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Saccharomyces cerevisiae - Functional Catalogue |
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CELL GROWTH, CELL DIVISION AND DNA SYNTHESIS (833 ORFs)
YGR032w GSC2 1,3-beta-D-glucan synthase subunit YIL124w AYR1 1-Acyldihydroxyacetone-phosphate reductase YPL268w PLC1 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase YER177w BMH1 14-3-3 protein involved in rapamycin-sensitive signalling YJL001w PRE3 20S proteasome subunit (beta1) YPR103w PRE2 20S proteasome subunit (beta5) YER012w PRE1 20S proteasome subunit C11(beta4) YGR253c PUP2 20S proteasome subunit(alpha5) YFR052w RPN12 26S proteasome regulatory subunit YGL048c RPT6 26S proteasome regulatory subunit YKL145w RPT1 26S proteasome regulatory subunit YOL021c DIS3 3'->5' exoribonuclease required for 3' end formation of 5.8S rRNA YGR214w RPS0A 40S ribosomal protein p40 homolog A YLR075w RPL10 60S large subunit ribosomal protein YNR044w AGA1 a-agglutinin anchor subunit YGL032c AGA2 a-agglutinin binding subunit YBL015w ACH1 acetyl-CoA hydrolase YFL039c ACT1 actin YDR129c SAC6 actin filament bundling protein, fimbrin YBR211c AME1 actin related protein YCR088w ABP1 actin-binding protein YIR006c PAN1 actin-cytoskeleton assembly protein YDL029w ARP2 actin-like protein YCR048w ARE1 acyl-CoA sterol acyltransferase YNR019w ARE2 acyl-CoA sterol acyltransferase YBR133c HSL7 adapter in a regulatory pathway that relieves tyrosine phosphorylation of CDC28 YOL052c SPE2 adenosylmethionine decarboxylase precursor YJL005w CYR1 adenylate cyclase YNL138w SRV2 adenylate cyclase-associated protein, 70kDa YER170w ADK2 adenylate kinase, mitochondrial YDL226c GCS1 ADP-ribosylation factor GTPase-activating protein (ARF-GAP) YGL127c SOH1 allows HPR1 null mutant to grow at 37 deg. YML085c TUB1 alpha-1 tubulin YML124c TUB3 alpha-3 tubulin YJR004c SAG1 alpha-agglutinin YDR264c AKR1 ankyrin repeat-containing protein YPL239w YAR1 ankyrin repeat-containing protein YGL213c SKI8 antiviral protein of the beta-transducin (WD-40) repeat family YDR173c ARG82 arginine metabolism transcription factor YBR234c ARC40 ARP2/3 protein complex subunit, 40 kilodalton YKL112w ABF1 ARS-binding factor YKL209c STE6 ATP-binding cassette transporter protein YIL015w BAR1 barrierpepsin precursor YBL085w BOI1 BEM1 protein-binding protein YFL037w TUB2 beta-tubulin YOR265w RBL2 beta-tubulin binding protein YHR101c BIG1 big cells phenotype YER016w BIM1 binding to microtubules YHR208w BAT1 branched chain amino acid aminotransferase, mitochondrial YBR200w BEM1 bud emergence mediator YPL161c BEM4 bud emergence protein YDR351w SBE2 bud growth protein YNL233w BNI4 bud neck involved YLR319c BUD6 bud site selection protein YCL014w BUD3 budding protein YER114c BOI2 budding protein YGR041w BUD9 budding protein YJR092w BUD4 budding protein YLR353w BUD8 budding protein YGR230w BNS1 Bypasses Need for SPO12P YLR248w RCK2 Ca/calmodulin-dependent ser/thr protein kinase YFR014c CMK1 Ca2+/calmodulin-dependent ser/thr protein kinase type I YLR433c CNA1 calcineurin B, catalytic subunit YML057w CMP2 calcineurin B, catalytic subunit YKL190w CNB1 calcineurin B, regulatory subunit YGR217w CCH1 calcium channel protein YBR109c CMD1 calmodulin YMR154c RIM13 calpain-like cysteine protease YIL033c BCY1 cAMP dependent protein kinase, regulatory subunit YHR135c YCK1 casein kinase I isoform YNL154c YCK2 casein kinase I isoform YPL204w HRR25 casein kinase I, ser/thr/tyr protein kinase YOR061w CKA2 casein kinase II alpha' chain YIL035c CKA1 casein kinase II, catalytic alpha chain YER123w YCK3 casein kinase, isoform 3 YHL022c SPO11 catalytic subunit of the meiotic double strand break transesterase YLR318w EST2 catalytic subunit of the telomerase YLR178c TFS1 CDC25-dependent nutrient- and ammonia-response cell-cycle regulator YGR049w SCM4 CDC4 suppressor YDR309c GIC2 CDC42 GTPase-binding protein YHR061c GIC1 CDC42 GTPase-binding protein YFL029c CAK1 cdk-activating protein kinase YMR055c BUB2 cell cycle arrest protein YOR026w BUB3 cell cycle arrest protein YBR136w MEC1 cell cycle checkpoint protein YDR499w LCD1 cell cycle checkpoint protein YER173w RAD24 cell cycle checkpoint protein YPR111w DBF20 cell cycle protein kinase related to DBF2P YDR113c PDS1 cell cycle regulator YBR215w HPC2 cell cycle regulatory protein YOR373w NUD1 cell cycle regulatory protein YBR202w CDC47 cell division control protein YCR002c CDC10 cell division control protein YDL220c CDC13 cell division control protein YDR168w CDC37 cell division control protein YDR182w CDC1 cell division control protein YDR364c CDC40 cell division control protein YFL009w CDC4 cell division control protein YGL116w CDC20 cell division control protein YJL194w CDC6 cell division control protein YLR274w CDC46 cell division control protein YLR314c CDC3 cell division control protein YNL188w KAR1 cell division control protein YPL255w BBP1 cell division control protein YCR094w CDC50 cell division cycle mutant YCL027w FUS1 cell fusion protein YJL174w KRE9 cell wall synthesis protein YNL327w EGT2 cell-cycle regulation protein YHR129c ARP1 centractin YNL192w CHS1 chitin synthase I YBR038w CHS2 chitin synthase II YBR023c CHS3 chitin synthase III YLR330w CHS5 chitin synthesis protein YBR195c MSI1 chromatin assembly complex, subunit p50 YML102w CAC2 