Saccharomyces cerevisiae -
Functional Catalogue

mips


 

cell cycle control and mitosis (348 ORFs)

YPL268w     PLC1     1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
YER177w     BMH1     14-3-3 protein involved in rapamycin-sensitive signalling
YPR103w     PRE2     20S proteasome subunit (beta5)
YFR052w     RPN12    26S proteasome regulatory subunit
YGL048c     RPT6     26S proteasome regulatory subunit
YKL145w     RPT1     26S proteasome regulatory subunit
YOL021c     DIS3     3'->5' exoribonuclease required for 3' end formation of 5.8S rRNA
YLR075w     RPL10    60S large subunit ribosomal protein
YFL039c     ACT1     actin
YBR211c     AME1     actin related protein
YBR133c     HSL7     adapter in a regulatory pathway that relieves tyrosine phosphorylation of CDC28
YJL005w     CYR1     adenylate cyclase
YDL226c     GCS1     ADP-ribosylation factor GTPase-activating protein (ARF-GAP)
YML085c     TUB1     alpha-1 tubulin
YML124c     TUB3     alpha-3 tubulin
YPL239w     YAR1     ankyrin repeat-containing protein
YFL037w     TUB2     beta-tubulin
YHR101c     BIG1     big cells phenotype
YER016w     BIM1     binding to microtubules
YHR208w     BAT1     branched chain amino acid aminotransferase, mitochondrial
YBR200w     BEM1     bud emergence mediator
YGR230w     BNS1     Bypasses Need for SPO12P
YLR248w     RCK2     Ca/calmodulin-dependent ser/thr protein kinase
YBR109c     CMD1     calmodulin
YOR061w     CKA2     casein kinase II alpha' chain
YIL035c     CKA1     casein kinase II, catalytic alpha chain
YER123w     YCK3     casein kinase, isoform 3
YLR178c     TFS1     CDC25-dependent nutrient- and ammonia-response cell-cycle regulator
YGR049w     SCM4     CDC4 suppressor
YFL029c     CAK1     cdk-activating protein kinase
YMR055c     BUB2     cell cycle arrest protein
YOR026w     BUB3     cell cycle arrest protein
YBR136w     MEC1     cell cycle checkpoint protein
YDR499w     LCD1     cell cycle checkpoint protein
YER173w     RAD24    cell cycle checkpoint protein
YPR111w     DBF20    cell cycle protein kinase related to DBF2P
YDR113c     PDS1     cell cycle regulator
YBR215w     HPC2     cell cycle regulatory protein
YOR373w     NUD1     cell cycle regulatory protein
YBR202w     CDC47    cell division control protein
YCR002c     CDC10    cell division control protein
YDL220c     CDC13    cell division control protein
YDR168w     CDC37    cell division control protein
YDR182w     CDC1     cell division control protein
YDR364c     CDC40    cell division control protein
YFL009w     CDC4     cell division control protein
YGL116w     CDC20    cell division control protein
YJL194w     CDC6     cell division control protein
YLR274w     CDC46    cell division control protein
YLR314c     CDC3     cell division control protein
YNL188w     KAR1     cell division control protein
YPL255w     BBP1     cell division control protein
YCR094w     CDC50    cell division cycle mutant
YNL327w     EGT2     cell-cycle regulation protein
YHR129c     ARP1     centractin
YDR254w     CHL4     chromosome segregation protein
YFL008w     SMC1     chromosome segregation protein
YFR031c     SMC2     chromosome segregation protein
YOR349w     CIN1     chromosome segregation protein
YGL240w     DOC1     component of the anaphase promoting complex
YLR127c     APC2     component of the anaphase promoting complex
YOR249c     APC5     component of the anaphase-promoting complex
YKL049c     CSE4     component of the core centromere
YPL174c     NIP100   component of the dynactin complex
YMR028w     TAP42    component of the Tor signaling pathway
YDL132w     CDC53    controls G1/S transition
YPL269w     KAR9     cortical protein required for cytoplasmic microtubule orientation and nuclear migration
YGR109c     CLB6     cyclin, B-type
YPR120c     CLB5     cyclin, B-type
YAL040c     CLN3     cyclin, G1/S-specific
YDL127w     PCL2     cyclin, G1/S-specific
YMR199w     CLN1     cyclin, G1/S-specific
YNL289w     PCL1     cyclin, G1/S-specific
YPL256c     CLN2     cyclin, G1/S-specific
YDL155w     CLB3     cyclin, G2/M-specific
