casp references

DNA microarrays can be used to measure the expression patterns of thousands of genes in parallel, generating clues to gene function that can help to identify appropriate targets for therapeutic intervention. They can also be used to monitor changes in gene expression in response to drug treatments. Here, we discuss the different ways in which microarray analysis is likely to affect drug discovery.

Keywords: Agricultural, Alleles, Alternaria, Amino Acid, Amino Acid Chloromethyl Ketones, Amino Acid Sequence, Animal, Animals, Apoptosis, Asthma, Bacteria, Base Sequence, Binding Sites, Biotechnology, Blotting, Bone Density, Bone Matrix, Bone and Bones, CCR5, Camptothecin, Caspases, Cathepsins, Cell Surface, Central America, Chloroplast, Chondrocytes, Chromosome Mapping, Chromosomes, Cloning, Cluster Analysis, Collagen, Comparative Study, Coumarins, Crops, Crystallography, DNA, DNA Primers, Dipeptides, Disease, Disease Models, Drug Design, Drug Evaluation, Drug Industry, Enzyme Activation, Enzyme Inhibitors, Escherichia coli, Evolution, Exons, Expressed Sequence Tags, Female, Fetus, Fluorescent Dyes, Food Microbiology, Founder Effect, GTP-Binding Proteins, Gene Expression, Gene Frequency, Gene Library, Genes, Genetic, Genetic Predisposition to Disease, Genome, Geography, Growth Plate, Haplotypes, Hordeum, Human, Humans, Inclusion Bodies, Injections, Intraperitoneal, Introns, Isatin, Knockout, Male, Membrane Proteins, Messenger, Mice, Models, Molecular, Molecular Sequence Data, Molecular Structure, Mutation, Mycotoxins, Neutrophils, Non-U.S. Gov't, Northern, Oligonucleotide Array Sequence Analysis, Osteoarthritis, Osteochondrodysplasias, Osteoclasts, Osteopetrosis, Pair 15, Phaseolus, Polymorphism, Preclinical, Pregnancy, Promoter Regions (Genetics), Protein Precursors, Proteomics, RNA, Receptors, Recombinant Fusion Proteins, Recombinant Proteins, Research Support, Restriction Fragment Length, Ribosomal Proteins, Sequence Alignment, Sequence Analysis, Sequence Homology, South America, Species Specificity, Splenomegaly, Sulfonamides, Synteny, Tissue Distribution, Transcription, Trichothecenes, X-Ray, 9915501

Keywords: biosvm

Keywords: biosvm

Depending on whether similar structures are found in the PDB library, the protein structure prediction can be categorized into template-based modeling and free modeling. Although threading is an efficient tool to detect the structural analogs, the advancements in methodology development have come to a steady state. Encouraging progress is observed in structure refinement which aims at drawing template structures closer to the native; this has been mainly driven by the use of multiple structure templates and the development of hybrid knowledge-based and physics-based force fields. For free modeling, exciting examples have been witnessed in folding small proteins to atomic resolutions. However, predicting structures for proteins larger than 150 residues still remains a challenge, with bottlenecks from both force field and conformational search.

Keywords: casp8, modeling, zhang