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Saccharomyces cerevisiae - Functional Catalogue |
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protein targeting, sorting and translocation (140 ORFs)
YPL259c APM1 AP-1 complex subunit, mu1 subunit, 54 KD YOL062c APM4 AP-2 complex subunit, mu2 subunit, 55 KD YKL073w LHS1 chaperone of the ER lumen YOR020c HSP10 chaperonin, mitochondrial YKL002w DID4 class E vacuolar-protein sorting and endocytosis factor YKR035w-a DID2 class E vacuolar-protein sorting and endocytosis factor YLR025w SNF7 class E Vps protein YGL206c CHC1 clathrin heavy chain YOR297c TIM18 component of the inner mitochondrial membrane translocation complex YLR417w VPS36 defective in vacuolar protein sorting YJR135w-a TIM8 delivers Proteins across the intermembrane space of mitochondria to the TIM22 complex YDL212w SHR3 endoplasmatic reticulum membrane protein YKL041w VPS24 endosomal Vps protein complex subunit YIL076w SEC28 epsilon-COP coatomer subunit YBL040c ERD2 ER lumen protein-retaining receptor YDR086c SSS1 ER protein-translocase complex subunit YBR171w SEC66 ER protein-translocation complex subunit YER019c-a SBH2 ER protein-translocation complex subunit YLR292c SEC72 ER protein-translocation complex subunit YLR378c SEC61 ER protein-translocation complex subunit YOR254c SEC63 ER protein-translocation complex subunit YPL094c SEC62 ER protein-translocation complex subunit YEL020w-a TIM9 essential subunit of the TIM22-complex for mitochondrial protein import YMR203w TOM40 forms the hydrophilic channel of the mitochondrial import pore for preproteins YPL037c EGD1 GAL4 DNA-binding enhancer protein YJR074w MOG1 GSP1-interacting protein YOR089c VPS21 GTP-binding protein YKR014c YPT52 GTP-binding protein of the rab family YNL093w YPT53 GTP-binding protein of the RAB family (RAS superfamily) YOR270c VPH1 H+-ATPase V0 domain 95K subunit, vacuolar YAL005c SSA1 heat shock protein of HSP70 family, cytosolic YMR214w SCJ1 homolog of E. coli DnaJ, functions in the endoplasmic reticulum by interaction with KAR2P YGL238w CSE1 importin-beta-like protein YGR028w MSP1 intra-mitochondrial sorting protein YCR075c ERS1 intracellular protein transport protein YBR283c SSH1 involved in co-translational pathway of protein transport YOR069w VPS5 involved in Golgi retention and vacuolar sorting YLL040c VPS13 involved in regulating membrane traffic YER101c AST2 involved in targeting of plasma membrane [H+]ATPase YER087c-b SBH1 involved in translocation into the ER YHR012w VPS29 involved in vacuolar protein sorting YLR309c IMH1 involved in vesicular transport YNL189w SRP1 karyopherin-alpha or importin YLR347c KAP95 karyopherin-beta YOL122c SMF1 manganese transporter YKR001c VPS1 member of the dynamin family of GTPases YGL016w KAP122 Member of the karyopherin-beta family, nuclear import YGL241w KAP114 Member of the karyopherin-beta family, nuclear import YDR468c TLG1 member of the syntaxin family of t-SNAREs YOL018c TLG2 member of the syntaxin family of t-SNAREs YMR292w GOT1 Membrane protein required for ER to Golgi transport YNL064c YDJ1 mitochondrial and ER import protein YML062c MFT1 mitochondrial fusion target protein YIL022w TIM44 mitochondrial inner membrane import receptor subunit YJL143w TIM17 mitochondrial inner membrane import translocase subunit YNR017w MAS6 mitochondrial inner membrane import translocase subunit YMR035w IMP2 mitochondrial inner membrane protease subunit YNL121c TOM70 mitochondrial outer membrane specialized import receptor YNL131w TOM22 mitochondrial outer membrane import receptor complex subunit YGR082w TOM20 mitochondrial outer membrane import receptor subunit, 20 kD YMR060c TOM37 mitochondrial outer membrane import receptor subunit, 37 kD YOR045w TOM6 mitochondrial outer membrane import receptor subunit, 6 kD YNL070w TOM7 mitochondrial outer membrane import receptor subunit, 7 kD YJL034w KAR2 nuclear fusion protein YMR091c NPL6 nuclear protein localization factor YBR170c NPL4 nuclear protein localization factor and ER translocation component YPL125w KAP120 nuclear transport factor, member