YGR108w     CLB1     cyclin, G2/M-specific
YLR210w     CLB4     cyclin, G2/M-specific
YPR119w     CLB2     cyclin, G2/M-specific
YJL157c     FAR1     cyclin-dependent kinase inhibitor (CKI)
YBR135w     CKS1     cyclin-dependent kinases regulatory subunit
YBR160w     CDC28    cyclin-dependent protein kinase
YPL031c     PHO85    cyclin-dependent protein kinase
YDL108w     KIN28    cyclin-dependent ser/thr protein kinase
YGL215w     CLG1     cyclin-like protein
YLR226w     BUR2     divergent CDK-cyclin complex
YOR368w     RAD17    DNA damage checkpoint control protein
YPL194w     DDC1     DNA damage checkpoint protein
YKL017c     HCS1     DNA helicase A
YMR224c     MRE11    DNA repair and meiotic recombination protein
YDR217c     RAD9     DNA repair checkpoint protein
YBR087w     RFC5     DNA replication factor C, 40 KD subunit
YJR068w     RFC2     DNA replication factor C, 41 KD subunit
YOR217w     RFC1     DNA replication factor C, 95 KD subunit
YLR234w     TOP3     DNA topoisomerase III
YNL216w     RAP1     DNA-binding protein with repressor and activator activity
YNL262w     POL2     DNA-directed DNA polymerase epsilon, catalytic subunit A
YLR129w     DIP2     DOM34P-interacting protein
YFR028c     CDC14    dual specificity phosphatase
YNL053w     MSG5     dual-specifity protein phosphatase
YKR054c     DYN1     dynein heavy chain, cytosolic
YDL064w     UBC9     E2 ubiquitin-conjugating enzyme
YDR054c     CDC34    E2 ubiquitin-conjugating enzyme
YDR457w     TOM1     E3 ubiqitin ligase required for G2/M transition
YFL017c     GNA1     essential acetyltransferase
YDR172w     SUP35    eukaryotic peptide chain release factor GTP-binding subunit
YBL097w     BRN1     functional homologue of human BRRN1
YNL001w     DOM34    functions in protein translation to promote G1 progression and differentiation
YIR024c     GIF1     G1 Factor needed for normal G1 phase
YLR288c     MEC3     G2-specific checkpoint protein
YLR212c     TUB4     gamma tubulin
YLR299w     ECM38    gamma-glutamyltransferase, involved in glutathione synthesis
YAL024c     LTE1     GDP/GTP exchange factor
YLL016w     SDC25    GDP/GTP exchange factor (GEF)
YLR310c     CDC25    GDP/GTP exchange factor for RAS1P and RAS2P
YGL207w     SPT16    general chromatin factor
YGL155w     CDC43    geranylgeranyltransferase beta subunit
YNL153c     GIM3     Gim complex component
YGR078c     PAC10    GIM4 - Gim complex component
YMR138w     CIN4     GTP-binding protein
YNL098c     RAS2     GTP-binding protein
YLR229c     CDC42    GTP-binding protein of RAS superfamily
YML064c     TEM1     GTP-binding protein of the RAS superfamily
YAL041w     CDC24    GTP/GDP exchange factor for CDC42P
YER155c     BEM2     GTPase-activating protein
YNL007c     SIS1     heat shock protein
YGL073w     HSF1     heat shock transcription factor
YOR156c     NFI1     interacts with CDC12P in 2-hybrid assay
YML104c     MDM1     intermediate filament protein
YIL123w     SIM1     involved in cell cycle regulation and aging
YJR140c     HIR3     involved in cell cycle regulation of histone transcription
YKR072c     SIS2     involved in cell cycle-specific gene expression
YKR063c     LAS1     involved in cell morphogenesis, cytoskeletal regulation and bud formation
YHR119w     SET1     involved in chromatin-mediated gene regulation
YPL018w     CTF19    involved in chromosome segregation
YPL241c     CIN2     involved in chromosome segregation
YPR046w     MCM16    involved in chromosome segregation
YOR195w     SLK19    involved in control of spindle dynamics together with KAR3P
YNL225c     CNM67    involved in cytokinesis
YJL090c     DPB11    involved in DNA replication and S-phase checkpoint
YMR273c     ZDS1     involved in negative regulation of cell polarity
YCR086w     CSM1     involved in nuclear migration
YMR052w     FAR3     involved in pheromone-mediated cell cycle arrest
YMR001c     CDC5     involved in regulation of DNA replication
YIL046w     MET30    involved in regulation of sulfur assimilation genes and cell cycle progression
YMR127c     SAS2     involved in silencing at HMR
