Saccharomyces cerevisiae - Functional Catalogue   cell cycle control and mitosis (348 ORFs) YPL268w PLC1 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase YER177w BMH1 14-3-3 protein involved in rapamycin-sensitive signalling YPR103w PRE2 20S proteasome subunit (beta5) YFR052w RPN12 26S proteasome regulatory subunit YGL048c RPT6 26S proteasome regulatory subunit YKL145w RPT1 26S proteasome regulatory subunit YOL021c DIS3 3'->5' exoribonuclease required for 3' end formation of 5.8S rRNA YLR075w RPL10 60S large subunit ribosomal protein YFL039c ACT1 actin YBR211c AME1 actin related protein YBR133c HSL7 adapter in a regulatory pathway that relieves tyrosine phosphorylation of CDC28 YJL005w CYR1 adenylate cyclase YDL226c GCS1 ADP-ribosylation factor GTPase-activating protein (ARF-GAP) YML085c TUB1 alpha-1 tubulin YML124c TUB3 alpha-3 tubulin YPL239w YAR1 ankyrin repeat-containing protein YFL037w TUB2 beta-tubulin YHR101c BIG1 big cells phenotype YER016w BIM1 binding to microtubules YHR208w BAT1 branched chain amino acid aminotransferase, mitochondrial YBR200w BEM1 bud emergence mediator YGR230w BNS1 Bypasses Need for SPO12P YLR248w RCK2 Ca/calmodulin-dependent ser/thr protein kinase YBR109c CMD1 calmodulin YOR061w CKA2 casein kinase II alpha' chain YIL035c CKA1 casein kinase II, catalytic alpha chain YER123w YCK3 casein kinase, isoform 3 YLR178c TFS1 CDC25-dependent nutrient- and ammonia-response cell-cycle regulator YGR049w SCM4 CDC4 suppressor YFL029c CAK1 cdk-activating protein kinase YMR055c BUB2 cell cycle arrest protein YOR026w BUB3 cell cycle arrest protein YBR136w MEC1 cell cycle checkpoint protein YDR499w LCD1 cell cycle checkpoint protein YER173w RAD24 cell cycle checkpoint protein YPR111w DBF20 cell cycle protein kinase related to DBF2P YDR113c PDS1 cell cycle regulator YBR215w HPC2 cell cycle regulatory protein YOR373w NUD1 cell cycle regulatory protein YBR202w CDC47 cell division control protein YCR002c CDC10 cell division control protein YDL220c CDC13 cell division control protein YDR168w CDC37 cell division control protein YDR182w CDC1 cell division control protein YDR364c CDC40 cell division control protein YFL009w CDC4 cell division control protein YGL116w CDC20 cell division control protein YJL194w CDC6 cell division control protein YLR274w CDC46 cell division control protein YLR314c CDC3 cell division control protein YNL188w KAR1 cell division control protein YPL255w BBP1 cell division control protein YCR094w CDC50 cell division cycle mutant YNL327w EGT2 cell-cycle regulation protein YHR129c ARP1 centractin YDR254w CHL4 chromosome segregation protein YFL008w SMC1 chromosome segregation protein YFR031c SMC2 chromosome segregation protein YOR349w CIN1 chromosome segregation protein YGL240w DOC1 component of the anaphase promoting complex YLR127c APC2 component of the anaphase promoting complex YOR249c APC5 component of the anaphase-promoting complex YKL049c CSE4 component of the core centromere YPL174c NIP100 component of the dynactin complex YMR028w TAP42 component of the Tor signaling pathway YDL132w CDC53 controls G1/S transition YPL269w KAR9 cortical protein required for cytoplasmic microtubule orientation and nuclear migration YGR109c CLB6 cyclin, B-type YPR120c CLB5 cyclin, B-type YAL040c CLN3 cyclin, G1/S-specific YDL127w PCL2 cyclin, G1/S-specific YMR199w CLN1 cyclin, G1/S-specific YNL289w PCL1 cyclin, G1/S-specific YPL256c CLN2 cyclin, G1/S-specific YDL155w CLB3 cyclin, G2/M-specific YGR108w CLB1 cyclin, G2/M-specific YLR210w CLB4 cyclin, G2/M-specific