chromatin assembly complex, subunit p60 YPR018w RLF2 chromatin assembly complex, subunit p90 YKL108w SLD2 chromosomal DNA replication protein YDR254w CHL4 chromosome segregation protein YFL008w SMC1 chromosome segregation protein YFR031c SMC2 chromosome segregation protein YOR349w CIN1 chromosome segregation protein YLR025w SNF7 class E Vps protein YGR167w CLC1 clathrin light chain YLL050c COF1 cofilin, actin binding and severing protein YDR251w PAM1 coiled-coil protein multicopy suppressor of loss of PP2A YOR181w LAS17 component of actin cortical patches YMR106c YKU80 component of DNA end-joining repair pathway YER008c SEC3 component of exocyst complex YOR290c SNF2 component of SWI/SNF global transcription activator complex YPL016w SWI1 component of SWI/SNF global transcription activator complex YBR289w SNF5 component of SWI/SNF transcription activator complex YDR073w SNF11 component of SWI/SNF transcription activator complex YGL240w DOC1 component of the anaphase promoting complex YLR127c APC2 component of the anaphase promoting complex YOR249c APC5 component of the anaphase-promoting complex YKL049c CSE4 component of the core centromere YPL174c NIP100 component of the dynactin complex YOL091w SPO21 component of the meiotic plaque, required for formation of the prospore membrane YMR028w TAP42 component of the Tor signaling pathway YDL132w CDC53 controls G1/S transition YPL269w KAR9 cortical protein required for cytoplasmic microtubule orientation and nuclear migration YKL011c CCE1 cruciform-cutting endonuclease, mitochondrial YGR109c CLB6 cyclin, B-type YPR120c CLB5 cyclin, B-type YAL040c CLN3 cyclin, G1/S-specific YDL127w PCL2 cyclin, G1/S-specific YMR199w CLN1 cyclin, G1/S-specific YNL289w PCL1 cyclin, G1/S-specific YPL256c CLN2 cyclin, G1/S-specific YDL155w CLB3 cyclin, G2/M-specific YGR108w CLB1 cyclin, G2/M-specific YLR210w CLB4 cyclin, G2/M-specific YPR119w CLB2 cyclin, G2/M-specific YPL042c SSN3 cyclin-dependent CTD kinase YJL157c FAR1 cyclin-dependent kinase inhibitor (CKI) YBR135w CKS1 cyclin-dependent kinases regulatory subunit YBR160w CDC28 cyclin-dependent protein kinase YPL031c PHO85 cyclin-dependent protein kinase YDL108w KIN28 cyclin-dependent ser/thr protein kinase YGL215w CLG1 cyclin-like protein YDR402c DIT2 cytochrome P450 56 YBL007c SLA1 cytoskeleton assembly control protein YNL243w SLA2 cytoskeleton assembly control protein YMR017w SPO20 DBF2P interacting protein YAL034w-a MTW1 determining metaphase spindle length YDR260c SWM1 developmentally regulated gene, is required for spore wall assembly YDR284c DPP1 diacylglycerol pyrophosphate phosphatase YLR226w BUR2 divergent CDK-cyclin complex YOR368w RAD17 DNA damage checkpoint control protein YPL194w DDC1 DNA damage checkpoint protein YER176w ECM32 DNA dependent ATPase/DNA helicase B YHR164c DNA2 DNA helicase YLR032w RAD5 DNA helicase YMR190c SGS1 DNA helicase YKL017c HCS1 DNA helicase A YML061c PIF1 DNA helicase involved in mitochondrial DNA repair and telomere length YHR031c RRM3 DNA helicase involved in rDNA replication and Ty1 transposition YDL164c CDC9 DNA ligase YOR005c DNL4 DNA ligase IV YGL090w LIF1 DNA ligase IV interacting factor YCR092c MSH3 DNA mismatch repair protein YDR097c MSH6 DNA mismatch repair protein YMR167w MLH1 DNA mismatch repair protein YNL082w PMS1 DNA mismatch repair protein YOL090w MSH2 DNA mismatch repair protein YHR120w MSH1 DNA mismatch repair protein, mitochondrial YCR014c POL4 DNA polymerase YIL139c REV7 DNA polymerase zeta subunit YMR224c MRE11 DNA repair and meiotic recombination protein YJR035w RAD26 DNA repair and recombination protein YDR217c RAD9 DNA repair checkpoint protein YCR066w RAD18 DNA repair protein YDR004w RAD57 DNA repair protein YDR076w RAD55 DNA repair protein YDR369c XRS2 DNA repair protein YEL019c MMS21 DNA repair protein YER095w RAD51 DNA repair protein YML095c RAD10 DNA repair protein YNL250w RAD50 DNA repair protein YJL173c RFA3 DNA replication factor A, 13 KD subunit YNL312w RFA2 DNA replication factor A, 36 kDa subunit YAR007c RFA1 DNA replication factor A, 69 KD subunit YOL094c RFC4 DNA replication factor C, 37 kDa subunit YBR087w RFC5 DNA replication factor C, 40 KD subunit YNL290w RFC3 DNA replication factor C, 40 kDa subunit YJR068w RFC2 DNA replication factor C, 41 KD subunit YOR217w RFC1 DNA replication factor C, 95 KD subunit YDR110w FOB1 DNA replication fork blocking protein YOL006c TOP1 DNA topoisomerase I YNL088w TOP2 DNA topoisomerase II (ATP-hydrolysing) YLR234w TOP3 DNA topoisomerase III YNL216w RAP1 DNA-binding protein with repressor and activator activity YGL163c RAD54 DNA-dependent ATPase of the SNF2P family YKL045w PRI2 DNA-directed DNA polymerase alpha , 58 KD subunit (DNA primase) YIR008c PRI1 DNA-directed DNA polymerase alpha 48kDa subunit (DNA primase) YNL102w POL1 DNA-directed DNA polymerase alpha, 180 KD subunit YBL035c POL12 DNA-directed DNA polymerase alpha, 70 KD subunit YPR135w CTF4 DNA-directed DNA polymerase alpha-binding protein YJR006w HYS2 DNA-directed DNA polymerase delta, 55 KD subunit YDL102w CDC2 DNA-directed DNA polymerase delta, catalytic 125 KD subunit YFR023w PES4 DNA-directed DNA polymerase epsilon suppressor YNL262w POL2 DNA-directed DNA polymerase epsilon, catalytic subunit A YPR175w DPB2 DNA-directed DNA polymerase epsilon, subunit B