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Saccharomyces cerevisiae - Functional Catalogue |
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CELL RESCUE, DEFENSE, CELL DEATH AND AGEING (363 ORFs)
YJL001w PRE3 20S proteasome subunit (beta1) YER012w PRE1 20S proteasome subunit C11(beta4) YGR253c PUP2 20S proteasome subunit(alpha5) YFR052w RPN12 26S proteasome regulatory subunit YKL145w RPT1 26S proteasome regulatory subunit YER142c MAG1 3-methyladenine DNA glycosylase YML060w OGG1 8-oxoguanine DNA glycosylase YOL158c ENB1 a gene of the major facilitator superfamily encodes a transporter for enterobactin YDR077w SED1 abundant cell surface glycoprotein YPR026w ATH1 acid trehalase, vacuolar YOL052c SPE2 adenosylmethionine decarboxylase precursor YBR145w ADH5 alcohol dehydrogenase V YHR104w GRE3 aldose reductase YLR109w AHP1 Alkyl hydroperoxide reductase YDR074w TPS2 alpha,alpha-trehalose-phosphate synthase, 102 KD subunit YBR126c TPS1 alpha,alpha-trehalose-phosphate synthase, 56 KD subunit YML116w ATR1 aminotriazole and 4-nitroquinoline resistance protein YNL259c ATX1 antioxidant protein and metal homeostasis factor YPR189w SKI3 antiviral protein YLR398c SKI2 antiviral protein and putative helicase YGL213c SKI8 antiviral protein of the beta-transducin (WD-40) repeat family YKL114c APN1 AP endonuclease YBL019w APN2 AP endonuclease, exonuclease III homolog YPR200c ARR2 arsenate reductase YJL092w HPR5 ATP-dependent DNA helicase YMR015c ERG5 C-22 sterol desaturase YNL027w CRZ1 calcineurin responsive zinc-finger YBR131w CCZ1 Calcium Caffeine Zinc sensitivity YIL033c BCY1 cAMP dependent protein kinase, regulatory subunit YDR477w SNF1 carbon catabolite derepressing ser/thr protein kinase YHR135c YCK1 casein kinase I isoform YNL154c YCK2 casein kinase I isoform YPL204w HRR25 casein kinase I, ser/thr/tyr protein kinase YDR256c CTA1 catalase A, peroxisomal YGR088w CTT1 catalase T, cytosolic YOL105c WSC3 cell wall integrity and stress response component 3 YHL028w WSC4 Cell wall integrity and stress response component 4 YBR044c TCM62 chaperone required for assembly of mitochondrial succinate dehydrogenase YDR251w PAM1 coiled-coil protein multicopy suppressor of loss of PP2A YOR010c TIR2 cold shock induced protein YER011w TIR1 cold-shock induced protein of the TIR1P,TIP1P family YMR106c YKU80 component of DNA end-joining repair pathway YPR056w TFB4 component of RNA polymerase transcription initiation TFIIH factor YPL022w RAD1 component of the nucleotide excision repairosome YJR069c HAM1 controls 6-N-hydroxylaminopurine sensitivity and mutagenesis YMR038c LYS7 copper chaperone for superoxide dismutase SOD1P YJR104c SOD1 copper-zinc superoxide dismutase YDL108w KIN28 cyclin-dependent ser/thr protein kinase YDR155c CPH1 cyclophilin (peptidylprolyl isomerase) YDR402c DIT2 cytochrome P450 56 YHR007c ERG11 cytochrome P450 lanosterol 14a-demethylase YEL039c CYC7 cytochrome-c isoform 2 YKR066c CCP1 cytochrome-c peroxidase precursor YML086c ALO1 D-arabinono-1,4-lactone oxidase YOR386w PHR1 deoxyribodipyrimidine photo-lyase YOR163w DDP1 diadenosine hexaphosphate (Ap6A) hydrolase YKR053c YSR3 dihydrosphingosine-1-phosphate phosphatase YFL053w DAK2 dihydroxyacetone kinase YML070w DAK1 dihydroxyacetone kinase, induced in high salt YBR180w DTR1 dityrosine transporter YOL130w ALR1 divalent cation transporter YFL050c ALR2 divalent cation transprter YER062c HOR2 DL-glycerol phosphatase YOR368w RAD17 DNA damage checkpoint control protein YPL194w DDC1 DNA damage checkpoint protein YGL021w ALK1 DNA damage-responsive protein YDR096w GIS1 DNA damage-responsive repressor of PHR1 YER176w ECM32 DNA dependent ATPase/DNA helicase B YIL143c SSL2 DNA helicase YLR032w RAD5 DNA helicase YMR190c SGS1 DNA helicase YML061c PIF1 DNA helicase involved in mitochondrial DNA repair and telomere