YPR119w CLB2 cyclin, G2/M-specific YJL157c FAR1 cyclin-dependent kinase inhibitor (CKI) YBR135w CKS1 cyclin-dependent kinases regulatory subunit YBR160w CDC28 cyclin-dependent protein kinase YPL031c PHO85 cyclin-dependent protein kinase YDL108w KIN28 cyclin-dependent ser/thr protein kinase YGL215w CLG1 cyclin-like protein YLR226w BUR2 divergent CDK-cyclin complex YOR368w RAD17 DNA damage checkpoint control protein YPL194w DDC1 DNA damage checkpoint protein YKL017c HCS1 DNA helicase A YMR224c MRE11 DNA repair and meiotic recombination protein YDR217c RAD9 DNA repair checkpoint protein YBR087w RFC5 DNA replication factor C, 40 KD subunit YJR068w RFC2 DNA replication factor C, 41 KD subunit YOR217w RFC1 DNA replication factor C, 95 KD subunit YLR234w TOP3 DNA topoisomerase III YNL216w RAP1 DNA-binding protein with repressor and activator activity YNL262w POL2 DNA-directed DNA polymerase epsilon, catalytic subunit A YLR129w DIP2 DOM34P-interacting protein YFR028c CDC14 dual specificity phosphatase YNL053w MSG5 dual-specifity protein phosphatase YKR054c DYN1 dynein heavy chain, cytosolic YDL064w UBC9 E2 ubiquitin-conjugating enzyme YDR054c CDC34 E2 ubiquitin-conjugating enzyme YDR457w TOM1 E3 ubiqitin ligase required for G2/M transition YFL017c GNA1 essential acetyltransferase YDR172w SUP35 eukaryotic peptide chain release factor GTP-binding subunit YBL097w BRN1 functional homologue of human BRRN1 YNL001w DOM34 functions in protein translation to promote G1 progression and differentiation YIR024c GIF1 G1 Factor needed for normal G1 phase YLR288c MEC3 G2-specific checkpoint protein YLR212c TUB4 gamma tubulin YLR299w ECM38 gamma-glutamyltransferase, involved in glutathione synthesis YAL024c LTE1 GDP/GTP exchange factor YLL016w SDC25 GDP/GTP exchange factor (GEF) YLR310c CDC25 GDP/GTP exchange factor for RAS1P and RAS2P YGL207w SPT16 general chromatin factor YGL155w CDC43 geranylgeranyltransferase beta subunit YNL153c GIM3 Gim complex component YGR078c PAC10 GIM4 - Gim complex component YMR138w CIN4 GTP-binding protein YNL098c RAS2 GTP-binding protein YLR229c CDC42 GTP-binding protein of RAS superfamily YML064c TEM1 GTP-binding protein of the RAS superfamily YAL041w CDC24 GTP/GDP exchange factor for CDC42P YER155c BEM2 GTPase-activating protein YNL007c SIS1 heat shock protein YGL073w HSF1 heat shock transcription factor YOR156c NFI1 interacts with CDC12P in 2-hybrid assay YML104c MDM1 intermediate filament protein YIL123w SIM1 involved in cell cycle regulation and aging YJR140c HIR3 involved in cell cycle regulation of histone transcription YKR072c SIS2 involved in cell cycle-specific gene expression YKR063c LAS1 involved in cell morphogenesis, cytoskeletal regulation and bud formation YHR119w SET1 involved in chromatin-mediated gene regulation YPL018w CTF19 involved in chromosome segregation YPL241c CIN2 involved in chromosome segregation YPR046w MCM16 involved in chromosome segregation YOR195w SLK19 involved in control of spindle dynamics together with KAR3P YNL225c CNM67 involved in cytokinesis YJL090c DPB11 involved in DNA replication and S-phase checkpoint YMR273c ZDS1 involved in negative regulation of cell polarity YCR086w CSM1 involved in nuclear migration YMR052w FAR3 involved in pheromone-mediated cell cycle arrest YMR001c CDC5 involved in regulation of DNA replication YIL046w MET30 involved in regulation of sulfur assimilation genes and cell cycle progression YMR127c SAS2 involved in silencing at HMR YDR180w SCC2 involved in sister chromatid cohesion YFR027w ECO1 involved