0.0068 PF00520 Ion transport protein 1574 0.0066 SUB452 C(-N)(=O) 1574 0.0066 PF07992 Pyridine nucleotide-disulphide oxidoreductase 1575 0.0065 SUB622 N-C:C:C:N 1575 0.0065 PF00106 short chain dehydrogenase 1576 0.0064 SUB693 O=C-C-C-C-C-C 1576 0.0064 PF00069 Protein kinase domain 1577 0.0064 SUB31 >= 1 P 1577 0.0064 PF00074 Pancreatic ribonuclease 1578 0.0062 SUB385 C(:C)(:C) 1578 0.0062 PF00005 ABC transporter 1579 0.0060 SUB548 N-C:C-N 1579 0.0060 PF00069 Protein kinase domain 1580 0.0056 SUB635 C-C-C:C-C 1580 0.0056 PF00209 Sodium:neurotransmitter symporter family 1581 0.0054 SUB343 C(~C)(~Cl) 1581 0.0054 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1582 0.0053 SUB412 P(~O)(~O) 1582 0.0053 PF02223 Thymidylate kinase 1583 0.0052 SUB692 O-C-C-C-C-C-N 1583 0.0052 PF00868 Transglutaminase family 1584 0.0048 SUB540 N=C-C-[#1] 1584 0.0048 PF00042 Globin 1585 0.0047 SUB294 C-S 1585 0.0047 PF02798 Glutathione S-transferase, N-terminal domain 1586 0.0047 SUB621 C:C-O-C-C 1586 0.0047 PF03765 CRAL/TRIO, N-terminus 1587 0.0046 SUB347 C(~C)(~H)(~O) 1587 0.0046 PF06512 Sodium ion transport-associated 1588 0.0046 SUB551 Cl-C-C-C 1588 0.0046 PF03073 TspO/MBR family 1589 0.0046 SUB741 Oc1cc(O)ccc1 1589 0.0046 PF00069 Protein kinase domain 1590 0.0045 SUB367 C(~H)(~O) 1590 0.0045 PF00343 Carbohydrate phosphorylase 1591 0.0041 SUB664 O-C-C-O-[#1] 1591 0.0041 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 1592 0.0039 SUB618 C-C-C-O-[#1] 1592 0.0039 PF01063 Aminotransferase class IV 1593 0.0038 SUB443 C(-C)(=N) 1593 0.0038 PF03073 TspO/MBR family 1594 0.0038 SUB771 Nc1c(N)cccc1 1594 0.0038 PF00001 7 transmembrane receptor (rhodopsin family), 1595 0.0038 SUB646 O=C-N-C-C 1595 0.0038 PF00105 Zinc finger, C4 type (two domains), 1596 0.0034 SUB624 O=C-C:C-C 1596 0.0034 PF07884 Vitamin K epoxide reductase family 1597 0.0033 SUB614 C-N-C-C-C 1597 0.0033 PF00001 7 transmembrane receptor (rhodopsin family), 1598 0.0033 SUB699 O-C-C-C-C-C-C-C 1598 0.0033 PF00005 ABC transporter 1599 0.0033 SUB587 C-S-C-C-C 1599 0.0033 PF00104 Ligand-binding domain of nuclear hormone receptor 1600 0.0032 SUB366 C(~H)(~N) 1600 0.0032 PF00005 ABC transporter 1601 0.0032 SUB443 C(-C)(=N) 1601 0.0032 PF00001 7 transmembrane receptor (rhodopsin family), 1602 0.0031 SUB494 O=C-C:C 1602 0.0031 PF00464 Serine hydroxymethyltransferase 1603 0.0030 SUB407 O(~C)(~H) 1603 0.0030 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 1604 0.0030 SUB372 C(~H)(:C)(:C) 1604 0.0030 PF06512 Sodium ion transport-associated 1605 0.0029 SUB621 C:C-O-C-C 1605 0.0029 PF00650 CRAL/TRIO domain 1606 0.0029 SUB367 C(~H)(~O) 