YBR278w DPB3 DNA-directed DNA polymerase epsilon, subunit C YOR330c MIP1 DNA-directed DNA polymerase gamma catalytic subunit, mitochondrial YPL167c REV3 DNA-directed DNA polymerase zeta subunit YNL025c SSN8 DNA-directed RNA polymerase II holoenzyme and Kornberg's mediator (SRB) subcomplex subunit, cyclin C homolog YOL051w GAL11 DNA-directed RNA polymerase II holoenzyme and Kornberg's mediator (SRB) subcomplex subunit YLR071c RGR1 DNA-directed RNA polymerase II holoenzyme subunit YBR253w SRB6 DNA-directed RNA polymerase II suppressor protein YFL036w RPO41 DNA-directed RNA polymerase, mitochondrial YMR013c SEC59 dolichol kinase YLR129w DIP2 DOM34P-interacting protein YFR028c CDC14 dual specificity phosphatase YNL053w MSG5 dual-specifity protein phosphatase YKR054c DYN1 dynein heavy chain, cytosolic YBR082c UBC4 E2 ubiquitin-conjugating enzyme YDL064w UBC9 E2 ubiquitin-conjugating enzyme YDR054c CDC34 E2 ubiquitin-conjugating enzyme YDR059c UBC5 E2 ubiquitin-conjugating enzyme YDR177w UBC1 E2 ubiquitin-conjugating enzyme YER100w UBC6 E2 ubiquitin-conjugating enzyme YGL058w RAD6 E2 ubiquitin-conjugating enzyme YMR022w QRI8 E2 ubiquitin-conjugation enzyme YDR457w TOM1 E3 ubiqitin ligase required for G2/M transition YPL046c ELC1 Elongin C transcription elongation factor YKR056w RNC1 endo-exonuclease YLR286c CTS1 endochitinase YNL238w KEX2 endoproteinase of late golgi compartment YGL054c ERV14 ER-derived Vesicles YFL017c GNA1 essential acetyltransferase YGL180w APG1 essential for autophagocytosis YHR184w SSP1 essential for meiosis and spore formation YGR113w DAM1 essential mitotic spindle pole protein YGL061c DUO1 essential mitotic spindle protein YIL026c IRR1 essential protein YDR172w SUP35 eukaryotic peptide chain release factor GTP-binding subunit YOR190w SPR1 exo-1,3-beta-glucanase precursor YLR300w EXG1 exo-beta-1,3-glucanase (I/II), major isoform YDR261c EXG2 exo-beta-1,3-glucanase minor isoform YOR033c EXO1 exonuclease which interacts with MSH2P YKL007w CAP1 F-actin capping protein alpha subunit YIL034c CAP2 F-actin capping protein, beta subunit YCR034w FEN1 fatty acid elongase required for sphingolipid formation YBL097w BRN1 functional homologue of human BRRN1 YNL001w DOM34 functions in protein translation to promote G1 progression and differentiation YDL035c GPR1 G-protein coupled receptor YIR024c GIF1 G1 Factor needed for normal G1 phase YLR288c MEC3 G2-specific checkpoint protein YLR212c TUB4 gamma tubulin YLR299w ECM38 gamma-glutamyltransferase, involved in glutathione synthesis YAL024c LTE1 GDP/GTP exchange factor YLL016w SDC25 GDP/GTP exchange factor (GEF) YGL097w SRM1 GDP/GTP exchange factor for GSP1P/GSP2P YLR310c CDC25 GDP/GTP exchange factor for RAS1P and RAS2P YLR371w ROM2 GDP/GTP exchange factor for RHO1P YCR038c BUD5 GDP/GTP exchange factor for RSR1P/Bud1p YGR070w ROM1 GDP/GTP exchange protein for RHO1P YGL207w SPT16 general chromatin factor YDR392w SPT3 general transcriptional adaptor or co-activator YGL155w CDC43 geranylgeranyltransferase beta subunit YNL153c GIM3 Gim complex component YGR078c PAC10 GIM4 - Gim complex component YBR045c GIP1 GLC7-interacting protein YNL236w SIN4 global regulator protein YHL025w SNF6 global transcription activator YPR159w KRE6 glucan synthase subunit YKL104c GFA1 glucosamine--fructose-6-phosphate transaminase YBR212w NGR1 glucose-repressible RNA-binding protein YHR103w SBE22 golgi protein involved in yeast cell wall formation YOR043w WHI2 growth regulation protein YGR152c RSR1 GTP-binding protein YMR138w CIN4 GTP-binding protein YNL098c RAS2 GTP-binding protein YOR101w RAS1 GTP-binding protein YHR005c GPA1 GTP-binding protein alpha subunit of the pheromone pathway YOR212w STE4 GTP-binding protein beta subunit of the pheromone pathway YJR086w STE18 GTP-binding protein gamma subunit of the pheromone pathway YLR229c CDC42 GTP-binding protein of RAS superfamily YNL173c MDG1 GTP-binding protein of the pheromone-response pathway YFL005w SEC4 GTP-binding protein of the ras superfamily YML064c TEM1 GTP-binding protein of the RAS superfamily YIL118w RHO3 GTP-binding protein of the rho family YKR055w RHO4 GTP-binding protein of the rho family YNL090w RHO2 GTP-binding protein of the RHO subfamily of RAS-like proteins YPR165w RHO1 GTP-binding protein of the rho subfamily of ras-like proteins YAL041w CDC24 GTP/GDP exchange factor for CDC42P YER155c BEM2 GTPase-activating protein YKL092c BUD2 GTPase-activating protein for Bud1p/RSR1P YPL115c BEM3 GTPase-activating protein for CDC42P and RHO1P YDL240w LRG1 GTPase-activating protein of the rho/rac family YER020w GPA2 guanine nucleotide-binding regulatory protein YNL007c SIS1 heat shock protein YPL240c HSP82 heat shock protein YGL073w HSF1 heat shock transcription factor YER125w RSP5 hect domain E3 ubiquitin-protein ligase YMR072w ABF2 high mobility group protein YMR284w YKU70 high-affinity DNA-binding protein YBR138c HDR1 High-Dosage Reductional segregation defective YNL330c RPD3 histone deacetylase B YDL227c HO homothallic switching endonuclease YKL117w SBA1 Hsp90 (Ninety) Associated Co-chaperone YDR138w HPR1 hyperrecombination protein related to TOP1P YKR046c hypothetical protein YBL028c hypothetical protein - involved in mating-type regulation YJL146w IDS2 IME2-dependent signaling protein YPL164c MLH3 insertion and deletion