in sister chromatid cohesion during replication YDR022c CIS1 involved in suppression of CIK1 mutation YDR082w STN1 involved in telomere length regulation YKR042w UTH1 involved in the aging process YER007w PAC2 involved in the stabilization of microtubles YDR293c SSD1 involved in the tolerance to high concentration of Ca2+ YCL024w KCC4 kinase coordinate cell cycle progression with the organization of the peripheralcytoskeleton YBL063w KIP1 kinesin-related protein YEL061c CIN8 kinesin-related protein YPL155c KIP2 kinesin-related protein YPR141c KAR3 kinesin-related protein YGL216w KIP3 kinesin-related protein required for nuclear migration YJR060w CBF1 kinetochore protein YGR140w CBF2 kinetochore protein complex CBF3, 110 KD subunit YDR328c SKP1 kinetochore protein complex CBF3, subunit D YMR168c CEP3 kinetochore protein complex, 71 KD subunit YMR094w CTF13 kinetochore protein complex, CBF3, 58 KD subunit YMR036c MIH1 M-phase inducing protein tyrosine phosphatase YOR198c BFR1 maintenance of normal ploidy YLR332w MID2 mating process protein YLL017w maybe part of SCD25 YHR079c-a SAE3 meiosis specific protein YER179w DMC1 meiosis-specific protein YPR019w CDC54 member of the CDC46P/MCM2P/MCM3P family YDL126c CDC48 microsomal protein of CDC48/PAS1/SEC18 family of ATPases YOR058c ASE1 microtubule-associated protein (nonmotor) YOR272w YTM1 microtubule-interacting protein YNL064c YDJ1 mitochondrial and ER import protein YGR029w ERV1 mitochondrial biogenesis and regulation of cell cycle YBL016w FUS3 mitogen-activated protein kinase (MAP kinase) YMR294w JNM1 mitosis protein, involved in nuclear migration YDL003w MCD1 Mitotic Chromosome Determinant YBR156c SLI15 Mitotic spindle protein involved in chromosome segregation YGL178w MPT5 multicopy suppressor of POP2 YML109w ZDS2 multicopy suppressor of SIN4 YGL173c KEM1 multifunctional nuclease YMR200w ROT1 mutant suppresses TOR2 mutation YOL076w MDM20 necessary for mitochondrial inheritance and organisation of the actin cytoskeleton YDR207c UME6 negative transcriptional regulator YBL020w RFT1 nuclear division protein YNL299w TRF5 nuclear division protein YJR112w NNF1 nuclear envelope protein YML031w NDC1 nuclear envelope protein YCL029c BIK1 nuclear fusion protein YJL034w KAR2 nuclear fusion protein YDR150w NUM1 nuclear migration protein YAL025c MAK16 nuclear viral propagation protein YKR048c NAP1 nucleosome assembly protein I YEL037c RAD23 nucleotide excision repair protein (ubiquitin-like protein) YLR079w SIC1 p40 inhibitor of CDC28P-Clb protein kinase complex YCL016c DCC1 part of an alternative RFC complex YCL004w PGS1 phosphatidylglycerophosphate synthase YJR066w TOR1 phosphatidylinositol 3-kinase YKL203c TOR2 phosphatidylinositol 3-kinase YLR305c STT4 phosphatidylinositol-4-kinase YGR023w MTL1 potential cell wall stres sensor YBL058w SHP1 potential regulatory subunit for GLC7P YGR231c PHB2 Prohibitin YGR132c PHB1 prohibitin, antiproliferative protein YDL017w CDC7 protein kinase YOR149c SMP3 protein kinase C pathway protein YPL140c MKK2 protein kinase of the map kinase kinase (MEK) family YAR019c CDC15 protein kinase of the MAP kinase kinase kinase family YHR013c ARD1 protein N-acetyltransferase subunit YPL008w CHL1 protein of the DEAH box family YGL075c MPS2 Protein of the nuclear envelope/endoplasmic reticulum required for spindle pole body assembly and normal chromosome segregation YOR372c NDD1 protein required for nuclear division YDL134c PPH21 protein ser/thr phosphatase PP2A-1 YDL188c PPH22 protein ser/thr phosphatase PP2A-2 YBR276c