length YER171w RAD3 DNA helicase/ATPase YDL164c CDC9 DNA ligase YOR005c DNL4 DNA ligase IV YGL090w LIF1 DNA ligase IV interacting factor YIL139c REV7 DNA polymerase zeta subunit YMR224c MRE11 DNA repair and meiotic recombination protein YAL015c NTG1 DNA repair protein YCR066w RAD18 DNA repair protein YDR004w RAD57 DNA repair protein YDR076w RAD55 DNA repair protein YDR369c XRS2 DNA repair protein YDR419w RAD30 DNA repair protein YEL019c MMS21 DNA repair protein YER095w RAD51 DNA repair protein YML095c RAD10 DNA repair protein YMR137c PSO2 DNA repair protein YNL250w RAD50 DNA repair protein YOR346w REV1 DNA repair protein YDR263c DIN7 DNA-damage inducible protein YGL163c RAD54 DNA-dependent ATPase of the SNF2P family YJR006w HYS2 DNA-directed DNA polymerase delta, 55 KD subunit YDL102w CDC2 DNA-directed DNA polymerase delta, catalytic 125 KD subunit YFR023w PES4 DNA-directed DNA polymerase epsilon suppressor YNL262w POL2 DNA-directed DNA polymerase epsilon, catalytic subunit A YPL167c REV3 DNA-directed DNA polymerase zeta subunit YDR404c RPB7 DNA-directed RNA polymerase II, 19 KD subunit YJL140w RPB4 DNA-directed RNA polymerase II, 32 kDa subunit YPR198w SGE1 drug resistance protein YKL210w UBA1 E1-like (ubiquitin-activating) enzyme YBR082c UBC4 E2 ubiquitin-conjugating enzyme YDR059c UBC5 E2 ubiquitin-conjugating enzyme YGL058w RAD6 E2 ubiquitin-conjugating enzyme YMR022w QRI8 E2 ubiquitin-conjugation enzyme YKR056w RNC1 endo-exonuclease YOL043c NTG2 endonuclease III-like glycosylase 2 YBR067c TIP1 esterase YHR032w ERC1 ethionine resistance protein YER162c RAD4 excision repair protein YHL040c ARN1 ferrichrome-type siderophore transporter YDR519w FKB2 FK506/rapamycin-binding protein of the ER YGR234w YHB1 flavohemoglobin YBR008c FLR1 fluconazole resistance protein YLR288c MEC3 G2-specific checkpoint protein YNL241c ZWF1 glucose-6-phosphate dehydrogenase YJL101c GSH1 glutamate--cysteine ligase YCL035c GRX1 glutaredoxin YDR513w TTR1 glutaredoxin YIR037w HYR1 glutathione peroxidase YKL026c GPX1 glutathione peroxidase YBR244w GPX2 glutathione peroxidases YPL091w GLR1 glutathione reductase (NADPH) YDR135c YCF1 glutathione S-conjugate transporter, vacuolar YIR038c GTT1 glutathione S-transferase YLL060c GTT2 glutathione S-transferase YLL043w FPS1 glycerol channel protein YDL022w GPD1 glycerol-3-phosphate dehydrogenase (NAD+), cytoplasmic YNL098c RAS2 GTP-binding protein YOR101w RAS1 GTP-binding protein YEL027w CUP5 H+-ATPase V0 domain 17 KD subunit, vacuolar YBR072w HSP26 heat shock protein YCR021c HSP30 heat shock protein YFL014w HSP12 heat shock protein YLL026w HSP104 heat shock protein YMR173w DDR48 heat shock protein YMR186w HSC82 heat shock protein YPL240c HSP82 heat shock protein YFL016c MDJ1 heat shock protein - chaperone YNL328c MDJ2 heat shock protein - chaperone YLR259c HSP60 heat shock protein - chaperone, mitochondrial YOL052c-a DDR2 heat shock protein DDRA2 YDR258c HSP78 heat shock protein of clpb family of ATP-dependent proteases, mitochondrial YEL030w ECM10 heat shock protein of HSP70 family YPL106c SSE1 heat shock protein of HSP70 family YAL005c SSA1 heat shock protein of HSP70 family, cytosolic YBL075c SSA3 heat shock protein of HSP70 family, cytosolic YER103w SSA4 heat shock protein of HSP70 family, cytosolic YLL024c SSA2 heat shock protein of HSP70 family, cytosolic YBR169c SSE2 heat shock protein of the HSP70 family YGL073w HSF1 heat shock transcription factor YER057c HIG1 Heat-shock induceable Inhibiter of cell Growth YER125w RSP5 hect domain E3 ubiquitin-protein ligase YMR284w YKU70 high-affinity DNA-binding protein YJR147w HMS2 High-copy MEP2 Suppressor YML058w-a HUG1 hydroxyurea and UV and gamma radiation induced YMR251w-a HOR7 hyperosmolarity-responsive protein YPL223c GRE1 induced by osmotic stress YER143w DDI1 induced in response to DNA