1606 0.0029 PF00059 Lectin C-type domain 1607 0.0029 SUB594 N-C-C-C-N 1607 0.0029 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1608 0.0026 SUB540 N=C-C-[#1] 1608 0.0026 PF00091 Tubulin/FtsZ family, GTPase domain 1609 0.0025 SUB693 O=C-C-C-C-C-C 1609 0.0025 PF00079 Serpin (serine protease inhibitor), 1610 0.0023 SUB407 O(~C)(~H) 1610 0.0023 PF00175 Oxidoreductase NAD-binding domain 1611 0.0020 SUB710 C-C(C)-C-C-C 1611 0.0020 PF00520 Ion transport protein 1612 0.0018 SUB565 C=C-C=C 1612 0.0018 PF00067 Cytochrome P450 1613 0.0018 SUB433 C(-C)(-C)(=O) 1613 0.0018 PF00001 7 transmembrane receptor (rhodopsin family), 1614 0.0016 SUB378 C(~N)(:C)(:C) 1614 0.0016 PF00001 7 transmembrane receptor (rhodopsin family), 1615 0.0016 SUB441 C(-C)(-O)(=O) 1615 0.0016 PF00173 Cytochrome b5-like Heme/Steroid binding domain 1616 0.0014 SUB540 N=C-C-[#1] 1616 0.0014 PF03953 Tubulin C-terminal domain 1617 0.0014 SUB24 >= 1 F 1617 0.0014 PF01180 Dihydroorotate dehydrogenase 1618 0.0013 SUB573 N:C:N:C 1618 0.0013 PF00821 Phosphoenolpyruvate carboxykinase 1619 0.0012 SUB572 [#1]-C-O-[#1] 1619 0.0012 PF00931 NB-ARC domain 1620 0.0011 SUB339 C(~C)(~C)(~H)(~N) 1620 0.0011 PF00152 tRNA synthetases class II (D, K and N), 1621 0.0010 SUB406 O(~C)(~C) 1621 0.0010 PF00168 C2 domain 1622 0.0010 SUB363 C(~Cl)(:C) 1622 0.0010 PF03073 TspO/MBR family 1623 0.0008 SUB32 >= 2 P 1623 0.0008 PF00169 PH domain 1624 0.0007 SUB793 NC1CCC(Cl)CC1 1624 0.0007 PF00343 Carbohydrate phosphorylase 1625 0.0007 SUB607 O-C:C-C-C 1625 0.0007 PF00001 7 transmembrane receptor (rhodopsin family), 1626 0.0006 SUB457 P(-O)(=O) 1626 0.0006 PF03770 Inositol polyphosphate kinase 1627 0.0003 SUB647 O=C-N-C-[#1] 1627 0.0003 PF00026 Eukaryotic aspartyl protease 1628 0.0003 SUB360 C(~C)(:N)(:N) 1628 0.0003 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 1629 0.0002 SUB567 O-C-C-N 1629 0.0002 PF00664 ABC transporter transmembrane region 1630 0.0002 SUB369 C(~H)(~S) 1630 0.0002 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 1631 0.0001 SUB664 O-C-C-O-[#1] 1631 0.0001 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 1632 0.0001 SUB571 C:C-C-C 1632 0.0001 PF00001 7 transmembrane receptor (rhodopsin family), 1633 0.0000 SUB408 O(~C)(~P) 1633 0.0000 PF03770 Inositol polyphosphate kinase 1634 0.0000 SUB686 O=C-C-C-C-N 1634 0.0000 PF02971 Formiminotransferase domain 1635 0.0000 SUB32 >= 2 P 1635 0.0000 PF03770 Inositol polyphosphate kinase 1636 0.0000 SUB414 S(~C)(~H) 1636 0.0000 PF01406 tRNA synthetases class I (C), catalytic domain 1637 0.0000 SUB32 >= 2 P 1637 0.0000 PF00025 ADP-ribosylation factor family