PPS1 protein tyrosine phosphatase YER075c PTP3 protein tyrosine phosphatase YNL292w PUS4 pseudouridine synthase YBR186w PCH2 putative ATPase YDR440w DOT1 putative ATPase YLR175w CBF5 putative rRNA pseuduridine synthase YDR137w RGP1 reduced growth phenotype protein YDR363w-a SEM1 regulator of exocytosis and pseudohyphal differentiation YCL055w KAR4 regulatory protein required for pheromone induction of karyogamy genes YDR052c DBF4 regulatory subunit for CDC7P protein kinase YKL193c SDS22 regulatory subunit for the mitotic function of type I protein phosphatase YBR274w CHK1 regulats inhibitory Cdk phosphorylation of PDS1 YMR213w CEF1 required during G2/M transition YMR078c CTF18 required for accurate chromosome transmission in mitosis and maintenance of normal telomere length YIL106w MOB1 required for completion of mitosis and maintenance of ploidy YOL145c CTR9 required for G1 cyclin expression YJR090c GRR1 required for glucose repression and for glucose and cation transport YJL080c SCP160 required for maintenance of exact ploidy YLR103c CDC45 required for minichromosome maintenance and initiation of chromosomal DNA replication YPR082c DIB1 required for mitosis YKL089w MIF2 required for normal chromosome segregation and spindle integrity YIL150c DNA43 required for S-phase initiation or completion YGR098c ESP1 required for sister chromatid separation YJL074c SMC3 required for structural maintenance of chromosomes YDR488c PAC11 required in the absence of CIN8P YDL225w SHS1 septin YHR107c CDC12 septin YJR076c CDC11 septin YGL190c CDC55 ser/thr phosphatase 2A regulatory subunit B YER133w GLC7 ser/thr phosphoprotein phosphatase 1, catalytic chain YBL105c PKC1 ser/thr protein kinase YDR507c GIN4 ser/thr protein kinase YGL158w RCK1 ser/thr protein kinase YGR188c BUB1 ser/thr protein kinase YJL106w IME2 ser/thr protein kinase YJL141c YAK1 ser/thr protein kinase YMR104c YPK2 ser/thr protein kinase YOR231w MKK1 ser/thr protein kinase YPL209c IPL1 ser/thr protein kinase YPR161c SGV1 ser/thr protein kinase YHR030c SLT2 ser/thr protein kinase of MAP kinase family YJL095w BCK1 ser/thr protein kinase of the MEKK family YGR092w DBF2 ser/thr protein kinase related to DBF20P YHR102w KIC1 ser/thr protein kinase that interacts with CDC31P YKL101w HSL1 ser/thr protein kinase, coupling septin ring assembly to cell cycle progression YDL047w SIT4 ser/thr protein phosphatase YAL016w TPD3 ser/thr protein phosphatase 2A, regulatory chain A YKL048c ELM1 ser/thr-specific protein kinase YNL307c MCK1 ser/thr/tyr protein kinase YPL153c RAD53 ser/thr/tyr protein kinase YJL187c SWE1 ser/tyr dual-specifity protein kinase YIL095w PRK1 serine/threonine protein kinase involved in regulation of actin cytoskeleton organization YHR205w SCH9 serine/threonine protein kinase involved in stress response and nutrient-sensing signaling pathway YDL028c MPS1 serine/threonine/tyrosine protein kinase YLL003w SFI1 similarity to Xenopus laevis XCAP-C YNL246w similarity to D.melanogaster SET protein YAR003w FUN16 similarity to human RB protein binding protein YKL179c similarity to NUF1P YMR262w similarity to S.pombe scn1 protein YLR356w similarity to SCM4 protein YLR179c similarity to TFS1P YFR040w SAP155 SIT4P-associated protein YGL229c SAP4 SIT4P-associated protein YKR028w SAP190 SIT4P-associated protein YJL098w SAP185 SIT4P-associating protein YPL178w CBC2 small subunit of the nuclear cap-binding protein complex CBC YIL031w ULP2 SMT3P-specific protease, degrades conjugated ubiquitin-like protein SMT3P YGL086w MAD1 spindle assembly