YDR180w     SCC2     involved in sister chromatid cohesion
YFR027w     ECO1     involved in sister chromatid cohesion during replication
YDR022c     CIS1     involved in suppression of CIK1 mutation
YDR082w     STN1     involved in telomere length regulation
YKR042w     UTH1     involved in the aging process
YER007w     PAC2     involved in the stabilization of microtubles
YDR293c     SSD1     involved in the tolerance to high concentration of Ca2+
YCL024w     KCC4     kinase coordinate cell cycle progression with the organization of the peripheralcytoskeleton
YBL063w     KIP1     kinesin-related protein
YEL061c     CIN8     kinesin-related protein
YPL155c     KIP2     kinesin-related protein
YPR141c     KAR3     kinesin-related protein
YGL216w     KIP3     kinesin-related protein required for nuclear migration
YJR060w     CBF1     kinetochore protein
YGR140w     CBF2     kinetochore protein complex CBF3, 110 KD subunit
YDR328c     SKP1     kinetochore protein complex CBF3, subunit D
YMR168c     CEP3     kinetochore protein complex, 71 KD subunit
YMR094w     CTF13    kinetochore protein complex, CBF3, 58 KD subunit
YMR036c     MIH1     M-phase inducing protein tyrosine phosphatase
YOR198c     BFR1     maintenance of normal ploidy
YLR332w     MID2     mating process protein
YLL017w              maybe part of SCD25
YHR079c-a   SAE3     meiosis specific protein
YER179w     DMC1     meiosis-specific protein
YPR019w     CDC54    member of the CDC46P/MCM2P/MCM3P family
YDL126c     CDC48    microsomal protein of CDC48/PAS1/SEC18 family of ATPases
YOR058c     ASE1     microtubule-associated protein (nonmotor)
YOR272w     YTM1     microtubule-interacting protein
YNL064c     YDJ1     mitochondrial and ER import protein
YGR029w     ERV1     mitochondrial biogenesis and regulation of cell cycle
YBL016w     FUS3     mitogen-activated protein kinase (MAP kinase)
YMR294w     JNM1     mitosis protein, involved in nuclear migration
YDL003w     MCD1     Mitotic Chromosome Determinant
YBR156c     SLI15    Mitotic spindle protein involved in chromosome segregation
YGL178w     MPT5     multicopy suppressor of POP2
YML109w     ZDS2     multicopy suppressor of SIN4
YGL173c     KEM1     multifunctional nuclease
YMR200w     ROT1     mutant suppresses TOR2 mutation
YOL076w     MDM20    necessary for mitochondrial inheritance and organisation of the actin cytoskeleton
YDR207c     UME6     negative transcriptional regulator
YBL020w     RFT1     nuclear division protein
YNL299w     TRF5     nuclear division protein
YJR112w     NNF1     nuclear envelope protein
YML031w     NDC1     nuclear envelope protein
YCL029c     BIK1     nuclear fusion protein
YJL034w     KAR2     nuclear fusion protein
YDR150w     NUM1     nuclear migration protein
YAL025c     MAK16    nuclear viral propagation protein
YKR048c     NAP1     nucleosome assembly protein I
YEL037c     RAD23    nucleotide excision repair protein (ubiquitin-like protein)
YLR079w     SIC1     p40 inhibitor of CDC28P-Clb protein kinase complex
YCL016c     DCC1     part of an alternative RFC complex
YCL004w     PGS1     phosphatidylglycerophosphate synthase
YJR066w     TOR1     phosphatidylinositol 3-kinase
YKL203c     TOR2     phosphatidylinositol 3-kinase
YLR305c     STT4     phosphatidylinositol-4-kinase
YGR023w     MTL1     potential cell wall stres sensor
YBL058w     SHP1     potential regulatory subunit for GLC7P
YGR231c     PHB2     Prohibitin
YGR132c     PHB1     prohibitin, antiproliferative protein
YDL017w     CDC7     protein kinase
YOR149c     SMP3     protein kinase C pathway protein
YPL140c     MKK2     protein kinase of the map kinase kinase (MEK) family
YAR019c     CDC15    protein kinase of the MAP kinase kinase kinase family
YHR013c     ARD1     protein N-acetyltransferase subunit
YPL008w     CHL1     protein of the DEAH box family
YGL075c     MPS2     Protein of the nuclear envelope/endoplasmic reticulum required for spindle pole body assembly and normal chromosome segregation
YOR372c     NDD1     protein required for nuclear division
YDL134c     PPH21    protein ser/thr phosphatase PP2A-1