alkylation damage YPL164c MLH3 insertion and deletion mismatch repair protein YGR213c RTA1 involved in 7-aminocholesterol resistance YIL123w SIM1 involved in cell cycle regulation and aging YOL025w LAG2 involved in determining longevity YMR273c ZDS1 involved in negative regulation of cell polarity YIL128w MET18 involved in NER repair and RNA polymerase II transcription YGR197c SNG1 involved in nitroguanidine resistance YJL116c NCA3 involved in regulation of synthesis of ATP6P and Atp8p YKL110c KTI12 involved in resistance to K.lactis killer toxin YKR042w UTH1 involved in the aging process YER118c SHO1 involved in the HOG1 high-osmolarity signal transduction pathway YDR386w MUS81 involved in the repair of UV and methylation induced DNA damage YDR293c SSD1 involved in the tolerance to high concentration of Ca2+ YGR144w THI4 involved in thiamine biosynthesis and DNA repair YPR141c KAR3 kinesin-related protein YDL168w SFA1 long-chain alcohol dehydrogenase YHL003c LAG1 longevity-assurance protein YKL143w LTV1 low-temperature viability protein YGR100w MDR1 MAC1P interacting protein YCR073c SSK22 MAP kinase kinase kinase YNR031c SSK2 MAP kinase kinase kinase of the high osmolarity signal transduction pathway YNR055c HOL1 member of major facilitator superfamily multidrug-resistance protein subfamily 1 YNL239w LAP3 member of the GAL regulon YJL159w HSP150 member of the PIR1P/HSP150P/PIR3P family YKL163w PIR3 member of the PIR1P/Pir2p/PIR3P family YDR098c GRX3 member of the subfamily of yeast glutaredoxins (Grx3, GRX4, and Grx5) YER174c GRX4 member of the subfamily of yeast glutaredoxins (Grx3, GRX4, and Grx5) YPL059w GRX5 member of the subfamily of yeast glutaredoxins (Grx3, GRX4, and Grx5) YDR033w MRH1 membrane protein related to HSP30P YMR021c MAC1 metal binding activator YHR053c CUP1-1 metallothionein YHR055c CUP1-2 metallothionein YNL064c YDJ1 mitochondrial and ER import protein YLR369w SSQ1 mitochondrial heat shock protein 70 YJR045c SSC1 mitochondrial heat shock protein 70-related protein YMR035w IMP2 mitochondrial inner membrane protease subunit YCR083w TRX3 mitochondrial thioredoxin YGL178w MPT5 multicopy suppressor of POP2 YOR079c ATX2 multicopy suppressor of SOD-linked defects YDR011w SNQ2 multidrug resistance protein YKR095w MLP1 myosin-like protein related to USO1P YDR456w NHX1 NA+-H+ antiporter YHR042w NCP1 NADPH-cytochrome P450 reductase YGR159c NSR1 nuclear localization sequence binding protein YGL115w SNF4 nuclear regulatory protein YBR114w RAD16 nucleotide excision repair protein YJR052w RAD7 nucleotide excision repair protein YMR201c RAD14 nucleotide excision repair protein YEL037c RAD23 nucleotide excision repair protein (ubiquitin-like protein) YOR018w ROD1 O-dinitrobenzene,calcium and zinc resistance protein YDL200c MGT1 O6-methylguanine DNA repair methyltransferase YJR051w OSM1 osmotic growth protein YMR175w SIP18 osmotic stress protein YBR070c SAT2 osmotolerance protein YKL064w MNR2 overexpression overcomes manganese toxicity YGL087c MMS2 part of the error-free postreplication repair pathway YOR266w PNT1 pentamidine resistance factor YHR057c CYP2 peptidyl-prolyl cis-trans isomerase YDR538w PAD1 phenylacrylic acid decarboxylase YOR153w PDR5 pleiotropic drug resistance protein YBL005w PDR3 pleiotropic drug resistance regulatory protein YLL028w TPO1 polyamine transport protein YJR043c POL32 polymerase-associated gene, third (55 kDa) subunit of DNA polymerase delta YOR014w RTS1 potential regulatory subunit of protein phosphatase 2A YEL065w SIT1 probable multidrug resistance protein YMR174c PAI3 protease A (ysca) inhibitor IA3 YIR002c MPH1 protection of the genome from spontaneous and chemically induced damage YDL101c DUN1 protein kinase YHR079c IRE1 protein kinase YPL140c MKK2 protein kinase of the map kinase kinase (MEK) family YKL008c LAC1 protein