mismatch repair protein YOR156c NFI1 interacts with CDC12P in 2-hybrid assay YML104c MDM1 intermediate filament protein YMR100w MUB1 involved in budding YNL291c MID1 involved in Ca2+ influx during mating YIL123w SIM1 involved in cell cycle regulation and aging YJR140c HIR3 involved in cell cycle regulation of histone transcription YKR072c SIS2 involved in cell cycle-specific gene expression YGR238c KEL2 involved in cell fusion and morphogenesis YHR158c KEL1 involved in cell fusion and morphology YKL021c MAK11 involved in cell growth and replication of M1 dsRNA virus YKR063c LAS1 involved in cell morphogenesis, cytoskeletal regulation and bud formation YLL021w SPA2 involved in cell polarity YBR078w ECM33 involved in cell wall biogenesis and architecture YHR119w SET1 involved in chromatin-mediated gene regulation YPL018w CTF19 involved in chromosome segregation YPL241c CIN2 involved in chromosome segregation YPR046w MCM16 involved in chromosome segregation YOR195w SLK19 involved in control of spindle dynamics together with KAR3P YMR032w HOF1 involved in cytokinesis YNL225c CNM67 involved in cytokinesis YPL242c IQG1 involved in cytokinesis, has similarity to mammalian IQGAP proteins YLR452c SST2 involved in desensitization to alpha-factor pheromone YJL090c DPB11 involved in DNA replication and S-phase checkpoint YDR068w DOS2 involved in genome stability YOR030w DFG16 involved in invasive growth upon nitrogen starvation YDR296w MHR1 Involved in mitochondrial homologous DNA recombination YDR085c AFR1 involved in morphogenesis of the mating projection YMR273c ZDS1 involved in negative regulation of cell polarity YCR086w CSM1 involved in nuclear migration YER149c PEA2 involved in oriented growth toward mating partner YMR052w FAR3 involved in pheromone-mediated cell cycle arrest YMR165c SMP2 involved in plasmid maintenance, respiration and cell proliferation YDR299w BFR2 involved in protein transport steps at the Brefeldin A blocks YNL197c WHI3 involved in regulation of cell size YMR001c CDC5 involved in regulation of DNA replication YIL046w MET30 involved in regulation of sulfur assimilation genes and cell cycle progression YGL201c MCM6 involved in replication YMR127c SAS2 involved in silencing at HMR YDR180w SCC2 involved in sister chromatid cohesion YFR027w ECO1 involved in sister chromatid cohesion during replication YDR022c CIS1 involved in suppression of CIK1 mutation YDR082w STN1 involved in telomere length regulation YKR042w UTH1 involved in the aging process YER007w PAC2 involved in the stabilization of microtubles YDR293c SSD1 involved in the tolerance to high concentration of Ca2+ YOR336w KRE5 killer toxin-resistance protein YCL024w KCC4 kinase coordinate cell cycle progression with the organization of the peripheralcytoskeleton YBL063w KIP1 kinesin-related protein YEL061c CIN8 kinesin-related protein YKL079w SMY1 kinesin-related protein YPL155c KIP2 kinesin-related protein YPR141c KAR3 kinesin-related protein YGL216w KIP3 kinesin-related protein required for nuclear migration YJR060w CBF1 kinetochore protein YGR140w CBF2 kinetochore protein complex CBF3, 110 KD subunit YDR328c SKP1 kinetochore protein complex CBF3, subunit D YMR168c CEP3 kinetochore protein complex, 71 KD subunit YMR094w CTF13 kinetochore protein complex, CBF3, 58 KD subunit YKL149c DBR1 lariat-debranching enzyme YHL003c LAG1 longevity-assurance protein YMR036c MIH1 M-phase inducing protein tyrosine phosphatase YOR198c BFR1 maintenance of normal ploidy YDR480w DIG2 MAP kinase-associated protein, down-regulator of invasive growth and mating YPL049c DIG1 MAP kinase-associated protein, down-regulator of invasive growth and mating YDR461w MFA1 mating pheromone a-factor 1 YNL145w MFA2 mating pheromone a-factor 2 YPL187w MFALPHA1 mating pheromone alpha-1 precursor YGL089c MF(ALPHA)2 mating pheromone alpha-2 factor YLR332w MID2 mating process protein YHR066w SSF1 mating protein YCR039c MATALPHA2 mating type regulatory protein, expressed copy at MAT locus YCR040w MATALPHA1 mating type regulatory protein, expressed copy at MAT locus YCL066w HMLALPHA1 mating type regulatory protein, silenced copy at HML YCL067c HMLALPHA2 mating type regulatory protein, silenced copy at HML YCR096c A2 mating type regulatory protein, silenced copy at HMR locus YCR097w A1 mating type regulatory protein, silenced copy at HMR locus YDR143c SAN1 mating-type regulation protein YLL017w maybe part of SCD25 YGL025c PGD1 mediator complex subunit YHR079c-a SAE3 meiosis specific protein YDL154w MSH5 meiosis-specific protein YER044c-a MEI4 meiosis-specific protein YER179w DMC1 meiosis-specific protein YER180c ISC10 meiosis-specific protein YFL003c MSH4 meiosis-specific protein YHR014w SPO13 meiosis-specific protein YHR124w NDT80 meiosis-specific protein YHR157w REC104 meiosis-specific protein YIL072w HOP1 meiosis-specific protein YLR263w RED1 meiosis-specific protein YAL009w SPO7 meiotic protein YBR057c MUM2 meiotic protein YPL121c MEI5 meiotic protein YGL175c SAE2 meiotic recombination protein YHR086w NAM8 meiotic recombination protein YJR021c REC107 meiotic recombination protein YLR329w REC102 meiotic recombination protein YMR133w REC114 meiotic recombination protein YNL210w MER1 meiotic recombination protein YHL027w RIM101 meiotic regulatory protein YOL104c NDJ1 meiotic