of karyopherin-beta family YDR432w NPL3 nucleolar protein YAR002c-a ERP1 p24 protein involved in membrane trafficking YGR239c PEX21 peroxin, essential for peroxisomal targeting by the PTS2 pathway YHR160c PEX18 peroxin, essential for peroxisomal targeting by the PTS2 pathway YDR142c PEX7 peroxisomal import protein - peroxin YGL153w PEX14 peroxisomal protein involved in protein import - peroxin YLR191w PEX13 peroxisomal protein involved in protein import - peroxin YDR244w PEX5 peroxisomal targeting signal receptor YPR047w MSF1 phenylalanine--tRNA ligase alpha chain, mitochondrial YFR019w FAB1 phosphatidylinositol 3-phosphate 5-kinase YBL069w AST1 PMA1 protein targeting protein YHR050w SMF2 probable manganese transporter YLR168c (MSF1) probably involved in intramitochondrial protein sorting YMR150c IMP1 protease, mitochondrial YLR360w VPS38 protein involved in vacuolar sorting YKL176c LST4 protein required for regulated transport of nitrogen-regulated permeases from the Golgi to the plasma membrane YJL154c VPS35 protein-sorting protein, vacuolar YER110c KAP123 RAN-binding protein YCL001w RER1 required for correct localization of SEC12P YEL059c-a SOM1 required for mitochondrial IMP1 peptidase function YDR414c ERD1 required for retention of luminal ER proteins YDR005c MAF1 required for sorting of MOD5P YMR004w MVP1 required for vacuolar protein sorting YEL013w VAC8 required for vacuole inheritance and protein targeting from the cytoplasm to vacuole YBR162w-a YSY6 secretory pathway protein YDR498c SEC20 secretory pathway protein YBR097w VPS15 ser/thr protein kinase YPL210c SRP72 signal recognition particle protein YPL243w SRP68 signal recognition particle protein YDR292c SRP101 signal recognition particle receptor, alpha chain YKL154w SRP102 signal recognition particle receptor, beta chain YDL092w SRP14 signal recognition particle subunit YKL122c SRP21 signal recognition particle subunit YML105c SEC65 signal recognition particle subunit YOR285w similarity to D.melanogaster heat shock protein 67B2 YOR286w similarity to D.melanogaster heat shock protein 67B2 YOR016c ERP4 similarity to human COP-coated vesicle membrane protein YHR110w ERP5 similarity to human gp25L2 protein YDR117c similarity to mouse ligatin, a trafficking receptor for phosphoglycoproteins YMR018w similarity to tetratricopeptide-repeat protein PAS10 YKL196c YKT6 SNARE protein for Endoplasmic Reticulum-Golgi transport YHL031c GOS1 SNARE protein of Golgi compartment YGL002w ERP6 strong similarity to human gp25L2 protein YDR185c strong similarity to MSF1P YJL222w VTH2 strong similarity to PEP1P YCR099c strong similarity to PEP1P, VTH1P and VTH22p YCR100c strong similarity to PEP1P, VTH1P and VTH22p YCR101c strong similarity to PEP1P, VTH1P and VTH22p YIL173w VTH1 strong similarity to VTH2P and PEP1P, potential membrane glycoprotein YBR091c MRS5 subunit of the TIM22-complex YDL217c TIM22 subunit of the TIM22-complex YHR005c-a MRS11 subunit of the TIM22-complex YOR329c SCD5 suppressor of clathrin deficiency YOR327c SNC2 synaptobrevin (v-SNARE) homolog present on post-Golgi vesicles YOR036w PEP12 syntaxin (T-SNARE), vacuolar YJL054w TIM54 translocase for the insertion of proteins into the mitochondrial inner membrane YMR197c VTI1 v-SNARE: involved in Golgi retrograde protein traffic YMR231w PEP5 vacuolar biogenesis protein YLR148w PEP3 vacuolar membrane protein YNL054w VAC7 vacuolar protein YGL095c VPS45 vacuolar protein sorting-associated protein YNR006w VPS27 vacuolar protein sorting-associated protein YOR132w VPS17 vacuolar protein sorting-associated protein YBL017c PEP1 vacuolar protein sorting/targeting protein YJL053w PEP8 vacuolar protein sorting/targeting protein YDR323c PEP7 vacuolar segregation protein YDR495c VPS3 vacuolar sorting protein YLR396c VPS33 vacuolar sorting protein YML097c VPS9 vacuolar sorting protein YPL045w VPS16 vacuolar sorting protein YPR173c VPS4 vacuolar sorting protein YAL002w VPS8 vacuolar sorting protein, 134 kD YOR357c GRD19 weak similarity to human sorting nexin 1
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