required with LAG1P for ER-to-Golgi transport of GPI-anchored proteins YOL064c MET22 protein ser/thr phosphatase YDR436w PPZ2 protein ser/thr phosphatase of the PP-1 family YDL006w PTC1 protein serine/threonine phosphatase 2c YOR208w PTP2 protein-tyrosine-phosphatase YBR098w MMS4 putative transcriptional (co)activator for DNA damage YML032c RAD52 recombination and DNA repair protein YHR064c PDR13 regulator protein involved in pleiotropic drug resistance YOR008c SLG1 required for cell wall integrity and for stress response YJR090c GRR1 required for glucose repression and for glucose and cation transport YJR055w HIT1 required for growth at high temperature YBR073w RDH54 required for mitotic diploid-specific recombination and repair and meiosis YPL084w BRO1 required for normal response to nutrient limitation YKL164c PIR1 required for tolerance to heat shock YER042w MXR1 responsible for the reduction of methionine sulfoxide YGR180c RNR4 ribonucleotide reductase small subunit YIL066c RNR3 ribonucleotide reductase, repair inducible large subunit YPR005c HAL1 salt-induced protein YNL160w YGP1 secreted glycoprotein YGL190c CDC55 ser/thr phosphatase 2A regulatory subunit B YML016c PPZ1 ser/thr phosphatase required for normal osmoregulation YBL105c PKC1 ser/thr protein kinase YJL165c HAL5 ser/thr protein kinase YOR231w MKK1 ser/thr protein kinase YLR113w HOG1 ser/thr protein kinase of MAP kinase (MAPK) family YHR030c SLT2 ser/thr protein kinase of MAP kinase family YJL095w BCK1 ser/thr protein kinase of the MEKK family YPL153c RAD53 ser/thr/tyr protein kinase YCR008w SAT4 serine/threonine-specific protein kinase YHL047c TAF1 siderophore transporter for triacetylfusarinine C YDR227w SIR4 silencing regulatory and DNA-repair protein YLR442c SIR3 silencing regulatory and DNA-repair protein YDL042c SIR2 silencing regulatory protein and DNA-repair protein YLL003w SFI1 similarity to Xenopus laevis XCAP-C YIL120w QDR1 similarity to antibiotic resistance proteins YIL121w similarity to antibiotic resistance proteins YDR119w similarity to B.subtilis tetracyclin resistance YBR043c similarity to benomyl/methotrexate resistance protein YKL088w similarity to C.tropicalis hal3 protein, to C-term. of SIS2P and to hypothetical protein YOR054c YDL100c similarity to E.coli arsenical pump-driving ATPase YLL057c similarity to E.coli dioxygenase YDR061w similarity to E.coli modF and photorepair protein phrA YGR249w MGA1 similarity to heat shock transcription factors YAL019w FUN30 similarity to helicases of the SNF2/RAD54 family YLR035c MLH2 similarity to human mutL protein homolog, mouse PMS2, MLH1P and PMS1P YER076c similarity to killer toxin Khr1p YER187w similarity to killer toxin KHS precursor YBR293w similarity to multidrug resistance proteins YGR138c similarity to multidrug resistance proteins YHR048w similarity to multidrug resistance proteins YKR103w similarity to multidrug resistance proteins YKR104w similarity to multidrug resistance proteins YMR088c similarity to multidrug resistance proteins YPR156c similarity to multidrug resistance proteins YDL025c similarity to probable protein kinase NPR1 YNL065w BZR1 similarity to resistance proteins YOR273c similarity to resistance proteins YFR022w similarity to ROD1P YOR054c similarity to SIS2P protein and C.tropicalis hal3 protein YCR060w similarity to stress inducible protein STI1P YOR251c similarity to thiosulfate sulfurtransferases YOR009w TIR4 similarity to TIR1P and TIR2P YOR247w SRL1 similarity to vanadate sensitive suppressor SVS1P YLL015w BPT1 similarity to YCF1P, YOR1P, rat organic anion transporter YBR103w SIF2 SIR4P interacting protein YJL134w LCB3 sphingoid base-phosphate phosphatase YKL113c RAD27 ssDNA endonuclease and 5'-3'exonuclease YMR037c MSN2 stress responsive regulatory protein YOR027w STI1 stress-induced protein YMR279c