telomere protein YPR019w CDC54 member of the CDC46P/MCM2P/MCM3P family YJR032w CPR7 member of the cyclophilin family YJR089w BIR1 member of the inhibitor of apoptosis family, participate in chromosome segregation events YIL047c SYG1 member of the major facilitator superfamily YBL023c MCM2 member of the MCM2P,MCM3P,CDC46P family YJL159w HSP150 member of the PIR1P/HSP150P/PIR3P family YDR191w HST4 member of the SIR2P family of putative NAD-dependent histone deacetylases YLR131c ACE2 metallothionein expression activator YDL126c CDC48 microsomal protein of CDC48/PAS1/SEC18 family of ATPases YOR058c ASE1 microtubule-associated protein (nonmotor) YOR272w YTM1 microtubule-interacting protein YBR272c HSM3 mismatch repair protein YNL064c YDJ1 mitochondrial and ER import protein YGR029w ERV1 mitochondrial biogenesis and regulation of cell cycle YOL095c HMI1 mitochondrial DNA helicase YLR369w SSQ1 mitochondrial heat shock protein 70 YBL016w FUS3 mitogen-activated protein kinase (MAP kinase) YMR294w JNM1 mitosis protein, involved in nuclear migration YDL003w MCD1 Mitotic Chromosome Determinant YBR156c SLI15 Mitotic spindle protein involved in chromosome segregation YOR188w MSB1 morphogenesis-related protein YGR014w MSB2 multicopy suppressor of a CDC24 bud emergence defect YGL178w MPT5 multicopy suppressor of POP2 YML109w ZDS2 multicopy suppressor of SIN4 YDR335w MSN5 multicopy supressor of SNF1 mutation YGL173c KEM1 multifunctional nuclease YMR200w ROT1 mutant suppresses TOR2 mutation YGL106w MLC1 MYO2P light chain YOR326w MYO2 myosin heavy chain YAL029c MYO4 myosin heavy chain, unconventional (class V) isoform YMR109w MYO5 myosin I YKL129c MYO3 myosin type I YHR023w MYO1 myosin-1 isoform (type II myosin) heavy chain YNL339c YRF1-6 nearly identical to other subtelomerically encoded putative helicases YOL076w MDM20 necessary for mitochondrial inheritance and organisation of the actin cytoskeleton YER132c PMD1 negative regulator of early meiotic expression YGL197w MDS3 negative regulator of early meiotic expression YKL185w ASH1 negative regulator of HO transcription YPL139c UME1 negative regulator of meiosis YDR207c UME6 negative transcriptional regulator YHL024w RIM4 No sporulation YBR089c-a NHP6B nonhistone chromosomal protein YPR052c NHP6A nonhistone chromosomal protein related to mammalian HMG1 YBL020w RFT1 nuclear division protein YNL299w TRF5 nuclear division protein YJR112w NNF1 nuclear envelope protein YML031w NDC1 nuclear envelope protein YCL029c BIK1 nuclear fusion protein YJL034w KAR2 nuclear fusion protein YMR065w KAR5 nuclear fusion protein YDR150w NUM1 nuclear migration protein YDL116w NUP84 nuclear pore protein YGL100w SEH1 nuclear pore protein YJR042w NUP85 nuclear pore protein YKR082w NUP133 nuclear pore protein YCR093w CDC39 nuclear protein YAL025c MAK16 nuclear viral propagation protein YKR048c NAP1 nucleosome assembly protein I YBR114w RAD16 nucleotide excision repair protein YEL037c RAD23 nucleotide excision repair protein (ubiquitin-like protein) YGL091c NBP35 nucleotide-binding protein YJL212c OPT1 oligopeptide transporter specific for tetra- and pentapeptides YML065w ORC1 origin recognition complex, 104 KD subunit YHR118c ORC6 origin recognition complex, 50 KD subunit YNL261w ORC5 origin recognition complex, 50 kDa subunit YPR162c ORC4 origin recognition complex, 56 KD subunit YLL004w ORC3 origin recognition complex, 62 kDa subunit YBR060c ORC2 origin recognition complex, 72 kDa subunit YLR079w SIC1 p40 inhibitor of CDC28P-Clb protein kinase complex YCL016c DCC1 part of an alternative RFC complex YCR057c PWP2 periodic tryptophan protein YKL178c STE3 pheromone a-factor receptor YFL026w STE2 pheromone alpha-factor receptor YPR075c OPY2 pheromone resistant yeast 2 YCL032w STE50 pheromone response pathway protein YDR103w STE5 pheromone signal transduction pathway protein YCL004w PGS1 phosphatidylglycerophosphate synthase YJR066w TOR1 phosphatidylinositol 3-kinase YKL203c TOR2 phosphatidylinositol 3-kinase YNL267w PIK1 phosphatidylinositol 4-kinase YLR305c STT4 phosphatidylinositol-4-kinase YDR208w MSS4 phosphatidylinositol-4-phosphate 5-kinase YKR031c SPO14 phospholipase D YBL106c SRO77 polarized exocytosis by regulating SNARE function YPR032w SRO7 polarized exocytosis by regulating SNARE function YJR043c POL32 polymerase-associated gene, third (55 kDa) subunit of DNA polymerase delta YGL192w IME4 positive transcription factor for IME2 YGR023w MTL1 potential cell wall stres sensor YBL058w SHP1 potential regulatory subunit for GLC7P YMR076c PDS5 precocious dissociation of sister chromatids YOR122c PFY1 profilin YGR231c PHB2 Prohibitin YGR132c PHB1 prohibitin, antiproliferative protein YBR088c POL30 Proliferating Cell Nuclear Antigen (PCNA) YPR122w AXL1 protease YLR389c STE23 protease involved in a-factor processing YML058w SML1 protein inhibitor of ribonucleotide reductase YOL142w RRP40 protein involved in ribosomal RNA processing, component of the exosome complex responsible for 3' end processing and degradation of many RNA species YDR104c SPO71 protein involved in spore wall formation YDR030c RAD28 protein involved in the same pathway as RAD26P, has beta-transducin (WD-40) repeats YDL017w CDC7 protein kinase YOR149c SMP3 protein kinase C pathway protein YPL140c MKK2 protein kinase of the map