YDL188c     PPH22    protein ser/thr phosphatase PP2A-2
YBR276c     PPS1     protein tyrosine phosphatase
YER075c     PTP3     protein tyrosine phosphatase
YNL292w     PUS4     pseudouridine synthase
YBR186w     PCH2     putative ATPase
YDR440w     DOT1     putative ATPase
YLR175w     CBF5     putative rRNA pseuduridine synthase
YDR137w     RGP1     reduced growth phenotype protein
YDR363w-a   SEM1     regulator of exocytosis and pseudohyphal differentiation
YCL055w     KAR4     regulatory protein required for pheromone induction of karyogamy genes
YDR052c     DBF4     regulatory subunit for CDC7P protein kinase
YKL193c     SDS22    regulatory subunit for the mitotic function of type I protein phosphatase
YBR274w     CHK1     regulats inhibitory Cdk phosphorylation of PDS1
YMR213w     CEF1     required during G2/M transition
YMR078c     CTF18    required for accurate chromosome transmission in mitosis and maintenance of normal telomere length
YIL106w     MOB1     required for completion of mitosis and maintenance of ploidy
YOL145c     CTR9     required for G1 cyclin expression
YJR090c     GRR1     required for glucose repression and for glucose and cation transport
YJL080c     SCP160   required for maintenance of exact ploidy
YLR103c     CDC45    required for minichromosome maintenance and initiation of chromosomal DNA replication
YPR082c     DIB1     required for mitosis
YKL089w     MIF2     required for normal chromosome segregation and spindle integrity
YIL150c     DNA43    required for S-phase initiation or completion
YGR098c     ESP1     required for sister chromatid separation
YJL074c     SMC3     required for structural maintenance of chromosomes
YDR488c     PAC11    required in the absence of CIN8P
YDL225w     SHS1     septin
YHR107c     CDC12    septin
YJR076c     CDC11    septin
YGL190c     CDC55    ser/thr phosphatase 2A regulatory subunit B
YER133w     GLC7     ser/thr phosphoprotein phosphatase 1, catalytic chain
YBL105c     PKC1     ser/thr protein kinase
YDR507c     GIN4     ser/thr protein kinase
YGL158w     RCK1     ser/thr protein kinase
YGR188c     BUB1     ser/thr protein kinase
YJL106w     IME2     ser/thr protein kinase
YJL141c     YAK1     ser/thr protein kinase
YMR104c     YPK2     ser/thr protein kinase
YOR231w     MKK1     ser/thr protein kinase
YPL209c     IPL1     ser/thr protein kinase
YPR161c     SGV1     ser/thr protein kinase
YHR030c     SLT2     ser/thr protein kinase of MAP kinase family
YJL095w     BCK1     ser/thr protein kinase of the MEKK family
YGR092w     DBF2     ser/thr protein kinase related to DBF20P
YHR102w     KIC1     ser/thr protein kinase that interacts with CDC31P
YKL101w     HSL1     ser/thr protein kinase, coupling septin ring assembly to cell cycle progression
YDL047w     SIT4     ser/thr protein phosphatase
YAL016w     TPD3     ser/thr protein phosphatase 2A, regulatory chain A
YKL048c     ELM1     ser/thr-specific protein kinase
YNL307c     MCK1     ser/thr/tyr protein kinase
YPL153c     RAD53    ser/thr/tyr protein kinase
YJL187c     SWE1     ser/tyr dual-specifity protein kinase
YIL095w     PRK1     serine/threonine protein kinase involved in regulation of actin cytoskeleton organization
YHR205w     SCH9     serine/threonine protein kinase involved in stress response and nutrient-sensing signaling pathway
YDL028c     MPS1     serine/threonine/tyrosine protein kinase
YLL003w     SFI1     similarity to  Xenopus laevis XCAP-C
YNL246w              similarity to D.melanogaster SET protein
YAR003w     FUN16    similarity to human RB protein binding protein
YKL179c              similarity to NUF1P
YMR262w              similarity to S.pombe scn1 protein
YLR356w              similarity to SCM4 protein
YLR179c              similarity to TFS1P
YFR040w     SAP155   SIT4P-associated protein
YGL229c     SAP4     SIT4P-associated protein
YKR028w     SAP190   SIT4P-associated protein
YJL098w     SAP185   SIT4P-associating protein
YPL178w     CBC2     small subunit of the nuclear cap-binding protein complex CBC
YIL031w     ULP2     SMT3P-specific protease, degrades conjugated ubiquitin-like protein SMT3P