strong similarity to aminotriazole resistance protein YOR378w strong similarity to aminotriazole resistance protein YBL009w strong similarity to DNA damage responsive ALK1P YCL069w strong similarity to drug resistance protein SGE1 YGR224w AZR1 strong similarity to drug resistance protein SGE1, YKR105c and YCL069W YKL033w-a strong similarity to holacid-halidohydrolase YBR054w YRO2 strong similarity to HSP30 heat shock protein Yro1p YIL153w RRD1 strong similarity to human phosphotyrosyl phosphatase activator YCR104w PAU3 strong similarity to members of the SRP1/TIP1P family YAR020c PAU7 strong similarity to members of the SRP1P/TIP1P family YEL049w PAU2 strong similarity to members of the SRP1P/TIP1P family YFL020c PAU5 strong similarity to members of the SRP1P/TIP1P family YHL046c strong similarity to members of the SRP1P/TIP1P family YIL011w TIR3 strong similarity to members of the SRP1P/TIP1P family YJL223c PAU1 strong similarity to members of the SRP1P/TIP1P family YOL161c strong similarity to members of the SRP1P/TIP1P family YLR461w PAU4 strong similarity to members of the TIR1P/TIP1P family YNR076w PAU6 strong similarity to members of the TIR1P/TIP1P family YFR038w strong similarity to mouse lymphocyte specific helicase YJL158c CIS3 strong similarity to PIR1P/HSP150P/PIR3P family YJL160c strong similarity to PIR1P/HSP150P/PIR3P family YLR046c strong similarity to RTA1P and Rtm1p protein YER185w strong similarity to Rtm1p YGR271w SLH1 strong similarity to S.pombe RNA helicase YKL161c (MLP1) strong similarity to ser/thr-specific protein kinase SLT2P YKR105c strong similarity to SGE1P and hypothetical protein YCL069w YJR015w strong similarity to SNG1P YNR070w strong similarity to SNQ2P YCL073c strong similarity to subtelomeric encoded proteins YKR106w strong similarity to subtelomeric encoded proteins YBL064c strong similarity to thiol-specific antioxidant enzyme YDR453c strong similarity to thiol-specific antioxidant proteins YNL066w SUN4 strong similarity to YIL123w, UTH1P, NCA3P and C. wickerhamii beta-glucosidase protein YGR258c RAD2 structure-specific nuclease of the nucleotide excision repairosome YGL254w FZF1 sulfite resistance protein YPL092w SSU1 sulfite sensitivity protein YHR008c SOD2 superoxide dismutase (Mn) precursor, mitochondrial YOR031w CRS5 suppressor of cup1 deletion, metallothionein-like protein YER167w BCK2 suppressor of mutations in protein kinase C pathway components YDL088c ASM4 suppressor of temperature-sensitive mutations in Pol3p YDR311w TFB1 TFIIH subunit (transcription initiation factor), 75 kD YPR025c CCL1 TFIIH subunit (transcription initiation factor), cyclin C component YLR005w SSL1 TFIIH subunit (transcription initiation factor), factor B YDR460w TFB3 TFIIH subunit (transcription/repair factor) YPL122c TFB2 TFIIH subunit (transcription/repair factor) YML028w TSA1 thiol-specific antioxidant YLR043c TRX1 thioredoxin I YGR209c TRX2 thioredoxin II YBL093c ROX3 transcription factor YGL013c PDR1 transcription factor YGL181w GTS1 transcription factor of the GCS1P/GLO3P/SPS18P family YMR043w MCM1 transcription factor of the MADS box family YHR206w SKN7 transcription factor with similarity to HSF1P YDR423c CAD1 transcriptional activator YKL062w MSN4 transcriptional activator YML007w YAP1 transcriptional activator involved in oxidative stress response YOL089c HAL9 transcriptional activator of ENA1 YIL147c SLN1 two-component signal transducer YLR006c SSK1 two-component signal transducer YJL128c PBS2 tyrosine protein kinase of the MAP kinase kinase family YLL039c UBI4 ubiquitin YPL163c SVS1 vanadate sensitive suppressor YGL128c weak similarity to dnaJ proteins YCR023c weak similarity to E.coli tetracycline resistance protein TCR1 YMR243c ZRC1 zinc- and cadmium resistance protein
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