kinase kinase (MEK) family YAR019c CDC15 protein kinase of the MAP kinase kinase kinase family YHR013c ARD1 protein N-acetyltransferase subunit YPL008w CHL1 protein of the DEAH box family YGL075c MPS2 Protein of the nuclear envelope/endoplasmic reticulum required for spindle pole body assembly and normal chromosome segregation YPR007c SPO69 protein required for meiosis and sporulation YOR372c NDD1 protein required for nuclear division YLR394w CST9 protein required for synapsis, meiotic recombination, sporulation, proper chromosome segregation, and synaptonemal complex formation YDR075w PPH3 protein ser/thr phosphatase YDL134c PPH21 protein ser/thr phosphatase PP2A-1 YDL188c PPH22 protein ser/thr phosphatase PP2A-2 YDL006w PTC1 protein serine/threonine phosphatase 2c YGR009c SEC9 protein transport protein YBR276c PPS1 protein tyrosine phosphatase YER075c PTP3 protein tyrosine phosphatase YIR026c YVH1 protein tyrosine phosphatase YDR312w SSF2 protein with a potential role in mating YLR466w YRF1-4 protein with similarity to other subtelomerically-coded Y'-helicase proteins YOR208w PTP2 protein-tyrosine-phosphatase YNL292w PUS4 pseudouridine synthase YBR186w PCH2 putative ATPase YDR440w DOT1 putative ATPase YLR175w CBF5 putative rRNA pseuduridine synthase YBL066c SEF1 putative transcription factor YBR098w MMS4 putative transcriptional (co)activator for DNA damage YOL110w SHR5 RAS suppressor YDL059c RAD59 recombination and DNA repair protein YML032c RAD52 recombination and DNA repair protein YLR383w RHC18 recombination repair protein YDR137w RGP1 reduced growth phenotype protein YDR388w RVS167 reduced viability upon starvation protein YMR063w RIM9 regulator for sporulation and invasive growth YIL159w BNR1 regulator of budding YNL271c BNI1 regulator of budding YDR363w-a SEM1 regulator of exocytosis and pseudohyphal differentiation YMR016c SOK2 regulatory protein in the PKA signal transduction pathway YCL055w KAR4 regulatory protein required for pheromone induction of karyogamy genes YDR052c DBF4 regulatory subunit for CDC7P protein kinase YKL193c SDS22 regulatory subunit for the mitotic function of type I protein phosphatase YBR274w CHK1 regulats inhibitory Cdk phosphorylation of PDS1 YEL032w MCM3 replication initiation protein YMR213w CEF1 required during G2/M transition YMR078c CTF18 required for accurate chromosome transmission in mitosis and maintenance of normal telomere length YIL140w AXL2 required for axial pattern of budding YLR313c SPH1 required for bipolar bud site selection YMR232w FUS2 required for cell fusion during mating YIL106w MOB1 required for completion of mitosis and maintenance of ploidy YER109c FLO8 required for diploid filamentous growth YBR040w FIG1 required for efficient mating YCR089w FIG2 required for efficient mating YNL084c END3 required for endocytosis and cytoskeletal organization YMR238w DFG5 required for filamentous growth, cell polarity, and cellular elongation YOL145c CTR9 required for G1 cyclin expression YNR052c POP2 required for glucose derepression YJR090c GRR1 required for glucose repression and for glucose and cation transport YFL034c-b MOB2 required for maintenance in ploidy YJR135c MCM22 required for maintenance of chromosomes and minichromosomes YJL080c SCP160 required for maintenance of exact ploidy YPL057c SUR1 required for mannosylation of sphingolipids YOR298w MUM3 required for meiosis YGL249w ZIP2 required for meiotic recombination and disjunction YLR103c CDC45 required for minichromosome maintenance and initiation of chromosomal DNA replication YPR082c DIB1 required for mitosis YBR073w RDH54 required for mitotic diploid-specific recombination and repair and meiosis YBR130c SHE3 required for mother cell-specific expression of HO YKL130c SHE2 required for mother cell-specific expression of HO YOR035c SHE4 required for mother cell-specific gene expression YGR216c GPI1 required for N-acetylglucosaminyl phosphatidylinositol synthesis YKL089w MIF2 required for normal chromosome segregation and spindle integrity YHR004c NEM1 required for nuclear morphology YGL033w HOP2 required for pairing of homologous chromosomes YIL150c DNA43 required for S-phase initiation or completion YGR098c ESP1 required for sister chromatid separation YGR225w AMA1 required for sporulation YNL242w APG2 required for sporulation YJL074c SMC3 required for structural maintenance of chromosomes YIL009c-a EST3 required for telomerase function YDR488c PAC11 required in the absence of CIN8P YDL135c RDI1 rho GDP dissociation inhibitor with activity toward RHO1P YOR127w RGA1 RHO-type GTPase-activating protein for CDC42P YER070w RNR1 ribonucleoside-diphosphate reductase, large subunit YJL026w RNR2 ribonucleoside-diphosphate reductase, small subunit YGR180c RNR4 ribonucleotide reductase small subunit YIL066c RNR3 ribonucleotide reductase, repair inducible large subunit YKL181w PRS1 ribose-phosphate pyrophosphokinase YLR441c RPS1A ribosomal protein S3a.e YMR228w MTF1 RNA polymerase specific factor, mitochondrial YDL225w SHS1 septin YHR107c CDC12 septin YJR076c CDC11 septin YDR218c SPR28 septin-related sporulation protein YGL190c CDC55 ser/thr phosphatase 2A regulatory subunit B YER133w GLC7 ser/thr phosphoprotein phosphatase 1, catalytic chain YBL105c PKC1 ser/thr protein kinase YDR507c GIN4 ser/thr protein