checkpoint protein YJR053w BFA1 spindle assembly checkpoint protein YMR198w CIK1 spindle pole body associated protein YDR356w NUF1 spindle pole body component YHR172w SPC97 spindle pole body component YKL042w SPC42 spindle pole body component YNL126w SPC98 spindle pole body component YOR257w CDC31 spindle pole body component, centrin YOL069w NUF2 spindle pole body protein YJL013c MAD3 spindle-assembly checkpoint protein YJL030w MAD2 spindle-assembly checkpoint protein YER066w strong similarity to cell division control protein CDC4P YLR117c CLF1 strong similarity to Drosophila putative cell cycle control protein crn YBR238c strong similarity to general chromatin factor SPT16P YGL056c SDS23 strong similarity to pombe SDS23 YLR215c CDC123 strong similarity to rat cell cycle progression related D123 protein YKL161c (MLP1) strong similarity to ser/thr-specific protein kinase SLT2P YOL080c REX4 strong similarity to X.laevis XPMC2 protein and YGR276c YGL003c CDH1 substrate-specific activator of APC-dependent proteolysis YBL084c CDC27 subunit of anaphase-promoting complex (cyclosome) YFR036w CDC26 subunit of anaphase-promoting complex (cyclosome) YHR166c CDC23 subunit of anaphase-promoting complex (cyclosome) YKL022c CDC16 subunit of anaphase-promoting complex (cyclosome) YNL172w APC1 subunit of anaphase-promoting complex (cyclosome) YNR010w CSE2 subunit of RNA polymerase II mediator complex YDL008w APC11 subunit of the anaphase promoting complex YDR118w APC4 subunit of the anaphase promoting complex YLR102c APC9 subunit of the Anaphase Promoting Complex YCR052w RSC6 subunit of the RSC complex YFR037c RSC8 subunit of the RSC complex YIL126w STH1 subunit of the RSC complex YLR321c SFH1 subunit of the RSC complex YOR213c SAS5 subunit of the RSC complex YJR091c JSN1 suppresses the high-temperature lethality of TUB2-150 YDR099w BMH2 suppressor of clathrin deficiency YOR057w SGT1 suppressor of G2 allele of SKP1 YER167w BCK2 suppressor of mutations in protein kinase C pathway components YDR285w ZIP1 synaptonemal complex protein YDR416w SYF1 synthetic lethal with CDC40 YBL088c TEL1 telomere length control protein YPL129w ANC1 TFIIF subunit (transcription initiation factor), 30 kD YPR025c CCL1 TFIIH subunit (transcription initiation factor), cyclin C component YLR043c TRX1 thioredoxin I YGR209c TRX2 thioredoxin II YOL115w TRF4 topoisomerase I-related protein YDL165w CDC36 transcription factor YER111c SWI4 transcription factor YLR182w SWI6 transcription factor YGL181w GTS1 transcription factor of the GCS1P/GLO3P/SPS18P family YMR043w MCM1 transcription factor of the MADS box family YHR206w SKN7 transcription factor with similarity to HSF1P YDL056w MBP1 transcription factor, subunit of the MBF factor YOR028c CIN5 transcriptional activator YNL012w SPO1 transcriptional regulator involved in sporulation YBR079c RPG1 translation initiation factor eIF3 (p110 subunit) YOR361c PRT1 translation initiation factor eIF3 subunit YHR165c PRP8 U5 snRNP protein, pre-mRNA splicing factor YMR276w DSK2 ubiquitin-like protein YBR243c ALG7 UDP-N-acetylglucosamine-1-phosphate transferase YML115c VAN1 vanadate resistance protein YPL126w NAN1 weak similarity to fruit fly TFIID subunit p85 YBR107c IML3 weak similarity to N.crassa chitin synthase YDR130c FIN1 weak similarity to sea urchin myosin heavy chain YER122c GLO3 zinc finger protein YLR403w SFP1 zinc finger protein YGR044c RME1 zinc-finger transcription factor Back to MIPS Yeast Functional Categories Page. 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