YGL086w     MAD1     spindle assembly checkpoint protein
YJR053w     BFA1     spindle assembly checkpoint protein
YMR198w     CIK1     spindle pole body associated protein
YDR356w     NUF1     spindle pole body component
YHR172w     SPC97    spindle pole body component
YKL042w     SPC42    spindle pole body component
YNL126w     SPC98    spindle pole body component
YOR257w     CDC31    spindle pole body component, centrin
YOL069w     NUF2     spindle pole body protein
YJL013c     MAD3     spindle-assembly checkpoint protein
YJL030w     MAD2     spindle-assembly checkpoint protein
YER066w              strong similarity to cell division control protein CDC4P
YLR117c     CLF1     strong similarity to Drosophila putative cell cycle control protein crn
YBR238c              strong similarity to general chromatin factor SPT16P
YGL056c     SDS23    strong similarity to pombe SDS23
YLR215c     CDC123   strong similarity to rat cell cycle progression related D123 protein
YKL161c     (MLP1)   strong similarity to ser/thr-specific protein kinase SLT2P
YOL080c     REX4     strong similarity to X.laevis XPMC2 protein and YGR276c
YGL003c     CDH1     substrate-specific activator of APC-dependent proteolysis
YBL084c     CDC27    subunit of anaphase-promoting complex (cyclosome)
YFR036w     CDC26    subunit of anaphase-promoting complex (cyclosome)
YHR166c     CDC23    subunit of anaphase-promoting complex (cyclosome)
YKL022c     CDC16    subunit of anaphase-promoting complex (cyclosome)
YNL172w     APC1     subunit of anaphase-promoting complex (cyclosome)
YNR010w     CSE2     subunit of RNA polymerase II mediator complex
YDL008w     APC11    subunit of the anaphase promoting complex
YDR118w     APC4     subunit of the anaphase promoting complex
YLR102c     APC9     subunit of the Anaphase Promoting Complex
YCR052w     RSC6     subunit of the RSC complex
YFR037c     RSC8     subunit of the RSC complex
YIL126w     STH1     subunit of the RSC complex
YLR321c     SFH1     subunit of the RSC complex
YOR213c     SAS5     subunit of the RSC complex
YJR091c     JSN1     suppresses the high-temperature lethality of TUB2-150
YDR099w     BMH2     suppressor of clathrin deficiency
YOR057w     SGT1     suppressor of G2 allele of SKP1
YER167w     BCK2     suppressor of mutations in protein kinase C pathway components
YDR285w     ZIP1     synaptonemal complex protein
YDR416w     SYF1     synthetic lethal with CDC40
YBL088c     TEL1     telomere length control protein
YPL129w     ANC1     TFIIF subunit (transcription initiation factor), 30 kD
YPR025c     CCL1     TFIIH subunit (transcription initiation factor), cyclin C component
YLR043c     TRX1     thioredoxin I
YGR209c     TRX2     thioredoxin II
YOL115w     TRF4     topoisomerase I-related protein
YDL165w     CDC36    transcription factor
YER111c     SWI4     transcription factor
YLR182w     SWI6     transcription factor
YGL181w     GTS1     transcription factor of the GCS1P/GLO3P/SPS18P family
YMR043w     MCM1     transcription factor of the MADS box family
YHR206w     SKN7     transcription factor with similarity to HSF1P
YDL056w     MBP1     transcription factor, subunit of the MBF factor
YOR028c     CIN5     transcriptional activator
YNL012w     SPO1     transcriptional regulator involved in sporulation
YBR079c     RPG1     translation initiation factor eIF3 (p110 subunit)
YOR361c     PRT1     translation initiation factor eIF3 subunit
YHR165c     PRP8     U5 snRNP protein, pre-mRNA splicing factor
YMR276w     DSK2     ubiquitin-like protein
YBR243c     ALG7     UDP-N-acetylglucosamine-1-phosphate transferase
YML115c     VAN1     vanadate resistance protein
YPL126w     NAN1     weak similarity to fruit fly TFIID subunit p85
YBR107c     IML3     weak similarity to N.crassa chitin synthase
YDR130c     FIN1     weak similarity to sea urchin myosin heavy chain
YER122c     GLO3     zinc finger protein
YLR403w     SFP1     zinc finger protein
YGR044c     RME1     zinc-finger transcription factor

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