kinase YDR523c SPS1 ser/thr protein kinase YGL158w RCK1 ser/thr protein kinase YGR188c BUB1 ser/thr protein kinase YJL106w IME2 ser/thr protein kinase YJL141c YAK1 ser/thr protein kinase YMR104c YPK2 ser/thr protein kinase YMR139w RIM11 ser/thr protein kinase YNL298w CLA4 ser/thr protein kinase YOR231w MKK1 ser/thr protein kinase YOR351c MEK1 ser/thr protein kinase YPL209c IPL1 ser/thr protein kinase YPR161c SGV1 ser/thr protein kinase YHR030c SLT2 ser/thr protein kinase of MAP kinase family YGR040w KSS1 ser/thr protein kinase of the MAP kinase family YJL095w BCK1 ser/thr protein kinase of the MEKK family YLR362w STE11 ser/thr protein kinase of the MEKK family YHL007c STE20 ser/thr protein kinase of the pheromone pathway YGR092w DBF2 ser/thr protein kinase related to DBF20P YHR102w KIC1 ser/thr protein kinase that interacts with CDC31P YKL101w HSL1 ser/thr protein kinase, coupling septin ring assembly to cell cycle progression YDL047w SIT4 ser/thr protein phosphatase YAL016w TPD3 ser/thr protein phosphatase 2A, regulatory chain A YKL048c ELM1 ser/thr-specific protein kinase YNL307c MCK1 ser/thr/tyr protein kinase YPL153c RAD53 ser/thr/tyr protein kinase YDL159w STE7 ser/thr/tyr protein kinase of MAP kinase kinase family YJL187c SWE1 ser/tyr dual-specifity protein kinase YIL095w PRK1 serine/threonine protein kinase involved in regulation of actin cytoskeleton organization YHR205w SCH9 serine/threonine protein kinase involved in stress response and nutrient-sensing signaling pathway YDL028c MPS1 serine/threonine/tyrosine protein kinase YBL052c SAS3 silencing protein YOL068c HST1 silencing protein YDR227w SIR4 silencing regulatory and DNA-repair protein YLR442c SIR3 silencing regulatory and DNA-repair protein YKR101w SIR1 silencing regulatory protein YDL042c SIR2 silencing regulatory protein and DNA-repair protein YLL003w SFI1 similarity to Xenopus laevis XCAP-C YJR138w IML1 similarity to C.elegans hypothetical protein T08A11.1 YNL246w similarity to D.melanogaster SET protein YNL218w similarity to E.coli hypothetical protein in serS 5'region YDR206w EBS1 similarity to EST1 protein YCR009c RVS161 similarity to human amphiphysin and RVS167P YAR003w FUN16 similarity to human RB protein binding protein YNL213c similarity to hypothetical protein Neurospora crassa YOR304c-a similarity to mouse apolipoprotein A-IV precursor YKL189w HYM1 similarity to mouse hypothetical calcium-binding protein and D.melanogaster Mo25 gene YOR077w RTS2 similarity to mouse KIN17 protein YDR409w similarity to NFI1P YKL179c similarity to NUF1P YHR146w CRP1 similarity to pheromone-response G-protein MDG1P YHR185c PFS1 similarity to S. pombe TEA1P YNL180c RHO5 similarity to S.pombe CDC42P and other GTP-binding proteins YOL034w similarity to S.pombe RAD18 and rpgL29 genes and other members of the SMC superfamily YMR262w similarity to S.pombe scn1 protein YLR356w similarity to SCM4 protein YLR179c similarity to TFS1P YIL036w CST6 similarity to YER045c YFR040w SAP155 SIT4P-associated protein YGL229c SAP4 SIT4P-associated protein YKR028w SAP190 SIT4P-associated protein YJL098w SAP185 SIT4P-associating protein YPL178w CBC2 small subunit of the nuclear cap-binding protein complex CBC YIL031w ULP2 SMT3P-specific protease, degrades conjugated ubiquitin-like protein SMT3P YGL086w MAD1 spindle assembly checkpoint protein YJR053w BFA1 spindle assembly checkpoint protein YMR198w CIK1 spindle pole body associated protein YDR356w NUF1 spindle pole body component YHR172w SPC97 spindle pole body component YKL042w SPC42 spindle pole body component YNL126w SPC98 spindle pole body component YOR257w CDC31 spindle pole body component, centrin YOL069w NUF2 spindle pole body protein YJL013c MAD3 spindle-assembly checkpoint protein YJL030w MAD2 spindle-assembly checkpoint protein YDR403w DIT1 spore wall maturation protein YBR148w YSW1 spore-specific protein YHR152w SPO12 sporulation protein YHR153c SPO16 sporulation protein YKL165c MCD4 sporulation protein YLR399c BDF1 sporulation protein YIL099w SGA1 sporulation specific glucan 1,4-alpha-glucosidase YDR108w GSG1 sporulation specific protein YER096w SHC1 sporulation specific protein YLR307w CDA1 sporulation-specific chitin deacetylase YLR308w CDA2 sporulation-specific chitin deacetylase YPR054w SMK1 sporulation-specific MAP kinase YDR522c SPS2 sporulation-specific protein YER115c SPR6 sporulation-specific protein YNL196c SLZ1 sporulation-specific protein YOR313c SPS4 sporulation-specific protein YGR059w SPR3 sporulation-specific septin YHR139c SPS100 sporulation-specific wall maturation protein YNL204c SPS18 sporulation-specific zinc-finger protein YKL113c RAD27 ssDNA endonuclease and 5'-3'exonuclease YCR028c-a RIM1 ssDNA-binding protein, mitochondrial YMR096w SNZ1 stationary phase protein YLR372w SUR4 sterol isomerase, fatty acid elongase YOR027w STI1 stress-induced protein YDR151c CTH1 strong similarity to CCCH zinc finger protein TIS11P YER066w strong similarity to cell division control protein CDC4P YBR210w strong similarity to D.melanogaster cornichon protein YLR117c CLF1 strong similarity to Drosophila putative cell cycle control protein crn YBR238c strong similarity to general chromatin factor SPT16P YPL032c SVL3 strong similarity to PAM1P YJL158c CIS3 strong similarity to PIR1P/HSP150P/PIR3P family YJL160c strong similarity to PIR1P/HSP150P/PIR3P family YGL056c SDS23 strong similarity to pombe SDS23 YLR215c CDC123 strong similarity to rat cell cycle progression related D123 protein YNL320w strong similarity to S.pombe Bem46 protein YKL161c (MLP1) strong similarity to ser/thr-specific protein kinase SLT2P YCL048w strong similarity to sporulation-specific protein SPS2P YDR055w PST1 strong similarity to SPS2 protein YBR161w strong similarity to SUR1P YJL078c PRY3 strong similarity to the plant PR-1 class of pathogen related proteins YJL079c PRY1 strong similarity to the plant PR-1 class of pathogen related proteins YDL224c WHI4 strong similarity to WHI3 protein YOL080c REX4 strong similarity to X.laevis XPMC2 protein and YGR276c YGR258c RAD2 structure-specific nuclease of the nucleotide excision repairosome YGL003c CDH1 substrate-specific activator of APC-dependent proteolysis YBL084c CDC27 subunit of anaphase-promoting complex (cyclosome) YFR036w CDC26 subunit of anaphase-promoting complex (cyclosome) YHR166c CDC23 subunit of anaphase-promoting complex (cyclosome) YKL022c CDC16 subunit of anaphase-promoting complex (cyclosome) YNL172w APC1 subunit of anaphase-promoting complex (cyclosome) YDR245w MNN10 subunit of mannosyltransferase complex YNR010w CSE2 subunit of RNA polymerase II mediator complex YDL008w APC11 subunit of the anaphase promoting complex YDR118w APC4 subunit of the anaphase promoting complex YLR102c APC9 subunit of the Anaphase Promoting Complex YMR263w SAP30 subunit of the histone deacetylase B complex YCR052w RSC6 subunit of the RSC complex YFR037c RSC8 subunit of the RSC complex YIL126w STH1 subunit of the RSC complex YLR321c SFH1 subunit of the RSC complex YOR213c SAS5 subunit of the RSC complex YJR091c JSN1 suppresses the high-temperature lethality of TUB2-150 YDR099w BMH2 suppressor of clathrin deficiency YOR057w SGT1 suppressor of G2 allele of SKP1 YER167w BCK2 suppressor of mutations in protein kinase C pathway components YJR075w HOC1 suppressor of PKC1 YDR285w ZIP1 synaptonemal complex protein YOR075w UFE1 syntaxin (T-SNARE) of the ER YDR416w SYF1 synthetic lethal with CDC40 YLR233c EST1 telomere elongation protein YBL088c TEL1 telomere length control protein YPL129w ANC1 TFIIF subunit (transcription initiation factor), 30 kD YPR025c CCL1 TFIIH subunit (transcription initiation factor), cyclin C component YGL043w DST1 TFIIS (transcription elongation factor) YLR043c TRX1 thioredoxin I YGR209c TRX2 thioredoxin II YNL273w TOF1 topoisomerase I interacting factor 1 YOL115w TRF4 topoisomerase I-related protein YCR077c PAT1 topoisomerase II-associated protein YGR063c SPT4 transcription elongation protein YGR116w SPT6 transcription elongation protein YDL165w CDC36 transcription factor YDR146c SWI5 transcription factor YER111c SWI4 transcription factor YKL043w PHD1 transcription factor YLR182w SWI6 transcription factor YGL181w GTS1 transcription factor of the GCS1P/GLO3P/SPS18P family YMR043w MCM1 transcription factor of the MADS box family YJR094c IME1 transcription factor required for sporulation YHR206w SKN7 transcription factor with similarity to HSF1P YDL056w MBP1 transcription factor, subunit of the MBF factor YJL176c SWI3 transcription regulatory protein YOL004w SIN3 transcription regulatory protein YHR084w STE12 transcriptional activator YOR028c CIN5 transcriptional activator YIL084c SDS3 transcriptional regulator YNL012w SPO1 transcriptional regulator involved in sporulation YER068w MOT2 transcriptional repressor YBR079c RPG1 translation initiation factor eIF3 (p110 subunit) YOR361c PRT1 translation initiation factor eIF3 subunit YOL139c CDC33 translation initiation factor eIF4E YNL079c TPM1 tropomyosin 1 YIL138c TPM2 tropomyosin, isoform 2 YGR080w TWF1 twinfilin, an actin monomer sequestering protein YBR083w TEC1 Ty transcription activator YBR015c MNN2 type II membrane protein YOR219c STE13 type IV dipeptidyl aminopeptidase YHR165c PRP8 U5 snRNP protein, pre-mRNA splicing factor YLL039c UBI4 ubiquitin YMR276w DSK2 ubiquitin-like protein YDR069c DOA4 ubiquitin-specific protease YBR243c ALG7 UDP-N-acetylglucosamine-1-phosphate transferase YML021c UNG1 uracil-DNA glycosylase YGL095c VPS45 vacuolar protein sorting-associated protein YML115c VAN1 vanadate resistance protein YLR337c VRP1 verprolin YIL049w DFG10 weak similarity to C.elegans hypothetical protein F42F12.3 YJL065c weak similarity to DNA-directed DNA polymerase II chain C YPL126w NAN1 weak similarity to fruit fly TFIID subunit p85 YJL170c ASG7 weak similarity to Helicobacter pylori endonuclease III YIL073c SPO22 weak similarity to mouse polycystic kidney disease-related protein YBR107c IML3 weak similarity to N.crassa chitin synthase YOR281c PLP2 weak similarity to phosducins YDL114w weak similarity to Rhizobium nodulation protein nodG YDR130c FIN1 weak similarity to sea urchin myosin heavy chain YJR046w TAH11 weak similarity to Xenopus vimentin 4 YDR545w YRF1-1 Y'-helicase protein 1 YER190w YRF1-2 Y'-helicase protein 1 YDR325w YCG1 Yeast Condensin G YMR241w YHM2 yeast suppressor gene of HM (mitochondrial histone) mutant (ABF2) YER122c GLO3 zinc finger protein YLR403w SFP1 zinc finger protein YJR117w STE24 zinc metallo-protease YGR044c RME1 zinc-finger transcription factor
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